Catarina Sofia Oliveira Miranda

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Researcher

Affiliation

Center for Neuroscience and Cell Biology (CNC), University of Coimbra (UC); Institute of Interdisciplinary Research from University of Coimbra (iiiUC)

Publications

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Information about journal articles, updated at 26-06-2022, from platform CIÊNCIAVITAE.

Cerebellar morphometric and spectroscopic biomarkers for Machado-Joseph Disease.

Miranda CO*, Acta Neuropathologica Communications. Accepted for publication on February 9, 2022. . 2022. 10.1186/s40478-022-01329-4 . Acta Neuropathologica Communications. Accepted for publication on February 9, 2022.

Highly Porous Composite Scaffolds Endowed with Antibacterial Activity for Multifunctional Grafts in Bone Repair

Neto, Ana S.; Pereira, Patrícia; Fonseca, Ana C.; Dias, Carla; Almeida, Mariana C.; Barros, Inês; Miranda, Catarina O.; et al, Polymers. 24. 13. 2021. http://dx.doi.org/10.3390/polym13244378 . 10.3390/polym13244378 . Polymers

Cerebellar morphometric and spectroscopic biomarkers of Machado-Joseph Disease correlate with motor behaviour in a transgenic mouse model and show similar profiles in human patients. UNDER REVISION

Miranda, Catarina; Nobre, Rui Jorge; Paiva, Vitor Hugo; João Duarte; Castelhano, João; Petrella, Lorena; Sereno, José; et al, 2021. under revision

Mesenchymal stem cells for lysosomal storage and polyglutamine disorders: Possible shared mechanisms

Catarina Miranda, European Journal of Clinical Investigation. 2021. https://doi.org/10.1111/eci.13707 . 10.1111/eci.13707 . European Journal of Clinical Investigation

Blood-brain barrier (BBB) disruption is a shared feature for several neurodegenerative diseases

Oliveira Miranda, C.; Duarte Lobo, D.; Jorge Nobre, R.; Gonzaga, D.; Ines Barros, M.; Ines Martins, M.; Castelhano, J.; et al, European Journal of Clinical Investigation. 2021. https://publons.com/publon/49564552/ . European Journal of Clinical Investigation

The blood-brain barrier is disrupted in Machado-Joseph disease/spinocerebellar ataxia type 3: evidence from transgenic mice and human post-mortem samples

Duarte Lobo, Diana; Nobre, Rui Jorge; Oliveira Miranda, Catarina; Pereira, Dina; Castelhano, João; Sereno, José; Koeppen, Arnulf; Castelo-Branco, Miguel; Pereira de Almeida, Luís, Acta Neuropathologica Communications. 1. 8. 2020. http://dx.doi.org/10.1186/s40478-020-00955-0 . 10.1186/s40478-020-00955-0 . Acta Neuropathologica Communications

Allele-Specific AAV-Based Silencing of Mutant Ataxin-3 Alleviates Neuropathology and Motor Deficits in Spinocerebellar Ataxia Type 3

Nobre, Rui Jorge; Saraiva, Joana; Santana, Magda; Fusco, Clelia; Paixao, Susana; Miranda, Catarina; Petrella, Lorena; et al, Molecular Therapy. 2020. https://publons.com/publon/39930949/ . Molecular Therapy

Mesenchymal Stromal Cells’ Therapy for Polyglutamine Disorders: Where Do We Stand and Where Should We Go?

Barros, Inês; Marcelo, Adriana; Silva, Teresa P.; Barata, João; Rufino-Ramos, David; Pereira de Almeida, Luís; Miranda, Catarina O., Frontiers in Cellular Neuroscience. 14. 2020. http://dx.doi.org/10.3389/fncel.2020.584277 . 10.3389/fncel.2020.584277 . Frontiers in Cellular Neuroscience

Mesenchymal stromal cells to fight SARS-CoV-2: Taking advantage of a pleiotropic therapy

Barros, Inês; Silva, António; de Almeida, Luís Pereira; Miranda, Catarina Oliveira, Cytokine & Growth Factor Reviews. 2020. http://dx.doi.org/10.1016/j.cytogfr.2020.12.002 . 10.1016/j.cytogfr.2020.12.002 . Cytokine & Growth Factor Reviews

CRISPR-Cas9-Mediated Pre-Transcriptional Silencing of Mutant ATXN3 Decreases Motor Impairments of an In Vivo Machado-Joseph Disease Model

Matos, Carlos; Pena, Frederico; Conceicao, Andre; Lopes, Sara; Duarte, Sonia; Miranda, Catarina; de Almeida, Luis Pereira, Molecular Therapy. 2019. https://publons.com/publon/21742534/ . Molecular Therapy

CRISPR interference-mediated silencing of mutant ATXN3 decreases motor impairments of an in vivo Machado-Joseph disease model

Matos, Carlos; Pena, Frederico; Conceicao, Andre; Lopes, Sara; Duarte, Sonia; Miranda, Catarina; de Almeida, Luis Pereira, European Journal of Clinical Investigation. 2019. https://publons.com/publon/28984641/ . European Journal of Clinical Investigation

A miRNA-based gene therapy approach to knock-down mutant ATXN3: Alleviation of Machado-Joseph disease phenotype in two mouse models upon two routes of administration

Nobre, Rui Jorge; Saraiva, Joana; Fusco, Clelia; Paixao, Susana; Santana, Magda; Miranda, Catarina; Petrella, Lorena; et al, European Journal of Clinical Investigation. 2019. https://publons.com/publon/39930960/ . European Journal of Clinical Investigation

Autophagy activation induced by let-7 microRNA overexpression counteracts disease phenotype in Machado-Joseph disease mouse models

Sónia Duarte; Beatriz Estremores; Janete Cunha-Santos; Catarina Miranda; João Barata; Albert La Spada; Luis De Almeida, Frontiers in Cellular Neuroscience. 2019. https://publons.com/publon/49522345/ . 10.3389/CONF.FNCEL.2019.01.00026 . Frontiers in Cellular Neuroscience

Repeated transplantation of mesenchymal stromal cells in Machado-Joseph disease/Spinocerebellar ataxia type-3 mice can sustainably alleviate phenotypic symptoms and ameliorations can be monitored through magnetic resonance spectroscopy

Miranda, Catarina Oliveira; Marcelo, Adriana; Silva, Teresa Pereira; Barata, Joao; Vasconcelos-Ferreira, Ana; Pereira, Dina; Duarte, Sonia; et al, European Journal of Clinical Investigation. 2019. https://publons.com/publon/28984639/ . European Journal of Clinical Investigation

Non-invasive and allele-specific silencing therapy for Polyglutamine disorders: the case of Machado-Joseph disease/Spinocerebellar ataxia type 3

Rui Nobre; Joana Saraiva; Susana Paixão; Cellia Fusco; Magda Santana; Catarina Miranda; Lorena Petrella; et al, Frontiers in Cellular Neuroscience. 2019. https://publons.com/publon/49522350/ . 10.3389/CONF.FNCEL.2019.01.00007 . Frontiers in Cellular Neuroscience

Upregulation of let-7 microrna in mouse models of Machado-Joseph disease ameliorates neuropathology and motor phenotype

Duarte, Sonia Patricia; Estremores, Beatriz; Cunha-Santos, Janete; Miranda, Catarina; Barata, Joao; La Spada, Albert; de Almeida, Luis Pereira, European Journal of Clinical Investigation. 2019. https://publons.com/publon/28984643/ . European Journal of Clinical Investigation

Blood-brain barrier dysfunction as a neuropathological feature in Machado-Joseph Disease: results from human and mouse samples

Diana Lobo; Rui Nobre; Catarina Miranda; Dina Pereira; João Castelhano; José Sereno; Miguel Castelo-Branco; Luís De Almeida, Frontiers in Cellular Neuroscience. 2019. https://publons.com/publon/49522352/ . 10.3389/CONF.FNCEL.2019.01.00022 . Frontiers in Cellular Neuroscience

Repeated Mesenchymal Stromal Cell Treatment Sustainably Alleviates Machado-Joseph Disease

Miranda, Catarina Oliveira; Marcelo, Adriana; Silva, Teresa Pereira; Barata, Joao; Vasconcelos-Ferreira, Ana; Pereira, Dina; Nobrega, Clevio; et al, Molecular Therapy. 2018. https://publons.com/publon/17779112/ . 10.1016/J.YMTHE.2018.07.007 . Molecular Therapy

Repeated Mesenchymal Stromal Cell Treatment Sustainably Alleviates Machado-Joseph Disease

Oliveira Miranda, Catarina; Marcelo, Adriana; Silva, Teresa Pereira; Barata, João; Vasconcelos-Ferreira, Ana; Pereira, Dina; Nóbrega, Clévio; et al, Molecular Therapy. 2131 - 2151. 9. 26. 2018. http://dx.doi.org/10.1016/j.ymthe.2018.07.007 . 10.1016/j.ymthe.2018.07.007 . Molecular Therapy

Early axonal loss accompanied by impaired endocytosis, abnormal axonal transport, and decreased microtubule stability occur in the model of Krabbe's disease

Teixeira, Carla Andreia; Miranda, Catarina Oliveira; Sousa, Vera Filipe; Santos, Telma Emanuela; Malheiro, Ana Rita; Solomon, Melani; Maegawa, Gustavo H.; Brites, Pedro; Sousa, Mónica Mendes, Neurobiology of Disease. 92 - 103. 66. 2014. http://dx.doi.org/10.1016/j.nbd.2014.02.012 . 10.1016/j.nbd.2014.02.012 . Neurobiology of Disease

Early axonal loss accompanied by impaired endocytosis, abnormal axonal transport, and decreased microtubule stability occur in the model of Krabbe's disease

Teixeira, Carla Andreia; Miranda, Catarina Oliveira; Sousa, Vera Filipe; Santos, Telma Emanuela; Malheiro, Ana Rita; Solomon, Melani; Maegawa, Gustavo H.; Brites, Pedro; Sousa, Monica Mendes, Neurobiology of Disease. 2014. https://publons.com/publon/11055779/ . 10.1016/J.NBD2014.02.012 . Neurobiology of Disease

Advances and pitfalls of cell therapy in metabolic leukodystrophies

Miranda, C.O.; Brites, P.; Sousa, M.M.; Teixeira, C.A., Cell Transplantation. 189 - 204. 2. 22. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874371497&partnerID=MN8TOARS . 10.3727/096368912X656117 . Cell Transplantation

Primary Bone Marrow Mesenchymal Stromal Cells Rescue the Axonal Phenotype of Twitcher Mice.

Miranda CO; Teixeira CA; Sousa VF; Santos TE; Liz MA; Marques AM; Pinto-do-O P; Sousa MM, 2013. http://europepmc.org/abstract/med/23809254 . 10.3727/096368913X669752 .

Expression of stem cell markers: OCT4, KIT, ITGA6, and ITGB1 in the male germinal epithelium

Sá, Rosália; Miranda, Catarina; Carvalho, Filipa; Barros, Alberto; Sousa, Mário, Systems Biology in Reproductive Medicine. 233 - 243. 5. 59. 2013. http://dx.doi.org/10.3109/19396368.2013.804964 . 10.3109/19396368.2013.804964 . Systems Biology in Reproductive Medicine

Biomarkers Expression in Human Seminiferous Epithelium

Sá, R.; Miranda, C; Leite, C.; Malheiro, I.; Carvalho, F.; Silva, J.; Barros, A.; Sousa, M.; Miranda, C., Microscopy and Microanalysis. 15 - 16. S5. 18. 2012. http://dx.doi.org/10.1017/s1431927612012731 . 10.1017/s1431927612012731 . Microscopy and Microanalysis

Systemic Delivery of Bone Marrow-Derived Mesenchymal Stromal Cells Diminishes Neuropathology in a Mouse Model of Krabbe's Disease

Miranda, Catarina Oliveira; Teixeira, Carla Andreia; Liz, Marcia Almeida; Sousa, Vera Filipe; Franquinho, Filipa; Forte, Giancarlo; Di Nardo, Paolo; Pinto-Do-O, Perpetua; Sousa, Monica Mendes, Stem Cells. 2011. https://publons.com/publon/5164241/ . 10.1002/STEM.724 . Stem Cells

Systemic Delivery of Bone Marrow-Derived Mesenchymal Stromal Cells Diminishes Neuropathology in a Mouse Model of Krabbe's Disease

Miranda, Catarina Oliveira; Teixeira, Carla Andreia; Liz, Márcia Almeida; Sousa, Vera Filipe; Franquinho, Filipa; Forte, Giancarlo; Di Nardo, Paolo; Pinto-Do-Ó, Perpétua; Sousa, Mónica Mendes, STEM CELLS. 1738 - 1751. 11. 29. 2011. http://dx.doi.org/10.1002/stem.724 . 10.1002/stem.724 . STEM CELLS

All projects

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Information of exclusive responsibility of the researcher 26-06-2022 , from platform CIÊNCIAVITAE.

2021/03/01 -

Are mesenchymal stromal cells’ able to alleviate blood-brain-barrier impairments in Machado- Joseph disease mice?

SUBMITTED

Principal investigator

National Ataxia Foundation

Funders: AFM-Téléthon

2021/03/01 -

Are mesenchymal stromal cells’ able to alleviate blood-brain-barrier impairments in Machado- Joseph disease mice?

SUBMITTED

Principal investigator

National Ataxia Foundation

Funders: AFM-Téléthon

2021/08/01 - 2022/03/31

Multiomics approach for studying mitochondrial dysfunction in aging to harness stem cell therapy (20K €)

NA

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Japan Agency for Medical Research and Development (AMED)

2020 - 2024

From mesenchymal stromal cells to its secretome: Clarifying the mechanism of alleviation of Machado-Joseph disease

SFRH/BD/148877/2019

Supervisor

Funders: Fundação para a Ciência e a Tecnologia

2019 - 2021

MESENCHYMAL STEM CELLS FOR MACHADO-JOSEPH DISEASE THERAPY

position 6 of NT CNC 2018.01-35

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Universidade de Coimbra Centro de Neurociências e Biologia Celular

2018/07 - 2021/07

Role of microRNA deregulation in Machado-Joseph Disease: On the development of a microRNA-based therapeutic strategy

PTDC/MED-NEU/32309/2017

Researcher

Funders: Fundação para a Ciência e a Tecnologia

2017 - 2020

BrainHealth 2020 - Detecção Precoce, Neuro-modulação e Terapias Avançadas para Neuropatologias.

CENTRO-01-0145-FEDER-000008

Researcher

Funders: Funding Agency: Centro2020 - Programa Operacional Centro 2020 (FEDER/FSE) (BrainHealth 2020 CENTRO-01-0145-FEDER-000008)

2016/01 - 2018/12

Gene repair and repression strategies to alleviate Machado-Joseph disease

Provided by PTCRIS: 138667

Researcher

Funders: Fundação para a Ciência e a Tecnologia

2015/01 - 2017/12

CNC. IBILI

Provided by PTCRIS: 147358

Researcher

Funders: Fundação para a Ciência e a Tecnologia

2013/02/01 - 2019

Mesenchymal Stem Cells for Machado-Joseph Disease

SFRH/BPD/87732/2012

Post-doc Fellow

Funders: Fundação para a Ciência e a Tecnologia

2012/01 - 2015/07

Dissecting the pathogenesis of Machado-Joseph disease in a new human disease model derived from induced pluripotent stem cells

Provided by PTCRIS: 116512

Research Fellow

Funders: Fundação para a Ciência e a Tecnologia

2011/02 - 2014/03

Dissecting nerve regeneration and the neuritogenic activity of TTR.

Provided by PTCRIS: 111761

Research Fellow

Funders: Fundação para a Ciência e a Tecnologia

2007 - 2011

Evaluation of Cellular Therapy in Leukodystrophies with Peripheral Nervous System Demyelination

SFRH/BD/29768/2006

PhD Student Fellow

Funders: Fundação para a Ciência e a Tecnologia

2007/11 - 2010/10

Search for the molecular basis of transthyretin involvement in the biology of the nervous system.

grant.Provided by PTCRIS: 64437

Researcher

Funders: Fundação para a Ciência e a Tecnologia

2006/10 - 2007/03

Towards the establishment of cell-based therapy for repairing cardiac-injury: characterization, purification and functional analysis of potential therapeutic-beneficial cell-subsets.

PTDC/SAU-OSM/68473/2006

Researcher

Funders: Fundação para a Ciência e a Tecnologia

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