Nuno Empadinhas

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Researcher

Publications

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Information about journal articles, updated at 05-12-2021, from platform CIÊNCIAVITAE.

Footprints of a microbial toxin from the gut microbiome to mesencephalic mitochondria

Esteves AR; Alarico S, Gut. 1 - 20211. 2021. http://dx.doi.org/10.1136/gutjnl-2021-326023 . 10.1136/gutjnl-2021-326023 . published Gut

The neuromicrobiology of Parkinson's disease: A unifying theory

Muñoz-Pinto MF, Ageing Research Reviews. 70. 2021. http://dx.doi.org/10.1016/j.arr.2021.101396 . 10.1016/j.arr.2021.101396 . published Ageing Research Reviews

Improved diabetic wound healing by bovine lactoferricin is associated with relevant changes in the skin immune response and microbiota

Mouritzen MV, Molecular Therapy - Methods & Clinical Development. 726 - 739. 20. 2021. https://doi.org/10.1016/j.omtm.2021.02.008 . 10.1016/j.omtm.2021.02.008 . published Molecular Therapy - Methods & Clinical Development

The Mitochondrial Ribosome: A World of Opportunities for Mitochondrial Dysfunction Toward Parkinson's Disease

Gonçalves AM, Antioxidants & Redox Signaling. 694 - 711. 8. 34. 2021. https://www.liebertpub.com/doi/10.1089/ars.2019.7997 . 10.1089/ars.2019.7997 . published Antioxidants & Redox Signaling

Microbial BMAA elicits mitochondrial dysfunction, innate immunity activation and Alzheimer's disease features in cortical neurons

Silva DF, Journal of Neuroinflammation. 332. 17. 2020. http://dx.doi.org/10.1186/s12974-020-02004-y . 10.1186/s12974-020-02004-y . published Journal of Neuroinflammation

Editorial: Interplay Between Nutrition, the Intestinal Microbiota and the Immune System

Oriá RB, Frontiers in Immunology. 11. 2020. http://dx.doi.org/10.3389/fimmu.2020.01758 . 10.3389/fimmu.2020.01758 . published Frontiers in Immunology

Stabilization of blood for long-term storage can affect antibody-based recognition of cell surface markers

Silva MB; Färnert A, Journal of Immunological Methods. 481. 2020. http://dx.doi.org/10.1016/j.jim.2020.112792 . 10.1016/j.jim.2020.112792 . published Journal of Immunological Methods

A genuine mycobacterial thermophile: Mycobacterium hassiacum growth, survival and GpgS stability at near-pasteurization temperatures

Alarico S, Microbiology. 474 - 483. 5. 166. 2020. http://dx.doi.org/10.1099/mic.0.000898 . 10.1099/mic.0.000898 . published Microbiology

Microbial BMAA and the Pathway for Parkinson's Disease Neurodegeneration

Nunes-Costa D, Frontiers in Aging Neuroscience. 12. 2020. https://doi.org/10.3389/fnagi.2020.00026 . 10.3389/fnagi.2020.00026 . published Frontiers in Aging Neuroscience

The structural characterization of a glucosylglycerate hydrolase provides insights into the molecular mechanism of mycobacterial recovery from nitrogen starvation

Cereija TB, IUCrJ. 572 - 585. 4. 6. 2019. https://doi.org/10.1107/S2052252519005372 . 10.1107/S2052252519005372 . published IUCrJ

High-Quality Draft Genome Sequences of Rare Nontuberculous Mycobacteria Isolated from Surfaces of a Hospital

Tiago I, Microbiology Resource Announcements. 21. 8. 2019. https://doi.org/10.1128/MRA.00496-19 . 10.1128/MRA.00496-19 . published Microbiology Resource Announcements

Biosynthesis of mycobacterial methylmannose polysaccharides requires a unique 1-O-methyltransferase specific for 3-O-methylated mannosides

Ripoll-Rozada J; Pereira PJB; Empadinhas N, Proceedings of the National Academy of Sciences. 201813450 - 201813450. 2019. https://www.pnas.org/content/116/3/835.long . 10.1073/pnas.1813450116 . published Proceedings of the National Academy of Sciences

Studies of antimicrobial resistance in rare mycobacteria from a nosocomial environment

Pereira SG, BMC Microbiology. 1. 19. 2019. http://dx.doi.org/10.1186/s12866-019-1428-4 . 10.1186/s12866-019-1428-4 . published BMC Microbiology

Molecular Fingerprints for a Novel Enzyme Family in Actinobacteria with Glucosamine Kinase Activity

Manso JA, mBio. 2019. https://doi.org/10.1128/mBio.00239-19 . 10.1128/mBio.00239-19 . published mBio

The Microbiome-Mitochondria Dance in Prodromal Parkinson’s Disease

Cardoso SM, Empadinhas N, Frontiers in Physiology. 9. 2018. https://www.frontiersin.org/articles/10.3389/fphys.2018.00471/full . 10.3389/fphys.2018.00471 . published Frontiers in Physiology

Production, crystallization and structure determination of a mycobacterial glucosylglycerate hydrolase

Cereija TB, Acta Crystallographica Section F Structural Biology Communications. 536 - 540. 9. 73. 2017. https://doi.org/10.1107%2Fs2053230x17012419 . 10.1107/S2053230X17012419 . published Acta Crystallographica Section F Structural Biology Communications

Hospital microbial surface colonization revealed during monitoring of Klebsiella spp., Pseudomonas aeruginosa, and non-tuberculous mycobacteria

Farias PG, Antonie van Leeuwenhoek. 863 - 876. 7. 110. 2017. http://dx.doi.org/10.1007/s10482-017-0857-z . 10.1007/s10482-017-0857-z . published Antonie van Leeuwenhoek

Microbiota of Chronic Diabetic Wounds: Ecology, Impact, and Potential for Innovative Treatment Strategies

Pereira SG, Frontiers in Microbiology. 8. 2017. https://doi.org/10.3389%2Ffmicb.2017.01791 . 10.3389/fmicb.2017.01791 . published Frontiers in Microbiology

Glucosylglycerate metabolism, bioversatility and mycobacterial survival

Nunes-Costa D, Glycobiology. 213 - 227. 27. 2016. http://dx.doi.org/10.1093/glycob/cww132 . 10.1093/glycob/cww132 . published Glycobiology

The looming tide of nontuberculous mycobacterial infections in Portugal and Brazil

Nunes-Costa D, Tuberculosis. 107 - 119. 96. 2016. http://dx.doi.org/10.1016/j.tube.2015.09.006 . 10.1016/j.tube.2015.09.006 . published Tuberculosis

Octanoylation of early intermediates of mycobacterial methylglucose lipopolysaccharides

Maranha A; Clarke AJ, Empadinhas N, Scientific Reports. 1. 5. 2015. http://dx.doi.org/10.1038/srep13610 . 10.1038/srep13610 . published Scientific Reports

Structure of mycobacterial maltokinase, the missing link in the essential GlgE-pathway

Fraga JS, Scientific Reports. 5. 2015. https://doi.org/10.1038/srep08026 . 10.1038/srep08026 . published Scientific Reports

Structure of Mycobacterium thermoresistibile GlgE defines novel conformational states that contribute to the catalytic mechanism

Mendes V, Scientific Reports. 1. 5. 2015. http://dx.doi.org/10.1038/srep17144 . 10.1038/srep17144 . published Scientific Reports

The molecular biology of mycobacterial trehalose in the quest for advanced tuberculosis therapies

Nobre A, Microbiology (United Kingdom). 1547 - 1570. PART 8. 160. 2014. https://doi.org/10.1099/mic.0.075895-0 . 10.1099/mic.0.075895-0 . published Microbiology (United Kingdom)

Autophagy in the fight against tuberculosis

Bento CF, DNA and Cell Biology. 228 - 242. 4. 34. 2014. https://doi.org/10.1089/dna.2014.2745 . 10.1089/dna.2014.2745 . published DNA and Cell Biology

Mycobacterium hassiacum recovers from nitrogen starvation with up-regulation of a novel glucosylglycerate hydrolase and depletion of the accumulated glucosylglycerate

Alarico S, Scientific Reports. 1. 4. 2014. http://dx.doi.org/10.1038/srep06766 . 10.1038/srep06766 . published Scientific Reports

A new bacterial hydrolase specific for the compatible solutes alpha-D-mannopyranosyl-(1,2)-D-glycerate and alpha-D-glucopyranosyl-(1,2)-D-glycerate

Alarico S, Enzyme and Microbial Technology. 77 - 83. 2. 52. 2013. http://dx.doi.org/10.1016/j.enzmictec.2012.10.008 . 10.1016/j.enzmictec.2012.10.008 . published Enzyme and Microbial Technology

The plant Selaginella moellendorffii possesses enzymes for synthesis and hydrolysis of the compatible solutes mannosylglycerate and glucosylglycerate

Nobre A, Planta. 891 - 901. 3. 237. 2013. https://doi.org/10.1007/s00425-012-1808-6 . 10.1007/s00425-012-1808-6 . published Planta

Genome sequence of Mycobacterium hassiacum DSM 44199, a rare source of heat-stable mycobacterial proteins

Tiago I, Journal of Bacteriology. 7010 - 7011. 24. 194. 2012. DOI: https://doi.org/10.1128/JB.01880-12 . 10.1128/JB.01880-12 . published Journal of Bacteriology

Biosynthesis of mycobacterial methylglucose lipopolysaccharides

Mendes V, Natural Product Reports. 834 - 844. 8. 29. 2012. https://doi.org/10.1039/C2NP20014G . 10.1039/c2np20014g . published Natural Product Reports

Mycobacterium tuberculosis Rv2419c, the missing glucosyl-3-phosphoglycerate phosphatase for the second step in methylglucose lipopolysaccharide biosynthesis

Mendes V, Scientific Reports. 1. 1. 2011. http://dx.doi.org/10.1038/srep00177 . 10.1038/srep00177 . published Scientific Reports

Functional and structural characterization of a novel mannosyl-3-phosphoglycerate synthase from Rubrobacter xylanophilus reveals its dual substrate specificity

Empadinhas N, Molecular Microbiology. 76 - 93. 1. 79. 2011. https://doi.org/10.1111/j.1365-2958.2010.07432.x . 10.1111/j.1365-2958.2010.07432.x . published Molecular Microbiology

Diversity, biological roles and biosynthetic pathways for sugar-glycerate containing compatible solutes in bacteria and archaea

Empadinhas N, da Costa MS, Environmental Microbiology. 2056 - 2077. 8. 13. 2011. https://doi.org/10.1111/j.1462-2920.2010.02390.x . 10.1111/j.1462-2920.2010.02390.x . published Environmental Microbiology

Two alternative pathways for the synthesis of the rare compatible solute mannosylglucosylglycerate in Petrotoga mobilis

Fernandes C, Journal of Bacteriology. 1624 - 1633. 6. 192. 2010. https://doi.org/10.1128/JB.01424-09 . 10.1128/JB.01424-09 . published Journal of Bacteriology

Biochemical characterization of the maltokinase from Mycobacterium bovis BCG

Mendes V, BMC Biochemistry. 2010. https://doi.org/10.1186/1471-2091-11-21 . 10.1186/1471-2091-11-21 . published BMC Biochemistry

Identification of the mycobacterial glucosyl-3-phosphoglycerate synthase

Empadinhas N, FEMS Microbiology Letters. 195 - 202. 2. 280. 2008. https://doi.org/10.1111/j.1574-6968.2007.01064.x . 10.1111/j.1574-6968.2007.01064.x . published FEMS Microbiology Letters

Crystallization and preliminary crystallographic analysis of mannosyl-3-phosphoglycerate synthase from Rubrobacter xylanophilus

Sá-Moura B, Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 760 - 763. 8. 64. 2008. https://doi.org/10.1107/S1744309108021490 . 10.1107/S1744309108021490 . published Acta Crystallographica Section F: Structural Biology and Crystallization Communications

To be or not to be a compatible solute: Bioversatility of mannosylglycerate and glucosylglycerate

Empadinhas N, da Costa MS, Systematic and Applied Microbiology. 159 - 168. 3. 31. 2008. https://doi.org/10.1016/j.syapm.2008.05.002 . 10.1016/j.syapm.2008.05.002 . published Systematic and Applied Microbiology

Osmoadaptation mechanisms in prokaryotes: Distribution of compatible solutes

Empadinhas N, da Costa MS, International Microbiology. 151 - 161. 3. 11. 2008. https://europepmc.org/article/med/18843593 . 10.2436/20.1501.01.55 . published International Microbiology

Mycobacterium tuberculosis glucosyl-3-phosphoglycerate synthase: Structure of a key enzyme in methylglucose lipopolysaccharide biosynthesis

Pereira PJB, PLoS ONE. 11. 3. 2008. https://doi.org/10.1371/journal.pone.0003748 . 10.1371/journal.pone.0003748 . published PLoS ONE

Molecular and physiological role of the trehalose-hydrolyzing a-glucosidase from Thermus thermophilus HB27

Alarico S, Journal of Bacteriology. 2298 - 2305. 7. 190. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-41549086172&partnerID=MN8TOARS . 10.1128/JB.01794-07 . published Journal of Bacteriology

A Unique Combination of Genetic Systems for the Synthesis of Trehalose in Rubrobacter xylanophilus: Properties of a Rare Actinobacterial TreT

Nobre A, Journal of Bacteriology. 7939 - 7946. 24. 190. 2008. http://dx.doi.org/10.1128/jb.01055-08 . 10.1128/jb.01055-08 . published Journal of Bacteriology

Bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol: Inositol-1-phosphate transferase, the key enzyme for di-myo-inositol-phosphate synthesis in several (hyper)thermophiles

Rodrigues MV, Journal of Bacteriology. 5405 - 5412. 15. 189. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34547629796&partnerID=MN8TOARS . 10.1128/JB.00465-07 . published Journal of Bacteriology

Glucosylglycerate biosynthesis in the deepest lineage of the Bacteria: Characterization of the thermophilic proteins GpgS and GpgP from Persephonella marina

Costa J, Journal of Bacteriology. 1648 - 1654. 5. 189. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947366922&partnerID=MN8TOARS . 10.1128/JB.00841-06 . published Journal of Bacteriology

Single-step pathway for synthesis of glucosylglycerate in Persephonella marina

Fernandes C, Journal of Bacteriology. 4014 - 4019. 11. 189. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34249786874&partnerID=MN8TOARS . 10.1128/JB.00075-07 . published Journal of Bacteriology

Organic solutes in Rubrobacter xylanophilus: The first example of di-myo-inositol-phosphate in a thermophile

Empadinhas N, Extremophiles. 667 - 673. 5. 11. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548303944&partnerID=MN8TOARS . 10.1007/s00792-007-0084-z . published Extremophiles

Mannosylglycerate is essential for osmotic adjustment in Thermus thermophilus strains HB27 and RQ-1

Alarico S, Extremophiles. 833 - 840. 6. 11. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-35748948644&partnerID=MN8TOARS . 10.1007/s00792-007-0106-x . published Extremophiles

Diversity and biosynthesis of compatible solutes in hyper/thermophiles

Empadinhas N, da Costa MS, International Microbiology. 199 - 206. 3. 9. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750584278&partnerID=MN8TOARS . published International Microbiology

Characterization of the biosynthetic pathway of glucosylglycerate in the archaeon Methanococcoides burtonii

Costa J, Journal of Bacteriology. 1022 - 1030. 3. 188. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-31344453995&partnerID=MN8TOARS . 10.1128/JB.188.3.1022-1030.2006 . published Journal of Bacteriology

Distribution of genes for synthesis of trehalose and mannosylglycerate in Thermus spp. and direct correlation of these genes with halotolerance

Alarico S, Applied and Environmental Microbiology. 2460 - 2466. 5. 71. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-18444382346&partnerID=MN8TOARS . 10.1128/AEM.71.5.2460-2466.2005 . published Applied and Environmental Microbiology

Meiothermus timidus sp. nov., a new slightly thermophilic yellow-pigmented species

Pires AL, FEMS Microbiology Letters. 39 - 45. 1. 245. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-15744405109&partnerID=MN8TOARS . 10.1016/j.femsle.2005.02.011 . published FEMS Microbiology Letters

Specialized Roles of the Two Pathways for the Synthesis of Mannosylglycerate in Osmoadaptation and Thermoadaptation of Rhodothermus marinus

Borges N, Journal of Biological Chemistry. 9892 - 9898. 11. 279. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-1642279326&partnerID=MN8TOARS . 10.1074/jbc.M312186200 . published Journal of Biological Chemistry

A gene from the mesophilic bacterium Dehalococcoides ethenogenes encodes a novel mannosylglycerate synthase

Empadinhas N, Journal of Bacteriology. 4075 - 4084. 13. 186. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-3042523198&partnerID=MN8TOARS . 10.1128/JB.186.13.4075-4084.2004 . published Journal of Bacteriology

The Bacterium Thermus thermophilus , Like Hyperthermophilic Archaea, Uses a Two-Step Pathway for the Synthesis of Mannosylglycerate

Empadinhas N, Applied and Environmental Microbiology. 3272 - 3279. 6. 69. 2003. http://dx.doi.org/10.1128/aem.69.6.3272-3279.2003 . 10.1128/aem.69.6.3272-3279.2003 . published Applied and Environmental Microbiology

Gamma-Proteobacteria Aquicella lusitana gen. nov., sp. nov., and Aquicella siphonis sp. nov. Infect Protozoa and Require Activated Charcoal for Growth in Laboratory Media

Santos P, Applied and Environmental Microbiology. 6533 - 6540. 11. 69. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0242573382&partnerID=MN8TOARS . 10.1128/AEM.69.11.6533-6540.2003 . published Applied and Environmental Microbiology

Rubritepida flocculans gen. nov., sp. nov., a New Slightly Thermophilic Member of the a-1 Subclass of the Proteobacteria

Alarico S, Systematic and Applied Microbiology. 198 - 206. 2. 25. 2002. http://dx.doi.org/10.1078/0723-2020-00116 . 10.1078/0723-2020-00116 . published Systematic and Applied Microbiology

Albidovulum inexpectatum gen. nov., sp. nov., a nonphotosynthetic and slightly thermophilic bacterium from a marine hot spring that is very closely related to members of the photosynthetic genus Rhodovulum

Albuquerque L, Applied and Environmental Microbiology. 4266 - 4273. 9. 68. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036729238&partnerID=MN8TOARS . 10.1128/AEM.68.9.4266-4273.2002 . published Applied and Environmental Microbiology

Pathway for the synthesis of mannosylglycerate in the hyperthermophilic archaeon Pyrococcus horikoshii: Biochemical and genetic characterization of key enzymes

Empadinhas N, Journal of Biological Chemistry. 43580 - 43588. 47. 276. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035941355&partnerID=MN8TOARS . 10.1074/jbc.M108054200 . published Journal of Biological Chemistry

Biosynthesis of mannosylglycerate in the thermophilic bacterium Rhodothermus marinus. Biochemical and genetic characterization of a mannosylglycerate synthase

Martins LO, Journal of Biological Chemistry. 35407 - 35414. 50. 274. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033544948&partnerID=MN8TOARS . 10.1074/jbc.274.50.35407 . published Journal of Biological Chemistry

All projects

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Information of exclusive responsibility of the researcher 05-12-2021 , from platform CIÊNCIAVITAE.

2022 - 2025

Nontuberculous mycobacteria from drinking water: beyond the lung disease epidemic (PI)

PTDC/BIA-MIC/0122/2021

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2022 - 2023

Microbiome-miRNAs axis in Parkinson's disease: involvement of mitochondrial mediated inflammatory response

EXPL/MED-NEU/1515/2021

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2021 - 2025

CIBB - Center for Innovative Biomedicine and Biotechnology - Associate Laboratory (Institutional)

LA/P/0058/2020

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2021 - 2025

DYNABrain - Dynamic Brain Function: Towards the Understanding and Treatment of Brain Disorders (ERA Chairs - Institutional)

H2020-WIDESPREAD-2018-2020-6, ID: 952422

Other

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: European Commission

2021 - 2024

STOPD - The Gut-Immune-Brain Axis in Parkinson disease (Co-PI)

PTDC/MED-NEU/3644/2020

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2020 - 2023

CIBB - Center for Innovative Biomedicine and Biotechnology (Institutional)

UIDB/04539/2020 and UIDP/04539/2020

Researcher

Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia (CIBB)

Funders: Fundação para a Ciência e a Tecnologia

2020 - 2021

Sustainable and dual function polymeric edible films: a probiotic and antioxidant delivery food packaging system

Prémio Projetos Semente de I&D "Era pós-COVID 19: uma sociedade mais sustentável, resiliente e justa

Researcher

Universidade de Coimbra

Funders: Universidade de Coimbra/Santander

2018 - 2022

STERILAEROGEL - Green method to prepare sterilized biopolymers based aerogel

POCI-01-0145-FEDER-032625

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular; Universidade de Coimbra Departamento de Engenharia Quimica

Funders: Fundação para a Ciência e a Tecnologia

2018 - 2018

Prevalência de micobactérias não-tuberculosas em ambiente doméstico (Co-PI)

Prémio Thomé Villar/Boehringer Ingelheim 2017

Principal investigator

Universidade do Porto Instituto de Saúde Pública; Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Sociedade Portuguesa de Pneumologia; Boehringer Ingelheim Portugal

2018 - 2021

POLYREP - An intriguing mycobacterial polysaccharide: recycling, replication and beyond (PI)

PTDC/BTM-TEC/29221/2017

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2018 - 2018

The role of microbial metabolites in Parkinson's Disease

PEPITA Award 2018

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Faculdade de Medicina, Universidade de Coimbra & Banco Santander

2017 - 2021

HealthyAging2020 (WP9 - Deciphering microbiome signatures in chronic diseases for early diagnosis and modulation therapies) (Institutional-HR)

CENTRO-01-0145-FEDER-000012-N2323

Researcher

CNC.IBILI; Universidade de Coimbra

Funders: European Regional Development Fund; Comissão de Coordenação e Desenvolvimento Regional do Centro

2017 - 2020

The toxinogenic gut microbiome in sporadic Parkinson's Disease: a quest for "antiPDbiotics" (Co-PI)

Mantero Belard Prize 2016 - MB-40-2016

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Santa Casa da Misericórdia de Lisboa

2016 - 2016

The impairment of neuronal metabolism by gut microbiome effectors

FMUC-BST-2016-221

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Faculdade de Medicina, Universidade de Coimbra & Banco Santander

2016 - 2018

MICROCARE - Microbiome of diabetic ulcers: early diagnosis, prognosis and therapy (Co-PI)

FIS-2015-01_DIA_20150630-144

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Infarmed - Fundo para a Investigação em Saúde

2015 - 2017

Combination therapy synergistically accelerates diabetic wound closure

EFSD/Novartis Programme 2015

Other

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: European Association for the Study of Diabetes

2014 - 2015

Produção e comercialização global de compostos microbianos essenciais para investigação

InovC 2014

Principal investigator

Universidade de Coimbra

Funders: European Regional Development Fund

2013 - 2015

Biosynthesis of rare methylmannose polysaccharides in nontuberculous mycobacteria (PI)

PTDC/BIA-MIC/2779/2012

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2013 - 2015

Ambiguity and virulence in a human pathogen

PTDC/BBB-BEP/0695/2012

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular; Universidade do Porto Instituto de Biologia Molecular e Celular

Funders: Fundação para a Ciência e a Tecnologia

2012 - 2014

Unravelling the early steps in the biosynthesis of the mycobacterial MGLP (PI)

Grant 120123

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Mizutani Foundation for Glycoscience

2011 - 2014

Pathway for the synthesis of the mycobacterial MGLP. Biochemical and structural characterization of the key enzymes (PI)

PTDC/BIA-PRO/110523/2009

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2011 - 2013

The enigmatic mycobacterial maltokinase (PI)

PTDC/BIA-BCM/112459/2009

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2009 - 2010

Characterization and evolution of a rare glycosyltransferase from the anti-tumor producing bacteria of the genus Actinosynnema (PI)

Acordo cultural 2010 Eslováquia 124626903612592

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

2008 - 2010

Cloning, expression and regulation of genes for the synthesis of compatible solutes in Thermus thermophilus

Acção Nº E-9/08

Researcher

Universidade de Coimbra

Funders: Conselho de Reitores das Universidades Portuguesas, Portugal

2005 - 2008

Compatible solutes from extremophiles: screening, biosynthesis and heterologous production

POCI/V.5/A0005/2005

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2005 - 2006

O Mundo dos Micróbios - Colecção Portuguesa de Bactérias (CPB) e Laboratório Acreditado de Controlo Microbiológico

REEQ/851/BIO/2005

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2005 - 2008

Nature´s shields to environmental stress. Biosynthesis of compatible solutes in extremely radiation-resistant Rubrobacter spp.

POCI/BIA-MIC/56511/2004

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2004 - 2006

HOTSOLUTES - New applications for compatible solutes from Extremophiles

COOP-CT-2003-508644

Post-doc Fellow

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: European Commission

2001 - 2004

New compatible solutes from thermophiles and hyperthermophiles: screening, identification and physiological role

POCTI/BIO/42331/2001

PhD Student Fellow

IMAR - Centro Interdisciplinar de Coimbra

Funders: Fundação para a Ciência e a Tecnologia

2001 - 2004

Towards the Utilization of Cell-Reactors for the Production of Mannosylglycerate, an Enzyme Stabilizer from Hyperthermophiles

POCTI/BIO/35715/1999

PhD Student Fellow

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica

Funders: Fundação para a Ciência e a Tecnologia

2001 - 2003

HYPERSOLUTES - Exploiting new solutes from hyperthermophiles for the preservation of biomaterials: cell factories for production of hypersolutes

QLK3-CT-2000-00640

PhD Student Fellow

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica

Funders: European Commission

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