Cláudia Fragão Pereira

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Researcher

Overview

C Pereira is Biochemist (1991), Master in Cell Biology (1994) and received, in 2000, her PhD in Cell Biology from the Faculty of Sciences and Technology, University of Coimbra (UC), Portugal. Presently, she is Investigator (with tenure) at the Faculty of Medicine at UC (FMUC), and is Principal Investigator (PI) of the research line Endoplasmic Reticulum (ER) Stress Response and ER-Mitochondria Axis at the Cell Signaling and Metabolism group from the Center for Neuroscience and Cell Biology (CNC-UC), which integrates the Center for Innovative Biomedicine and Biotechnology (CIBB) at UC. The specific aims of her research line are to: 1) clarify the biological basis of neuropsychiatric diseases, namely neurodegenerative disorders (Alzheimer disease) and mental disorders (bipolar disorder and schizophrenia), focusing on the deregulation of cellular stress responses, with a special focus on ER and mitochondria stress and on the close ER-mitochondria contacts (MAMs), its metabolic and immune implications; 2) explore the preventive and therapeutic potential of natural resources. For these purposes, both in vitro (cell lines and primary cell cultures) and in vivo experimental models (transgenic mice) and also human biological samples (blood samples and skin-derived fibroblasts) are used due to a long-lasting and fruitful collaboration with the Neurology and Psychiatry Departments from the Coimbra University Hospital (CHUC). Due to her participation in several funded projects, either as PI/co-PI or as team member, C Pereira published more than 80 peer-reviewed papers, the majority in international quartile 1 (Q1) journals. In addition, she is inventor of 3 patents, 2 presently under evaluation, demonstrating the relevance of her research in knowledge transfer promotion. The scientific impact of her research is reflected in the H index (39) and high number of citations (~ 4500) (WoScc). In 2004 C Pereira was awarded with the LOréal For Women in Science Prize (1st edition). Since then, she is member of the Evaluation Board of this L'Oréal Portugal/UNESCO/FCT award and was invited to participate in the 2021 edition of Women in Science book that brings together portraits of Portuguese female researchers. She supervised several PhD (8 concluded, 2 ongoing) and Master (>20 concluded) students, research fellows, UC 1st cycle and ERASMUS students. She is actively enrolled in 1st cycle studies and in Master and PhD programs at UC. She is Editor of scientific journals as well as reviewer for several peer-reviewed international journals, and has integrated the evaluation board of funding agencies such as ARS (France) and FCT (Portugal). She was invited speaker and/or co-authored more than 50 oral and 100 poster communications in (inter)national scientific meetings and was also enrolled in the organization of several scientific meetings. She actively participated in several science outreach projects and activities, namely "Ciencia Viva during Summer Holidays" and "Brain Awareness Week", and was invited to participate in events in media and broad end-users (TV, radio, newspapers, social networks, institutional webpage). In addition to her research and teaching duties, C Pereira is also enrolled in FMUC management as member of the Faculty Assembly, and is presently member of the Board of Directors of CNC-UC. C Pereira is volunteer at the "Machado de Castro" Museum (Coimbra, Portugal) in the project "EU no MusEU" (collaboration with the Alzheimer Portugal Association).

Affiliation

Center for Innovative Biomedicine and Biotechnology, Center for Neuroscience and Cell Biology & Faculty of Medicine, University of Coimbra

Publications

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Information about journal articles, updated at 19-05-2024, from platform CIÊNCIAVITAE.

Mapping the lipidome in mitochondria-associated membranes (MAMs) in an in vitro model of Alzheimer's disease

Tânia Fernandes; Tânia Melo; Tiago Conde; Bruna Neves; Pedro Domingues; Rosa Resende; Cláudia F. Pereira; Paula I. Moreira; Maria Rosário Domingues, Journal of Neurochemistry. 2024. https://doi.org/10.1111/jnc.16072 . 10.1111/jnc.16072 . Journal of Neurochemistry

Effect of Ferulago lutea (Poir.) Grande Essential Oil on Molecular Hallmarks of Skin Aging

Jorge M. Alves-Silva; Patrícia Moreira; Carlos Cavaleiro; Cláudia Pereira; Maria Teresa Cruz; Lígia Salgueiro, Plants. 2023. https://doi.org/10.3390/plants12213741 . 10.3390/plants12213741 . Plants

Exploiting the Integrated Valorization of Eucalyptus globulus Leaves: Chemical Composition and Biological Potential of the Lipophilic Fraction before and after Hydrodistillation

Cátia. S. D. Oliveira; Patrícia Moreira; Maria T. Cruz; Cláudia M. F. Pereira; Artur M. S. Silva; Sónia A. O. Santos; Armando J. D. Silvestre, International Journal of Molecular Sciences. 2023. https://doi.org/10.3390/ijms24076226 . 10.3390/ijms24076226 . International Journal of Molecular Sciences

An integrated green process for the extraction of triterpenic acids from Eucalyptus globulus leaves after hydrodistillation

Cátia S. D. Oliveira; Patrícia Moreira; Maria T. Cruz; Cláudia M. F. Pereira; Alexandre Gaspar; Carlos Pascoal Neto; Paula C. R. O. Pinto; et al, RSC Sustainability. 2023. https://doi.org/10.1039/D3SU00076A . 10.1039/D3SU00076A . RSC Sustainability

A Perspective on the Link between Mitochondria-Associated Membranes (MAMs) and Lipid Droplets Metabolism in Neurodegenerative Diseases

Tânia Fernandes; M. Rosário Domingues; Paula I. Moreira; Cláudia F. Pereira, Biology. 2023. https://doi.org/10.3390/biology12030414 . 10.3390/biology12030414 . Biology

Mitochondria Fusion upon SERCA Inhibition Prevents Activation of the NLRP3 Inflammasome in Human Monocytes

Pereira, Ana Catarina; Madeira, Nuno; Morais, Sofia; Macedo, António; Cruz, Maria Teresa; Pereira, Cláudia M. F., Cells. 3. 11. 2022. http://dx.doi.org/10.3390/cells11030433 . 10.3390/cells11030433 . accepted Cells

Exploring the antioxidant, anti-inflammatory and antiallergic potential of Brazilian propolis in monocytes

Conte, Fernanda Lopes; Pereira, Ana Catarina; Brites, Gonçalo; Ferreira, Isabel; Silva, Ana Cristina; Sebastião, Ana Isabel; Matos, Patrícia; et al, Phytomedicine Plus. 2. 2. 2022. http://dx.doi.org/10.1016/j.phyplu.2022.100231 . 10.1016/j.phyplu.2022.100231 . Phytomedicine Plus

Bioactive Bacterial Nanocellulose Membranes Enriched with Eucalyptus globulus Labill. Leaves Aqueous Extract for Anti-Aging Skin Care Applications

Almeida, Tânia; Moreira, Patrícia; Sousa, Fábio J.; Pereira, Cláudia; Silvestre, Armando J. D.; Vilela, Carla; Freire, Carmen S. R., Materials. 5. 15. 2022. http://dx.doi.org/10.3390/ma15051982 . 10.3390/ma15051982 . published Materials

Chemical Composition and Effect against Skin Alterations of Bioactive Extracts Obtained by the Hydrodistillation of <i>Eucalyptus globulus</i> Leaves

Patrícia Moreira; Fábio J. Sousa; Patrícia Matos; Brites, G; Maria José Gonçalves; Carlos Cavaleiro; Artur Figueirinha; et al, Pharmaceutics. 2022. https://www.mdpi.com/1999-4923/14/3/561 . 10.3390/pharmaceutics14030561 . Pharmaceutics

ER-mitochondria communication is involved in NLRP3 inflammasome activation under stress conditions in the innate immune system

Sofia mori, Cellular and Molecular Life Sciences. 2022. accepted Cellular and Molecular Life Sciences

Forest Biomass as a Promising Source of Bioactive Essential Oil and Phenolic Compounds for Alzheimer’s Disease Therapy

Patrícia Moreira; Patrícia Matos; Artur Figueirinha; Lígia Salgueiro; Maria Teresa Batista; Pedro Costa Branco; Maria Teresa Cruz; Cláudia Fragão Pereira, International Journal of Molecular Sciences. 2022. https://doi.org/10.3390/ijms23158812 . 10.3390/ijms23158812 . International Journal of Molecular Sciences

ER-Mitochondria contacts modulate ROS-mediated signaling and oxidative stress in brain disorders: the key role of Sigma-1 receptor.

Resende, Rosa; Fernandes, Tânia; Pereira, Ana Catarina; Marques, Ana Patrícia; Pereira, Cláudia Fragão, Antioxidants & Redox Signaling. 2022. http://dx.doi.org/10.1089/ars.2020.8231 . 10.1089/ars.2020.8231 . published Antioxidants & Redox Signaling

Synergistic hypoglycemic and hypolipidemic effects of ¿-3 and ¿-6 fatty acids from Indian flax and sesame seed oils in streptozotocin-induced diabetic rats

Sunil Chikkalakshmipura Gurumallu; Tareq N. AlRamadneh; Halugudde Nagaraja Sarjan; Ashwini Bhaskar; Cláudia Maria Fragão Pereira; Rajesha Javaraiah, Phytomedicine Plus. 2022. https://doi.org/10.1016/j.phyplu.2022.100284 . 10.1016/j.phyplu.2022.100284 . Phytomedicine Plus

Therapies for Alzheimer’s disease: a metabolic perspective

Domingues, Raquel; Pereira, Claúdia; Cruz, Maria Teresa; Silva, Ana, Molecular Genetics and Metabolism. 21. S1096-71. 2021. http://dx.doi.org/10.1016/j.ymgme.2021.01.011 . 10.1016/j.ymgme.2021.01.011 . published Molecular Genetics and Metabolism

Physical and biochemical alterations in endoplasmic reticulum-mitochondria contacts in an Alzheimer's disease in vitro model

Fernandes, Tânia; Resende, Rosa; Domingues, Maria R.; Paula I. Moreira; Pereira, Cláudia Fragão, European Journal of Clinical Investigation. S1. 51. 2021. http://dx.doi.org/10.1111/eci.13567 . published European Journal of Clinical Investigation

Chemical characterization and bioactive potential of Artemisia campestris L. subsp. maritima (DC) Arcang. essential oil and hydrodistillation residual water

Rocha, Maria Inês; Gonçalves, Maria José; Cavaleiro, Carlos; Cruz, Maria Teresa; Pereira, Cláudia; Moreira, Patrícia; Salgueiro, Lígia; Figueirinha, Artur, Journal of Ethnopharmacology. 276. 2021. http://dx.doi.org/10.1016/j.jep.2021.114146 . 10.1016/j.jep.2021.114146 . published Journal of Ethnopharmacology

Structural and Functional Alterations in Mitochondria-Associated Membranes (MAMs) and in Mitochondria Activate Stress Response Mechanisms in an In Vitro Model of Alzheimers Disease

Fernandes, Tânia; Resende, Rosa; Silva, Diana F.; Marques, Ana P.; Santos, Armanda E.; Cardoso, Sandra M.; Domingues, M. Rosário; Moreira, Paula I.; Pereira, Cláudia F., Biomedicines. 8. 9. 2021. http://dx.doi.org/10.3390/biomedicines9080881 . 10.3390/biomedicines9080881 . published Biomedicines

Mitochondrial Alterations in Fibroblasts of Early Stage Bipolar Disorder Patients

Ana P. Marques; Rosa Resende; Diana F. Silva; Mariana Batista; Daniela Pereira; Brigite Wildenberg; Sofia Morais; et al, Biomedicines. 2021. https://www.mdpi.com/2227-9059/9/5/522 . 10.3390/biomedicines9050522 . Biomedicines

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Pereira, Cláudia, Autophagy. 1 - 382. 8. 2021. published Autophagy

Inflammation in Bipolar Disorder (BD): Identification of new therapeutic targets

Pereira, Ana Catarina; Oliveira, Joana; Silva, Sónia; Madeira, Nuno; Pereira, Cláudia M.F.; Cruz, Maria T., Pharmacological Research. 163. 2021. http://dx.doi.org/10.1016/j.phrs.2020.105325 . 10.1016/j.phrs.2020.105325 . published Pharmacological Research

Characterization and Cytotoxicity Assessment of the Lipophilic Fractions of Different Morphological Parts of Acacia dealbata

Cátia S. D. Oliveira; Patrícia Moreira; Judite Resende; Maria T. Cruz; Cláudia M. F. Pereira; Artur M. S. Silva; Sónia A. O. Santos; Armando J. D. Silvestre, International Journal of Molecular Sciences. 1814 - 1830. 5. 21. 2020. https://doi.org/10.3390/ijms21051814 . 10.3390/ijms21051814 . International Journal of Molecular Sciences

Calcium Modulation, Anti-Oxidant and Anti-Inflammatory Effect of Skin Allergens Targeting the Nrf2 Signaling Pathway in Alzheimer’s Disease Cellular Models

Silva, Ana; Pereira, Marta; Carrascal, Mylène A.; Brites, Gonçalo; Neves, Bruno; Moreira, Patrícia; Resende, Rosa; et al, International Journal of Molecular Sciences. 20. 21. 2020. http://dx.doi.org/10.3390/ijms21207791 . 10.3390/ijms21207791 . International Journal of Molecular Sciences

Calcium Signaling in Aging and Neurodegenerative Diseases 2019

Luísa Cortes; João Malva; Ana Cristina Rego; Cláudia F. Pereira, International Journal of Molecular Sciences. 1125 - 1125. 3. 21. 2020. https://doi.org/10.3390/ijms21031125 . 10.3390/ijms21031125 . International Journal of Molecular Sciences

In vitro evaluation of potential benefits of a silica-rich thermal water (Monfortinho Thermal Water) in hyperkeratotic skin conditions

Oliveira, Ana Sofia; Vaz, Cátia Vicente; Silva, Ana; Correia, Sara; Ferreira, Raquel; Breitenfeld, Luiza; Martinez-de-Oliveira, José; et al, International Journal of Biometeorology. 1957 - 1968. 11. 64. 2020. http://dx.doi.org/10.1007/s00484-020-01986-x . 10.1007/s00484-020-01986-x . published International Journal of Biometeorology

New BACE1 Chimeric Peptide Inhibitors Selectively Prevent AßPPß Cleavage Decreasing Amyloid-ß Production and Accumulation in Alzheimers Disease Models

Resende, Rosa; Ferreira-Marques, Marisa; Moreira, Patrícia; Coimbra, Judite R.M.; Baptista, Salete J.; Isidoro, Ciro; Salvador, Jorge A.R.; et al, Journal of Alzheimer's Disease. 1317 - 1337. 6. 70. 2020. http://dx.doi.org/10.3233/jad-200381 . 10.3233/jad-200381 . published Journal of Alzheimer's Disease

Mitochondria, endoplasmic reticulum and innate immune dysfunction in mood disorders: Do Mitochondria-Associated Membranes (MAMs) play a role?

R. Resende; T. Fernandes; A.C. Pereira; J. De Pascale; A.P. Marques; P. Oliveira; S. Morais; et al, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 165752 - 165752. 6. 1866. 2020. https://doi.org/10.1016/j.bbadis.2020.165752 . 10.1016/j.bbadis.2020.165752 . published Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Anti-inflammatory potential of Portuguese thermal waters

Silva, A.; Oliveira, A. S.; Vaz, C. V.; Correia, S.; Ferreira, R.; Breitenfeld, L.; Martinez-de-Oliveira, J.; et al, Scientific Reports. 1. 10. 2020. http://dx.doi.org/10.1038/s41598-020-79394-9 . 10.1038/s41598-020-79394-9 . published Scientific Reports

Is Alzheimer’s disease an inflammasomopathy?

Pereira, Claudia F.; Santos, Armanda E.; Moreira, Paula I.; Pereira, Ana Catarina; Sousa, Fabio J.; Cardoso, Sandra M.; Cruz, M. Teresa, Ageing Research Reviews. 56. 2019. http://dx.doi.org/10.1016/j.arr.2019.100966 . 10.1016/j.arr.2019.100966 . Ageing Research Reviews

Chemical signature and antimicrobial activity of Central Portuguese Natural Mineral Waters against selected skin pathogens

Oliveira, Ana Sofia; Vaz, Cátia Vicente; Silva, Ana; Ferreira, Sandra Saraiva; Correia, Sara; Ferreira, Raquel; Breitenfeld, Luiza; et al, Environmental Geochemistry and Health. 2019. http://dx.doi.org/10.1007/s10653-019-00473-6 . 10.1007/s10653-019-00473-6 . published Environmental Geochemistry and Health

The Eighth ECS Workshop on “Calcium Signaling in Aging and Neurodegenerative Diseases”

Jan Parys; C Pereira; Carlos Villalobos, International Journal of Molecular Sciences. 2019. https://www.mdpi.com/1422-0067/20/24/6263 . 10.3390/ijms20246263 . International Journal of Molecular Sciences

Highlights in BACE1 Inhibitors for Alzheimer's Disease Treatment

Coimbra, Judite R. M.; Marques, Daniela F. F.; Baptista, Salete J.; Pereira, Cláudia M. F.; Moreira, Paula I.; Dinis, Teresa C. P.; Santos, Armanda E.; Salvador, Jorge A. R., Frontiers in Chemistry. 6. 2018. http://dx.doi.org/10.3389/fchem.2018.00178 . 10.3389/fchem.2018.00178 . published Frontiers in Chemistry

When, where and how: mitochondrial multifaceted dysfunction in Alzheimer's disease

Oliveira, C. R.; Pereira, C.; Rego, A. C.; Moreira, P. I.; Cardoso, S., European Journal of Clinical Investigation. 24 - 25. 47. 2017. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000412099900035&KeyUID=WOS:000412099900035 . European Journal of Clinical Investigation

Phosphatase 2A Inhibition Affects Endoplasmic Reticulum and Mitochondria Homeostasis Via Cytoskeletal Alterations in Brain Endothelial Cells

Placido, Ana I.; Pereira, Claudia M. F.; Correira, Sonia C.; Carvalho, Cristina; Oliveira, Catarina R.; Moreira, Paula I., Molecular Neurobiology. 154 - 168. 1. 54. 2017. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000392133900014&KeyUID=WOS:000392133900014 . 10.1007/s12035-015-9640-1 . Molecular Neurobiology

Daucus carota subsp gummifer essential oil as a natural source of antifungal and anti-inflammatory drugs

Valente, J.; Zuzarte, M.; Resende, R.; Goncalves, M. J.; Cavaleiro, C.; Pereira, C. F.; Cruz, M. T.; Salgueiro, L., Industrial Crops and Products. 361 - 366. 65. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000349430000046&KeyUID=WOS:000349430000046 . 10.1016/j.indcrop.2014.11.014 . Industrial Crops and Products

Alzheimer's Disease-Related Misfolded Proteins and Dysfunctional Organelles on Autophagy Menu

Correia, Sonia C.; Resende, Rosa; Moreira, Paula I.; Pereira, Claudia M., DNA and Cell Biology. 261 - 273. 4. 34. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000352342300005&KeyUID=WOS:000352342300005 . 10.1089/dna.2014.2757 . DNA and Cell Biology

A beta and NMDAR activation cause mitochondrial dysfunction involving ER calcium release

Ferreira, Ildete Luisa; Ferreiro, Elisabete; Schmidt, Jeannette; Cardoso, Joao M.; Pereira, Claudia M. F.; Carvalho, Ana Luisa; Oliveira, Catarina R.; Cristina Rego, A., Neurobiology of Aging. 680 - 692. 2. 36. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000352454400014&KeyUID=WOS:000352454400014 . 10.1016/j.neurobiolaging.2014.09.006 . Neurobiology of Aging

Oxidative stress involving changes in Nrf2 and ER stress in early stages of Alzheimer's disease

Mota, Sandra I.; Costa, Rui O.; Ferreira, Ildete L.; Santana, Isabel; Caldeira, Gladys L.; Padovano, Carmela; Fonseca, Ana C.; et al, Biochimica Et Biophysica Acta-Molecular Basis of Disease. 1428 - 1441. 7. 1852. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000355715200021&KeyUID=WOS:000355715200021 . 10.1016/j.bbadis.2015.03.015 . Biochimica Et Biophysica Acta-Molecular Basis of Disease

Modulation of Endoplasmic Reticulum Stress: An Opportunity to Prevent Neurodegeneration?

Placido, Ana I.; Pereira, Claudia M. F.; Duarte, Ana I.; Candeias, Emanuel; Correia, Sonia C.; Carvalho, Cristina; Cardoso, Susana; Oliveira, Catarina R.; Moreira, Paula I., Cns & Neurological Disorders-Drug Targets. 518 - 533. 4. 14. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000354179100012&KeyUID=WOS:000354179100012 . 10.2174/1871527314666150429112353 . Cns & Neurological Disorders-Drug Targets

BRI2 ectodomain affects A beta(42) fibrillation and tau truncation in human neuroblastoma cells

Del Campo, M.; Oliveira, C. R.; Scheper, W.; Zwart, R.; Korth, C.; Mueller-Schiffmann, A.; Kostallas, G.; et al, Cellular and Molecular Life Sciences. 1599 - 1611. 8. 72. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000351456000012&KeyUID=WOS:000351456000012 . 10.1007/s00018-014-1769-y . Cellular and Molecular Life Sciences

Enhanced Amyloidogenic Processing of Amyloid Precursor Protein and Cell Death Under Prolonged Endoplasmic Reticulum Stress in Brain Endothelial Cells

Placido, Ana I.; Oliveira, Catarina R.; Moreira, Paula I.; Pereira, Claudia Maria F., Molecular Neurobiology. 571 - 590. 2. 51. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000351311800012&KeyUID=WOS:000351311800012 . 10.1007/s12035-014-8819-1 . Molecular Neurobiology

Bioactivity and safety profile of Daucus carota subsp maximus essential oil

Valente, J.; Resende, R.; Zuzarte, M.; Goncalves, M. J.; Lopes, M. C.; Cavaleiro, C.; Pereira, C.; Salgueiro, L.; Cruz, M. T., Industrial Crops and Products. 218 - 224. 77. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000366065200028&KeyUID=WOS:000366065200028 . 10.1016/j.indcrop.2015.08.037 . Industrial Crops and Products

New promising peptides to inhibit BACE1: evaluation of compound efficiency in cellular and mouse models of Alzheimer’s disease

Resende, Rosa; Pereira, Cláudia; Dinis, Teresa; Santos, Armanda E.; Ferreira-Marques, Marisa, Sinapse. 2015. http://www.geecd.org/images/GEECDFiles/29a_Reuniao_do_GEECD_ResumosSinapse.pdf . published Sinapse

Amyloid-Beta Disrupts Calcium and Redox Homeostasis in Brain Endothelial Cells

Fonseca, Ana Catarina R. G.; Moreira, Paula I.; Oliveira, Catarina R.; Cardoso, Sandra M.; Pinton, Paolo; Pereira, Claudia F., Molecular Neurobiology. 610 - 622. 2. 51. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000351311800015&KeyUID=WOS:000351311800015 . 10.1007/s12035-014-8740-7 . Molecular Neurobiology

Loss of proteostasis induced by amyloid beta peptide in brain endothelial cells

Fonseca, Ana Catarina; Oliveira, Catarina R.; Pereira, Claudia F.; Cardoso, Sandra M., Biochimica Et Biophysica Acta-Molecular Cell Research. 1150 - 1161. 6. 1843. 2014. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000335627900010&KeyUID=WOS:000335627900010 . 10.1016/j.bbamcr.2014.02.016 . Biochimica Et Biophysica Acta-Molecular Cell Research

Protective Effect of Leptin and Ghrelin against Toxicity Induced by Amyloid- beta Oligomers in a Hypothalamic cell Line

Gomes, S.; Martins, I.; Fonseca, A. C. R. G.; Oliveira, C. R.; Resende, R.; Pereira, C. M. F., Journal of Neuroendocrinology. 176 - 185. 3. 26. 2014. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000333329700004&KeyUID=WOS:000333329700004 . 10.1111/jne.12138 . Journal of Neuroendocrinology

The role of endoplasmic reticulum in amyloid precursor protein processing and trafficking: Implications for Alzheimer's disease

Placido, A. I.; Pereira, C. M. F.; Duarte, A. I.; Candeias, E.; Correia, S. C.; Santos, R. X.; Carvalho, C.; et al, Biochimica Et Biophysica Acta-Molecular Basis of Disease. 1444 - 1453. 9. 1842. 2014. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000340975400016&KeyUID=WOS:000340975400016 . 10.1016/j.bbadis.2014.05.003 . Biochimica Et Biophysica Acta-Molecular Basis of Disease

MISFOLDED BRI2 ECTODOMAIN ACTIVATES CRITICAL PATHOLOGICAL PATHWAYS INVOLVED IN EARLY STAGES OF ALZHEIMER'S DISEASE

Campo Milan, Marta Del; Pereira, Cláudia; Scheper, W.; Zwart, R.; Hoozemans, Jeroen; Oliveira, Catarina; Teunissen, Charlotte, Alzheimer's & Dementia. 4. 10. 2014. http://dx.doi.org/10.1016/j.jalz.2014.05.323 . 10.1016/j.jalz.2014.05.323 . published Alzheimer's & Dementia

Antifungal and anti-inflammatory claims for wild carrot essential oil

Valente, J.; Resende, R.; Zuzarte, M.; Goncalves, M. J.; Lopes, M. C.; Cavaleiro, C.; Pereira, C.; Salgueiro, L.; Cruz, M. T., Planta Medica. 1454 - 1454. 16. 80. 2014. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000345550400318&KeyUID=WOS:000345550400318 . Planta Medica

Activation of the endoplasmic reticulum stress response by the amyloid-beta 1-40 peptide in brain endothelial cells

Fonseca, Ana Catarina R. G.; Ferreiro, Elisabete; Oliveira, Catarina R.; Cardoso, Sandra M.; Pereira, Claudia F., Biochimica Et Biophysica Acta-Molecular Basis of Disease. 2191 - 2203. 12. 1832. 2013. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000327567600030&KeyUID=WOS:000327567600030 . 10.1016/j.bbadis.2013.08.007 . Biochimica Et Biophysica Acta-Molecular Basis of Disease

Effect of a-Synuclein on amyloid ß-Induced toxicity: Relevance to lewy body variant of alzheimer disease

Resende, R.; Marques, S.C.F.; Ferreiro, E.; Simões, I.; Oliveira, C.R.; Pereira, C.M.F., Neurochemical Research. 797 - 806. 4. 38. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876164250&partnerID=MN8TOARS . 10.1007/s11064-013-0982-7 . Neurochemical Research

Inhibition of mitochondrial cytochrome c oxidase potentiates Aß-induced ER stress and cell death in cortical neurons

Costa, R.O.; Ferreiro, E.; Oliveira, C.R.; Pereira, C.M.F., Molecular and Cellular Neuroscience. 1 - 8. 52. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870349573&partnerID=MN8TOARS . 10.1016/j.mcn.2012.09.005 . Molecular and Cellular Neuroscience

Leptin and ghrelin prevent hippocampal dysfunction induced by Aß oligomers

Martins, I.; Gomes, S.; Costa, R.O.; Otvos, L.; Oliveira, C.R.; Resende, R.; Pereira, C.M.F., Neuroscience. 41 - 51. 241. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876430099&partnerID=MN8TOARS . 10.1016/j.neuroscience.2013.02.062 . Neuroscience

Endoplasmic reticulum stress occurs downstream of GluN2B subunit of N-methyl-d-aspartate receptor in mature hippocampal cultures treated with amyloid-ß oligomers

Costa, R.O.; Lacor, P.N.; Ferreira, I.L.; Resende, R.; Auberson, Y.P.; Klein, W.L.; Oliveira, C.R.; Rego, A.C.; Pereira, C.M.F., Aging Cell. 823 - 833. 5. 11. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866452758&partnerID=MN8TOARS . 10.1111/j.1474-9726.2012.00848.x . Aging Cell

Amyloid-Beta Peptide 1-42 Causes Microtubule Deregulation through N-methyl-D-aspartate Receptors in Mature Hippocampal Cultures

Mota, Sandra I.; Ferreira, Ildete L.; Pereira, Claudia; Oliveira, Catarina R.; Cristina Rego, A., Current Alzheimer Research. 844 - 856. 7. 9. 2012. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000308863600009&KeyUID=WOS:000308863600009 . Current Alzheimer Research

Amyloid-beta peptide 1-42 causes microtubule deregulation through N-methyl-D-aspartate receptors in mature hippocampal cultures

Mota, S.I.; Ferreira, I.L.; Pereira, C.; Oliveira, C.R.; Rego, A.C., Current Alzheimer Research. 844 - 856. 7. 9. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866468436&partnerID=MN8TOARS . 10.2174/156720512802455322 . Current Alzheimer Research

Endoplasmic reticulum stress: A new playER in tauopathies

Ferreiro, E.; Pereira, C.M.F., Journal of Pathology. 687 - 692. 5. 226. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857998807&partnerID=MN8TOARS . 10.1002/path.3977 . Journal of Pathology

Epigenetic regulation of BACE1 in Alzheimer's disease patients and in transgenic mice

Marques, S.C.F.; Lemos, R.; Ferreiro, E.; Martins, M.; de Mendonça, A.; Santana, I.; Outeiro, T.F.; Pereira, C.M.F., Neuroscience. 256 - 266. 220. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864770859&partnerID=MN8TOARS . 10.1016/j.neuroscience.2012.06.029 . Neuroscience

Amyloid ß-induced ER stress is enhanced under mitochondrial dysfunction conditions

Costa, R.O.; Ferreiro, E.; Martins, I.; Santana, I.; Cardoso, S.M.; Oliveira, C.R.; Pereira, C.M.F., Neurobiology of Aging. 4. 33. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856951448&partnerID=MN8TOARS . 10.1016/j.neurobiolaging.2011.04.011 . Neurobiology of Aging

Mitochondrial- and endoplasmic reticulum-associated oxidative stress in Alzheimer's disease: from pathogenesis to biomarkers.

Ferreiro E; Baldeiras I; Ferreira IL; Costa RO; Rego AC; Pereira CF; Oliveira CR, 2012. http://europepmc.org/abstract/med/22701485 . 10.1155/2012/735206 .

Injury markers in peripheral blood mononuclear cells from mild cognitive impairment and Alzheimer’s disease patients

Ferreira, Ildete Luisa; Mota, Sandra Isabel; Costa, Rui Miguel Oliveira da; Padovano, C; Fonseca, Ana Catarina Ribeiro da Graça; Letra, Liliana; Resende de Oliveira, Catarina; et al, Journal of Neurodegenerative Diseases. Supplement. 1. 2011. published Journal of Neurodegenerative Diseases

Amyloid-beta oligomers cause microtubule deregulation through NMDA receptors in mature hippocampal neurons

Mota, Sandra Isabel; Ferreira, Ildete Luisa; Resende de Oliveira, Catarina; Pereira, Cláudia; Rego, Ana Cristina Carvalho, Journal of Neurodegenerative Disorders. Supplement. 1. 2011. published Journal of Neurodegenerative Disorders

Epigenetics in neurodegeneration: A new layer of complexity

Marques, S.C.F.; Oliveira, C.R.; Pereira, C.M.F.; Outeiro, T.F., Progress in Neuro-Psychopharmacology and Biological Psychiatry. 348 - 355. 2. 35. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952900959&partnerID=MN8TOARS . 10.1016/j.pnpbp.2010.08.008 . Progress in Neuro-Psychopharmacology and Biological Psychiatry

Mitochondria control NMDA receptor-dependent calcium rise evoked by amyloid-ß 1-42 oligomers in rat cortical neurons

Ferreiro, Elisabete; Ferreira, Ildete Luisa; Cardoso, Joao M.; Pereira, Cláudia; Resende de Oliveira, Catarina; Rego, Ana Cristina Carvalho, Alzheimer's & Dementia: Journal of Alzheimer's Association. 4. 7. 2011. published Alzheimer's & Dementia: Journal of Alzheimer's Association

ROLE OF GLYCOGEN SYNTHASE KINASE-3B ON TAU PHOSPHORYLATION IN ALZHEIMER'S DISEASE

Resende, Rosa; Oliveira, Catarina Resende; Pereira, Claudia M. F., Advances in Medicine and Biology, Vol 2. 197 - 210. 2. 2010. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000278696200007&KeyUID=WOS:000278696200007 . Advances in Medicine and Biology, Vol 2

Cholesterol and statins in Alzheimer's disease: Current controversies

Fonseca, A.C.R.G.; Resende, R.; Oliveira, C.R.; Pereira, C.M.F., Experimental Neurology. 282 - 293. 2. 223. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952583554&partnerID=MN8TOARS . 10.1016/j.expneurol.2009.09.013 . Experimental Neurology

ER stress-mediated apoptotic pathway induced by aß peptide requires the presence of functional mitochondria

Costa, R.O.; Ferreiro, E.; Cardoso, S.M.; Oliveira, C.R.; Pereira, C.M.F., Journal of Alzheimer's Disease. 625 - 636. 2. 20. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954516455&partnerID=MN8TOARS . 10.3233/JAD-2010-091369 . Journal of Alzheimer's Disease

Alzheimer's disease: The quest to understand complexity

Marques, S.C.F.; Oliveira, C.R.; Outeiro, T.F.; Pereira, C.M.F., Journal of Alzheimer's Disease. 373 - 383. 2. 21. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957352488&partnerID=MN8TOARS . 10.3233/JAD-2010-100303 . Journal of Alzheimer's Disease

Epigenetics and Neurodegeneration: A Connection Overlooked

Marques, Sueli C. F.; Pereira, Claudia M. F.; Outeiro, Tiago F., Epigenetics: Mechanism, Functions and Human Effects. 241 - 252. 2010. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000278550400010&KeyUID=WOS:000278550400010 . Epigenetics: Mechanism, Functions and Human Effects

Multiple Defects in Energy Metabolism in Alzheimer's Disease

Ferreira, I. L.; Resende, R.; Ferreiro, E.; Rego, A. C.; Pereira, C. F., Current Drug Targets. 1193 - 1206. 10. 11. 2010. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000285183900002&KeyUID=WOS:000285183900002 . Current Drug Targets

Communication between endoplamic reticulum and mitochondria in the neuronal death induced by amyloid-beta peptide

Ferreiro, E.; Costa, R.; Resende, R.; Marques, S.; Cardoso, S.; Oliveira, C. R.; Pereira, C., Journal of the Neurological Sciences. 280 - 281. 1-2. 283. 2009. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000268609400202&KeyUID=WOS:000268609400202 . 10.1016/j.jns.2009.02.158 . Journal of the Neurological Sciences

Mitochondria as a therapeutic target in Alzheimer's disease and diabetes

Moreira, P.I.; Cardoso, S.M.; Pereira, C.M.; Santos, M.S.; Oliveira, C.R., CNS and Neurological Disorders - Drug Targets. 492 - 511. 6. 8. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-75849136180&partnerID=MN8TOARS . 10.2174/187152709789824651 . CNS and Neurological Disorders - Drug Targets

Neuroprotective effects of statins in an in vitro model of alzheimer's disease

Fonseca, A.C.R.G.; Proena, T.; Resende, R.; Oliveira, C.R.; Pereira, C.M.F., Journal of Alzheimer's Disease. 503 - 517. 3. 17. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-67849099662&partnerID=MN8TOARS . 10.3233/JAD-2009-1067 . Journal of Alzheimer's Disease

Statins prevent beta-amyloid-induced toxicity in cortical neurons

Pereira, Cláudia; Fonseca, Ana Catarina Ribeiro da Graça; Resende, Rosa; Ferreiro, Elisabete; Resende de Oliveira, Catarina; Pereira, C. M. F.; Fonseca, A. C.; et al, Journal of the Neurological Sciences. 281 - 281. 1. 283. 2009. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000268609400203&KeyUID=WOS:000268609400203 . 10.1016/j.jns.2009.02.159 . published Journal of the Neurological Sciences

ER-mediated stress induces mitochondrial-dependent caspases activation in NT2 neuron-like cells

Arduíno, D.M.; Raquel Esteves, A.; Filipa Domingues, A.; Pereira, C.M.F.; Cardoso, S.M.; Oliveira, C.R., BMB Reports. 719 - 724. 11. 42. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-73449102905&partnerID=MN8TOARS . BMB Reports

ER stress is involved in Aß-induced GSK-3ß activation and tau phosphorylation

Resende, R.; Ferreiro, E.; Pereira, C.; Oliveira, C.R., Journal of Neuroscience Research. 2091 - 2099. 9. 86. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-48249157930&partnerID=MN8TOARS . 10.1002/jnr.21648 . Journal of Neuroscience Research

The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway

Ferreiro, E.; Oliveira, C.R.; Pereira, C.M.F., Neurobiology of Disease. 331 - 342. 3. 30. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-43649083316&partnerID=MN8TOARS . 10.1016/j.nbd.2008.02.003 . Neurobiology of Disease

Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease

Resende, R.; Moreira, P.I.; Proença, T.; Deshpande, A.; Busciglio, J.; Pereira, C.; Oliveira, C.R., Free Radical Biology and Medicine. 2051 - 2057. 12. 44. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-43849096294&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2008.03.012 . Free Radical Biology and Medicine

Cross-talk between endoplasmic reticulum and mitochondria in the neurotoxicity induced by Alzheimer's disease–associated beta-amyloid peptide

Pereira, Cláudia; Ferreiro, Elisabete; Costa, Rui Miguel Oliveira da; Resende, Rosa; Morais Cardoso, Sandra; Resende de Oliveira, Catarina, Alzheimer’s and Dementia . T345 - T345. 4. 4. 2008. published Alzheimer’s and Dementia

Neurotoxic effect of oligomeric and fibrillar species of amyloid-beta peptide 1-42: Involvement of endoplasmic reticulum calcium release in oligomer-induced cell death

Resende, R.; Ferreiro, E.; Pereira, C.; Resende de Oliveira, C., Neuroscience. 725 - 737. 3. 155. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-49249118742&partnerID=MN8TOARS . 10.1016/j.neuroscience.2008.06.036 . Neuroscience

Involvement of mitochondria in endoplasmic reticulum stress-induced apoptotic cell death pathway triggered by the prion peptide PrP 106-126

Ferreiro, E.; Costa, R.; Marques, S.; Cardoso, S.M.; Oliveira, C.R.; Pereira, C.M.F., Journal of Neurochemistry. 766 - 776. 3. 104. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-38049162500&partnerID=MN8TOARS . 10.1111/j.1471-4159.2007.05048.x . Journal of Neurochemistry

Does mitochondria impairment affect endoplasmic reticulum function during amyloid-beta toxicity?

Costa, R.; Ferreiro, E.; Oliveira, C. R.; Pereira, C.; Costa, Rui Miguel Oliveira da; Ferreiro, Elisabete; Resende de Oliveira, Catarina; Pereira, Cláudia, Journal of Neurochemistry. 68 - 69. Supplement. 102. 2007. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000248991600162&KeyUID=WOS:000248991600162 . published Journal of Neurochemistry

Bcl-2 overexpression protects against amyloid-beta and prion toxicity in GT1-7 neural cells

Ferreiro, Elisabete; Eufrasio, Ana; Pereira, Claudia; Oliveira, Catarina R.; Rego, A. Cristina; Ferreiro, E.; Eufrásio, A.; et al, Journal of Alzheimers Disease. 223 - 228. 3. 12. 2007. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000252300000003&KeyUID=WOS:000252300000003 . Journal of Alzheimers Disease

Susceptibility of hippocampal neurons to Aß peptide toxicity is associated with perturbation of Ca2+ homeostasis

Resende, R.; Pereira, C.; Agostinho, P.; Vieira, A.P.; Malva, J.O.; Oliveira, C.R., Brain Research. 11 - 21. 1. 1143. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947303240&partnerID=MN8TOARS . 10.1016/j.brainres.2007.01.071 . Brain Research

Neurodegeneration in Alzheimer's disease: Inter-organelle cross-talk and oxidative stress in cell life and death decisions

Ferreiro, Elisabete; Resende, Rosa; Costa, Rui Miguel Oliveira da; Moreira, Paula Isabel; Morais Cardoso, Sandra; Pereira, Cláudia; Resende de Oliveira, Catarina; et al, Free Radical Research. S11 - S11. 41. 2007. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000252296300021&KeyUID=WOS:000252296300021 . Free Radical Research

An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and amyloid-beta peptides neurotoxicity

Ferreiro, E.; Resende, R.; Costa, R.; Oliveira, C.R.; Pereira, C.M.F., Neurobiology of Disease. 669 - 678. 3. 23. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33747195017&partnerID=MN8TOARS . 10.1016/j.nbd.2006.05.011 . Neurobiology of Disease

In vitro study of Amyloid-ß peptide toxicity. The role of physical state.

Resende, Rosa; Batista, M; Pereira, Cláudia; Resende de Oliveira, Catarina, Proceedings of the 10th International Conference on Alzheimer’s Disease and Related Disorders. 455 - 459. 2006. published Proceedings of the 10th International Conference on Alzheimer’s Disease and Related Disorders

Mechanism of amyloid-beta induced early synaptotoxicity.

Ferreiro, Elisabete; Resende, Rosa; Resende de Oliveira, Catarina; Pereira, Cláudia, Sinapse. 101 - 101. 1. 5 . 2005. published Sinapse

Endoplasmic reticulum dysfunction and oxidative stress induced by the prion peptide

Ferreiro, EB; Oliveira, CR; Pereira, CM, Journal of Neurochemistry. 174 - 175. 94. 2005. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000231673401076&KeyUID=WOS:000231673401076 . Journal of Neurochemistry

Alzheimer's disease-associated neurotoxic mechanisms and neuroprotective strategies

Pereira, C.; Agostinho, P.; Moreira, P.I.; Cardoso, S.M.; Oliveira, C.R., Current Drug Targets: CNS and Neurological Disorders. 383 - 403. 4. 4. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-23144463734&partnerID=MN8TOARS . 10.2174/1568007054546117 . Current Drug Targets: CNS and Neurological Disorders

The crosstalk between the endoplasmic reticulum and mitochondria in Alzheimer's disease

Cardoso, SM; Ferreiro, E; Oliveira, CR; Pereira, C, Febs Journal. 55 - 55. 272. 2005. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000234826100186&KeyUID=WOS:000234826100186 . Febs Journal

Aeroallergens sensitization in an allergic paediatric population of Cova da Beira, Portugal.

Loureiro, G; Rabaca, M A; Blanco, B; Andrade, S; Chieira, C; Pereira, C, Allergologia et immunopathologia. 192 - 8. 4. 33. 2005. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:16045856&KeyUID=MEDLINE:16045856 . 10.1157/13077742 . Allergologia et immunopathologia

Protective effect of zinc on amyloid-ß 25-35 and 1-40 mediated toxicity

Cardoso, S.M.; Rego, A.C.; Pereira, C.; Oliveira, C.R., Neurotoxicity Research. 273 - 281. 4. 7. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-27744456147&partnerID=MN8TOARS . 10.1007/BF03033885 . Neurotoxicity Research

Neurodegenerative pathways in Parkinson's disease: Therapeutic strategies

Cardoso, S.M.; Moreira, P.I.; Agostinho, P.; Pereira, C.; Oliveira, C.R., Current Drug Targets: CNS and Neurological Disorders. 405 - 419. 4. 4. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-23144431757&partnerID=MN8TOARS . 10.2174/1568007054546072 . Current Drug Targets: CNS and Neurological Disorders

Cell degeneration induced by amyloid-ß peptides: Implications for Alzheimer's disease

Pereira, C.; Ferreiro, E.; Cardoso, S.M.; De Oliveira, C.R.; Pereira, C; Ferreiro, E; Cardoso, SM; de Oliveira, CR, Journal of Molecular Neuroscience. 97 - 104. 1-2. 23. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-4344669435&partnerID=MN8TOARS . 10.1385/JMN:23:1-2:097 . Journal of Molecular Neuroscience

Involvement of endoplasmic reticulum Ca2+ release through ryanodine and inositol 1,4,5-triphosphate receptors in the neurotoxic effects induced by the amyloid-ß peptide

Ferreiro, E.; Oliveira, C.R.; Pereira, C.M.F., Journal of Neuroscience Research. 872 - 880. 6. 76. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-2642541799&partnerID=MN8TOARS . 10.1002/jnr.20135 . Journal of Neuroscience Research

[Neuroprotection strategies: effect of vinpocetine in vitro oxidative stress models].

Pereira, Claudia; Agostinho, Paula; Moreira, Paula I; Duarte, Ana I; Santos, Maria S; Oliveira, Catarina R, Acta medica portuguesa. 401 - 6. 6. 16. 2003. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:15631851&KeyUID=MEDLINE:15631851 . Acta medica portuguesa

Neuroprotection strategies: Effect of vinpocetinein in vitro oxidative stress models | Estratégias de neuroprotecção: Efeito da vimpocetina em modelos in vitro de stresse oxidativo

Pereira, C.; Agostinho, P.; Moreira, P.I.; Duarte, A.I.; Santos, M.S.; Oliveira, C.R., Acta Medica Portuguesa. 401 - 406. 6. 16. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-9644310235&partnerID=MN8TOARS . Acta Medica Portuguesa

Effect of Zinc Ions on the Cytotoxicity Induced by the Amyloid beta-Peptide

Moreira, Paula; Pereira, Claudia; Santos, Maria S.; Oliveira, Catarina, Antioxidants & Redox Signaling. 317 - 325. 2. 2. 2000. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000207500700014&KeyUID=WOS:000207500700014 . 10.1089/ars.2000.2.2-317 . Antioxidants & Redox Signaling

Vinpocetine attenuates the metabolic dysfunction induced by amyloid beta-peptides in PC12 cells

Pereira, C; Agostinho, P; Oliveira, CR; Pereira, C.; Agostinho, P.; Oliveira, C.R., Free Radical Research. 497 - 506. 5. 33. 2000. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000166441800006&KeyUID=WOS:000166441800006 . 10.1080/10715760000301041 . Free Radical Research

Susceptibility to ß-amyloid-induced toxicity is decreased in Goto- Kakizaki diabetic rats: Involvement of oxidative stress

Pereira, C.; Moreira, P.; Seiça, R.; Santos, M.S.; Oliveira, C.R., Experimental Neurology. 383 - 391. 1. 161. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034051172&partnerID=MN8TOARS . 10.1006/exnr.1999.7270 . Experimental Neurology

Effect of zinc ions on the cytotoxicity induced by the amyloid ß- peptide

Moreira, P.; Pereira, C.; Santos, M.S.; Oliveira, C., Antioxidants and Redox Signaling. 317 - 325. 2. 2. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033949740&partnerID=MN8TOARS . Antioxidants and Redox Signaling

Oxidative glutamate toxicity involves mitochondrial dysfunction and perturbation of intracellular Ca2+ homeostasis

Pereira, CF; de Oliveira, CR, Neuroscience Research. 227 - 236. 3. 37. 2000. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000088427400008&KeyUID=WOS:000088427400008 . 10.1016/S0168-0102(00)00124-3 . Neuroscience Research

Mitochondrial function is differentially affected upon oxidative stress

Cardoso, S.M.; Pereira, C.; Oliveira, C.R., Free Radical Biology and Medicine. 3 - 13. 1-2. 26. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0345222531&partnerID=MN8TOARS . 10.1016/S0891-5849(98)00205-6 . Free Radical Biology and Medicine

Involvement of oxidative stress on the impairment of energy metabolism induced by Aß peptides on PC12 cells: Protection by antioxidants

Pereira, C.; Santos, M.S.; Oliveira, C., Neurobiology of Disease. 209 - 219. 3. 6. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033022771&partnerID=MN8TOARS . 10.1006/nbdi.1999.0241 . Neurobiology of Disease

Metabolic inhibition increases glutamate susceptibility on a PC12 cell line

Pereira, C; Santos, MS; Oliveira, C; Pereira, C.; Santos, M.S.; Oliveira, C., Journal of Neuroscience Research. 360 - 370. 3. 51. 1998. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000071805700009&KeyUID=WOS:000071805700009 . 10.1002/(SICI)1097-4547(19980201)51:3<360::AID-JNR9>3.3.CO;2-7 . Journal of Neuroscience Research

Mitochondrial function impairment induced by amyloid beta-peptide on PC12 cells

Pereira, C; Santos, MS; Oliveira, C; Pereira, C.; Santos, M.S.; Oliveira, C., Neuroreport. 1749 - 1755. 8. 9. 1998. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000074198700015&KeyUID=WOS:000074198700015 . 10.1097/00001756-199806010-00015 . Neuroreport

The protective effect of vitamin E, idebenone and reduced glutathione on free radical mediated injury in rat brain synaptosomes

Cardoso, S.M.; Pereira, C.; Oliveira, C.R., Biochemical and Biophysical Research Communications. 703 - 710. 3. 246. 1998. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032577242&partnerID=MN8TOARS . 10.1006/bbrc.1998.8563 . Biochemical and Biophysical Research Communications

Glutamate toxicity on a PC12 cell line involves glutathione (GSH) depletion and oxidative stress

Pereira, C.M.F.; Oliveira, C.R., Free Radical Biology and Medicine. 637 - 647. 4. 23. 1997. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030757990&partnerID=MN8TOARS . 10.1016/S0891-5849(97)00020-8 . Free Radical Biology and Medicine

Contribution of plasma membrane and endoplasmic reticulum Ca2+-ATPases to the synaptosomal [Ca2+]i increase during oxidative stress

Pereira, C.; Ferreira, C.; Carvalho, C.; Oliveira, C., Brain Research. 269 - 277. 1-2. 713. 1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029928472&partnerID=MN8TOARS . 10.1016/0006-8993(95)01554-X . Brain Research

Effect of lipid peroxidation on [Ca2+]i of rat synaptosomes

Pereira, Cláudia; Resende de Oliveira, Catarina, Journal of Neurochemistry. S151D - S151D. supplement. 1993. published Journal of Neurochemistry

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Information of exclusive responsibility of the researcher 19-05-2024 , from platform CIÊNCIAVITAE.

2023/05/01 - 2024/04/30

Deciphering the key events of micro- and nanoplastics toxicity triggered in skin to establish the adverse outcome pathway (AOP)

Sem código

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Laboratoires Vichy

2023/05/01 - 2027/04/30

De-risking metabolic, environmental and behavioral determinants of obesity in children, adolescents and young adults (PAS GRAS)

na

Researcher

Universidade de Coimbra

Funders: Horizon 2020

2021/07/08 - 2022/12/31

ValSar: Valorização do Sargaço da Costa Litoral Norte

MAR-04.03.01-FEAMP-0502 MAR2020

Researcher

Universidade de Coimbra

2021/09 - 2022/03/31

Doença Bipolar - Um outro lado

#385-PCC2021

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

2020/01 - 2026/12

MIA-Portugal

857524

Researcher

Universidade de Coimbra

Funders: Horizon 2020

2020/02/01 - 2024

Lipidomic fingerprint of MAMs in Alzheimer's disease - impact of its modulation on neuronal metabolism

SFRH/BD/148801/2019

Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra; Universidade de Aveiro Centro de Estudos do Ambiente e do Mar

Funders: Fundação para a Ciência e a Tecnologia

2019 - 2021

Saude no Saber

45-2019/478

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Ciência Viva

2019 - 2022

Impact of the action of natural products on human innate immune and tumor cells

88887.194785/2018-00

Researcher

Universidade Estadual Paulista Júlio de Mesquita Filho - Câmpus de Botucatu

Funders: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

2018/07/26 - 2022/07/25

The ups and downs of cellular stress. the "MAM" hypothesis for Bipolar disorder pathophysiology

CENTRO-01-0145-FEDER-028214

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2018 - 2021

Skin allergens: molecules with an improbable therapeutic application for Alzheimer’s disease

CENTRO-01-0145-FEDER-029369

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2018/07/26 - 2022/07/25

Os altos e baixos do stresse celular: a "hipótese MAM" para a patofisiologia da doença Bipolar

PTDC/MED-NEU/28214/2017

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2018 - 2021

InPaCTus

COMPETE 21874

Principal investigator

Universidade de Coimbra

Funders: Agência Nacional de Inovação SA

2017/01/01 - 2020/12/31

HealthyAging2020

CENTRO-01-0145-FEDER-000012

Researcher

Universidade de Coimbra

Funders: EU Framework Programme for Research and Innovation Excellent Science

2017 - 2018

New BACE1 inhibitors for the treatment of Alzheimer's disease: an approach for the development of effective and safe substrate-selective inhibitors

EDGAR CRUZ SILVA 2017

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação Edgar Cruz e Silva

2017 - 2018

Valorization of the thermal resorts of the Centre Region- characterization of the bioactive potential of the thermal water resources of the region: study of the therapeutic potential of thermal waters- dermocosmetic

CENTRO-04-3928-FEDER-000010

Researcher

Universidade de Coimbra

Funders: Horizon 2020 Framework Programme

2016/04/01 - 2019/06/30

Drugs2CAD

CENTRO-01-0247- FEDER-003269

Researcher

Universidade de Coimbra

Funders: European Regional Development Fund

2014 - 2015

Diagnóstico y combate molecular de tres enfermedades neurodegenerativas (Parkinson, fenilcetonuria y amiloidosis TTR)

NEUROMED

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: European Commission Seventh Framework Programme for Research and Technological Development

2014/03/01 - 2015/09/30

Ageing@Coimbra: A Co-location Centre in the European Knowledge and Innovation Network for Active and Healthy Ageing

info:eu-repo/grantAgreement/FCT/3599-PPCDTI/135805/PT

Funders: Universidade do Algarve Faculdade de Ciências e Tecnologia

2013 - 2014

How does autophagy modulate inflammasome activation?

GAI 2014_2

Principal investigator

Universidade de Coimbra Faculdade de Medicina

Funders: Universidade de Coimbra Faculdade de Medicina

2013 - 2014

Faulty cross-talk between endothelial cells and neurons in Alzheimer´s disease brain. Does endoplasmic reticulum stress play a role?

GAI 2014

Researcher

Universidade de Coimbra Faculdade de Medicina

Funders: Universidade de Coimbra Faculdade de Medicina

2013/06/15 - 2015/11/30

Tratamento da doença de Alzheimer com um novo peptídeo inibidor da BACE1

PTDC/NEU-SCC/1351/2012

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2012 - 2013

Influence of cell age and CX3CL1/CX3CR1 signaling on microglial-neuronal dialogue in Alzheimer’s disease pathogenesis

EDGAR CRUZ SILVA 2012

Researcher

Universidade de Lisboa Faculdade de Farmácia

Funders: Fundação Edgar Cruz e Silva

2011/01/01 - 2012/12/31

Strategic Project - LA 1 - 2011-2012

PEst-C/SAU/LA0001/2011

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2011 - 2012

Amyloid-beta-sensitized dendritic cells as Alzheimer's disease vaccine

01CP11

Principal investigator

Universidade de Coimbra Faculdade de Medicina

Funders: Universidade de Coimbra Faculdade de Medicina

2011 - 2012

Crosstalk between endoplasmic reticulum and mitochondria in diabetes-related neurodegeneration: bringing bedside problems to the bench

02CP11

Principal investigator

Universidade de Coimbra Faculdade de Medicina

Funders: Universidade de Coimbra Faculdade de Medicina

2010/01/01 - 2013/06/30

Derivados de Benzazolo Marcados com Fluor-18 e Tecnécio-99m para Visualização In Vivo de Depósitos de Amilóide

PTDC/QUI-QUI/102049/2008

Universidade de Coimbra Centro de Neurociências e Biologia Celular; Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes; Universidade de Lisboa Instituto Superior Técnico; Universidade de Coimbra

Funders: Fundação para a Ciência e a Tecnologia

2010 - 2012

The pathological interaction between diabetes and Alzheimer’s disease: exploring the role of brain endothelial mitochondria and uncoupling proteins

PTDC/SAU-NEU/103325/2008

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2010/06/01 - 2013/06/30

Perfis dinâmicos do óxido nítrico no cérebro: regulação da respiração celular com implicações para a doença de Alzheimer e para o envelhecimento

PTDC/SAU-NEU/103538/2008

Universidade de Coimbra; Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2009 - 2011

Phosphorylation and oxidation of NMDA receptor subunits in Alzheimer’s disease and protective role of memantine

LUNDBECK2009

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Lundbeck Portugal

2008 - 2010

Contribution of N-methyl-D-aspartate receptor subunits to neuronal dysfunction in Alzheimer’s disease

PTDC/SAU-NEU/71675/2006

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2008 - 2010

Towards novel inhibitors of Alzheimer's disease-associated beta-amyloid aggregation and toxicity: from statins as potential leads to the design of effective drugs

III/40/2008

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Universidade de Coimbra Instituto de Investigação Interdisciplinar

2008 - 2010

Early Diagnosis of Alzheimer’s Disease: evaluation of recent classification criteria and proposal of new diagnostic tools

PIC/IC/83206/2007

Researcher

Hospitais da Universidade de Coimbra; Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2007 - 2013

Aging, stress and chronic diseases: from mechanisms to therapeutics

CENTRO-07-ST24-FEDER-002006

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: EU Framework Programme for Research and Innovation Excellent Science

2007 - 2007

Let’s study the brain: neuroscientists at school and schools at neuroscience laboratories

BAW2007

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

2007 - 2013

New strategies to manage brain diseases

CENTRO-07-ST24-FEDER-002002

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: EU Framework Programme for Research and Innovation Excellent Science

2005 - 2007

Signaling pathways involved in the cross-talk between alpha-synuclein and beta-amyloid proteins in Alzheimer’s disease neurodegeneration

III_CP2005

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Universidade de Coimbra Instituto de Investigação Interdisciplinar

2004 - 2005

Cross-talk” between mitochondria and endoplasmic reticulum in Alzheimer’s disease. Studies with cybrids

FOE WOMEN IN SCIENCE 2004

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

1999 - 2003

A comparative study of the neurotoxic mechanisms of prion and amyloid-beta peptides. Potential neuroprotective strategies

POCTI/1999/NSE/36101

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

1995 - 1998

Mecanismos de degenerescência celular em dois modelos de stress oxidativo induzido por glutamato e pela proteína beta-amilóide. Implicações para a etiopatogenia da doença de Alzheimer

BD/3889/94

PhD Student Fellow

Universidade de Coimbra Faculdade de Ciencias e Tecnologia

Funders: Fundação para a Ciência e a Tecnologia

1992 - 1993

Efeito da peroxidação lipídica na actividade respiratória mitocondrial e nos mecanismos de regulação do cálcio em sinaptossomas

BM/1444/91-ID

Master Student Fellow

Universidade de Coimbra Faculdade de Ciencias e Tecnologia

Funders: Fundação para a Ciência e a Tecnologia

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