Affiliation

Center for Neuroscience and Cell Biology, University of Coimbra, Pólo I - Edifício da FMUC, Rua Larga 3004-504 Coimbra

Publications

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Information about journal articles, updated at 21-11-2021, from platform CIÊNCIAVITAE.

MiR-200c-based metabolic modulation in glioblastoma cells as a strategy to overcome tumor chemoresistance

Cardoso, Ana M; Morais, Catarina M; Sousa, Madalena; Rebelo, Olinda; Tão, Hermínio; Barbosa, Marcos; Pedroso de Lima, Maria C; Jurado, Amália S, Human Molecular Genetics. 2021. http://dx.doi.org/10.1093/hmg/ddab193 . 10.1093/hmg/ddab193 . Human Molecular Genetics

Improving pollutants environmental risk assessment using a multi model toxicity determination with in vitro, bacterial, animal and plant model systems: The case of the herbicide alachlor

Pereira, S.P.; Santos, S.M.A.; Fernandes, M.A.S.; Deus, C.M.; Martins, J.D.; Pedroso de Lima, M.C.; Vicente, J.A.F.; Videira, R.A.; Jurado, A.S., Environmental Pollution. 286. 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85105603093&partnerID=MN8TOARS . 10.1016/j.envpol.2021.117239 . Environmental Pollution

Downregulation of long non-protein coding RNA MVIH impairs glioblastoma cell proliferation and invasion through an miR-302a-dependent mechanism

Cardoso, Ana M; Morais, Catarina M; Rebelo, Olinda; Tão, Hermínio; Barbosa, Marcos; Pedroso de Lima, Maria C; Jurado, Amália S, Human Molecular Genetics. 46 - 64. 1. 30. 2021. http://dx.doi.org/10.1093/hmg/ddab009 . 10.1093/hmg/ddab009 . Human Molecular Genetics

Differentiation of glioblastoma stem cells promoted by miR-128 or miR-302a overexpression enhances senescence-associated cytotoxicity of axitinib

Ana Cardoso, Human Molecular Genetics . 160 - 171. 30. 2021. doi: 10.1093/hmg/ddab011. . Human Molecular Genetics

Lauroylated Histidine-Enriched S413-PV Peptide as an Efficient Gene Silencing Mediator in Cancer Cells

Morais, Catarina M.; Cardoso, Ana M.; Aguiar, Luísa; Vale, Nuno; Nóbrega, Clévio; Zuzarte, Mónica; Gomes, Paula; Pedroso de Lima, Maria C.; Jurado, Amália S., Pharmaceutical Research. 10. 37. 2020. http://dx.doi.org/10.1007/s11095-020-02904-x . 10.1007/s11095-020-02904-x . Pharmaceutical Research

Physicochemical characterization and targeting performance of triphenylphosphonium nano-polyplexes

Faria, Rúben; Albuquerque, Tânia; Neves, Ana R.; Bhatt, Himanshu; Biswas, Swati; Cardoso, Ana M.; Pedroso de Lima, Maria C.; Jurado, Amália S.; Costa, Diana, Journal of Molecular Liquids. 316. 2020. http://dx.doi.org/10.1016/j.molliq.2020.113873 . 10.1016/j.molliq.2020.113873 . Journal of Molecular Liquids

Lysosomal Storage Disease-Associated Neuropathy: Targeting Stable Nucleic Acid Lipid Particle (SNALP)-Formulated siRNAs to the Brain as a Therapeutic Approach

Coutinho, Maria Francisca; Santos, Juliana Inês; S. Mendonça, Liliana; Matos, Liliana; Prata, Maria João; S. Jurado, Amália; Pedroso de Lima, Maria C.; Alves, Sandra, International Journal of Molecular Sciences. 16. 21. 2020. http://dx.doi.org/10.3390/ijms21165732 . 10.3390/ijms21165732 . International Journal of Molecular Sciences

Glucosylceramide synthase silencing combined with the receptor tyrosine kinase inhibitor axitinib as a new multimodal strategy for glioblastoma

Morais, C.M.; Cunha, P.P.; Melo, T.; Cardoso, A.M.; Domingues, P.; Domingues, M.R.; Pedroso de Lima, M.C.; Jurado, A.S., Human Molecular Genetics. 3664 - 3679. 21. 28. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85077223998&partnerID=MN8TOARS . 10.1093/hmg/ddz152 . Human Molecular Genetics

Acylation of the S4<inf>13</inf>-PV cell-penetrating peptide as a means of enhancing its capacity to mediate nucleic acid delivery: Relevance of peptide/lipid interactions

Morais, C.M.; Cardoso, A.M.; Cunha, P.P.; Aguiar, L.; Vale, N.; Lage, E.; Pinheiro, M.; et al, Biochimica et Biophysica Acta - Biomembranes. 2619 - 2634. 12. 1860. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85054439165&partnerID=MN8TOARS . 10.1016/j.bbamem.2018.10.002 . Biochimica et Biophysica Acta - Biomembranes

Mechanistic study of the adjuvant effect of chitosan-aluminum nanoparticles

Lebre, F.; Pedroso de Lima, M.C.; Lavelle, E.C.; Borges, O., International Journal of Pharmaceutics. 7 - 15. 1-2. 552. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85053833190&partnerID=MN8TOARS . 10.1016/j.ijpharm.2018.09.044 . International Journal of Pharmaceutics

Multimodal highly fluorescent-magnetic nanoplatform to target transferrin receptors in cancer cells

Cabral Filho, P.E.; Cabrera, M.P.; Cardoso, A.L.C.; Santana, O.A.; Geraldes, C.F.G.C.; Santos, B.S.; Pedroso de Lima, M.C.; Pereira, G.A.L.; Fontes, A., Biochimica et Biophysica Acta - General Subjects. 2788 - 2796. 12. 1862. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85052949793&partnerID=MN8TOARS . 10.1016/j.bbagen.2018.08.014 . Biochimica et Biophysica Acta - General Subjects

Resveratrol stimulates the metabolic reprogramming of human CD4+T cells to enhance effector function

Marco Craveiro; Gaspard Cretenet; Cédric Mongellaz; Maria I. Matias; Olivier Caron; Maria C. Pedroso de Lima; Valérie S. Zimmermann; et al, Science Signaling. eaal3024 - eaal3024. 501. 10. 2017. https://doi.org/10.1126/scisignal.aal3024 . 10.1126/scisignal.aal3024 . Science Signaling

Association of chitosan and aluminium as a new adjuvant strategy for improved vaccination

Lebre, F.; Bento, D.; Ribeiro, J.; Colaço, M.; Borchard, G.; Pedroso De Lima, M.C.P.; Borges, O., International Journal of Pharmaceutics. 103 - 114. 1-2. 527. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85019758926&partnerID=MN8TOARS . 10.1016/j.ijpharm.2017.05.028 . International Journal of Pharmaceutics

High-throughput screening uncovers miRNAs enhancing glioblastoma cell susceptibility to tyrosine kinase inhibitors

Pedro P Cunha; Pedro M Costa; Catarina M Morais; Inês R Lopes; Ana M Cardoso; Ana L Cardoso; Miguel Mano; Amália S Jurado; Maria C Pedroso de Lima, Human Molecular Genetics. 4375 - 4387. 22. 26. 2017. https://doi.org/10.1093/hmg/ddx323 . 10.1093/hmg/ddx323 . Human Molecular Genetics

CdTe quantum dots as fluorescent probes to study transferrin receptors in glioblastoma cells

Cabral Filho, P.E.; Cardoso, A.L.C.; Pereira, M.I.A.; Ramos, A.P.M.; Hallwas, F.; Castro, M.M.C.A.; Geraldes, C.F.G.C.; et al, Biochimica et Biophysica Acta - General Subjects. 28 - 35. 1. 1860. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84946430431&partnerID=MN8TOARS . 10.1016/j.bbagen.2015.09.021 . Biochimica et Biophysica Acta - General Subjects

Safety profile of the intravenous administration of brain-targeted stable nucleic acid lipid particles

Conceição, M.; Mendonça, L.; Nóbrega, C.; Gomes, C.; Costa, P.; Hirai, H.; Moreira, J.N.; et al, Data in Brief. 700 - 705. 6. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84956617357&partnerID=MN8TOARS . 10.1016/j.dib.2016.01.017 . Data in Brief

Intranasal Administration of Novel Chitosan Nanoparticle/DNA Complexes Induces Antibody Response to Hepatitis B Surface Antigen in Mice

Lebre, F.; Borchard, G.; Faneca, H.; Pedroso De Lima, M.C.; Borges, O., Molecular Pharmaceutics. 472 - 482. 2. 13. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84957308940&partnerID=MN8TOARS . 10.1021/acs.molpharmaceut.5b00707 . Molecular Pharmaceutics

Role of microRNAs in the regulation of innate immune cells under neuroinflammatory conditions

Cardoso, A.L.; Guedes, J.R.; De Lima, M.C.P., Current Opinion in Pharmacology. 1 - 9. 26. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84942921906&partnerID=MN8TOARS . 10.1016/j.coph.2015.09.001 . Current Opinion in Pharmacology

Enhancing glioblastoma cell sensitivity to chemotherapeutics: A strategy involving survivin gene silencing mediated by gemini surfactant-based complexes

Cruz, R.Q.; Morais, C.M.; Cardoso, A.M.; Silva, S.G.; Vale, M.L.; Marques, E.F.; Pedroso De Lima, M.C.; Jurado, A.S., European Journal of Pharmaceutics and Biopharmaceutics. 7 - 18. 104. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84964330230&partnerID=MN8TOARS . 10.1016/j.ejpb.2016.04.014 . European Journal of Pharmaceutics and Biopharmaceutics

Intravenous administration of brain-targeted stable nucleic acid lipid particles alleviates Machado-Joseph disease neurological phenotype

Conceição, M.; Mendonça, L.; Nóbrega, C.; Gomes, C.; Costa, P.; Hirai, H.; Moreira, J.N.; et al, Biomaterials. 124 - 137. 82. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84956644943&partnerID=MN8TOARS . 10.1016/j.biomaterials.2015.12.021 . Biomaterials

MicroRNA deregulation and chemotaxis and phagocytosis impairment in Alzheimer's disease

Guedes, J.R.; Santana, I.; Cunha, C.; Duro, D.; Almeida, M.R.; Cardoso, A.M.; de Lima, M.C.P.; Cardoso, A.L., Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 7 - 17. 3. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84956620147&partnerID=MN8TOARS . 10.1016/j.dadm.2015.11.004 . Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

New serine-derived gemini surfactants as gene delivery systems

Cardoso, A.M.; Morais, C.M.; Cruz, A.R.; Silva, S.G.; Do Vale, M.L.; Marques, E.F.; De Lima, M.C.P.; Jurado, A.S., European Journal of Pharmaceutics and Biopharmaceutics. 347 - 356. 89. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84920830778&partnerID=MN8TOARS . 10.1016/j.ejpb.2014.12.013 . European Journal of Pharmaceutics and Biopharmaceutics

MicroRNAs in glioblastoma: Role in pathogenesis and opportunities for targeted therapies

Costa, P.M.; Cardoso, A.L.; Mano, M.; de Lima, M.C.P., CNS and Neurological Disorders - Drug Targets. 222 - 238. 2. 14. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930907378&partnerID=MN8TOARS . 10.2174/1871527314666150116123610 . CNS and Neurological Disorders - Drug Targets

Gemini Surfactants Mediate Efficient Mitochondrial Gene Delivery and Expression

Cardoso, A.M.; Morais, C.M.; Cruz, A.R.; Cardoso, A.L.; Silva, S.G.; Do Vale, M.L.; Marques, E.F.; Pedroso De Lima, M.C.; Jurado, A.S., Molecular Pharmaceutics. 716 - 730. 3. 12. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84924023696&partnerID=MN8TOARS . 10.1021/mp5005349 . Molecular Pharmaceutics

MiRNA-21 silencing mediated by tumor-targeted nanoparticles combined with sunitinib: A new multimodal gene therapy approach for glioblastoma

Costa, P.M.; Cardoso, A.L.; Custódia, C.; Cunha, P.; Pereira De Almeida, L.; Pedroso De Lima, M.C., Journal of Controlled Release. 31 - 39. 207. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84926665383&partnerID=MN8TOARS . 10.1016/j.jconrel.2015.04.002 . Journal of Controlled Release

Bis-quaternary gemini surfactants as components of nonviral gene delivery systems: A comprehensive study from physicochemical properties to membrane interactions

Cardoso, A.M.; Morais, C.M.; Silva, S.G.; Marques, E.F.; De Lima, M.C.P.; Jurado, M.A.S., International Journal of Pharmaceutics. 57 - 69. 1-2. 474. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84906267891&partnerID=MN8TOARS . 10.1016/j.ijpharm.2014.08.011 . International Journal of Pharmaceutics

Early miR-155 upregulation contributes to neuroinflammation in Alzheimer's disease triple transgenic mouse model.

Maria C. Pedroso de Lima, Human Molecular Genetics. 2014. http://www.ncbi.nlm.nih.gov/pubmed/24990149 . 10.1093/hmg/ddu348 . Human Molecular Genetics

MicroRNA modulation combined with sunitinib as a novel therapeutic strategy for pancreatic cancer

Henrique Faneca; Marta Passadouro; Maria Pedroso de Lima, International Journal of Nanomedicine. 3203 - 3203. 2014. https://doi.org/10.2147%2Fijn.s64456 . 10.2147/ijn.s64456 . International Journal of Nanomedicine

Sustained release of naltrexone from Poly(N-Isopropylacrylamide) microgels

Kjøniksen, A.-L.; Calejo, M.T.; Zhu, K.; Cardoso, A.M.S.; De Lima, M.C.P.; Jurado, A.S.; Nyström, B.; Sande, S.A., Journal of Pharmaceutical Sciences. 227 - 234. 1. 103. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84890551451&partnerID=MN8TOARS . 10.1002/jps.23780 . Journal of Pharmaceutical Sciences

Increased gene delivery efficiency and specificity of a lipid-based nanosystem incorporating a glycolipid

Magalhães, M.; Farinha, D.; de Lima, M.C.P.; Faneca, H., International Journal of Nanomedicine. 4979 - 4989. 9. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930260157&partnerID=MN8TOARS . 10.2147/IJN.S69822 . International Journal of Nanomedicine

MicroRNA modulation combined with sunitinib as a novel therapeutic strategy for pancreatic cancer

Passadouro, M.; Pedroso de Lima, M.C.; Faneca, H., International Journal of Nanomedicine. 3203 - 3217. 1. 9. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903878322&partnerID=MN8TOARS . 10.2147/IJN.S64456 . International Journal of Nanomedicine

Specific and efficient gene delivery mediated by an asialofetuin-associated nanosystem

Farinha, D.; Pedroso De Lima, M.C.; Faneca, H., International Journal of Pharmaceutics. 366 - 374. 1-2. 473. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84904968165&partnerID=MN8TOARS . 10.1016/j.ijpharm.2014.07.019 . International Journal of Pharmaceutics

Application of thermoresponsive PNIPAAM-b-PAMPTMA diblock copolymers in siRNA delivery

Cardoso, A.M.; Calejo, M.T.; Morais, C.M.; Cardoso, A.L.; Cruz, R.; Zhu, K.; Pedroso De Lima, M.C.; Jurado, A.S.; Nyström, B., Molecular Pharmaceutics. 819 - 827. 3. 11. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901742907&partnerID=MN8TOARS . 10.1021/mp400510a . Molecular Pharmaceutics

Impact of anti-PLK1 siRNA-containing F3-targeted liposomes on the viability of both cancer and endothelial cells

Gomes-Da-Silva, L.C.; Ramalho, J.S.; Pedroso De Lima, M.C.; Simões, S.; Moreira, J.N., European Journal of Pharmaceutics and Biopharmaceutics. 356 - 364. 3 PART A. 85. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84888308868&partnerID=MN8TOARS . 10.1016/j.ejpb.2013.04.007 . European Journal of Pharmaceutics and Biopharmaceutics

Micrornas as molecular targets for cancer therapy: On the modulation of microrna expression

Costa, P.M.; De Lima, M.C.P., Pharmaceuticals. 1195 - 1220. 10. 6. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885029680&partnerID=MN8TOARS . 10.3390/ph6101195 . Pharmaceuticals

Tumor-targeted chlorotoxin-coupled nanoparticles for nucleic acid delivery to glioblastoma cells: A promising system for glioblastoma treatment

Costa, P.M.; Cardoso, A.L.; Mendonça, L.S.; Serani, A.; Custódia, C.; Conceição, M.; Simões, S.; et al, Molecular Therapy - Nucleic Acids. 2. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879940866&partnerID=MN8TOARS . 10.1038/mtna.2013.30 . Molecular Therapy - Nucleic Acids

Impact of PLK-1 silencing on endothelial cells and cancer cells of diverse histological origin

Gomes, C.P.; Gomes-da-Silva, L.C.; Ramalho, J.S.; de Lima, M.C.P.; Simões, S.; Moreira, J.N., Current Gene Therapy. 189 - 201. 3. 13. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878633310&partnerID=MN8TOARS . 10.2174/1566523211313030004 . Current Gene Therapy

Preventive cancer stem cell-based vaccination reduces liver metastasis development in a rat colon carcinoma syngeneic model

Duarte, S.; Momier, D.; Baqué, P.; Casanova, V.; Loubat, A.; Samson, M.; Guigonis, J.-M.; et al, Stem Cells. 423 - 432. 3. 31. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874818661&partnerID=MN8TOARS . 10.1002/stem.1292 . Stem Cells

In vitro cytotoxicity of a thermoresponsive gel system combining ethyl(hydroxyethyl) cellulose and lysine-based surfactants

Calejo, M.T.; Cardoso, A.M.S.; Marques, E.F.; Araújo, M.J.; Kjøniksen, A.-L.; Sande, S.A.; de Lima, M.C.P.; Jurado, A.S.; Nyström, B., Colloids and Surfaces B: Biointerfaces. 682 - 686. 102. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867835593&partnerID=MN8TOARS . 10.1016/j.colsurfb.2012.09.033 . Colloids and Surfaces B: Biointerfaces

Comparison of the efficiency of complexes based on S4<inf>13</inf>-PV cell-penetrating peptides in plasmid DNA and siRNA delivery

Cardoso, A.M.; Trabulo, S.; Cardoso, A.L.; Maia, S.; Gomes, P.; Jurado, A.S.; Pedroso De Lima, M.C., Molecular Pharmaceutics. 2653 - 2666. 7. 10. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879735661&partnerID=MN8TOARS . 10.1021/mp400078h . Molecular Pharmaceutics

Cell-penetrating peptides as nucleic acid delivery systems: From biophysics to biological applications

Trabulo, S.; Cardoso, A.L.; Cardoso, A.M.S.; Morais, C.M.; Jurado, A.S.; Pedroso de Lima, M.C., Current Pharmaceutical Design. 2895 - 2923. 16. 19. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878655380&partnerID=MN8TOARS . 10.2174/1381612811319160006 . Current Pharmaceutical Design

Synthesis of gemini surfactants and evaluation of their interfacial and cytotoxic properties: Exploring the multifunctionality of serine as headgroup

Silva, S.G.; Alves, C.; Cardoso, A.M.S.; Jurado, A.S.; Pedroso De Lima, M.C.; Vale, M.L.C.; Marques, E.F., European Journal of Organic Chemistry. 1758 - 1769. 9. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875008251&partnerID=MN8TOARS . 10.1002/ejoc.201201396 . European Journal of Organic Chemistry

MicroRNA-21 silencing enhances the cytotoxic effect of the antiangiogenic drug sunitinib in glioblastoma

Costa, P.M.; Cardoso, A.L.; Nóbrega, C.; Pereira de almeida, L.F.; Bruce, J.N.; Canoll, P.; Pedroso de Lima, M.C., Human Molecular Genetics. 904 - 918. 5. 22. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873438180&partnerID=MN8TOARS . 10.1093/hmg/dds496 . Human Molecular Genetics

Involvement of MicroRNA in microglia-mediated immune response

Guedes, J.; Cardoso, A.L.C.; Pedroso De Lima, M.C., Clinical and Developmental Immunology. 2013. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878648745&partnerID=MN8TOARS . 10.1155/2013/186872 . Clinical and Developmental Immunology

Efficient intracellular delivery of siRNA with a safe multitargeted lipid-based nanoplatform

Gomes-Da-Silva, L.C.; Fernández, Y.; Abasolo, I.; Schwartz, S.; Ramalho, J.S.; Pedroso De Lima, M.C.; Simões, S.; Moreira, J.N., Nanomedicine. 1397 - 1413. 9. 8. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84893195240&partnerID=MN8TOARS . 10.2217/nnm.12.174 . Nanomedicine

Temperature-responsive cationic block copolymers as nanocarriers for gene delivery

Calejo, M.T.; Cardoso, A.M.S.; Kjøniksen, A.-L.; Zhu, K.; Morais, C.M.; Sande, S.A.; Cardoso, A.L.; et al, International Journal of Pharmaceutics. 105 - 114. 1. 448. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875930565&partnerID=MN8TOARS . 10.1016/j.ijpharm.2013.03.028 . International Journal of Pharmaceutics

Folate-associated lipoplexes mediate efficient gene delivery and potent antitumoral activity in vitro and in vivo

Duarte, S.; Faneca, H.; Lima, M.C.P.D., International Journal of Pharmaceutics. 365 - 377. 2. 423. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856552664&partnerID=MN8TOARS . 10.1016/j.ijpharm.2011.12.035 . International Journal of Pharmaceutics

Toward a siRNA-containing nanoparticle targeted to breast cancer cells and the tumor microenvironment

Gomes-Da-Silva, L.C.; Santos, A.O.; Bimbo, L.M.; Moura, V.; Ramalho, J.S.; Pedroso De Lima, M.C.; Simões, S.; Moreira, J.N., International Journal of Pharmaceutics. 9 - 19. 1-2. 434. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864129727&partnerID=MN8TOARS . 10.1016/j.ijpharm.2012.05.018 . International Journal of Pharmaceutics

Thermoresponsive hydrogels with low toxicity from mixtures of ethyl(hydroxyethyl) cellulose and arginine-based surfactants

Calejo, M.T.; Kjoniksen, A.-L.; Pinazo, A.; Pérez, L.; Cardoso, A.M.S.; Pedroso De Lima, M.C.; Jurado, A.S.; Sande, S.A.; Nyström, B., International Journal of Pharmaceutics. 454 - 462. 1-2. 436. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865288628&partnerID=MN8TOARS . 10.1016/j.ijpharm.2012.07.018 . International Journal of Pharmaceutics

PDGF-B-mediated downregulation of miR-21: New insights into PDGF signaling in glioblastoma

Costa, P.M.; Cardoso, A.L.; Pereira de almeida, L.F.; Bruce, J.N.; Canoll, P.; Pedroso de lima, M.C., Human Molecular Genetics. 5118 - 5130. 23. 21. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84869025536&partnerID=MN8TOARS . 10.1093/hmg/dds358 . Human Molecular Genetics

Targeted lipid-based systems for siRNA delivery

Mendonça, L.S.; Pedroso De Lima, M.C.; Simöes, S., Journal of Drug Delivery Science and Technology. 65 - 73. 1. 22. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857427765&partnerID=MN8TOARS . Journal of Drug Delivery Science and Technology

miR-155 modulates microglia-mediated immune response by down-regulating SOCS-1 and promoting cytokine and nitric oxide production

Cardoso, A.L.; Guedes, J.R.; Pereira de Almeida, L.; Pedroso de Lima, M.C., Immunology. 73 - 88. 1. 135. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-83055176904&partnerID=MN8TOARS . 10.1111/j.1365-2567.2011.03514.x . Immunology

S4(13)-PV cell-penetrating peptide induces physical and morphological changes in membrane-mimetic lipid systems and cell membranes: Implications for cell internalization

Cardoso, A.M.S.; Trabulo, S.; Cardoso, A.L.; Lorents, A.; Morais, C.M.; Gomes, P.; Nunes, C.; et al, Biochimica et Biophysica Acta - Biomembranes. 877 - 888. 3. 1818. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856059612&partnerID=MN8TOARS . 10.1016/j.bbamem.2011.12.022 . Biochimica et Biophysica Acta - Biomembranes

Lipid-based nanoparticles for siRNA delivery in cancer therapy: Paradigms and challenges

Gomes-Da-Silva, L.C.; Fonseca, N.A.; Moura, V.; Pedroso De Lima, M.C.; Simões, S.; Moreira, J.N., Accounts of Chemical Research. 1163 - 1171. 7. 45. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863922166&partnerID=MN8TOARS . 10.1021/ar300048p . Accounts of Chemical Research

Targeted and intracellular triggered delivery of therapeutics to cancer cells and the tumor microenvironment: Impact on the treatment of breast cancer

Moura, V.; Lacerda, M.; Figueiredo, P.; Corvo, M.L.; Cruz, M.E.M.; Soares, R.; De Lima, M.C.P.; Simões, S.; Moreira, J.N., Breast Cancer Research and Treatment. 61 - 73. 1. 133. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860334520&partnerID=MN8TOARS . 10.1007/s10549-011-1688-7 . Breast Cancer Research and Treatment

Isolation of head and neck squamous carcinoma cancer stem-like cells in a syngeneic mouse model and analysis of hypoxia effect

Duarte, S.; Loubat, A.; Momier, D.; Topi, M.; Faneca, H.; Pedroso De Lima, M.C.; Carle, G.F.; Pierrefite-Carle, V., Oncology Reports. 1057 - 1062. 3. 28. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865312688&partnerID=MN8TOARS . 10.3892/or.2012.1904 . Oncology Reports

Suicide gene therapy in cancer: Where do we stand now?

Duarte, S.; Carle, G.; Faneca, H.; Lima, M.C.P.D.; Pierrefite-Carle, V., Cancer Letters. 160 - 170. 2. 324. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864392111&partnerID=MN8TOARS . 10.1016/j.canlet.2012.05.023 . Cancer Letters

Gemini surfactant dimethylene-1,2-bis(tetradecyldimethylammonium bromide)-based gene vectors: A biophysical approach to transfection efficiency

Cardoso, A.M.S.; Faneca, H.; Almeida, J.A.S.; Pais, A.A.C.C.; Marques, E.F.; De Lima, M.C.P.; Jurado, A.S., Biochimica et Biophysica Acta - Biomembranes. 341 - 351. 1. 1808. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-78649777308&partnerID=MN8TOARS . 10.1016/j.bbamem.2010.09.026 . Biochimica et Biophysica Acta - Biomembranes

Progress towards a needle-free hepatitis B vaccine

Lebre, F.; Borchard, G.; De Lima, M.C.P.; Borges, O., Pharmaceutical Research. 986 - 1012. 5. 28. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955607675&partnerID=MN8TOARS . 10.1007/s11095-010-0314-4 . Pharmaceutical Research

In situ forming chitosan hydrogels prepared via ionic/covalent Co-cross-linking

Moura, M.J.; Faneca, H.; Lima, M.P.; Gil, M.H.; Figueiredo, M.M., Biomacromolecules. 3275 - 3284. 9. 12. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80052771947&partnerID=MN8TOARS . 10.1021/bm200731x . Biomacromolecules

Inclusion of a single-tail amino acid-based amphiphile in a lipoplex formulation: Effects on transfection efficiency and physicochemical properties

Lundberg, D.; Faneca, H.; MorÁn, M.D.C.; Pedroso De Lima, M.C.; Miguel, M.D.G.; Lindman, B., Molecular Membrane Biology. 42 - 53. 1. 28. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-78651279670&partnerID=MN8TOARS . 10.3109/09687688.2010.508879 . Molecular Membrane Biology

Non-covalent association of folate to lipoplexes: A promising strategy to improve gene delivery in the presence of serum

Duarte, S.; Faneca, H.; Pedroso De Lima, M.C., Journal of Controlled Release. 264 - 272. 3. 149. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79951941675&partnerID=MN8TOARS . 10.1016/j.jconrel.2010.10.032 . Journal of Controlled Release

Survivin silencing as a promising strategy to enhance the sensitivity of cancer cells to chemotherapeutic agents

Trabulo, S.; Cardoso, A.M.; Santos-Ferreira, T.; Cardoso, A.L.; Simões, S.; Pedroso De Lima, M.C., Molecular Pharmaceutics. 1120 - 1131. 4. 8. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79961082146&partnerID=MN8TOARS . 10.1021/mp100426e . Molecular Pharmaceutics

Interaction of proteinase inhibitors with phospholipid vesicles is modulated by pH

Silva-Lucca, R.A.; Faneca, H.M.S.; de Lima, M.C.P.; De Caroli, F.P.; Assis, M.L.; Sampaio, M.U.; Oliva, M.L.V., International Journal of Biological Macromolecules. 551 - 557. 4. 47. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956717001&partnerID=MN8TOARS . 10.1016/j.ijbiomac.2010.07.011 . International Journal of Biological Macromolecules

Transferrin receptor-targeted liposomes encapsulating anti-BCR-ABL siRNA or asodn for chronic myeloid leukemia treatment

Mendonça, L.S.; Firmino, F.; Moreira, J.N.; De Lima, M.C.P.; Simões, S., Bioconjugate Chemistry. 157 - 168. 1. 21. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-74949127407&partnerID=MN8TOARS . 10.1021/bc9004365 . Bioconjugate Chemistry

Design of peptide-targeted liposomes containing nucleic acids

Santos, A.O.; da Silva, L.C.G.; Bimbo, L.M.; de Lima, M.C.P.; Simões, S.; Moreira, J.N., Biochimica et Biophysica Acta - Biomembranes. 433 - 441. 3. 1798. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-76749124054&partnerID=MN8TOARS . 10.1016/j.bbamem.2009.12.001 . Biochimica et Biophysica Acta - Biomembranes

Physicochemical properties of transferrin-associated lipopolyplexes and their role in biological activity

Penacho, N.; Rosa, M.; Lindman, B.; Miguel, M.G.; Simões, S.; de Lima, M.C.P., Colloids and Surfaces B: Biointerfaces. 207 - 214. 1. 76. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-74149085531&partnerID=MN8TOARS . 10.1016/j.colsurfb.2009.10.034 . Colloids and Surfaces B: Biointerfaces

Cell-penetrating peptides-mechanisms of cellular uptake and generation of delivery systems

Trabulo, S.; Cardoso, A.L.; Mano, M.; de Lima, M.C.P., Pharmaceuticals. 961 - 993. 4. 3. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952146840&partnerID=MN8TOARS . 10.3390/ph3040961 . Pharmaceuticals

Silencing ataxin-3 mitigates degeneration in a rat model of Machado-Joseph disease: No role for wild-type ataxin-3?

Alves, S.; Nascimento-Ferreira, I.; Dufour, N.; Hassig, R.; Auregan, G.; Nóbrega, C.; Brouillet, E.; et al, Human Molecular Genetics. 2380 - 2394. 12. 19. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955290123&partnerID=MN8TOARS . 10.1093/hmg/ddq111 . Human Molecular Genetics

A non-covalent strategy combining cationic lipids and CPPs to enhance the delivery of splice correcting oligonucleotides

Trabulo, S.; Resina, S.; Simões, S.; Lebleu, B.; Pedroso de Lima, M.C., Journal of Controlled Release. 149 - 158. 2. 145. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953961849&partnerID=MN8TOARS . 10.1016/j.jconrel.2010.03.021 . Journal of Controlled Release

In vitro modulation of Bcl-2 levels in small cell lung cancer cells: Effects on cell viability

Santos, A.O.; Pereira, J.P.; Pedroso de Lima, M.C.; Simões, S.; Moreira, J.N., Brazilian Journal of Medical and Biological Research. 1001 - 1009. 10. 43. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-78149263712&partnerID=MN8TOARS . 10.1590/S0100-879X2010007500099 . Brazilian Journal of Medical and Biological Research

Methods to monitor liposome fusion, permeability, and interaction with cells.

Düzgünes, N.; Faneca, H.; Lima, M.C., Methods in molecular biology (Clifton, N.J.). 209 - 232. 606. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77649218400&partnerID=MN8TOARS . 10.1007/978-1-60761-447-0_16 . Methods in molecular biology (Clifton, N.J.)

S4<inf>13</inf>-PV cell-penetrating peptide forms nanoparticle-like structures to gain entry into cells

Padari, K.; Koppel, K.; Lorents, A.; Hällbrink, M.; Mano, M.; Pedroso De Lima, M.C.; Pooga, M., Bioconjugate Chemistry. 774 - 783. 4. 21. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77951285705&partnerID=MN8TOARS . 10.1021/bc900577e . Bioconjugate Chemistry

Co-encapsulation of anti-BCR-ABL siRNA and imatinib mesylate in transferrin receptor-targeted sterically stabilized liposomes for chronic myeloid leukemia treatment

Mendonça, L.S.; Moreira, J.N.; De Lima, M.C.P.; Simões, S., Biotechnology and Bioengineering. 884 - 893. 5. 107. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77958590068&partnerID=MN8TOARS . 10.1002/bit.22858 . Biotechnology and Bioengineering

Tf-lipoplex-mediated c-Jun silencing improves neuronal survival following excitotoxic damage in vivo

Cardoso, A.L.C.; Costa, P.; de Almeida, L.P.; Simões, S.; Plesnila, N.; Culmsee, C.; Wagner, E.; Pedroso de Lima, M.C., Journal of Controlled Release. 392 - 403. 3. 142. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77349098528&partnerID=MN8TOARS . 10.1016/j.jconrel.2009.11.004 . Journal of Controlled Release

Polyethylenimine of various molecular weights as adjuvant for transfection mediated by cationic liposomes

Penacho, N.; Simões, S.; De Lima, M.P., Molecular Membrane Biology. 249 - 263. 4. 26. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-67650308758&partnerID=MN8TOARS . 10.1080/09687680902766716 . Molecular Membrane Biology

Vanadium compounds as therapeutic agents: Some chemical and biochemical studies

Faneca, H.; Figueiredo, V.A.; Tomaz, I.; Gonçalves, G.; Avecilla, F.; Pedroso de Lima, M.C.; Geraldes, C.F.G.C.; Pessoa, J.C.; Castro, M.M.C.A., Journal of Inorganic Biochemistry. 601 - 608. 4. 103. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-62349102649&partnerID=MN8TOARS . 10.1016/j.jinorgbio.2008.11.004 . Journal of Inorganic Biochemistry

Transferrin lipoplex-mediated suicide gene therapy of oral squamous cell carcinoma in an immunocompetent murine model and mechanisms involved in the antitumoral response

Neves, S.; Faneca, H.; Bertin, S.; Konopka, K.; Düzgünes, N.; Pierrefite-Carle, V.; Simões, S.; Pedroso De Lima, M.C., Cancer Gene Therapy. 91 - 101. 1. 16. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-57649131464&partnerID=MN8TOARS . 10.1038/cgt.2008.60 . Cancer Gene Therapy

Synergistic antitumoral effect of vinblastine and HSV-Tk/GCV gene therapy mediated by albumin-associated cationic liposomes

Faneca, H.; Faustino, A.; Pedroso de Lima, M.C., Journal of Controlled Release. 175 - 184. 2. 126. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-38749101958&partnerID=MN8TOARS . 10.1016/j.jconrel.2007.12.005 . Journal of Controlled Release

African swine fever virus p10 protein exhibits nuclear import capacity and accumulates in the nucleus during viral infection

Nunes-Correia, I.; Rodríguez, J.M.; Eulálio, A.; Carvalho, A.L.; Citovsky, V.; Simões, S.; Faro, C.; Salas, M.L.; Pedroso de Lima, M.C., Veterinary Microbiology. 47 - 59. 1-2. 130. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-46549086170&partnerID=MN8TOARS . 10.1016/j.vetmic.2007.12.010 . Veterinary Microbiology

Allele-specific RNA silencing of mutant ataxin-3 mediates neuroprotection in a rat model of Machado-Joseph disease

Alves, S.; Nascimento-Ferreira, I.; Auregan, G.; Hassig, R.; Dufour, N.; Brouillet, E.; Pedroso de Lima, M.C.; et al, PLoS ONE. 10. 3. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-54449095083&partnerID=MN8TOARS . 10.1371/journal.pone.0003341 . PLoS ONE

S4<inf>13</inf>-PV cell penetrating peptide and cationic liposomes act synergistically to mediate intracellular delivery of plasmid DNA

Trabulo, S.; Mano, M.; Faneca, H.; Cardoso, A.L.; Duarte, S.; Henriques, A.; Paiva, A.; et al, Journal of Gene Medicine. 1210 - 1222. 11. 10. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-58149190435&partnerID=MN8TOARS . 10.1002/jgm.1247 . Journal of Gene Medicine

Simultaneous evaluation of viability and Bcl-2 in small-cell lung cancer

Santos, A.; Sarmento-Ribeiro, A.B.; Pedroso De Lima, M.C.; Simões, S.; Moreira, J.N., Cytometry Part A. 1165 - 1172. 12. 73. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-56749165193&partnerID=MN8TOARS . 10.1002/cyto.a.20634 . Cytometry Part A

Transferrin-associated lipoplexes as gene delivery systems: Relevance of mode of preparation and biophysical properties

Penacho, N.; Filipe, A.; Simões, S.; Pedroso De Lima, M.C., Journal of Membrane Biology. 141 - 152. 3. 221. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-40549096386&partnerID=MN8TOARS . 10.1007/s00232-008-9092-x . Journal of Membrane Biology

Striatal and nigral pathology in a lentiviral rat model of Machado-Joseph disease

Alves, S.; Régulier, E.; Nascimento-Ferreira, I.; Hassig, R.; Dufour, N.; Koeppen, A.; Carvalho, A.L.; et al, Human Molecular Genetics. 2071 - 2083. 14. 17. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-46249122383&partnerID=MN8TOARS . 10.1093/hmg/ddn106 . Human Molecular Genetics

Non-viral lipid-based nanoparticles for targeted cancer systemic gene silencing

Moreira, J.N.; Santos, A.; Moura, V.; De Uma, M.C.P.; Simões, S., Journal of Nanoscience and Nanotechnology. 2187 - 2204. 5. 8. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-47149083118&partnerID=MN8TOARS . 10.1166/jnn.2008.319 . Journal of Nanoscience and Nanotechnology

Tf-lipoplexes for neuronal siRNA delivery: A promising system to mediate gene silencing in the CNS

Cardoso, A.L.C.; Simões, S.; de Almeida, L.P.; Plesnila, N.; Pedroso de Lima, M.C.; Wagner, E.; Culmsee, C., Journal of Controlled Release. 113 - 123. 2. 132. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-56349102126&partnerID=MN8TOARS . 10.1016/j.jconrel.2008.08.014 . Journal of Controlled Release

DNA pre-condensation with an amino acid-based cationic amphiphile. A viable approach for liposome-based gene delivery

Rosa, M.; Penacho, N.; Simões, S.; Lima, M.C.P.; Lindman, B.; Miguel, M.G., Molecular Membrane Biology. 23 - 34. 1. 25. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-37549013769&partnerID=MN8TOARS . 10.1080/09687680701499451 . Molecular Membrane Biology

Evaluation of the antitumoral effect mediated by IL-12 and HSV-tk genes when delivered by a novel lipid-based system

Faneca, H.; Cabrita, A.S.; Simões, S.; Pedroso de Lima, M.C., Biochimica et Biophysica Acta - Biomembranes. 1093 - 1102. 5. 1768. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34047252681&partnerID=MN8TOARS . 10.1016/j.bbamem.2006.12.017 . Biochimica et Biophysica Acta - Biomembranes

Naked DNA and lipoplexes applications in cancer gene therapy,Applications de l'ADN nu ou associé àdes liposomes en thérapie génique anticancéreuse

Bertin, S.; Neves, S.; Pedroso De Lima, M.; Pierrefite-Carle, V., Bulletin du Cancer. 243 - 252. 3. 94. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947501342&partnerID=MN8TOARS . 10.1684/bdc.2007.0218 . Bulletin du Cancer

siRNA delivery by a transferrin-associated lipid-based vector: A non-viral strategy to mediate gene silencing

Cardoso, A.L.C.; Simões, S.; de Almeida, L.P.; Pelisek, J.; Culmsee, C.; Wagner, E.; Pedroso de Lima, M.C., Journal of Gene Medicine. 170 - 183. 3. 9. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34047102911&partnerID=MN8TOARS . 10.1002/jgm.1006 . Journal of Gene Medicine

African swine fever virus p37 structural protein is localized in nuclear foci containing the viral DNA at early post-infection times

Eulálio, A.; Nunes-Correia, I.; Salas, J.; Salas, M.L.; Simões, S.; Pedroso de Lima, M.C., Virus Research. 18 - 27. 1-2. 130. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-35748981502&partnerID=MN8TOARS . 10.1016/j.virusres.2007.05.009 . Virus Research

Cellular and molecular events associated with the antitumor response induced by the cytosine deaminase/5-fluorocytosine suicide gene therapy system in a rat liver metastasis model

Bertin, S.; Neves, S.; Gavelli, A.; Baqué, P.; Brossette, N.; Simões, S.; Pedroso De Lima, M.C.; Pierrefite-Carle, V., Cancer Gene Therapy. 858 - 866. 10. 14. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548606960&partnerID=MN8TOARS . 10.1038/sj.cgt.7701075 . Cancer Gene Therapy

Interaction of S4<inf>13</inf>-PV cell penetrating peptide with model membranes: Relevance to peptide translocation across biological membranes

Mano, M.; Henriques, A.; Paiva, A.; Prieto, M.; Gavilanes, F.; Simões, S.; Pedroso de Lima, M.C., Journal of Peptide Science. 301 - 313. 5. 13. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34248347468&partnerID=MN8TOARS . 10.1002/psc.842 . Journal of Peptide Science

Cellular uptake of S4<inf>13</inf>-PV peptide occurs upon conformational changes induced by peptide-membrane interactions

Mano, M.; Henriques, A.; Paiva, A.; Prieto, M.; Gavilanes, F.; Simões, S.; Pedroso de Lima, M.C., Biochimica et Biophysica Acta - Biomembranes. 336 - 346. 3. 1758. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33646534241&partnerID=MN8TOARS . 10.1016/j.bbamem.2006.01.014 . Biochimica et Biophysica Acta - Biomembranes

Nuclear export of African swine fever virus p37 protein occurs through two distinct pathways and is mediated by three independent signals

Eulálio, A.; Nunes-Correia, I.; Carvalho, A.L.; Faro, C.; Citovsky, V.; Salas, J.; Salas, M.L.; Simões, S.; Pedroso De Lima, M.C., Journal of Virology. 1393 - 1404. 3. 80. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-31144441675&partnerID=MN8TOARS . 10.1128/JVI.80.3.1393-1404.2006 . Journal of Virology

Transfection of oral cancer cells mediated by transferrin-associated lipoplexes: Mechanisms of cell death induced by herpes simplex virus thymidine kinase/ganciclovir therapy

Neves, S.S.; Sarmento-Ribeiro, A.B.; Simões, S.P.; Pedroso de Lima, M.C., Biochimica et Biophysica Acta - Biomembranes. 1703 - 1712. 11. 1758. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750502013&partnerID=MN8TOARS . 10.1016/j.bbamem.2006.08.021 . Biochimica et Biophysica Acta - Biomembranes

Tf-lipoplex-mediated NGF gene transfer to the CNS: Neuronal protection and recovery in an excitotoxic model of brain injury

Girão da Cruz, M.T.; Cardoso, A.L.C.; de Almeida, L.P.; Simões, S.; Pedroso de Lima, M.C., Gene Therapy. 1242 - 1252. 16. 12. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-23944465946&partnerID=MN8TOARS . 10.1038/sj.gt.3302516 . Gene Therapy

On the mechanisms of the internalization of S4<inf>13</inf>-PV cell-penetrating peptide

Mano, M.; Teodósio, C.; Paiva, A.; Simões, S.; Pedroso De Lima, M.C., Biochemical Journal. 603 - 612. 2. 390. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-25144520907&partnerID=MN8TOARS . 10.1042/BJ20050577 . Biochemical Journal

Targeting of sterically stabilised pH-sensitive liposomes to human T-leukaemia cells

Fonseca, C.; Moreira, J.N.; Ciudad, C.J.; Pedroso De Lima, M.C.; Simões, S., European Journal of Pharmaceutics and Biopharmaceutics. 359 - 366. 2. 59. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-12344294490&partnerID=MN8TOARS . 10.1016/j.ejpb.2004.08.012 . European Journal of Pharmaceutics and Biopharmaceutics

Cationic liposomes for gene delivery

Simões, S.; Filipe, A.; Faneca, H.; Mano, M.; Penacho, N.; Düzgünes, N.; de Lima, M.P., Expert Opinion on Drug Delivery. 237 - 254. 2. 2. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-23744433700&partnerID=MN8TOARS . 10.1517/17425247.2.2.237 . Expert Opinion on Drug Delivery

Liposomal and viral vectors for gene therapy of the central nervous system

Pedroso de Lima, M.C.; Girão da Cruz, M.T.; Cardoso, A.L.C.; Simões, S.; Pereira de Almeida, L., Current Drug Targets: CNS and Neurological Disorders. 453 - 465. 4. 4. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-23144438160&partnerID=MN8TOARS . 10.2174/1568007054546144 . Current Drug Targets: CNS and Neurological Disorders

Cytotoxic activity of metal complexes of biogenic polyamines: Polynuclear platinum(II) chelates

Teixeira, L.J.; Seabra, M.; Reis, E.; Da Cruz, M.T.G.; De Lima, M.C.P.; Pereira, E.; Miranda, M.A.; Marques, M.P.M., Journal of Medicinal Chemistry. 2917 - 2925. 11. 47. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-2542477134&partnerID=MN8TOARS . 10.1021/jm0311238 . Journal of Medicinal Chemistry

Two African swine fever virus proteins derived from a common precursor exhibit different nucleocytoplasmic transport activities

Eulálio, A.; Nunes-Correia, I.; Carvalho, A.L.; Faro, C.; Citovsky, V.; Simões, S.; De Lima, M.C.P., Journal of Virology. 9731 - 9739. 18. 78. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-4444281591&partnerID=MN8TOARS . 10.1128/JVI.78.18.9731-9739.2004 . Journal of Virology

Electrochemical sensing of the behaviour of oligonucleotide lipoplexes at charged interfaces

Piedade, J.A.P.; Mano, M.; Pedroso De Lima, M.C.; Oretskaya, T.S.; Oliveira-Brett, A.M., Biosensors and Bioelectronics. 975 - 984. 5. 20. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-7644240649&partnerID=MN8TOARS . 10.1016/j.bios.2004.06.014 . Biosensors and Bioelectronics

Improving lipoplex-mediated gene transfer into C6 glioma cells and primary neurons

Girão Da Cruz, M.T.; Simões, S.; Pedroso De Lima, M.C., Experimental Neurology. 65 - 75. 1. 187. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-1842764711&partnerID=MN8TOARS . 10.1016/j.expneurol.2003.12.013 . Experimental Neurology

On the formulation of pH-sensitive liposomes with long circulation times

Simões, S.; Nuno Moreira, J.; Fonseca, C.; Düzgünes, N.; Pedroso De Lima, M.C., Advanced Drug Delivery Reviews. 947 - 965. 7. 56. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-1942534972&partnerID=MN8TOARS . 10.1016/j.addr.2003.10.038 . Advanced Drug Delivery Reviews

The role of target membrane sialic acid residues in the fusion activity of the influenza virus: The effect of two types of ganglioside on the kinetics of membrane merging

Ramalho-Santos, J.; Pedroso De Lima, M.C., Cellular and Molecular Biology Letters. 337 - 351. 2. 9. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-3142546892&partnerID=MN8TOARS . Cellular and Molecular Biology Letters

Voltammetric behaviour of oligonucleotide lipoplexes adsorbed onto glassy carbon electrodes

Piedade, J.A.P.; Mano, M.; Pedroso de Lima, M.C.; Oretskaya, T.S.; Oliveira-Brett, A.M., Journal of Electroanalytical Chemistry. 25 - 34. 1-2. 564. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-1342285697&partnerID=MN8TOARS . 10.1016/j.jelechem.2003.10.008 . Journal of Electroanalytical Chemistry

Association of albumin or protamine to lipoplexes: Enhancement of transfection and resistance to serum

Faneca, H.; Simões, S.; Pedroso de Lima, M.C., Journal of Gene Medicine. 681 - 692. 6. 6. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-13644260769&partnerID=MN8TOARS . 10.1002/jgm.550 . Journal of Gene Medicine

Caveolae as an additional route for influenza virus endocytosis in MDCK cells

Nunes-Correia, I.; Eulálio, A.; Nir, S.; Pedroso De Lima, M.C., Cellular and Molecular Biology Letters. 47 - 60. 1. 9. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-2342439156&partnerID=MN8TOARS . Cellular and Molecular Biology Letters

Cationic liposomes for gene delivery: From biophysics to biological applications

Pedroso de Lima, M.C.; Neves, S.; Filipe, A.; Düzgünes, N.; Simões, S., Current Medicinal Chemistry. 1221 - 1231. 14. 10. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037805617&partnerID=MN8TOARS . Current Medicinal Chemistry

Cationic liposomes for gene delivery: Novel cationic lipids and enhancement by proteins and peptides

Düzgünes, N.; Tros de Ilarduya, C.; Simões, S.; Zhdanov, R.I.; Konopka, K.; Pedroso de Lima, M.C., Current Medicinal Chemistry. 1213 - 1220. 14. 10. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-18744426403&partnerID=MN8TOARS . Current Medicinal Chemistry

Kinetics of influenza virus fusion with the endosomal and plasma membranes of cultured cells. Effect of temperature

Nunes-Correia, I.; Nir, S.; Pedroso De Lima, M.C., Journal of Membrane Biology. 21 - 26. 1. 195. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0141540481&partnerID=MN8TOARS . 10.1007/s00232-003-2040-x . Journal of Membrane Biology

Evaluation of lipid-based reagents to mediate intracellular gene delivery

Faneca, H.; Simões, S.; Pedroso de Lima, M.C., Biochimica et Biophysica Acta - Biomembranes. 23 - 33. SUPPL.. 1567. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037164699&partnerID=MN8TOARS . 10.1016/S0005-2736(02)00545-X . Biochimica et Biophysica Acta - Biomembranes

Fluorescent probes for monitoring virus fusion kinetics: Comparative evaluation of reliability

Nunes-Correia, I.; Eulálio, A.; Nir, S.; Düzgünes, N.; Ramalho-Santos, J.; Pedroso De Lima, M.C., Biochimica et Biophysica Acta - Biomembranes. 65 - 75. 1. 1561. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037133738&partnerID=MN8TOARS . 10.1016/S0005-2736(01)00457-6 . Biochimica et Biophysica Acta - Biomembranes

Protein-associated lipoplexes: Novel strategies to enhance gene delivery mediated by lipid-based particles

Simões, S.; Fonseca, C.; Faneca, H.; Düzgünes, N.; Pedroso de Lima, M.C., S.T.P. Pharma Sciences. 339 - 344. 6. 12. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036855226&partnerID=MN8TOARS . S.T.P. Pharma Sciences

Cytotoxic effects of metal complexes of biogenic polyamines. I. Platinum(II) spermidine compounds: Prediction of their antitumour activity

Marques, M.P.M.; Girão, T.; Pedroso De Lima, M.C.; Gameiro, A.; Pereira, E.; Garcia, P., Biochimica et Biophysica Acta - Molecular Cell Research. 63 - 70. 1. 1589. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037070098&partnerID=MN8TOARS . 10.1016/S0167-4889(01)00186-0 . Biochimica et Biophysica Acta - Molecular Cell Research

Cationic lipid-DNA complexes in gene delivery: From biophysics to biological applications

Pedroso De Lima, M.C.; Simões, S.; Pires, P.; Faneca, H.; Düzgünes, N., Advanced Drug Delivery Reviews. 277 - 294. 2-3. 47. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035946624&partnerID=MN8TOARS . 10.1016/S0169-409X(01)00110-7 . Advanced Drug Delivery Reviews

Delivery of novel macromolecular drugs against HIV-1

Düzgünes, N.; Simões, S.; Konopka, K.; Rossi, J.J.; Pedroso De Lima, M.C., Expert Opinion on Biological Therapy. 949 - 970. 6. 1. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035514271&partnerID=MN8TOARS . 10.1517/14712598.1.6.949 . Expert Opinion on Biological Therapy

Enhanced inhibition of HIV-1 replication in macrophages by antisense oligonucleotides, ribozymes and acyclic nucleoside phosphonate analogs delivered in pH-sensitive liposomes

Düzgünes, N.; Simões, S.; Slepushkin, V.; Pretzer, E.; Rossi, J.J.; De Clercq, E.; Antao, V.P.; Collins, M.L.; Pedroso de Lima, M.C., Nucleosides, Nucleotides and Nucleic Acids. 515 - 523. 4-7. 20. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034844548&partnerID=MN8TOARS . 10.1081/NCN-100002327 . Nucleosides, Nucleotides and Nucleic Acids

Fusion and infection of influenza and sendai viruses as modulated by dextran sulfate: A comparative study

Ramalho-Santos, J.; Pedroso De Lima, M.C., Bioscience Reports. 293 - 304. 3. 21. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035721635&partnerID=MN8TOARS . 10.1023/A:1013282015121 . Bioscience Reports

Kinetic analysis of the initial steps involved in lipoplex-cell interactions: Effect of various factors that influence transfection activity

Girão Da Cruz, M.Teresa; Simões, S.; Pires, P.P.C.; Nir, S.; Pedroso De Lima, M.C., Biochimica et Biophysica Acta - Biomembranes. 136 - 151. 1-2. 1510. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035830655&partnerID=MN8TOARS . 10.1016/S0005-2736(00)00342-4 . Biochimica et Biophysica Acta - Biomembranes

On the mechanisms of internalization and intracellular delivery mediated by pH-sensitive liposomes

Simões, Sérgio; Slepushkin, Vladimir; Düzgünes, Nejat; Pedroso de Lima, Maria C., Biochimica et Biophysica Acta (BBA) - Biomembranes. 23 - 37. 1. 1515. 2001. http://dx.doi.org/10.1016/s0005-2736(01)00389-3 . 10.1016/s0005-2736(01)00389-3 . Biochimica et Biophysica Acta (BBA) - Biomembranes

Human serum albumin enhances DNA transfection by lipoplexes and confers resistance to inhibition by serum

Simões, S.; Slepushkin, V.; Pires, P.; Gaspar, R.; Pedroso De Lima, M.C.; Düzgünes, N., Biochimica et Biophysica Acta - Biomembranes. 459 - 469. 2. 1463. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0342680042&partnerID=MN8TOARS . 10.1016/S0005-2736(99)00238-2 . Biochimica et Biophysica Acta - Biomembranes

The saposin-like domain of the plant aspartic proteinase precursor is a potent inducer of vesicle leakage

Egas, C.; Lavoura, N.; Resende, R.; Brito, R.M.M.; Pires, E.; Pedroso De Lima, M.C.; Faro, C., Journal of Biological Chemistry. 38190 - 38196. 49. 275. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034623993&partnerID=MN8TOARS . 10.1074/jbc.M006093200 . Journal of Biological Chemistry

Interaction of cationic liposomes and their DNA complexes with monocytic leukemia cells

Pires, P.; Simões, S.; Nir, S.; Gaspar, R.; Düzgünes, N.; Pedroso De Lima, M.C., Biochimica et Biophysica Acta - Biomembranes. 71 - 84. 1. 1418. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0344334068&partnerID=MN8TOARS . 10.1016/S0005-2736(99)00023-1 . Biochimica et Biophysica Acta - Biomembranes

Gene delivery mediated by cationic liposomes: From biophysical aspects to enhancement of transfection

Pedroso De Lima, M.C.; Simões, S.; Pires, P.; Gaspar, R.; Slepushkin, V.; Düzgünes, N., Molecular Membrane Biology. 103 - 109. 1. 16. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0345059269&partnerID=MN8TOARS . Molecular Membrane Biology

Cationic liposomes as gene transfer vectors: Barriers to successful application in gene therapy

Simões, S.; Pires, P.; Düzgünes, N.; Pedroso De Lima, M.C., Current Opinion in Molecular Therapeutics. 147 - 157. 2. 1. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037856537&partnerID=MN8TOARS . Current Opinion in Molecular Therapeutics

Successful transfection of lymphocytes by ternary lipoplexes

Simões, S.; Slepushkin, V.; Gaspar, R.; Pedroso De Lima, M.C.; Düzgünes, N., Bioscience Reports. 601 - 609. 6. 19. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033513298&partnerID=MN8TOARS . Bioscience Reports

Role of a transbilayer pH gradient in the membrane fusion activity of the influenza virus hemagglutinin: Use of the R18 assay to monitor membrane merging

Ramalho-Santos, J.; Pedroso De Lima, M.C., Biological Procedures Online. 107 - 113. 3. 1. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750619807&partnerID=MN8TOARS . Biological Procedures Online

Transfection of human macrophages by lipoplexes via the combined use of transferrin and pH-sensitive peptides

Simões, S.; Slepushkin, V.; Pretzer, E.; Dazin, P.; Gaspar, R.; Pedroso De Lima, M.C.; Düzgünes, N., Journal of Leukocyte Biology. 270 - 279. 2. 65. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033028724&partnerID=MN8TOARS . Journal of Leukocyte Biology

Liposome-mediated delivery of antiviral agents to human immunodeficiency virus-infected cells

Düzgünes, N.; Pretzer, E.; Simões, S.; Slepushkin, V.; Konopka, K.; Flasher, D.; Pedroso De Lima, M.C., Molecular Membrane Biology. 111 - 118. 1. 16. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032899408&partnerID=MN8TOARS . Molecular Membrane Biology

Interactions of influenza virus with cultured cells: Detailed kinetic modeling of binding and endocytosis

Nunes-Correia, I.; Ramalho-Santos, J.; Nir, S.; Pedroso De Lima, M.C., Biochemistry. 1095 - 1101. 3. 38. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033579938&partnerID=MN8TOARS . 10.1021/bi9812524 . Biochemistry

Mechanisms of gene transfer mediated by lipoplexes associated with targeting ligands or pH-sensitive peptides

Simões, S.; Slepushkin, V.; Pires, P.; Gaspar, R.; Pedroso De Lima, M.C.; Düzgünes, N., Gene Therapy. 1798 - 1807. 11. 6. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0342265531&partnerID=MN8TOARS . 10.1038/sj.gt.3301015 . Gene Therapy

Gene delivery by negatively charged ternary complexes of DNA, cationic liposomes and transferrin or fusigenic peptides

Simões, S.; Slepushkin, V.; Caspar, R.; Pedroso de Lima, M.C.; Düzgünes, N., Gene Therapy. 955 - 964. 7. 5. 1998. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031825183&partnerID=MN8TOARS . Gene Therapy

Sendai virus fusion activity as modulated by target membrane components

Nunes-Correia, I.; Ramalho-Santos, J.; Pedroso De Lima, M.C., Bioscience Reports. 59 - 68. 2. 18. 1998. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031727161&partnerID=MN8TOARS . 10.1023/A:1020180109275 . Bioscience Reports

Cholesterol affects African swine fever virus infection

Bernardes, C.; António, A.; Pedroso De Lima, M.C.; Valdeira, M.L., Biochimica et Biophysica Acta - Lipids and Lipid Metabolism. 19 - 25. 1. 1393. 1998. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032584552&partnerID=MN8TOARS . 10.1016/S0005-2760(98)00051-4 . Biochimica et Biophysica Acta - Lipids and Lipid Metabolism

The influenza virus hemagglutinin: A model protein in the study of membrane fusion

Ramalho-Santos, J.; De Lima, M.C.P., Biochimica et Biophysica Acta - Reviews on Biomembranes. 147 - 154. 1. 1376. 1998. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032578032&partnerID=MN8TOARS . 10.1016/S0304-4157(98)00002-1 . Biochimica et Biophysica Acta - Reviews on Biomembranes

Sterically stabilized pH-sensitive liposomes. Intracellular delivery of aqueous contents and prolonged circulation in vivo

Slepushkin, V.A.; Simões, S.; Dazin, P.; Newman, M.S.; Guo, L.S.; De Lima, M.C.P.; Düzgünes, N., Journal of Biological Chemistry. 2382 - 2388. 4. 272. 1997. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031032815&partnerID=MN8TOARS . 10.1074/jbc.272.4.2382 . published Journal of Biological Chemistry

Interaction of cationic liposomes with cells: Effect of several factors on liposome-cell fusion

Fires, P.; Simos, S.; Caspar, R.; Nir, S.; Dzgnes, N.; Lima, M.C., FASEB Journal. 9. 11. 1997. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750172630&partnerID=MN8TOARS . FASEB Journal

The influenza virus hemagglutinin: a model protein in the study of membrane fusion

Ramalho-Santos, J.; Almeida, M.T.; De Pedroso Lima, M.C., FASEB Journal. 9. 11. 1997. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750094182&partnerID=MN8TOARS . FASEB Journal

Evidence that synaptobrevin is involved in fusion between synaptic vesicles and synaptic plasma membrane vesicles

Almeida, M.T.; Ramalho-Santos, J.; Oliveira, C.R.; Pedroso De Lima, M.C., Biochemical and Biophysical Research Communications. 184 - 188. 1. 236. 1997. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031561140&partnerID=MN8TOARS . 10.1006/bbrc.1997.6928 . Biochemical and Biophysical Research Communications

Fusion activity of the influenza virus hemagglutinin does not require a transbilayer pH gradient

Ramalho-Santos, J.; Pedroso De Lima, M.C., Biochimica et Biophysica Acta - Biomembranes. 194 - 198. 2. 1330. 1997. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030778514&partnerID=MN8TOARS . 10.1016/S0005-2736(97)00166-1 . Biochimica et Biophysica Acta - Biomembranes

Enhancement of cationic liposome-mediated gene delivery by transferrin and fusogenic peptides

Simoes, S.; Slepushkin, V.; Gaspar, R.; Pedroso de Lima, M.C.; Duzgunes, N., Proceedings of the Controlled Release Society. 659 - 660. 24. 1997. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030800943&partnerID=MN8TOARS . Proceedings of the Controlled Release Society

Partial fusion activity of influenza virus toward liposomes and erythrocyte ghosts is distinct from viral inactivation

Ramalho-Santos, J.; De Pedroso Lima, M.C.; Nir, S., Journal of Biological Chemistry. 23902 - 23906. 39. 271. 1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029842067&partnerID=MN8TOARS . 10.1074/jbc.271.39.23902 . Journal of Biological Chemistry

Intracellular Ca<sup>2+</sup> homeostasis in human leukemic T-lymphocytes is affected by anticancer drugs: Implications for the regulation of leukemic cell growth

Da Silva, C.P.; De Oliveira, C.R.; De Lima, M.C.P., Journal of Experimental and Clinical Cancer Research. 129 - 138. 2. 15. 1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029816963&partnerID=MN8TOARS . Journal of Experimental and Clinical Cancer Research

Apoptosis as a mechanism of cell death induced by different chemotherapeutic drugs in human leukemic T-lymphocytes

Da Silva, C.P.; De Oliveira, C.R.; De Lima, M.D.C.P., Biochemical Pharmacology. 1331 - 1340. 10. 51. 1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029947269&partnerID=MN8TOARS . 10.1016/0006-2952(96)00041-X . Biochemical Pharmacology

Molecular mechanisms of chromium toxicity oxidation of hemoglobin

Alpoim, M.C.; Geraldes, C.F.; Oliveira, C.R.; Lima, M.C., Biochemical Society Transactions. 2. 23. 1995. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029010431&partnerID=MN8TOARS . Biochemical Society Transactions

The Use of Microcarrier Beads in Ion Transport NMR Studies of Perfused Cells

Zachariah, C.; Defreitas, D.M.; Castro, M.M.C.A.; Geraldes, C.F.G.C.; Lima, M.C.P.; Oliveira, C.R., Journal of Magnetic Resonance, Series B. 81 - 85. 1. 108. 1995. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029336712&partnerID=MN8TOARS . 10.1006/jmrb.1995.1106 . Journal of Magnetic Resonance, Series B

Fusion activity of African swine fever virus towards target membranes: Lipid dependence and effect of dehydrating agents

Bernardes, C.; Valdeira, M.L.; Ramalho-Santos, J.; De Lima, M.C.P., Biochemistry and Molecular Biology International. 481 - 488. 3. 37. 1995. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029555561&partnerID=MN8TOARS . Biochemistry and Molecular Biology International

Target cell membrane sialic acid modulates both binding and fusion activity of influenza virus

Pedroso de Lima, M.C.; Ramalho-Santos, J.; Flasher, D.; Slepushkin, V.A.; Nir, S.; Düzgunes, N., BBA - Biomembranes. 323 - 330. 2. 1236. 1995. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029026187&partnerID=MN8TOARS . 10.1016/0005-2736(95)00067-D . BBA - Biomembranes

Effect of myosin phosphorylation on actomyosin ATPase activity: a flow microcalorimetric study

Aureliano, M.; Pedroso, M.C.; De Lima; Carvalho, A.P.; Pires, E.M.V., Thermochimica Acta. 59 - 66. C. 258. 1995. http://www.scopus.com/inward/record.url?eid=2-s2.0-4243321608&partnerID=MN8TOARS . 10.1016/0040-6031(94)02192-Q . Thermochimica Acta

Fusion of Sendai virus with model membranes as affected by dehydrating agents and pH: Correlation between viral envelope hydrophobicity and fusion activity

Ramalho-Santos, J.; Negrao, R.; Da Conceicao Pedroso de Lima, M., Biochemistry and Molecular Biology International. 1121 - 1127. 6. 32. 1994. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028352917&partnerID=MN8TOARS . Biochemistry and Molecular Biology International

Role of hydrophobic interactions in the fusion activity of influenza and sendai viruses towards model membranes

Ramalho-Santos, J.; Negrão, R.; Lima, M.d.C.P.d., Bioscience Reports. 15 - 24. 1. 14. 1994. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028243606&partnerID=MN8TOARS . 10.1007/BF01901634 . Bioscience Reports

In vitro assay of the effects of anticancer drugs on leukemic T-cells by flow microcalorimetry

da Silva, C.P.; de Oliveira, C.R.; de Lima, M.d.C.P., International Journal of Pharmaceutics. 25 - 30. 1. 111. 1994. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028067072&partnerID=MN8TOARS . 10.1016/0378-5173(94)90398-0 . International Journal of Pharmaceutics

Parameters affecting fusion between liposomes and synaptosomes. Role of proteins, lipid peroxidation, pH and temperature

Almeida, M.T.; Ramalho-Santos, J.; Oliveira, C.R.; Pedroso de Lima, M.C., The Journal of Membrane Biology. 217 - 222. 2. 142. 1994. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027993101&partnerID=MN8TOARS . 10.1007/BF00234943 . The Journal of Membrane Biology

A common mechanism for influenza virus fusion activity and inactivation

Ramalho-Santos, J.; Nir, S.; Düzgünes, N.; De Carvalho, A.P.; De Lima, M.D.C.P., Biochemistry. 2771 - 2779. 11. 32. 1993. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027417786&partnerID=MN8TOARS . Biochemistry

Partition of Dopamine Antagonists into Synthetic Lipid Bilayers: the Effect of Membrane Structure and Composition

SARMENTO, A.B.; DE LIMA, M.C.P.; OLIVEJRA, C.R., Journal of Pharmacy and Pharmacology. 601 - 605. 7. 45. 1993. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027313440&partnerID=MN8TOARS . 10.1111/j.2042-7158.1993.tb05660.x . Journal of Pharmacy and Pharmacology

Prediction of the cytotoxic effects of methotrexate on human T-lymphoblastic leukemia cells

Brandao, F.O.; Silva, C.P.; De Lima, M.C.P.; Oliveira, C.R., Journal of Experimental and Clinical Cancer Research. 51 - 62. 1. 11. 1992. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026778561&partnerID=MN8TOARS . Journal of Experimental and Clinical Cancer Research

Interaction of clathrin with large unilamellar phospholipid vesicles at neutral pH. Lipid dependence and protein penetration

Seppen, J.; Ramalho-Santos, J.; de Carvalho, A.P.; ter Beest, M.; Kok, J.W.; Pedroso de Lima, M.C.; Hoekstra, D., BBA - Biomembranes. 209 - 215. 1. 1106. 1992. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026587918&partnerID=MN8TOARS . 10.1016/0005-2736(92)90240-M . BBA - Biomembranes

Kinetic modeling of Sendai virus fusion with PC-12 cells: Effect of pH and temperature on fusion and viral inactivation

PEDROSO DE LIMA, M.d.C.; RAMALHO-SANTOS, J.; MARTINS, M.d.F.; PATO DE CARVALHO, A.; BAIROS, V.; NIR, S., European Journal of Biochemistry. 181 - 186. 1. 205. 1992. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026611884&partnerID=MN8TOARS . 10.1111/j.1432-1033.1992.tb16766.x . European Journal of Biochemistry

Fusion activity and inactivation of influenza virus: Kinetics of low pH-induced fusion with cultured cells

Duzgunes, N.; Pedroso de Lima, M.C.; Stamatatos, L.; Flasher, D.; Alford, D.; Friend, D.S.; Nir, S., Journal of General Virology. 27 - 37. 1. 73. 1992. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026504652&partnerID=MN8TOARS . Journal of General Virology

Application of flow microcalorimetry to the study of dehydrofolate reductase activities in crude tissue homogenates

Pereira da Silva, C.M.; Pedroso de Lima, M.C., Journal of Thermal Analysis. 821 - 833. 4. 38. 1992. http://www.scopus.com/inward/record.url?eid=2-s2.0-34249838370&partnerID=MN8TOARS . 10.1007/BF01979414 . Journal of Thermal Analysis

Fusion of Sendai virus with human HL-60 and CEM cells: different kinetics of fusion for two isolates

Pedroso de Lima, M.C.; Nir, S.; Flasher, D.; Klappe, K.; Hoekstra, D.; Düzgünes, N., BBA - Biomembranes. 446 - 454. 2. 1070. 1991. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025933996&partnerID=MN8TOARS . 10.1016/0005-2736(91)90085-M . BBA - Biomembranes

A flow microcalorimetric study of the inhibition of acetylcholinesterase by catecholamine derivatives

Silva, C.M.P.; De Lima, M.C.P.; Oliveira, C.R.; Carvlho, A.P., Thermochimica Acta. 221 - 230. C. 179. 1991. http://www.scopus.com/inward/record.url?eid=2-s2.0-0347785235&partnerID=MN8TOARS . 10.1016/0040-6031(91)80351-I . Thermochimica Acta

Fusion of enveloped viruses with cells and liposomes

Shlomo Nir; Nejat Düzgünes; Maria C. Pedroso De Lima; Dick Hoekstra, Cell Biophysics. 181 - 201. 2. 17. 1990. https://doi.org/10.1007%2Fbf02990496 . 10.1007/bf02990496 . Cell Biophysics

Fusion of enveloped viruses with cells and liposomes - Activity and inactivation

Nir, S.; Düzgünes, N.; Pedroso De Lima, M.C.; Hoekstra, D., Cell Biophysics. 181 - 201. 2. 17. 1990. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025641298&partnerID=MN8TOARS . 10.1007/BF02990496 . Cell Biophysics

Interaction of antimycobacterial and anti-pneumocystis drugs with phospholipid membranes

Pedroso de Lima, M.C.; Chiche, B.H.; Debs, R.J.; Düzgünes, N., Chemistry and Physics of Lipids. 361 - 371. 4. 53. 1990. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025266029&partnerID=MN8TOARS . 10.1016/0009-3084(90)90034-O . Chemistry and Physics of Lipids

Partition of ca<sup>2+</sup> antagonists in brain plasma membranes

Carvalho, C.M.; Oliveira, C.R.; Lima, M.P.; Leysen, J.E.; Carvalho, A.P., Biochemical Pharmacology. 2121 - 2127. 13. 38. 1989. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024475173&partnerID=MN8TOARS . 10.1016/0006-2952(89)90066-X . Biochemical Pharmacology

Partition coefficients of dopamine antagonists in brain membranes and liposomes

Oliveira, C.R.; Lima, M.C.P.; Carvalho, C.A.M.; Leysen, J.E.; Carvalho, A.P., Biochemical Pharmacology. 2113 - 2120. 13. 38. 1989. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024340655&partnerID=MN8TOARS . 10.1016/0006-2952(89)90065-8 . Biochemical Pharmacology

Cholesterol affects divalent cation-induced fusion and isothermal phase transitions of phospholipid membranes

Shavnin, S.A.; Pedroso de Lima, M.C.; Fedor, J.; Wood, P.; Bentz, J.; Düzgünes, N., BBA - Biomembranes. 405 - 416. 2. 946. 1988. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024262811&partnerID=MN8TOARS . 10.1016/0005-2736(88)90416-6 . BBA - Biomembranes

Quantitative structure-activity relationships: a group additivity scheme for biological response of E. coli to the action of o-, m- and p-alkoxyphenol

Beezer, A.E.; Gooch, C.A.; Hunter, W.H.; Lima, M.C.P.; Smith, B.V., International Journal of Pharmaceutics. 251 - 254. 1-3. 38. 1987. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023628827&partnerID=MN8TOARS . 10.1016/0378-5173(87)90122-0 . International Journal of Pharmaceutics

Solution thermodynamics for o-alkoxyphenols in water and in water-alcohol systems

Beezer, A.E.; Lima, M.C.P.; Fox, G.G.; Hunter, W.H.; Smith, B.V., Thermochimica Acta. 329 - 335. C. 116. 1987. http://www.scopus.com/inward/record.url?eid=2-s2.0-39349096788&partnerID=MN8TOARS . 10.1016/0040-6031(87)88193-5 . Thermochimica Acta

Microcalorimetric measurement of the enthalpies of transfer of a series of ortho- and para-alkoxyphenols from water to octan-1-ol and from isotonic solution to Escherichia coli cells

Beezer, A.E.; Lima, M.C.P.; Fox, G.G.; Arriaga, P.; Hunter, W.H.; Smith, B.V., Journal of the Chemical Society, Faraday Transactions 1: Physical Chemistry in Condensed Phases. 2705 - 2707. 9. 83. 1987. http://www.scopus.com/inward/record.url?eid=2-s2.0-0040404893&partnerID=MN8TOARS . 10.1039/F19878302705 . Journal of the Chemical Society, Faraday Transactions 1: Physical Chemistry in Condensed Phases

Electrical conductivity, viscosity, and density of a two-component ionic system at its critical point

Schreiber, D.R.; De Lima, M.C.P.; Pitzer, K.S., Journal of Physical Chemistry. 4087 - 4091. 15. 91. 1987. http://www.scopus.com/inward/record.url?eid=2-s2.0-0001151523&partnerID=MN8TOARS . Journal of Physical Chemistry

Solution thermodynamics for alkoxy phenols in alcohol and in water-alcohol systems

Beezer, A.E.; Volpe, P.L.O.; Lima, M.C.P.; Hunter, W.H., Journal of Solution Chemistry. 341 - 348. 4. 15. 1986. http://www.scopus.com/inward/record.url?eid=2-s2.0-34250123191&partnerID=MN8TOARS . 10.1007/BF00648888 . Journal of Solution Chemistry

Critical point and phase separation for an ionic system

Pitzer, K.S.; De Lima, M.C.P.; Schreiber, D.R., Journal of Physical Chemistry. 1854 - 1855. 10. 89. 1985. http://www.scopus.com/inward/record.url?eid=2-s2.0-0039672088&partnerID=MN8TOARS . Journal of Physical Chemistry

Thermodynamics of saturated electrolyte mixtures of NaCl with Na<inf>2</inf>SO<inf>4</inf> and with MgCl<inf>2</inf>

de Lima, M.C.P.; Pitzer, K.S., Journal of Solution Chemistry. 187 - 199. 3. 12. 1983. http://www.scopus.com/inward/record.url?eid=2-s2.0-33847144669&partnerID=MN8TOARS . 10.1007/BF00648056 . Journal of Solution Chemistry

Thermodynamics of saturated aqueous solutions including mixtures of NaCl, KCl, and CsCl

de Lima, M.C.P.; Pitzer, K.S., Journal of Solution Chemistry. 171 - 185. 3. 12. 1983. http://www.scopus.com/inward/record.url?eid=2-s2.0-0001071681&partnerID=MN8TOARS . 10.1007/BF00648055 . Journal of Solution Chemistry

An investigation of non-faradaic electrocatalysis

Freund, P.L.; Conceiçâo, M.; Lima, P.; Spiro, M., Journal of Electroanalytical Chemistry. 241 - 252. 2. 133. 1982. http://www.scopus.com/inward/record.url?eid=2-s2.0-49049131731&partnerID=MN8TOARS . 10.1016/0368-1874(82)85141-1 . Journal of Electroanalytical Chemistry

A high-voltage constant-current generator

Traca, A.; Lima, M.C.P., Journal of Physics E: Scientific Instruments. 387 - 388. 4. 13. 1980. http://www.scopus.com/inward/record.url?eid=2-s2.0-0019008887&partnerID=MN8TOARS . 10.1088/0022-3735/13/4/006 . Journal of Physics E: Scientific Instruments

Transference numbers of a 2:2 electrolyte: Magnesium sulphate in water at 25°C

Lima, M.C.P.; Kumarasinghe, S.; Spiro, M., Journal of the Chemical Society, Faraday Transactions 1: Physical Chemistry in Condensed Phases. 1036 - 1044. 74. 1978. http://www.scopus.com/inward/record.url?eid=2-s2.0-37049106705&partnerID=MN8TOARS . 10.1039/F19787401036 . Journal of the Chemical Society, Faraday Transactions 1: Physical Chemistry in Condensed Phases

Analysis of organic amines and acids for water

Conceição, M.; Lima, P.; Spiro, M., Analytica Chimica Acta. 429 - 431. 2. 81. 1976. http://www.scopus.com/inward/record.url?eid=2-s2.0-49549135217&partnerID=MN8TOARS . 10.1016/S0003-2670(01)82042-0 . Analytica Chimica Acta

All projects

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Information of exclusive responsibility of the researcher 21-11-2021 , from platform CIÊNCIAVITAE.

2018 - 2020

Thioredoxin Arrest to Reduce Glioblastoma: Ethylmercury and Thimerosal to target CANCER

C490709752-00081714

Researcher

Universidade de Lisboa Faculdade de Farmácia

Funders: Fundação para a Ciência e a Tecnologia

2017 - 2020

BrainHealth2020- Early Detection, Neuromodulation and Advanced Therapies to Brain Disorders

CENTRO-01-0145-FEDER-000008

Researcher

Funders: Comissão de Coordenação e Desenvolvimento Regional do Centro

2017 - 2021

Tackling Cancer Stem Cells: A Challenge and an Opportunity to Advance in Anti-Cancer Therapy

FCT-POCI-01-0145-FEDER-016390

Researcher

Funders: Fundação para a Ciência e a Tecnologia

2016/01 - 2018/12

A Lipidomic and MiRNA-Based Strategy for GlioblastomaTtreatment

A03/2016

Principal investigator

Funders: CRUP/DAAD

2013/03 - 2015/03

Combined therapeutic approach based on miRNA modulation towards glioblastoma multiforme: A novel targeted lipid-based nanosystem for systemic delivery

Provided by PTCRIS: 124488

Principal investigator

Funders: Fundação para a Ciência e a Tecnologia, I.P.

2013/03 - 2015/08

Exploring miRNA contribution to amyloid-b-metabolism: development of a novel lentiviral platform for multiple miRNA expression in Alzheimer´s disease

Provided by PTCRIS: 125208

Researcher

Funders: Fundação para a Ciência e a Tecnologia

2010/02 - 2012/02

Suicide gene therapy in cancer stem cells from solid tumors: towards a new antitumoral strategy

No reference code Proc 441.00

Principal investigator

Funders: Fundação para a Ciência e a Tecnologia

2009/07 - 2011/12

Advancing the field of drug delivery - combined targeted treatments against human breast cancer and human leukemia (The OncotargetNanoMed network)

109361

Researcher

Funders: Fundação para a Ciência e a Tecnologia, I.P.

2009 - 2011

Interaction of Lipoplexes with Cellular Membranes: a Biophysical Approach to Gene Delivery

PTDC/QUI-BIQ/103001/2008

Researcher

Funders: Fundação para a Ciência e a Tecnologia

2007/05 - 2010/12

Development of novel approaches for anti-tumor therapy based on the S4(13)-PV cell penetrating peptide to improve the intracellular delivery of therapeutic nucleic acids and proteins

Provided by PTCRIS: 65627

Principal investigator

Funders: Fundação para a Ciência e a Tecnologia, I.P.

2007/07 - 2010/12

Silencing Machado-Joseph disease: lentiviral-mediated RNA interference to ataxin-3

Provided by PTCRIS: 70384

Researcher

Funders: Fundação para a Ciência e a Tecnologia

2005/09 - 2008/02

Targeted drug delivery to tumor vasculature: a new therapy against human breast cancer.

Provided by PTCRIS: 57831

Researcher

Funders: Fundação para a Ciência e a Tecnologia

2005/09 - 2008/08

Lentiviral vectors for gene silencing in polyglutamine disorders: Ataxin-3 gene silencing by lentiviral vectors-mediated delivery of double-stranded RNAs

Provided by PTCRIS: 56055

Researcher

Funders: Fundação para a Ciência e a Tecnologia

2004/12 - 2007/11

Mechanisms of nucleo-cytoplasmic trafficking of ASFV genome and design of anti-NLS/NES backbone cyclic peptides to block viral infection

Provided by PTCRIS: 44854

Principal investigator

Funders: Fundação para a Ciência e a Tecnologia

2003 - 2006

Targeted antisense therapy: a novel approach for the treatment of human small cell lung cancer

POCTI/FCB/48487/2002

Researcher

Funders: Fundação para a Ciência e a Tecnologia

2003 - 2006

Targeted Contrast Agents for Magnetic Resonance Imaging (MRI) and Nuclear Scintigraphy

(TARCAS) POCTI/QUI/47005/2002

Researcher

Funders: Fundação para a Ciência e a Tecnologia

2003/01 - 2005/12

Mechanisms of nucleo-cytoplasmic trafficking of ASFV genome and design of anti-NLS/NES backbone cyclic peptides to prevent viral infection

Provided by PTCRIS: 42700

Principal investigator

Funders: Fundação para a Ciência e a Tecnologia

2001 - 2004

Targeting of genes and antisense oligonucleotides by novel liposome formulations: evaluation of their therapeutic efficacy in human leukaemia.

FCT/BIO/36202/99

Researcher

Funders: Fundação para a Ciência e a Tecnologia

2000 - 2002

Strategies to Enhance Gene Delivery: Overcoming the Nuclear Barrier

No reference code

Principal investigator

Funders: NATO Scientific Affairs Division

1997 - 2000

Transport and delivery of genes and oligonucleotides mediated by liposomes: Mechanisms of internalization and design of novel formulations

PRAXIS/ PCNA/P/BIO/45/ 96

Principal investigator

Funders: Fundação para a Ciência e a Tecnologia

1997/09 - 2000/09

Non-Viral Gene Transfer Vectors.

EC BIO4-CT97-2191

Principal investigator

Funders: European Commission

1993 - 1998

Mechanisms of genetic variability and immunoresistance to African Swine Fever Virus

PBIC/P/AGR/1824/93

Principal investigator

Funders: Fundação para a Ciência e a Tecnologia

1993 - 1996

Mechanisms of fusion and uncoating of African Swine Fever virus: Initial stages of viral infection

STRDA/C/AGR/191/92

Principal investigator

Funders: Fundação para a Ciência e a Tecnologia

1990 - 1994

Fusion Activity of lipid enveloped viruses

CRG.900333

Principal investigator

Funders: NATO Scientific Affairs Division

1990/09/01 - 1993/09/01

Membrane fusion : Mechanisms of viral infection and intracelular membrane fusion

PMCT/C/BIO/214/90

Principal investigator

Center for Cell Biology , University of Coimbra

1986/09 - 1987/09

Calorimetric and Thermodynamic Study of the Interaction of Calcium Channel Blockers and of Dopamine Agonists and Antagonists with Liposomes and Biological Membranes

no reference

Principal investigator

1986/09 - 1987/09

Determination of Thermodynamic Parameters in Biomembranes

no reference code

Principal investigator

Funders: Fundação Calouste Gulbenkian

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