Publications
Information about journal articles, updated at 17-12-2023, from platform CIÊNCIAVITAE.
Extracellular communication between brain cells through functional transfer of Cre mRNA
Rufino-Ramos, David; Leandro, K; Perdigão, Pedro (0F1E-EFD6-AF01); O'Brien, K; Pinto, MM; Santana, MM; van Solinge, TS; et al, Molecular Therapy. 2023. in press Molecular Therapy
Retinal Organoids from an AIPL1 CRISPR/Cas9 Knockout Cell Line Successfully Recapitulate the Molecular Features of LCA4 Disease
Pedro Perdigão; Bethany Ollington; Hali Sai; Amy Leung; Almudena Sacristan-Reviriego; Jacqueline van der Spuy, International Journal of Molecular Sciences. 2023. https://www.mdpi.com/1422-0067/24/6/5912 . 10.3390/ijms24065912 . International Journal of Molecular Sciences
Induced Pluripotent Stem Cells and Genome-Editing Tools in Determining Gene Function and Therapy for Inherited Retinal Disorders
Benati, D; Leung, A; Perdigão, P; Toulis, V; van der Spuy, J; Recchia, A, International Journal of Molecular Sciences. 23. 23. 2023. https://www.mdpi.com/1422-0067/23/23/15276 . published International Journal of Molecular Sciences
Modelling Machado-Joseph Disease in patient-derived isogenic lines by CRISPR/Cas9-mediated correction of ATXN3-CAG expansion
Perdigão, P; Matos, Carlos A; Lopes, Sara; Fernandes, Ana Rita; Lopes, Miguel; Conceição, André; Faro, Rosario; et al, ESGCT 29th Annual Congress, European Society of Gene and Cell Therapy, Edinburgh, 2022. 11-10-2022.
Investigation of PTC124-mediated translational readthrough in a retinal organoid model of AIPL1-associated Leber congenital amaurosis
Leung, Amy; Sacristan-Reviriego, Almudena; Perdigão, Pedro R.L.; Sai, Hali; Georgiou, Michalis; Kalitzeos, Angelos; Carr, Amanda-Jayne F.; et al, Stem Cell Reports. 2187 - 2202. 10. 17. 2022. http://dx.doi.org/10.1016/j.stemcr.2022.08.005 . 10.1016/j.stemcr.2022.08.005 . published Stem Cell Reports
Establishing iPSC-derived neuronal cell model to study human insomnia pathophysiology
Carvalhas de Almeida, Catarina; Pereira de Almeida, Luis ; Cavadas, Claudia; Perdigão, Pedro*; Álvaro, Ana Rita* , XVI Symposium of Experimental Biology and Biomedicine Doctoral Programme, University of Coimbra, Coimbra, Portugal . 18-01-2022.
Insomnia patient-derived iPSC neurons with potential for disease modeling
Carvalhas de Almeida, Catarina; Pereira de Almeida, Luis ; Cavadas, Claudia; Perdigão, Pedro*; Álvaro, Ana Rita* , World Spleep Congress 2022, Rome, Italy. 03-2022.
Precise and scarless correction of ATXN3-CAG expansion by CRISPR/Cas9 for the generation of patient-derived MJD isogenic iPSC
Perdigão, Pedro (0F1E-EFD6-AF01); Matos, Carlos A; Lopes, Sara; Fernandes, Ana Rita; Lopes, Miguel; Faro, Rosário; Santana, Magda M; Nobre, Rui Jorge; Pereira de Almeida, Luis , XVII Meeting of the Portuguese Society for Neuroscience, Coimbra, Portugal. 01-12-2021.
Translational readthrough as a potential therapeutic for AIPL1-associated Leber Congenital Amaurosis in a patient-derived iPSC-retinal organoid model
Leung, A; Sacristan-Reviriego, A; Perdigão, Pedro (0F1E-EFD6-AF01); Sai, H; Georgiou, M; Kalitzeos, A; Carr, AJ; et al, bioRxiv. 2021. https://doi.org/10.1101/2021.12.17.473147 . published bioRxiv
Investigation of Ataluren (PTC124) as a potential therapeutic for LCA4 in a patient-derived iPS-retinal organoid model
Leung, A; Sacristan-Reviriego, A; Perdigão, PRL; Bainbridge, J; Michaelides, M; van der Spuy, J, ARVO Annual Meeting 2021. 01-05-2021.
CRISPR-Cas9 correction of OPA1 c.1334G>A: p.R445H restores mitochondrial homeostasis in dominant optic atrophy patient-derived iPSCs
Sladen, Paul E.; Perdigão, Pedro R.L.; Salsbury, Grace; Novoselova, Tatiana; van der Spuy, Jacqueline; Chapple, J. Paul; Yu-Wai-Man, Patrick; Cheetham, Michael E., Molecular Therapy - Nucleic Acids. 432 - 443. 26. 2021. http://dx.doi.org/10.1016/j.omtn.2021.08.015 . 10.1016/j.omtn.2021.08.015 . published Molecular Therapy - Nucleic Acids
"Uma Viagem Rara"
Vinhas, AC; Ferreira, AC; Silva, C; Miranda, C; Henriques, D; Oliveira, D; Ramos, D; et al, PÚBLICO. 28-02-2020. PÚBLICO
Gene-corrected iPSC Lines as a Patient-Specific Model to study LCA5-Associated Retinal Disease
Afanasyeva, T; Perdigão, PRL; Anasthasiou, D; van der Spuy, J; Cheetham, M; Roepman, R; Collin, RWJ, International Society for Stem Cell Research 2020 Virtual Meeting. 20-06-2020.
Protein Delivery of Cell-Penetrating Zinc-Finger Activators Stimulates Latent HIV-1-Infected Cells
Perdigão, Pedro R.L.; Cunha-Santos, Catarina; Barbas, Carlos F.; Santa-Marta, Mariana; Goncalves, Joao, Molecular Therapy - Methods & Clinical Development. 145 - 158. 18. 2020. http://dx.doi.org/10.1016/j.omtm.2020.05.016 . 10.1016/j.omtm.2020.05.016 . published Molecular Therapy - Methods & Clinical Development
Gene and Cell Therapy for AIPL1-Associated Leber Congenital Amaurosis: Challenges and Prospects
Perdigão, Pedro; van der Spuy, J, 2019.
Using iPSC-reprogramming and CRISPR-based genome engineering to model AIPL1-associated Leber congenital amaurosis
Perdigao, PRL; Sacristan-Reviriego, A; Jovanovic, K; Cheetham, M; Brainbridge, J; Michaelides, M; van der Spuy, J, Gene Editing in Ophthalmology Meeting of Macular Society 2019, Oxford, United Kingdom. 2019.
Inhibition of HIV replication through siRNA carried by CXCR4-targeted chimeric nanobody.
Cunha-Santos, C; Perdigao, PRL; Oliveira, JG; Cardoso, M; Manuel, A; Taveira, N; Goncalves, J, Cellular and molecular life sciences : CMLS. 2019. https://doi.org/10.1007/s00018-019-03334-8 . 10.1007/s00018-019-03334-8 . published Cellular and molecular life sciences : CMLS
Using iPSC-reprogramming and CRISPR-based genome engineering to model AIPL1-associated Leber congenital amaurosis
Perdigão, P; Sacristan-Reviriego, A; Jovanovic, K; Cheetham, M; Brainbridge, J; Michaelides, M; van der Spuy, J, UCL Institute of Ophthalmology Early Career Researcher Symposium 2019, London, United Kingdom. 2019.
Using iPSC-reprogramming and CRISPR-based genome engineering to model AIPL1-associated Leber congenital amaurosis.
Perdigao, PRL; Sacristan-Reviriego, A; Jovanovic, K; Cheetham, M; Brainbridge, J; Michaelides, M; van der Spuy, J, XVIIIth International Symposium on Retinal Degeneration 2018, Killarney, Ireland. 09-2018.
Gene-targeted strategies to eliminate HIV latent cells through synthetic activators and suicide lentivectors
Perdigão, Pedro, phd. Universidade de Lisboa Faculdade de Farmácia . 20-06-2017. http://hdl.handle.net/10451/29864 .
Gene- therapeutic approach complementing TALE activators and suicidal vectors target and eliminate HIV latent cells.
Perdigão, P; Gaj, T; Rocha, C; Barbas III, C; Santa-Marta, M; Gonçalves, J, Portuguese Annual Meeting Ciência 2016, Lisbon, Portugal. 2016.
Gene- therapeutic approach complementing TALE activators and suicidal vectors target and eliminate HIV latent cells.
Perdigao, PRL; Gaj, T; Rocha, C; Barbas III, C; Santa-Marta, M; Gonçalves, J, FASEB Science Research Conference: Genome Engineering - Cutting-Edge Research and Applications 2016, Lisbon, Portugal. 06-2016.
Reactivation of Latent HIV-1 Expression by Engineered TALE Transcription Factors.
Perdigão, Pedro; Gaj, T; Santa-Marta, M; Barbas III, C; Goncalves, J, PloS one. 2016. http://europepmc.org/articles/PMC4774903 . 10.1371/journal.pone.0150037 . PloS one
New concept of immunotherapy for manipulation of gene expression
Narciso, S; Santos, AC; Perdigão, P; Gonçalves, J, 8th iMed.ULisboa Postgraduate Students Meeting 2016, Lisbon, Portugal. 2016.
HIV-1 latency reactivation by bacterial molecular agents derived from opportunistic infections
Perdigão, P; Acúrcio, R; Duarte, A; São-José, C; Santa-Marta, M; Moniz-Pereira, J; Gonçalves, J, 7th iMed.UL Postgraduate Students Meeting 2015, Lisbon, Portugal. 2015.
Reactivation of latent HIV-1 expression by engineered TALE transcription factors.
Perdigão, Pedro; Gaj, T; Barbas III, C; Santa-Marta, M; Gonçalves, J, 7th iMed.UL Postgraduate Students Meeting 2015, Lisbon, Portugal. 2015.
Reactivation of latent HIV-1 expression by engineered TALE transcription factors.
Perdigão, P; Gaj, T; Barbas III, C; Santa-Marta, M; Gonçalves, J, ESGCT and FSGT Collaborative Congress 2015, Helsinki, Finland. 2015.
Reactivation of latent HIV-1 expression by engineered TALE transcription factors
Perdigão, Pedro (0F1E-EFD6-AF01); Gaj, Thomas; Barbas III, Carlos F; Santa-Marta, Mariana; Gonçalves, João, 20-10-2015.
Engineered artificial transcription factors as novel tools to eliminate HIV latency
Perdigão, P; Gaj, T; Barbas III, C; Santa-Marta, M; Gonçalves, J, 6th iMed.UL Postgraduate Students Meeting 2014, Lisbon, Portugal. 2014.
Reactivation of latent HIV-1 by extracellular factors secreted by NI-bacteria
Perdigão, P; Santa-Marta, M; Duarte, A; Gonçalves, J, 5th iMed.UL Postgraduate Students Meeting 2013, Lisbon, Portugal. 2013.
Identification of the signaling pathways associated with HIV Latency
Santa-Marta, M; Gardner, R; Perdigão, P; Gonçalves, J, 5th National Meeting on Cell Signalling 2011, Coimbra, Portugal. 2011.
Specific elimination of HIV-1 infected cells using a Tat/Rev-dependent circuit
Perdigão, Pedro, master. Universidade de Lisboa Faculdade de Farmácia . 21-11-2011. http://hdl.handle.net/10451/29864 .
Specific elimination of HIV-1 infected cells using a Tat/Rev-dependent circuit
Santa-Marta, M; Perdigão, P; Gonçalves, J, A Collaborative Solution for Tropical Diseases: The Luso-American Response. Conference on HIV/AIDS research 2011, Lisbon, Portugal. 2011.
5 33 out of 33 Publications
All projects
Information of exclusive responsibility of the researcher 17-12-2023 , from platform CIÊNCIAVITAE.
2024/01/01 - 2029/12/31
GeneT: The Gene Therapy CoE at the Center of Portugal
101059981
Researcher
Universidade de Coimbra
Funders: European Commission
2024/03/01 - 2025/02/28
Engineering RNA-Targeting CRISPR/Cas13 for the Treatment of Spinocerebellar Ataxia Type 3
25124
Principal investigator
Universidade de Coimbra
Funders: AFM-Téléthon
2023/08/01 - 2025/12/31
CiNTech - Technological Hub for Innovation, Translation and Industrialization of Complex Injectable Drugs
C644865576-00000005
Researcher
Universidade de Coimbra
Funders: European Commission
2022 - 2023
(Less)PlasticBrain: Bio Replacing Plasticizers - Impact in the Human Brain Development
(Less)PlasticBrain
Funders: Banco Santander Portugal
2022 - 2023
(Less)PlasticBrain: Bio Replacing Plasticizers - Impact in the Human Brain Development
(Less)PlasticBrain
Researcher
Universidade de Coimbra
Funders: Banco Santander Portugal
2022/01/01 - 2023/12/31
Genome editing to rescue Machado-Joseph disease by alternative splicing
EXPL/MED-NEU/0936/2021
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Fundação para a Ciência e a Tecnologia
2021/10/01 -
Machado-Joseph Disease iPSC Cell Models for Medium Throughput Drug Screening
CT 0091995
Post-doc
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Institut Servier SAS
2020/06/01 - 2023/05/31
Rescue of inherited retinal degeneration by CRISPR base editing
5129 / 5130
Other
University College London Institute of Ophthalmology
Funders: Fight for Sight Foundation
2018/07/01 - 2021/09/30
Blocking neurodegeneration by spreading of gene silencers
PTDC/BTM-SAL/29716/2017
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Fundação para a Ciência e a Tecnologia
2017/11/15 - 2019/07/12
Developing a photoreceptor model of AIPL1 LCA from patient derived induced pluripotent stem cells
R170015A
Post-doc
University College London Institute of Ophthalmology
Funders: Moorfields Eye Hospital
2016/01/01 - 2016/06/30
HIV-1 ERADICATION BY SITE-DIRECTED INTEGRATION
info:eu-repo/grantAgreement/FCT/3599-PPCDT/123638/PT
Research Fellow
Funders: Fundação para a Ciência e a Tecnologia
2014/03/01 - 2016/08/31
An innovative approach to deliver dual-targeting HIV entry inhibitors using cationic liposomes
HIVERA/0003/2013
Instituto de Medicina Molecular João Lobo Antunes; Instituto de Medicina Molecular João Lobo Antunes
Funders: Fundação para a Ciência e a Tecnologia
2014/03 - 2015/12
HIV-1 ERADICATION BY SITE-DIRECTED INTEGRATION
Provided by PTCRIS: 123638
Researcher
Funders: Fundação para a Ciência e a Tecnologia
2014/03 - 2016/02
An innovative approach to deliver dual-targeting HIV entry inhibitors using cationic liposomes
Provided by PTCRIS: 135858
Researcher
Funders: Fundação para a Ciência e a Tecnologia
2013/01 - 2015/03
Strategic Project - UI 775 - 2013-2014
Provided by PTCRIS: 133003
Funders: Fundação para a Ciência e a Tecnologia
2012/01/01 - 2012/12/31
Nanotechnology against viral latency: Sensor strategies to eliminate HIV-1 infected cells.
Design New Approaches to Cure HIV Infection (Round 6)
Universidade de Lisboa Instituto de Investigação do Medicamento
Funders: Bill & Melinda Gates Foundation
2012/01/01 - 2015/12
ERADICATION OF HIV-1 INFECTED CELLS BY TARGETING NANOPARTICLES CARRYING THERAPEUTIC PLASMIDS
info:eu-repo/grantAgreement/FCT/SFRH/SFRH2%FBD2%F819412%F2011/PT
PhD Student Fellow
Funders: Fundação para a Ciência e a Tecnologia
5 17 out of 17 projects
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