CNC

Overview

Mariana Colaço completed in 2016 the Bachelor Degree in Biochemistry (University of Coimbra, Faculty of Science and Technology), and the Master Degree in Pharmaceutical Biotechnology in 2018 with a dissertation entitled "Development of nanosized glucan particles with immunostimulatory function as a delivery system for curcumin" (University of Coimbra, Faculty of Pharmacy). Currently, she is a PhD student in Pharmaceutical Sciences (Pharmaceutical Technology) in Faculty of Pharmacy (University of Coimbra) working on the project: "Designing cationic polymer-DNA complexes for nasal immunization against SARS-CoV-2". Since the completion of her MsD (2018), Mariana Colaço has published 2 articles as first author and 4 articles as co-author. She participated as a Master Student Fellow in 2 projects: an international PROSAFE project (GoNanoBioMat) and a project for the development of a therapeutic vaccine against chronic hepatitis B using glucan based adjuvant nanocarriers. In her professional activities has interacted with 15 collaborators/ co-authorship of scientific papers. In her curriculum Ciência Vitae the most frequent terms in the context of scientific and technological output are: Polymeric; nanoparticles; curcumin; glucan; immunotoxicity; anti-inflammatory; therapeutic; safe-by-design; in vitro; immune response.

Publications

Information about journal articles, updated at 01-12-2024, from platform CIÊNCIAVITAE.

Exploring the immunomodulatory properties of glucan particles in human primary cells

Jesus, Sandra; Panão Costa, João; Colaço, Mariana; Lebre, Filipa; Mateus, Daniela; Sebastião, Ana Isabel; Cruz, Maria Teresa; Alfaro-Moreno, Ernesto; Borges, Olga, International Journal of Pharmaceutics. 2024. https://doi.org/10.1016/j.ijpharm.2024.123996 . 10.1016/j.ijpharm.2024.123996 . published International Journal of Pharmaceutics

Endotoxin contamination of nanoparticle formulations: A concern in vaccine adjuvant mechanistic studies

Costa, João Panão; Jesus, Sandra; Colaço, M.; Duarte, Alana; Soares, Edna; Borges, Olga, Vaccine. 3481 - 3485. 23. 41. 2023. http://dx.doi.org/10.1016/j.vaccine.2023.04.063 . 10.1016/j.vaccine.2023.04.063 . published Vaccine

The Effect of Curcumin-Loaded Glucan Nanoparticles on Immune Cells: Size as a Critical Quality Attribute

Colaço, M.; Roquito, Tiago; Costa, João Panão; Cruz, Maria Teresa; Borges, Olga, Pharmaceutics. 2. 15. 2023. http://dx.doi.org/10.3390/pharmaceutics15020623 . 10.3390/pharmaceutics15020623 . published Pharmaceutics

Unravelling the Immunotoxicity of Polycaprolactone Nanoparticles—Effects of Polymer Molecular Weight, Hydrolysis, and Blends

Jesus, Sandra; Bernardi, Natalia; da Silva, Jessica; Colaço, Mariana; Panão Costa, João; Fonte, Pedro; Borges, Olga, Chemical Research in Toxicology. 2819 - 2833. 11. 33. 2020. http://dx.doi.org/10.1021/acs.chemrestox.0c00208 . 10.1021/acs.chemrestox.0c00208 . published Chemical Research in Toxicology

Airborne environmental fine particles induce intense inflammatory response regardless of the absence of heavy metal elements

Colaço, Mariana; Duarte, Alana; Zuzarte, Mónica; Costa, Benilde F.O.; Borges, Olga, Ecotoxicology and Environmental Safety. 195. 2020. http://dx.doi.org/10.1016/j.ecoenv.2020.110500 . 10.1016/j.ecoenv.2020.110500 . published Ecotoxicology and Environmental Safety

Safe-by-Design of Glucan Nanoparticles: Size Matters When Assessing the Immunotoxicity

Colaço, Mariana; Marques, Ana P.; Jesus, Sandra; Duarte, Alana; Borges, Olga, Chemical Research in Toxicology. 2020. http://dx.doi.org/10.1021/acs.chemrestox.9b00467 . 10.1021/acs.chemrestox.9b00467 . published Chemical Research in Toxicology

Chitosan Nanoparticles: Shedding Light on Immunotoxicity and Hemocompatibility

Jesus, Sandra; Marques, Ana Patrícia; Duarte, Alana; Soares, Edna; Costa, João Panão; Colaço, Mariana; Schmutz, Mélanie; et al, Frontiers in Bioengineering and Biotechnology. 100. 8. 2020. http://dx.doi.org/10.3389/fbioe.2020.00100 . 10.3389/fbioe.2020.00100 . published Frontiers in Bioengineering and Biotechnology

Poly(D,L-Lactic Acid) Nanoparticle Size Reduction Increases its Immunotoxicity

Silva, Jessica; Jesus, Sandra; Benardi, Natália; Colaço, Mariana; Borges, Olga, Frontiers in Bioengineering and Biotechnology. 2019. https://doi.org/10.3389/fbioe.2019.00137 . published Frontiers in Bioengineering and Biotechnology

Association of chitosan and aluminium as a new adjuvant strategy for improved vaccination

Lebre, F.; Bento, D.; Ribeiro, J.; Colaço, M.; Borchard, G.; de Lima, M.C. Pedroso; Borges, O., International Journal of Pharmaceutics. 103 - 114. 1-2. 527. 2017. http://dx.doi.org/10.1016/j.ijpharm.2017.05.028 . 10.1016/j.ijpharm.2017.05.028 . published International Journal of Pharmaceutics

5 9 out of 9 Publications

All projects

Information of exclusive responsibility of the researcher 01-12-2024 , from platform CIÊNCIAVITAE.

2021/12/01 - 2022/12/01

Vacina Intranasal genética contra o COVID: estudos de imunização em murganhos

13824

Researcher

Universidade de Coimbra Faculdade de Farmácia

Funders: Gilead Sciences Lda

2019/11/20 - 2021

Hepatitis B therapeutic vaccine: Production of glucan-based nanoparticles towards selective delivery hepatitis B antigens to immune cells to induce antiviral activity

PTDC/MEC-GAS/30331/2017

Research Fellow

Funders: Fundação para a Ciência e a Tecnologia

2017/04/01 - 2019/06/30

Polymeric NanoBioMaterials for drug delivery: developing and implementation of safe-by-design concept enabling safe healthcare solutions

ProSafe/0001/2016

Research Fellow

Funders: Fundação para a Ciência e a Tecnologia

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Mariana Raquel Antunes Colaço

Former Member

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Publications

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