Miranda Mele

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Researcher

Publications

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Information about journal articles, updated at 28-11-2021, from platform CIÊNCIAVITAE.

GRASP1 ubiquitination regulates AMPA receptor surface expression and synaptic activity in cultured hippocampal neurons

Mele, Miranda; De Luca, Pasqualino; Santos, Ana Rita; Vieira, Marta; Salazar, Ivan L.; Pinheiro, Paulo S.; Duarte, Carlos B., The FASEB Journal. 8. 35. 2021. http://dx.doi.org/10.1096/fj.201903061rr . 10.1096/fj.201903061rr . The FASEB Journal

Transient incubation of cultured hippocampal neurons in the absence of magnesium induces rhythmic and synchronized epileptiform-like activity

Mele, Miranda; Vieira, Ricardo; Correia, Bárbara; De Luca, Pasqualino; Duarte, Filipe V.; Pinheiro, Paulo S.; Duarte, Carlos B., Scientific Reports. 1. 11. 2021. http://dx.doi.org/10.1038/s41598-021-90486-y . 10.1038/s41598-021-90486-y . Scientific Reports

Synaptogenesis Stimulates a Proteasome-Mediated Ribosome Reduction in Axons

Costa, Rui O.; Martins, Helena; Martins, Luís F.; Cwetsch, Andrzej W.; Mele, Miranda; Pedro, Joana R.; Tomé, Diogo; et al, Cell Reports. 864 - 876.e6. 4. 28. 2019. http://dx.doi.org/10.1016/j.celrep.2019.06.080 . 10.1016/j.celrep.2019.06.080 . published Cell Reports

Alterations in GABAA-Receptor Trafficking and Synaptic Dysfunction in Brain Disorders.

Mele, M.; Costa R.O; Duarte, C.B., Frontiers in Cellular Neuroscience. 2019. http://europepmc.org/articles/PMC6416223 . 10.3389/fncel.2019.00077 . Frontiers in Cellular Neuroscience

BDNF increases synaptic NMDA receptor abundance by enhancing the local translation of Pyk2 in cultured hippocampal neurons

Pedro Afonso; Pasqualino De Luca; Rafael S. Carvalho; Luísa Cortes; Paulo Pinheiro; Barbara Oliveiros; Ramiro D. Almeida; Miranda Mele; Carlos B. Duarte, Science Signaling. eaav3577 - eaav3577. 586. 12. 2019. https://doi.org/10.1126/scisignal.aav3577 . 10.1126/scisignal.aav3577 . Science Signaling

https://bio-protocol.org/e2551

Mele, Miranda, Bio-protocol. 2017. https://bio-protocol.org/e2551 . 10.21769/BioProtoc.2551 . Bio-protocol

The RNA-Binding Protein hnRNP K Mediates the Effect of BDNF on Dendritic mRNA Metabolism and Regulates Synaptic NMDA Receptors in Hippocampal Neurons

Graciano Leal; Diogo Comprido; Pasqualino de Luca; Eduardo Morais; Luís Rodrigues; Miranda Mele; Ana R. Santos; et al, eneuro. ENEURO.0268 - 17.2017. 6. 4. 2017. https://doi.org/10.1523/ENEURO.0268-17.2017 . 10.1523/ENEURO.0268-17.2017 . eneuro

Downregulation of GABA<inf>A</inf>Receptor Recycling Mediated by HAP1 Contributes to Neuronal Death in In Vitro Brain Ischemia

Mele, M.; Aspromonte, M.C.; Duarte, C.B., Molecular Neurobiology. 45 - 57. 1. 54. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-84953293603&partnerID=MN8TOARS . 10.1007/s12035-015-9661-9 . Molecular Neurobiology

Preparation of Primary Cultures of Embryonic Rat Hippocampal and Cerebrocortical Neurons

Salazar, Ivan; Mele, Miranda; Caldeira, Margarida; Costa, Rui; Correia, Bárbara; Frisari, Simone; Duarte, Carlos, BIO-PROTOCOL. 18. 7. 2017. http://dx.doi.org/10.21769/bioprotoc.2551 . 10.21769/bioprotoc.2551 . BIO-PROTOCOL

Role of GABA<inf>A</inf>R trafficking in the plasticity of inhibitory synapses

Mele, M.; Leal, G.; Duarte, C.B., Journal of Neurochemistry. 997 - 1018. 6. 139. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84990020943&partnerID=MN8TOARS . 10.1111/jnc.13742 . Journal of Neurochemistry

Multiple domains in the C-terminus of NMDA receptor GluN2B subunit contribute to neuronal death following in vitro ischemia

Vieira, M.M.; Schmidt, J.; Ferreira, J.S.; She, K.; Oku, S.; Mele, M.; Santos, A.E.; et al, Neurobiology of Disease. 223 - 234. 89. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84959360132&partnerID=MN8TOARS . 10.1016/j.nbd.2015.11.007 . Neurobiology of Disease

Calpains and neuronal damage in the ischemic brain: The swiss knife in synaptic injury

Curcio, M.*; Salazar, I.L.*; Mele, Miranda*(Co-Firs); Canzoniero, L.M.T.; Duarte, C.B., Progress in Neurobiology. 1 - 35. 143. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84979684030&partnerID=MN8TOARS . 10.1016/j.pneurobio.2016.06.001 . Progress in Neurobiology

Erratum to “Calpains and neuronal damage in the ischemic brain: The swiss knife in synaptic injury” (Progress in Neurobiology (2016) 147 (20) (S0301008216300090) (10.1016/j.pneurobio.2016.06.001))

Curcio, M.; Salazar, I.L.; Mele, M.; Canzoniero, L.M.T.; Duarte, C.B., Progress in Neurobiology. 147. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84997683943&partnerID=MN8TOARS . 10.1016/j.pneurobio.2016.08.004 . Progress in Neurobiology

Differential role of the proteasome in the early and late phases of BDNF-induced facilitation of LTP

Santos, A.R.; Mele, M.; Vaz, S.H.; Kellermayer, B.; Grimaldi, M.; Colino-Oliveira, M.; Rombo, D.M.; et al, Journal of Neuroscience. 3319 - 3329. 8. 35. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84923356181&partnerID=MN8TOARS . 10.1523/JNEUROSCI.4521-14.2015 . Journal of Neuroscience

Gephyrin Cleavage in In Vitro Brain Ischemia Decreases GABAA Receptor Clustering and Contributes to Neuronal Death

Costa, João T.*; Mele, Miranda*(Co-Firs); Baptista, Márcio S.; Gomes, João R.; Ruscher, Karsten; Nobre, Rui J.; de Almeida, Luís Pereira; Wieloch, Tadeusz; Duarte, Carlos B., Molecular Neurobiology. 3513 - 3527. 6. 53. 2015. http://dx.doi.org/10.1007/s12035-015-9283-2 . 10.1007/s12035-015-9283-2 . Molecular Neurobiology

GABAA receptor dephosphorylation followed by internalization is coupled to neuronal death in in vitro ischemia

Mele, M.; Ribeiro, L.; Inácio, A.R.; Wieloch, T.; Duarte, C.B., Neurobiology of Disease. 220 - 232. 65. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84896313006&partnerID=MN8TOARS . 10.1016/j.nbd.2014.01.019 . Neurobiology of Disease

BDNF Regulates the Expression and Distribution of Vesicular Glutamate Transporters in Cultured Hippocampal Neurons

Melo, C.V.; Mele, M.; Curcio, M.; Comprido, D.; Silva, C.G.; Duarte, C.B., PLoS ONE. 1. 8. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872222727&partnerID=MN8TOARS . 10.1371/journal.pone.0053793 . PLoS ONE

Excitotoxic stimulation downregulates the ubiquitin-proteasome system through activation of NMDA receptors in cultured hippocampal neurons

Caldeira, M.V.; Curcio, M.; Leal, G.; Salazar, I.L.; Mele, M.; Santos, A.R.A.; Melo, C.V.; et al, Biochimica et Biophysica Acta - Molecular Basis of Disease. 263 - 274. 1. 1832. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84868560715&partnerID=MN8TOARS . 10.1016/j.bbadis.2012.10.009 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Cleavage of the vesicular glutamate transporters under excitotoxic conditions

Lobo, A.C.; Gomes, J.R.; Catarino, T.; Mele, M.; Fernandez, P.; Inácio, A.R.; Bahr, B.A.; et al, Neurobiology of Disease. 292 - 303. 3. 44. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80053269066&partnerID=MN8TOARS . 10.1016/j.nbd.2011.07.010 . Neurobiology of Disease

All projects

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Information of exclusive responsibility of the researcher 28-11-2021 , from platform CIÊNCIAVITAE.

2018/06/01 - 2021/06/30

BDNF-induced alterations in the synaptic proteome and neuronal excitability in the pilocarpine model of temporal lobel epilepsy

POCI-01-0145-FEDER-028656 PTDC

Principal investigator

CNC.IBILI

Funders: Fundação para a Ciência e a Tecnologia

2018/05/01 - 2021/05/31

Targeting the K+-Cl- cotransporter (KCC2) to maintain GABAergic neurotransmission: a novel therapeutic strategy for epilepsy’.

CENTRO-01-0145-FEDER-030659

Principal investigator

CNC.IBILI

Funders: Fundação para a Ciência e a Tecnologia

2016 - 2017

Novel cerebrospinal fluid and serum biomarkers for Multiple Sclerosis

RG-1601-07502

Post-doc

CNC.IBILI

Funders: National Multiple Sclerosis Society

2015 - 2015

New strategies to manage brain disease

CENTRO-07-ST24-FEDER-002002-MAIS CENTRO

Post-doc Fellow

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2015 - 2015

Regulation of the ubiquitin-proteasome system by BDNF at the hippocampal synapses: role in synaptic plasticity

PTDC/SAU-NMC/120144/2010

Post-doc Fellow

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2014/03/01 - 2016/02/29

Alteration in GABAA Receptor trafficking in status epilepticus

Bolsa Científica da LPCE 2019

Principal investigator

CNC.IBILI

Funders: Liga Portuguesa Contra a Epilepsia

2014/03/01 - 2016/02/29

Alteration in GABAA Receptor trafficking in status epilepticus

Bolsa Científica da LPCE 2019

Principal investigator

CNC.IBILI

Funders: Liga Portuguesa Contra a Epilepsia

2013/07 - 2015/09

Downregulation of the GABAergic synaptic transmission in brain ischemia - molecular mechanisms of GABAA receptor internalization

grant.Provided by PTCRIS: 124339

Researcher

Funders: Fundação para a Ciência e a Tecnologia

2013 -

Projecto Estratégico CNC.IBILI. CNC.IBILI Institute

UID/NEU/04539/2013

Researcher

CNC.IBILI

Funders: Fundação para a Ciência e a Tecnologia

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