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Information about journal articles, updated at 24-09-2023, from platform CIÊNCIAVITAE.

Extracellular vesicles improve GABAergic transmission in Huntington's disease iPSC-derived neurons

Margarida Beatriz; Rodrigues, Ricardo J.; Rita Vilaça; Conceição Egas; Paulo S. Pinheiro; George Q. Daley; Thorsten M. Schlaeger; et al, Theranostics. 3707 - 3724. 11. 13. 2023. . 10.7150/thno.81981 . published Theranostics

Increased ATP Release and Higher Impact of Adenosine A2A Receptors on Corticostriatal Plasticity in a Rat Model of Presymptomatic Parkinson’s Disease

Francisco Q. Gonçalves; Filipe C. Matheus; Henrique B. Silva; Joana I. Real; Daniel Rial; Rodrigues, Ricardo J.; Jean-Pierre Oses; et al, Molecular Neurobiology. 2022. . 10.1007/s12035-022-03162-1 . Molecular Neurobiology

P2Y1 Receptor as a Catalyst of Brain Neurodegeneration

Rodrigues, Ricardo J.; Ana S. Figueira; Joana M. Marques, NeuroSci. 604 - 615. 3. 2022. . 10.3390/neurosci3040043 . published NeuroSci

Restored Fyn Levels in Huntington’s Disease Contributes to Enhanced Synaptic GluN2B-Composed NMDA Receptors and CREB Activity

Lígia Fão; Patrícia Coelho; Rodrigues, Ricardo J.; A. Cristina Rego, Cells. 2022. . 10.3390/cells11193063 . Cells

Adenosine A2A receptors control synaptic remodeling in the adult brain

Rodrigues, Ricardo J.; Joana M Marques, Scientific Reports. 1. 12. 2022. . 10.1038/s41598-022-18884-4 . published Scientific Reports

Convergence of adenosine and GABA signaling for synapse stabilization during development

Gomez-Castro, Ferran; Zappettini, Stefania; Pressey, Jessica C.; Silva, Carla G.; Russeau, Marion; Gervasi, Nicolas; Figueiredo, Marta; et al, Science. 6568. 374. 2021. . 10.1126/science.abk2055 . published Science

Adenosine A2A Receptors Contribute to the Radial Migration of Cortical Projection Neurons through the Regulation of Neuronal Polarization and Axon Formation.

Rodrigues, Ricardo J.; Joana M Marques, Cerebral cortex (New York, N.Y. : 1991). 5652 - 5663. 12. 31. 2021. . 10.1093/cercor/bhab188 . published Cerebral cortex (New York, N.Y. : 1991)

Neurogenesis and Gliogenesis: Relevance of Adenosine for Neuroregeneration in Brain Disorders

Joana M. Mateus; Filipa F. Ribeiro; Marta Alonso-Gomes; Rui S. Rodrigues; Joana M. Marques; Ana M. Sebastião; Rodrigues, Ricardo J.; Sara Xapelli, Journal of Caffeine and Adenosine Research. 129 - 144. 4. 9. 2019. . 10.1089/caff.2019.0010 . published Journal of Caffeine and Adenosine Research

Glutamate-induced and NMDA receptor-mediated neurodegeneration entails P2Y1 receptor activation

Simões, A.P.; Silva, C.G.; Marques, J.M.; Pochmann, D.; Porciúncula, L.O.; Ferreira, S.; Oses, J.P.; et al, Cell Death and Disease. 3. 9. 2018. . 10.1038/s41419-018-0351-1 . published Cell Death and Disease

Purinergic signalling and brain development.

Rodrigues, Ricardo J.; Joana M Marques; Cunha RA, Seminars in cell & developmental biology. 34 - 41. 95. 2018. . 10.1016/j.semcdb.2018.12.001 . published Seminars in cell & developmental biology

P2 receptors control the migration of medial ganglionic eminence-derived interneurons

Ferreira, S.; Joana M Marques; Alcada-Morais, S.; Leyva-Diaz, E.; Lopez-Bendito, G.; Cunha, R. A.; Rodrigues, Ricardo J., Journal of Neurochemistry. 2017. . Journal of Neurochemistry

Antimicrobial peptide-gold nanoscale therapeutic formulation with high skin regenerative potential

Comune, M.; Rai, A.; Chereddy, K.K.; Pinto, S.; Aday, S.; Ferreira, A.F.; Zonari, A.; et al, Journal of Controlled Release. 58 - 71. 262. 2017. . 10.1016/j.jconrel.2017.07.007 . published Journal of Controlled Release

Hierarchical glucocorticoid-endocannabinoid interplay regulates the activation of the nucleus accumbens by insulin

Pinheiro, B.S.; Lemos, C.; Neutzling Kaufmann, F.; Marques, J.M.; da Silva-Santos, C.S.; Carvalho, E.; Mackie, K.; et al, Brain Research Bulletin. 222 - 230. 124. 2016. . 10.1016/j.brainresbull.2016.05.009 . published Brain Research Bulletin

High sucrose consumption induces memory impairment in rats associated with electrophysiological modifications but not with metabolic changes in the hippocampus

Lemos, C.; Rial, D.; Gonçalves, F.Q.; Pires, J.; Silva, H.B.; Matheus, F.C.; da Silva, A.C.; et al, Neuroscience. 196 - 205. 315. 2016. . 10.1016/j.neuroscience.2015.12.018 . published Neuroscience

Stimulation of brain glucose uptake by cannabinoid CB<inf>2</inf> receptors and its therapeutic potential in Alzheimer's disease

Köfalvi, A.; Lemos, C.; Martín-Moreno, A.M.; Pinheiro, B.S.; García-García, L.; Pozo, M.A.; Valério-Fernandes, Â.; et al, Neuropharmacology. 519 - 529. 110. 2016. . 10.1016/j.neuropharm.2016.03.015 . published Neuropharmacology

Presynaptic P2X1-3 and a3-containing nicotinic receptors assemble into functionally interacting ion channels in the rat hippocampus

Rodrigues, Ricardo J.; Almeida, T.; Díaz-Hernández, M.; Joana M Marques; Franco, R.; Solsona, C.; Miras-Portugal, M.T.; Ciruela, F.; Cunha, R.A., Neuropharmacology. 241 - 257. 105. 2016. . 10.1016/j.neuropharm.2016.01.022 . published Neuropharmacology

ATP as a multi-target danger signal in the brain

Rodrigues, Ricardo J.; Tomé, A.R.; Cunha, R.A., Frontiers in Neuroscience. APR. 9. 2015. . 10.3389/fnins.2015.00148 . published Frontiers in Neuroscience

Presynaptic adenosine a2A receptors dampen cannabinoid CB1 receptor-mediated inhibition of corticostriatal glutamatergic transmission

Ferreira, S.G.; Gonc¸alves, F.Q.; Joana M Marques; Tomé, Â.R.; Rodrigues, Ricardo J.; Nunes-Correia, I.; Ledent, C.; et al, British Journal of Pharmacology. 1074 - 1086. 4. 172. 2015. . 10.1111/bph.12970 . published British Journal of Pharmacology

Adenosine A<inf>2b</inf> receptors control A<inf>1</inf> receptor-mediated inhibition of synaptic transmission in the mouse hippocampus

Gonçalves, F.Q.; Pires, J.; Pliassova, A.; Beleza, R.; Lemos, C.; Joana M Marques; Rodrigues, Ricardo J.; et al, European Journal of Neuroscience. 876 - 886. 7. 41. 2015. . 10.1111/ejn.12851 . published European Journal of Neuroscience

Adenosine A<inf>2B</inf> receptor activation stimulates glucose uptake in the mouse forebrain

Lemos, C.; Pinheiro, B.S.; Beleza, R.O.; Joana M Marques; Rodrigues, Ricardo J.; Cunha, R.A.; Rial, D.; Köfalvi, A., Purinergic Signalling. 561 - 569. 4. 11. 2015. . 10.1007/s11302-015-9474-3 . published Purinergic Signalling

Predominant loss of glutamatergic terminal markers in a ß-amyloid peptide model of Alzheimer's disease

Canas, P.M.; Simões, A.P.; Rodrigues, Ricardo J.; Cunha, R.A., Neuropharmacology. 51 - 56. PART A. 76. 2014. . 10.1016/j.neuropharm.2013.08.026 . published Neuropharmacology

Synaptic and glia involvement in the purinergic control of neurodegenerative diseases

Canas, Paula M.; Rial, Daniel; Simoes, Ana Patricia; Lopes, Joao Pedro; Silva, Henrique B.; Machado, Nuno J.; Queiroz, Francisco; et al, Purinergic Signalling. 2014. . Purinergic Signalling

CRMP2 tethers kainate receptor activity to cytoskeleton dynamics during neuronal maturation

Joana M Marques; Rodrigues, Ricardo J.; Valbuena, S.; Rozas, J.L.; Selak, S.; Marin, P.; Aller, M.I.; Lerma, J., Journal of Neuroscience. 18298 - 18310. 46. 33. 2013. . 10.1523/JNEUROSCI.3136-13.2013 . published Journal of Neuroscience

Metabotropic signaling by kainate receptors

Rodrigues, Ricardo J.; Lerma, J., Wiley Interdisciplinary Reviews: Membrane Transport and Signaling. 399 - 410. 4. 1. 2012. . 10.1002/wmts.35 . published Wiley Interdisciplinary Reviews: Membrane Transport and Signaling

Enhanced role of adenosine A 2A receptors in the modulation of LTP in the rat hippocampus upon ageing

Costenla, A.R.; Diógenes, M.J.; Canas, P.M.; Rodrigues, Ricardo J.; Nogueira, C.; Maroco, J.; Agostinho, P.M.; et al, European Journal of Neuroscience. 12 - 21. 1. 34. 2011. . 10.1111/j.1460-9568.2011.07719.x . published European Journal of Neuroscience

Modification upon aging of the density of presynaptic modulation systems in the hippocampus

Canas, P.M.; Duarte, J.M.N.; Rodrigues, Ricardo J.; Köfalvi, A.; Cunha, R.A., Neurobiology of Aging. 1877 - 1884. 11. 30. 2009. . 10.1016/j.neurobiolaging.2008.01.003 . published Neurobiology of Aging


Cunha, Rodrigo A.; Almeida, Teresa; Rodrigues, Ricardo J.; Diaz-Hernandez, Miguel; Aleu, Jordi; Franco, Rafael; Solsona, Carles; Miras-Portugal, Maria-Teresa; Ciruela, Francisco, Journal of Physiological Sciences. 2009. . Journal of Physiological Sciences

Modification of adenosine modulation of acetylcholine release in the hippocampus of aged rats

Rodrigues, Ricardo J.; Canas, P.M.; Lopes, L.V.; Oliveira, C.R.; Cunha, R.A., Neurobiology of Aging. 1597 - 1601. 10. 29. 2008. . 10.1016/j.neurobiolaging.2007.03.025 . accepted Neurobiology of Aging

GABA release by basket cells onto Purkinje cells, in rat cerebellar slices, is directly controlled by presynaptic purinergic receptors, modulating Ca2+ influx

Donato, R.; Rodrigues, R.J.; Takahashi, M.; Tsai, M.C.; Soto, D.; Miyagi, K.; Villafuertes, R.G.; Cunha, R.A.; Edwards, F.A., Cell Calcium. 521 - 532. 6. 44. 2008. . 10.1016/j.ceca.2008.03.006 . published Cell Calcium

Electrophysiological and immunocytochemical evidence for P2X purinergic receptors in pancreatic ß cells

Silva, A.M.; Rodrigues, R.J.; Tomé, Â.R.; Cunha, R.A.; Misler, S.; Rosário, L.M.; Santos, R.M., Pancreas. 279 - 283. 3. 36. 2008. . 10.1097/MPA.0b013e31815a8473 . published Pancreas

Modification of purinergic signaling in the hippocampus of streptozotocin-induced diabetic rats

Duarte, J.M.N.; Oses, J.P.; Rodrigues, Ricardo J.; Cunha, R.A., Neuroscience. 382 - 391. 2. 149. 2007. . 10.1016/j.neuroscience.2007.08.005 . published Neuroscience

Anandamide and NADA bi-directionally modulate presynaptic Ca 2+ levels and transmitter release in the hippocampus

Köfalvi, A.; Pereira, M.F.; Rebola, N.; Rodrigues, R.J.; Oliveira, C.R.; Cunha, R.A., British Journal of Pharmacology. 551 - 563. 4. 151. 2007. . 10.1038/sj.bjp.0707252 . British Journal of Pharmacology

Differential glutamate-dependent and glutamate-independent adenosine A 1 receptor-mediated modulation of dopamine release in different striatal compartments

Borycz, J.; Pereira, M.F.; Melani, A.; Rodrigues, Ricardo J.; Köfalvi, A.; Panlilio, L.; Pedata, F.; et al, Journal of Neurochemistry. 355 - 363. 2. 101. 2007. . 10.1111/j.1471-4159.2006.04386.x . published Journal of Neurochemistry

Saccharomyces cerevisiae Hog1 protein phosphorylation upon exposure to bacterial endotoxin

Joana M Marques; Rodrigues, Ricardo J.; De Magalhães-Sant'Ana, A.C.; Gonçalves, T., Journal of Biological Chemistry. 24687 - 24694. 34. 281. 2006. . 10.1074/jbc.M603753200 . published Journal of Biological Chemistry

TrkB receptors modulation of glutamate release is limited to a subset of nerve terminals in the adult rat hippocampus

Pereira, D.B.; Rebola, N.; Rodrigues, Ricardo J.; Cunha, R.A.; Carvalho, A.P.; Duarte, C.B., Journal of Neuroscience Research. 832 - 844. 5. 83. 2006. . 10.1002/jnr.20784 . published Journal of Neuroscience Research

CB1 receptor antagonism increases hippocampal acetylcholine release: Site and mechanism of action

Degroot, A.; Köfalvi, A.; Wade, M.R.; Davis, R.J.; Rodrigues, Ricardo J.; Rebola, N.; Cunha, R.A.; Nomikos, G.G., Molecular Pharmacology. 1236 - 1245. 4. 70. 2006. . 10.1124/mol.106.024661 . published Molecular Pharmacology

Interaction between P2X and nicotinic acetylcholine receptors in glutamate nerve terminals of the rat hippocampus

Rodrigues, Ricardo J.; Almeida, T.; De Mendonça, A.; Cunha, R.A., Journal of Molecular Neuroscience. 173 - 176. 1-2. 30. 2006. . 10.1385/JMN:30:1:173 . published Journal of Molecular Neuroscience

Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers

Ciruela, F.; Casadó, V.; Rodrigues, Ricardo J.; Luján, R.; Burgueño, J.; Canals, M.; Borycz, J.; et al, Journal of Neuroscience. 2080 - 2087. 7. 26. 2006. . 10.1523/JNEUROSCI.3574-05.2006 . published Journal of Neuroscience

Presynaptic kainate receptors are localized close to release sites in rat hippocampal synapses

Pinheiro, P.S.; Rodrigues, Ricardo J.; Rebola, N.; Xapelli, S.; Oliveira, C.R.; Malva, J.O., Neurochemistry International. 309 - 316. 5. 47. 2005. . 10.1016/j.neuint.2005.05.007 . published Neurochemistry International

Involvement of cannabinoid receptors in the regulation of neurotransmitter release in the rodent striatum: A combined immunochemical and pharmacological analysis

Köfalvi, A.; Rodrigues, R.J.; Ledent, C.; Mackie, K.; Vizi, E.S.; Cunha, R.A.; Sperlágh, B., Journal of Neuroscience. 2874 - 2884. 11. 25. 2005. . 10.1523/JNEUROSCI.4232-04.2005 . published Journal of Neuroscience

Different roles of adenosine A1, A2A and A 3 receptors in controlling kainate-induced toxicity in cortical cultured neurons

Rebola, N.; Rodrigues, R.J.; Oliveira, C.R.; Cunha, R.A., Neurochemistry International. 317 - 325. 5. 47. 2005. . 10.1016/j.neuint.2005.05.009 . published Neurochemistry International

Co-localization and functional interaction between adenosine A2A and metabotropic group 5 receptors in glutamatergic nerve terminals of the rat striatum

Rodrigues, Ricardo J.; Alfaro, T.M.; Rebola, N.; Oliveira, C.R.; Cunha, R.A., Journal of Neurochemistry. 433 - 441. 3. 92. 2005. . 10.1111/j.1471-4159.2004.02887.x . published Journal of Neurochemistry

Adenosine A1 and A2A receptors are co-expressed in pyramidal neurons and co-localized in glutamatergic nerve terminals of the rat hippocampus

Rebola, N.; Rodrigues, Ricardo J.; Lopes, L.V.; Richardson, P.J.; Oliveira, C.R.; Cunha, R.A., Neuroscience. 79 - 83. 1. 133. 2005. . 10.1016/j.neuroscience.2005.01.054 . published Neuroscience

Purinergic control of GABA release

Donato, R; Rodrigues, RJ; Cunha, R; Edwards, FA, Journal of Neurochemistry. 2005. . Journal of Neurochemistry

Dual presynaptic control by ATP of glutamate release via facilitatory P2X1, P2X2/3, and P2X3 and inhibitory P2Y 1, P2Y2, and/or P2Y4 receptors in the rat hippocampus

Rodrigues, Ricardo J.; Almeida, T.; Richardson, P.J.; Oliveira, C.R.; Cunha, R.A., Journal of Neuroscience. 6286 - 6295. 27. 25. 2005. . 10.1523/JNEUROSCI.0628-05.2005 . published Journal of Neuroscience

Release and neuromodulatory role of ATP in hippocampal synapses

Rodrigues, R. J.; Oliveira, C. R.; Cunha, R. A., Fundamental & Clinical Pharmacology. 2004. . Fundamental & Clinical Pharmacology

Comparative immunochemical and pharmacological investigation of the functional CB1 receptors in the Rodent striatum

Koefalvi, A.; Rodrigues, R. J.; Cunha, R. A.; Ledent, C.; Vizi, E. S.; Sperlagh, B., Fundamental & Clinical Pharmacology. 2004. . Fundamental & Clinical Pharmacology

Solubilization and immunological identification of presynaptic a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors in the rat hippocampus

Pinheiro, P.S.; Rodrigues, R.J.; Silva, A.P.; Cunha, R.A.; Oliveira, C.R.; Malva, J.O., Neuroscience Letters. 97 - 100. 2. 336. 2003. . 10.1016/S0304-3940(02)01217-X . published Neuroscience Letters

Purinergic P2 receptors trigger adenosine release leading to adenosine A2A receptor activation and facilitation of long-term potentiation in rat hippocampal slices

Almeida, T.; Rodrigues, Ricardo J.; De Mendonça, A.; Ribeiro, J.A.; Cunha, R.A., Neuroscience. 111 - 121. 1. 122. 2003. . 10.1016/S0306-4522(03)00523-2 . published Neuroscience

All projects

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Information of exclusive responsibility of the researcher 24-09-2023 , from platform CIÊNCIAVITAE.

2023/03 - 2024/08

Role of adenosine P1 receptors in the control of cortical neurons migration – the first unilateral mechanism in brain development?


Principal investigator

Associação para o Desenvolvimento da Imagiologia nos Hospitais da Universidade de Coimbra

Funders: Fundação para a Ciência e Tecnologia

2018/07/06 - 2021/07/05

A2A receptors control axon formation during neuronal development: new strategies to arrest epileptogenesis


Co-Principal Investigator (Co-PI)

Centro de Neurociências e Biologia Celular, Universidade de Coimbra

Funders: Fundação para a Ciência e a Tecnologia

2018/06 - 2021/12

iPS cells-derived exosomes - impact on mitochondrial (dys)function in Huntington's disease and potential nanodelivery system for microRNA-based therapeutics



Funders: Fundação para a Ciência e a Tecnologia

2016/01 - 2018/06

Hybrid ionotropic receptors: a new concept of receptor

Provided by PTCRIS: 142196

Principal investigator


Funders: Fundação para a Ciência e a Tecnologia, I.P.

2015/11 - 2017/10

P2Y1R-CRMP2 control synaptic and memory loss in early Alzheimer's disease


Principal investigator

Centro de Neurociências e Biologia Celular, Universidade de Coimbra

Funders: Alzheimer Association

2013/03 - 2014/04

Role of P2Y1 receptors on neuronal polarity and axonal growth: implications for mossy fiber sprouting in epileptic phenomena.

Provided by PTCRIS: 126861

Principal investigator

Funders: Fundação para a Ciência e a Tecnologia, I.P.

2013/09 - 2016/08

Role of P2Y1R in mossy fiber sprouting - new strategies to arrest epileptogenesis.

M.Curie: Cycle 4-2013-PT-07

Principal investigator

Funders: European Comission - Erasmus Mundus - ENC-Network

2012/05 - 2014/08

Physiopathological role of ecto-5`-nucleotidase - a new target for neuroprotection



Funders: Fundação para a Ciência e a Tecnologia, I.P.

2011 - 2016

Role of kainate receptors in health and disease



Instituto de Neurociencias

Funders: España Ministerio de Ciencia e Innovación

2009/12 - 2011/12

Role of KAR-CRMP2 interaction in neurodevelopment



Funders: Ministerio de Ciencia y Innovacion - Subprograma Juan de la Cierva

2007/07 - 2009/10


Provided by PTCRIS: 74318


Funders: Fundação para a Ciência e a Tecnologia, I.P.

2007/10/01 - 2009/09/30



Post-doc Fellow

Instituto de Neurociencias

Funders: Fundação para a Ciência e a Tecnologia

2005/01 - 2007/02

Control by adenosine of neuro-inflammation



Funders: Fundação para a Ciência e a Tecnologia, I.P.

2005/01 - 2007/02




Funders: Fundação para a Ciência e a Tecnologia, I.P.

2005/01 - 2007/02

Characterization of purinergic receptors in hippocampal mossy fibers - role in epilepsy

Provided by PTCRIS: 59135


Funders: Fundação para a Ciência e a Tecnologia, I.P.

2005/10 - 2007/12

Modification by chronic caffeine consumption of adenosine neuromodulation in the hippocampus - possible relevance for learning and memory



Funders: Fundação para a Ciência e a Tecnologia, I.P.

2003/10/01 - 2007/09/01

Role of ATP (P2) receptors in the control of neuronal function in the rat hippocampus CA3 area:pre- and postsynaptic effects in physiological and epileptic phenomena


PhD Student Fellow

Centro de Neurociências e Biologia Celular, Universidade de Coimbra

Funders: Fundação para a Ciência e a Tecnologia

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