Sandra Sofia Mimoso Pinhanços

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PhD Student

Publications

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Information about journal articles, updated at 05-12-2021, from platform CIÊNCIAVITAE.

Irinotecan Induces Disease Remission in Xenograft Mouse Models of Pediatric MLL-Rearranged Acute Lymphoblastic Leukemia

Mark Kerstjens; Patricia Garrido Castro; Sandra S. Pinhanços; Pauline Schneider; Priscilla Wander; Rob Pieters; Ronald W. Stam, Biomedicines. 2021. https://doi.org/10.3390/biomedicines9070711 . 10.3390/biomedicines9070711 . Biomedicines

High-throughput drug screening reveals Pyrvinium pamoate as effective candidate against pediatric MLL-rearranged acute myeloid leukemia

Priscilla Wander; Susan T.C.J.M. Arentsen-Peters; Sandra S. Pinhan¿os; Bianca Koopmans; M.Emmy M. Dolman; Rijndert Ariese; Frank L. Bos; et al, Translational Oncology. 2021. https://doi.org/10.1016/j.tranon.2021.101048 . 10.1016/j.tranon.2021.101048 . Translational Oncology

Decitabine mildly attenuates MLL -rearranged acute lymphoblastic leukemia in vivo, and represents a poor chemo-sensitizer

Pinhanços, eJHaem. 2020. http://dx.doi.org/10.1002/jha2.81 . 10.1002/jha2.81 . eJHaem

Preclinical efficacy of gemcitabine in MLL-rearranged infant acute lymphoblastic leukemia

Pinhanços, Leukemia. 2020. http://dx.doi.org/10.1038/s41375-020-0895-9 . 10.1038/s41375-020-0895-9 . Leukemia

Trametinib inhibits RAS-mutant MLL-rearranged acute lymphoblastic leukemia at specific niche sites and reduces ERK phosphorylation in vivo.

Kerstjens M; Pinhancos SS; Garrido Castro P; Schneider P; Wander P; Pieters R; Stam RW, Haematologica. 2018. http://europepmc.org/abstract/med/29419436 . 10.3324/haematol.2017.174060 . Haematologica

The HDAC inhibitor panobinostat (LBH589) exerts in vivo anti-leukaemic activity against MLL-rearranged acute lymphoblastic leukaemia and involves the RNF20/RNF40/WAC-H2B ubiquitination axis.

Garrido Castro P; van Roon EHJ; Pinhanços SS; Trentin L; Schneider P; Kerstjens M; Te Kronnie G; et al, Leukemia. 2018. http://europepmc.org/abstract/med/28690313 . 10.1038/leu.2017.216 . Leukemia

MEK inhibition is a promising therapeutic strategy for MLL-rearranged infant acute lymphoblastic leukemia patients carrying RAS mutations.

Kerstjens M; Driessen EM; Willekes M; Pinhanços SS; Schneider P; Pieters R; Stam RW, Oncotarget. 2017. http://europepmc.org/abstract/med/27588400 . 10.18632/oncotarget.11730 . Oncotarget

Versican expression is an adverse prognostic factor in MLL-rearranged infant acute lymphoblastic leukaemia.

Driessen EM; Pinhanços SS; Schneider P; de Lorenzo P; Valsecchi MG; Pieters R; Stam RW, European journal of cancer (Oxford, England : 1990). 2016. http://europepmc.org/abstract/med/26901613 . 10.1016/j.ejca.2015.12.031 . European journal of cancer (Oxford, England : 1990)

Chemical genomic screening identifies LY294002 as a modulator of glucocorticoid resistance in MLL-rearranged infant ALL.

Spijkers-Hagelstein JA; Pinhanços SS; Schneider P; Pieters R; Stam RW, Leukemia. 2014. http://europepmc.org/abstract/med/23958920 . 10.1038/leu.2013.245 . Leukemia

Glucocorticoid sensitisation in Mixed Lineage Leukaemia-rearranged acute lymphoblastic leukaemia by the pan-BCL-2 family inhibitors gossypol and AT-101.

Spijkers-Hagelstein JA; Schneider P; Pinhanços SM; Garrido Castro P; Pieters R; Stam RW, European journal of cancer (Oxford, England : 1990). 2014. http://europepmc.org/abstract/med/24703900 . 10.1016/j.ejca.2014.03.011 . European journal of cancer (Oxford, England : 1990)

AMP-activated protein kinase activation by 5-aminoimidazole-4-carbox-amide-1-ß-D-ribofuranoside (AICAR) reduces lipoteichoic acid-induced lung inflammation.

Hoogendijk AJ; Pinhanços SS; van der Poll T; Wieland CW, The Journal of biological chemistry. 2013. http://europepmc.org/abstract/med/23322781 . 10.1074/jbc.m112.413138 . The Journal of biological chemistry

Src kinase-induced phosphorylation of annexin A2 mediates glucocorticoid resistance in MLL-rearranged infant acute lymphoblastic leukemia.

Spijkers-Hagelstein JA; Mimoso Pinhanços S; Schneider P; Pieters R; Stam RW, Leukemia. 2013. http://europepmc.org/abstract/med/23334362 . 10.1038/leu.2012.372 . Leukemia

Intrapulmonary administration of a p38 mitogen activated protein kinase inhibitor partially prevents pulmonary inflammation.

Hoogendijk AJ; Pinhanços SS; van der Poll T; Wieland CW, Immunobiology. 2013. http://europepmc.org/abstract/med/22727776 . 10.1016/j.imbio.2012.05.027 . Immunobiology

Serum homocysteine: interplay with other circulating and genetic factors in association to Alzheimer's type dementia.

Cascalheira JF; João SS; Pinhanços SS; Castro R; Palmeira M; Almeida S; Faria MC; Domingues FC, Clinical biochemistry. 2009. http://europepmc.org/abstract/med/19232336 . 10.1016/j.clinbiochem.2009.02.006 . Clinical biochemistry

All projects

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Information of exclusive responsibility of the researcher 05-12-2021 , from platform CIÊNCIAVITAE.

2020/03/01 -

Extracellular Vesicles in Diabetes

SFRH/BD/144119/2019

PhD Student Fellow

Center for Neurosciences and Cell Biology, University of Coimbra

Funders: Associação para a Inovação e Desenvolvimento da FCT

2018/10/08 -

Towards personalized beta-cell mass imaging in type 2 Diabetes

95105008

Technical development

Biocant Associação de Transferência de Tecnologia

Funders: ZonMw

2016 - 2018

High Throughput of epigenetic drug screening in high risk leukemias

-

Technical development

Princess Maxima Center, Center for Pediatric Oncology

Funders: Stichting Kinderen Kankervrij (KiKa)

2012 - 2016

Role of epigenetics in MLL rearranged infant ALL

-

Technical development

Erasmus MC

2012 - 2016

Role of Bone Marrow niche Microenvironment in MLL-rearranged ALL using in vivo xenotransplantations models

KIKA.Project89

Technical development

Erasmus MC

Funders: Stichting Kinderen Kankervrij (KiKa)

2010 - 2010

The potency of AMPK activation by AICAR to reduce inflammation in vitro and in vivo in a model of LTA-induced lung injury

-

Other

Amsterdam Medical Center

2010 - 2010

Impact of p38 mitogen activated protein kinase inhibitor in pulmonary inflammation

-

Other

Amsterdam Medical Center

2010 - 2010

The potency of AMPK activation by AICAR to reduce inflammation in vitro and in vivo in a model of LTA-induced lung injury

-

Other

Amsterdam Medical Center

2007 - 2008

Detection of Human Bocavirus in children with Respiratory Infection

Master project

Other

Universidade da Beira Interior Centro de Investigação em Ciências da Saúde

2006 - 2007

Serum homocysteine: interplay with other circulating and genetic factors in association to Alzheimer's type dementia

Projecto de Licenciatura

Other

Universidade da Beira Interior Centro de Investigação em Ciências da Saúde

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