Nélio da Mota Gonçalves

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Information about journal articles, updated at 05-12-2021, from platform CIÊNCIAVITAE.

Cancer Stem Cells and Nucleolin as Drivers of Carcinogenesis

Laura Sofia Carvalho; Nélio Gonçalves; Nuno André Fonseca; João Nuno Moreira, Pharmaceuticals. 60 - 60. 1. 14. 2021. https://doi.org/10.3390/ph14010060 . 10.3390/ph14010060 . Pharmaceuticals

GMP-grade nanoparticle targeted to nucleolin downregulates tumor molecular signature, blocking growth and invasion, at low systemic exposure

Nuno A. Fonseca; Ana C. Gregório; Vera M. Mendes; Rui Lopes; Teresa Abreu; Nélio Gonçalves; Bruno Manadas; et al, Nano Today. 2021. https://doi.org/10.1016/j.nantod.2021.101095 . 10.1016/j.nantod.2021.101095 . Nano Today

Current challenges and emerging opportunities of CAR-T cell therapies

Abreu, Teresa; Fonseca, Nuno A.; Gonçalves, Nélio; Moreira, João Nuno, Journal of Controlled Release. 246 - 261. 319. 2020. http://www.scopus.com/inward/record.url?eid=2-s2.0-85077491524&partnerID=MN8TOARS . 10.1016/j.jconrel.2019.12.047 . published Journal of Controlled Release

Synaptic and memory dysfunction in a ß-amyloid model of early Alzheimer's disease depends on increased formation of ATP-derived extracellular adenosine

Gonçalves, Francisco Queiroz (9913-5AC8-052C); Lopes, João; Silva, Henrique B.; Lemos, Cristina; Silva, António C.; Gonçalves, Nélio; Tomé, Ângelo R.; et al, Neurobiology of Disease. 132. 2019. http://dx.doi.org/10.1016/j.nbd.2019.104570 . 10.1016/j.nbd.2019.104570 . published Neurobiology of Disease

Metabotropic glutamate type 5 receptor requires contactin-associated protein 1 to control memory formation

Morató, Xavier; Luján, R.; Gonçalves, Nélio; Watanabe, M.; Altafaj, X.; Carvalho, Ana Luisa; Fernández-Dueñas, V.; Cunha, Rodrigo A.; Ciruela, Francisco, Human molecular genetics. 3528 - 3541. 20. 27. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85054354803&partnerID=MN8TOARS . 10.1093/hmg/ddy264 . published Human molecular genetics

Adenosine A2A receptors in the rat prelimbic medial prefrontal cortex control delay-based cost-benefit decision making

Leffa, D.T.; Pandolfo, P.; Gonçalves, Nélio; Machado, Nuno J.; de Souza, Caroline M.; Real, Joana; Silva, António Carvalho; et al, Frontiers in Molecular Neuroscience. 11. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85059003991&partnerID=MN8TOARS . 10.3389/fnmol.2018.00475 . published Frontiers in Molecular Neuroscience

Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Triggered by Convulsions

Canas, Paula Margarida Gomes (1C11-C5F1-BC01); Lisiane O. Porciúncula; Simões, Ana; Augusto, Elisabete; Henrique B. Silva; Machado, Nuno J.; Gonçalves, Nélio; et al, eneuro. ENEURO.0385 - 18.2018. 2018. https://doi.org/10.1523/ENEURO.0385-18.2018 . 10.1523/ENEURO.0385-18.2018 . published eneuro

Caffeine alleviates progressive motor deficits in a transgenic mouse model of spinocerebellar ataxia

Gonçalves, Nélio; Simões, Ana Teresa Antunes (E715-7062-B946); Prediger, Rui D.; Hirai, H.; Cunha, Rodrigo A.; Pereira de Almeida, Luis Fernando Morgado, Annals of Neurology. 407 - 418. 3. 81. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85013441188&partnerID=MN8TOARS . 10.1002/ana.24867 . published Annals of Neurology

Adenosine A2A receptors in the amygdala control synaptic plasticity and contextual fear memory

Simões, Ana; Gonçalves, Nélio; Kaster, Manuella; Simões, Ana Teresa Antunes (E715-7062-B946); Nunes, A.; Pereira de Almeida, Luis Fernando Morgado; Goosens, K.A.; Rial, Daniel; Cunha, Rodrigo A., Neuropsychopharmacology. 2862 - 2871. 12. 41. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84978777019&partnerID=MN8TOARS . 10.1038/npp.2016.98 . published Neuropsychopharmacology

Depression as a glial-based synaptic dysfunction

Rial, Daniel; Lemos, C.; Pinheiro, H.; Duarte, J.M.; Gonçalves, Francisco Queiroz (9913-5AC8-052C); Real, Joana; Prediger, R.D.; et al, Frontiers in Cellular Neuroscience. 1 - 11. JAN2016. 9. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84957876863&partnerID=MN8TOARS . 10.3389/fncel.2015.00521 . published Frontiers in Cellular Neuroscience

Early synaptic deficits in the APP/PS1 mouse model of Alzheimer’s disease involve neuronal adenosine A2A receptors

Viana da Silva, Silvia; Haberl, Matthias Georg; Zhang, Pei; Bethge, Philipp; Lemos, Cristina; Gonçalves, Nélio; Gorlewicz, Adam; et al, Nature Communications. 1. 7. 2016. http://dx.doi.org/10.1038/ncomms11915 . 10.1038/ncomms11915 . published Nature Communications

Neuropeptide Y mitigates neuropathology and motor deficits in mouse models of Machado-Joseph disease

Duarte-Neves, Joana; Gonçalves, Nélio; Cunha-Santos, Janete; Simões, Ana Teresa Antunes (E715-7062-B946); den Dunnen, W.F.A.; Hirai, H.; Kügler, Sebastian; Cavadas, Claudia; Pereira de Almeida, Luis Fernando Morgado, Human Molecular Genetics. 5451 - 5463. 19. 24. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84943793236&partnerID=MN8TOARS . 10.1093/hmg/ddv271 . published Human Molecular Genetics

Optogenetic activation of intracellular adenosine A2A receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and impair memory

Li, P.; Rial, Daniel; Canas, Paula Margarida Gomes (1C11-C5F1-BC01); Yoo, J.-H.; Li, W.; Zhou, X.; Wang, Y.; et al, Molecular Psychiatry. 1339 - 1349. 11. 20. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84946498281&partnerID=MN8TOARS . 10.1038/mp.2014.182 . published Molecular Psychiatry

Erratum: Optogenetic activation of intracellular adenosine A2A Receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and impair memory (Molecular Psychiatry (2015) 20, 1339-1349 DOI:10.1038/mp.2014.182)

Li, P.; Rial, Daniel; Canas, Paula Margarida Gomes (1C11-C5F1-BC01); Yoo, J.-H.; Li, W.; Zhou, X.; Wang, Y.; et al, Molecular Psychiatry. 11. 20. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84946495951&partnerID=MN8TOARS . 10.1038/mp.2015.43 . published Molecular Psychiatry

Calpain inhibition reduces ataxin-3 cleavage alleviating neuropathology and motor impairments in mouse models of machado-Joseph disease

Simões, Ana Teresa Antunes (E715-7062-B946); Gonçalves, Nélio; Nobre, Rui Jorge; Duarte, Carlos B.; Pereira de Almeida, Luis Fernando Morgado, Human Molecular Genetics. 4932 - 4944. 18. 23. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84906821927&partnerID=MN8TOARS . 10.1093/hmg/ddu209 . published Human Molecular Genetics

Potentiation of radiotherapy by a localized antiangiogenic gene therapy

Crokart, Nathalie; Danhier, Fabienne; Daugimont, Liévin; Gonçalves, Nélio; Jordan, B.F.; Grégoire, V.; Feron, Olivier; et al, Radiotherapy and Oncology. 252 - 258. 2. 107. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879019526&partnerID=MN8TOARS . 10.1016/j.radonc.2013.03.018 . published Radiotherapy and Oncology

Activation of microglial cells triggers a release of brain-derived neurotrophic factor (BDNF) inducing their proliferation in an adenosine A2A receptor-dependent manner: A2A receptor blockade prevents BDNF release and proliferation of microglia

Gomes, Catarina; Ferreira, Raquel; George, Jimmy; Sanches, Rui; Rodrigues, Diana I; Gonçalves, Nélio; Cunha, Rodrigo A., Journal of Neuroinflammation. 1. 10. 2013. http://dx.doi.org/10.1186/1742-2094-10-16 . 10.1186/1742-2094-10-16 . published Journal of Neuroinflammation

Caffeine and adenosine A2A receptor inactivation decrease striatal neuropathology in a lentiviral-based model of Machado-Joseph disease

Gonçalves, Nélio; Simões, Ana Teresa Antunes (E715-7062-B946); Cunha, Rodrigo A.; Pereira de Almeida, Luis Fernando Morgado, Annals of Neurology. 655 - 666. 5. 73. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878306815&partnerID=MN8TOARS . 10.1002/ana.23866 . published Annals of Neurology

Calpastatin-mediated inhibition of calpains in the mouse brain prevents mutant ataxin 3 proteolysis, nuclear localization and aggregation, relieving Machado-Joseph disease

Simões, Ana Teresa Antunes (E715-7062-B946); Gonçalves, Nélio; Koeppen, Arnulf; Déglon, Nicole; Kügler, Sebastian; Duarte, Carlos B.; Pereira de Almeida, Luis Fernando Morgado, Brain. 2428 - 2439. 8. 135. 2012. http://dx.doi.org/10.1093/brain/aws177 . 10.1093/brain/aws177 . published Brain

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Information of exclusive responsibility of the researcher 05-12-2021 , from platform CIÊNCIAVITAE.

2018/07 - 2021/07

A2A receptors control axon formation during neuronal development: new strategies to arrest epileptogenesis.

PTDC/MED-NEU/28160/2017

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2017/01/01 - 2019/05/31

CANCEL-STEM: Tackling CANcer STEM CELls: a challenge and an opportunity to advance in anti-cancer therapy

POCI-01-0145-FEDER-016390

Post-doc Fellow

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2017/01 - 2019/05

Towards a single therapy against triple negative breast cancer and neuroblastoma by nucleolin-mediated multicellular targeting with a synergistic drug combination.

ENMed/0005/2015

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2016/05 - 2019/04

Role of astrocytes in the control of memory-focus on adenosine A2A receptors

Provided by PTCRIS: 142785

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2016/05 - 2018/10

Hybrid ionotropic receptors: a new concept of receptor

Provided by PTCRIS: 142196

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2015/11 - 2018/10

P2Y1 receptor-CRMP2 control synaptic loss and memory impairment in early Alzheimer’s Disease

NIRG-15-361884

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Alzheimer's Association

2014/09 - 2015

The up-regulation of hippocampal adenosine A2A receptors is necessary and sufficient to trigger memory dysfunction in Alzheimer’s disease.

MB-98-2014

Post-doc Fellow

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Santa Casa da Misericórdia de Lisboa

2014 - 2016

Role of adenosine A2A receptors in the accumbens and amygdala in the control of chronic stress neuropathology.

-

Post-doc Fellow

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Brain and Behavior Research Foundation

2013 - 2016

Caffeine alleviation of MJD/SCA3

2013 41(1)

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: National Ataxia Foundation (NAF)

2013/12 - 2015

New Treatments for Stress-induced Dysregulation of Circuits Regulating Reward, Fear, and Habit Learning

09-68-ESR-FP-010

Post-doc Fellow

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Defense Advanced Research Projects Agency

2012/04 - 2014/09

Role of accumbens and amygdala in the control of chronic stress neuropathology

Provided by PTCRIS: 122254

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2011/10 - 2013/11

New Treatments for Stress-induced Dysregulation of Circuits Regulating Reward, Fear, and Habit Learning

DARPA-09-68-ESR-FP-010

Research Fellow

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Defense Advanced Research Projects Agency

2011/04/01 - 2014/08/30

Cell to cell transport of alpha-synuclein in Parkinson´s Disease. The progression factor?

PTDC/SAU-NMC/109955/2009

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2010/02 - 2013/04

The role of calpain-mediated proteolysis of ataxin-3 in Machado-Joseph disease: a molecular therapy approach with viral vectors

99307

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2010/03 - 2012/02

Role of adenosine A2A receptors in microglia and glutamatergic synapses in the control of synaptic plasticity and brain damage

108668

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2007/04/02 - 2007/06/28

Tumoral microenvironment study after the electroporation of a plasmid coding for an antiangiogenic factor.

LSHB-CT-2005-512127

Other

Université catholique de Louvain Louvain Drug Research Institute

Funders: European Commission Sixth Framework Programme

2007 - 2013

Aging, Stress and Chronic Diseases: From Mechanisms to Therapeutics

CENTRO-07-ST24-FEDER-002006

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Universidade de Coimbra Instituto de Investigação Interdisciplinar

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