Neuroscience and Disease
Ageing Brain
Ageing
Ageing
As we age, our nervous system and brain undergo natural, and sometimes pathological, changes. Together with our collaborators, we study the changes in neuronal and synaptic morphology and functions with aging. More specifically, we aim to understand molecular and cellular processes at the neuronal synapse that deteriorate with age, and lead to increased disease susceptibility. To tackle these questions, we use murine and human cellular model systems, and employ electrophysiology and advanced imaging.
Information about journal articles, updated at 05-04-2026, from platform CIÊNCIAVITAE.
Dynamins maintain nuclear envelope homeostasis and genome stability
Aveleira, Célia; Martial, Thibaud; Carrique, Loïc; Gaspar, Rita; Caulino-Rocha, Ana; Myatt, Izaak; Wendler, Franz; et al, 2026. Nature Communications. 1. 17. 2026. https://doi.org/10.1038/s41467-025-68130-4 . 10.1038/s41467-025-68130-4 . Nature Communications
Loss of the lysosomal protein CLN3 triggers c-Abl-dependent YAP1 pro-apoptotic signaling
Domingues, Neuza; Calcagni’, Alessia; Freire, Sofia; Pires, Joana; Casqueiro, Ricardo; Salazar, Ivan L; Herz, Niculin Joachim; et al, 2025. EMBO Reports. 6096 - 6120. 24. 26. 2025. https://doi.org/10.1038/s44319-025-00613-3 . 10.1038/s44319-025-00613-3 . EMBO Reports
Intersectin and endophilin condensates prime synaptic vesicles for release site replenishment
Ogunmowo, Tyler H.; Hoffmann, Christian; Patel, Chintan; Pepper, Renee; Wang, Han; Gowrisankaran, Sindhuja; Idel, Johanna; et al, 2025. Nature Neuroscience. 1649 - 1662. 8. 28. 2025. https://doi.org/10.1038/s41593-025-02002-4 . 10.1038/s41593-025-02002-4 . Nature Neuroscience
Role of lipids in interorganelle communication
Domingues, Neuza; Pires, Joana; Milosevic, Ira; Raimundo, Nuno, 2025. Trends in Cell Biology. 46 - 58. 1. 35. 2025. https://doi.org/10.1016/j.tcb.2024.04.008 . 10.1016/j.tcb.2024.04.008 . Trends in Cell Biology
Upregulation of cholesterol synthesis by lysosomal defects requires a functional mitochondrial respiratory chain
Agostini, Francesco; Pereyra, Leonardo; Dale, Justin; Yambire, King Faisal; Maglioni, Silvia; Schiavi, Alfonso; Ventura, Natascia; Milosevic, Ira; Raimundo, Nuno, 2024. Journal of Biological Chemistry. 7. 300. 2024. https://doi.org/10.1016/j.jbc.2024.107403 . 10.1016/j.jbc.2024.107403 . Journal of Biological Chemistry
MiR-186-5p inhibition restores synaptic transmission and neuronal network activity in a model of chronic stress
Rodrigues, Beatriz; Leitão, Ricardo A.; Santos, Mónica; Trofimov, Alexander; Silva, Mariline; Inácio, Ângela S.; Abreu, Mónica; et al, 2024. Molecular Psychiatry. 1034 - 1046. 3. 30. 2024. https://doi.org/10.1038/s41380-024-02715-1 . 10.1038/s41380-024-02715-1 . Molecular Psychiatry
Connexin43 promotes exocytosis of damaged lysosomes through actin remodelling
Domingues, Neuza; Catarino, Steve; Cristóvão, Beatriz; Rodrigues, Lisa; Carvalho, Filomena A; Sarmento, Maria João; Zuzarte, Mónica; et al, 2024. The EMBO Journal. 3627 - 3649. 17. 43. 2024. https://doi.org/10.1038/s44318-024-00177-3 . 10.1038/s44318-024-00177-3 . The EMBO Journal
TEX264 drives selective autophagy of DNA lesions to promote DNA repair and cell survival
Lascaux, Pauline; Hoslett, Gwendoline; Tribble, Sara; Trugenberger, Camilla; Anticevic, Ivan; Otten, Cecile; Torrecilla, Ignacio; et al, 2024. Cell. 5698 - 5718.e26. 20. 187. 2024. https://doi.org/10.1016/j.cell.2024.08.020 . 10.1016/j.cell.2024.08.020 . Cell
Role of lipids in inter-organelle communication
Domingues, Neuza; Joana F. Pires; Milosevic, Ira; Raimundo, Nuno, 2024. Trends in Cell Biology. 2024. in press Trends in Cell Biology
Lack of peroxisomal catalase affects heat shock response in<i>Caenorhabditis elegans</i>
Musa, Marina; Dionisio, Pedro A; Casqueiro, Ricardo; Milosevic, Ira; Raimundo, Nuno; Krisko, Anita, 2022. Life Science Alliance. 1. 6. 2022. http://dx.doi.org/10.26508/lsa.202201737 . 10.26508/lsa.202201737 . published Life Science Alliance
Colocalization of different neurotransmitter transporters on synaptic vesicles is sparse except for VGLUT1 and ZnT3
Upmanyu, Neha; Jin, Jialin; Emde, Henrik von der; Ganzella, Marcelo; Bösche, Leon; Malviya, Viveka Nand; Zhuleku, Evi; et al, 2022. Neuron. 1483 - 1497.e7. 9. 110. 2022. http://dx.doi.org/10.1016/j.neuron.2022.02.008 . 10.1016/j.neuron.2022.02.008 . published Neuron
Fine-tuning activity-dependent bulk endocytosis via kinases and phosphatases
Milosevic, Ira; Cousin, Michael A., 2021. Journal of Cell Biology. 12. 220. 2021. http://dx.doi.org/10.1083/jcb.202111056 . 10.1083/jcb.202111056 . published Journal of Cell Biology
Spatial and Temporal Aspects of Exocytosis Studied on the Isolated Plasma Membranes
Milosevic, Ira, 2021. Methods Mol Biol. 311 - 313. 2233. 2021. PMID: 33222144 DOI: 10.1007/978-1-0716-1044-2_21 . published Methods Mol Biol
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)<sup>1</sup>
Klionsky, Daniel J.; Abdel-Aziz, Amal Kamal; Abdelfatah, Sara; Abdellatif, Mahmoud; Abdoli, Asghar; Abel, Steffen; Abeliovich, Hagai; et al, 2021. Autophagy. 1 - 382. 1. 17. 2021. http://dx.doi.org/10.1080/15548627.2020.1797280 . 10.1080/15548627.2020.1797280 . published Autophagy
Targeting synaptic plasticity in schizophrenia: insights from genomic studies
Mould, Arne W.; Hall, Nicola A.; Milosevic, Ira; Tunbridge, Elizabeth M., 2021. Trends in Molecular Medicine. 1022 - 1032. 11. 27. 2021. http://dx.doi.org/10.1016/j.molmed.2021.07.014 . 10.1016/j.molmed.2021.07.014 . published Trends in Molecular Medicine
Vps34 derived phosphatidylinositol 3-monophosphate modulates megakaryocyte maturation and proplatelet production through late endosomes/lysosomes
Bertovic, Ivana; Kurelic, Roberta; Miloševic, Ira; Bender, Markus; Krauss, Michael; Haucke, Volker; Jurak Begonja, Antonija, 2020. Journal of Thrombosis and Haemostasis. 2020. https://pubmed.ncbi.nlm.nih.gov/32056354/?from_term=Milosevic+I&from_sort=date&from_pos=5 . 10.1111/jth.14764 . in press Journal of Thrombosis and Haemostasis
Cooperativity of membrane-protein and protein–protein interactions control membrane remodeling by epsin 1 and affects clathrin-mediated endocytosis
Kroppen, Benjamin; Teske, Nelli; Yambire, King F.; Denkert, Niels; Mukherjee, Indrani; Tarasenko, Daryna; Jaipuria, Garima; et al, 2020. Cellular and Molecular Life Sciences. 2020. http://dx.doi.org/10.1007/s00018-020-03647-z . 10.1007/s00018-020-03647-z . Cellular and Molecular Life Sciences
Regulation of synaptic vesicle acidification at the neuronal synapse
Gowrisankaran, Sindhuja; Milosevic, Ira, 2020. IUBMB Life. 2020. http://dx.doi.org/10.1002/iub.2235 . 10.1002/iub.2235 . published IUBMB Life
Endophilin-A controls recruitment, priming and fusion of neurosecretory vesicles via intersectin
Milosevic, Ira, 2020. Nat Comm. 2020. https://pubmed.ncbi.nlm.nih.gov/32152276/?from_term=Milosevic+I&from_sort=date&from_pos=1 . in press Nat Comm
PI(4,5)P2-dependent regulation of exocytosis by amisyn, a vertebrate-specific competitor of synaptobrevin 2
Milosevic, Ira, 2020. PNAS USA. 2020. accepted PNAS USA
ATP hydrolysis by yeast Hsp104 determines protein aggregate dissolution and size in vivo
Sathyanarayanan, Udhayabhaskar; Musa, Marina; Bou Dib, Peter; Raimundo, Nuno; Milosevic, Ira; Krisko, Anita, 2020. Nature Communications. 1. 11. 2020. http://dx.doi.org/10.1038/s41467-020-19104-1 . 10.1038/s41467-020-19104-1 . Nature Communications
AP180 promotes release site clearance and clathrin-dependent vesicle reformation in mouse cochlear inner hair cells
Kroll, Jana; Özçete, Özge Demet; Jung, Sangyong; Maritzen, Tanja; Milosevic, Ira; Wichmann, Carolin; Moser, Tobias, 2019. Journal of Cell Science. 2. 133. 2019. http://dx.doi.org/10.1242/jcs.236737 . 10.1242/jcs.236737 . published Journal of Cell Science
Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo
Yambire, King Faisal; Rostosky, Christine; Watanabe, Takashi; Pacheu-Grau, David; Torres-Odio, Sylvia; Sanchez-Guerrero, Angela; Senderovich, Ola; et al, 2019. eLife. 8. 2019. https://pubmed.ncbi.nlm.nih.gov/30917721/?from_term=Milosevic+I+G%C3%B6ttingen&from_sort=date&from_pos=8 . 10.7554/elife.51031 . published eLife
The Synaptic Vesicle Cycle Revisited: New Insights into the Modes and Mechanisms
Chanaday, Natali L.; Cousin, Michael A.; Milosevic, Ira; Watanabe, Shigeki; Morgan, Jennifer R., 2019. The Journal of Neuroscience. 8209 - 8216. 42. 39. 2019. http://dx.doi.org/10.1523/jneurosci.1158-19.2019 . 10.1523/jneurosci.1158-19.2019 . published The Journal of Neuroscience
Mitochondrial fission requires DRP1 but not dynamins
Fonseca, Tiago Branco; Sánchez-Guerrero, Ángela; Milosevic, Ira; Raimundo, Nuno, 2019. Nature. E34 - E42. 7761. 570. 2019. http://dx.doi.org/10.1038/s41586-019-1296-y . 10.1038/s41586-019-1296-y . published Nature
Mitochondrial respiratory chain deficiency inhibits lysosomal hydrolysis
Fernandez-Mosquera, Lorena; Yambire, King Faisal; Couto, Renata; Pereyra, Leonardo; Pabis, Kamil; Ponsford, Amy H.; Diogo, Cátia V.; et al, 2019. Autophagy. 1572 - 1591. 9. 15. 2019. http://dx.doi.org/10.1080/15548627.2019.1586256 . 10.1080/15548627.2019.1586256 . published Autophagy
Mitochondrial biogenesis is transcriptionally repressed in lysosomal lipid storage diseases
Yambire, King Faisal; Fernandez-Mosquera, Lorena; Steinfeld, Robert; Mühle, Christiane; Ikonen, Elina; Milosevic, Ira; Raimundo, Nuno, 2019. eLife. 8. 2019. http://dx.doi.org/10.7554/elife.39598 . 10.7554/elife.39598 . published eLife
Cells Control BIN1-Mediated Membrane Tubulation by Altering the Membrane Charge
Gowrisankaran, Sindhuja; Wang, Zuoneng; Morgan, David G.; Milosevic, Ira; Mim, Carsten, 2019. Journal of Molecular Biology. 2019. http://dx.doi.org/10.1016/j.jmb.2019.12.001 . 10.1016/j.jmb.2019.12.001 . published Journal of Molecular Biology
Endophilin-A regulates presynaptic Ca 2+ influx and synaptic vesicle recycling in auditory hair cells
Kroll, Jana; Jaime Tobón, Lina M; Vogl, Christian; Neef, Jakob; Kondratiuk, Ilona; König, Melanie; Strenzke, Nicola; et al, 2019. The EMBO Journal. 5. 38. 2019. http://dx.doi.org/10.15252/embj.2018100116 . 10.15252/embj.2018100116 . published The EMBO Journal
Membrane binding, internalization, and sorting of alpha-synuclein in the cell
Masaracchia, Caterina; Hnida, Marilena; Gerhardt, Ellen; Lopes da Fonseca, Tomás; Villar-Pique, Anna; Branco, Tiago; Stahlberg, Markus A.; et al, 2018. Acta Neuropathologica Communications. 1. 6. 2018. http://dx.doi.org/10.1186/s40478-018-0578-1 . 10.1186/s40478-018-0578-1 . published Acta Neuropathologica Communications
Clathrin coat controls synaptic vesicle acidification by blocking vacuolar ATPase activity
Farsi, Zohreh; Gowrisankaran, Sindhuja; Krunic, Matija; Rammner, Burkhard; Woehler, Andrew; Lafer, Eileen M; Mim, Carsten; Jahn, Reinhard; Milosevic, Ira, 2018. eLife. 7. 2018. http://dx.doi.org/10.7554/elife.32569 . 10.7554/elife.32569 . published eLife
Heat-induced longevity in budding yeast requires respiratory metabolism and glutathione recycling
Musa, Marina; Peric, Matea; Bou Dib, Peter; Sobocanec, Sandra; Šaric, Ana; Lovric, Anita; Rudan, Marina; et al, 2018. Aging. 2407 - 2427. 9. 10. 2018. http://dx.doi.org/10.18632/aging.101560 . 10.18632/aging.101560 . published Aging
Synaptojanin and Endophilin Mediate Neck Formation during Ultrafast Endocytosis
Watanabe, Shigeki; Mamer, Lauren Elizabeth; Raychaudhuri, Sumana; Luvsanjav, Delgermaa; Eisen, Julia; Trimbuch, Thorsten; Söhl-Kielczynski, Berit; et al, 2018. Neuron. 1184 - 1197.e6. 6. 98. 2018. http://dx.doi.org/10.1016/j.neuron.2018.06.005 . 10.1016/j.neuron.2018.06.005 . published Neuron
Revisiting the Role of Clathrin-Mediated Endoytosis in Synaptic Vesicle Recycling
Milosevic, Ira, 2018. Frontiers in Cellular Neuroscience. 12. 2018. http://dx.doi.org/10.3389/fncel.2018.00027 . 10.3389/fncel.2018.00027 . published Frontiers in Cellular Neuroscience
TORC1-mediated sensing of chaperone activity alters glucose metabolism and extends lifespan
Peric, Matea; Lovric, Anita; Šaric, Ana; Musa, Marina; Bou Dib, Peter; Rudan, Marina; Nikolic, Andrea; et al, 2017. Aging Cell. 994 - 1005. 5. 16. 2017. http://dx.doi.org/10.1111/acel.12623 . 10.1111/acel.12623 . published Aging Cell
Acute and chronic mitochondrial respiratory chain deficiency differentially regulate lysosomal biogenesis
Fernández-Mosquera, Lorena; Diogo, Cátia V.; Yambire, King Faisal; Santos, Gabriela L.; Luna Sánchez, Marta; Bénit, Paule; Rustin, Pierre; et al, 2017. Scientific Reports. 1. 7. 2017. http://dx.doi.org/10.1038/srep45076 . 10.1038/srep45076 . published Scientific Reports
YKL-40 in the brain and cerebrospinal fluid of neurodegenerative dementias
Llorens, Franc; Thüne, Katrin; Tahir, Waqas; Kanata, Eirini; Diaz-Lucena, Daniela; Xanthopoulos, Konstantinos; Kovatsi, Eleni; et al, 2017. Molecular Neurodegeneration. 1. 12. 2017. http://dx.doi.org/10.1186/s13024-017-0226-4 . 10.1186/s13024-017-0226-4 . published Molecular Neurodegeneration
PICK1 regulates AMPA receptor endocytosis via direct interactions with AP2 a-appendage and dynamin
Fiuza, Maria; Rostosky, Christine M.; Parkinson, Gabrielle T.; Bygrave, Alexei M.; Halemani, Nagaraj; Baptista, Marcio; Milosevic, Ira; Hanley, Jonathan G., 2017. The Journal of Cell Biology. 3323 - 3338. 10. 216. 2017. http://dx.doi.org/10.1083/jcb.201701034 . 10.1083/jcb.201701034 . published The Journal of Cell Biology
Environmental and genetic factors support the dissociation between a-synuclein aggregation and toxicity
Villar-Piqué, Anna; Lopes da Fonseca, Tomás; Sant’Anna, Ricardo; Szegö, Éva Mónika; Fonseca-Ornelas, Luis; Pinho, Raquel; Carija, Anita; et al, 2016. Proceedings of the National Academy of Sciences. E6506 - E6515. 42. 113. 2016. http://dx.doi.org/10.1073/pnas.1606791113 . 10.1073/pnas.1606791113 . published Proceedings of the National Academy of Sciences
Endophilin-A Deficiency Induces the Foxo3a-Fbxo32 Network in the Brain and Causes Dysregulation of Autophagy and the Ubiquitin-Proteasome System
Murdoch, John D.; Rostosky, Christine M.; Gowrisankaran, Sindhuja; Arora, Amandeep S.; Soukup, Sandra-Fausia; Vidal, Ramon; Capece, Vincenzo; et al, 2016. Cell Reports. 1071 - 1086. 4. 17. 2016. http://dx.doi.org/10.1016/j.celrep.2016.09.058 . 10.1016/j.celrep.2016.09.058 . published Cell Reports
Vesicle uncoating regulated by SH 3- SH 3 domain-mediated complex formation between endophilin and intersectin at synapses
Pechstein, Arndt; Gerth, Fabian; Milosevic, Ira; Jäpel, Maria; Eichhorn-Grünig, Marielle; Vorontsova, Olga; Bacetic, Jelena; et al, 2014. EMBO reports. 232 - 239. 2. 16. 2014. http://dx.doi.org/10.15252/embr.201439260 . 10.15252/embr.201439260 . published EMBO reports
Upregulation of Parkin in Endophilin Mutant Mice
Cao, Mian; Milosevic, Ira; Giovedi, Silvia; De Camilli, Pietro, 2014. The Journal of Neuroscience. 16544 - 16549. 49. 34. 2014. http://dx.doi.org/10.1523/jneurosci.1710-14.2014 . 10.1523/jneurosci.1710-14.2014 . published The Journal of Neuroscience
Coupling between endocytosis and sphingosine kinase 1 recruitment
Shen, Hongying; Giordano, Francesca; Wu, Yumei; Chan, Jason; Zhu, Chen; Milosevic, Ira; Wu, Xudong; et al, 2014. Nature Cell Biology. 652 - 662. 7. 16. 2014. http://dx.doi.org/10.1038/ncb2987 . 10.1038/ncb2987 . published Nature Cell Biology
PI(4,5)P2-Dependent and Ca2+-Regulated ER-PM Interactions Mediated by the Extended Synaptotagmins
Giordano, Francesca; Saheki, Yasunori; Idevall-Hagren, Olof; Colombo, Sara Francesca; Pirruccello, Michelle; Milosevic, Ira; Gracheva, Elena O.; et al, 2013. Cell. 1494 - 1509. 7. 153. 2013. http://dx.doi.org/10.1016/j.cell.2013.05.026 . 10.1016/j.cell.2013.05.026 . published Cell
Role of dynamin, synaptojanin, and endophilin in podocyte foot processes
Soda, Keita; Balkin, Daniel M.; Ferguson, Shawn M.; Paradise, Summer; Milosevic, Ira; Giovedi, Silvia; Volpicelli-Daley, Laura; et al, 2012. Journal of Clinical Investigation. 4401 - 4411. 12. 122. 2012. http://dx.doi.org/10.1172/jci65289 . 10.1172/jci65289 . published Journal of Clinical Investigation
Recruitment of Endophilin to Clathrin-Coated Pit Necks Is Required for Efficient Vesicle Uncoating after Fission
Milosevic, Ira; Giovedi, Silvia; Lou, Xuelin; Raimondi, Andrea; Collesi, Chiara; Shen, Hongying; Paradise, Summer; et al, 2011. Neuron. 587 - 601. 4. 72. 2011. http://dx.doi.org/10.1016/j.neuron.2011.08.029 . 10.1016/j.neuron.2011.08.029 . published Neuron
The SNAP-25 Linker as an Adaptation Toward Fast Exocytosis
Nagy, Gábor; Milosevic, Ira; Mohrmann, Ralf; Wiederhold, Katrin; Walter, Alexander M.; Sørensen, Jakob B., 2008. Molecular Biology of the Cell. 3769 - 3781. 9. 19. 2008. http://dx.doi.org/10.1091/mbc.e07-12-1218 . 10.1091/mbc.e07-12-1218 . published Molecular Biology of the Cell
Munc18-1: Sequential Interactions with the Fusion Machinery Stimulate Vesicle Docking and Priming
Gulyas-Kovacs, A.; de Wit, H.; Milosevic, I.; Kochubey, O.; Toonen, R.; Klingauf, J.; Verhage, M.; Sorensen, J. B., 2007. Journal of Neuroscience. 8676 - 8686. 32. 27. 2007. http://dx.doi.org/10.1523/jneurosci.0658-07.2007 . 10.1523/jneurosci.0658-07.2007 . published Journal of Neuroscience
Sequential N- to C-terminal SNARE complex assembly drives priming and fusion of secretory vesicles
Sørensen, Jakob B; Wiederhold, Katrin; Müller, Emil M; Milosevic, Ira; Nagy, Gábor; de Groot, Bert L; Grubmüller, Helmut; Fasshauer, Dirk, 2006. The EMBO Journal. 955 - 966. 5. 25. 2006. http://dx.doi.org/10.1038/sj.emboj.7601003 . 10.1038/sj.emboj.7601003 . published The EMBO Journal
Alternative Splicing of SNAP-25 Regulates Secretion through Nonconservative Substitutions in the SNARE Domain
Nagy, Gábor; Milosevic, Ira; Fasshauer, Dirk; Müller, E. Matthias; de Groot, Bert L.; Lang, Thorsten; Wilson, Michael C.; Sørensen, Jakob B., 2005. Molecular Biology of the Cell. 5675 - 5685. 12. 16. 2005. http://dx.doi.org/10.1091/mbc.e05-07-0595 . 10.1091/mbc.e05-07-0595 . published Molecular Biology of the Cell
Plasmalemmal Phosphatidylinositol-4,5-Bisphosphate Level Regulates the Releasable Vesicle Pool Size in Chromaffin Cells
Milosevic, I., 2005. Journal of Neuroscience. 2557 - 2565. 10. 25. 2005. http://dx.doi.org/10.1523/jneurosci.3761-04.2005 . 10.1523/jneurosci.3761-04.2005 . published Journal of Neuroscience
5 51 out of 51 Publications
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