Publications
Information about journal articles, updated at 15-12-2024, from platform CIÊNCIAVITAE.
Neurovascular dysfunction in psychiatric disorders: Underlying mechanisms and therapeutic approaches
Eliane Swely Sanches; Daniela Simões; Filipa Isabel Baptista; Ana Paula Silva, European Journal of Clinical Investigation. 2025. https://doi.org/10.1111/eci.14319 . 10.1111/eci.14319 . published European Journal of Clinical Investigation
ENPP1 induces blood-brain barrier dysfunction and promotes brain metastasis formation in HER2-positive breast cancer
Santos, Liliana; Tomatis, Francesca; Ferreira, Hugo R S; Almeida, Sara F F; Ciputra, Edward; Sereno, José; Almeida, Rui; et al, Neuro-Oncology. 2024. https://doi.org/10.1093/neuonc/noae169 . 10.1093/neuonc/noae169 . Neuro-Oncology
Deciphering the impact of cancer cell´s secretome and its derived-peptide VGF on breast cancer brain metastasis (2024)
Rita Carvalho; Liliana Santos; Inês Conde; Ricardo Leitão; Hugo R.S. Ferreira; Célia Gomes; Silva, Ana Paula; et al, 2024. https://www.biorxiv.org/content/biorxiv/early/2024/02/25/2024.02.22.581537.full.pdf . under revision
Dichotomous effect of methylphenidate on microglia and astrocytes: Insights from in vitro and animal studies
Novo, João P.; Muga, Mariana; Lourenço, Teresa; Sanches, Eliane S.; Leitão, Ricardo A.; Silva, Ana Paula, Toxicology Letters. 1 - 10. 389. 2023. http://dx.doi.org/10.1016/j.toxlet.2023.10.008 . 10.1016/j.toxlet.2023.10.008 . published Toxicology Letters
Attention-Deficit/Hyperactivity Disorder Animal Model Presents Retinal Alterations and Methylphenidate Has a Differential Effect in ADHD versus Control Conditions
Sanches, Eliane S.; Boia, Raquel; Leitão, Ricardo A.; Madeira, Maria H.; Fontes-Ribeiro, Carlos A.; Ambrósio, António Francisco; Fernandes, Rosa; Silva, Ana Paula, Antioxidants. 4. 12. 2023. http://dx.doi.org/10.3390/antiox12040937 . 10.3390/antiox12040937 . published Antioxidants
ApoE Mimetic Peptides to Improve the Vicious Cycle of Malnutrition and Enteric Infections by Targeting the Intestinal and Blood-Brain Barriers
Reinaldo B. Oriá; Raul S. Freitas; Cássia R. Roque; José Carlos R. Nascimento; Ana Paula P. S. Martins; João O. Malva; Richard L. Guerrant; Michael P. Vitek, Pharmaceutics. 2023. https://doi.org/10.3390/pharmaceutics15041086 . 10.3390/pharmaceutics15041086 . Pharmaceutics
The effect of parthenolide on methamphetamine-induced blood-brain barrier and astrocyte alterations
Ricardo A. Leitão; Carlos A. Fontes-Ribeiro; Ana Paula Silva, European Journal of Clinical Investigation. 2022. https://doi.org/10.1111/eci.13694 . 10.1111/eci.13694 . European Journal of Clinical Investigation
Metaplastic contribution of neuropeptide Y receptors to spatial memory acquisition
Méndez-Couz, Marta; Manahan-Vaughan, Denise; Silva, Ana Paula; González-Pardo, Héctor; Arias, Jorge Luis; Conejo, Nélida María, Behavioural Brain Research. 396. 2021. http://dx.doi.org/10.1016/j.bbr.2020.112864 . 10.1016/j.bbr.2020.112864 . published Behavioural Brain Research
Protective effect of neuropeptide Y2 receptor activation against methamphetamine-induced brain endothelial cell alterations
Ventura, Fabiana; Muga, Mariana; Coelho-Santos, Vanessa; Fontes-Ribeiro, Carlos A.; Leitão, Ricardo A.; Silva, Ana Paula, Toxicology Letters. 53 - 59. 334. 2020. http://dx.doi.org/10.1016/j.toxlet.2020.09.013 . 10.1016/j.toxlet.2020.09.013 . published Toxicology Letters
A multi-staged neuropeptide response to traumatic brain injury
Alves, José Luís; Mendes, João; Leitão, Ricardo; Silva, Ana Paula; Pinto, Anabela Mota, European Journal of Trauma and Emergency Surgery. 2020. http://dx.doi.org/10.1007/s00068-020-01431-z . 10.1007/s00068-020-01431-z . published European Journal of Trauma and Emergency Surgery
Microglia Dysfunction Caused by the Loss of Rhoa Disrupts Neuronal Physiology and Leads to Neurodegeneration
Socodato, Renato; Portugal, Camila C.; Canedo, Teresa; Rodrigues, Artur; Almeida, Tiago O.; Henriques, Joana F.; Vaz, Sandra H.; et al, Cell Reports. 12. 31. 2020. http://dx.doi.org/10.1016/j.celrep.2020.107796 . 10.1016/j.celrep.2020.107796 . published Cell Reports
Effect of Hypoproteic and High-Fat Diets on Hippocampal Blood-Brain Barrier Permeability and Oxidative Stress
de Aquino, Cristhyane Costa; Leitão, Ricardo A.; Oliveira Alves, Luís A.; Coelho-Santos, Vanessa; Guerrant, Richard L.; Ribeiro, Carlos F.; Malva, João O.; Silva, Ana P.; Oriá, Reinaldo B., Frontiers in Nutrition. 5. 2019. http://dx.doi.org/10.3389/fnut.2018.00131 . 10.3389/fnut.2018.00131 . published Frontiers in Nutrition
The interplay between glioblastoma and microglia cells leads to endothelial cell monolayer dysfunction via the interleukin-6-induced JAK2/STAT3 pathway
Couto, Marina; Coelho-Santos, Vanessa; Santos, Liliana; Fontes-Ribeiro, Carlos; Silva, Ana Paula; Gomes, Célia M. F., Journal of Cellular Physiology. 19750 - 19760. 11. 234. 2019. http://dx.doi.org/10.1002/jcp.28575 . 10.1002/jcp.28575 . published Journal of Cellular Physiology
The dipeptidyl peptidase-4 (DPP-4) inhibitor sitagliptin ameliorates retinal endothelial cell dysfunction triggered by inflammation
Gonçalves, Andreia; Almeida, Luísa; Silva, Ana Paula; Fontes-Ribeiro, Carlos; Ambrósio, António F.; Cristóvão, Armando; Fernandes, Rosa, Biomedicine & Pharmacotherapy. 833 - 838. 102. 2018. http://dx.doi.org/10.1016/j.biopha.2018.03.144 . 10.1016/j.biopha.2018.03.144 . accepted Biomedicine & Pharmacotherapy
Effect of chronic methylphenidate treatment on hippocampal neurovascular unit and memory performance in late adolescent rats
Coelho-Santos, Vanessa; Cardoso, Filipa L.; Magalhães, Ana; Ferreira-Teixeira, Margarida; Leitão, Ricardo A.; Gomes, Célia; Rito, Manuel; et al, European Neuropsychopharmacology. 195 - 210. 2. 29. 2018. http://dx.doi.org/10.1016/j.euroneuro.2018.12.007 . 10.1016/j.euroneuro.2018.12.007 . published European Neuropsychopharmacology
Aquaporin-4 as a New Target against Methamphetamine-Induced Brain Alterations: Focus on the Neurogliovascular Unit and Motivational Behavior
Leitão, Ricardo Alexandre; Sereno, José; Castelhano, João Miguel; Gonçalves, Sónia Isabel; Coelho-Santos, Vanessa; Fontes-Ribeiro, Carlos; Castelo-Branco, Miguel; Silva, Ana Paula, Molecular Neurobiology. 2056 - 2069. 3. 55. 2017. http://dx.doi.org/10.1007/s12035-017-0439-0 . 10.1007/s12035-017-0439-0 . published Molecular Neurobiology
Extended-access methamphetamine self-administration elicits neuroinflammatory response along with blood-brain barrier breakdown.
Gonçalves J; Leitão RA; Higuera-Matas A; Assis MA; Coria SM; Fontes-Ribeiro C; Ambrosio E; Silva AP, 2017. http://europepmc.org/abstract/med/28237710 . 10.1016/j.bbi.2017.02.017 .
Impact of developmental exposure to methylphenidate on rat brain's immune privilege and behavior: Control versus ADHD model.
Silva, Ana Paula, Brain, behavior, and immunity. 2017. http://europepmc.org/abstract/med/29061363 . 10.1016/j.bbi.2017.10.016 . Brain, behavior, and immunity
Exosomes secreted by cardiomyocytes subjected to ischaemia promote cardiac angiogenesis
Ribeiro-Rodrigues, Teresa M.; Laundos, Tiago L.; Pereira-Carvalho, Rita; Batista-Almeida, Daniela; Pereira, Ricardo; Coelho-Santos, Vanessa; Silva, Ana P.; et al, Cardiovascular Research. 1338 - 1350. 11. 113. 2017. http://dx.doi.org/10.1093/cvr/cvx118 . 10.1093/cvr/cvx118 . Cardiovascular Research
Impact of Neuroinflammation on Hippocampal Neurogenesis: Relevance to Aging and Alzheimer´s Disease
Valero, Jorge; Bernardino, Liliana; Cardoso, Filipa Lourenço; Silva, Ana Paula; Fontes-Ribeiro, Carlos; Ambrósio, António Francisco; Malva, João Oliveira, Journal of Alzheimer's Disease. S161 - S168. s1. 60. 2017. http://dx.doi.org/10.3233/jad-170239 . 10.3233/jad-170239 . published Journal of Alzheimer's Disease
Testing the excitation/inhibition imbalance hypothesis in a mouse model of the autism spectrum disorder: in vivo neurospectroscopy and molecular evidence for regional phenotypes
Gonçalves, Joana; Violante, Inês R.; Sereno, José; Leitão, Ricardo A.; Cai, Ying; Abrunhosa, Antero; Silva, Ana Paula; Silva, Alcino J.; Castelo-Branco, Miguel, Molecular Autism. 1. 8. 2017. http://dx.doi.org/10.1186/s13229-017-0166-4 . 10.1186/s13229-017-0166-4 . published Molecular Autism
Methylphenidate-triggered ROS generation promotes caveolae-mediated transcytosis via Rac1 signaling and c-Src-dependent caveolin-1 phosphorylation in human brain endothelial cells.
Coelho-Santos V; Socodato R; Portugal C; Leitão RA; Rito M; Barbosa M; Couraud PO; et al, 2016. http://europepmc.org/abstract/med/27376435 .
Long-Term Treatment with Low Doses of Methamphetamine Promotes Neuronal Differentiation and Strengthens Long-Term Potentiation of Glutamatergic Synapses onto Dentate Granule Neurons
Baptista, Sofia; Lourenço, Joana; Milhazes, Nuno; Borges, Fernanda; Silva, Ana Paula; Bacci, Alberto, eneuro. ENEURO.0141 - 16.2016. 3. 3. 2016. http://dx.doi.org/10.1523/eneuro.0141-16.2016 . 10.1523/eneuro.0141-16.2016 . published eneuro
The TNF-alpha/NF-kB Signaling Pathway has a Key Role in Methamphetamine-Induced Blood-Brain Barrier Dysfunction
Coelho-Santos, Vanessa; Leitão, Ricardo A; Cardoso, Filipa L; Palmela, Inês; Rito, Manuel; Barbosa, Marcos; Brito, Maria A; Fontes-Ribeiro, Carlos A; Silva, Ana P, Journal of Cerebral Blood Flow & Metabolism. 1260 - 1271. 8. 35. 2015. http://dx.doi.org/10.1038/jcbfm.2015.59 . 10.1038/jcbfm.2015.59 . published Journal of Cerebral Blood Flow & Metabolism
Psychostimulants and brain edema
Leitão, Ricardo Alexandre; Silva, Ana Paula, Research & Networks in Health. 1. 1. 2015. https://journals.ipleiria.pt/index.php/rnhealth/article/view/60 . published Research & Networks in Health
Effects of drugs of abuse on the central neuropeptide Y system
Gonçalves, Joana; Martins, João; Baptista, Sofia; Ambrósio, António Francisco; Silva, Ana Paula, Addiction Biology. 755 - 765. 4. 21. 2015. http://dx.doi.org/10.1111/adb.12250 . 10.1111/adb.12250 . published Addiction Biology
Effects of drugs of abuse on the central neuropeptide Y system.
Gonçalves J; Martins J; Baptista S; Ambrósio AF; Silva AP, 2015. http://europepmc.org/abstract/med/25904345 .
Methamphetamine decreases dentate gyrus stem cell self-renewal and shifts the differentiation towards neuronal fate
Baptista, Sofia; Lasgi, Charlène; Benstaali, Caroline; Milhazes, Nuno; Borges, Fernanda; Fontes-Ribeiro, Carlos; Agasse, Fabienne; Silva, Ana Paula, Stem Cell Research. 329 - 341. 2. 13. 2014. http://dx.doi.org/10.1016/j.scr.2014.08.003 . 10.1016/j.scr.2014.08.003 . Stem Cell Research
Psychostimulants and brain dysfunction: A review of the relevant neurotoxic effects
Gonçalves, Joana; Baptista, Sofia; Silva, Ana Paula, Neuropharmacology. 135 - 149. 87. 2014. http://dx.doi.org/10.1016/j.neuropharm.2014.01.006 . 10.1016/j.neuropharm.2014.01.006 . published Neuropharmacology
Erratum to: Role of Methamphetamine on Glioblastoma Cytotoxicity Induced by Doxorubicin and Methotrexate.
Capelôa T; Caramelo F; Fontes-Ribeiro C; Gomes C; Silva AP, 2014. http://europepmc.org/abstract/med/24788666 . 10.1007/s12640-014-9471-2 .
Role of Methamphetamine on Glioblastoma Cytotoxicity Induced by Doxorubicin and Methotrexate
Capelôa, Tânia; Caramelo, Francisco; Fontes-Ribeiro, Carlos; Gomes, Célia; Silva, Ana P., Neurotoxicity Research. 216 - 227. 3. 26. 2014. http://dx.doi.org/10.1007/s12640-014-9464-1 . 10.1007/s12640-014-9464-1 . published Neurotoxicity Research
Acetyl-L-Carnitine Prevents Methamphetamine-Induced Structural Damage on Endothelial Cells via ILK-Related MMP-9 Activity
Fernandes, S.; Salta, S.; Bravo, J.; Silva, A. P.; Summavielle, T., Molecular Neurobiology. 408 - 422. 1. 53. 2014. http://dx.doi.org/10.1007/s12035-014-8973-5 . 10.1007/s12035-014-8973-5 . Molecular Neurobiology
Methamphetamine-induced nitric oxide promotes vesicular transport in blood-brain barrier endothelial cells
Martins, Tânia; Burgoyne, Thomas; Kenny, Bridget-Ann; Hudson, Natalie; Futter, Clare E.; Ambrósio, António F.; Silva, Ana P.; Greenwood, John; Turowski, Patric, Neuropharmacology. 74 - 82. 65. 2013. http://dx.doi.org/10.1016/j.neuropharm.2012.08.021 . 10.1016/j.neuropharm.2012.08.021 . published Neuropharmacology
Multifaces of neuropeptide Y in the brain: Neuroprotection, neurogenesis and neuroinflammation
Malva, J.O.; Xapelli, S.; Baptista, S.; Valero, J.; Agasse, F.; Ferreira, R.; Silva, A.P., Neuropeptides. 299 - 308. 6. 46. 2012. http://dx.doi.org/10.1016/j.npep.2012.09.001 . 10.1016/j.npep.2012.09.001 . published Neuropeptides
Methamphetamine-induced changes in the mice hippocampal neuropeptide Y system: implications for memory impairment
Gonçalves, Joana; Baptista, Sofia; Olesen, Mikkel V.; Fontes-Ribeiro, Carlos; Malva, João O.; Woldbye, David P.; Silva, Ana P., Journal of Neurochemistry. 1041 - 1053. 6. 123. 2012. http://dx.doi.org/10.1111/jnc.12052 . 10.1111/jnc.12052 . published Journal of Neurochemistry
Neuropeptide Y promotes neurogenesis and protection against methamphetamine-induced toxicity in mouse dentate gyrus-derived neurosphere cultures
Baptista, Sofia; Bento, Ana Rita; Gonçalves, Joana; Bernardino, Liliana; Summavielle, Teresa; Lobo, Andrea; Fontes-Ribeiro, Carlos; et al, Neuropharmacology. 2413 - 2423. 7. 62. 2012. http://dx.doi.org/10.1016/j.neuropharm.2012.02.015 . 10.1016/j.neuropharm.2012.02.015 . published Neuropharmacology
Prevention of methamphetamine-induced microglial cell death by TNF-a and IL-6 through activation of the JAK-STAT pathway
Coelho-Santos, Vanessa; Gonçalves, Joana; Fontes-Ribeiro, Carlos; Silva, Ana Paula, Journal of Neuroinflammation. 1. 9. 2012. http://dx.doi.org/10.1186/1742-2094-9-103 . 10.1186/1742-2094-9-103 . published Journal of Neuroinflammation
Protective role of neuropeptide Y Y2receptors in cell death and microglial response following methamphetamine injury
Gonçalves, Joana; Ribeiro, Carlos F.; Malva, João O.; Silva, Ana P., European Journal of Neuroscience. 3173 - 3183. 9. 36. 2012. http://dx.doi.org/10.1111/j.1460-9568.2012.08232.x . 10.1111/j.1460-9568.2012.08232.x . published European Journal of Neuroscience
Neuropeptide Y promotes neurogenesis and protection against methamphetamine-induced toxicity in mouse dentate gyrus-derived neurosphere cultures.
Baptista, S.; Bento, A.R.; Gonçalves, J.; Bernardino, L.; Summavielle, T.; Lobo, A.; Fontes-Ribeiro, C.; et al, Neuropharmacology. 2413 - 2423. 7. 62. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84871869687&partnerID=MN8TOARS . Neuropharmacology
Ampakine CX546 increases proliferation and neuronal differentiation in subventricular zone stem/progenitor cell cultures
Schitine, Clarissa; Xapelli, Sara; Agasse, Fabienne; Sardà-Arroyo, Laura; Silva, Ana P.; De Melo Reis, Ricardo A.; de Mello, Fernando G.; Malva, João O., European Journal of Neuroscience. 1672 - 1683. 11. 35. 2012. http://dx.doi.org/10.1111/j.1460-9568.2012.08072.x . 10.1111/j.1460-9568.2012.08072.x . published European Journal of Neuroscience
Methamphetamine transiently increases the blood-brain barrier permeability in the hippocampus: Role of tight junction proteins and matrix metalloproteinase-9
Martins, Tânia; Baptista, Sofia; Gonçalves, Joana; Leal, Ermelindo; Milhazes, Nuno; Borges, Fernanda; Ribeiro, Carlos F.; et al, Brain Research. 28 - 40. 1411. 2011. http://dx.doi.org/10.1016/j.brainres.2011.07.013 . 10.1016/j.brainres.2011.07.013 . published Brain Research
Metanfetamina e o ciclo do glutamato no cérebro de murganho
Silva, Ana Paula, Revista Toxicodependências. 67 - 76. 2. 17. 2011. published Revista Toxicodependências
Neuropeptide Y inhibits interleukin-1 beta-induced microglia motility
Ferreira, Raquel; Santos, Tiago; Cortes, Luísa; Cochaud, Stéphanie; Agasse, Fabienne; Silva, Ana Paula; Xapelli, Sara; Malva, João O., Journal of Neurochemistry. 93 - 105. 1. 120. 2011. http://dx.doi.org/10.1111/j.1471-4159.2011.07541.x . 10.1111/j.1471-4159.2011.07541.x . published Journal of Neurochemistry
May Exercise Prevent Addiction?
A. Fontes-Ribeiro, C.; Marques, E.; C. Pereira, F.; P. Silva, A.; R. A. Macedo, T., Current Neuropharmacology. 45 - 48. 1. 9. 2011. http://dx.doi.org/10.2174/157015911795017380 . 10.2174/157015911795017380 . published Current Neuropharmacology
Methamphetamine Exerts Toxic Effects on Subventricular Zone Stem/Progenitor Cells and Inhibits Neuronal Differentiation
Bento, Ana Rita; Baptista, Sofia; Malva, João O.; Silva, Ana Paula; Agasse, Fabienne, Rejuvenation Research. 205 - 214. 2. 14. 2011. http://dx.doi.org/10.1089/rej.2010.1109 . 10.1089/rej.2010.1109 . published Rejuvenation Research
Brain injury associated with widely abused amphetamines: neuroinflammation, neurogenesis and blood-brain barrier.
Silva AP; Martins T; Baptista S; Gonçalves J; Agasse F; Malva JO, 2010. http://europepmc.org/abstract/med/21208167 .
Brain Injury Associated With Widely Abused Amphetamines: Neuroinflammation, Neurogenesis And Blood-Brain Barrier
Silva, A.P.; Martins, T.; Baptista, S.; Gonçalves, J.; Agasse, F.; Malva, J.O., Current Drug Abuse Reviews. 239 - 254. 4. 3. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-79551645771&partnerID=MN8TOARS . Current Drug Abuse Reviews
Methamphetamine-induced neuroinflammation and neuronal dysfunction in the mice hippocampus: preventive effect of indomethacin
Gonçalves, Joana; Baptista, Sofia; Martins, Tânia; Milhazes, Nuno; Borges, Fernanda; Ribeiro, Carlos F.; Malva, João O.; Silva, Ana P., European Journal of Neuroscience. 315 - 326. 2. 31. 2010. http://dx.doi.org/10.1111/j.1460-9568.2009.07059.x . 10.1111/j.1460-9568.2009.07059.x . published European Journal of Neuroscience
Neuropeptide Y Modulation of Interleukin-1ß (IL-1ß)-induced Nitric Oxide Production in Microglia
Ferreira, Raquel; Xapelli, Sara; Santos, Tiago; Silva, Ana Paula; Cristóvão, Armando; Cortes, Luísa; Malva, João O., Journal of Biological Chemistry. 41921 - 41934. 53. 285. 2010. http://dx.doi.org/10.1074/jbc.m110.164020 . 10.1074/jbc.m110.164020 . published Journal of Biological Chemistry
Interaction between neuropeptide Y (NPY) and brain-derived neurotrophic factor in NPY-mediated neuroprotection against excitotoxicity: a role for microglia
Xapelli, S.; Bernardino, L.; Ferreira, R.; Grade, S.; Silva, A. P.; Salgado, J. R.; Cavadas, C.; et al, European Journal of Neuroscience. 2089 - 2102. 8. 27. 2008. http://dx.doi.org/10.1111/j.1460-9568.2008.06172.x . 10.1111/j.1460-9568.2008.06172.x . published European Journal of Neuroscience
Methamphetamine Changes NMDA and AMPA Glutamate Receptor Subunit Levels in the Rat Striatum and Frontal Cortex
Simões, Patrícia F.; Silva, Ana P.; Pereira, Frederico C.; Marques, Elsa; Milhazes, Nuno; Borges, Fernanda; Ribeiro, Carlos F.; Macedo, Tice R., Annals of the New York Academy of Sciences. 232 - 241. 1. 1139. 2008. http://dx.doi.org/10.1196/annals.1432.028 . 10.1196/annals.1432.028 . published Annals of the New York Academy of Sciences
Influence of Chronic Exercise on the Amphetamine-Induced Dopamine Release and Neurodegeneration in the Striatum of the Rat
Marques, Elsa; Vasconcelos, Filipa; Rolo, Marta R.; Pereira, Frederico C.; Silva, Ana P.; Macedo, Tice R.; Ribeiro, Carlos F., Annals of the New York Academy of Sciences. 222 - 231. 1. 1139. 2008. http://dx.doi.org/10.1196/annals.1432.041 . 10.1196/annals.1432.041 . published Annals of the New York Academy of Sciences
Methamphetamine-Induced Early Increase of IL-6 and TNF-a mRNA Expression in the Mouse Brain
Gonçalves, Joana; Martins, Tânia; Ferreira, Raquel; Milhazes, Nuno; Borges, Fernanda; Ribeiro, Carlos Fontes; Malva, João O.; Macedo, Tice R.; Silva, Ana P., Annals of the New York Academy of Sciences. 103 - 111. 1. 1139. 2008. http://dx.doi.org/10.1196/annals.1432.043 . 10.1196/annals.1432.043 . published Annals of the New York Academy of Sciences
Methamphetamine induces alterations on hippocampal NMDA and AMPA receptor subunit levels and impairs spatial working memory
Simões, P.F.; Silva, A.P.; Pereira, F.C.; Marques, E.; Grade, S.; Milhazes, N.; Borges, F.; Ribeiro, C.F.; Macedo, T.R., Neuroscience. 433 - 441. 2. 150. 2007. http://dx.doi.org/10.1016/j.neuroscience.2007.09.044 . 10.1016/j.neuroscience.2007.09.044 . published Neuroscience
Protein kinase C activity blocks neuropeptide Y-mediated inhibition of glutamate release and contributes to excitability of the hippocampus in status epilepticus
Silva, Ana P.; Lourenço, Joana; Xapelli, Sara; Ferreira, Raquel; Kristiansen, Heidi; Woldbye, David P. D.; Oliveira, Catarina R.; Malva, João O., The FASEB Journal. 671 - 681. 3. 21. 2007. http://dx.doi.org/10.1096/fj.06-6163com . 10.1096/fj.06-6163com . published The FASEB Journal
Neuropeptide Y can rescue neurons from cell death following the application of an excitotoxic insult with kainate in rat organotypic hippocampal slice cultures
Xapelli, S.; Silva, A.P.; Ferreira, R.; Malva, J.O., Peptides. 288 - 294. 2. 28. 2007. http://dx.doi.org/10.1016/j.peptides.2006.09.031 . 10.1016/j.peptides.2006.09.031 . published Peptides
Neuropeptide Y as an Endogenous Antiepileptic, Neuroprotective and Pro-Neurogenic Peptide
Xapelli, Sara; Agasse, Fabienne; Ferreira, Raquel; Silva, Ana; Malva, Joao, Recent Patents on CNS Drug Discovery. 315 - 324. 3. 1. 2006. http://dx.doi.org/10.2174/157488906778773689 . 10.2174/157488906778773689 . Recent Patents on CNS Drug Discovery
The Putative Neuroprotective Role of Neuropeptide Y in the Central Nervous System
Silva, A.; Xapelli, S.; Grouzmann, E.; Cavadas, C., Current Drug Target -CNS & Neurological Disorders. 331 - 347. 4. 4. 2005. http://dx.doi.org/10.2174/1568007054546153 . 10.2174/1568007054546153 . published Current Drug Target -CNS & Neurological Disorders
Up-regulation of neuropeptide Y levels and modulation of glutamate release through neuropeptide Y receptors in the hippocampus of kainate-induced epileptic rats
Silva, Ana P.; Xapelli, Sara; Pinheiro, Paulo S.; Ferreira, Raquel; Lourenco, Joana; Cristovao, Armando; Grouzmann, Eric; et al, Journal of Neurochemistry. 163 - 170. 1. 93. 2005. http://dx.doi.org/10.1111/j.1471-4159.2004.03005.x . 10.1111/j.1471-4159.2004.03005.x . published Journal of Neurochemistry
Modulator Effects of Interleukin-1beta and Tumor Necrosis Factor-alpha on AMPA-Induced Excitotoxicity in Mouse Organotypic Hippocampal Slice Cultures
Bernardino, L., Journal of Neuroscience. 6734 - 6744. 29. 25. 2005. http://dx.doi.org/10.1523/jneurosci.1510-05.2005 . 10.1523/jneurosci.1510-05.2005 . published Journal of Neuroscience
Mitochondrial apoptotic cell death and moderate superoxide generation upon selective activation of non-desensitizing AMPA receptors in hippocampal cultures
Rego, A. Cristina; Monteiro, Nuno M.; Silva, Ana P.; Gil, Joana; Malva, João O.; Oliveira, Catarina R., Journal of Neurochemistry. 792 - 804. 4. 86. 2003. http://dx.doi.org/10.1046/j.1471-4159.2003.01898.x . 10.1046/j.1471-4159.2003.01898.x . published Journal of Neurochemistry
Functional interaction between neuropeptide Y receptors and modulation of calcium channels in the rat hippocampus
Silva, A, Neuropharmacology. 282 - 292. 2. 44. 2003. http://dx.doi.org/10.1016/s0028-3908(02)00382-9 . 10.1016/s0028-3908(02)00382-9 . published Neuropharmacology
Activation of neuropeptide Y receptors is neuroprotective against excitotoxicity in organotypic hippocampal slice cultures
SILVA, ANA P.; PINHEIRO, PAULO S.; CARVALHO, ARSÉLIO P.; CARVALHO, CAETANA M.; JAKOBSEN, BIRTHE; ZIMMER, JENS; MALVA, JOÃO O., The FASEB Journal. 1118 - 1120. 9. 17. 2003. http://dx.doi.org/10.1096/fj.02-0885fje . 10.1096/fj.02-0885fje . published The FASEB Journal
Solubilization and immunological identification of presynaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors in the rat hippocampus
Pinheiro, Paulo S.; Rodrigues, Ricardo J.; Silva, Ana P.; Cunha, Rodrigo A.; Oliveira, Catarina R.; Malva, João O., Neuroscience Letters. 97 - 100. 2. 336. 2003. http://dx.doi.org/10.1016/s0304-3940(02)01217-x . 10.1016/s0304-3940(02)01217-x . published Neuroscience Letters
Presynaptic modulation controlling neuronal excitability and epileptogenesis: Role of kainate, adenosine and neuropeptide Y receptors
Malva, J.O.; Silva, A.P.; Cunha, R.A., Neurochemical Research. 1501 - 1515. 10. 28. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0141593557&partnerID=MN8TOARS . 10.1023/A:1025618324593 . Neurochemical Research
Role of kainate receptor activation and desensitization on the [Ca2+]ichanges in cultured rat hippocampal neurons (IF: 3.378)
Silva, Ana P.; Malva, João O.; Ambrósio, António F.; Salgado, António J.; Carvalho, Arsélio P.; Carvalho, Caetana M., Journal of Neuroscience Research. 378 - 386. 5. 65. 2001. http://dx.doi.org/10.1002/jnr.1164 . 10.1002/jnr.1164 . published Journal of Neuroscience Research
Modulation of intracellular calcium changes and glutamate release by neuropeptide Y1 and Y2 receptors in the rat hippocampus: differential effects in CA1, CA3 and dentate gyrus
Silva, Ana P.; Carvalho, Arsélio P.; Carvalho, Caetana M.; Malva, João O., Journal of Neurochemistry. 286 - 296. 2. 79. 2001. http://dx.doi.org/10.1046/j.1471-4159.2001.00560.x . 10.1046/j.1471-4159.2001.00560.x . Journal of Neurochemistry
Inhibition of glutamate release by BIA 2-093 and BIA 2-024, two novel derivatives of carbamazepine, due to blockade of sodium but not calcium channels
Ambrósio, A.F.; Silva, A.P.; Malva, J.O.; Soares-da-Silva, P.; Carvalho, A.P.; Carvalho, C.M., Biochemical Pharmacology. 1271 - 1275. 10. 61. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035873841&partnerID=MN8TOARS . 10.1016/S0006-2952(01)00584-6 . Biochemical Pharmacology
Role of desensitization of AMPA receptors on the neuronal viability and on the [Ca2+]ichanges in cultured rat hippocampal neurons
Ambrósio, António F.; Silva, Ana P.; Malva, João O.; Mesquita, José F.; Carvalho, Arsélio P.; Carvalho, Caetana M., European Journal of Neuroscience. 2021 - 2031. 6. 12. 2000. http://dx.doi.org/10.1046/j.1460-9568.2000.00091.x . 10.1046/j.1460-9568.2000.00091.x . published European Journal of Neuroscience
Neurotoxic/neuroprotective profile of carbamazepine, oxcarbazepine and two new putative antiepileptic drugs, BIA 2-093 and BIA 2-024
Ambrósio, António F; Silva, Ana P; Araújo, Inês; Malva, João O; Soares-da-Silva, Patri´cio; Carvalho, Arsélio P; Carvalho, Caetana M, European Journal of Pharmacology. 191 - 201. 2. 406. 2000. http://dx.doi.org/10.1016/s0014-2999(00)00659-2 . 10.1016/s0014-2999(00)00659-2 . European Journal of Pharmacology
Neurotoxic/neuroprotective profile of carbamazepine, oxcarbazepine and two new putative antiepileptic drugs, BIA 2-093 and BIA 2-024
Ambrósio, A.F.; Silva, A.P.; Araújo, I.; Malva, J.O.; Soares-da-Silva, P.; Carvalho, A.P.; Carvalho, C.M., European Journal of Pharmacology. 191 - 201. 2. 406. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034644868&partnerID=MN8TOARS . 10.1016/S0014-2999(00)00659-2 . European Journal of Pharmacology
Carbamazepine inhibits L-type Ca2+ channels in cultured rat hippocampal neurons stimulated with glutamate receptor agonists
Ambrósio, A.F.; Silva, A.P.; Malva, J.O.; Soares-Da-Silva, P.; Carvalho, A.P.; Carvalho, C.M., Neuropharmacology. 1349 - 1359. 9. 38. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-18244425608&partnerID=MN8TOARS . 10.1016/S0028-3908(99)00058-1 . Neuropharmacology
5 72 out of 72 Publications
All projects
Information of exclusive responsibility of the researcher 15-12-2024 , from platform CIÊNCIAVITAE.
2023/01/01 - 2025/12/31
Lets Talk about Children (Team Member)
101101249
Researcher
Mielenterveysseura; Universidade de Coimbra; Centro Hospitalar e Universitário de Coimbra EPE
Funders: European Commission Seventh Framework Programme for Research and Technological Development Health
2022/01/01 - 2023/12/31
Neutrophils infiltration through blood-brain barrier in traumatic brain injury: Role of CXCL8 (Team member)
EXPL/MED-PAT/0660/2021
Researcher
Faculty of Medicine, University of Coimbra; Universidade de Coimbra Centro de Neurociências e Biologia Celular
2021/09/01 - 2024/09/30
Cerebrovascular hypothesis of stress-induced behavioral alterations (PI)
73/20
Principal investigator
Universidade de Coimbra
Funders: Fundação Bial
2019/01/01 - 2022/12/31
Brain metastases: uncovering the biomechanical crosstalk between cancer cells and the brain microenvironment (BRAIN_METS) (Team member)
POCI-01-0145-FEDER-030625
Researcher
Universidade do Porto Instituto de Patologia e Imunologia Molecular; Instituto Nacional de Engenharia Biomédica; Universidade de Coimbra
Funders: Ministério da Ciência Tecnologia e Ensino Superior
2018/08/19 - 2021/12/31
Alemtuzumab therapy in Multiple Sclerosis: tracking immune cell trafficking, induced molecular mechanisms and aftermath effects (Team member)
GZ-2017-11730
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Sanofi Produtos Farmacêuticos Lda
2018/07/01 - 2021/06/30
Psychostimulant-induced neuroinflammation: new insight in the crosstalk between microglia, astrocytes and neurons (Team member)
PTDC/SAU-TOX/30647/2017
Researcher
Universidade do Porto Instituto de Investigação e Inovação em Saúde
Funders: Fundação para a Ciência e a Tecnologia
2016/05/01 - 2020/12/31
Tackling CANcer STEM CELls: a challenge and an opportunity to advance in anti-cancer therapy (CANCERSTEM) (Team member)
Aviso 03/SAICT/2015
Researcher
Universidade do Porto Instituto de Investigação e Inovação em Saúde
Funders: Portugal 2020
2013/05/01 - 2015/04/30
Methylphenidate and blood-brain barrier changes in health and attention deficit hyperactivity disorder (PI)
PTDC/NEU-OSD/0312/2012
Principal investigator
Universidade de Coimbra; Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Fundação para a Ciência e a Tecnologia
2013/05/01 - 2015/04/30
Neuropeptide Y system: a new potential therapeutic target in diabetic retinopathy (Team member)
PTDC/NEU-OSD/1113/2012
Researcher
Universidade de Coimbra; Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Fundação para a Ciência e a Tecnologia
2011/01/01 - 2012/12/31
Projecto Estratégico - UI 3282 - 2011-2012
PEst-C/SAU/UI3282/2011
Universidade de Coimbra
Funders: Fundação para a Ciência e a Tecnologia
2011/01/01 - 2012/12/31
Unravelling the causes and consequences of methamphetamine-induced impairment of adult hippocampal neurogenesis: is neuropeptide Y a therapeutic tool? (PI)
APS911
Principal investigator
Universidade de Coimbra Faculdade de Medicina
Funders: Faculty of Medicine, University of Coimbra
2011/03/01 - 2014/02/28
DPP-IV inhibitors and GLP-1 as potential therapeutic options for the treatment of diabetic retinopathy: novel insights into the mechanisms of action (Team member)
EFSD/GSK 2010
Researcher
Universidade de Coimbra
Funders: European Foundation for the Study of Diabetes/GlaxoSmithKline
2010/04/01 - 2013/03/31
Histamina versus anti-histamínicos: novos moduladores da neurogénese? (Team member)
PTDC/SAU-NEU/104415/2008
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Fundação para a Ciência e a Tecnologia
2010/04/01 - 2013/09/30
Impact of methamphetamine on the blood-brain barrier: unmasking the underlying mechanisms and the role of neuroinflammation (PI)
PTDC/SAU-FCF/098685/2008
Principal investigator
Universidade de Coimbra; Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Fundação para a Ciência e a Tecnologia
2010/04/01 - 2013/03/31
Role of intercellular communication between endothelial and stem cells in stemness and neurogenesis: new targets for brain repair therapies. (Team member)
PTDC/SAU-NEU/101783/2008
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Science and Technology Foundation, Ministry of Education and Science
2009/01/01 - 2009/10/31
The effect of methamphetamine on mouse subventricular zone neurogenesis (PI)
GAI 04/09
Principal investigator
Universidade de Coimbra Faculdade de Medicina
Funders: Faculty of Medicine, University of Coimbra
2008/01 - 2008/10
IMPACT OF METHAMPHETAMINE ON THE BLOOD-BRAIN BARRIER FUNCTION (PI)
GAI 02/08
Principal investigator
Universidade de Coimbra Faculdade de Medicina
Funders: Universidade de Coimbra Faculdade de Medicina
2007/05/01 - 2010/04/30
Subventricular zone stem cells as a tool for brain repair in temporal lobe epilepsy (Team member)
PTDC/SAU-NEU/68465/2006
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Science and Technology Foundation, Ministry of Education and Science
2007/05/01 - 2010/09/30
Microglial and Neuronal Changes in the Hippocampus Induced by Methamphetamine: Role of Pro-inflammatory Cytokines and Neuropeptide Y (PI)
PTDC/SAU-FCF/67053/2006
Principal investigator
Associação para a Investigação Biomédica e Inovação em Luz e Imagem; Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Fundação para a Ciência e a Tecnologia
2006/01/01 - 2006/10/31
Effect of methamphetamine on the levels of glutamate ionotropic receptors in the striatum, cortex and hippocampus (PI)
GAI 23/06
Principal investigator
Universidade de Coimbra Faculdade de Medicina
Funders: Universidade de Coimbra Faculdade de Medicina
2005/07/01 - 2008/06/30
Biochemical and Behavioural Study of Opioid-Cocaine Interactions
POCI/SAU-FCF/58330/2004
Universidade de Coimbra Centro de Neurociências e Biologia Celular; Universidade de Coimbra; Universidade de Coimbra Faculdade de Ciencias e Tecnologia; Universidade de Coimbra Faculdade de Medicina; Universidade do Porto Faculdade de Farmácia
Funders: Fundação para a Ciência e a Tecnologia
2005/01/01 - 2007/12/31
Biochemical and behavioural study of opioid-cocaine interactions (Team member)
POCTI/SAU-FCF/58330/2004
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Fundação para a Ciência e a Tecnologia
2005/09/01 - 2008/08/31
Neo-neurogenesis and Microglia in Temporal Lobe Epilesy: Role of Pro-inflammatory Cytokines and Neuropeptide Y in Neuroprotection of New Neurons (Team member)
POCTI/SAU-NEU/58492/2004
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Fundação para a Ciência e a Tecnologia
2003/09/01 - 2006/08/31
Immunological and functional identification of ionotropic presynaptic glutamate receptors (Team member)
POCTI/FCB/46804/2002
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Fundação para a Ciência e a Tecnologia
2003/01/01 - 2003/12/31
Coupling of neuropeptide Y receptor activation to intracellular mechanisms mediating glutamate release in hippocampal neurons (PI)
Gulbenkian Programme of Investigation Stimulus, Intracellular Communication field
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Fundação Calouste Gulbenkian
2003/09/01 - 2006/08/31
Neuroprotective effect of neuropeptide Y in excitotoxicity and temporal lobe epilepsy (Team member)
POCTI/NSE/46848/2002
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Fundação para a Ciência e a Tecnologia
2001/04/01 - 2004/03/31
Neurotoxicity mediated by AMPA and kainate receptors in the hippocampus: Role of nitric oxide (Team member)
POCTI/NSE/35875/99
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Fundação para a Ciência e a Tecnologia
2000/10 - 2003/09
Mechanisms of presynaptic kainate receptor inhibition of glutamate and GABA release: Role of epileptogenesis (Team member)
POCTI/36491/99
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Fundação para a Ciência e a Tecnologia
5 28 out of 28 projects
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