Publications

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Information about journal articles, updated at 21-11-2021, from platform CIÊNCIAVITAE.

Biochemical diversity of cardoon flowers (Cynara cardunculus L.): Predicting PDO Mediterranean cheese textures

Barracosa, P.; Simões, I.; Martins, A.P.; Barros, M.; Pires, E., Food Bioscience. 39. 2021. http://dx.doi.org/10.1016/j.fbio.2020.100805 . 10.1016/j.fbio.2020.100805 . published Food Bioscience

Macrophages Infected by a Pathogen and a Non-pathogen Spotted Fever Group Rickettsia Reveal Differential Reprogramming Signatures Early in Infection

Curto, Pedro; Riley, Sean P.; Simões, Isaura; Martinez, Juan J., Frontiers in Cellular and Infection Microbiology. 9. 2019. http://dx.doi.org/10.3389/fcimb.2019.00097 . 10.3389/fcimb.2019.00097 . Frontiers in Cellular and Infection Microbiology

A Pathogen and a Non-pathogen Spotted Fever Group Rickettsia Trigger Differential Proteome Signatures in Macrophages

Curto, Pedro; Santa, Cátia; Allen, Paige; Manadas, Bruno; Simões, Isaura; Martinez, Juan J., Frontiers in Cellular and Infection Microbiology. 9. 2019. http://dx.doi.org/10.3389/fcimb.2019.00043 . 10.3389/fcimb.2019.00043 . Frontiers in Cellular and Infection Microbiology

An atypical aspartic protease modulates lateral root development in Arabidopsis thaliana

Soares, André; Niedermaier, Stefan; Faro, Rosário; Loos, Andreas; Manadas, Bruno; Faro, Carlos; Huesgen, Pitter F; Cheung, Alice Y; Simões, Isaura, Journal of Experimental Botany. 2157 - 2171. 7. 70. 2019. http://dx.doi.org/10.1093/jxb/erz059 . 10.1093/jxb/erz059 . Journal of Experimental Botany

Atypical and nucellin-like aspartic proteases: emerging players in plant developmental processes and stress responses

André Soares; Sofia M Ribeiro Carlton; Isaura Simões, Journal of Experimental Botany. 2019. https://doi.org/10.1093/jxb/erz034 . 10.1093/jxb/erz034 . Journal of Experimental Botany

Use of recombinant proteins as a simple and robust normalization method for untargeted proteomics screening: exhaustive performance assessment

Anjo, Sandra Isabel; Simões, Isaura; Castanheira, Pedro; Grãos, Mário; Manadas, Bruno, Talanta. 205. 2019. http://dx.doi.org/10.1016/j.talanta.2019.120163 . 10.1016/j.talanta.2019.120163 . Talanta

Cardoon-based rennets for cheese production

Almeida, Carla Malaquias; Simões, Isaura, Applied Microbiology and Biotechnology. 4675 - 4686. 11. 102. 2018. http://dx.doi.org/10.1007/s00253-018-9032-3 . 10.1007/s00253-018-9032-3 . Applied Microbiology and Biotechnology

Functional and structural characterization of synthetic cardosin B-derived rennet

Almeida, Carla Malaquias; Manso, José A.; Figueiredo, Ana C.; Antunes, Liliana; Cruz, Rui; Manadas, Bruno; Bur, Daniel; et al, Applied Microbiology and Biotechnology. 6951 - 6968. 18. 101. 2017. http://dx.doi.org/10.1007/s00253-017-8445-8 . 10.1007/s00253-017-8445-8 . Applied Microbiology and Biotechnology

Enzymatic properties, evidence for in vivo expression, and intracellular localization of shewasin D, the pepsin homolog from Shewanella denitrificans

Leal, Ana Rita; Cruz, Rui; Bur, Daniel; Huesgen, Pitter F.; Faro, Rosário; Manadas, Bruno; Wlodawer, Alexander; Faro, Carlos; Simões, Isaura, Scientific Reports. 1. 6. 2016. http://dx.doi.org/10.1038/srep23869 . 10.1038/srep23869 . Scientific Reports

Biophysical characterization of laforin–carbohydrate interaction

Dias, David M.; Furtado, Joana; Wasielewski, Emeric; Cruz, Rui; Costello, Bernard; Cole, Lindsay; Faria, Tiago Q.; et al, Biochemical Journal. 335 - 345. 3. 473. 2016. http://dx.doi.org/10.1042/bj20141555 . 10.1042/bj20141555 . Biochemical Journal

Differences in Intracellular Fate of Two Spotted Fever Group Rickettsia in Macrophage-Like Cells

Curto, Pedro; Simões, Isaura; Riley, Sean P.; Martinez, Juan J., Frontiers in Cellular and Infection Microbiology. 6. 2016. http://dx.doi.org/10.3389/fcimb.2016.00080 . 10.3389/fcimb.2016.00080 . Frontiers in Cellular and Infection Microbiology

Structure of RC1339/APRc fromRickettsia conorii, a retropepsin-like aspartic protease

Li, Mi; Gustchina, Alla; Cruz, Rui; Simões, Marisa; Curto, Pedro; Martinez, Juan; Faro, Carlos; Simões, Isaura; Wlodawer, Alexander, Acta Crystallographica Section D Biological Crystallography. 2109 - 2118. 10. 71. 2015. http://dx.doi.org/10.1107/s1399004715013905 . 10.1107/s1399004715013905 . Acta Crystallographica Section D Biological Crystallography

RC1339/APRc from Rickettsia conorii Is a Novel Aspartic Protease with Properties of Retropepsin-Like Enzymes

Cruz, Rui; Huesgen, Pitter; Riley, Sean P.; Wlodawer, Alexander; Faro, Carlos; Overall, Christopher M.; Martinez, Juan J.; Simões, Isaura, PLoS Pathogens. 8. 10. 2014. http://dx.doi.org/10.1371/journal.ppat.1004324 . 10.1371/journal.ppat.1004324 . PLoS Pathogens

Engineering a cardosin B-derived rennet for sheep and goat cheese manufacture

Almeida, Carla Malaquias; Gomes, David; Faro, Carlos; Simões, Isaura, Applied Microbiology and Biotechnology. 269 - 281. 1. 99. 2014. http://dx.doi.org/10.1007/s00253-014-5902-5 . 10.1007/s00253-014-5902-5 . Applied Microbiology and Biotechnology

Establishing the Yeast Kluyveromyces lactis as an Expression Host for Production of the Saposin-Like Domain of the Aspartic Protease Cirsin

Curto, Pedro; Lufrano, Daniela; Pinto, Cátia; Custódio, Valéria; Gomes, Ana Catarina; Trejo, Sebastián A.; Bakás, Laura; et al, Applied and Environmental Microbiology. 86 - 96. 1. 80. 2013. http://dx.doi.org/10.1128/aem.03151-13 . 10.1128/aem.03151-13 . Applied and Environmental Microbiology

Effect of a-Synuclein on Amyloid ß-Induced Toxicity: Relevance to Lewy Body Variant of Alzheimer Disease

Resende, Rosa; Marques, Sueli C. F.; Ferreiro, Elisabete; Simões, Isaura; Oliveira, Catarina R.; Pereira, Cláudia M. F., Neurochemical Research. 797 - 806. 4. 38. 2013. http://dx.doi.org/10.1007/s11064-013-0982-7 . 10.1007/s11064-013-0982-7 . Neurochemical Research

Molecular cloning and characterization of procirsin, an active aspartic protease precursor from Cirsium vulgare (Asteraceae)

Lufrano, Daniela; Faro, Rosário; Castanheira, Pedro; Parisi, Gustavo; Veríssimo, Paula; Vairo-Cavalli, Sandra; Simões, Isaura; Faro, Carlos, Phytochemistry. 7 - 18. 81. 2012. http://dx.doi.org/10.1016/j.phytochem.2012.05.028 . 10.1016/j.phytochem.2012.05.028 . Phytochemistry

Chlapsin, a chloroplastidial aspartic proteinase from the green algae Chlamydomonas reinhardtii

Almeida, Carla Malaquias; Pereira, Cláudia; da Costa, Diana Soares; Pereira, Susana; Pissarra, José; Simões, Isaura; Faro, Carlos, Planta. 283 - 296. 1. 236. 2012. http://dx.doi.org/10.1007/s00425-012-1605-2 . 10.1007/s00425-012-1605-2 . Planta

Shewasin A, an active pepsin homolog from the bacterium Shewanella amazonensis

Simões, Isaura; Faro, Rosário; Bur, Daniel; Kay, John; Faro, Carlos, FEBS Journal. 3177 - 3186. 17. 278. 2011. http://dx.doi.org/10.1111/j.1742-4658.2011.08243.x . 10.1111/j.1742-4658.2011.08243.x . FEBS Journal

Characterization of Recombinant CDR1, anArabidopsisAspartic Proteinase Involved in Disease Resistance

Simões, Isaura; Faro, Rosário; Bur, Daniel; Faro, Carlos, Journal of Biological Chemistry. 31358 - 31365. 43. 282. 2007. http://dx.doi.org/10.1074/jbc.m702477200 . 10.1074/jbc.m702477200 . Journal of Biological Chemistry

Molecular analysis of the interaction between cardosin A and phospholipase Da

Simões, Isaura; Mueller, Eva-Christina; Otto, Albrecht; Bur, Daniel; Cheung, Alice Y.; Faro, Carlos; Pires, Euclides, FEBS Journal. 5786 - 5798. 22. 272. 2005. http://dx.doi.org/10.1111/j.1742-4658.2005.04967.x . 10.1111/j.1742-4658.2005.04967.x . FEBS Journal

Structure and function of plant aspartic proteinases

Simões, Isaura; Faro, Carlos, European Journal of Biochemistry. 2067 - 2075. 11. 271. 2004. http://dx.doi.org/10.1111/j.1432-1033.2004.04136.x . 10.1111/j.1432-1033.2004.04136.x . European Journal of Biochemistry

Cloning and Characterization of cDNA Encoding Cardosin A, an RGD-containing Plant Aspartic Proteinase

Faro, Carlos; Ramalho-Santos, Miguel; Vieira, Margarida; Mendes, Alexandra; Simões, Isaura; Andrade, Rita; Veri´ssimo, Paula; et al, Journal of Biological Chemistry. 28724 - 28729. 40. 274. 1999. http://dx.doi.org/10.1074/jbc.274.40.28724 . 10.1074/jbc.274.40.28724 . Journal of Biological Chemistry

All projects

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Information of exclusive responsibility of the researcher 21-11-2021 , from platform CIÊNCIAVITAE.

2020 -

Deciphering the Rickettsia toolbox to hijack the host

ESCMID Research Grant 2020

Other

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: European Society of Clinical Microbiology and Infectious Diseases

2018/07/26 - 2021/06/26

Hijack the host or get killed: delineating Rickettsia survival strategies for development of targeted therapeutic strategies

POCI-01-0145-FEDER-029592

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2015 - 2015

Structural characterization of AtLURE1.2: an attraction molecule responsible for guiding pollen tubes to the ovular micropyle in Arabidopsis thaliana.

10029

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Instruct-ERIC

2015 - 2015

Structural characterization of the soluble domain of APRc, a novel membrane embedded retropepsin-like aspartic protease from the pathogenic bacteria Rickettsia conorii.

PID: 1310

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Instruct-ERIC

2015 - 2017

Plant Aspartic Protease Substrate Identification

Project 6818

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia; Deutscher Akademischer Austauschdienst

2014/12/01 - 2017/04

The retropepsin-like enzyme RC1339/APRick from Rickettsiae as a potential therapeutic target for rickettsial diseases

1R21-AI111086

Research Fellow

Louisiana State University School of Veterinary Medicine

Funders: National Institutes of Health Office of Extramural Research

2010/04 - 2013/06

RECOMBINANT PLANT-DERIVED RENNETS FOR CHEESE INDUSTRY

102540

Supervisor

Biocant Associação de Transferência de Tecnologia

Funders: Fundação para a Ciência e a Tecnologia, I.P.

2010/04/01 - 2013/07/31

Retroviral-like membrane-associated aspartic proteinases from Rickettsiae: potential new therapeutic targets for rickettsioses.

107942

Principal investigator

Biocant Associação de Transferência de Tecnologia

Funders: Fundação para a Ciência e a Tecnologia, I.P.

2007 - 2009

Generating a rennet substitute of plant origin based on the natural diversity of cardosin-like proteases.

Biocant/Rennet/2007

Principal investigator

Biocant Associação de Transferência de Tecnologia

Funders: Biocant Ventures

2003 - 2006

Aspartic proteinase content of Arabidopsis genome: identification, expression and characterization

POCTI/BCI/48400/2002

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia; Biocant Ventures

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