Affiliation

Center for Neuroscience and Cell Biology

Publications

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Information about journal articles, updated at 03-11-2024, from platform CIÊNCIAVITAE.

Extracellular vesicle-based delivery of silencing sequences for the treatment of Machado-Joseph disease/spinocerebellar ataxia type 3

Rufino-Ramos, David; Albuquerque, Patrícia R.; Leandro, Kevin; Carmona, Vitor; Martins, Inês M.; Fernandes, Rita; Henriques, Carina; et al, Molecular Therapy. 1275 - 1292. 5. 31. 2023. http://dx.doi.org/10.1016/j.ymthe.2023.04.001 . 10.1016/j.ymthe.2023.04.001 . Molecular Therapy

The Parkinson's-disease-associated mutation LRRK2-G2019S alters dopaminergic differentiation dynamics via NR2F1

Walter, Jonas; Bolognin, Silvia; Poovathingal, Suresh K.; Magni, Stefano; Gérard, Deborah; Antony, Paul M.A.; Nickels, Sarah L.; et al, Cell Reports. 3. 37. 2021. http://dx.doi.org/10.1016/j.celrep.2021.109864 . 10.1016/j.celrep.2021.109864 . published Cell Reports

Neural Stem Cells of Parkinson's Disease Patients Exhibit Aberrant Mitochondrial Morphology and Functionality

Walter, Jonas; Bolognin, Silvia; Antony, Paul M.A.; Nickels, Sarah L.; Poovathingal, Suresh K.; Salamanca, Luis; Magni, Stefano; et al, Stem Cell Reports. 878 - 889. 5. 12. 2019. http://dx.doi.org/10.1016/j.stemcr.2019.03.004 . 10.1016/j.stemcr.2019.03.004 . published Stem Cell Reports

Intersection of exosome secretion and autophagy on alpha-synuclein spreading profile in Parkinson's disease cell models

Perfeito, Rita; Anjos, Vanessa; Marques, Andreia; Nobre, Rui; Garrido, Manuel; Schwamborn, Jens; De Almeida, Luís, Frontiers in Cellular Neuroscience. 13. 2019. http://dx.doi.org/10.3389/conf.fncel.2019.01.00015 . 10.3389/conf.fncel.2019.01.00015 . published Frontiers in Cellular Neuroscience

Optimization of a size-exclusion chromatograhy protocol to isolate plasma-derived extracellular vesicles

Laetitia Gaspar; Magda Santana; Perfeito, Rita; Patrícia Albuquerque; Teresa M. Ribeiro Rodrigues; Henrique Girão; Rui Jorge Nobre; Luís Pereira de Almeida, Journal of Extracellular Vesicles. sup1. 7. 2018. http://dx.doi.org/10.1080/20013078.2018.1461450 . 10.1080/20013078.2018.1461450 . published Journal of Extracellular Vesicles

Extracellular vesicles: Novel promising delivery systems for therapy of brain diseases

Rufino-Ramos, D.; Albuquerque, P.R.; Carmona, V.; Perfeito, R.; Nobre, R.J.; Pereira de Almeida, L., Journal of Controlled Release. 247 - 258. 262. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85026758579&partnerID=MN8TOARS . 10.1016/j.jconrel.2017.07.001 . published Journal of Controlled Release

Alpha-synuclein-induced oxidative stress correlates with altered superoxide dismutase and glutathione synthesis in human neuroblastoma SH-SY5Y cells

Perfeito, R.; Ribeiro, M.; Rego, A.C., Archives of Toxicology. 1245 - 1259. 3. 91. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-84978795483&partnerID=MN8TOARS . 10.1007/s00204-016-1788-6 . published Archives of Toxicology

Expanded and Wild-type Ataxin-3 Modify the Redox Status of SH-SY5Y Cells Overexpressing a-Synuclein

Noronha, C.; Perfeito, R.; Laço, M.; Wüllner, U.; Rego, A.C., Neurochemical Research. 1430 - 1437. 5. 42. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85013849882&partnerID=MN8TOARS . 10.1007/s11064-017-2199-7 . published Neurochemical Research

Autophagy activation prevents alpha-synuclein secretion in exosomes

Perfeito, Rita; Vanessa Anjos; Rui Jorge Nobre; Manuel Garrido; Luís Pereira de Almeida, Journal of Extracellular Vesicles. 1. 5. 2016. http://dx.doi.org/10.3402/jev.v5.31552 . 10.3402/jev.v5.31552 . published Journal of Extracellular Vesicles

Linking alpha-synuclein phosphorylation to reactive oxygen species formation and mitochondrial dysfunction in SH-SY5Y cells

Perfeito, R.; Lázaro, D.F.; Outeiro, T.F.; Rego, A.C., Molecular and Cellular Neuroscience. 51 - 59. 62. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84906751686&partnerID=MN8TOARS . 10.1016/j.mcn.2014.08.002 . published Molecular and Cellular Neuroscience

Reprint of: Revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson disease - Resemblance to the effect of amphetamine drugs of abuse

Perfeito, R.; Cunha-Oliveira, T.; Rego, A.C., Free Radical Biology and Medicine. 186 - 201. 62. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884889978&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2013.05.042 . published Free Radical Biology and Medicine

Role of alpha-synuclein and Parkinson's disease-associated mitochondrial dysfunction,Papel da alfa-sinucleína e da disfunção mitocondrial associada à doença de Parkinson

Perfeito, R.; Rego Prof., A.C., Revista Neurociencias. 273 - 284. 2. 20. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863884807&partnerID=MN8TOARS . published Revista Neurociencias

Revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson disease - Resemblance to the effect of amphetamine drugs of abuse

Perfeito, R.; Cunha-Oliveira, T.; Rego, A.C., Free Radical Biology and Medicine. 1791 - 1806. 9. 53. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867397192&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2012.08.569 . published Free Radical Biology and Medicine

Iron-Induced Oxidative Stress and Rotenone Modify Alpha-synuclein Phosphorylation in a Cellular Model of Parkinson's Disease

Rita Perfeito; Catarina Resende de Oliveira; Ana Cristina Carvalho Rego, Frontiers in Neuroscience. 3. 2009. http://dx.doi.org/10.3389/conf.neuro.01.2009.11.061 . 10.3389/conf.neuro.01.2009.11.061 . published Frontiers in Neuroscience

Alpha-synuclein phosphorylation mediated by iron and rotenone in a cellular model of Parkinson's disease

Perfeito, R.; Oliveira, C.; Rego, A.C., Parkinsonism & Related Disorders. P3.011. 15. 2009. http://dx.doi.org/10.1016/s1353-8020(09)70575-9 . 10.1016/s1353-8020(09)70575-9 . published Parkinsonism & Related Disorders

Trolox protection of myelin membrane in hydrogen peroxide-treated mature oligodendrocytes

Perfeito, R.; Pereira, J.; Oliveira, C.; Bettencourt-Relvas, J.; Rego, A.C., Free Radical Research. 444 - 451. 4. 41. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947493269&partnerID=MN8TOARS . 10.1080/10715760601134442 . published Free Radical Research

All projects

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Information of exclusive responsibility of the researcher 03-11-2024 , from platform CIÊNCIAVITAE.

2023/09/01 -

CinTech - Technological Hub for Innovation, Translation and Industrialization of Complex Injectable Drugs

12345

Researcher

Centro de Inovação em Biomedicina e Biotecnologia (CIBB)

2023/03/01 - 2024/08/31

Pre-clinical evaluation of the brain-targeting AAV-PHP.eB encoding cholesterol hydroxylase CYP46A1 as a therapeutic strategy for spinocerebellar ataxia type 3 - towards the understanding of the neuroprotective mechanism

2022.04788.PTDC

Principal investigator

Centro de Inovação em Biomedicina e Biotecnologia (CIBB); Universidade de Coimbra

Funders: Fundação para a Ciência e a Tecnologia, I.P.

2023/01/01 - 2024/06/30

Conversão Directa de Astrócitos em Neurónios Cerebelares como tratamento Inovador para a Ataxia Espinocerebelosa do Tipo-3

2022.06127.PTDC

Researcher

Centro de Inovação em Biomedicina e Biotecnologia (CIBB); Universidade de Coimbra

Funders: Fundação para a Ciência e a Tecnologia, I.P.

2021/01/01 - 2025/12/31

Centro de Inovação em Biomedicina e Biotecnologia - Laboratório Associado

LA/P/0058/2020

Researcher

CNC.IBILI

2020/01/01 - 2023/12/31

Centro de Inovação em Biomedicina e Biotecnologia

UIDB/04539/2020

Researcher

CNC.IBILI

2020/08/01 - 2020/10/31

Verão com Ciência: Metodologias de Investigação Científica - I&D: Terapia Génica e Células Estaminais

MIC IIIUC

Researcher

Universidade de Coimbra; Universidade de Coimbra Instituto de Investigação Interdisciplinar

Funders: Fundação para a Ciência e a Tecnologia

2020/03 - 2022/12

Intravenous delivery of the brain-targeting AAV-PHPeB encoding the cholesterol hydroxylase CYP46A1 into a mouse model of spinocerebellar ataxia type 3: a promising non-invasive therapeutic strategy

686213

Principal investigator

2019/01 - 2022/12/31

Gene Therapy for Cerebellar Ataxias: restoring cholesterol metabolism by targeting brain cholesterol 24 hydroxylase (CYP46A1) - SCA-CYP (E-RARE International Consortium)

E-Rare-3 JTC 2017

Researcher

CNC.IBILI

2018/06 - 2022/06/14

The impact of induced pluripotent stem cells-derived neuroepithelial stem cells transplantation in Machado-Joseph disease

PTDC/BTM-ORG/30737/2017

Researcher

CNC.IBILI

Funders: Fundação para a Ciência e a Tecnologia, I.P.

2018/07 - 2021/06

Role of microRNA deregulation in Machado-Joseph disease: on the development of a microRNA-based therapeutic strategy

PTDC/MED-NEU/32309/2017

Researcher

CNC.IBILI

Funders: Fundação para a Ciência e a Tecnologia, I.P.

2017/01 - 2020/12

Brain Health 2020

CENTRO-01-0145-FEDER-000008

Researcher

CNC.IBILI

2016/05 - 2019/04

Control of cardiomyocyte proliferation in disease and regenerative medicine

PTDC/BIM-MED/3363/2014

Researcher

CNC.IBILI

Funders: Fundação para a Ciência e a Tecnologia, I.P.

2016/01 - 2016/12

Does the transplantation of mutant ataxin-3-depleted patient-derived NSC alleviates Machado Joseph disease (MJD)?

20126

Researcher

CNC.IBILI

Funders: AFM-Téléthon

2015/01 - 2018/12

CNC.IBILI

UID/NEU/04539/2013

Researcher

CNC.IBILI

Funders: Fundação para a Ciência e a Tecnologia, I.P.

2015/01 - 2015/12

The transplantation of induced pluripotent stem cells (iPSC)-derived neural stem cells (NSC) in Machado-Joseph disease (MJD)

Research Seed Money Award

Researcher

Centro de Neurociências e Biologia Celular

Funders: National Ataxia Foundation

2015/03/01 - 2018/12

Roles and mechanisms of synuclein and ataxin-3 spreading in Parkinson and Machado-Joseph diseases - SynSpread (JPND - International Consortium)

JPND SynSpread: CD/0001/2013

Researcher

Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2015/07/01 - 2019/01/31

Role and mechanisms of alpha-synuclein spreading in Parkinson's disease

SFRH/BPD/100130/2014

Post-doc Fellow

Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia, I.P.

2014/09/01 - 2015/06/30

New strategies to manage brain diseases

CENTRO-07-ST24FEDER-002002

Post-doc Fellow

Centro de Neurociências e Biologia Celular; Universidade de Coimbra

Funders: Universidade de Coimbra

2014/06/01 - 2014/08/31

Cell to cell transport of alpha-synuclein in Parkinson's disease. The progression factor?

PTDC/SAU-NMC/109955/2009

Post-doc Fellow

Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2011/10 - 2012/07

Alpha-synuclein modifications in peripheral blood lymphocytes from sporadic and familial Parkinson's disease patients

PDCR02

Researcher

Centro de Neurociências e Biologia Celular

Funders: Faculdade de Medicina, Universidade de Coimbra

2010/06/01 - 2013/01/31

Deciphering the molecular mechanisms linking alpha-synuclein dysfunction and cytotoxicity in Parkinson's disease - the role of GDNF

Provided by PTCRIS: 101928

Research Technician Fellow

Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2006/06/01 - 2010/05/31

Interplay between alpha-synuclein and oxidative stress in Parkinson's disease cell models

SFRH/BD/25515/2005

PhD Student Fellow

Universidade de Coimbra; Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia, I.P.

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