Overview
Project Summary
Allergies, including atopic dermatitis, allergic asthma and rhinitis, are among the most prevalent chronic inflammatory disorders worldwide and share a strong comorbidity with Attention-Deficit/Hyperactivity Disorder (ADHD). We recently described a microglia-dependent mechanistic study that might justify this comorbidity. In mice, we showed that a premature increase in IL-4 (a central regulator in Th2 immunity and allergies) in early life induces an increase survival of cerebellar neurons, alters cerebellar connectivity and induces ADHD-related behaviors. The Th2brain project aims to understand how the cerebellum is susceptible to IL-4 effects and how IL-4 impacts microglia-dependent cerebellar remodeling in this critical window of postnatal cerebellar development.
Main Goals
The Th2brain aims at understanding how Th2 hyperresponsiveness leads to abnormal behaviors, why is the cerebellum susceptible to these insults and whether microglia the main cellular drivers of ADHD-like behaviors dependent on IL-4.
Coordination
External Team
This project is being performed in collaboration of Judy Allen and Andrew Greenhalgh from the Lydia Becker Institute of Immunology and Inflammation from the University of Manchester.
Partners
Funding
FCT - Fundação para a Ciência e Tecnologia
Project Details
Project Code
2022.02604.PTDC
Start Date
2023-03-25
End Date
2026-03-24
Total Cost
€ 249 267,75
Funding Details
FCT
