Medical Microbiology

Medical Microbiology



Antimicrobial Resistance

Fungal Pathogens

Research lines

Influence of the purinergic system in microbial evasion to the immune system in the elderly

Role of melanin in filamentous fungi pathogenesis and antifungal resistance

Natural extracts as a source of novel antimicrobials

Aerosols as a source of microbial agents


The COVID19 pandemic highlighted the importance of medical microbiology in the preparedness to deal with diseases affecting the human population, particularly infections. Knowing the biology of agents, spreading routes, mechanisms by which these microbes evade the immune system and invade the susceptible host together with novel therapies to cope with the resistance to antimicrobials, is what the Medical Microbiology Research Group at CNC consider its mission in research. One of our objectives is to understand microbial pathogenesis and currently we are focused in understand how Candida spp. can modulate purine metabolism and adenosine A2A receptor to evade the immune system, especially in the elderly, more prone to severe diseases due to infection and to dysbiosis. 

In the context of pathogenesis we are also  studying melanin in the fungal cell wall and in extracellular vesicles,  as an immunomodulator. The spreading of microbes in aerosols, is being studied in what concerns asthma (fungi) and Covid19 (SARS-CoV-2). 

We are seeking for novel antimicrobials extracted from natural resources, an effort aligned with one of the UN 2030 Agenda, in the quest for therapeutic approaches to control biofilms and infection. We are provided with strong expertise in standard clinical microbiology methods but also with molecular biology tools. To accomplish its major goals, the group is using both in vivo and in vitro infection models and human samples, to study, e.g., gut inflammation and respiratory diseases, in collaboration with clinicians fostering interdisciplinarity and translation.


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Information about journal articles, updated at 26-06-2022, from platform CIÊNCIAVITAE.

Delayed Cutaneous Adverse Reaction of the AstraZeneca COVID-19 Vaccine in a Breastfed Female Infant: A Coincidence or a Rare Effect?

Patricia Diogo; Gil Correia; João Brochado Martins; Rui Soares; João Miguel Marques dos Santos; Teresa Gonçalves, 2022. Vaccines. 2022. . 10.3390/vaccines10040602 . Vaccines

Phagolysosomal remodeling to confine Candida albicans in the macrophage

2022. Trends in Microbiology. 2022. . 10.1016/j.tim.2022.03.004 . Trends in Microbiology

Retrospective study of group A Streptococcus oropharyngeal infection diagnosis using a rapid antigenic detection test in a paediatric population from the central region of Portugal

Mendes, Nuno; Miguéis, Carmo; Lindo, Jorge; Gonçalves, Teresa; Miguéis, António, 2021. European Journal of Clinical Microbiology & Infectious Diseases. 1235 - 1243. 6. 40. 2021. . 10.1007/s10096-021-04157-x . European Journal of Clinical Microbiology & Infectious Diseases

Clustering of adenosine A 2B receptors with ectonucleotidases in caveolin-rich lipid rafts underlies immunomodulation by Leishmania amazonensis

Figueiredo, Amanda Braga; Oliveira e Castro, Renata Alves; Nogueira-Paiva, Nívia Carolina; Moreira, Filipa; Gonçalves, Francisco Queiroz; Soares, Rodrigo Pedro; Castro-Borges, William; et al, 2021. The FASEB Journal. 5. 35. 2021. . 10.1096/fj.202002396rr . The FASEB Journal

Electrospun composite fibers of PLA/PLGA blends and mesoporous silica nanoparticles for the controlled release of gentamicin sulfate

Batista, Henrique; Freitas, João P.; Abrunheiro, Alexandra; Gonçalves, Teresa; Gil, Maria H.; Figueiredo, Margarida; Coimbra, Patrícia, 2021. International Journal of Polymeric Materials and Polymeric Biomaterials. 1 - 13. 2021. . 10.1080/00914037.2021.1876053 . International Journal of Polymeric Materials and Polymeric Biomaterials

The transcription factor Ndt80 is a repressor of Candida parapsilosis virulence attributes

Branco, Joana; Martins-Cruz, Cláudia; Rodrigues, Lisa; Silva, Raquel M.; Araújo-Gomes, Nuno; Gonçalves, Teresa; Miranda, Isabel M.; Rodrigues, Acácio G., 2021. Virulence. 601 - 614. 1. 12. 2021. . 10.1080/21505594.2021.1878743 . Virulence

Pyomelanin Synthesis in Alternaria alternata Inhibits DHN-Melanin Synthesis and Decreases Cell Wall Chitin Content and Thickness

Fernandes, Chantal; Mota, Marta; Barros, Lillian; Dias, Maria Inês; Ferreira, Isabel C. F. R.; Piedade, Ana P.; Casadevall, Arturo; Gonçalves, Teresa, 2021. Frontiers in Microbiology. 12. 2021. . 10.3389/fmicb.2021.691433 . Frontiers in Microbiology

Candida Extracellular Nucleotide Metabolism Promotes Neutrophils Extracellular Traps Escape

Afonso, Mariana; Mestre, Ana Rita; Silva, Guilherme; Almeida, Ana Catarina; Cunha, Rodrigo A.; Meyer-Fernandes, José Roberto; Gonçalves, Teresa; Rodrigues, Lisa, 2021. Frontiers in Cellular and Infection Microbiology. 11. 2021. . 10.3389/fcimb.2021.678568 . published Frontiers in Cellular and Infection Microbiology

Identification of Fungi Involved in Onychomycosis in Patients of a Spanish Rural Area

Marcos-Tejedor, Felix; Mota, Marta; Iglesias-Sánchez, María José; Mayordomo, Raquel; Gonçalves, Teresa, 2021. Journal of Fungi. 8. 7. 2021. . 10.3390/jof7080623 . Journal of Fungi

Evaluation of overtime phenotypic variation of yeasts in chronic vulvovaginal candidosis cases

Faria-Gonçalves, Paula; Gaspar, Carlos; Oliveira, Ana Sofia; Palmeira-de-Oliveira, Rita; Gonçalves, Teresa; Martinez-de-Oliveira, José; Palmeira-de-Oliveira, Ana; Rolo, Joana, 2021. Medical Mycology. 2021. . 10.1093/mmy/myab048 . Medical Mycology

Evaluation of a novel dog animal model for peri-implant disease: clinical, radiographic, microbiological and histological assessment

Martins, Orlando; Ramos, João Carlos; Mota, Marta; Dard, Michel; Viegas, Carlos; Caramelo, Francisco; Nogueira, Célia; Gonçalves, Teresa; Baptista, Isabel Poiares, 2020. Clinical Oral Investigations. 3121 - 3132. 9. 24. 2020. . 10.1007/s00784-019-03186-3 . Clinical Oral Investigations

Synthesis, Characterization and Evaluation of the Antibacterial and Antitumor Activity of HalogenatedSalen Copper (II) Complexes derived from Camphoric Acid

Pires, Ana Salomé; Batista, João; Murtinho, Dina; Nogueira, Célia; Karamysheva, Anna; Luísa Ramos, M.; Milne, Bruce F.; et al, 2020. Applied Organometallic Chemistry. 5. 34. 2020. . 10.1002/aoc.5569 . Applied Organometallic Chemistry

Recurrent vulvovaginal Candida spp isolates phenotypically express less virulence traits

Faria-Gonçalves, Paula; Rolo, Joana; Gaspar, Carlos; Oliveira, Ana Sofia; Pestana, Paula Gouveia; Palmeira-de-Oliveira, Rita; Gonçalves, Teresa; Martinez-de-Oliveira, José; Palmeira-de-Oliveira, Ana, 2020. Microbial Pathogenesis. 148. 2020. . 10.1016/j.micpath.2020.104471 . Microbial Pathogenesis

Airborne route and bad use of ventilation systems as non-negligible factors in SARS-CoV-2 transmission

Correia, G.; Rodrigues, L.; Gameiro da Silva, M.; Gonçalves, T., 2020. Medical Hypotheses. 141. 2020. . 10.1016/j.mehy.2020.109781 . Medical Hypotheses

Preparation of gentamicin sulfate eluting fiber mats by emulsion and by suspension electrospinning

Coimbra, Patrícia; Freitas, João P.; Gonçalves, Teresa; Gil, Maria H.; Figueiredo, Margarida, 2019. Materials Science and Engineering: C. 86 - 93. 94. 2019. . 10.1016/j.msec.2018.09.019 . Materials Science and Engineering: C

An Insight into Advanced Approaches for Photosensitizer Optimization in Endodontics—A Critical Review

Diogo, Patrícia; F. Faustino, M. Amparo; P. M. S. Neves, M. Graça; Palma, Paulo J.; P. Baptista, Isabel; Gonçalves, Teresa; Santos, João Miguel, 2019. Journal of Functional Biomaterials. 4. 10. 2019. . 10.3390/jfb10040044 . Journal of Functional Biomaterials

Chitosan Plus Compound 48/80: Formulation and Preliminary Evaluation as a Hepatitis B Vaccine Adjuvant

Bento, Dulce; Jesus, Sandra; Lebre, Filipa; Gonçalves, Teresa; Borges, Olga, 2019. Pharmaceutics. 2. 11. 2019. . 10.3390/pharmaceutics11020072 . Pharmaceutics

Early Interaction of Alternaria infectoria Conidia with Macrophages

Almeida, M. C.; Antunes, D.; Silva, B. M. A.; Rodrigues, L.; Mota, M.; Borges, O.; Fernandes, C.; Gonçalves, T., 2019. Mycopathologia. 383 - 392. 3. 184. 2019. . 10.1007/s11046-019-00339-6 . Mycopathologia

The antifungal activity of extracts of Osmundea pinnatifida, an edible seaweed, indicates its usage as a safe environmental fungicide or as a food additive preventing post-harvest fungal food contamination

Silva, Paulo; Fernandes, Chantal; Barros, Lillian; Ferreira, Isabel C. F. R.; Pereira, Leonel; Gonçalves, Teresa, 2018. Food & Function. 6187 - 6195. 12. 9. 2018. . 10.1039/c8fo01797b . Food & Function

Is the chlorophyll derivative Zn(II)e 6 Me a good photosensitizer to be used in root canal disinfection?

Diogo, Patrícia; Mota, Marta; Fernandes, Chantal; Sequeira, Diana; Palma, Paulo; Caramelo, Francisco; Neves, M. Graça P.M.S.; et al, 2018. Photodiagnosis and Photodynamic Therapy. 205 - 211. 22. 2018. . 10.1016/j.pdpdt.2018.04.009 . published Photodiagnosis and Photodynamic Therapy

Intestinal Microbial and Metabolic Profiling of Mice Fed with High-Glucose and High-Fructose Diets

Silva, João C. P.; Mota, Marta; Martins, Fátima O.; Nogueira, Célia; Gonçalves, Teresa; Carneiro, Tatiana; Pinto, Joana; et al, 2018. Journal of Proteome Research. 2880 - 2891. 8. 17. 2018. . 10.1021/acs.jproteome.8b00354 . Journal of Proteome Research

Antimicrobial Photodynamic Therapy against Endodontic Enterococcus faecalis and Candida albicans Mono and Mixed Biofilms in the Presence of Photosensitizers: A Comparative Study with Classical Endodontic Irrigants

Diogo, Patrícia; Fernandes, Chantal; Caramelo, Francisco; Mota, Marta; Miranda, Isabel M.; Faustino, M. A. F.; Neves, M. G. P. M. S.; et al, 2017. Frontiers in Microbiology. 8. 2017. . 10.3389/fmicb.2017.00498 . Frontiers in Microbiology

Type 1 diabetes in children is not a predisposing factor for oral yeast colonization.

Costa AL; Silva BM; Soares R; Mota D; Alves V; Mirante A; Ramos JC; et al, 2016. 2016. .

Antifungal activity of carrageenan extracts from the red alga Chondracanthus teedei var. lusitanicus

Soares, Fabiana; Fernandes, Chantal; Silva, Paulo; Pereira, Leonel; Gonçalves, Teresa, 2016. Journal of Applied Phycology. 2991 - 2998. 5. 28. 2016. . 10.1007/s10811-016-0849-9 . Journal of Applied Phycology

Type 1 diabetes in children is not a predisposing factor for oral yeast colonization

Costa, Ana L.; Silva, Branca M.A.; Soares, Rui; Mota, Diana; Alves, Vera; Mirante, Alice; Ramos, João C.; et al, 2016. Medical Mycology. 2016. . 10.1093/mmy/myw092 . Medical Mycology

The importance of subclasses of chitin synthase enzymes with myosin-like domains for the fitness of fungi

Fernandes, Chantal; Gow, Neil A.R.; Gonçalves, Teresa, 2016. Fungal Biology Reviews. 1 - 14. 1. 30. 2016. . 10.1016/j.fbr.2016.03.002 . Fungal Biology Reviews

Blunted dynamics of adenosine A2A receptors is associated with increased susceptibility to Candida albicans infection in the elderly

Rodrigues, Lisa; Miranda, Isabel M.; Andrade, Geanne M.; Mota, Marta; Cortes, Luísa; Rodrigues, Acácio G.; Cunha, Rodrigo A.; Gonçalves, Teresa, 2016. Oncotarget. 62862 - 62872. 39. 7. 2016. . 10.18632/oncotarget.11760 . Oncotarget

Activation of Melanin Synthesis in Alternaria infectoria by Antifungal Drugs

Fernandes, Chantal; Prados-Rosales, Rafael; Silva, Branca M. A.; Nakouzi-Naranjo, Antonio; Zuzarte, Mónica; Chatterjee, Subhasish; Stark, Ruth E.; Casadevall, Arturo; Gonçalves, Teresa, 2016. Antimicrobial Agents and Chemotherapy. 1646 - 1655. 3. 60. 2016. . 10.1128/aac.02190-15 . Antimicrobial Agents and Chemotherapy

HIV1-viral protein R (Vpr) mutations: associated phenotypes and relevance for clinical pathologies

Soares, Rui; Rocha, Graça; Meliço-Silvestre, António; Gonçalves, Teresa, 2016. Reviews in Medical Virology. 314 - 329. 5. 26. 2016. . 10.1002/rmv.1889 . Reviews in Medical Virology

Characterization of extracellular nucleotide metabolism inCandida albicans

Rodrigues, Lisa; Russo-Abrahão, Thais; Cunha, Rodrigo A.; Gonçalves, Teresa; Meyer-Fernandes, José Roberto, 2015. FEMS Microbiology Letters. 1. 363. 2015. . 10.1093/femsle/fnv212 . FEMS Microbiology Letters

Different danger signals differently impact on microglial proliferation through alterations of ATP release and extracellular metabolism

George, Jimmy; Gonçalves, Francisco Q.; Cristóvão, Gonçalo; Rodrigues, Lisa; Meyer Fernandes, José Roberto; Gonçalves, Teresa; Cunha, Rodrigo A.; Gomes, Catarina A., 2015. Glia. 1636 - 1645. 9. 63. 2015. . 10.1002/glia.22833 . Glia

Development of a novel adjuvanted nasal vaccine: C48/80 associated with chitosan nanoparticles as a path to enhance mucosal immunity

Bento, D.; Staats, H.F.; Gonçalves, T.; Borges, O., 2015. European Journal of Pharmaceutics and Biopharmaceutics. 149 - 164. 93. 2015. . 10.1016/j.ejpb.2015.03.024 . European Journal of Pharmaceutics and Biopharmaceutics

Macrophage Mitochondrial and Stress Response to Ingestion ofCryptococcus neoformans

Coelho, Carolina; Souza, Ana Camila Oliveira; Derengowski, Lorena da Silveira; de Leon-Rodriguez, Carlos; Wang, Bo; Leon-Rivera, Rosiris; Bocca, Anamelia Lorenzetti; Gonçalves, Teresa; Casadevall, Arturo, 2015. The Journal of Immunology. 2345 - 2357. 5. 194. 2015. . 10.4049/jimmunol.1402350 . The Journal of Immunology

Photodynamic Antimicrobial Chemotherapy for Root Canal System Asepsis: A Narrative Literature Review

Diogo, P.; Gonçalves, T.; Palma, P.; Santos, J. M., 2015. International Journal of Dentistry. 1 - 26. 2015. 2015. . 10.1155/2015/269205 . International Journal of Dentistry

Modulation of Alternaria infectoria Cell Wall Chitin and Glucan Synthesis by Cell Wall Synthase Inhibitors

Fernandes, C.; Anjos, J.; Walker, L. A.; Silva, B. M. A.; Cortes, L.; Mota, M.; Munro, C. A.; Gow, N. A. R.; Goncalves, T., 2014. Antimicrobial Agents and Chemotherapy. 2894 - 2904. 5. 58. 2014. . 10.1128/aac.02647-13 . Antimicrobial Agents and Chemotherapy

Modulation of alternaria infectoria cell wall chitin and glucan synthesis by cell wall synthase inhibitors

Fernandes, C.; Anjos, J.; Walker, L.A.; Silva, B.M.A.; Cortes, L.; Mota, M.; Munro, C.A.; Gow, N.A.R.; Gonçalvesa, T., 2014. Antimicrobial Agents and Chemotherapy. 2894 - 2904. 5. 58. 2014. . 10.1128/AAC.02647-13 . Antimicrobial Agents and Chemotherapy

Modulation of Alternaria infectoria cell wall chitin and glucan synthesis by cell wall synthase inhibitors.

Fernandes C; Anjos J; Walker LA; Silva BM; Cortes L; Mota M; Munro CA; Gow NA; Gonçalves T, 2014. 2014. .

Characterization of Alternaria infectoria extracellular vesicles

Silva, B. M. A.; Prados-Rosales, R.; Espadas-Moreno, J.; Wolf, J. M.; Luque-Garcia, J. L.; Goncalves, T.; Casadevall, A., 2013. Medical Mycology. 202 - 210. 2. 52. 2013. . 10.1093/mmy/myt003 . Medical Mycology

Candida albicans CUG Mistranslation Is a Mechanism To Create Cell Surface Variation

Miranda, Isabel; Silva-Dias, Ana; Rocha, Rita; Teixeira-Santos, Rita; Coelho, Carolina; Gonçalves, Teresa; Santos, Manuel A. S.; et al, 2013. mBio. 4. 4. 2013. . 10.1128/mbio.00285-13 . mBio

Validation of a New 96-Well Plate Spectrophotometric Method for the Quantification of Compound 48/80 Associated with Particles

Bento, Dulce; Borchard, Gerrit; Gonçalves, Teresa; Borges, Olga, 2013. AAPS PharmSciTech. 649 - 655. 2. 14. 2013. . 10.1208/s12249-013-9950-4 . AAPS PharmSciTech

ß(1,3)-glucan synthase complex from Alternaria infectoria, a rare dematiaceous human pathogen

Anjos, Jorge; Fernandes, Chantal; Silva, Branca M. A.; Quintas, Célia; Abrunheiro, Alexandra; Gow, Neil A. R.; Gonçalves, Teresa, 2012. Medical Mycology. 716 - 725. 7. 50. 2012. . 10.3109/13693786.2012.675525 . Medical Mycology

Microbial quality and yeast population dynamics in cracked green table olives’ fermentations

Alves, Maria; Gonçalves, Teresa; Quintas, Célia, 2012. Food Control. 363 - 368. 2. 23. 2012. . 10.1016/j.foodcont.2011.07.033 . Food Control

Analysis of Cell Cycle and Replication of Mouse Macrophages after In Vivo and In Vitro Cryptococcus neoformans Infection Using Laser Scanning Cytometry

Coelho, Carolina; Tesfa, Lydia; Zhang, Jinghang; Rivera, Johanna; Gonçalves, Teresa; Casadevall, Arturo, 2012. Infection and Immunity. 1467 - 1478. 4. 80. 2012. . 10.1128/iai.06332-11 . Infection and Immunity

Yeast diversity in the Mediterranean strawberry tree (Arbutus unedo L.) fruits' fermentations

Santo, David Espírito; Galego, Ludovina; Gonçalves, Teresa; Quintas, Célia, 2012. Food Research International. 45 - 50. 1. 47. 2012. . 10.1016/j.foodres.2012.01.009 . Food Research International

Candida krusei reservoir in a neutropaenia unit: molecular evidence of a foe?

Ricardo, E.; Silva, A.P.; Gonçalves, T.; de Oliveira, S. Costa; Granato, C.; Martins, J.; Rodrigues, A.G.; Pina-Vaz, C., 2011. Clinical Microbiology and Infection. 259 - 263. 2. 17. 2011. . 10.1111/j.1469-0691.2010.03223.x . Clinical Microbiology and Infection

Evaluation of Helicobacter pylori eradication by triple therapy plus Lactobacillus acidophilus compared to triple therapy alone

Silva Medeiros, J. A.; F. O. Gonçalves, T. M.; Boyanova, L.; Correia Pereira, M. I.; Silva Paiva de Carvalho, J. N.; Sousa Pereira, A. M.; Silvério Cabrita, A. M., 2011. European Journal of Clinical Microbiology & Infectious Diseases. 555 - 559. 4. 30. 2011. . 10.1007/s10096-010-1119-4 . European Journal of Clinical Microbiology & Infectious Diseases

Retrospective analysis of clinical yeast isolates in a hospital in the centre of Portugal: spectrum and revision of the identification procedures

Paulo, Cristina; Mourão, Cristina; Veiga, Pedro M.; Marques, Joana M.; Rocha, Graça; Alves, Ana F.; Querol, Amparo; et al, 2009. Medical Mycology. 836 - 844. 8. 47. 2009. . 10.3109/13693780802709081 . Medical Mycology

Alternaria infectoria brain abscess in a child with chronic granulomatous disease

Hipolito, E.; Faria, E.; Alves, A. F.; Hoog, G. S.; Anjos, J.; Gonçalves, T.; Morais, P. V.; Estevão, H., 2008. European Journal of Clinical Microbiology & Infectious Diseases. 377 - 380. 4. 28. 2008. . 10.1007/s10096-008-0623-2 . European Journal of Clinical Microbiology & Infectious Diseases

Saccharomyces cerevisiae Hog1 Protein Phosphorylation upon Exposure to Bacterial Endotoxin

Marques, Joana M.; Rodrigues, Ricardo J.; de Magalhães-Sant'Ana, Augusto C.; Gonçalves, Teresa, 2006. Journal of Biological Chemistry. 24687 - 24694. 34. 281. 2006. . 10.1074/jbc.m603753200 . Journal of Biological Chemistry

Expression of HPV16 E6 oncoprotein increases resistance to several stress conditions in

PINTODEOLIVEIRA, A; MCCANCE, D; DEMAGALHAESSANTANA, A; MARQUES, J; GONCALVES, T, 2005. FEMS Yeast Research. 777 - 787. 8. 5. 2005. . 10.1016/j.femsyr.2005.02.002 . FEMS Yeast Research

Evidence for involvement of Saccharomyces cerevisiae protein kinase C in glucose induction of HXT genes and derepression of SUC2

Brandao, RL; Etchebehere, L; Queiroz, CC; Tropia, MJ; Ernandes, JR; Goncalves, T; Loureiro-Dias, MC; et al, 2002. Fems Yeast Research. 93 - 102. 2. 2. 2002. . 10.1111/j.1567-1364.2002.tb00074.x . Fems Yeast Research

The lag phase rather than the exponential-growth phase on glucose is associated with a higher cAMP level in wild-type and cAPK-attenuated strains of the yeast Saccharomyces cerevisiae

Ma, P.; Gonçalves, T.; Maretzek, A.; Dias, M.C.L.; Thevelein, J.M., 1997. Microbiology. 3451 - 3459. 11. 143. 1997. . 10.1099/00221287-143-11-3451 . Microbiology

Kinetics and regulation of fructose and glucose transport systems are responsible for fructophily in Zygosaccharomyces bailii

Sousa-Dias, S.; Gonçalves, T.; Leyva, J.S.; Peinado, J.M.; Loureiro-Dias, M.C., 1996. Microbiology. 1733 - 1738. 7. 142. 1996. . 10.1099/13500872-142-7-1733 . Microbiology

Aspects of glucose uptake in Saccharomyces cerevisiae

Goncalves, T.; Loureiro-Dias, M.C., 1994. Journal of Bacteriology. 1511 - 1513. 5. 176. 1994. . Journal of Bacteriology


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