Sandra Morais Cardoso

Team icon

Overview

Sandra Morais Cardoso is Assistant Professor at the Faculty of Medicine and leader of the 'GAin' group at CNC. Her research is focused on the role of microbiome-mitochondria crosstalk in the activation of neuronal innate immunity and on its impact in neurocircuitry in Neurodegenerative and Neuropsychiatric disorders. She published over 90 articles (index H = 48;> 16,000 citations), received the Medal of Merit from the Ministry of Health (2013), the Janssen Neuroscience Award (2014) and the Mantero Belard Award (2016) by SCML.

Affiliation

Faculty of Medicine and Center for Neuroscience and Cell Biology, University of Coimbra

Microbial BMAA elicits mitochondrial dysfunction, innate immunity activation, and Alzheimer’s disease features in cortical neurons

Silva, Diana F.; Candeias, Emanuel; Esteves, A. Raquel; Magalhães, João D.; Ferreira, I. Luísa; Nunes-Costa, Daniela; Rego, A. Cristina; Empadinhas, Nuno; Cardoso, Sandra M., Journal of Neuroinflammation. 1. 17. 2020. http://dx.doi.org/10.1186/s12974-020-02004-y . 10.1186/s12974-020-02004-y . published Journal of Neuroinflammation

Design, Synthesis, and In Vitro Evaluation of Hydroxybenzimidazole-Donepezil Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer’s Disease

Chaves, Sílvia; Resta, Simonetta; Rinaldo, Federica; Costa, Marina; Josselin, Romane; Gwizdala, Karolina; Piemontese, Luca; et al, Molecules. 4. 25. 2020. http://dx.doi.org/10.3390/molecules25040985 . 10.3390/molecules25040985 . Molecules

Novel tacrine–benzofuran hybrids as potential multi-target drug candidates for the treatment of Alzheimer’s Disease

Fancellu, Gaia; Chand, Karam; Tomás, Daniel; Orlandini, Elisabetta; Piemontese, Luca; Silva, Diana F.; Cardoso, Sandra M.; Chaves, Sílvia; Santos, M. Amélia, Journal of Enzyme Inhibition and Medicinal Chemistry. 211 - 226. 1. 35. 2020. http://dx.doi.org/10.1080/14756366.2019.1689237 . 10.1080/14756366.2019.1689237 . Journal of Enzyme Inhibition and Medicinal Chemistry

Microbial BMAA and the Pathway for Parkinson’s Disease Neurodegeneration

Nunes-Costa, Daniela; Magalhães, João Duarte; G-Fernandes, Maria; Cardoso, Sandra Morais; Empadinhas, Nuno, Frontiers in Aging Neuroscience. 12. 2020. http://dx.doi.org/10.3389/fnagi.2020.00026 . 10.3389/fnagi.2020.00026 . Frontiers in Aging Neuroscience

Donepezil-based hybrids as multifunctional anti-Alzheimer's disease chelating agents: Effect of positional isomerization

Costa, Marina; Josselin, Romane; Silva, Diana F.; Cardoso, Sandra M.; May, Nóra V.; Chaves, Sílvia; Santos, M. Amélia, Journal of Inorganic Biochemistry. 2020. http://dx.doi.org/10.1016/j.jinorgbio.2020.111039 . 10.1016/j.jinorgbio.2020.111039 . Journal of Inorganic Biochemistry

The Role of Beclin-1 Acetylation on Autophagic Flux in Alzheimer’s Disease

A. Raquel Esteves; Filipa Filipe; João D. Magalhães; Diana F. Silva; Sandra M. Cardoso, Molecular Neurobiology. 5654 - 5670. 8. 56. 2019. https://doi.org/10.1007/s12035-019-1483-8 . 10.1007/s12035-019-1483-8 . Molecular Neurobiology

Is Alzheimer’s disease an inflammasomopathy?

Pereira, Claudia F.; Santos, Armanda E.; Moreira, Paula I.; Pereira, Ana Catarina; Sousa, Fabio J.; Cardoso, Sandra M.; Cruz, M. Teresa, Ageing Research Reviews. 56. 2019. http://dx.doi.org/10.1016/j.arr.2019.100966 . 10.1016/j.arr.2019.100966 . Ageing Research Reviews

Acetylation as a major determinant to microtubule-dependent autophagy: Relevance to Alzheimer's and Parkinson disease pathology

Esteves, A.R.; Palma, A.M.; Gomes, R.; Santos, D.; Silva, D.F.; Cardoso, S.M., Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2008 - 2023. 8. 1865. 2019. http://dx.doi.org/10.1016/j.bbadis.2018.11.014 . 10.1016/j.bbadis.2018.11.014 . Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

New Multitarget Hybrids Bearing Tacrine and Phenylbenzothiazole Motifs as Potential Drug Candidates for Alzheimer’s Disease

Rajeshwari Rajeshwari; karam Chand; Emanuel Candeias; Cardoso SM; Sílvia Chaves; M. A. Santos, Molecules. 2019. http://www.mdpi.com/1420-3049/24/3/587 . 10.3390/molecules24030587 . Molecules

Novel Tacrine-Hydroxyphenylbenzimidazole hybrids as potential multitarget drug candidates for Alzheimer's disease

Hiremathad, Asha; Keri, Rangappa S.; Esteves, A. Raquel; Cardoso, Sandra M.; Chaves, Sílvia; Santos, M. Amélia, European Journal of Medicinal Chemistry. 255 - 267. 148. 2018. http://dx.doi.org/10.1016/j.ejmech.2018.02.023 . 10.1016/j.ejmech.2018.02.023 . European Journal of Medicinal Chemistry

Hydroxypyridinone-benzofuran hybrids with potential protective roles for Alzheimer´s disease therapy.

Hiremathad A; Chand K; Tolayan L; Rajeshwari; Keri RS; Esteves AR; Cardoso SM; Chaves S; Santos MA, Journal of inorganic biochemistry. 2018. http://europepmc.org/abstract/med/29182921 . 10.1016/j.jinorgbio.2017.11.015 . Journal of inorganic biochemistry

Donepezil structure-based hybrids as potential multifunctional anti-Alzheimer’s drug candidates

Luca Piemontese; Daniel Tomás; Asha Hiremathad; Vito Capriati; Emanuel Candeias; Sandra M. Cardoso; Sílvia Chaves; M. Amélia Santos, Journal of Enzyme Inhibition and Medicinal Chemistry. 1212 - 1224. 1. 33. 2018. https://doi.org/10.1080/14756366.2018.1491564 . 10.1080/14756366.2018.1491564 . Journal of Enzyme Inhibition and Medicinal Chemistry

Tacrine–deferiprone hybrids as multi-target-directed metal chelators against Alzheimer's disease: a two-in-one drug

Karam Chand; Rajeshwari Rajeshwari; Emanuel Candeias; Sandra M. Cardoso; Sílvia Chaves; M. Amélia Santos, Metallomics. 1460 - 1475. 10. 10. 2018. https://doi.org/10.1039/C8MT00143J . 10.1039/C8MT00143J . Metallomics

The Microbiome-Mitochondria Dance in Prodromal Parkinson’s Disease

Cardoso, Sandra M.; Empadinhas, Nuno, Frontiers in Physiology. 9. 2018. http://dx.doi.org/10.3389/fphys.2018.00471 . 10.3389/fphys.2018.00471 . Frontiers in Physiology

Mild Exercise Differently Affects Proteostasis and Oxidative Stress on Motor Areas During Neurodegeneration: A Comparative Study of Three Treadmill Running Protocols

Melo, Karla P.; Silva, Carolliny M.; Almeida, Michael F.; Chaves, Rodrigo S.; Marcourakis, Tania; Cardoso, Sandra M.; Demasi, Marilene; Netto, Luis E. S.; Ferrari, Merari F. R., Neurotoxicity Research. 410 - 420. 2. 35. 2018. http://dx.doi.org/10.1007/s12640-018-9966-3 . 10.1007/s12640-018-9966-3 . Neurotoxicity Research

Mitochondrial Metabolism Power SIRT2-Dependent Deficient Traffic Causing Alzheimer's-Disease Related Pathology.

Cardoso SM, 2017. http://europepmc.org/abstract/med/27311773 .

Effects of mild running on substantia nigra during early neurodegeneration.

Almeida MF; Silva CM; Chaves RS; Lima NCR; Almeida RS; Melo KP; Demasi M; et al, Journal of sports sciences. 2017. http://europepmc.org/abstract/med/28895489 . 10.1080/02640414.2017.1378494 . Journal of sports sciences

LRRK2 at the Crossroad Between Autophagy and Microtubule Trafficking: Insights into Parkinson's Disease.

Esteves AR; Cardoso SM, 2016. http://europepmc.org/abstract/med/26740081 .

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Klionsky DJ; Abdelmohsen K; Abe A; Abedin MJ; Abeliovich H; Acevedo Arozena A; Adachi H; et al, 2016. http://europepmc.org/abstract/med/26799652 . 10.1080/15548627.2015.1100356 .

New Tacrine Hybrids with Natural-Based Cysteine Derivatives as Multitargeted Drugs for Potential Treatment of Alzheimer's Disease.

Keri RS; Quintanova C; Chaves S; Silva DF; Cardoso SM; Santos MA, 2016. http://europepmc.org/abstract/med/26256122 . 10.1111/cbdd.12633 .

Tacrine-allyl/propargylcysteine-benzothiazole trihybrids as potential anti-Alzheimer´s drug candidates

Sandra Morais Cardoso, RSC Advances . 2016. https://pubs.rsc.org/en/content/articlelanding/2016/ra/c6ra03455a#!divCitation . published RSC Advances

The role of proteotoxic stress in vascular dysfunction in the pathogenesis of Alzheimer’s disease

Fonseca, Ana Catarina R.G.; Resende, Rosa; Cardoso, Sandra M.; Pereira, Cláudia F., Endoplasmic Reticulum Stress in Diseases. 1. 2. 2015. http://dx.doi.org/10.1515/ersc-2015-0005 . 10.1515/ersc-2015-0005 . Endoplasmic Reticulum Stress in Diseases

Design, Synthesis and Bioevaluation of Tacrine Hybrids with Cinnamate and Cinnamylideneacetate Derivatives as Potential Anti-Alzheimer Drug Candidates

Sandra Morais Cardoso, Medicinal Chemical Communications. 2015. https://pubs.rsc.org/en/content/articlelanding/2015/MD/c5md00236b#!divAbstract . published Medicinal Chemical Communications

The Upshot of LRRK2 Inhibition to Parkinson's Disease Paradigm.

Esteves AR; G-Fernandes M; Santos D; Januário C; Cardoso SM, 2015. http://europepmc.org/abstract/med/25394383 . 10.1007/s12035-014-8980-6 .

The Impact of Mitochondrial Fusion and Fission Modulation in Sporadic Parkinson's Disease.

Santos D; Esteves AR; Silva DF; Januário C; Cardoso SM, 2015. http://europepmc.org/abstract/med/25218511 . 10.1007/s12035-014-8893-4 .

Special focus on autophagy.

Cardoso SM, 2015. http://europepmc.org/abstract/med/25844484 . 10.1089/dna.2015.1501 .

Calcium and redox homeostasis in Alzheimer's disease: a focus on the endoplasmic reticulum

Sandra Morais Cardoso; Fonseca AC, Therapeutic Targets for Neurological Diseases. 2015. http://dx.doi.org/10.14800/ttnd.428 . 10.14800/ttnd.428 . Therapeutic Targets for Neurological Diseases

Loss of proteostasis induced by amyloid beta peptide in brain endothelial cells

Fonseca, A.C.; Oliveira, C.R.; Pereira, C.F.; Cardoso, S.M., Biochimica et Biophysica Acta - Molecular Cell Research. 1150 - 1161. 6. 1843. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84896111540&partnerID=MN8TOARS . 10.1016/j.bbamcr.2014.02.016 . Biochimica et Biophysica Acta - Molecular Cell Research

The rescue of microtubule-dependent traffic recovers mitochondrial function in Parkinson's disease

Esteves, A.R.; Gozes, I.; Cardoso, S.M., Biochimica et Biophysica Acta - Molecular Basis of Disease. 7 - 21. 1. 1842. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887706170&partnerID=MN8TOARS . 10.1016/j.bbadis.2013.10.003 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Amyloid-Beta Disrupts Calcium and Redox Homeostasis in Brain Endothelial Cells

Fonseca, A.C.R.G.; Moreira, P.I.; Oliveira, C.R.; Cardoso, S.M.; Pinton, P.; Pereira, C.F., Molecular Neurobiology. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901537197&partnerID=MN8TOARS . 10.1007/s12035-014-8740-7 . Molecular Neurobiology

LRRK2, a puzzling protein: Insights into Parkinson's disease pathogenesis

Esteves, A.R.; Swerdlow, R.H.; Cardoso, S.M., Experimental Neurology. 206 - 216. 261. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84905511765&partnerID=MN8TOARS . 10.1016/j.expneurol.2014.05.025 . Experimental Neurology

The role of endoplasmic reticulum in amyloid precursor protein processing and trafficking: Implications for Alzheimer's disease

Plácido, A.I.; Pereira, C.M.F.; Duarte, A.I.; Candeias, E.; Correia, S.C.; Santos, R.X.; Carvalho, C.; et al, Biochimica et Biophysica Acta - Molecular Basis of Disease. 1444 - 1453. 9. 1842. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903458925&partnerID=MN8TOARS . 10.1016/j.bbadis.2014.05.003 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Activation of the endoplasmic reticulum stress response by the amyloid-beta 1-40 peptide in brain endothelial cells

Fonseca, A.C.R.G.; Ferreiro, E.; Oliveira, C.R.; Cardoso, S.M.; Pereira, C.F., Biochimica et Biophysica Acta - Molecular Basis of Disease. 2191 - 2203. 12. 1832. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883780939&partnerID=MN8TOARS . 10.1016/j.bbadis.2013.08.007 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Mitochondria drive autophagy pathology via microtubule disassembly: A new hypothesis for Parkinson disease

Arduíno, D.M.; Esteves, A.R.; Cardoso, S.M., Autophagy. 112 - 114. 1. 9. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872195238&partnerID=MN8TOARS . 10.4161/auto.22443 . Autophagy

Prodromal metabolic phenotype in MCI cybrids: Implications for Alzheimer's disease

Silva, D.F.; Santana, I.; Esteves, A.R.; Baldeiras, I.; Arduino, D.M.; Oliveira, C.R.; Cardoso, S.M., Current Alzheimer Research. 180 - 190. 2. 10. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875000768&partnerID=MN8TOARS . 10.2174/1567205011310020008 . Current Alzheimer Research

Multifunctional iron-chelators with protective roles against neurodegenerative diseases

Nunes, A.; Marques, S.M.; Quintanova, C.; Silva, D.F.; Cardoso, S.M.; Chaves, S.; Santos, M.A., Dalton Transactions. 6058 - 6073. 17. 42. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875780884&partnerID=MN8TOARS . 10.1039/c3dt50406a . Dalton Transactions

Design, synthesis and neuroprotective evaluation of novel tacrine-benzothiazole hybrids as multi-targeted compounds against Alzheimer's disease

Keri, R.S.; Quintanova, C.; Marques, S.M.; Esteves, A.R.; Cardoso, S.M.; Santos, M.A., Bioorganic and Medicinal Chemistry. 4559 - 4569. 15. 21. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879689184&partnerID=MN8TOARS . 10.1016/j.bmc.2013.05.028 . Bioorganic and Medicinal Chemistry

Bioenergetic flux, mitochondrial mass and mitochondrial morphology dynamics in AD and MCI cybrid cell lines

Silva, D.F.; Selfridge, J.E.; Lu, J.; Lezi, E.; Roy, N.; Hutfles, L.; Burns, J.M.; et al, Human Molecular Genetics. 3931 - 3946. 19. 22. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84888799219&partnerID=MN8TOARS . 10.1093/hmg/ddt247 . Human Molecular Genetics

Mitochondrial dynamics and neuronal fate in Parkinson's disease

Santos, D.; Cardoso, S.M., Mitochondrion. 428 - 437. 4. 12. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861695750&partnerID=MN8TOARS . 10.1016/j.mito.2012.05.002 . Mitochondrion

Amyloid ß-induced ER stress is enhanced under mitochondrial dysfunction conditions

Costa, R.O.; Ferreiro, E.; Martins, I.; Santana, I.; Cardoso, S.M.; Oliveira, C.R.; Pereira, C.M.F., Neurobiology of Aging. 4. 33. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856951448&partnerID=MN8TOARS . 10.1016/j.neurobiolaging.2011.04.011 . Neurobiology of Aging

Guidelines for the use and interpretation of assays for monitoring autophagy

Klionsky, D.J.; Abdalla, F.C.; Abeliovich, H.; Abraham, R.T.; Acevedo-Arozena, A.; Adeli, K.; Agholme, L.; et al, Autophagy. 445 - 544. 4. 8. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862295360&partnerID=MN8TOARS . 10.4161/auto.19496 . Autophagy

Mitochondrial metabolic control of microtubule dynamics impairs the autophagic pathway in Parkinson's disease

Cardoso, S.M.; Esteves, A.R.; Arduno, D.M., Neurodegenerative Diseases. 38 - 40. 1-4. 10. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860223145&partnerID=MN8TOARS . 10.1159/000332601 . Neurodegenerative Diseases

Cyanide preconditioning protects brain endothelial and NT2 neuron-like cells against glucotoxicity: Role of mitochondrial reactive oxygen species and HIF-1a

Correia, S.C.; Santos, R.X.; Cardoso, S.M.; Santos, M.S.; Oliveira, C.R.; Moreira, P.I., Neurobiology of Disease. 206 - 218. 1. 45. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-81955160758&partnerID=MN8TOARS . 10.1016/j.nbd.2011.08.005 . Neurobiology of Disease

Mitochondrial metabolism in Parkinson's disease impairs quality control autophagy by hampering microtubule-dependent traffic

Arduíno, D.M.; Esteves, A.R.; Cortes, L.; Silva, D.F.; Patel, B.; Grazina, M.; Swerdlow, R.H.; Oliveira, C.R.; Cardoso, S.M., Human Molecular Genetics. 4680 - 4702. 21. 21. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867828156&partnerID=MN8TOARS . 10.1093/hmg/dds309 . Human Molecular Genetics

Ubiquitin proteasome system in Parkinson's disease: A keeper or a witness?

Martins-Branco, D.; Esteves, A.R.; Santos, D.; Arduino, D.M.; Swerdlow, R.H.; Oliveira, C.R.; Januario, C.; Cardoso, S.M., Experimental Neurology. 89 - 99. 2. 238. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866521159&partnerID=MN8TOARS . 10.1016/j.expneurol.2012.08.008 . Experimental Neurology

Therapeutic intervention at cellular quality control systems in Alzheimer's and Parkinson's diseases

Arduino, D.M.; Esteves, A.R.; Silva, D.F.F.; Martins-Branco, D.; Santos, D.; Pimentel, D.F.G.; Cardoso, S.M., Current Pharmaceutical Design. 3446 - 3459. 31. 17. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80055080733&partnerID=MN8TOARS . 10.2174/138161211798072481 . Current Pharmaceutical Design

The mitochondrial cascade hypothesis for parkinson's disease

Cardoso, S.M., Current Pharmaceutical Design. 3390 - 3397. 31. 17. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80055076405&partnerID=MN8TOARS . 10.2174/138161211798072508 . Current Pharmaceutical Design

Mitochondrial fusion/fission, transport and autophagy in Parkinson's disease: When mitochondria get nasty

Arduíno, D.M.; Esteves, A.R.; Cardoso, S.M., Parkinson's Disease. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953286639&partnerID=MN8TOARS . 10.4061/2011/767230 . Parkinson's Disease

Mitochondria: The common upstream driver of amyloid-ß and tau pathology in Alzheimers disease

Silva, D.F.F.; Esteves, A.R.; Oliveira, C.R.; Cardoso, S.M., Current Alzheimer Research. 563 - 572. 5. 8. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79959926983&partnerID=MN8TOARS . 10.2174/156720511796391872 . Current Alzheimer Research

Bifunctional phenolic-choline conjugates as anti-oxidants and acetylcholinesterase inhibitors

Šebestík, J.; Marques, S.M.; Falé, P.L.; Santos, S.; Arduíno, D.M.; Cardoso, S.M.; Oliveira, C.R.; Serralheiro, M.L.M.; Santos, M.A., Journal of Enzyme Inhibition and Medicinal Chemistry. 485 - 497. 4. 26. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79959882783&partnerID=MN8TOARS . 10.3109/14756366.2010.529806 . Journal of Enzyme Inhibition and Medicinal Chemistry

Amyloid-ß-induced mitochondrial dysfunction impairs the autophagic lysosomal pathway in a tubulin dependent pathway

Silva, D.F.F.; Esteves, A.R.; Arduino, D.M.; Oliveira, C.R.; Cardoso, S.M., Journal of Alzheimer's Disease. 565 - 581. 3. 26. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80053559887&partnerID=MN8TOARS . 10.3233/JAD-2011-110423 . Journal of Alzheimer's Disease

Mitochondrial dysfunction: The road to alpha-synuclein oligomerization in PD

Cardoso, S.M.; Esteves, A.R.; Arduíno, D.M.; Silva, D.F.F.; Oliveira, C.R., Parkinson's Disease. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952169319&partnerID=MN8TOARS . 10.4061/2011/693761 . Parkinson's Disease

SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1a Destabilization

Finley, L.; Carracedo, A.; Lee, J.; Souza, A.; Egia, A.; Zhang, J.; Teruya-Feldstein, J.; et al, Cancer Cell. 416 - 428. 3. 19. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952501323&partnerID=MN8TOARS . 10.1016/j.ccr.2011.02.014 . Cancer Cell

Mitochondrial respiration and respiration-associated proteins in cell lines created through Parkinson's subject mitochondrial transfer

Esteves, A.R.; Lu, J.; Rodova, M.; Onyango, I.; Lezi, E.; Dubinsky, R.; Lyons, K.E.; et al, Journal of Neurochemistry. 674 - 682. 3. 113. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77950661030&partnerID=MN8TOARS . 10.1111/j.1471-4159.2010.06631.x . Journal of Neurochemistry

Mitochondrial control of autophagic lysosomal pathway in Alzheimer's disease

Cardoso, S.M.; Pereira, C.F.; Moreira, P.I.; Arduino, D.M.; Esteves, A.R.; Oliveira, C.R., Experimental Neurology. 294 - 298. 2. 223. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952549554&partnerID=MN8TOARS . 10.1016/j.expneurol.2009.06.008 . Experimental Neurology

Dysfunctional mitochondria uphold calpain activation: Contribution to Parkinson's disease pathology

Esteves, A.R.; Arduíno, D.M.; Swerdlow, R.H.; Oliveira, C.R.; Cardoso, S.M., Neurobiology of Disease. 723 - 730. 3. 37. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-75949120541&partnerID=MN8TOARS . 10.1016/j.nbd.2009.12.011 . Neurobiology of Disease

Microtubule depolymerization potentiates alpha-synuclein oligomerization

Esteves, A. Raquel, Frontiers in Aging Neuroscience. 1. 2010. http://dx.doi.org/10.3389/neuro.24.005.2009 . 10.3389/neuro.24.005.2009 . Frontiers in Aging Neuroscience

Cross-talk between mitochondria and proteasome in Parkinson's disease pathogenesis

Branco, D.M.; Arduino, D.M.; Raquel Esteves, A.; Silva, D.F.F.; Cardoso, S.M.; Oliveira, C.R., Frontiers in Aging Neuroscience. MAY. 2. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957350452&partnerID=MN8TOARS . 10.3389/fnagi.2010.00017 . Frontiers in Aging Neuroscience

Mitochondrial-dependent apoptosis in Huntington's disease human cybrids

Ferreira, I.L.; Nascimento, M.V.; Ribeiro, M.; Almeida, S.; Cardoso, S.M.; Grazina, M.; Pratas, J.; et al, Experimental Neurology. 243 - 255. 2. 222. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77549084450&partnerID=MN8TOARS . 10.1016/j.expneurol.2010.01.002 . Experimental Neurology

ER stress-mediated apoptotic pathway induced by aß peptide requires the presence of functional mitochondria

Costa, R.O.; Ferreiro, E.; Cardoso, S.M.; Oliveira, C.R.; Pereira, C.M.F., Journal of Alzheimer's Disease. 625 - 636. 2. 20. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954516455&partnerID=MN8TOARS . 10.3233/JAD-2010-091369 . Journal of Alzheimer's Disease

Mitochondrial metabolism modulation: A new therapeutic approach for Parkinson's disease

Arduíno, D.M.; Esteves, A.R.; Oliveira, C.R.; Cardoso, S.M., CNS and Neurological Disorders - Drug Targets. 105 - 119. 1. 9. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77949908141&partnerID=MN8TOARS . CNS and Neurological Disorders - Drug Targets

Polymorphic variation in cytochrome oxidase subunit genes

Lu, J.; Wang, K.; Rodova, M.; Esteves, R.; Berry, D.; Lezi, E.L.; Crafter, A.; et al, Journal of Alzheimer's Disease. 141 - 154. 1. 21. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954963850&partnerID=MN8TOARS . 10.3233/JAD-2010-100123 . Journal of Alzheimer's Disease

Mitochondria as a therapeutic target in Alzheimer's disease and diabetes

Moreira, P.I.; Cardoso, S.M.; Pereira, C.M.; Santos, M.S.; Oliveira, C.R., CNS and Neurological Disorders - Drug Targets. 492 - 511. 6. 8. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-75849136180&partnerID=MN8TOARS . 10.2174/187152709789824651 . CNS and Neurological Disorders - Drug Targets

ER-mediated stress induces mitochondrial-dependent caspases activation in NT2 neuron-like cells

Arduíno, D.M.; Raquel Esteves, A.; Filipa Domingues, A.; Pereira, C.M.F.; Cardoso, S.M.; Oliveira, C.R., BMB Reports. 719 - 724. 11. 42. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-73449102905&partnerID=MN8TOARS . BMB Reports

Endoplasmic reticulum and mitochondria interplay mediates apoptotic cell death: Relevance to Parkinson's disease

Arduíno, D.M.; Esteves, A.R.; Cardoso, S.M.; Oliveira, C.R., Neurochemistry International. 341 - 348. 5. 55. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-67649342203&partnerID=MN8TOARS . 10.1016/j.neuint.2009.04.004 . Neurochemistry International

Oxidative stress involvement in a-synuclein oligomerization in Parkinson's disease cybrids

Esteves, A.R.; Arduíno, D.M.; Swerdlow, R.H.; Oliveira, C.R.; Cardoso, S.M., Antioxidants and Redox Signaling. 439 - 448. 3. 11. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-58849086657&partnerID=MN8TOARS . 10.1089/ars.2008.2247 . Antioxidants and Redox Signaling

New hydroxypyridinone iron-chelators as potential anti-neurodegenerative drugs

Arduino, D.; Silva, D.; Cardoso, S.M.; Chaves, S.; Oliveira, C.R.; Santos, M.A., Frontiers in Bioscience. 6763 - 6774. 17. 13. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-52049107811&partnerID=MN8TOARS . Frontiers in Bioscience

Calpain-mediated MPP+ toxicity in mitochondrial DNA depleted cells

Domingues, A.F.; Esteves, A.R.F.; Swerdlow, R.H.; Oliveira, C.R.; Cardoso, S.M., Neurotoxicity Research. 31 - 38. 1. 13. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-44649157955&partnerID=MN8TOARS . 10.1007/BF03033365 . Neurotoxicity Research

Mitochondrial function in Parkinson's disease cybrids containing an nt2 neuron-like nuclear background

Esteves, A.R.F.; Domingues, A.F.; Ferreira, I.L.; Januário, C.; Swerdlow, R.H.; Oliveira, C.R.; Cardoso, S.M., Mitochondrion. 219 - 228. 3. 8. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-45449100897&partnerID=MN8TOARS . 10.1016/j.mito.2008.03.004 . Mitochondrion

Involvement of mitochondria in endoplasmic reticulum stress-induced apoptotic cell death pathway triggered by the prion peptide PrP 106-126

Ferreiro, E.; Costa, R.; Marques, S.; Cardoso, S.M.; Oliveira, C.R.; Pereira, C.M.F., Journal of Neurochemistry. 766 - 776. 3. 104. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-38049162500&partnerID=MN8TOARS . 10.1111/j.1471-4159.2007.05048.x . Journal of Neurochemistry

Mitochondria and ubiquitin-proteasomal system interplay: Relevance to Parkinson's disease

Domingues, A.F.; Arduíno, D.M.; Esteves, A.R.; Swerdlow, R.H.; Oliveira, C.R.; Cardoso, S.M., Free Radical Biology and Medicine. 820 - 825. 6. 45. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-54949100005&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2008.06.007 . Free Radical Biology and Medicine

Mitochondrial dysfunction and caspase activation in rat cortical neurons treated with cocaine or amphetamine

Cunha-Oliveira, T.; Rego, A.C.; Cardoso, S.M.; Borges, F.; Swerdlow, R.H.; Macedo, T.; de Oliveira, C.R., Brain Research. 44 - 54. 1. 1089. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33646756208&partnerID=MN8TOARS . 10.1016/j.brainres.2006.03.061 . Brain Research

The key role of mitochondria in Alzheimer's disease

Moreira, P.I.; Cardoso, S.M.; Santos, M.S.; Oliveira, C.R., Journal of Alzheimer's Disease. 101 - 110. 2. 9. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33746066329&partnerID=MN8TOARS . Journal of Alzheimer's Disease

Protective effect of zinc on amyloid-ß 25-35 and 1-40 mediated toxicity

Cardoso, S.M.; Rego, A.C.; Pereira, C.; Oliveira, C.R., Neurotoxicity Research. 273 - 281. 4. 7. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-27744456147&partnerID=MN8TOARS . 10.1007/BF03033885 . Neurotoxicity Research

Alzheimer's disease-associated neurotoxic mechanisms and neuroprotective strategies

Pereira, C.; Agostinho, P.; Moreira, P.I.; Cardoso, S.M.; Oliveira, C.R., Current Drug Targets: CNS and Neurological Disorders. 383 - 403. 4. 4. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-23144463734&partnerID=MN8TOARS . 10.2174/1568007054546117 . Current Drug Targets: CNS and Neurological Disorders

Neurodegenerative pathways in Parkinson's disease: Therapeutic strategies

Cardoso, S.M.; Moreira, P.I.; Agostinho, P.; Pereira, C.; Oliveira, C.R.; Cardoso, S.; Moreira, P.; Oliveira, C., Current Drug Targets: CNS and Neurological Disorders. 405 - 419. 4. 4. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-23144431757&partnerID=MN8TOARS . 10.2174/1568007054546072 . Current Drug Targets: CNS and Neurological Disorders

The role of calcineurin in amyloid-ß-peptides-mediated cell death

Cardoso, S.M.; Oliveira, C.R., Brain Research. 1 - 7. 1-2. 1050. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-21544459062&partnerID=MN8TOARS . 10.1016/j.brainres.2005.04.078 . Brain Research

Alzheimers Disease-Associated Neurotoxic Mechanisms and Neuroprotective Strategies

Pereira, C.; Agostinho, P.; Moreira, P.; Cardoso, S.; Oliveira, C., Current Drug Target -CNS & Neurological Disorders. 383 - 403. 4. 4. 2005. http://dx.doi.org/10.2174/1568007054546117 . 10.2174/1568007054546117 . Current Drug Target -CNS & Neurological Disorders

Cell Degeneration Induced by Amyloid-ß Peptides: Implications for Alzheimer's Disease

Pereira, Cláudia; Ferreiro, Elisabete; Cardoso, Sandra Morais; de Oliveira, Catarina Resende, Journal of Molecular Neuroscience. 097 - 104. 1-2. 23. 2004. http://dx.doi.org/10.1385/jmn:23:1-2:097 . 10.1385/jmn:23:1-2:097 . Journal of Molecular Neuroscience

Cell degeneration induced by amyloid-ß peptides: Implications for Alzheimer's disease

Pereira, C.; Ferreiro, E.; Cardoso, S.M.; De Oliveira, C.R., Journal of Molecular Neuroscience. 97 - 104. 1-2. 23. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-4344669435&partnerID=MN8TOARS . Journal of Molecular Neuroscience

Cytochrome c oxidase is decreased in Alzheimer's disease platelets

Cardoso, S.M.; Proença, M.T.; Santos, S.; Santana, I.; Oliveira, C.R., Neurobiology of Aging. 105 - 110. 1. 25. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-0348111546&partnerID=MN8TOARS . 10.1016/S0197-4580(03)00033-2 . Neurobiology of Aging

Apoptotic cell death induced by hydrogen peroxide in NT2 parental and mitochondrial DNA depleted cells

Cardoso, S.M.; Rego, A.C.; Penacho, N.; Oliveira, C.R., Neurochemistry International. 693 - 698. 5. 45. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-3042590296&partnerID=MN8TOARS . 10.1016/j.neuint.2004.03.003 . Neurochemistry International

Mitochondria dysfunction of Alzheimer's disease cybrids enhances Aß toxicity

Cardoso, S.M.; Santana, I.; Swerdlow, R.H.; Oliveira, C.R., Journal of Neurochemistry. 1417 - 1426. 6. 89. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-3042513691&partnerID=MN8TOARS . 10.1111/j.1471-4159.2004.02438.x . Journal of Neurochemistry

Glutathione cycle impairment mediates Aß-induced cell toxicity

Cardoso, S.M.; Oliveira, C.R., Free Radical Research. 241 - 250. 3. 37. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037361527&partnerID=MN8TOARS . 10.1080/1071576021000041023 . Free Radical Research

Inhibition of NF-kB renders cells more vulnerable to apoptosis induced by amyloid ß peptides

Cardoso, S.M.; Oliveira, C.R., Free Radical Research. 967 - 973. 9. 37. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0141838915&partnerID=MN8TOARS . 10.1080/10715760310001595757 . Free Radical Research

Induction of cytocrome c-mediated apoptosis by amyloid beta 25-35 requires functional mitochondria

Sandra M Cardoso, Brain Research. 2002. Brain Research

Functional mitochondria are required for amyloid beta-mediated neurotoxicity.

Cardoso, S.M.; Santos, S.; Swerdlow, R.H.; Oliveira, C.R., The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 1439 - 1441. 8. 15. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035378322&partnerID=MN8TOARS . The FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Mitochondrial function is differentially affected upon oxidative stress

Cardoso, S.M.; Pereira, C.; Oliveira, C.R., Free Radical Biology and Medicine. 3 - 13. 1-2. 26. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0345222531&partnerID=MN8TOARS . 10.1016/S0891-5849(98)00205-6 . Free Radical Biology and Medicine

The protective effect of vitamin E, idebenone and reduced glutathione on free radical mediated injury in rat brain synaptosomes

Cardoso, S.M.; Pereira, C.; Oliveira, C.R., Biochemical and Biophysical Research Communications. 703 - 710. 3. 246. 1998. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032577242&partnerID=MN8TOARS . 10.1006/bbrc.1998.8563 . Biochemical and Biophysical Research Communications

Contribuição para o estudo do metabolismo da amiodarona: variação da concentração do iodo em diferentes orgãos dos ratinhos, após administração intraperitonial do fármaco.

Cardoso SM, Coimbra Médica. 15. 1994. Coimbra Médica

All projects

Show less

Information of exclusive responsibility of the researcher 21-11-2021 , from platform CIÊNCIAVITAE.

2022 - 2023

Microbiome-miRNAs axis in Parkinson’s disease: involvement of mitochondrial mediated inflammatory response

EXPL/MED-NEU/1515/2021

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2022 - 2025

Nontuberculous mycobacteria from drinking water: beyond the lung disease epidemic (Co-PI)

PTDC/BIA-MIC/0122/2021

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2021 -

STOPD - The Gut-Immune-Brain Axis in Parkinson disease

PTDC/MED-NEU/3644/2020

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2018/01 - 2018/12

O papel dos metabolitos microbianos na doença de Parkinson

Provided by PTCRIS: 83206

Principal investigator

Funders: Universidade de Coimbra Faculdade de Medicina

2018 - 2020

The ups and downs of cellular stress: the “MAM hypothesis” for Bipolar disorder pathophysiology

CENTRO-01-0145-FEDER-028214

Researcher

2018/09 - 2021/08

The role of quality control mechanisms in the loss of proteostasis in age-dependent neurodegenerative disorders.

FCT-C490959332-00082704/2018

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2017 - 2020

Healthy Aging

CENTRO-01-0145-FEDER-000012

Researcher

2017/09 - 2020/08

The toxinogenic gut microbiome in sporadic Parkinson’s Disease: a quest for new “antiPDbiotics”.

Provided by PTCRIS: 57310

Principal investigator

Funders: Santa Casa da Misericórdia de Lisboa

2016/09 - 2017/08

AntiPDbiotics: The impairment of neuronal metabolism by gut microbiome effectors

FMUC-BST-2016-221

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Universidade de Coimbra Faculdade de Medicina

2014/01 - 2014/12

Validate tau acetylation as an AD biomarker

GAI-FMUC

Principal investigator

2014/01 - 2014/12

Produção e comercialização global de compostos microbianos essenciais para investigação.

Mais Centro/CCDRC/QREN

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

2013 - 2015

New strategies to manage brain diseases

QREN

Researcher

2010/04 - 2013/03

The pathological interaction between diabetes and Alzheimer's disease: exploring the role of brain endothelial mitochondria and uncoupling proteins

Provided by PTCRIS: 103325

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia, I.P.

2010/02 - 2013/05

Mitochondrial-dependent impairment of intracellular trafficking in Parkinson's disease

Provided by PTCRIS: 102710

Principal investigator

Funders: Fundação para a Ciência e a Tecnologia, I.P.

2009 - 2011

Early Diagnosis of Alzheimer’s Disease: evaluation of recent classification criteria and proposal of new diagnostic tools.

PIC/IC/83206/2007

Researcher

2008 - 2009

A associação entre a mitocôndria e o sistema ubiquitina/proteosoma no âmbito da doença de Parkinson.

GAI 15/08 FMUC

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Universidade de Coimbra Faculdade de Medicina

2008 - 2009

O papel da disfunção mitocondrial na alteração do citoesqueleto: relevância para a Doença de Parkinson

GAI 07/08 FMUC

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Universidade de Coimbra Faculdade de Medicina

2007 - 2013

NEUROMED

SOE4/P1/E831

Researcher

2005 - 2006

From mitochondrial dysfunction to protein aggregation in Parkinson’s disease

GAI 03/04 FMUC

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Universidade de Coimbra Faculdade de Medicina

We use cookies to improve your visit to our website.