Ricardo Alexandre Gomes Leitão

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PhD Student


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Information about journal articles, updated at 15-05-2022, from platform CIÊNCIAVITAE.

Impact of Traumatic Brain Injury on glia cells properties: Role of Neuropeptide Y

Leitão, Ricardo Alexandre; Alves, José Luis; Ana Luisa Bernardo; Carlos A Fontes-Ribeiro; Ana Paula Silva, 2022. submitted

The effect of parthenolide on methamphetamine-induced blood-brain barrier and astrocyte alterations

Ricardo Alexandre Leitão; Carlos A Fontes-Ribeiro; Ana Paula Silva, European Journal of Clinical Investigation. 2021. under revision European Journal of Clinical Investigation

A multi-staged neuropeptide response to traumatic brain injury

Alves, José Luís; Mendes, João; Leitão, Ricardo; Silva, Ana Paula; Pinto, Anabela Mota, European Journal of Trauma and Emergency Surgery. 2020. http://dx.doi.org/10.1007/s00068-020-01431-z . 10.1007/s00068-020-01431-z . published European Journal of Trauma and Emergency Surgery

Protective effect of neuropeptide Y2 receptor activation against methamphetamine-induced brain endothelial cell alterations

Ventura, Fabiana; Muga, Mariana; Coelho-Santos, Vanessa; Fontes-Ribeiro, Carlos A.; Leitão, Ricardo A.; Silva, Ana Paula, Toxicology Letters. 53 - 59. 334. 2020. http://dx.doi.org/10.1016/j.toxlet.2020.09.013 . 10.1016/j.toxlet.2020.09.013 . Toxicology Letters

Effect of chronic methylphenidate treatment on hippocampal neurovascular unit and memory performance in late adolescent rats

Coelho-Santos, Vanessa; Cardoso, Filipa L.; Magalhães, Ana; Ferreira-Teixeira, Margarida; Leitão, Ricardo A.; Gomes, Célia; Rito, Manuel; et al, European Neuropsychopharmacology. 195 - 210. 2. 29. 2019. http://dx.doi.org/10.1016/j.euroneuro.2018.12.007 . 10.1016/j.euroneuro.2018.12.007 . published European Neuropsychopharmacology

Effect of Hypoproteic and High-Fat Diets on Hippocampal Blood-Brain Barrier Permeability and Oxidative Stress

de Aquino, Cristhyane C.; Leitão, Ricardo Alexandre; Oliveira Alves, Luís A; Coelho-Santos, V.; Guerrant, Richard L.; Fontes-Ribeiro, Carlos A.; Malva, João O.; Silva, Ana P.; Oriá, Reinaldo B., Frontiers in Nutrition. 131. 5. 2019. https://www.frontiersin.org/article/10.3389/fnut.2018.00131 . 10.3389/fnut.2018.00131 . published Frontiers in Nutrition

Impact of developmental exposure to methylphenidate on rat brain’s immune privilege and behavior: Control versus ADHD model

Coelho-Santos, Vanessa; Cardoso, Filipa L.; Leitão, Ricardo A.; Fontes-Ribeiro, Carlos A.; Silva, Ana Paula, Brain, Behavior, and Immunity. 169 - 182. 68. 2018. http://dx.doi.org/10.1016/j.bbi.2017.10.016 . 10.1016/j.bbi.2017.10.016 . published Brain, Behavior, and Immunity

Testing the excitation/inhibition imbalance hypothesis in a mouse model of the autism spectrum disorder: in vivo neurospectroscopy and molecular evidence for regional phenotypes

Gonçalves, Joana; Violante, Inês R.; Sereno, José; Leitão, Ricardo A.; Cai, Ying; Abrunhosa, Antero; Silva, Ana Paula; Silva, Alcino J.; Castelo-Branco, Miguel, Molecular Autism. 1. 8. 2017. http://dx.doi.org/10.1186/s13229-017-0166-4 . 10.1186/s13229-017-0166-4 . published Molecular Autism

Extended-access methamphetamine self-administration elicits neuroinflammatory response along with blood-brain barrier breakdown

Gonçalves, Joana; Leitão, Ricardo A.; Higuera-Matas, Alejandro; Assis, María Amparo; Coria, Santiago M.; Fontes-Ribeiro, Carlos; Ambrosio, Emilio; Silva, Ana Paula, Brain, Behavior, and Immunity. 306 - 317. 62. 2017. http://dx.doi.org/10.1016/j.bbi.2017.02.017 . 10.1016/j.bbi.2017.02.017 . published Brain, Behavior, and Immunity

Aquaporin-4 as a New Target against Methamphetamine-Induced Brain Alterations: Focus on the Neurogliovascular Unit and Motivational Behavior

Leitão, Ricardo Alexandre; Sereno, José; Castelhano, João Miguel; Gonçalves, Sónia Isabel; Coelho-Santos, Vanessa; Fontes-Ribeiro, Carlos; Castelo-Branco, Miguel; Silva, Ana Paula, Molecular Neurobiology. 2056 - 2069. 3. 55. 2017. http://dx.doi.org/10.1007/s12035-017-0439-0 . 10.1007/s12035-017-0439-0 . published Molecular Neurobiology

Erratum: The TNF-a/NF-¿B signaling pathway has a key role in methamphetamine'induced blood'brain barrier dysfunction (Journal of Cerebral Blood Flow and Metabolism (2015) 35 (1260-1271))

Coelho-Santos, V.; Leitão, R.A.; Cardoso, F.L.; Palmela, I.; Rito, M.; Barbosa, M.; Brito, M.A.; Fontes-Ribeiro, C.A.; Silva, A.P., Journal of Cerebral Blood Flow and Metabolism. 2. 36. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84961296009&partnerID=MN8TOARS . 10.1177/0271678X15619790 . Journal of Cerebral Blood Flow and Metabolism

Methylphenidate-triggered ROS generation promotes caveolae-mediated transcytosis via Rac1 signaling and c-Src-dependent caveolin-1 phosphorylation in human brain endothelial cells

Coelho-Santos, Vanessa; Socodato, Renato; Portugal, Camila; Leitão, Ricardo A; Rito, Manuel; Barbosa, Marcos; Couraud, Pierre-Olivier; et al, Cellular and Molecular Life Sciences. 4701 - 4716. 24. 73. 2016. 10.1007/s00018-016-2301-3 . published Cellular and Molecular Life Sciences

The TNF-a/Nf-kB Signaling Pathway has a Key Role in Methamphetamine–Induced Blood–Brain Barrier Dysfunction

Coelho-Santos, Vanessa; Leitão, Ricardo A; Cardoso, Filipa L; Palmela, Inês; Rito, Manuel; Barbosa, Marcos; Brito, Maria A; Fontes-Ribeiro, Carlos A; Silva, Ana P, Journal of Cerebral Blood Flow & Metabolism. 1260 - 1271. 8. 35. 2015. http://dx.doi.org/10.1038/jcbfm.2015.59 . 10.1038/jcbfm.2015.59 . Journal of Cerebral Blood Flow & Metabolism

Psychostimulants and brain edema

Leitão, Ricardo Alexandre; Silva, Ana Paula, Research & Networks in Health. 1. 1. 2015. https://journals.ipleiria.pt/index.php/rnhealth/article/view/60 . published Research & Networks in Health

All projects

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Information of exclusive responsibility of the researcher 15-05-2022 , from platform CIÊNCIAVITAE.

2022/01/01 - 2023/07/31

Neutrophils infiltration through blood-brain barrier in traumatic brain injury: Role of CXCL8


Principal investigator

CNC.IBILI; Universidade de Coimbra Faculdade de Medicina

Funders: Fundação para a Ciência e a Tecnologia

2021/09 - 2023/08

Cerebrovascular hypothesis of stress-induced behavioral alterations



Funders: Fundação Bial

2020/01 - 2023/12

Strategic Project Center for Innovative Biomedicine and Biotechnology



Funders: Fundação para a Ciência e a Tecnologia; European Regional Development Fund

2018/01/03 - 2021/12/31

BrainHealth 2020 - Detecção Precoce, Neuro-modulação e Terapias Avançadas para Neuropatologias


Post-doc Fellow


2017/02/01 - 2018/02/28

Tackling CANcer STEM CELls: a challenge and an opportunity to advance in anti-cancer therapy


Research Fellow


Funders: Fundação para a Ciência e a Tecnologia

2013/06/01 - 2015/09/30

O metilfenidato e as alterações na barreira hemato-encefálica numa situação fisiológica e na perturbação de hiperatividade com défice de atenção (Methylphenidate and changes in the blood-brain barrier in a physiological situation and in attention deficit hyperactivity disorder)


Universidade de Coimbra; Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2013/06 - 2015/09

Methylphenidate and blood-brain barrier changes in health and attention deficit hyperactivity disorder

Provided by PTCRIS: 124592


Funders: Fundação para a Ciência e a Tecnologia, I.P.

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