CNC

public.student_biography

Nélio Gonçalves is currently conducting post-doctoral research in Basic Medicine applied to Brain Development. The goal is to tackle key stages of the early CNS development by molecular, immune and pharmacological tools ensuring the comprehension and therapeutic modulation of abnormal brain circuitries resulting in neurodevelopmental disorders showing multiple intellectual disabilities, and with unmet medical needs. His previous research activities were devoted to Oncology tackling the TME by NP-based DDS (Nano Today 2021, 37:101095; IF 16.9) and NK cells' gene-editing against breast and lung cancers; and to Neurology mostly focused on the modulation of the adenosinergic and quality control systems in multiple disorders of the CNS aiming to prevent or alleviate disease progression by either administering drugs (Ann Neurol 2013, 73:655; 2017, 81:407; IF 11.2) or through viral-mediated delivery of classical (Brain 2012, 135:2428; IF:10.9; Neuropsychopharmacol 2016, 41:2862; IF:6.4; Nat Comm 2016, 7:11915; IF:11.5; Hum Mol Genet 2018, 27:3528; IF:7.7) and emerging light-inducible (optogenetic) nucleic acids (Mol Psychiatry 2015, 20:1339; IF:15.2) in diverse genetically modified animal models of disease. Throughout this period, Nélio has had management responsibilities over 5 animal colonies. Nélio has a h-index of 10, resulting from 18 co-authored publications in high impact peer-reviewed journals (all in Q1 and IF>4.0) on both basic and translational science, cited over 618 times (Web of Science source); and 10 publications in Conference Proceedings. He has also authored/co-authored 103 communications in national and international scientific meetings (51 oral communications and 52 poster presentations), involving 10+ collaborations and 100+ collaborators. Together, his work was distinguished by the National Ataxia Foundation, US, best lecture and Portuguese Soc of Neurosciences (best papers, 2). Was also awarded with Best National Talent under 35 years old in the Category of Science at PrémiosNovos2014, by 'Cego, Surdo e Mudo' productions. Additionally, he also actively participated in 25 national and international R&D projects funded by FCT, Santa Casa da Misericórdia (PT), DARPA, NARSAD, NAF, Alzheimer's Assoc. (USA), and by FEDER - QREN (EU), and is the recipient of up to 8 research fellowships and 1 research contract. Within this period, Nélio has lectured in postgraduate PhD (PDBEB-CNC, and Health Sciences, UC) and Master courses (FPharmacy, UC), co-supervise 5 under-graduated' and 5 Master' students, provide scientific and technical guidance for up to 14 PhD students, 6 MSc researchers and 2 lab technicians. He has also regularly participated in the Brain Awareness and Science and Technology weeks, and in the Open Day Lab (2014-2020), thus actively promoting scientific practices and culture. Culture wise, Nélio has coordinated and instructed in 2 Music Schools and prepared 6 Music Summer Intensive Courses, managing human resources and logistics. (last update 2021)

Publications

Information about journal articles, updated at 15-12-2024, from platform CIÊNCIAVITAE.

Increased Synaptic ATP Release and CD73-Mediated Formation of Extracellular Adenosine in the Control of Behavioral and Electrophysiological Modifications Caused by Chronic Stress

Liliana Dias; Daniela Pochmann; Cristina Lemos; Henrique B. Silva; Joana I. Real; Francisco Q. Gonçalves; Daniel Rial; et al, ACS Chemical Neuroscience. 2023. http://dx.doi.org/10.1021/acschemneuro.2c00810 . 10.1021/acschemneuro.2c00810 . ACS Chemical Neuroscience

Increased ATP Release and Higher Impact of Adenosine A2A Receptors on Corticostriatal Plasticity in a Rat Model of Presymptomatic Parkinson’s Disease

Francisco Q. Gonçalves; Filipe C. Matheus; Henrique B. Silva; Joana I. Real; Daniel Rial; Ricardo J. Rodrigues; Jean-Pierre Oses; et al, Molecular Neurobiology. 2023. http://dx.doi.org/10.1007/s12035-022-03162-1 . 10.1007/s12035-022-03162-1 . Molecular Neurobiology

Nucleolin Overexpression Predicts Patient Prognosis While Providing a Framework for Targeted Therapeutic Intervention in Lung Cancer

Ângela Valério-Fernandes; Nuno A. Fonseca; Nélio Gonçalves; Ana F. Cruz; Marta I. Pereira; Ana C. Gregório; Vera Moura; et al, Cancers. 2022. https://doi.org/10.3390/cancers14092217 . 10.3390/cancers14092217 . Cancers

Adenosine A2A receptors control synaptic remodeling in the adult brain

Xinli Xu; Rui O. Beleza; Francisco Q. Gonçalves; Sergio Valbuena; Sofia Alçada-Morais; Nélio Gonçalves; Joana Magalhães; et al, Scientific Reports. 2022. http://dx.doi.org/10.1038/s41598-022-18884-4 . 10.1038/s41598-022-18884-4 . Scientific Reports

Increased ATP release and CD73-mediated adenosine A2A receptor activation mediate convulsion-associated neuronal damage and hippocampal dysfunction

Elisabete Augusto; Francisco Q. Gonçalves; Joana E. Real; Henrique B. Silva; Daniela Pochmann; Tiago S. Silva; Marco Matos; et al, Neurobiology of Disease. 2021. http://dx.doi.org/10.1016/j.nbd.2021.105441 . 10.1016/j.nbd.2021.105441 . Neurobiology of Disease

The Enhanced Efficacy of Intracellular Delivery of Doxorubicin/C6-Ceramide Combination Mediated by the F3 Peptide/Nucleolin System Is Supported by the Downregulation of the PI3K/Akt Pathway

Ana F. Cruz; Mariana B. Caleiras; Nuno A. Fonseca; Nélio Gonçalves; Vera M. Mendes; Susana F. Sampaio; Vera Moura; et al, Cancers. 3052 - 3052. 12. 13. 2021. https://doi.org/10.3390/cancers13123052 . 10.3390/cancers13123052 . Cancers

Cancer Stem Cells and Nucleolin as Drivers of Carcinogenesis

Laura Sofia Carvalho; Nélio Gonçalves; Nuno André Fonseca; João Nuno Moreira, Pharmaceuticals. 60 - 60. 1. 14. 2021. https://doi.org/10.3390/ph14010060 . 10.3390/ph14010060 . Pharmaceuticals

GMP-grade nanoparticle targeted to nucleolin downregulates tumor molecular signature, blocking growth and invasion, at low systemic exposure

Nuno A. Fonseca; Ana C. Gregório; Vera M. Mendes; Rui Lopes; Teresa Abreu; Nélio Gonçalves; Bruno Manadas; et al, Nano Today. 2021. https://doi.org/10.1016/j.nantod.2021.101095 . 10.1016/j.nantod.2021.101095 . Nano Today

Current challenges and emerging opportunities of CAR-T cell therapies

Abreu, Teresa; Fonseca, Nuno A.; Gonçalves, Nélio; Moreira, João Nuno, Journal of Controlled Release. 246 - 261. 319. 2020. http://www.scopus.com/inward/record.url?eid=2-s2.0-85077491524&partnerID=MN8TOARS . 10.1016/j.jconrel.2019.12.047 . published Journal of Controlled Release

Synaptic and memory dysfunction in a ß-amyloid model of early Alzheimer's disease depends on increased formation of ATP-derived extracellular adenosine

Gonçalves, Francisco Queiroz (9913-5AC8-052C); Lopes, João; Silva, Henrique B.; Lemos, Cristina; Silva, António C.; Gonçalves, Nélio; Tomé, Ângelo R.; et al, Neurobiology of Disease. 132. 2019. http://dx.doi.org/10.1016/j.nbd.2019.104570 . 10.1016/j.nbd.2019.104570 . published Neurobiology of Disease

Metabotropic glutamate type 5 receptor requires contactin-associated protein 1 to control memory formation

Morató, Xavier; Luján, R.; Gonçalves, Nélio; Watanabe, M.; Altafaj, X.; Carvalho, Ana Luisa; Fernández-Dueñas, V.; Cunha, Rodrigo A.; Ciruela, Francisco, Human molecular genetics. 3528 - 3541. 20. 27. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85054354803&partnerID=MN8TOARS . 10.1093/hmg/ddy264 . published Human molecular genetics

Adenosine A2A receptors in the rat prelimbic medial prefrontal cortex control delay-based cost-benefit decision making

Leffa, D.T.; Pandolfo, P.; Gonçalves, Nélio; Machado, Nuno J.; de Souza, Caroline M.; Real, Joana; Silva, António Carvalho; et al, Frontiers in Molecular Neuroscience. 11. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85059003991&partnerID=MN8TOARS . 10.3389/fnmol.2018.00475 . published Frontiers in Molecular Neuroscience

Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Triggered by Convulsions

Canas, Paula Margarida Gomes (1C11-C5F1-BC01); Lisiane O. Porciúncula; Simões, Ana; Augusto, Elisabete; Henrique B. Silva; Machado, Nuno J.; Gonçalves, Nélio; et al, eneuro. ENEURO.0385 - 18.2018. 2018. https://doi.org/10.1523/ENEURO.0385-18.2018 . 10.1523/ENEURO.0385-18.2018 . published eneuro

Caffeine alleviates progressive motor deficits in a transgenic mouse model of spinocerebellar ataxia

Gonçalves, Nélio; Simões, Ana Teresa Antunes (E715-7062-B946); Prediger, Rui D.; Hirai, H.; Cunha, Rodrigo A.; Pereira de Almeida, Luis Fernando Morgado, Annals of Neurology. 407 - 418. 3. 81. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85013441188&partnerID=MN8TOARS . 10.1002/ana.24867 . published Annals of Neurology

Adenosine A2A receptors in the amygdala control synaptic plasticity and contextual fear memory

Simões, Ana; Gonçalves, Nélio; Kaster, Manuella; Simões, Ana Teresa Antunes (E715-7062-B946); Nunes, A.; Pereira de Almeida, Luis Fernando Morgado; Goosens, K.A.; Rial, Daniel; Cunha, Rodrigo A., Neuropsychopharmacology. 2862 - 2871. 12. 41. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84978777019&partnerID=MN8TOARS . 10.1038/npp.2016.98 . published Neuropsychopharmacology

Depression as a glial-based synaptic dysfunction

Rial, Daniel; Lemos, C.; Pinheiro, H.; Duarte, J.M.; Gonçalves, Francisco Queiroz (9913-5AC8-052C); Real, Joana; Prediger, R.D.; et al, Frontiers in Cellular Neuroscience. 1 - 11. JAN2016. 9. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84957876863&partnerID=MN8TOARS . 10.3389/fncel.2015.00521 . published Frontiers in Cellular Neuroscience

Early synaptic deficits in the APP/PS1 mouse model of Alzheimer’s disease involve neuronal adenosine A2A receptors

Viana da Silva, Silvia; Haberl, Matthias Georg; Zhang, Pei; Bethge, Philipp; Lemos, Cristina; Gonçalves, Nélio; Gorlewicz, Adam; et al, Nature Communications. 1. 7. 2016. http://dx.doi.org/10.1038/ncomms11915 . 10.1038/ncomms11915 . published Nature Communications

Erratum: Optogenetic activation of intracellular adenosine A2A Receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and impair memory (Molecular Psychiatry (2015) 20, 1339-1349 DOI:10.1038/mp.2014.182)

Li, P.; Rial, Daniel; Canas, Paula Margarida Gomes (1C11-C5F1-BC01); Yoo, J.-H.; Li, W.; Zhou, X.; Wang, Y.; et al, Molecular Psychiatry. 11. 20. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84946495951&partnerID=MN8TOARS . 10.1038/mp.2015.43 . published Molecular Psychiatry

Neuropeptide Y mitigates neuropathology and motor deficits in mouse models of Machado-Joseph disease

Duarte-Neves, Joana; Gonçalves, Nélio; Cunha-Santos, Janete; Simões, Ana Teresa Antunes (E715-7062-B946); den Dunnen, W.F.A.; Hirai, H.; Kügler, Sebastian; Cavadas, Claudia; Pereira de Almeida, Luis Fernando Morgado, Human Molecular Genetics. 5451 - 5463. 19. 24. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84943793236&partnerID=MN8TOARS . 10.1093/hmg/ddv271 . published Human Molecular Genetics

Optogenetic activation of intracellular adenosine A2A receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and impair memory

Li, P.; Rial, Daniel; Canas, Paula Margarida Gomes (1C11-C5F1-BC01); Yoo, J.-H.; Li, W.; Zhou, X.; Wang, Y.; et al, Molecular Psychiatry. 1339 - 1349. 11. 20. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84946498281&partnerID=MN8TOARS . 10.1038/mp.2014.182 . published Molecular Psychiatry

Calpain inhibition reduces ataxin-3 cleavage alleviating neuropathology and motor impairments in mouse models of machado-Joseph disease

Simões, Ana Teresa Antunes (E715-7062-B946); Gonçalves, Nélio; Nobre, Rui Jorge; Duarte, Carlos B.; Pereira de Almeida, Luis Fernando Morgado, Human Molecular Genetics. 4932 - 4944. 18. 23. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84906821927&partnerID=MN8TOARS . 10.1093/hmg/ddu209 . published Human Molecular Genetics

Potentiation of radiotherapy by a localized antiangiogenic gene therapy

Crokart, Nathalie; Danhier, Fabienne; Daugimont, Liévin; Gonçalves, Nélio; Jordan, B.F.; Grégoire, V.; Feron, Olivier; et al, Radiotherapy and Oncology. 252 - 258. 2. 107. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879019526&partnerID=MN8TOARS . 10.1016/j.radonc.2013.03.018 . published Radiotherapy and Oncology

Activation of microglial cells triggers a release of brain-derived neurotrophic factor (BDNF) inducing their proliferation in an adenosine A2A receptor-dependent manner: A2A receptor blockade prevents BDNF release and proliferation of microglia

Gomes, Catarina; Ferreira, Raquel; George, Jimmy; Sanches, Rui; Rodrigues, Diana I; Gonçalves, Nélio; Cunha, Rodrigo A., Journal of Neuroinflammation. 1. 10. 2013. http://dx.doi.org/10.1186/1742-2094-10-16 . 10.1186/1742-2094-10-16 . published Journal of Neuroinflammation

Caffeine and adenosine A2A receptor inactivation decrease striatal neuropathology in a lentiviral-based model of Machado-Joseph disease

Gonçalves, Nélio; Simões, Ana Teresa Antunes (E715-7062-B946); Cunha, Rodrigo A.; Pereira de Almeida, Luis Fernando Morgado, Annals of Neurology. 655 - 666. 5. 73. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878306815&partnerID=MN8TOARS . 10.1002/ana.23866 . published Annals of Neurology

Calpastatin-mediated inhibition of calpains in the mouse brain prevents mutant ataxin 3 proteolysis, nuclear localization and aggregation, relieving Machado-Joseph disease

Simões, Ana Teresa Antunes (E715-7062-B946); Gonçalves, Nélio; Koeppen, Arnulf; Déglon, Nicole; Kügler, Sebastian; Duarte, Carlos B.; Pereira de Almeida, Luis Fernando Morgado, Brain. 2428 - 2439. 8. 135. 2012. http://dx.doi.org/10.1093/brain/aws177 . 10.1093/brain/aws177 . published Brain

5 25 out of 25 Publications

All projects

Information of exclusive responsibility of the researcher 15-12-2024 , from platform CIÊNCIAVITAE.

2018/07 - 2021/07

A2A receptors control axon formation during neuronal development: new strategies to arrest epileptogenesis.

PTDC/MED-NEU/28160/2017

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2017/01/01 - 2019/05/31

CANCEL-STEM: Tackling CANcer STEM CELls: a challenge and an opportunity to advance in anti-cancer therapy

POCI-01-0145-FEDER-016390

Post-doc Fellow

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2017/01 - 2019/05

Towards a single therapy against triple negative breast cancer and neuroblastoma by nucleolin-mediated multicellular targeting with a synergistic drug combination.

ENMed/0005/2015

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2016/05 - 2019/04

Role of astrocytes in the control of memory-focus on adenosine A2A receptors

Provided by PTCRIS: 142785

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2016/05 - 2018/10

Hybrid ionotropic receptors: a new concept of receptor

Provided by PTCRIS: 142196

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2015/11 - 2018/10

P2Y1 receptor-CRMP2 control synaptic loss and memory impairment in early Alzheimer’s Disease

NIRG-15-361884

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Alzheimer's Association

2014/09 - 2015

The up-regulation of hippocampal adenosine A2A receptors is necessary and sufficient to trigger memory dysfunction in Alzheimer’s disease.

MB-98-2014

Post-doc Fellow

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Santa Casa da Misericórdia de Lisboa

2014 - 2016

Role of adenosine A2A receptors in the accumbens and amygdala in the control of chronic stress neuropathology.

Post-doc Fellow

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Brain and Behavior Research Foundation

2013 - 2016

Caffeine alleviation of MJD/SCA3

2013 41(1)

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: National Ataxia Foundation (NAF)

2013/12 - 2015

New Treatments for Stress-induced Dysregulation of Circuits Regulating Reward, Fear, and Habit Learning

09-68-ESR-FP-010

Post-doc Fellow

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Defense Advanced Research Projects Agency

2012/04 - 2014/09

Role of accumbens and amygdala in the control of chronic stress neuropathology

Provided by PTCRIS: 122254

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2011/10 - 2013/11

New Treatments for Stress-induced Dysregulation of Circuits Regulating Reward, Fear, and Habit Learning

DARPA-09-68-ESR-FP-010

Research Fellow

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Defense Advanced Research Projects Agency

2011/04/01 - 2014/08/30

Cell to cell transport of alpha-synuclein in Parkinson´s Disease. The progression factor?

PTDC/SAU-NMC/109955/2009

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2010/02 - 2013/04

The role of calpain-mediated proteolysis of ataxin-3 in Machado-Joseph disease: a molecular therapy approach with viral vectors

99307

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2010/03 - 2012/02

Role of adenosine A2A receptors in microglia and glutamatergic synapses in the control of synaptic plasticity and brain damage

108668

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2007/04/02 - 2007/06/28

Tumoral microenvironment study after the electroporation of a plasmid coding for an antiangiogenic factor.

LSHB-CT-2005-512127

Other

Université catholique de Louvain Louvain Drug Research Institute

Funders: European Commission Sixth Framework Programme

2007 - 2013

Aging, Stress and Chronic Diseases: From Mechanisms to Therapeutics

CENTRO-07-ST24-FEDER-002006

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Universidade de Coimbra Instituto de Investigação Interdisciplinar

5 17 out of 17 projects

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Nélio da Mota Gonçalves

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