Metabolism, Aging and Disease

Endoplasmic Reticulum (ER) Stress Response and ER-Mitochondria Axis

Endoplasmic reticulum stress

Mitochondrial dysfunction

Mitochondria-associated membranes

Mental illness

Neurodegenerative diseases


Research lines

Role of ER stress in NLRP3 inflammasome activation

Alzheimer’s disease-associated lipid and metabolic alterations: role of Mitochondria-Associated Membranes (MAM)

Morphological and functional changes in Mitochondria-Associated Membranes in bipolar disorder (BD) and schizophrenia (SZ)

Bioactivity of extracts from natural resources, namely anti-inflammatory, anti-oxidant, neuroprotective and anti-senescent effects

Overview

Our mission is to investigate the molecular basis of neuropsychiatric disorders associated with metabolic and inflammatory alterations, namely age-related neurodegenerative disorders, such as Alzheimer’s disease, and mood disorders, such as bipolar disorder and schizophrenia, in order to identify potential applications in the diagnosis, prognosis and therapy. We use several disease models like cell lines and primary cell cultures and also sub-cellular fractions, control- versus patient-derived cells and transgenic mice, together with multiple experimental approaches including biochemistry, molecular and cellular biology, and animal behavior analysis. Our group focus on the disease-associated deregulation of endoplasmic reticulum (ER) and mitochondria stress responses and its implications in proteostasis, lipid and energetic metabolism, calcium homeostasis and inflammation, and we are also interested in understanding how disturbances of ER-mitochondria axis trigger pathological stress responses. Our studies can contribute to the development of novel therapies for the above diseases promoting human health and well-being, particularly multifaceted disease-modifying strategies based on bioactive natural resources.

Featured Articles

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Information about journal articles, updated at 28-11-2021, from platform CIÊNCIAVITAE.

APOE ¿4-TOMM40L Haplotype Increases the Risk of Mild Cognitive Impairment Conversion to Alzheimer's Disease

Cardoso, R.; Lemos, C.; Oliveiros, B.; Almeida, M.R.; Baldeiras, I.; Pereira, C.F.; Santos, A.; et al, 2020. Journal of Alzheimer's Disease. 587 - 601. 2. 78. 2020. http://www.scopus.com/inward/record.url?eid=2-s2.0-85096134035&partnerID=MN8TOARS . 10.3233/JAD-200556 . Journal of Alzheimer's Disease

Brain atrophy and physical disability in primary progressive multiple sclerosis: A volumetric study

Galego, Orlando; Gouveia, Ana; Batista, Sónia; Moura, Cristina; Machado, Egídio, 2015. The Neuroradiology Journal. 354 - 358. 3. 28. 2015. 10.1177/1971400915594984 . published The Neuroradiology Journal

Early intervention and no evidence of disease activity (NEDA): Are we ready to change our practices?

Batista, Sónia; de Sousa, Lívia, 2016. Sinapse. 36 - 40. 2. 16. 2016. published Sinapse

Evaluation of simulation or effort insufficient with the Rey 15-Item Memory Test (IMT-15): Validation studies in groups of older adults | Avaliação da simulação ou esforço insuficiente com o Rey 15-Item Memory Test (15-IMT): Estudos de validação em grupos de adultos idosos

Simões, M.; Sousa, L.; Duarte, P.; Firmino, H.; Pinho, M.S.; Gaspar, N.; Pires, L.; et al, 2010. Analise Psicologica. 209 - 226. 1. 28. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875022344&partnerID=MN8TOARS . Analise Psicologica


Publications

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Information about journal articles, updated at 28-11-2021, from platform CIÊNCIAVITAE.

Mitochondrial Alterations in Fibroblasts of Early Stage Bipolar Disorder Patients

Ana P. Marques; Rosa Resende; Diana F. Silva; Mariana Batista; Daniela Pereira; Brigite Wildenberg; Sofia Morais; et al, 2021. Biomedicines. 2021. https://www.mdpi.com/2227-9059/9/5/522 . 10.3390/biomedicines9050522 . Biomedicines

Structural and Functional Alterations in Mitochondria-Associated Membranes (MAMs) and in Mitochondria Activate Stress Response Mechanisms in an In Vitro Model of Alzheimer’s Disease

Tânia Fernandes; Rosa Resende; Diana F. Silva; Ana P. Marques; Armanda E. Santos; Sandra M. Cardoso; M. Rosário Domingues; Paula I. Moreira; Cláudia F. Pereira, 2021. Biomedicines. 881 - 881. 8. 9. 2021. https://doi.org/10.3390/biomedicines9080881 . 10.3390/biomedicines9080881 . Biomedicines

Therapies for Alzheimer’s disease: a metabolic perspective

Domingues, Raquel; Pereira, Claúdia; Cruz, Maria Teresa; Silva, Ana, 2021. Molecular Genetics and Metabolism. 21. S1096-71. 2021. http://dx.doi.org/10.1016/j.ymgme.2021.01.011 . 10.1016/j.ymgme.2021.01.011 . published Molecular Genetics and Metabolism

Inflammation in Bipolar Disorder (BD): Identification of new therapeutic targets

Pereira, Ana Catarina; Oliveira, Joana; Silva, Sónia; Madeira, Nuno; Pereira, Cláudia M.F.; Cruz, Maria T., 2021. Pharmacological Research. 163. 2021. http://dx.doi.org/10.1016/j.phrs.2020.105325 . 10.1016/j.phrs.2020.105325 . published Pharmacological Research

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Pereira, Cláudia, 2021. Autophagy. 1 - 382. 8. 2021. published Autophagy

New BACE1 Chimeric Peptide Inhibitors Selectively Prevent AßPPß Cleavage Decreasing Amyloid-ß Production and Accumulation in Alzheimer’s Disease Models

Resende, Rosa; Ferreira-Marques, Marisa; Moreira, Patrícia; Coimbra, Judite R.M.; Baptista, Salete J.; Isidoro, Ciro; Salvador, Jorge A.R.; et al, 2020. Journal of Alzheimer's Disease. 1317 - 1337. 6. 70. 2020. http://dx.doi.org/10.3233/jad-200381 . 10.3233/jad-200381 . published Journal of Alzheimer's Disease

Anti-inflammatory potential of Portuguese thermal waters

Silva, A.; Oliveira, A. S.; Vaz, C. V.; Correia, S.; Ferreira, R.; Breitenfeld, L.; Martinez-de-Oliveira, J.; et al, 2020. Scientific Reports. 1. 10. 2020. http://dx.doi.org/10.1038/s41598-020-79394-9 . 10.1038/s41598-020-79394-9 . published Scientific Reports

Calcium Modulation, Anti-Oxidant and Anti-Inflammatory Effect of Skin Allergens Targeting the Nrf2 Signaling Pathway in Alzheimer’s Disease Cellular Models

Silva, Ana; Pereira, Marta; Carrascal, Mylène A.; Brites, Gonçalo; Neves, Bruno; Moreira, Patrícia; Resende, Rosa; et al, 2020. International Journal of Molecular Sciences. 20. 21. 2020. http://dx.doi.org/10.3390/ijms21207791 . 10.3390/ijms21207791 . International Journal of Molecular Sciences

APOE ¿4-TOMM40L Haplotype Increases the Risk of Mild Cognitive Impairment Conversion to Alzheimer’s Disease

Cardoso, Remy; Lemos, Carolina; Oliveiros, Bárbara; Almeida, Maria Rosário; Baldeiras, Inês; Pereira, Cláudia Fragão; Santos, Ana; et al, 2020. Journal of Alzheimer's Disease. 587 - 601. 2. 78. 2020. http://dx.doi.org/10.3233/jad-200556 . 10.3233/jad-200556 . published Journal of Alzheimer's Disease

In vitro evaluation of potential benefits of a silica-rich thermal water (Monfortinho Thermal Water) in hyperkeratotic skin conditions

Ana Sofia Oliveira; Cátia Vicente Vaz; Ana Silva; Sara Correia; Raquel Ferreira; Luiza Breitenfeld; José Martinez-de-Oliveira; et al, 2020. International Journal of Biometeorology. 2020. https://doi.org/10.1007/s00484-020-01986-x . 10.1007/s00484-020-01986-x . International Journal of Biometeorology

Characterization and Cytotoxicity Assessment of the Lipophilic Fractions of Different Morphological Parts of Acacia dealbata

Cátia S. D. Oliveira; Patrícia Moreira; Judite Resende; Maria T. Cruz; Cláudia M. F. Pereira; Artur M. S. Silva; Sónia A. O. Santos; Armando J. D. Silvestre, 2020. International Journal of Molecular Sciences. 1814 - 1830. 5. 21. 2020. https://doi.org/10.3390/ijms21051814 . 10.3390/ijms21051814 . International Journal of Molecular Sciences

Mitochondria, endoplasmic reticulum and innate immune dysfunction in mood disorders: Do Mitochondria-Associated Membranes (MAMs) play a role?

R. Resende; T. Fernandes; A.C. Pereira; J. De Pascale; A.P. Marques; P. Oliveira; S. Morais; et al, 2020. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 165752 - 165752. 6. 1866. 2020. https://doi.org/10.1016/j.bbadis.2020.165752 . 10.1016/j.bbadis.2020.165752 . published Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Calcium Signaling in Aging and Neurodegenerative Diseases 2019

Luísa Cortes; João Malva; Ana Cristina Rego; Cláudia F. Pereira, 2020. International Journal of Molecular Sciences. 1125 - 1125. 3. 21. 2020. https://doi.org/10.3390/ijms21031125 . 10.3390/ijms21031125 . International Journal of Molecular Sciences

Is Alzheimer’s disease an inflammasomopathy?

Pereira, Claudia F.; Santos, Armanda E.; Moreira, Paula I.; Pereira, Ana Catarina; Sousa, Fabio J.; Cardoso, Sandra M.; Cruz, M. Teresa, 2019. Ageing Research Reviews. 56. 2019. http://dx.doi.org/10.1016/j.arr.2019.100966 . 10.1016/j.arr.2019.100966 . Ageing Research Reviews

The Eighth ECS Workshop on “Calcium Signaling in Aging and Neurodegenerative Diseases”

Jan Parys; C Pereira; Carlos Villalobos, 2019. International Journal of Molecular Sciences. 2019. https://www.mdpi.com/1422-0067/20/24/6263 . 10.3390/ijms20246263 . International Journal of Molecular Sciences

Chemical signature and antimicrobial activity of Central Portuguese Natural Mineral Waters against selected skin pathogens

Oliveira, Ana Sofia; Vaz, Cátia Vicente; Silva, Ana; Ferreira, Sandra Saraiva; Correia, Sara; Ferreira, Raquel; Breitenfeld, Luiza; et al, 2019. Environmental Geochemistry and Health. 2019. http://dx.doi.org/10.1007/s10653-019-00473-6 . 10.1007/s10653-019-00473-6 . published Environmental Geochemistry and Health

When, where and how: mitochondrial multifaceted dysfunction in Alzheimer's disease

Oliveira, C. R.; Pereira, C.; Rego, A. C.; Moreira, P. I.; Cardoso, S., 2017. European Journal of Clinical Investigation. 24 - 25. 47. 2017. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000412099900035&KeyUID=WOS:000412099900035 . European Journal of Clinical Investigation

Phosphatase 2A Inhibition Affects Endoplasmic Reticulum and Mitochondria Homeostasis Via Cytoskeletal Alterations in Brain Endothelial Cells

Placido, Ana I.; Pereira, Claudia M. F.; Correira, Sonia C.; Carvalho, Cristina; Oliveira, Catarina R.; Moreira, Paula I., 2017. Molecular Neurobiology. 154 - 168. 1. 54. 2017. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000392133900014&KeyUID=WOS:000392133900014 . 10.1007/s12035-015-9640-1 . Molecular Neurobiology

Enhanced Amyloidogenic Processing of Amyloid Precursor Protein and Cell Death Under Prolonged Endoplasmic Reticulum Stress in Brain Endothelial Cells

Placido, Ana I.; Oliveira, Catarina R.; Moreira, Paula I.; Pereira, Claudia Maria F., 2015. Molecular Neurobiology. 571 - 590. 2. 51. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000351311800012&KeyUID=WOS:000351311800012 . 10.1007/s12035-014-8819-1 . Molecular Neurobiology

Daucus carota subsp gummifer essential oil as a natural source of antifungal and anti-inflammatory drugs

Valente, J.; Zuzarte, M.; Resende, R.; Goncalves, M. J.; Cavaleiro, C.; Pereira, C. F.; Cruz, M. T.; Salgueiro, L., 2015. Industrial Crops and Products. 361 - 366. 65. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000349430000046&KeyUID=WOS:000349430000046 . 10.1016/j.indcrop.2014.11.014 . Industrial Crops and Products

Bioactivity and safety profile of Daucus carota subsp maximus essential oil

Valente, J.; Resende, R.; Zuzarte, M.; Goncalves, M. J.; Lopes, M. C.; Cavaleiro, C.; Pereira, C.; Salgueiro, L.; Cruz, M. T., 2015. Industrial Crops and Products. 218 - 224. 77. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000366065200028&KeyUID=WOS:000366065200028 . 10.1016/j.indcrop.2015.08.037 . Industrial Crops and Products

Amyloid-Beta Disrupts Calcium and Redox Homeostasis in Brain Endothelial Cells

Fonseca, Ana Catarina R. G.; Moreira, Paula I.; Oliveira, Catarina R.; Cardoso, Sandra M.; Pinton, Paolo; Pereira, Claudia F., 2015. Molecular Neurobiology. 610 - 622. 2. 51. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000351311800015&KeyUID=WOS:000351311800015 . 10.1007/s12035-014-8740-7 . Molecular Neurobiology

New promising peptides to inhibit BACE1: evaluation of compound efficiency in cellular and mouse models of Alzheimer’s disease

Resende, Rosa; Pereira, Cláudia; Dinis, Teresa; Santos, Armanda E.; Ferreira-Marques, Marisa, 2015. Sinapse. 2015. http://www.geecd.org/images/GEECDFiles/29a_Reuniao_do_GEECD_ResumosSinapse.pdf . published Sinapse

A beta and NMDAR activation cause mitochondrial dysfunction involving ER calcium release

Ferreira, Ildete Luisa; Ferreiro, Elisabete; Schmidt, Jeannette; Cardoso, Joao M.; Pereira, Claudia M. F.; Carvalho, Ana Luisa; Oliveira, Catarina R.; Cristina Rego, A., 2015. Neurobiology of Aging. 680 - 692. 2. 36. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000352454400014&KeyUID=WOS:000352454400014 . 10.1016/j.neurobiolaging.2014.09.006 . Neurobiology of Aging

BRI2 ectodomain affects A beta(42) fibrillation and tau truncation in human neuroblastoma cells

Del Campo, M.; Oliveira, C. R.; Scheper, W.; Zwart, R.; Korth, C.; Mueller-Schiffmann, A.; Kostallas, G.; et al, 2015. Cellular and Molecular Life Sciences. 1599 - 1611. 8. 72. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000351456000012&KeyUID=WOS:000351456000012 . 10.1007/s00018-014-1769-y . Cellular and Molecular Life Sciences

Oxidative stress involving changes in Nrf2 and ER stress in early stages of Alzheimer's disease

Mota, Sandra I.; Costa, Rui O.; Ferreira, Ildete L.; Santana, Isabel; Caldeira, Gladys L.; Padovano, Carmela; Fonseca, Ana C.; et al, 2015. Biochimica Et Biophysica Acta-Molecular Basis of Disease. 1428 - 1441. 7. 1852. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000355715200021&KeyUID=WOS:000355715200021 . 10.1016/j.bbadis.2015.03.015 . Biochimica Et Biophysica Acta-Molecular Basis of Disease

Modulation of Endoplasmic Reticulum Stress: An Opportunity to Prevent Neurodegeneration?

Placido, Ana I.; Pereira, Claudia M. F.; Duarte, Ana I.; Candeias, Emanuel; Correia, Sonia C.; Carvalho, Cristina; Cardoso, Susana; Oliveira, Catarina R.; Moreira, Paula I., 2015. Cns & Neurological Disorders-Drug Targets. 518 - 533. 4. 14. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000354179100012&KeyUID=WOS:000354179100012 . 10.2174/1871527314666150429112353 . Cns & Neurological Disorders-Drug Targets

Alzheimer's Disease-Related Misfolded Proteins and Dysfunctional Organelles on Autophagy Menu

Correia, Sonia C.; Resende, Rosa; Moreira, Paula I.; Pereira, Claudia M., 2015. DNA and Cell Biology. 261 - 273. 4. 34. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000352342300005&KeyUID=WOS:000352342300005 . 10.1089/dna.2014.2757 . DNA and Cell Biology

Protective Effect of Leptin and Ghrelin against Toxicity Induced by Amyloid- beta Oligomers in a Hypothalamic cell Line

Gomes, S.; Martins, I.; Fonseca, A. C. R. G.; Oliveira, C. R.; Resende, R.; Pereira, C. M. F., 2014. Journal of Neuroendocrinology. 176 - 185. 3. 26. 2014. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000333329700004&KeyUID=WOS:000333329700004 . 10.1111/jne.12138 . Journal of Neuroendocrinology

MISFOLDED BRI2 ECTODOMAIN ACTIVATES CRITICAL PATHOLOGICAL PATHWAYS INVOLVED IN EARLY STAGES OF ALZHEIMER'S DISEASE

Campo Milan, Marta Del; Pereira, Cláudia; Scheper, W.; Zwart, R.; Hoozemans, Jeroen; Oliveira, Catarina; Teunissen, Charlotte, 2014. Alzheimer's & Dementia. 4. 10. 2014. http://dx.doi.org/10.1016/j.jalz.2014.05.323 . 10.1016/j.jalz.2014.05.323 . published Alzheimer's & Dementia

Antifungal and anti-inflammatory claims for wild carrot essential oil

Valente, J.; Resende, R.; Zuzarte, M.; Goncalves, M. J.; Lopes, M. C.; Cavaleiro, C.; Pereira, C.; Salgueiro, L.; Cruz, M. T., 2014. Planta Medica. 1454 - 1454. 16. 80. 2014. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000345550400318&KeyUID=WOS:000345550400318 . Planta Medica

Loss of proteostasis induced by amyloid beta peptide in brain endothelial cells

Fonseca, Ana Catarina; Oliveira, Catarina R.; Pereira, Claudia F.; Cardoso, Sandra M., 2014. Biochimica Et Biophysica Acta-Molecular Cell Research. 1150 - 1161. 6. 1843. 2014. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000335627900010&KeyUID=WOS:000335627900010 . 10.1016/j.bbamcr.2014.02.016 . Biochimica Et Biophysica Acta-Molecular Cell Research

The role of endoplasmic reticulum in amyloid precursor protein processing and trafficking: Implications for Alzheimer's disease

Placido, A. I.; Pereira, C. M. F.; Duarte, A. I.; Candeias, E.; Correia, S. C.; Santos, R. X.; Carvalho, C.; et al, 2014. Biochimica Et Biophysica Acta-Molecular Basis of Disease. 1444 - 1453. 9. 1842. 2014. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000340975400016&KeyUID=WOS:000340975400016 . 10.1016/j.bbadis.2014.05.003 . Biochimica Et Biophysica Acta-Molecular Basis of Disease

Inhibition of mitochondrial cytochrome c oxidase potentiates Aß-induced ER stress and cell death in cortical neurons

Costa, R.O.; Ferreiro, E.; Oliveira, C.R.; Pereira, C.M.F., 2013. Molecular and Cellular Neuroscience. 1 - 8. 52. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870349573&partnerID=MN8TOARS . 10.1016/j.mcn.2012.09.005 . Molecular and Cellular Neuroscience

Activation of the endoplasmic reticulum stress response by the amyloid-beta 1-40 peptide in brain endothelial cells

Fonseca, Ana Catarina R. G.; Ferreiro, Elisabete; Oliveira, Catarina R.; Cardoso, Sandra M.; Pereira, Claudia F., 2013. Biochimica Et Biophysica Acta-Molecular Basis of Disease. 2191 - 2203. 12. 1832. 2013. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000327567600030&KeyUID=WOS:000327567600030 . 10.1016/j.bbadis.2013.08.007 . Biochimica Et Biophysica Acta-Molecular Basis of Disease

Effect of a-Synuclein on amyloid ß-Induced toxicity: Relevance to lewy body variant of alzheimer disease

Resende, R.; Marques, S.C.F.; Ferreiro, E.; Simões, I.; Oliveira, C.R.; Pereira, C.M.F., 2013. Neurochemical Research. 797 - 806. 4. 38. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876164250&partnerID=MN8TOARS . 10.1007/s11064-013-0982-7 . Neurochemical Research

Leptin and ghrelin prevent hippocampal dysfunction induced by Aß oligomers

Martins, I.; Gomes, S.; Costa, R.O.; Otvos, L.; Oliveira, C.R.; Resende, R.; Pereira, C.M.F., 2013. Neuroscience. 41 - 51. 241. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876430099&partnerID=MN8TOARS . 10.1016/j.neuroscience.2013.02.062 . Neuroscience

Amyloid-Beta Peptide 1-42 Causes Microtubule Deregulation through N-methyl-D-aspartate Receptors in Mature Hippocampal Cultures

Mota, Sandra I.; Ferreira, Ildete L.; Pereira, Claudia; Oliveira, Catarina R.; Cristina Rego, A., 2012. Current Alzheimer Research. 844 - 856. 7. 9. 2012. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000308863600009&KeyUID=WOS:000308863600009 . Current Alzheimer Research

Mitochondrial- and endoplasmic reticulum-associated oxidative stress in Alzheimer's disease: from pathogenesis to biomarkers.

Ferreiro E; Baldeiras I; Ferreira IL; Costa RO; Rego AC; Pereira CF; Oliveira CR, 2012. 2012. http://europepmc.org/abstract/med/22701485 . 10.1155/2012/735206 .

Amyloid ß-induced ER stress is enhanced under mitochondrial dysfunction conditions

Costa, R.O.; Ferreiro, E.; Martins, I.; Santana, I.; Cardoso, S.M.; Oliveira, C.R.; Pereira, C.M.F., 2012. Neurobiology of Aging. 4. 33. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856951448&partnerID=MN8TOARS . 10.1016/j.neurobiolaging.2011.04.011 . Neurobiology of Aging

Endoplasmic reticulum stress: A new playER in tauopathies

Ferreiro, E.; Pereira, C.M.F., 2012. Journal of Pathology. 687 - 692. 5. 226. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857998807&partnerID=MN8TOARS . 10.1002/path.3977 . Journal of Pathology

Endoplasmic reticulum stress occurs downstream of GluN2B subunit of N-methyl-d-aspartate receptor in mature hippocampal cultures treated with amyloid-ß oligomers

Costa, R.O.; Lacor, P.N.; Ferreira, I.L.; Resende, R.; Auberson, Y.P.; Klein, W.L.; Oliveira, C.R.; Rego, A.C.; Pereira, C.M.F., 2012. Aging Cell. 823 - 833. 5. 11. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866452758&partnerID=MN8TOARS . 10.1111/j.1474-9726.2012.00848.x . Aging Cell

Amyloid-beta peptide 1-42 causes microtubule deregulation through N-methyl-D-aspartate receptors in mature hippocampal cultures

Mota, S.I.; Ferreira, I.L.; Pereira, C.; Oliveira, C.R.; Rego, A.C., 2012. Current Alzheimer Research. 844 - 856. 7. 9. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866468436&partnerID=MN8TOARS . 10.2174/156720512802455322 . Current Alzheimer Research

Epigenetic regulation of BACE1 in Alzheimer's disease patients and in transgenic mice

Marques, S.C.F.; Lemos, R.; Ferreiro, E.; Martins, M.; de Mendonça, A.; Santana, I.; Outeiro, T.F.; Pereira, C.M.F., 2012. Neuroscience. 256 - 266. 220. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864770859&partnerID=MN8TOARS . 10.1016/j.neuroscience.2012.06.029 . Neuroscience

Epigenetics in neurodegeneration: A new layer of complexity

Marques, S.C.F.; Oliveira, C.R.; Pereira, C.M.F.; Outeiro, T.F., 2011. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 348 - 355. 2. 35. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952900959&partnerID=MN8TOARS . 10.1016/j.pnpbp.2010.08.008 . Progress in Neuro-Psychopharmacology and Biological Psychiatry

Injury markers in peripheral blood mononuclear cells from mild cognitive impairment and Alzheimer’s disease patients

Ferreira, Ildete Luisa; Mota, Sandra Isabel; Costa, Rui Miguel Oliveira da; Padovano, C; Fonseca, Ana Catarina Ribeiro da Graça; Letra, Liliana; Resende de Oliveira, Catarina; et al, 2011. Journal of Neurodegenerative Diseases. Supplement. 1. 2011. published Journal of Neurodegenerative Diseases

Mitochondria control NMDA receptor-dependent calcium rise evoked by amyloid-ß 1-42 oligomers in rat cortical neurons

Ferreiro, Elisabete; Ferreira, Ildete Luisa; Cardoso, Joao M.; Pereira, Cláudia; Resende de Oliveira, Catarina; Rego, Ana Cristina Carvalho, 2011. Alzheimer's & Dementia: Journal of Alzheimer's Association. 4. 7. 2011. published Alzheimer's & Dementia: Journal of Alzheimer's Association

Amyloid-beta oligomers cause microtubule deregulation through NMDA receptors in mature hippocampal neurons

Mota, Sandra Isabel; Ferreira, Ildete Luisa; Resende de Oliveira, Catarina; Pereira, Cláudia; Rego, Ana Cristina Carvalho, 2011. Journal of Neurodegenerative Disorders. Supplement. 1. 2011. published Journal of Neurodegenerative Disorders

Epigenetics and Neurodegeneration: A Connection Overlooked

Marques, Sueli C. F.; Pereira, Claudia M. F.; Outeiro, Tiago F., 2010. Epigenetics: Mechanism, Functions and Human Effects. 241 - 252. 2010. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000278550400010&KeyUID=WOS:000278550400010 . Epigenetics: Mechanism, Functions and Human Effects

Multiple Defects in Energy Metabolism in Alzheimer's Disease

Ferreira, I. L.; Resende, R.; Ferreiro, E.; Rego, A. C.; Pereira, C. F., 2010. Current Drug Targets. 1193 - 1206. 10. 11. 2010. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000285183900002&KeyUID=WOS:000285183900002 . Current Drug Targets

ER stress-mediated apoptotic pathway induced by aß peptide requires the presence of functional mitochondria

Costa, R.O.; Ferreiro, E.; Cardoso, S.M.; Oliveira, C.R.; Pereira, C.M.F., 2010. Journal of Alzheimer's Disease. 625 - 636. 2. 20. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954516455&partnerID=MN8TOARS . 10.3233/JAD-2010-091369 . Journal of Alzheimer's Disease

ROLE OF GLYCOGEN SYNTHASE KINASE-3B ON TAU PHOSPHORYLATION IN ALZHEIMER'S DISEASE

Resende, Rosa; Oliveira, Catarina Resende; Pereira, Claudia M. F., 2010. Advances in Medicine and Biology, Vol 2. 197 - 210. 2. 2010. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000278696200007&KeyUID=WOS:000278696200007 . Advances in Medicine and Biology, Vol 2

Alzheimer's disease: The quest to understand complexity

Marques, S.C.F.; Oliveira, C.R.; Outeiro, T.F.; Pereira, C.M.F., 2010. Journal of Alzheimer's Disease. 373 - 383. 2. 21. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957352488&partnerID=MN8TOARS . 10.3233/JAD-2010-100303 . Journal of Alzheimer's Disease

Cholesterol and statins in Alzheimer's disease: Current controversies

Fonseca, A.C.R.G.; Resende, R.; Oliveira, C.R.; Pereira, C.M.F., 2010. Experimental Neurology. 282 - 293. 2. 223. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952583554&partnerID=MN8TOARS . 10.1016/j.expneurol.2009.09.013 . Experimental Neurology

Communication between endoplamic reticulum and mitochondria in the neuronal death induced by amyloid-beta peptide

Ferreiro, E.; Costa, R.; Resende, R.; Marques, S.; Cardoso, S.; Oliveira, C. R.; Pereira, C., 2009. Journal of the Neurological Sciences. 280 - 281. 1-2. 283. 2009. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000268609400202&KeyUID=WOS:000268609400202 . 10.1016/j.jns.2009.02.158 . Journal of the Neurological Sciences

Statins prevent beta-amyloid-induced toxicity in cortical neurons

Pereira, Cláudia; Fonseca, Ana Catarina Ribeiro da Graça; Resende, Rosa; Ferreiro, Elisabete; Resende de Oliveira, Catarina; Pereira, C. M. F.; Fonseca, A. C.; et al, 2009. Journal of the Neurological Sciences. 281 - 281. 1. 283. 2009. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000268609400203&KeyUID=WOS:000268609400203 . 10.1016/j.jns.2009.02.159 . published Journal of the Neurological Sciences

Mitochondria as a therapeutic target in Alzheimer's disease and diabetes

Moreira, P.I.; Cardoso, S.M.; Pereira, C.M.; Santos, M.S.; Oliveira, C.R., 2009. CNS and Neurological Disorders - Drug Targets. 492 - 511. 6. 8. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-75849136180&partnerID=MN8TOARS . 10.2174/187152709789824651 . CNS and Neurological Disorders - Drug Targets

Neuroprotective effects of statins in an in vitro model of alzheimer's disease

Fonseca, A.C.R.G.; Proena, T.; Resende, R.; Oliveira, C.R.; Pereira, C.M.F., 2009. Journal of Alzheimer's Disease. 503 - 517. 3. 17. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-67849099662&partnerID=MN8TOARS . 10.3233/JAD-2009-1067 . Journal of Alzheimer's Disease

ER-mediated stress induces mitochondrial-dependent caspases activation in NT2 neuron-like cells

Arduíno, D.M.; Raquel Esteves, A.; Filipa Domingues, A.; Pereira, C.M.F.; Cardoso, S.M.; Oliveira, C.R., 2009. BMB Reports. 719 - 724. 11. 42. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-73449102905&partnerID=MN8TOARS . BMB Reports

The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway

Ferreiro, E.; Oliveira, C.R.; Pereira, C.M.F., 2008. Neurobiology of Disease. 331 - 342. 3. 30. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-43649083316&partnerID=MN8TOARS . 10.1016/j.nbd.2008.02.003 . Neurobiology of Disease

ER stress is involved in Aß-induced GSK-3ß activation and tau phosphorylation

Resende, R.; Ferreiro, E.; Pereira, C.; Oliveira, C.R., 2008. Journal of Neuroscience Research. 2091 - 2099. 9. 86. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-48249157930&partnerID=MN8TOARS . 10.1002/jnr.21648 . Journal of Neuroscience Research

Involvement of mitochondria in endoplasmic reticulum stress-induced apoptotic cell death pathway triggered by the prion peptide PrP 106-126

Ferreiro, E.; Costa, R.; Marques, S.; Cardoso, S.M.; Oliveira, C.R.; Pereira, C.M.F., 2008. Journal of Neurochemistry. 766 - 776. 3. 104. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-38049162500&partnerID=MN8TOARS . 10.1111/j.1471-4159.2007.05048.x . Journal of Neurochemistry

Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease

Resende, R.; Moreira, P.I.; Proença, T.; Deshpande, A.; Busciglio, J.; Pereira, C.; Oliveira, C.R., 2008. Free Radical Biology and Medicine. 2051 - 2057. 12. 44. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-43849096294&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2008.03.012 . Free Radical Biology and Medicine

Cross-talk between endoplasmic reticulum and mitochondria in the neurotoxicity induced by Alzheimer's disease–associated beta-amyloid peptide

Pereira, Cláudia; Ferreiro, Elisabete; Costa, Rui Miguel Oliveira da; Resende, Rosa; Morais Cardoso, Sandra; Resende de Oliveira, Catarina, 2008. Alzheimer’s and Dementia . T345 - T345. 4. 4. 2008. published Alzheimer’s and Dementia

Neurotoxic effect of oligomeric and fibrillar species of amyloid-beta peptide 1-42: Involvement of endoplasmic reticulum calcium release in oligomer-induced cell death

Resende, R.; Ferreiro, E.; Pereira, C.; Resende de Oliveira, C., 2008. Neuroscience. 725 - 737. 3. 155. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-49249118742&partnerID=MN8TOARS . 10.1016/j.neuroscience.2008.06.036 . Neuroscience

Bcl-2 overexpression protects against amyloid-beta and prion toxicity in GT1-7 neural cells

Ferreiro, Elisabete; Eufrasio, Ana; Pereira, Claudia; Oliveira, Catarina R.; Rego, A. Cristina; Ferreiro, E.; Eufrásio, A.; et al, 2007. Journal of Alzheimers Disease. 223 - 228. 3. 12. 2007. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000252300000003&KeyUID=WOS:000252300000003 . Journal of Alzheimers Disease

Susceptibility of hippocampal neurons to Aß peptide toxicity is associated with perturbation of Ca2+ homeostasis

Resende, R.; Pereira, C.; Agostinho, P.; Vieira, A.P.; Malva, J.O.; Oliveira, C.R., 2007. Brain Research. 11 - 21. 1. 1143. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947303240&partnerID=MN8TOARS . 10.1016/j.brainres.2007.01.071 . Brain Research

Neurodegeneration in Alzheimer's disease: Inter-organelle cross-talk and oxidative stress in cell life and death decisions

Ferreiro, Elisabete; Resende, Rosa; Costa, Rui Miguel Oliveira da; Moreira, Paula Isabel; Morais Cardoso, Sandra; Pereira, Cláudia; Resende de Oliveira, Catarina; et al, 2007. Free Radical Research. S11 - S11. 41. 2007. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000252296300021&KeyUID=WOS:000252296300021 . Free Radical Research

Does mitochondria impairment affect endoplasmic reticulum function during amyloid-beta toxicity?

Costa, R.; Ferreiro, E.; Oliveira, C. R.; Pereira, C.; Costa, Rui Miguel Oliveira da; Ferreiro, Elisabete; Resende de Oliveira, Catarina; Pereira, Cláudia, 2007. Journal of Neurochemistry. 68 - 69. Supplement. 102. 2007. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000248991600162&KeyUID=WOS:000248991600162 . published Journal of Neurochemistry

In vitro study of Amyloid-ß peptide toxicity. The role of physical state.

Resende, Rosa; Batista, M; Pereira, Cláudia; Resende de Oliveira, Catarina, 2006. Proceedings of the 10th International Conference on Alzheimer’s Disease and Related Disorders. 455 - 459. 2006. published Proceedings of the 10th International Conference on Alzheimer’s Disease and Related Disorders

An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and amyloid-beta peptides neurotoxicity

Ferreiro, E.; Resende, R.; Costa, R.; Oliveira, C.R.; Pereira, C.M.F., 2006. Neurobiology of Disease. 669 - 678. 3. 23. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33747195017&partnerID=MN8TOARS . 10.1016/j.nbd.2006.05.011 . Neurobiology of Disease

The crosstalk between the endoplasmic reticulum and mitochondria in Alzheimer's disease

Cardoso, SM; Ferreiro, E; Oliveira, CR; Pereira, C, 2005. Febs Journal. 55 - 55. 272. 2005. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000234826100186&KeyUID=WOS:000234826100186 . Febs Journal

Neurodegenerative pathways in Parkinson's disease: Therapeutic strategies

Cardoso, S.M.; Moreira, P.I.; Agostinho, P.; Pereira, C.; Oliveira, C.R., 2005. Current Drug Targets: CNS and Neurological Disorders. 405 - 419. 4. 4. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-23144431757&partnerID=MN8TOARS . 10.2174/1568007054546072 . Current Drug Targets: CNS and Neurological Disorders

Protective effect of zinc on amyloid-ß 25-35 and 1-40 mediated toxicity

Cardoso, S.M.; Rego, A.C.; Pereira, C.; Oliveira, C.R., 2005. Neurotoxicity Research. 273 - 281. 4. 7. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-27744456147&partnerID=MN8TOARS . 10.1007/BF03033885 . Neurotoxicity Research

Aeroallergens sensitization in an allergic paediatric population of Cova da Beira, Portugal.

Loureiro, G; Rabaca, M A; Blanco, B; Andrade, S; Chieira, C; Pereira, C, 2005. Allergologia et immunopathologia. 192 - 8. 4. 33. 2005. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:16045856&KeyUID=MEDLINE:16045856 . 10.1157/13077742 . Allergologia et immunopathologia

Mechanism of amyloid-beta induced early synaptotoxicity.

Ferreiro, Elisabete; Resende, Rosa; Resende de Oliveira, Catarina; Pereira, Cláudia, 2005. Sinapse. 101 - 101. 1. 5 . 2005. published Sinapse

Endoplasmic reticulum dysfunction and oxidative stress induced by the prion peptide

Ferreiro, EB; Oliveira, CR; Pereira, CM, 2005. Journal of Neurochemistry. 174 - 175. 94. 2005. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000231673401076&KeyUID=WOS:000231673401076 . Journal of Neurochemistry

Alzheimer's disease-associated neurotoxic mechanisms and neuroprotective strategies

Pereira, C.; Agostinho, P.; Moreira, P.I.; Cardoso, S.M.; Oliveira, C.R., 2005. Current Drug Targets: CNS and Neurological Disorders. 383 - 403. 4. 4. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-23144463734&partnerID=MN8TOARS . 10.2174/1568007054546117 . Current Drug Targets: CNS and Neurological Disorders

Involvement of endoplasmic reticulum Ca2+ release through ryanodine and inositol 1,4,5-triphosphate receptors in the neurotoxic effects induced by the amyloid-ß peptide

Ferreiro, E.; Oliveira, C.R.; Pereira, C.M.F., 2004. Journal of Neuroscience Research. 872 - 880. 6. 76. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-2642541799&partnerID=MN8TOARS . 10.1002/jnr.20135 . Journal of Neuroscience Research

Cell degeneration induced by amyloid-ß peptides: Implications for Alzheimer's disease

Pereira, C.; Ferreiro, E.; Cardoso, S.M.; De Oliveira, C.R.; Pereira, C; Ferreiro, E; Cardoso, SM; de Oliveira, CR, 2004. Journal of Molecular Neuroscience. 97 - 104. 1-2. 23. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-4344669435&partnerID=MN8TOARS . 10.1385/JMN:23:1-2:097 . Journal of Molecular Neuroscience

[Neuroprotection strategies: effect of vinpocetine in vitro oxidative stress models].

Pereira, Claudia; Agostinho, Paula; Moreira, Paula I; Duarte, Ana I; Santos, Maria S; Oliveira, Catarina R, 2003. Acta medica portuguesa. 401 - 6. 6. 16. 2003. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:15631851&KeyUID=MEDLINE:15631851 . Acta medica portuguesa

Neuroprotection strategies: Effect of vinpocetinein in vitro oxidative stress models | Estratégias de neuroprotecção: Efeito da vimpocetina em modelos in vitro de stresse oxidativo

Pereira, C.; Agostinho, P.; Moreira, P.I.; Duarte, A.I.; Santos, M.S.; Oliveira, C.R., 2003. Acta Medica Portuguesa. 401 - 406. 6. 16. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-9644310235&partnerID=MN8TOARS . Acta Medica Portuguesa

Susceptibility to ß-amyloid-induced toxicity is decreased in Goto- Kakizaki diabetic rats: Involvement of oxidative stress

Pereira, C.; Moreira, P.; Seiça, R.; Santos, M.S.; Oliveira, C.R., 2000. Experimental Neurology. 383 - 391. 1. 161. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034051172&partnerID=MN8TOARS . 10.1006/exnr.1999.7270 . Experimental Neurology

Effect of Zinc Ions on the Cytotoxicity Induced by the Amyloid beta-Peptide

Moreira, Paula; Pereira, Claudia; Santos, Maria S.; Oliveira, Catarina, 2000. Antioxidants & Redox Signaling. 317 - 325. 2. 2. 2000. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000207500700014&KeyUID=WOS:000207500700014 . 10.1089/ars.2000.2.2-317 . Antioxidants & Redox Signaling

Oxidative glutamate toxicity involves mitochondrial dysfunction and perturbation of intracellular Ca2+ homeostasis

Pereira, CF; de Oliveira, CR, 2000. Neuroscience Research. 227 - 236. 3. 37. 2000. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000088427400008&KeyUID=WOS:000088427400008 . 10.1016/S0168-0102(00)00124-3 . Neuroscience Research

Vinpocetine attenuates the metabolic dysfunction induced by amyloid beta-peptides in PC12 cells

Pereira, C; Agostinho, P; Oliveira, CR; Pereira, C.; Agostinho, P.; Oliveira, C.R., 2000. Free Radical Research. 497 - 506. 5. 33. 2000. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000166441800006&KeyUID=WOS:000166441800006 . 10.1080/10715760000301041 . Free Radical Research

Effect of zinc ions on the cytotoxicity induced by the amyloid ß- peptide

Moreira, P.; Pereira, C.; Santos, M.S.; Oliveira, C., 2000. Antioxidants and Redox Signaling. 317 - 325. 2. 2. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033949740&partnerID=MN8TOARS . Antioxidants and Redox Signaling

Mitochondrial function is differentially affected upon oxidative stress

Cardoso, S.M.; Pereira, C.; Oliveira, C.R., 1999. Free Radical Biology and Medicine. 3 - 13. 1-2. 26. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0345222531&partnerID=MN8TOARS . 10.1016/S0891-5849(98)00205-6 . Free Radical Biology and Medicine

Involvement of oxidative stress on the impairment of energy metabolism induced by Aß peptides on PC12 cells: Protection by antioxidants

Pereira, C.; Santos, M.S.; Oliveira, C., 1999. Neurobiology of Disease. 209 - 219. 3. 6. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033022771&partnerID=MN8TOARS . 10.1006/nbdi.1999.0241 . Neurobiology of Disease

Metabolic inhibition increases glutamate susceptibility on a PC12 cell line

Pereira, C; Santos, MS; Oliveira, C; Pereira, C.; Santos, M.S.; Oliveira, C., 1998. Journal of Neuroscience Research. 360 - 370. 3. 51. 1998. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000071805700009&KeyUID=WOS:000071805700009 . 10.1002/(SICI)1097-4547(19980201)51:3<360::AID-JNR9>3.3.CO;2-7 . Journal of Neuroscience Research

Mitochondrial function impairment induced by amyloid beta-peptide on PC12 cells

Pereira, C; Santos, MS; Oliveira, C; Pereira, C.; Santos, M.S.; Oliveira, C., 1998. Neuroreport. 1749 - 1755. 8. 9. 1998. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000074198700015&KeyUID=WOS:000074198700015 . 10.1097/00001756-199806010-00015 . Neuroreport

The protective effect of vitamin E, idebenone and reduced glutathione on free radical mediated injury in rat brain synaptosomes

Cardoso, S.M.; Pereira, C.; Oliveira, C.R., 1998. Biochemical and Biophysical Research Communications. 703 - 710. 3. 246. 1998. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032577242&partnerID=MN8TOARS . 10.1006/bbrc.1998.8563 . Biochemical and Biophysical Research Communications

Glutamate toxicity on a PC12 cell line involves glutathione (GSH) depletion and oxidative stress

Pereira, C.M.F.; Oliveira, C.R., 1997. Free Radical Biology and Medicine. 637 - 647. 4. 23. 1997. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030757990&partnerID=MN8TOARS . 10.1016/S0891-5849(97)00020-8 . Free Radical Biology and Medicine

Contribution of plasma membrane and endoplasmic reticulum Ca2+-ATPases to the synaptosomal [Ca2+]i increase during oxidative stress

Pereira, C.; Ferreira, C.; Carvalho, C.; Oliveira, C., 1996. Brain Research. 269 - 277. 1-2. 713. 1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029928472&partnerID=MN8TOARS . 10.1016/0006-8993(95)01554-X . Brain Research

Effect of lipid peroxidation on [Ca2+]i of rat synaptosomes

Pereira, Cláudia; Resende de Oliveira, Catarina, 1993. Journal of Neurochemistry. S151D - S151D. supplement. 1993. published Journal of Neurochemistry

Awards

2021

"Women in Science” tribute to Portuguese women scientists, Ciência Viva

2004

“L’Oréal Award for Women in Science”, 1st edition, L’Oréal Portugal/UNESCO/FCT

2018

Merit fellowship from the University of Coimbra”, awarded Ana Catarina Pereira (Master's Program in Cellular and Molecular Biology)

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