Biomarkers
Translational Research
Proteomics/Metabolomics
Mass Spectrometry
Big Data
Translational biomarkers and therapy for Hypoxic-ischemic encephalopathy (HIE)
Biomarker research for psychiatric diseases including schizophrenia, bipolar disorder, and autism spectrum disorder
Translational research for biomarkers of neurodegenerative disorders, including Parkinson's Disease and Alzheimer's Disease
Elucidation of long-term psychotropic medication mechanisms
Interactomics approaches to identify new signaling pathways
Our research group has developed advanced mass spectrometry approaches to be used in multiple biomedical questions.
The approaches range from small molecule quantification, as neurotransmitters and metabolites, to proteome profiling, identification of post-translation modifications, and intact protein analysis to identify proteoforms.
The questions have been mainly focused on understanding cell biology mechanisms through interactomics or proteomics screenings; identification of disease biomarkers directly from human samples or through translational research approaches; elucidation of psychotropic long-term therapy brain modulation; and identification and quantification of drugs and metabolites in health and disease.
Information about journal articles, updated at 01-09-2024, from platform CIÊNCIAVITAE.
Pathophysiological subtypes of mild cognitive impairment due to Alzheimer’s disease identified by CSF proteomics
Moutinho, Daniela; Mendes, Vera M.; Caula, Alessandro; Madeira, Sara C.; Baldeiras, Inês; Guerreiro, Manuela; Cardoso, Sandra; et al, 2024. Translational Neurodegeneration. 1. 13. 2024. http://dx.doi.org/10.1186/s40035-024-00412-1 . 10.1186/s40035-024-00412-1 . published Translational Neurodegeneration
Pine wilt disease: what do we know from proteomics?
Joana Cardoso; MANADAS, BRUNO; Abrantes, I.M.D.O.; ROBERTSON, LEE; Susana Arcos; Maria Teresa Troya; Alfonso Navas; Fonseca, Luís, 2024. BMC Plant Pathology. 2024. https://doi.org/10.1186/s12870-024-04771-9 . published BMC Plant Pathology
A Comparative Analysis of the Venom System between Two Morphotypes of the Sea Anemone Actinia equina
Maria Alcaide; Inês Moutinho Cabral; Lara Carvalho; Vera M. Mendes; António P. Alves de Matos; Bruno Manadas; Leonor Saúde; Mariaelena D’Ambrosio; Pedro M. Costa, 2024. Animals. 2024. https://doi.org/10.3390/ani14060981 . 10.3390/ani14060981 . Animals
Glial-restricted precursors stimulate endogenous cytogenesis and effectively recover emotional deficits in a model of cytogenesis ablation
Joana Martins-Macedo; Bruna Araújo; Sandra I. Anjo; Tiago Silveira-Rosa; Patrícia Patrício; Nuno Dinis Alves; Joana M. Silva; et al, 2024. Molecular Psychiatry. 2024. https://doi.org/10.1038/s41380-024-02490-z . 10.1038/s41380-024-02490-z . Molecular Psychiatry
Cellular Aging Secretes: a Comparison of Bone-Marrow-Derived and Induced Mesenchymal Stem Cells and Their Secretome Over Long-Term Culture
Marote, A.; Santos, D.; Mendes-Pinheiro, B.; Serre-Miranda, C.; Anjo, S.I.; Vieira, J.; Ferreira-Antunes, F.; et al, 2023. Stem Cell Reviews and Reports. 248 - 263. 1. 19. 2023. http://www.scopus.com/inward/record.url?eid=2-s2.0-85138719382&partnerID=MN8TOARS . 10.1007/s12015-022-10453-6 . Stem Cell Reviews and Reports
A peptide-centric approach to analyse quantitative proteomics data- an application to prostate cancer biomarker discovery
Lima, T.; Rodrigues, J.E.; Manadas, B.; Henrique, R.; Fardilha, M.; Vitorino, R., 2023. Journal of Proteomics. 272. 2023. http://www.scopus.com/inward/record.url?eid=2-s2.0-85142764157&partnerID=MN8TOARS . 10.1016/j.jprot.2022.104774 . Journal of Proteomics
Enrichment of hepatic glycogen and plasma glucose from H2 18 O informs gluconeogenic and indirect pathway fluxes in naturally feeding mice
Margarida Coelho; Rohit Mahar; Getachew D. Belew; Alejandra Torres; Cristina Barosa; Fernando Cabral; Ivan Viegas; et al, 2023. NMR in Biomedicine. 2023. https://doi.org/10.1002/nbm.4837 . 10.1002/nbm.4837 . NMR in Biomedicine
Biomarkers of hypoxic–ischemic encephalopathy: a systematic review
Inês Caramelo; Margarida Coelho; Miguel Rosado; Carla M. P. Cardoso; Alexandra Dinis; Carlos B. Duarte; Mário Grãos; Bruno Manadas, 2023. World Journal of Pediatrics. 2023. https://doi.org/10.1007/s12519-023-00698-7 . 10.1007/s12519-023-00698-7 . World Journal of Pediatrics
Proteomics Reveals mRNA Regulation and the Action of Annexins in Thyroid Cancer
Margarida Coelho; João Capela; Sandra I. Anjo; João Pacheco; Margarida Sá Fernandes; Isabel Amendoeira; John G. Jones; Luís Raposo; Bruno Manadas, 2023. International Journal of Molecular Sciences. 2023. https://doi.org/10.3390/ijms241914542 . 10.3390/ijms241914542 . International Journal of Molecular Sciences
An Exploration of Novel Bioactives from the Venomous Marine Annelid Glycera alba
Sónia Campos; Ana P. Rodrigo; Inês Moutinho Cabral; Vera M. Mendes; Bruno Manadas; Mariaelena D’Ambrosio; Pedro M. Costa, 2023. Toxins. 2023. https://doi.org/10.3390/toxins15110655 . 10.3390/toxins15110655 . Toxins
New Insights on Sperm Function in Male Infertility of Unknown Origin: A Multimodal Approach
Rita I. Pacheco; Maria I. Cristo; Sandra Anjo; Silva, Andreia F; Maria Inês Sousa; Renata S. Tavares; Ana Paula Sousa; et al, 2023. Biomolecules. 2023. https://www.mdpi.com/2218-273X/13/10/1462 . 10.3390/biom13101462 . Biomolecules
Functional imaging and neurochemistry identify in vivo neuroprotection mechanisms counteracting excitotoxicity and neurovascular changes in the hippocampus and visual cortex of obese and type 2 diabetic animal models
Beatriz Caramelo; Tamaeh Monteiro-Alfredo; João Martins; José Sereno; João Castelhano; Bruno Manadas; Miguel Castelo-Branco; Paulo Matafome, 2023. Journal of Neurochemistry. 2023. https://doi.org/10.1111/jnc.15825 . 10.1111/jnc.15825 . Journal of Neurochemistry
Peptidomics Unveils Distinct Acetylation Patterns of Histone and Annexin A1 in Differentiated Thyroid Cancer
Margarida Coelho; João Capela; Vera M. Mendes; João Pacheco; Margarida Sá Fernandes; Isabel Amendoeira; John G. Jones; Luís Raposo; Bruno Manadas, 2023. International Journal of Molecular Sciences. 2023. https://doi.org/10.3390/ijms25010376 . 10.3390/ijms25010376 . International Journal of Molecular Sciences
Proteomic and Metabolic Analysis of Pinus halepensis Mill. Embryonal Masses Induced under Heat Stress
Cátia Pereira; Ander Castander-Olarieta; Itziar A. Montalbán; Vera M. Mendes; Sandra Correia; Ana Pedrosa; Bruno Manadas; Paloma Moncaleán; Jorge Canhoto, 2023. International Journal of Molecular Sciences. 2023. https://doi.org/10.3390/ijms24087211 . 10.3390/ijms24087211 . International Journal of Molecular Sciences
Proteomics of sea bass skin-scales exposed to the emerging pollutant fluoxetine compared to estradiol
Pinto, P.I.; Anjos, L.; Estêvão, M.D.; Santos, S.; Santa, C.; Manadas, B.; Monsinjon, T.; Canário, A.V.M.; Power, D.M., 2022. Science of the Total Environment. 814. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85122305160&partnerID=MN8TOARS . 10.1016/j.scitotenv.2021.152671 . Science of the Total Environment
Endogenous Fluorescent Proteins in the Mucus of an Intertidal Polychaeta: Clues for Biotechnology
Ana P. Rodrigo; Ana Lopes; Ricardo Pereira; Sandra I. Anjo; Bruno Manadas; Ana R. Grosso; Pedro V. Baptista; Alexandra R. Fernandes; Pedro M. Costa, 2022. Marine Drugs. 224 - 224. 4. 20. 2022. https://doi.org/10.3390/md20040224 . 10.3390/md20040224 . Marine Drugs
Hypothermia Does Not Boost the Neuroprotection Promoted by Umbilical Cord Blood Cells in a Neonatal Hypoxia-Ischemia Rat Model
Inês Serrenho; Carla M. Cardoso; Mário Grãos; Alexandra Dinis; Bruno Manadas; Graça Baltazar, 2022. International Journal of Molecular Sciences. 2022. https://doi.org/10.3390/ijms24010257 . 10.3390/ijms24010257 . International Journal of Molecular Sciences
Increased Intake of Both Caffeine and Non-Caffeine Coffee Components Is Associated with Reduced NAFLD Severity in Subjects with Type 2 Diabetes
Margarida Coelho; Rita S. Patarrão; Inês Sousa-Lima; Rogério T. Ribeiro; Maria João Meneses; Rita Andrade; Vera M. Mendes; et al, 2022. Nutrients. 2022. https://doi.org/10.3390/nu15010004 . 10.3390/nu15010004 . Nutrients
Macrophage Resistance to Ionizing Radiation Exposure Is Accompanied by Decreased Cathepsin D and Increased Transferrin Receptor 1 Expression
Ana Pinto; Ana Beatriz Machado; Hugo Osorio; Marta Laranjeiro Pinto; Vitorino, R.; Gonçalo C. Justino; Cátia Santa; et al, 2022. Cancers. 2022. https://www.mdpi.com/2072-6694/15/1/270 . 10.3390/cancers15010270 . Cancers
Chronic stress causes striatal disinhibition mediated by SOM-interneurons in male mice
Diana Rodrigues; Luis Jacinto; Margarida Falcão; Ana Carolina Castro; Alexandra Cruz; Cátia Santa; Bruno Manadas; et al, 2022. Nature Communications. 2022. https://doi.org/10.1038/s41467-022-35028-4 . 10.1038/s41467-022-35028-4 . Nature Communications
Mass Spectrometry-Based Proteomic and Metabolomic Profiling of Serum Samples for Discovery and Validation of Tuberculosis Diagnostic Biomarker Signature
Ana Filipa Fernandes; Luís Gafeira Gonçalves; Maria Bento; Sandra I. Anjo; Bruno Manadas; Clara Barroso; Miguel Villar; et al, 2022. International Journal of Molecular Sciences. 2022. https://doi.org/10.3390/ijms232213733 . 10.3390/ijms232213733 . International Journal of Molecular Sciences
Posttranslational modifications of proteins are key features in the identification of CSF biomarkers of multiple sclerosis
Salazar, I.L.; Lourenço, A.S.T.; Manadas, B.; Baldeiras, I.; Ferreira, C.; Teixeira, A.C.; Mendes, V.M.; et al, 2022. Journal of Neuroinflammation. 1. 19. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85124466899&partnerID=MN8TOARS . 10.1186/s12974-022-02404-2 . Journal of Neuroinflammation
Systematic Review and Meta-Analysis of Mass Spectrometry Proteomics Applied to Human Peripheral Fluids to Assess Potential Biomarkers of Schizophrenia
João E. Rodrigues; Ana Martinho; Catia Santa; Nuno Madeira; Manuel Coroa; Vítor Santos; Maria J. Martins; et al, 2022. International Journal of Molecular Sciences. 4917 - 4917. 9. 23. 2022. https://doi.org/10.3390/ijms23094917 . 10.3390/ijms23094917 . International Journal of Molecular Sciences
Optimization of a Protocol for Protein Extraction from Calcified Aortic Valves for Proteomics Applications: Development of a Standard Operating Procedure
Fábio Trindade; Ana F. Ferreira; Francisca Saraiva; Diana Martins; Vera M. Mendes; Carla Sousa; Cristina Gavina; et al, 2022. Proteomes. 2022. https://doi.org/10.3390/proteomes10030030 . 10.3390/proteomes10030030 . Proteomes
COVID-19 Salivary Protein Profile: Unravelling Molecular Aspects of SARS-CoV-2 Infection
Eduardo Esteves; Vera M. Mendes; Bruno Manadas; Rafaela Lopes; Liliana Bernardino; Maria José Correia; Marlene Barros; Ana Cristina Esteves; Nuno Rosa, 2022. Journal of Clinical Medicine. 2022. https://doi.org/10.3390/jcm11195571 . 10.3390/jcm11195571 . Journal of Clinical Medicine
Virulence Biomarkers of Bursaphelenchus xylophilus: A Proteomic Approach
Cardoso, J.M.S.; Anjo, S.I.; Manadas, B.; Silva, H.; Abrantes, I.; Nakamura, K.; Fonseca, L., 2022. Frontiers in Plant Science. 12. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85125060046&partnerID=MN8TOARS . 10.3389/fpls.2021.822289 . Frontiers in Plant Science
Decoding the radiomic and proteomic phenotype of epicardial adipose tissue associated with adverse left atrial remodelling and post-operative atrial fibrillation in aortic stenosis
Mancio, J.; Sousa-Nunes, F.; Martins, R.; Fragao-Marques, M.; Conceicao, G.; Pessoa-Amorim, G.; Barros, A.S.; et al, 2022. European Heart Journal Cardiovascular Imaging. 1248 - 1259. 9. 23. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85136182913&partnerID=MN8TOARS . 10.1093/ehjci/jeac092 . European Heart Journal Cardiovascular Imaging
Parvifloron D-based potential therapy for glioblastoma: Inducing apoptosis via the mitochondria dependent pathway
Magalhães, M.; Domínguez-Martín, E.M.; Jorge, J.; Gonçalves, A.C.; Díaz-Lanza, A.M.; Manadas, B.; Efferth, T.; Rijo, P.; Cabral, C., 2022. Frontiers in Pharmacology. 13. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85140619586&partnerID=MN8TOARS . 10.3389/fphar.2022.1006832 . Frontiers in Pharmacology
More than a simple epithelial layer: multifunctional role of echinoderm coelomic epithelium
Guatelli, S.; Ferrario, C.; Bonasoro, F.; Anjo, S.I.; Manadas, B.; Candia Carnevali, M.D.; Varela Coelho, A.; Sugni, M., 2022. Cell and Tissue Research. 207 - 227. 2. 390. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85137783059&partnerID=MN8TOARS . 10.1007/s00441-022-03678-x . Cell and Tissue Research
Effects of microplastics alone and with adsorbed benzo(a)pyrene on the gills proteome of Scrobicularia plana
Bebianno, M.J.; Mendes, V.M.; O'Donovan, S.; Carteny, C.C.; Keiter, S.; Manadas, B., 2022. Science of the Total Environment. 842. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85133432069&partnerID=MN8TOARS . 10.1016/j.scitotenv.2022.156895 . Science of the Total Environment
Modulation of signaling pathways by DJ-1: An updated overview
Neves, M.; Grãos, M.; Anjo, S.I.; Manadas, B.; Margarida Neves; Mario Graos; Sandra Anjo; MANADAS, BRUNO, 2022. Redox Biology. 51. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85126516555&partnerID=MN8TOARS . 10.1016/j.redox.2022.102283 . accepted Redox Biology
Proteome dataset of sea bass (Dicentrarchus labrax) skin-scales exposed to fluoxetine and estradiol
Anjos, L.; Pinto, P.I.S.; Santos, S.; Estêvão, M.D.; Santa, C.; Manadas, B.; Canário, A.V.M.; Power, D.M., 2022. Data in Brief. 41. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85122311143&partnerID=MN8TOARS . 10.1016/j.dib.2022.107971 . Data in Brief
Chronic pain susceptibility is associated with anhedonic behavior and alterations in the accumbal ubiquitin-proteasome system
Guimarães, M.R.; Anjo, S.I.; Cunha, A.M.; Esteves, M.; Sousa, N.; Almeida, A.; Manadas, B.; Leite-Almeida, H., 2021. Pain. 1722 - 1731. 6. 162. 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85106543286&partnerID=MN8TOARS . 10.1097/j.pain.0000000000002192 . Pain
Chemoprevention and therapeutic role of essential oils and phenolic compounds: Modeling tumor microenvironment in glioblastoma
Magalhães, M.; Manadas, B.; Efferth, T.; Cabral, C., 2021. Pharmacological Research. 169. 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85105057870&partnerID=MN8TOARS . 10.1016/j.phrs.2021.105638 . Pharmacological Research
Disclosing proteins in the leaves of cork oak plants associated with the immune response to Phytophthora cinnamomi inoculation in the roots: A long-term proteomics approach
Coelho, A.C.; Pires, R.; Schutz, G.; Santa, C.; Manadas, B.; Pinto, P., 2021. PLoS ONE. 1 January. 16. 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85100319358&partnerID=MN8TOARS . 10.1371/journal.pone.0245148 . PLoS ONE
Comparative Analysis of Bursaphelenchus xylophilus Secretome Under Pinus pinaster and P. pinea Stimuli
Silva, H.; Anjo, S.I.; Manadas, B.; Abrantes, I.; Fonseca, L.; Cardoso, J.M.S., 2021. Frontiers in Plant Science. 12. 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85107053724&partnerID=MN8TOARS . 10.3389/fpls.2021.668064 . Frontiers in Plant Science
Spotted Fever Group Rickettsia Trigger Species-Specific Alterations in Macrophage Proteome Signatures with Different Impacts in Host Innate Inflammatory Responses
Curto, P.; Santa, C.; Cortes, L.; Manadas, B.; Simões, I., 2021. Microbiology Spectrum. 3. 9. 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85123813061&partnerID=MN8TOARS . 10.1128/SPECTRUM.00814-21 . Microbiology Spectrum
Metabolic parameters as possible diagnostic predictors in first-episode psychosis: An exploratory retrospective cohort study
Sofia Ramos Ferreira; Diana Moura; Pedro Oliveira; Vítor Santos; Miguel Bajouco; Sofia Morais; Manuel Coroa; Bruno Manadas; Nuno Madeira, 2021. Early Intervention in Psychiatry. 2021. https://doi.org/10.1111/eip.13257 . 10.1111/eip.13257 . Early Intervention in Psychiatry
Proteome-Wide Analysis of Heat-Stress in Pinus radiata Somatic Embryos Reveals a Combined Response of Sugar Metabolism and Translational Regulation Mechanisms
Castander-Olarieta, A.; Pereira, C.; Montalbán, I.A.; Mendes, V.M.; Correia, S.; Suárez-Álvarez, S.; Manadas, B.; Canhoto, J.; Moncaleán, P., 2021. Frontiers in Plant Science. 12. 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85104978818&partnerID=MN8TOARS . 10.3389/fpls.2021.631239 . Frontiers in Plant Science
The Enhanced Efficacy of Intracellular Delivery of Doxorubicin/C6-Ceramide Combination Mediated by the F3 Peptide/Nucleolin System Is Supported by the Downregulation of the PI3K/Akt Pathway
Ana F. Cruz; Mariana B. Caleiras; Nuno A. Fonseca; Nélio Gonçalves; Vera M. Mendes; Susana F. Sampaio; Vera Moura; et al, 2021. Cancers. 3052 - 3052. 12. 13. 2021. https://doi.org/10.3390/cancers13123052 . 10.3390/cancers13123052 . Cancers
Specific Antiproliferative Properties of Proteinaceous Toxin Secretions from the Marine Annelid Eulalia sp. onto Ovarian Cancer Cells
Ana P. Rodrigo; Vera M. Mendes; Bruno Manadas; Ana R. Grosso; António P. Alves de Matos; Pedro V. Baptista; Pedro M. Costa; Alexandra R. Fernandes, 2021. Marine Drugs. 2021. https://doi.org/10.3390/md19010031 . 10.3390/md19010031 . Marine Drugs
GMP-grade nanoparticle targeted to nucleolin downregulates tumor molecular signature, blocking growth and invasion, at low systemic exposure
Nuno A. Fonseca; Ana C. Gregório; Vera M. Mendes; Rui Lopes; Teresa Abreu; Nélio Gonçalves; Bruno Manadas; et al, 2021. Nano Today. 101095 - 101095. 37. 2021. https://doi.org/10.1016/j.nantod.2021.101095 . 10.1016/j.nantod.2021.101095 . Nano Today
Hypoxia and Hypoxia-Inducible Factor-1a Regulate Endoplasmic Reticulum Stress in Nucleus Pulposus Cells: Implications of Endoplasmic Reticulum Stress for Extracellular Matrix Secretion
Novais, E.J.; Choi, H.; Madhu, V.; Suyama, K.; Anjo, S.I.; Manadas, B.; Shapiro, I.M.; Salgado, A.J.; Risbud, M.V., 2021. American Journal of Pathology. 487 - 502. 3. 191. 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85099523691&partnerID=MN8TOARS . 10.1016/j.ajpath.2020.11.012 . American Journal of Pathology
Stem Cell Therapy for Neonatal Hypoxic-Ischemic Encephalopathy: A Systematic Review of Preclinical Studies
Inês Serrenho; Miguel Rosado; Alexandra Dinis; Carla M. Cardoso; Mário Grãos; Bruno Manadas; Graça Baltazar, 2021. International Journal of Molecular Sciences. 2021. https://doi.org/10.3390/ijms22063142 . 10.3390/ijms22063142 . International Journal of Molecular Sciences
FA-SAT ncRNA interacts with PKM2 protein: depletion of this complex induces a switch from cell proliferation to apoptosis
Ferreira, D.; Escudeiro, A.; Adega, F.; Anjo, S.I.; Manadas, B.; Chaves, R., 2020. Cellular and Molecular Life Sciences. 1371 - 1386. 7. 77. 2020. http://www.scopus.com/inward/record.url?eid=2-s2.0-85069637568&partnerID=MN8TOARS . 10.1007/s00018-019-03234-x . Cellular and Molecular Life Sciences
A different vision of translational research in biomarker discovery: a pilot study on circulatory mitochondrial proteins as Parkinson’s disease potential biomarkers
Anjo, Sandra I.; dos Santos, Patrícia Valério; Rosado, Luiza; Baltazar, Graça; Baldeiras, Inês; Pires, Diana; Gomes, Andreia; et al, 2020. Translational Neurodegeneration. 1. 9. 2020. http://dx.doi.org/10.1186/s40035-020-00188-0 . 10.1186/s40035-020-00188-0 . published Translational Neurodegeneration
Comparative proteomic analysis of nodulated and non-nodulated Casuarina glauca Sieb. ex Spreng. grown under salinity conditions using sequential window acquisition of all theoretical mass spectra (SWATH-MS)
Graça, Inês; Mendes, Vera M.; Marques, Isabel; Duro, Nuno; Costa, Mário; Ramalho, José C.; Pawlowski, Katharina; et al, 2020. International Journal of Molecular Sciences. 78 - 78. 1. 21. 2020. http://hdl.handle.net/10400.5/19224 . 10.3390/ijms21010078 . International Journal of Molecular Sciences
Cofilin-1 is a mechanosensitive regulator of transcription
Domingues, Catarina; Geraldo, A Margarida; Anjo, Sandra Isabel; Matos, André; Almeida, Cláudio; Caramelo, Inês; Lopes-da-Silva, José A; et al, 2020. 2020. http://hdl.handle.net/10773/30552 . 10.3389/fcell.2020.00678 .
Proteomics-based Predictive Model for the Early Detection of Metastasis and Recurrence in Head and Neck Cancer
Ribeiro, I.P.; Esteves, L.; Anjo, S.I.; Marques, F.; Barroso, L.; Manadas, B.; Carreira, I.M.; Melo, J.B., 2020. Cancer Genomics and Proteomics. 259 - 269. 3. 17. 2020. http://www.scopus.com/inward/record.url?eid=2-s2.0-85084169410&partnerID=MN8TOARS . 10.21873/cgp.20186 . Cancer Genomics and Proteomics
Mitochondrial and Redox Modifications in Huntington Disease Induced Pluripotent Stem Cells Rescued by CRISPR/Cas9 CAGs Targeting
Lopes, C.; Tang, Y.; Anjo, S.I.; Manadas, B.; Onofre, I.; de Almeida, L.P.; Daley, G.Q.; Schlaeger, T.M.; Rego, A.C.C., 2020. Frontiers in Cell and Developmental Biology. 8. 2020. http://www.scopus.com/inward/record.url?eid=2-s2.0-85092059116&partnerID=MN8TOARS . 10.3389/fcell.2020.576592 . Frontiers in Cell and Developmental Biology
Specific Nutritional Biomarker Profiles in Mild Cognitive Impairment and Subjective Cognitive Decline Are Associated With Clinical Progression: The NUDAD Project
Francisca A. de Leeuw; Wiesje M. van der Flier; Betty M. Tijms; Philip Scheltens; Vera M. Mendes; Bruno Manadas; Jörgen Bierau; et al, 2020. Journal of the American Medical Directors Association. 2020. https://doi.org/10.1016/j.jamda.2019.12.009 . 10.1016/j.jamda.2019.12.009 . Journal of the American Medical Directors Association
Epicardial adipose tissue volume and annexin A2/fetuin-A signalling are linked to coronary calcification in advanced coronary artery disease: Computed tomography and proteomic biomarkers from the EPICHEART study
Mancio, J.; Barros, A.S.; Conceicao, G.; Pessoa-Amorim, G.; Santa, C.; Bartosch, C.; Ferreira, W.; et al, 2020. Atherosclerosis. 75 - 83. 292. 2020. http://www.scopus.com/inward/record.url?eid=2-s2.0-85075496821&partnerID=MN8TOARS . 10.1016/j.atherosclerosis.2019.11.015 . Atherosclerosis
Influence of EPICardial adipose tissue in HEART diseases (EPICHEART) study: Protocol for a translational study in coronary atherosclerosis,Influência do Tecido Adiposo Epicárdico nas Doenças Cardíacas (EPICHEART): protocolo para um estudo de translação em aterosclerose coronário
Mancio, J.; Barros, A.S.; Conceicão, G.; Santa, C.; Pessoa-Amorim, G.; Bartosch, C.; Fragao-Marques, M.; et al, 2020. Revista Portuguesa de Cardiologia. 625 - 633. 11. 39. 2020. http://www.scopus.com/inward/record.url?eid=2-s2.0-85095788788&partnerID=MN8TOARS . 10.1016/j.repc.2020.03.017 . Revista Portuguesa de Cardiologia
Analytical methods to monitor dopamine metabolism in plasma: Moving forward with improved diagnosis and treatment of neurological disorders
Abrantes Dias, A.S.; Amaral Pinto, J.C.; Magalhães, M.; Mendes, V.M.; Manadas, B., 2020. Journal of Pharmaceutical and Biomedical Analysis. 187. 2020. http://www.scopus.com/inward/record.url?eid=2-s2.0-85085476273&partnerID=MN8TOARS . 10.1016/j.jpba.2020.113323 . Journal of Pharmaceutical and Biomedical Analysis
Changes in the salivary proteome of beagle dogs after weight loss
Lucena, S.; Coelho, A.V.; Muñoz-Prieto, A.; Anjo, S.I.; Manadas, B.; Capela e Silva, F.; Lamy, E.; Tvarijonaviciute, A., 2020. Domestic Animal Endocrinology. 72. 2020. http://www.scopus.com/inward/record.url?eid=2-s2.0-85083877714&partnerID=MN8TOARS . 10.1016/j.domaniend.2020.106474 . Domestic Animal Endocrinology
The Potential of Metabolomics in the Diagnosis of Thyroid Cancer
Margarida Coelho; Luis Raposo; Brian J. Goodfellow; Luigi Atzori; John Jones; Bruno Manadas, 2020. International Journal of Molecular Sciences. 5272 - 5272. 15. 21. 2020. https://doi.org/10.3390/ijms21155272 . 10.3390/ijms21155272 . International Journal of Molecular Sciences
Proteomic Analyses Reveal New Insights on the Antimicrobial Mechanisms of Chitosan Biopolymers and Their Nanosized Particles against Escherichia coli
Laidson P. Gomes; Sandra I. Anjo; Bruno Manadas; Ana V. Coelho; Vania M. F. Paschoalin, 2019. International Journal of Molecular Sciences. 2019. https://doi.org/10.3390/ijms21010225 . 10.3390/ijms21010225 . International Journal of Molecular Sciences
Experimental data from flesh quality assessment and shelf life monitoring of high pressure processed European sea bass (Dicentrarchus labrax) fillets
Anjos, Liliana; Pinto, Patricia IS; Tsironi, Theofania; Dimopoulos, George; Santos, Soraia; Santa, Cátia; Manadas, Bruno; et al, 2019. 2019. http://hdl.handle.net/10400.1/13462 . 10.1016/j.dib.2019.104451 .
Analysis of the quantitative proteomic signature in PBMCs of first-episode psychosis patients
Santa, Cátia; Coroa, Manuel; Morais, Sofia; Bajouco, Miguel; Anjo, Sandra; Baldeiras, Ines; Madeira, Nuno; Macedo, António; MANADAS, BRUNO, 2019. Frontiers in Cellular Neuroscience. 13. 2019. http://dx.doi.org/10.3389/conf.fncel.2019.01.00005 . 10.3389/conf.fncel.2019.01.00005 . published Frontiers in Cellular Neuroscience
An atypical aspartic protease modulates lateral root development in Arabidopsis thaliana
Soares, A.; Niedermaier, S.; Faro, R.; Loos, A.; Manadas, B.; Faro, C.; Huesgen, P.F.; Cheung, A.Y.; Simões, I., 2019. Journal of Experimental Botany. 2157 - 2171. 7. 70. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85068490019&partnerID=MN8TOARS . 10.1093/jxb/erz059 . Journal of Experimental Botany
Validation of an LC-MS/MS Method for the Quantification of Caffeine and Theobromine Using Non-Matched Matrix Calibration Curve
Vera M. Mendes; Margarida Coelho; Angelo R. Tomé; Rodrigo A. Cunha; Bruno Manadas, 2019. Molecules. 2019. https://doi.org/10.3390/molecules24162863 . 10.3390/molecules24162863 . Molecules
Comparative proteomic analysis of saliva from dogs with and without obesity-related metabolic dysfuntion
Sónia Lucena; Ana Varela Coelho; Sandra I. Anjo; Bruno Manadas; Vladimir Mrljak; Fernando Capela e Silva; Elsa Lamy; Asta Tvarijonaviciute, 2019. Journal of Proteomics. 65 - 72. 201. 2019. https://doi.org/10.1016/j.jprot.2019.04.010 . 10.1016/j.jprot.2019.04.010 . Journal of Proteomics
High pressure processing of European sea bass (Dicentrarchus labrax) fillets and tools for flesh quality and shelf life monitoring
Tsironi, Theofania; Anjos, Liliana; Pinto, Patricia IS; Dimopoulos, George; Santos, Soraia; Santa, Cátia; Manadas, Bruno; et al, 2019. 2019. http://hdl.handle.net/10400.1/13638 . 10.1016/j.jfoodeng.2019.05.010 .
Bone marrow mesenchymal stem cells' secretome exerts neuroprotective effects in a Parkinson's disease rat model
Pinheiro, Bárbara Filipa Mendes; Anjo, Sandra I.; Manadas, Bruno; da Silva, Jorge D.; Marote, Ana Maria Franco Aveiro; Behie, Leo A.; Teixeira, Fábio G.; Salgado, A. J., 2019. 2019. http://hdl.handle.net/1822/67311 . 10.3389/fbioe.2019.00294 .
Pre-analytical stability of novel cerebrospinal fluid biomarkers
Willemse, E.A.J.; Vermeiren, Y.; Garcia-Ayllon, M.-S.; Bridel, C.; De Deyn, P.P.; Engelborghs, S.; van der Flier, W.M.; et al, 2019. Clinica Chimica Acta. 204 - 211. 497. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85069842833&partnerID=MN8TOARS . 10.1016/j.cca.2019.07.024 . Clinica Chimica Acta
Use of recombinant proteins as a simple and robust normalization method for untargeted proteomics screening: exhaustive performance assessment
Anjo, S.I.; Simões, I.; Castanheira, P.; Grãos, M.; Manadas, B., 2019. Talanta. 205. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85069659407&partnerID=MN8TOARS . 10.1016/j.talanta.2019.120163 . Talanta
Changes in the intestinal mucosal proteome of turkeys (Meleagris gallopavo) infected with haemorrhagic enteritis virus
Marques, A.T.; Anjo, S.I.; Bhide, M.; Varela Coelho, A.; Manadas, B.; Lecchi, C.; Grilli, G.; Ceciliani, F., 2019. Veterinary Immunology and Immunopathology. 213. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85067345000&partnerID=MN8TOARS . 10.1016/j.vetimm.2019.06.001 . Veterinary Immunology and Immunopathology
Meningeal ¿d T cell-derived IL-17 controls synaptic plasticity and short-term memory
Ribeiro, M.; Brigas, H.C.; Temido-Ferreira, M.; Pousinha, P.A.; Regen, T.; Santa, C.; Coelho, J.E.; et al, 2019. Science Immunology. 40. 4. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85073157928&partnerID=MN8TOARS . 10.1126/sciimmunol.aay5199 . Science Immunology
oxSWATH: An integrative method for a comprehensive redox-centered analysis combined with a generic differential proteomics screening
Sandra I. Anjo; Matilde N. Melo; Liliana R. Loureiro; Lúcia Sabala; Pedro Castanheira; Mário Grãos; Bruno Manadas, 2019. Redox Biology. 101130 - 101130. 2019. https://doi.org/10.1016/j.redox.2019.101130 . 10.1016/j.redox.2019.101130 . Redox Biology
Proteomics and antioxidant enzymes reveal different mechanisms of toxicity induced by ionic and nanoparticulate silver in bacteria
Barros, D.; Pradhan, A.; Mendes, V.M.; Manadas, B.; Santos, P.M.; Pascoal, C.; Cássio, F., 2019. Environmental Science: Nano. 1207 - 1218. 4. 6. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85064263150&partnerID=MN8TOARS . 10.1039/c8en01067f . Environmental Science: Nano
Corrigendum to “oxSWATH: An integrative method for a comprehensive redox-centered analysis combined with a generic differential proteomics screening” (Redox Biology (2019) 22, (S2213231718311856), (10.1016/j.redox.2019.101130))
Anjo, S.I.; Melo, M.N.; Loureiro, L.R.; Sabala, L.; Castanheira, P.; Grãos, M.; Manadas, B., 2019. Redox Biology. 26. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85067256447&partnerID=MN8TOARS . 10.1016/j.redox.2019.101257 . Redox Biology
A pathogen and a non-pathogen spotted fever group rickettsiatrigger differential proteome signatures in macrophages
Curto, P.; Santa, C.; Allen, P.; Manadas, B.; Simões, I.; Martinez, J.J., 2019. Frontiers in Cellular and Infection Microbiology. MAR. 9. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85063647273&partnerID=MN8TOARS . 10.3389/fcimb.2019.00043 . Frontiers in Cellular and Infection Microbiology
A translational view of cells' secretome analysis - from untargeted proteomics to potential circulating biomarkers
Anjo, S.I.; Manadas, B., 2018. Biochimie. 37 - 49. 155. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85048135989&partnerID=MN8TOARS . 10.1016/j.biochi.2018.05.007 . Biochimie
Elucidation of the dynamic nature of interactome networks: A practical tutorial
Anjo, S.I.; Martins-Marques, T.; Pereira, P.; Girão, H.; Manadas, B., 2018. Journal of Proteomics. 116 - 126. 171. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85018674162&partnerID=MN8TOARS . 10.1016/j.jprot.2017.04.011 . Journal of Proteomics
Matrisome Profiling during Intervertebral Disc Development and Ageing
Caldeira, J.; Santa, C.; Osório, H.; Molinos, M.; Manadas, B.; Goncalves, R.; Barbosa, M., 2017. Scientific Reports. 1. 7. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85029508543&partnerID=MN8TOARS . 10.1038/s41598-017-11960-0 . Scientific Reports
Functional and structural characterization of synthetic cardosin B-derived rennet
Almeida, C.M.; Manso, J.A.; Figueiredo, A.C.; Antunes, L.; Cruz, R.; Manadas, B.; Bur, D.; et al, 2017. Applied Microbiology and Biotechnology. 6951 - 6968. 18. 101. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85026776770&partnerID=MN8TOARS . 10.1007/s00253-017-8445-8 . Applied Microbiology and Biotechnology
Insights into the human brain proteome: Disclosing the biological meaning of protein networks in cerebrospinal fluid
Bastos, P.; Ferreira, R.; Manadas, B.; Moreira, P.I.; Vitorino, R., 2017. Critical Reviews in Clinical Laboratory Sciences. 185 - 204. 3. 54. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85019117156&partnerID=MN8TOARS . 10.1080/10408363.2017.1299682 . Critical Reviews in Clinical Laboratory Sciences
A fractionation approach applying chelating magnetic nanoparticles to characterize pericardial fluid's proteome
Trindade, F.; Bastos, P.; Leite-Moreira, A.; Manadas, B.; Ferreira, R.; Soares, S.F.; Daniel-da-Silva, A.L.; Falcão-Pires, I.; Vitorino, R., 2017. Archives of Biochemistry and Biophysics. 1 - 10. 634. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85030090771&partnerID=MN8TOARS . 10.1016/j.abb.2017.09.016 . Archives of Biochemistry and Biophysics
EDTA-functionalized magnetic nanoparticles: A suitable platform for the analysis of low abundance urinary proteins
Bastos, P.; Trindade, F.; Ferreira, R.; Leite-Moreira, A.; Falcão-Pires, I.; Manadas, B.; Daniel-da-Silva, A.L.; Vitorino, R., 2017. Talanta. 81 - 88. 170. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85016933823&partnerID=MN8TOARS . 10.1016/j.talanta.2017.03.087 . Talanta
A proteomic and ultrastructural characterization of Aspergillus fumigatus' conidia adaptation at different culture ages
Anjo, S.I.; Figueiredo, F.; Fernandes, R.; Manadas, B.; Oliveira, M., 2017. Journal of Proteomics. 47 - 56. 161. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85017103862&partnerID=MN8TOARS . 10.1016/j.jprot.2017.03.021 . Journal of Proteomics
SWATH-MS as a tool for biomarker discovery: From basic research to clinical applications
Anjo, S.I.; Santa, C.; Manadas, B., 2017. Proteomics. 3-4. 17. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85012914613&partnerID=MN8TOARS . 10.1002/pmic.201600278 . Proteomics
Enzymatic properties, evidence for in vivo expression, and intracellular localization of shewasin D, the pepsin homolog from Shewanella denitrificans
Leal, A.R.; Cruz, R.; Bur, D.; Huesgen, P.F.; Faro, R.; Manadas, B.; Wlodawer, A.; Faro, C.; Simoes, I., 2016. Scientific Reports. 6. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84962833456&partnerID=MN8TOARS . 10.1038/srep23869 . Scientific Reports
Protein Quality Assessment on Saliva Samples for Biobanking Purposes
Rosa, N.; Marques, J.; Esteves, E.; Fernandes, M.; Mendes, V.M.; Afonso, A.; Dias, S.; et al, 2016. Biopreservation and Biobanking. 289 - 297. 4. 14. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84981350223&partnerID=MN8TOARS . 10.1089/bio.2015.0054 . Biopreservation and Biobanking
Unveiling the Differences of Secretome of Human Bone Marrow Mesenchymal Stem Cells, Adipose Tissue-Derived Stem Cells, and Human Umbilical Cord Perivascular Cells: A Proteomic Analysis
Pires, A.O.; Mendes-Pinheiro, B.; Teixeira, F.G.; Anjo, S.I.; Ribeiro-Samy, S.; Gomes, E.D.; Serra, S.C.; et al, 2016. Stem Cells and Development. 1073 - 1083. 14. 25. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84978401618&partnerID=MN8TOARS . 10.1089/scd.2016.0048 . Stem Cells and Development
A reference library of peripheral blood mononuclear cells for SWATH-MS analysis
Silva, C.; Santa, C.; Anjo, S.I.; Manadas, B., 2016. Proteomics - Clinical Applications. 760 - 764. 7. 10. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84979075975&partnerID=MN8TOARS . 10.1002/prca.201600070 . Proteomics - Clinical Applications
Modulation of the Mesenchymal Stem Cell Secretome Using Computer-Controlled Bioreactors: Impact on Neuronal Cell Proliferation, Survival and Differentiation
Teixeira, F.G.; Panchalingam, K.M.; Assunção-Silva, R.; Serra, S.C.; Mendes-Pinheiro, B.; Patrício, P.; Jung, S.; et al, 2016. Scientific Reports. 6. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84974718908&partnerID=MN8TOARS . 10.1038/srep27791 . Scientific Reports
Direct analysis of [6,6-<sup>2</sup>H<inf>2</inf>]glucose and [U-<sup>13</sup>C<inf>6</inf>]glucose dry blood spot enrichments by LC-MS/MS
Coelho, M.; Mendes, V.M.; Lima, I.S.; Martins, F.O.; Fernandes, A.B.; Macedo, M.P.; Jones, J.G.; Manadas, B., 2016. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 242 - 248. 1022. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84963956082&partnerID=MN8TOARS . 10.1016/j.jchromb.2016.04.027 . Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
Protein precipitation of diluted samples in SDS-containing buffer with acetone leads to higher protein recovery and reproducibility in comparison with TCA/acetone approach
Santa, C.; Anjo, S.I.; Manadas, B., 2016. Proteomics. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84971222028&partnerID=MN8TOARS . 10.1002/pmic.201600024 . Proteomics
Bioaccessibility and changes on cylindrospermopsin concentration in edible mussels with storage and processing time
Freitas, M.; Azevedo, J.; Carvalho, A.P.; Mendes, V.M.; Manadas, B.; Campos, A.; Vasconcelos, V.; et al, 2016. Food Control. 567 - 574. 59. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84934975039&partnerID=MN8TOARS . 10.1016/j.foodcont.2015.06.025 . Food Control
Bursaphelenchus xylophilus and B. mucronatus secretomes: A comparative proteomic analysis
Cardoso, J.M.S.; Anjo, S.I.; Fonseca, L.; Egas, C.; Manadas, B.; Abrantes, I., 2016. Scientific Reports. 6. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-85006073833&partnerID=MN8TOARS . 10.1038/srep39007 . Scientific Reports
Erratum: Unveiling the effects of the secretome of mesenchymal progenitors from the umbilical cord in different neuronal cell populations (Biochimie (2013) 95:12 (2297-2303) DOI: 10.1016/j.biochi.2013.06.028)
Fraga, J.S.; Silva, N.A.; Lourenço, A.S.; Gonçalves, V.; Neves, N.M.; Reis, R.L.; Rodrigues, A.J.; et al, 2016. Biochimie. 336 - 336. 121. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84957818600&partnerID=MN8TOARS . 10.1016/j.biochi.2015.11.025 . Biochimie
Does Caffeine Consumption Modify Cerebrospinal Fluid Amyloid-ß Levels in Patients with Alzheimer's Disease?
Travassos M; Santana I; Baldeiras I; Tsolaki M; Gkatzima O; Sermin G; Yener GG; et al, 2015. 2015. http://europepmc.org/abstract/med/26401784 . 10.3233/JAD-150374 .
Gap junctional protein Cx<inf>43</inf> is involved in the communication between extracellular vesicles and mammalian cells
Soares, A.R.; Martins-Marques, T.; Ribeiro-Rodrigues, T.; Ferreira, J.V.; Catarino, S.; Pinho, M.J.; Zuzarte, M.; et al, 2015. Scientific Reports. 5. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84939865125&partnerID=MN8TOARS . 10.1038/srep13243 . Scientific Reports
Do hypoxia/normoxia culturing conditions change the neuroregulatory profile of Wharton Jelly mesenchymal stem cell secretome?
Teixeira FG; Panchalingam KM; Anjo SI; Manadas B; Pereira R; Sousa N; Salgado AJ; et al, 2015. Introduction: The use of human umbilical cord Wharton Jelly-derived mesenchymal stem cells (hWJ-MSCs) has been considered a new potential source for future safe applications in regenerative medicine. Indeed, the application of hWJ-MSCs into different animal models of disease, including those from the central nervous system, has shown remarkable therapeutic benefits mostly associated with their sec. 2015. http://europepmc.org/abstract/med/26204925 . 10.1186/s13287-015-0124-z . Introduction: The use of human umbilical cord Wharton Jelly-derived mesenchymal stem cells (hWJ-MSCs) has been considered a new potential source for future safe applications in regenerative medicine. Indeed, the application of hWJ-MSCs into different animal models of disease, including those from the central nervous system, has shown remarkable therapeutic benefits mostly associated with their sec
Corrigendum: Gap junctional protein Cx43 is involved in the communication between extracellular vesicles and mammalian cells.
Soares AR; Martins-Marques T; Ribeiro-Rodrigues T; Ferreira JV; Catarino S; Pinho MJ; Zuzarte M; et al, 2015. 2015. http://europepmc.org/abstract/med/26445927 . 10.1038/srep14888 .
Reduced a-MSH Underlies Hypothalamic ER-Stress-Induced Hepatic Gluconeogenesis
Schneeberger, M.; Gómez-Valadés, A.G.; Altirriba, J.; Sebastián, D.; Ramírez, S.; Garcia, A.; Esteban, Y.; et al, 2015. Cell Reports. 361 - 370. 3. 12. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937518875&partnerID=MN8TOARS . 10.1016/j.celrep.2015.06.041 . Cell Reports
Effect of Global ATGL Knockout on Murine Fasting Glucose Kinetics
Coelho, M.; Nunes, P.; Mendes, V.M.; Manadas, B.; Heerschap, A.; Jones, J.G., 2015. Journal of Diabetes Research. 2015. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937692377&partnerID=MN8TOARS . 10.1155/2015/542029 . Journal of Diabetes Research
Short GeLC-SWATH: A fast and reliable quantitative approach for proteomic screenings
Anjo, S.I.; Santa, C.; Manadas, B., 2015. Proteomics. 757 - 762. 4. 15. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84922847099&partnerID=MN8TOARS . 10.1002/pmic.201400221 . Proteomics
Interacting network of the gap junction protein connexin43 is modulated by ischemia and reperfusion in the heart.
Martins-Marques T; Anjo SI; Pereira P; Manadas B; Girao H; Martins-Marques, T.; Anjo, S.I.; et al, 2015. Molecular and Cellular Proteomics. 3040 - 3055. 11. 14. 2015. http://europepmc.org/abstract/med/26316108 . 10.1074/mcp.M115.052894 . Molecular and Cellular Proteomics
Ser119 phosphorylation modulates the activity and conformation of PRRXL1, a homeodomain transcription factor
Soares-Dos-Reis, R.; Pessoa, A.S.; Matos, M.R.; Falcão, M.; Mendes, V.M.; Manadas, B.; Monteiro, F.A.; Lima, D.; Reguenga, C., 2014. Biochemical Journal. 441 - 453. 3. 459. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84898656809&partnerID=MN8TOARS . 10.1042/BJ20131014 . Biochemical Journal
Unveiling the effects of the secretome of mesenchymal progenitors from the umbilical cord in different neuronal cell populations
Fraga, J.S.; Silva, N.A.; Lourenço, A.S.; Gonçalves, V.; Neves, N.M.; Reis, R.L.; Rodrigues, A.J.; et al, 2013. Biochimie. 2297 - 2303. 12. 95. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887824472&partnerID=MN8TOARS . 10.1016/j.biochi.2013.06.028 . Biochimie
Comparative analysis of the exoproteomes of listeria monocytogenes strains grown at low temperatures
Cabrita, P.; Batista, S.; Machado, H.; Moes, S.; Jenö, P.; Manadas, B.; Trigo, M.J.; et al, 2013. Foodborne Pathogens and Disease. 428 - 434. 5. 10. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879104474&partnerID=MN8TOARS . 10.1089/fpd.2012.1385 . Foodborne Pathogens and Disease
Toward a standardized saliva proteome analysis methodology
Vitorino, R.; Guedes, S.; Manadas, B.; Ferreira, R.; Amado, F., 2012. Journal of Proteomics. 5140 - 5165. 17. 75. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865548707&partnerID=MN8TOARS . 10.1016/j.jprot.2012.05.045 . Journal of Proteomics
Comparative proteomic analysis of auxin-induced embryogenic and nonembryogenic tissues of the solanaceous tree c yphomandra betacea (tamarillo)
Correia, S.; Vinhas, R.; Manadas, B.; Lourenço, A.S.; Veríssimo, P.; Canhoto, J.M., 2012. Journal of Proteome Research. 1666 - 1675. 3. 11. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857806173&partnerID=MN8TOARS . 10.1021/pr200856w . Journal of Proteome Research
Partitioning the proteome: Phase separation for targeted analysis of membrane proteins in human post-mortem brain
English, J.A.; Manadas, B.; Scaife, C.; Cotter, D.R.; Dunn, M.J., 2012. PLoS ONE. 6. 7. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862702997&partnerID=MN8TOARS . 10.1371/journal.pone.0039509 . PLoS ONE
Pollen proteases compromise the airway epithelial barrier through degradation of transmembrane adhesion proteins and lung bioactive peptides
Vinhas, R.; Cortes, L.; Cardoso, I.; Mendes, V.M.; Manadas, B.; Todo-Bom, A.; Pires, E.; Veríssimo, P., 2011. Allergy: European Journal of Allergy and Clinical Immunology. 1088 - 1098. 8. 66. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960015037&partnerID=MN8TOARS . 10.1111/j.1398-9995.2011.02598.x . Allergy: European Journal of Allergy and Clinical Immunology
Analysis of glucose metabolism in farmed European sea bass (Dicentrarchus labrax L.) using deuterated water
Viegas, I.; Mendes, V.M.; Leston, S.; Jarak, I.; Carvalho, R.A.; Pardal, M.Â.; Manadas, B.; Jones, J.G., 2011. Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology. 341 - 347. 3. 160. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80052079316&partnerID=MN8TOARS . 10.1016/j.cbpa.2011.06.029 . Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology
Proteomic analysis of an interactome for long-form AMPA receptor subunits
Santos, S.D.; Manadas, B.; Duarte, C.B.; Carvalho, A.L., 2010. Journal of Proteome Research. 1670 - 1682. 4. 9. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77950666645&partnerID=MN8TOARS . 10.1021/pr900766r . Journal of Proteome Research
Peptide fractionation in proteomics approaches
Manadas, B.; Mendes, V.M.; English, J.; Dunn, M.J., 2010. Expert Review of Proteomics. 655 - 663. 5. 7. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77958550083&partnerID=MN8TOARS . 10.1586/epr.10.46 . Expert Review of Proteomics
BDNF-induced changes in the expression of the translation machinery in hippocampal neurons: Protein levels and dendritic mRNA
Manadas, B.; Santos, A.R.; Szabadfi, K.; Gomes, J.R.; Garbis, S.D.; Fountoulakis, M.; Duarte, C.B., 2009. Journal of Proteome Research. 4536 - 4552. 10. 8. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-70349976976&partnerID=MN8TOARS . 10.1021/pr900366x . Journal of Proteome Research
Comparative analysis of OFFGel, strong cation exchange with pH gradient, and RP at high pH for first-dimensional separation of peptides from a membrane-enriched protein fraction
Manadas, B.; English, J.A.; Wynne, K.J.; Cotter, D.R.; Dunn, M.J., 2009. Proteomics. 5194 - 5198. 22. 9. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-70949086044&partnerID=MN8TOARS . 10.1002/pmic.200900349 . Proteomics
Critical roles for a genetic code alteration in the evolution of the genus Candida
Silva, R.M.; Paredes, J.A.; Moura, G.R.; Manadas, B.; Lima-Costa, T.; Rocha, R.; Miranda, I.; et al, 2007. EMBO Journal. 4555 - 4565. 21. 26. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-35648984625&partnerID=MN8TOARS . 10.1038/sj.emboj.7601876 . EMBO Journal
Sample sonication after trichloroacetic acid precipitation increases protein recovery from cultured hippocampal neurons, and improves resolution and reproducibility in two-dimensional gel electrophoresis
Manadas, B.J.; Vougas, K.; Fountoulakis, M.; Duarte, C.B.; Manadas, Bruno J.; Vougas, Konstantinos; Fountoulakis, Michael; Duarte, Carlos B., 2006. Electrophoresis. 1825 - 1831. 9. 27. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33646590654&partnerID=MN8TOARS . 10.1002/elps.200500757 . Electrophoresis
Neuroprotection by BDNF against glutamate-induced apoptotic cell death is mediated by ERK and PI3-kinase pathways
Almeida, R.D.; Manadas, B.J.; Melo, C.V.; Gomes, J.R.; Mendes, C.S.; Grãos, M.M.; Carvalho, R.F.; Carvalho, A.P.; Duarte, C.B., 2005. Cell Death and Differentiation. 1329 - 1343. 10. 12. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-27144508812&partnerID=MN8TOARS . 10.1038/sj.cdd.4401662 . Cell Death and Differentiation
Intracellular signaling mechanisms in photodynamic therapy
Almeida, R.D.; Manadas, B.J.; Carvalho, A.P.; Duarte, C.B.; Almeida, Ramiro D.; Manadas, Bruno J.; Carvalho, Arsélio P.; Duarte, Carlos B., 2004. Biochimica et Biophysica Acta - Reviews on Cancer. 59 - 86. 2. 1704. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-4444265338&partnerID=MN8TOARS . 10.1016/j.bbcan.2004.05.003 . Biochimica et Biophysica Acta - Reviews on Cancer
5 115 out of 115 Publications
PORTUGUESE PATENT: Device for the Isolation of Cells from Tissue Explants
Device to isolate adherent cells from tissue explants, using a non-enzymatic method Improvements: - design allows the distribution of tissue fragments within pre-determined positions and immobilises them between the device and the cell growth area of a tissue culture container - tissue fragments are immobilized throughout the time in culture, favouring cell migration from the explants to the tissue culture container Application of the device for improving the isolation of cells from tissue explants
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