Margarida Caldeira

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Researcher

Microscopy Imaging Center of Coimbra (MICC)

E-mail
mcaldeir@cnc.uc.pt
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Margarida Caldeira got her BSc degree in Biochemistry in 2002 at the Faculty of Science and Technology, University of Coimbra, Portugal. During her degree she performed a one year undergraduate trainning at the CNS Discovery Research, Janssen Pharmaceutica N. V., a division of Johnson & Johnson Pharmaceutical Research & Development, Beerse, Belgium. In 2002, Margarida engaged the PhD Programme in Experimental Biology & Biomedicine of the Center for Neuroscience and Cell Biology of Coimbra, University of Coimbra with the research project “Regulation of the Expression of Ionotropic Glutamate Receptors by BDNF in Hippocampal Neurons” under the supervision of Dr. Carlos Duarte. She spent 5 months at University of Michigan Medical School (Michigan, USA) to develop complementary studies for her PhD. Margarida got the PhD degree in Cell Biology in 2007. Her PhD research work resulted in two first author publications in expertise reviews (JBC, 282:12619 and Mol and Cell Neurosci, 35:208), a review publication as a second author (Brit J Pharcol, 153: Suppl1:S310) and was co-author of a chapter in the Handbook of Neurochemistry and Molecular Neurobiology. In 2007 she was granted with a FCT Pos-Doc Fellowship to develop her pos-doctoral research, studying "The ubiquitin proteasome system under excitotoxic conditions" at the Center for Neuroscience and Cell Biology in collaboration with the Center of Ophthalmology, IBILI, Faculty of Medicine, University of Coimbra. This research project resulted several publications, namely the first author paper published in BBA-Mol Basis Disease, 1832: 263 and two important reviews in the field (Prog Neurob, 112: 50 and Neurochem Res, 41:156). In 2008, from February 1st to July 31st, Margarida was recruited by the University of Coimbra as an Invited Assistant Professor, full-time and exclusivity, to lecture in the Department of Life Sciences in the area of Molecular and Cellular Biology. From February 7th of 2011 to August 31st of 2013 she lectured again as an Invited Assistant Professor, full-time and exclusivity, at the Department of Life Sciences of the University of Coimbra in the areas of Genetics, Molecular and Cellular Biology. Her performance as a Professor was evaluated as Very Good. In 2013 she assumed her current position at CNC, as pos-doctoral researcher under the project “Aging, Stress and Chronic Diseases: From Mechanisms to Therapeutics”, supported by QREN - Mais Centro: Programa Operacional Regional do Centro, and RD Units Strategic Plan. Her research is focused on cellular dysfunctions and therapeutics and on the development of bioimaging methodologies. Margarida has collaborated in several research projects, improving the research studies with bioimaging methodologies. Moreover, Margarida has collaborated in the training of postgraduate students and has organized several advanced courses on microscopy and image analysis.

Affiliation

Center for Neuroscience and Cell Biology of Coimbra

Publications

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Information about journal articles, updated at 20-04-2025, from platform CIÊNCIAVITAE.

Methylphenidate has contrasting effects on retinal oxidative stress and mitochondrial dynamics depending on the environment

Sanches, Eliane Swely; Caldeira, Margarida, Journal of Biomedical Science. 2025. submitted Journal of Biomedical Science

Changes in the Endoplasmic Reticulum-Mitochondria Communication in Fibroblasts from Early-Stage Bipolar Disorder Patients

Caldeira, Margarida, International Journal of Molecular Medicine. 2025. accepted International Journal of Molecular Medicine

Activation of the 20S proteasome core particle prevents cell death induced by oxygen- and glucose deprivation in cultured cortical neurons

Salazar, Ivan L.; Curcio, Michele; Mele, Miranda; Vetrone, Rossela; Frisari, Simone; Costa, Rui O.; Caldeira, Margarida V.; Trader, Darci J.; Duarte, Carlos B., Apoptosis. 2025. 10.1007/s10495-025-02097-x . in press Apoptosis

Preparation of Primary Cultures of Embryonic Rat Hippocampal and Cerebrocortical Neurons

Salazar, Ivan; Mele, Miranda; Caldeira, Margarida; Costa, Rui; Correia, Bárbara; Frisari, Simone; Duarte, Carlos, BIO-PROTOCOL. 18. 7. 2017. http://dx.doi.org/10.21769/bioprotoc.2551 . 10.21769/bioprotoc.2551 . BIO-PROTOCOL

Targeting of Cellular Organelles by Fluorescent Plasmid DNA Nanoparticles

Diana Costa; Carolina Costa; Margarida Caldeira; Luísa Cortes; João A. Queiroz; Carla Cruz, Biomacromolecules. 2928 - 2936. 9. 18. 2017. https://doi.org/10.1021/acs.biomac.7b00877 . 10.1021/acs.biomac.7b00877 . Biomacromolecules

Biotinylation and Purification of Plasma Membrane-associated Proteins from Rodent Cultured Neurons

Caldeira, Margarida; Ferreira, Joana; Carvalho, Ana; Duarte, Carlos, BIO-PROTOCOL. 10. 6. 2016. http://dx.doi.org/10.21769/bioprotoc.1807 . 10.21769/bioprotoc.1807 . BIO-PROTOCOL

The role of proteases in hippocampal synaptic plasticity: Putting together small pieces of a complex puzzle

Caldeira, M.V.; Salazar, I.L.; Curcio, M.; Duarte, C.B., Neurochemical Research. 156 - 182. 1-2. 41. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84946811163&partnerID=MN8TOARS . 10.1007/s11064-015-1752-5 . Neurochemical Research

The Role of Proteases in Hippocampal Synaptic Plasticity: Putting Together Small Pieces of a Complex Puzzle.

Salazar IL; Caldeira MV; Curcio M; Duarte CB, 2015. http://europepmc.org/abstract/med/26547197 .

Role of the ubiquitin-proteasome system in brain ischemia: friend or foe?

Caldeira MV; Salazar IL; Curcio M; Canzoniero LM; Duarte CB, 2014. http://europepmc.org/abstract/med/24157661 . 10.1016/j.pneurobio.2013.10.003 .

Excitotoxic stimulation downregulates the ubiquitin-proteasome system through activation of NMDA receptors in cultured hippocampal neurons.

Caldeira MV; Curcio M; Leal G; Salazar IL; Mele M; Santos AR; Melo CV; et al, 2013. http://europepmc.org/abstract/med/23069389 . 10.1016/j.bbadis.2012.10.009 .

Role of the proteasome in excitotoxicity-induced cleavage of glutamic acid decarboxylase in cultured hippocampal neurons.

Baptista MS; Melo CV; Armelão M; Herrmann D; Pimentel DO; Leal G; Caldeira MV; et al, 2010. http://europepmc.org/abstract/med/20405034 . 10.1371/journal.pone.0010139 .

Regulation of AMPA receptors and synaptic plasticity.

Santos SD; Carvalho AL; Caldeira MV; Duarte CB, 2009. http://europepmc.org/abstract/med/18424006 . 10.1016/j.neuroscience.2008.02.037 .

Role of the brain-derived neurotrophic factor at glutamatergic synapses.

Carvalho AL; Caldeira MV; Santos SD; Duarte CB, 2008. http://europepmc.org/abstract/med/18059328 . 10.1038/sj.bjp.0707509 .

Erratum: Brain-derived neurotrophic factor regulates the expression and synaptic delivery of a-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunits in hippocampal neurons (Journal of Biological Chemistry (2007) 282, (12619-12628))

Caldeira, M.V.; Melo, C.V.; Pereira, D.B.; Carvalho, R.; Correia, S.S.; Backos, D.S.; Carvalho, A.L.; Esteban, J.A.; Duarte, C.B., Journal of Biological Chemistry. 37. 282. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34848900818&partnerID=MN8TOARS . Journal of Biological Chemistry

BDNF regulates the expression and traffic of NMDA receptors in cultured hippocampal neurons.

Caldeira MV; Melo CV; Pereira DB; Carvalho RF; Carvalho AL; Duarte CB, 2007. http://europepmc.org/abstract/med/17428676 . 10.1016/j.mcn.2007.02.019 .

Brain-derived neurotrophic factor regulates the expression and synaptic delivery of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunits in hippocampal neurons.

Caldeira MV; Melo CV; Pereira DB; Carvalho R; Correia SS; Backos DS; Carvalho AL; Esteban JA; Duarte CB, 2007. http://europepmc.org/abstract/med/17337442 . 10.1074/jbc.M700607200 .

5 16 out of 16 Publications

All projects

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Information of exclusive responsibility of the researcher 20-04-2025 , from platform CIÊNCIAVITAE.

2015 - 2018

RD Units Strategic Plan 2013-2015 (POCI-01-0145-FEDER-007440)

UID/N-EU/04539/2013

Post-doc Fellow

Universidade de Coimbra Centro de Neurociências e Biologia Celular

2014 - 2019/12

Imaging gene therapy in the brain

PTDC/BBB-NAN/0932/2014

Other

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2013 - 2014

Projecto Estratégico- LA 1- 2013-2014

PEst-C/SAU/LA0001/2013

Other

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2013 - 2015

Projeto Mais Centro - "Aging, Stress And Chronic Diseases: From Mechanisms to Therapeutics"

CENTRO-07-ST24-FEDER-002006

Post-doc Fellow

2012/02/10 - 2015

Regulation of the ubiquitin-proteasome system by BDNF at the hippocampal synapses: role in synaptic plasticity

info:eu-repo/grantAgreement/FCT/COMPETE/120144/PT

Other

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2011 - 2012

Projecto Estratégico- LA 1- 2011-2012

PEst-C/SAU/LA0001/2011

Other

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2010/09/15 - 2014/03/14

Regulation of hnRNPs by the neurotrophin BDNF: role in synaptic plasticity

info:eu-repo/grantAgreement/FCT/5876-PPCDTI/104297/PT

Other

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2009 - 2012

Criação de um laboratório nacional de microarrays de DNA: Fase II

PTDC/BIA-BCM/64745/2006

Other

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2008/04/01 - 2011/03/31

Role of cortactin in the cellular trafficking of AMPA-type glutamate receptors

info:eu-repo/grantAgreement/FCT/5876-PPCDTI/71789/PT

Other

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2007/05/01 - 2010/04/30

Mechanisms of neuronal plasticity and neuroprotection induced by BDNF in the hippocampus: inhibition of degeneration vs. regeneration

info:eu-repo/grantAgreement/FCT/5876-PPCDTI/72283/PT

Other

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2006 - 2010/04/16

Cleavage of the vesicular glutamate (VGLUT) and GABA (VGAT) transporters under excitotoxic conditions: identification of the cleavage sites and functional implications

info:eu-repo/grantAgreement/FCT/5876-PPCDTI/65846/PT

Other

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2005/01/01 - 2007/12/31

Driving AMPA receptors into synapses: role of interacting proteins in the delivery of GluR4- and GluR2L-containing AMPA receptors

info:eu-repo/grantAgreement/FCT/POCI/58955/PT

Other

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2003/03/01 - 2008/02/28

Regulation of the expression of ionotropic glutamate receptors by brain-derived neurotrophic factor (BDNF) in hippocampal neurons

info:eu-repo/grantAgreement/FCT/POCI/46466/PT

PhD Student Fellow

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2003/03/01 - 2007/02/28

Neuroprotective changes in the proteome induced by brain derived neurotrophic factor (BDNF): proteomic studies in cultured hippocampal neurons

info:eu-repo/grantAgreement/FCT/POCI/46441/PT

Other

Universidade de Coimbra Centro de Neurociências e Biologia Celular

5 14 out of 14 projects

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