Filipe Valente Duarte

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Researcher

Overview

Regulation of mitochondrial fission by brain-derived neurotrophic factor (BDNF): role in synaptic plasticity and in epileptogenesis. PTDC/MED-NEU/3736/2020 (Role: Co-PI)

Publications

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Information about journal articles, updated at 05-12-2021, from platform CIÊNCIAVITAE.

Immunomodulatory Properties of Umbilical Cord Blood-Derived Small Extracellular Vesicles and Their Therapeutic Potential for Inflammatory Skin Disorders

Sílvia C. Rodrigues; Renato M. S. Cardoso; Patricia C. Freire; Cláudia F. Gomes; Filipe V. Duarte; Ricardo Pires das Neves; Joana Simões-Correia, International Journal of Molecular Sciences. 2021. https://doi.org/10.3390/ijms22189797 . 10.3390/ijms22189797 . International Journal of Molecular Sciences

Toxicological Profile of Umbilical Cord Blood-Derived Small Extracellular Vesicles

Silvia C. Rodrigues; Renato M. S. Cardoso; Claudia F. Gomes; Filipe V. Duarte; Patricia C. Freire; Ricardo Neves; Joana Simoes-Correia, Membranes. 2021. https://doi.org/10.3390/membranes11090647 . 10.3390/membranes11090647 . Membranes

Transient incubation of cultured hippocampal neurons in the absence of magnesium induces rhythmic and synchronized epileptiform-like activity

Mele, Miranda; Vieira, Ricardo; Correia, Bárbara; De Luca, Pasqualino; Duarte, Filipe V.; Pinheiro, Paulo S.; Duarte, Carlos B., Scientific Reports. 1. 11. 2021. http://dx.doi.org/10.1038/s41598-021-90486-y . 10.1038/s41598-021-90486-y . Scientific Reports

Development of an optimized and scalable method for isolation of umbilical cord blood-derived small extracellular vesicles for future clinical use

Cardoso, Renato M. S.; Rodrigues, Silvia C.; Gomes, Claudia F.; Duarte, Filipe V.; Romao, Maryse; Leal, Ermelindo C.; Freire, Patricia C.; Neves, Ricardo; Simões-Correia, Joana, Stem Cells Translational Medicine. 910 - 921. 6. 10. 2021. http://dx.doi.org/10.1002/sctm.20-0376 . 10.1002/sctm.20-0376 . published Stem Cells Translational Medicine

Mitochondrial microRNAs: A Putative Role in Tissue Regeneration

Rodrigues, Sílvia C.; Cardoso, Renato M. S.; Duarte, Filipe V., Biology. 12. 9. 2020. http://dx.doi.org/10.3390/biology9120486 . 10.3390/biology9120486 . published Biology

Mitochondrial physiology

Duarte, FV, Bioenergetics Communications. 2020. http://dx.doi.org/10.26124/bec:2020-0001.v1 . 10.26124bec2020-0001.v1 . Bioenergetics Communications

Enhanced ATP release and CD73-mediated adenosine formation sustain adenosine A 2A receptor over-activation in a rat model of Parkinson's disease

Marta Carmo; Francisco Q. Gonçalves; Paula M. Canas; Jean-Pierre Oses; Francisco D. Fernandes; Filipe V. Duarte; Carlos M. Palmeira; et al, British Journal of Pharmacology. 2019. https://doi.org/10.1111/bph.14771 . 10.1111/bph.14771 . British Journal of Pharmacology

Indirubin and NAD+ prevent mitochondrial ischaemia/reperfusion damage in fatty livers.

Teodoro JS; Varela AT; Duarte FV; Gomes AP; Palmeira CM; Rolo AP, European journal of clinical investigation. 2018. http://europepmc.org/abstract/med/29603199 . 10.1111/eci.12932 . European journal of clinical investigation

Mitochondrial damage and apoptosis: Key features in BDE-153-induced hepatotoxicity

Lilian Cristina Pereira; Luiz Felipe Cabral Miranda; Mariana Furio Franco-Bernardes; Maria Julia Tasso; Filipe Valente Duarte; Ana Teresa Inácio Varela; Anabela Pinto Rolo; Carlos Manuel Marques Palmeira; Daniel Junqueira Dorta, Chemico-Biological Interactions. 192 - 201. 291. 2018. https://doi.org/10.1016/j.cbi.2018.06.021 . 10.1016/j.cbi.2018.06.021 . Chemico-Biological Interactions

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

Théry, Clotilde; Witwer, Kenneth W; Aikawa, Elena; Alcaraz, Maria Jose; Anderson, Johnathon D; Andriantsitohaina, Ramaroson; Antoniou, Anna; et al, Journal of Extracellular Vesicles. 1. 7. 2018. http://dx.doi.org/10.1080/20013078.2018.1535750 . 10.1080/20013078.2018.1535750 . Journal of Extracellular Vesicles

Exposure to BDE-153 induces autophagy in HepG2 cells.

Pereira LC; Duarte FV; Varela ATIF; Rolo AP; Palmeira CMM; Dorta DJ, Toxicology in vitro : an international journal published in association with BIBRA. 2017. http://europepmc.org/abstract/med/28396260 . 10.1016/j.tiv.2017.04.005 . Toxicology in vitro : an international journal published in association with BIBRA

Adenosine receptors: regulatory players in the preservation of mitochondrial function induced by ischemic preconditioning of rat liver.

Duarte FV; Amorim JA; Varela AT; Teodoro JS; Gomes AP; Cunha RA; Palmeira CM; Rolo AP, Purinergic signalling. 2017. http://europepmc.org/abstract/med/27848069 . 10.1007/s11302-016-9548-x . Purinergic signalling

An autophagic process is activated in HepG2 cells to mediate BDE-100-induced toxicity

Lilian Cristina Pereira; Filipe Valente Duarte; Ana Teresa Inácio Ferreira Varela; Anabela Pinto Rolo; Carlos Manuel Marques Palmeira; Daniel Junqueira Dorta, Toxicology. 59 - 65. 376. 2017. https://doi.org/10.1016/j.tox.2016.05.022 . 10.1016/j.tox.2016.05.022 . Toxicology

Exposure to decabromodiphenyl ether (BDE-209) produces mitochondrial dysfunction in rat liver and cell death

Pereira, L.C.; Souza, A.O.; Tasso, M.J.; Oliveira, A.M.C.; Duarte, F.V.; Palmeira, C.M.; Dorta, D.J., Journal of Toxicology and Environmental Health - Part A: Current Issues. 1129 - 1144. 19-21. 80. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85033371791&partnerID=MN8TOARS . 10.1080/15287394.2017.1357370 . Journal of Toxicology and Environmental Health - Part A: Current Issues

Evaluation of Polybrominated Diphenyl Ether Toxicity on HepG2 Cells - Hexabrominated Congener (BDE-154) Is Less Toxic than Tetrabrominated Congener (BDE-47).

Souza AO; Tasso MJ; Oliveira AM; Pereira LC; Duarte FV; Oliveira DP; Palmeira CM; Dorta DJ, Basic & clinical pharmacology & toxicology. 2016. http://europepmc.org/abstract/med/27060917 . 10.1111/bcpt.12598 . Basic & clinical pharmacology & toxicology

Hepatic and skeletal muscle mitochondrial toxicity of chitosan oligosaccharides of normal and diabetic rats.

Teodoro JS; Gomes AP; Varela AT; Duarte FV; Rolo AP; Palmeira CM, Toxicology mechanisms and methods. 2016. http://europepmc.org/abstract/med/27790925 . 10.1080/15376516.2016.1222643 . Toxicology mechanisms and methods

Low-dose, subchronic exposure to silver nanoparticles causes mitochondrial alterations in Sprague-Dawley rats.

Teodoro JS; Silva R; Varela AT; Duarte FV; Rolo AP; Hussain S; Palmeira CM, Nanomedicine (London, England). 2016. http://europepmc.org/abstract/med/27171910 . 10.2217/nnm-2016-0049 . Nanomedicine (London, England)

Regulation of Mitochondrial Function and its Impact in Metabolic Stress

Duarte, F.V.; Amorim, J.A.; Palmeira, C.M.; Rolo, A.P., Current Medicinal Chemistry. 2468 - 2479. 20. 22. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84938567587&partnerID=MN8TOARS . 10.2174/0929867322666150514095910 . Current Medicinal Chemistry

The role of microRNAs in mitochondria: Small players acting wide

Duarte, F.V.; Palmeira, C.M.; Rolo, A.P., Genes. 865 - 886. 4. 5. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84907528499&partnerID=MN8TOARS . 10.3390/genes5040865 . Genes

Enhancement of brown fat thermogenesis using chenodeoxycholic acid in mice

Teodoro, J.S.; Zouhar, P.; Flachs, P.; Bardova, K.; Janovska, P.; Gomes, A.P.; Duarte, F.V.; et al, International Journal of Obesity. 1027 - 1034. 8. 38. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84905663740&partnerID=MN8TOARS . 10.1038/ijo.2013.230 . International Journal of Obesity

Dibenzofuran-induced mitochondrial dysfunction: Interaction with ANT carrier

Duarte, F.V.; Gomes, A.P.; Teodoro, J.S.; Varela, A.T.; Moreno, A.J.M.; Rolo, A.P.; Palmeira, C.M., Toxicology in Vitro. 2160 - 2168. 8. 27. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885795993&partnerID=MN8TOARS . 10.1016/j.tiv.2013.08.009 . Toxicology in Vitro

Berberine reverts hepatic mitochondrial dysfunction in high-fat fed rats: A possible role for SirT3 activation

Teodoro, J.S.; Duarte, F.V.; Gomes, A.P.; Varela, A.T.; Peixoto, F.M.; Rolo, A.P.; Palmeira, C.M., Mitochondrion. 637 - 646. 6. 13. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884937949&partnerID=MN8TOARS . 10.1016/j.mito.2013.09.002 . Mitochondrion

Uncovering the beginning of diabetes: The cellular redox status and oxidative stress as starting players in hyperglycemic damage

Teodoro, J.S.; Gomes, A.P.; Varela, A.T.; Duarte, F.V.; Rolo, A.P.; Palmeira, C.M., Molecular and Cellular Biochemistry. 103 - 110. 1-2. 376. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874278002&partnerID=MN8TOARS . 10.1007/s11010-012-1555-9 . Molecular and Cellular Biochemistry

Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis

Gomes, A.P.; Duarte, F.V.; Nunes, P.; Hubbard, B.P.; Teodoro, J.S.; Varela, A.T.; Jones, J.G.; et al, Biochimica et Biophysica Acta - Molecular Basis of Disease. 185 - 195. 2. 1822. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-83255163155&partnerID=MN8TOARS . 10.1016/j.bbadis.2011.10.008 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Exposure to dibenzofuran triggers autophagy in lung cells

Duarte, F.V.; Teodoro, J.S.; Rolo, A.P.; Palmeira, C.M., Toxicology Letters. 35 - 42. 1. 209. 2012. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000300268700005&KeyUID=WOS:000300268700005 . 10.1016/j.toxlet.2011.11.029 . Toxicology Letters

SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function

Price, N.L.; Gomes, A.P.; Ling, A.J.Y.; Duarte, F.V.; Martin-Montalvo, A.; North, B.J.; Agarwal, B.; et al, Cell Metabolism. 675 - 690. 5. 15. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860477354&partnerID=MN8TOARS . 10.1016/j.cmet.2012.04.003 . Cell Metabolism

Exposure to dibenzofuran affects lung mitochondrial function in vitro

Duarte, F.V.; Simões, A.M.; Teodoro, J.S.; Rolo, A.P.; Palmeira, C.M., Toxicology Mechanisms and Methods. 571 - 576. 8. 21. 2011. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000295177300002&KeyUID=WOS:000295177300002 . 10.3109/15376516.2011.576714 . Toxicology Mechanisms and Methods

Assessment of the toxicity of silver nanoparticles in vitro: A mitochondrial perspective

Teodoro, J.S.; Simões, A.M.; Duarte, F.V.; Rolo, A.P.; Murdoch, R.C.; Hussain, S.M.; Palmeira, C.M., Toxicology in Vitro. 664 - 670. 3. 25. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952039156&partnerID=MN8TOARS . 10.1016/j.tiv.2011.01.004 . Toxicology in Vitro

Indirubin-3'-oxime prevents hepatic I/R damage by inhibiting GSK-3ß and mitochondrial permeability transition

Varela, A.T.; Simões, A.M.; Teodoro, J.S.; Duarte, F.V.; Gomes, A.P.; Palmeira, C.M.; Rolo, A.P., Mitochondrion. 456 - 463. 5. 10. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955424602&partnerID=MN8TOARS . 10.1016/j.mito.2010.04.006 . Mitochondrion

Exposure to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin and tetraethyl lead affects lung mitochondria bioenergetics

Simes, A.M.; Duarte, F.V.; Teodoro, J.S.; Rolo, A.P.; Palmeira, C.M., Toxicology Mechanisms and Methods. 1 - 6. 1. 20. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77149123078&partnerID=MN8TOARS . 10.3109/15376510903527916 . Toxicology Mechanisms and Methods

Differential alterations in mitochondrial function induced by a choline-deficient diet: Understanding fatty liver disease progression

Teodoro, J.S.; Rolo, A.P.; Duarte, F.V.; Simões, A.M.; Palmeira, C.M., Mitochondrion. 367 - 376. 5-6. 8. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-54949089576&partnerID=MN8TOARS . 10.1016/j.mito.2008.07.008 . Mitochondrion

Indirubin-3'-oxime impairs mitochondrial oxidative phosphorylation and prevents mitochondrial permeability transition induction

Varela, A.T.; Gomes, A.P.; Simões, A.M.; Teodoro, J.S.; Duarte, F.V.; Rolo, A.P.; Palmeira, C.M., Toxicology and Applied Pharmacology. 179 - 185. 2. 233. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-56049123388&partnerID=MN8TOARS . 10.1016/j.taap.2008.08.005 . Toxicology and Applied Pharmacology

All projects

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Information of exclusive responsibility of the researcher 05-12-2021 , from platform CIÊNCIAVITAE.

2021/03 -

Regulation of mitochondrial fission by brain-derived neurotrophic factor (BDNF): role in synaptic plasticity and in epileptogenesis (co-PI)

PTDC / MED-NEU / 3736 / 2020

Principal investigator

CNC - Center for Neuroscience and Cell Biology, University of Coimbra

Funders: Fundação para a Ciência e a Tecnologia

2018/10 - 2021/05

Targeting the K+-Cl- cotransporter (KCC2) to maintain GABAergic neurotransmission: a novel therapeutic strategy for epilepsy

PTDC / MED-FAR / 30659 / 2017

Researcher

CNC - Center for Neuroscience and Cell Biology, University of Coimbra

Funders: Fundação para a Ciência e a Tecnologia

2014/09 - 2016/05

The role of miRNAs in the mitochondrial regulation in metabolic disease

SFRH/BPD/94898/2013

Post-doc Fellow

CNC - Center for Neuroscience and Cell Biology, University of Coimbra

Funders: Fundação para a Ciência e a Tecnologia

2013 - 2013

Chronic effects of silver nanoparticles (AgNPs) on rat liver, kidney and heart mitochondrial function

EOARD, ref. FA8655-13-1-3036

Integration into Research Grant Fellow

Department of Life Sciences, University of Coimbra

Funders: European Office of Aerospace Research and Development (USA)

2013/09 - 2016/05

Evaluation of the ability of PBDEs exposure to induce autophagy/mitophagy and cause mitochondrial biogenesis alterations in HepG2 cells

A018_2013

Invited Scientist Fellow

CNC - Center for Neuroscience and Cell Biology, University of Coimbra

Funders: National Research Center (CNPq - Brazil)

2011/12 - 2012/12

Ability of a mitochondria improver, Berberine, to attenuate Parkinson's Disease

RRIA 2011

Integration into Research Grant Fellow

CNC - Center for Neuroscience and Cell Biology, University of Coimbra

Funders: The Michael J. Fox foundation for Parkinson’s Research

2010/03 - 2013/03

Long-term beneficial influence of early metabolic control: prevention of hyperglycemic memory through stimulation of bioenergetics

Provided by PTCRIS: 103514

Integration into Research Grant Fellow

CNC - Center for Neuroscience and Cell Biology, University of Coimbra

Funders: Fundação para a Ciência e a Tecnologia

2008/01 - 2010/01

Modulation of the metabolic pathways regarding mitochondrial oxidative stress in hyperglycemic conditions - Relevance for diabetes prevention

PTDC / QUI / 72826 / 2006

Integration into Research Grant Fellow

CNC - Center for Neuroscience and Cell Biology, University of Coimbra

Funders: Fundação para a Ciência e a Tecnologia

2007/09 - 2012/11

Dibenzofuran exposure: cellular and mitochondrial damage

n/a

PhD Student Fellow

CNC - Center for Neuroscience and Cell Biology, University of Coimbra

Funders: Fundação para a Ciência e a Tecnologia

2007/09 - 2010/08

Alterations in the physiological pathways and molecular mechanisms regulating energy homeostasis in obesity and metabolic syndrome - Identification of new strategies and therapeutical targets

PTDC / SAU-OSM / 72443 / 2006

Integration into Research Grant Fellow

CNC - Center for Neuroscience and Cell Biology, University of Coimbra

Funders: Fundação para a Ciência e a Tecnologia

2007/06 - 2008/06

In vitro assessment of silver nanoparticles toxicity in hepatic mitochondrial function

EOARD, ref. FA8655- 07-1-3047

Integration into Research Grant Fellow

Department of Life Sciences, University of Coimbra

Funders: European Office of Aerospace Research and Development (USA)

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