Paula Agostinho

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Researcher

Neuromodulation

Publications

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Information about journal articles, updated at 21-11-2021, from platform CIÊNCIAVITAE.

Astrocytes and Adenosine A2A Receptors: Active Players in Alzheimer’s Disease

Agostinho, Paula, Frontiers in Neuroscience. 15. 2021. http://dx.doi.org/10.3389/fnins.2021.666710 . 10.3389/fnins.2021.666710 . Frontiers in Neuroscience

Convergence of adenosine and GABA signaling for synapse stabilization during development

Agostinho, Paula, Science. 6568. 374. 2021. http://dx.doi.org/10.1126/science.abk2055 . 10.1126/science.abk2055 . Science

l -a-aminoadipate causes astrocyte pathology with negative impact on mouse hippocampal synaptic plasticity and memory

Marlene F. Pereira; Inês M. Amaral; Cátia Lopes; Catarina Leitão; Daniela Madeira; João P. Lopes; Francisco Q. Gonçalves; et al, The FASEB Journal. 8. 35. 2021. https://doi.org/10.1096/fj.202100336R . 10.1096/fj.202100336R . The FASEB Journal

Association Between Adenosine A2A Receptors and Connexin 43 Regulates Hemichannels Activity and ATP Release in Astrocytes Exposed to Amyloid-ß Peptides

Daniela Madeira; Liliana Dias; Patrícia Santos; Rodrigo A. Cunha; Paula M. Canas; Paula Agostinho, Molecular Neurobiology. 2021. https://doi.org/10.1007/s12035-021-02538-z . 10.1007/s12035-021-02538-z . Molecular Neurobiology

Crosstalk Between ATP-P2X7 and Adenosine A2A Receptors Controlling Neuroinflammation in Rats Subject to Repeated Restraint Stress

Dias, Liliana; Lopes, Cátia R.; Gonçalves, Francisco Q.; Nunes, Ana; Pochmann, Daniela; Machado, Nuno J.; Tomé, Angelo R.; Agostinho, Paula; Cunha, Rodrigo A., Frontiers in Cellular Neuroscience. 15. 2021. http://dx.doi.org/10.3389/fncel.2021.639322 . 10.3389/fncel.2021.639322 . published Frontiers in Cellular Neuroscience

Exercise decreases aberrant corticostriatal plasticity in an animal model of L-DOPA-induced dyskinesia

Speck, Ana E.; Aguiar, Aderbal S.; Ferreira, Samira G.; Silva, Henrique B.; Tomé, Angelo R.; Agostinho, Paula; Cunha, Rodrigo A.; Prediger, Rui D., American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 2021. http://dx.doi.org/10.1152/ajpregu.00295.2020 . 10.1152/ajpregu.00295.2020 . American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Purinergic signaling orchestrating neuron-glia communication

Paula Agostinho; Daniela Madeira; Liliana Dias; Ana Patrícia Simões; Rodrigo A. Cunha; Paula M. Canas, Pharmacological Research. 105253 - 105253. 2020. https://doi.org/10.1016/j.phrs.2020.105253 . 10.1016/j.phrs.2020.105253 . Pharmacological Research

Synthesis, biological evaluation, and molecular modeling of nitrile-containing compounds: Exploring multiple activities as anti-Alzheimer agents

Silva, Daniel; Mendes, Eduarda; Summers, Eleanor J.; Neca, Ana; Jacinto, Ana C.; Reis, Telma; Agostinho, Paula; et al, Drug Development Research. 215 - 231. 2. 81. 2020. http://dx.doi.org/10.1002/ddr.21594 . 10.1002/ddr.21594 . Drug Development Research

Enhanced ATP release and CD73-mediated adenosine formation sustain adenosine A2A receptor over-activation in a rat model of Parkinson's disease.

Agostinho, Paula, British journal of pharmacology. 2019. https://doi.org/10.1111/bph.14771 . 10.1111/bph.14771 . British journal of pharmacology

Synaptic and memory dysfunction in a ß-amyloid model of early Alzheimer's disease depends on increased formation of ATP-derived extracellular adenosine

Gonçalves, Francisco Q.; Lopes, João P.; Silva, Henrique B.; Lemos, Cristina; Silva, António C.; Gonçalves, Nélio; Tomé, Ângelo R.; et al, Neurobiology of Disease. 132. 2019. http://dx.doi.org/10.1016/j.nbd.2019.104570 . 10.1016/j.nbd.2019.104570 . Neurobiology of Disease

Blockade of adenosine A<inf>2A</inf> receptors recovers early deficits of memory and plasticity in the triple transgenic mouse model of Alzheimer's disease

Silva, A.C.; Lemos, C.; Gonçalves, F.Q.; Pliássova, A.V.; Machado, N.J.; Silva, H.B.; Canas, P.M.; et al, Neurobiology of Disease. 72 - 81. 117. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85048494541&partnerID=MN8TOARS . 10.1016/j.nbd.2018.05.024 . Neurobiology of Disease

Neuronal adenosine A2A receptors are critical mediators of neurodegeneration triggered by convulsions

Canas, P.M.; Porciúncula, L.O.; Simões, A.P.; Augusto, E.; Silva, H.B.; Machado, N.J.; Gonçalves, N.; et al, eNeuro. 6. 5. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85059796352&partnerID=MN8TOARS . 10.1523/ENEURO.0385-18.2018 . eNeuro

Anthocyanins control neuroinflammation and consequent memory dysfunction in mice exposed to lipopolysaccharide

Carvalho, F.B.; Gutierres, J.M.; Bueno, A.; Agostinho, P.; Zago, A.M.; Vieira, J.; Frühauf, P.; et al, Molecular Neurobiology. 3350 - 3367. 5. 54. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-84966705153&partnerID=MN8TOARS . 10.1007/s12035-016-9900-8 . Molecular Neurobiology

Caffeine Reverts Memory But Not Mood Impairment in a Depression-Prone Mouse Strain with Up-Regulated Adenosine A<inf>2A</inf> Receptor in Hippocampal Glutamate Synapses

Machado, N.J.; Simões, A.P.; Silva, H.B.; Ardais, A.P.; Kaster, M.P.; Garção, P.; Rodrigues, D.I.; et al, Molecular Neurobiology. 1552 - 1563. 2. 54. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-84957698500&partnerID=MN8TOARS . 10.1007/s12035-016-9774-9 . Molecular Neurobiology

Mitochondria in Excitatory and Inhibitory Synapses have Similar Susceptibility to Amyloid-ß Peptides Modeling Alzheimer's Disease

Amorim, J.A.; Canas, P.M.; Tomé, A.R.; Rolo, A.P.; Agostinho, P.; Palmeira, C.M.; Cunha, R.A., Journal of Alzheimer's Disease. 525 - 536. 2. 60. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85029613373&partnerID=MN8TOARS . 10.3233/JAD-170356 . Journal of Alzheimer's Disease

Oncostatin M promotes excitotoxicity by inhibiting glutamate uptake in astrocytes: Implications in HIV-associated neurotoxicity

Moidunny, S.; Matos, M.; Wesseling, E.; Banerjee, S.; Volsky, D.J.; Cunha, R.A.; Agostinho, P.; Boddeke, H.W.; Roy, S., Journal of Neuroinflammation. 1. 13. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84973515337&partnerID=MN8TOARS . 10.1186/s12974-016-0613-8 . Journal of Neuroinflammation

Age-Related Changes in the Synaptic Density of Amyloid-ß Protein Precursor and Secretases in the Human Cerebral Cortex

Pliássova, A.; Canas, P.M.; Xavier, A.C.; Da Silva, B.S.; Cunha, R.A.; Agostinho, P., Journal of Alzheimer's Disease. 1209 - 1214. 4. 52. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84974575119&partnerID=MN8TOARS . 10.3233/JAD-160213 . Journal of Alzheimer's Disease

Depression as a glial-based synaptic dysfunction

Rial, D.; Lemos, C.; Pinheiro, H.; Duarte, J.M.; Gonçalves, F.Q.; Real, J.I.; Prediger, R.D.; et al, Frontiers in Cellular Neuroscience. 1 - 11. JAN2016. 9. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84957876863&partnerID=MN8TOARS . 10.3389/fncel.2015.00521 . Frontiers in Cellular Neuroscience

Stimulation of brain glucose uptake by cannabinoid CB<inf>2</inf> receptors and its therapeutic potential in Alzheimer's disease

Köfalvi, A.; Lemos, C.; Martín-Moreno, A.M.; Pinheiro, B.S.; García-García, L.; Pozo, M.A.; Valério-Fernandes, Â.; et al, Neuropharmacology. 519 - 529. 110. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84988025899&partnerID=MN8TOARS . 10.1016/j.neuropharm.2016.03.015 . Neuropharmacology

The Association of Amyloid-ß Protein Precursor With a- and ß-Secretases in Mouse Cerebral Cortex Synapses Is Altered in Early Alzheimer’s Disease

Pliássova, A.; Lopes, J.P.; Lemos, C.; Oliveira, C.R.; Cunha, R.A.; Agostinho, P., Molecular Neurobiology. 5710 - 5721. 8. 53. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84945268204&partnerID=MN8TOARS . 10.1007/s12035-015-9491-9 . Molecular Neurobiology

Localization and Trafficking of Amyloid-ß Protein Precursor and Secretases: Impact on Alzheimer's Disease

Agostinho, P.; Pliássova, A.; Oliveira, C.R.; Cunha, R.A., Journal of Alzheimer's Disease. 329 - 347. 2. 45. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84925344255&partnerID=MN8TOARS . 10.3233/JAD-142730 . Journal of Alzheimer's Disease

Caffeine acts through neuronal adenosine A<inf>2A</inf> receptors to prevent mood and memory dysfunction triggered by chronic stress

Kaster, M.P.; Machado, N.J.; Silva, H.B.; Nunes, A.; Ardais, A.P.; Santana, M.; Baqi, Y.; et al, Proceedings of the National Academy of Sciences of the United States of America. 7833 - 7838. 25. 112. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84934894606&partnerID=MN8TOARS . 10.1073/pnas.1423088112 . Proceedings of the National Academy of Sciences of the United States of America

Does Caffeine Consumption Modify Cerebrospinal Fluid Amyloid-ß Levels in Patients with Alzheimer's Disease?

Travassos, M.; Santana, I.; Baldeiras, I.; Tsolaki, M.; Gkatzima, O.; Genc, S.; Yener, G.G.; et al, Journal of Alzheimer's Disease. 1069 - 1078. 4. 47. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84939450783&partnerID=MN8TOARS . 10.3233/JAD-150374 . Journal of Alzheimer's Disease

Deletion of Adenosine A<inf>2A</inf> Receptors from Astrocytes Disrupts Glutamate Homeostasis Leading to Psychomotor and Cognitive Impairment: Relevance to Schizophrenia

Matos, M.; Shen, H.-Y.; Augusto, E.; Wang, Y.; Wei, C.J.; Wang, Y.T.; Agostinho, P.; et al, Biological Psychiatry. 763 - 774. 11. 78. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84957928612&partnerID=MN8TOARS . 10.1016/j.biopsych.2015.02.026 . Biological Psychiatry

Subsynaptic localization of nicotinic acetylcholine receptor subunits: A comparative study in the mouse and rat striatum

Garção, P.; Oliveira, C.R.; Cunha, R.A.; Agostinho, P., Neuroscience Letters. 106 - 110. 566. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84896142912&partnerID=MN8TOARS . 10.1016/j.neulet.2014.02.018 . Neuroscience Letters

Synaptic and sub-synaptic localization of amyloid-ß protein precursor in the rat hippocampus

Rodrigues, D.I.; Gutierres, J.; Pliássova, A.; Oliveira, C.R.; Cunha, R.A.; Agostinho, P., Journal of Alzheimer's Disease. 981 - 992. 4. 40. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901755722&partnerID=MN8TOARS . 10.3233/JAD-132030 . Journal of Alzheimer's Disease

Prolonged nicotine exposure down-regulates presynaptic NMDA receptors in dopaminergic terminals of the rat nucleus accumbens

Salamone, A.; Zappettini, S.; Grilli, M.; Olivero, G.; Agostinho, P.; Tomé, A.R.; Chen, J.; et al, Neuropharmacology. 488 - 497. 79. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84892589518&partnerID=MN8TOARS . 10.1016/j.neuropharm.2013.12.014 . Neuropharmacology

Anthocyanins restore behavioral and biochemical changes caused by streptozotocin-induced sporadic dementia of Alzheimer's type

Gutierres, J.M.; Carvalho, F.B.; Schetinger, M.R.C.; Marisco, P.; Agostinho, P.; Rodrigues, M.; Rubin, M.A.; et al, Life Sciences. 7 - 17. 1-2. 96. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84892799447&partnerID=MN8TOARS . 10.1016/j.lfs.2013.11.014 . Life Sciences

Cellular prion protein is present in dopaminergic neurons and modulates the dopaminergic system

Rial, D.; Pamplona, F.A.; Moreira, E.L.G.; Moreira, K.M.; Hipolide, D.; Rodrigues, D.I.; Dombrowski, P.A.; et al, European Journal of Neuroscience. 2479 - 2486. 3. 40. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84905364655&partnerID=MN8TOARS . 10.1111/ejn.12600 . European Journal of Neuroscience

Neuroprotective effect of anthocyanins on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia in rats

Gutierres, J.M.; Carvalho, F.B.; Schetinger, M.R.C.; Agostinho, P.; Marisco, P.C.; Vieira, J.M.; Rosa, M.M.; et al, International Journal of Developmental Neuroscience. 88 - 97. 1. 33. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84892473219&partnerID=MN8TOARS . 10.1016/j.ijdevneu.2013.12.006 . International Journal of Developmental Neuroscience

Functional interaction between pre-synaptic a6ß2-containing nicotinic and adenosine A<inf>2A</inf> receptors in the control of dopamine release in the rat striatum

Garção, P.; Szabõ, E.C.; Wopereis, S.; Castro, A.A.; Tomé, A.R.; Prediger, R.D.; Cunha, R.A.; Agostinho, P.; Köfalvi, A., British Journal of Pharmacology. 1600 - 1611. 7. 169. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880322083&partnerID=MN8TOARS . 10.1111/bph.12234 . British Journal of Pharmacology

Synthesis, pharmacological assessment, and molecular modeling of acetylcholinesterase/butyrylcholinesterase inhibitors: Effect against amyloid-ß-induced neurotoxicity

Silva, D.; Chioua, M.; Samadi, A.; Agostinho, P.; Garção, P.; Lajarín-Cuesta, R.; De Los Ríos, C.; et al, ACS Chemical Neuroscience. 547 - 565. 4. 4. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876529529&partnerID=MN8TOARS . 10.1021/cn300178k . ACS Chemical Neuroscience

Antagonistic interaction between adenosine A <inf>2A</inf> Receptors and Na <sup>+</sup> /K <sup>+</sup> -ATPase-a <inf>2</inf> controlling glutamate uptake in astrocytes

Matos, M.; Augusto, E.; Agostinho, P.; Cunha, R.A.; Chen, J.-F., Journal of Neuroscience. 18492 - 18502. 47. 33. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887851711&partnerID=MN8TOARS . 10.1523/JNEUROSCI.1828-13.2013 . Journal of Neuroscience

Spatial memory impairments in a prediabetic rat model

Soares, E.; Prediger, R.D.; Nunes, S.; Castro, A.A.; Viana, S.D.; Lemos, C.; De Souza, C.M.; et al, Neuroscience. 565 - 577. 250. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84882959210&partnerID=MN8TOARS . 10.1016/j.neuroscience.2013.07.055 . Neuroscience

Blockade of adenosine A 2A receptors prevents interleukin-1ß-induced exacerbation of neuronal toxicity through a p38 mitogen-activated protein kinase pathway

Simões, A.P.; Duarte, J.A.; Agasse, F.; Canas, P.M.; Tomé, A.R.; Agostinho, P.; Cunha, R.A., Journal of Neuroinflammation. 9. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865050131&partnerID=MN8TOARS . 10.1186/1742-2094-9-204 . Journal of Neuroinflammation

Astrocytic adenosine A<inf>2A</inf> receptors control the amyloid-ß peptide-induced decrease of glutamate uptake

Matos, M.; Augusto, E.; MacHado, N.J.; Dos Santos-Rodrigues, A.; Cunha, R.A.; Agostinho, P., Journal of Alzheimer's Disease. 555 - 567. 3. 31. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865592766&partnerID=MN8TOARS . 10.3233/JAD-2012-120469 . Journal of Alzheimer's Disease

Caffeine consumption prevents diabetes-induced memory impairment and synaptotoxicity in the hippocampus of nonczno10/ltj mice

Duarte, J.M.N.; Agostinho, P.M.; Carvalho, R.A.; Cunha, R.A., PLoS ONE. 4. 7. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859733227&partnerID=MN8TOARS . 10.1371/journal.pone.0021899 . PLoS ONE

Presynaptic CB1 cannabinoid receptors control frontocortical serotonin and glutamate release - Species differences

Ferreira, S.G.; Teixeira, F.M.; Garção, P.; Agostinho, P.; Ledent, C.; Cortes, L.; MacKie, K.; Köfalvi, A., Neurochemistry International. 219 - 226. 2. 61. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863463752&partnerID=MN8TOARS . 10.1016/j.neuint.2012.05.009 . Neurochemistry International

Adenosine A <inf>2A</inf> receptors modulate glutamate uptake in cultured astrocytes and gliosomes

Matos, M.; Augusto, E.; Santos-Rodrigues, A.D.; Schwarzschild, M.A.; Chen, J.-F.; Cunha, R.A.; Agostinho, P., GLIA. 702 - 716. 5. 60. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862776724&partnerID=MN8TOARS . 10.1002/glia.22290 . GLIA

Adenosine receptors and brain diseases: Neuroprotection and neurodegeneration

Gomes, C.V.; Kaster, M.P.; Tomé, A.R.; Agostinho, P.M.; Cunha, R.A., Biochimica et Biophysica Acta - Biomembranes. 1380 - 1399. 5. 1808. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953220421&partnerID=MN8TOARS . 10.1016/j.bbamem.2010.12.001 . Biochimica et Biophysica Acta - Biomembranes

Cdk5: Multitasking between physiological and pathological conditions

Lopes, J.P.; Agostinho, P., Progress in Neurobiology. 49 - 63. 1. 94. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955109480&partnerID=MN8TOARS . 10.1016/j.pneurobio.2011.03.006 . Progress in Neurobiology

Enhanced role of adenosine A 2A receptors in the modulation of LTP in the rat hippocampus upon ageing

Costenla, A.R.; Diógenes, M.J.; Canas, P.M.; Rodrigues, R.J.; Nogueira, C.; Maroco, J.; Agostinho, P.M.; et al, European Journal of Neuroscience. 12 - 21. 1. 34. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80955177501&partnerID=MN8TOARS . 10.1111/j.1460-9568.2011.07719.x . European Journal of Neuroscience

Adenosine A<inf>2A</inf> receptors control neuroinflammation and consequent hippocampal neuronal dysfunction

Rebola, N.; Simões, A.P.; Canas, P.M.; Tomé, A.R.; Andrade, G.M.; Barry, C.E.; Agostinho, P.M.; Lynch, M.A.; Cunha, R.A., Journal of Neurochemistry. 100 - 111. 1. 117. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952548073&partnerID=MN8TOARS . 10.1111/j.1471-4159.2011.07178.x . Journal of Neurochemistry

Chronic caffeine consumption prevents memory disturbance in different animal models of memory decline

Cunha, R.A.; Agostinho, P.M., Journal of Alzheimer's Disease. SUPPL.1. 20. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954537925&partnerID=MN8TOARS . 10.3233/JAD-2010-1408 . Journal of Alzheimer's Disease

Caffeine and an adenosine A<inf>2A</inf> receptor antagonist prevent memory impairment and synaptotoxicity in adult rats triggered by a convulsive episode in early life

Cognato, G.P.; Agostinho, P.M.; Hockemeyer, J.; Müller, C.E.; Souza, D.O.; Cunha, R.A., Journal of Neurochemistry. 453 - 462. 2. 112. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-72849150168&partnerID=MN8TOARS . 10.1111/j.1471-4159.2009.06465.x . Journal of Neurochemistry

Neurodegeneration in an Aß-induced model of Alzheimer's disease: The role of Cdk5

Lopes, J.P.; Oliveira, C.R.; Agostinho, P., Aging Cell. 64 - 77. 1. 9. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-76249103674&partnerID=MN8TOARS . 10.1111/j.1474-9726.2009.00536.x . Aging Cell

Neuroinflammation, oxidative stress and the pathogenesis of Alzheimer's disease

Agostinho, P.; Cunha, R.A.; Oliveira, C., Current Pharmaceutical Design. 2766 - 2778. 25. 16. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957970155&partnerID=MN8TOARS . Current Pharmaceutical Design

Activation of cell cycle proteins in transgenic mice in response to neuronal loss but not amyloid-ß and tau pathology

Lopes, J.P.; Blurton-Jones, M.; Yamasaki, T.R.; Agostinho, P.; Laferla, F.M., Journal of Alzheimer's Disease. 541 - 549. 3. 16. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-65549145514&partnerID=MN8TOARS . 10.3233/JAD-2009-0993 . Journal of Alzheimer's Disease

Cell cycle re-entry in Alzheimer's disease: A major neuropathological characteristic?

Lopes, J.P.; Oliveira, C.R.; Agostinho, P., Current Alzheimer Research. 205 - 212. 3. 6. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-67149106183&partnerID=MN8TOARS . 10.2174/156720509788486590 . Current Alzheimer Research

Cdk5 acts as a mediator of neuronal cell cycle re-entry triggered by amyloid-ß and prion peptides

Lopes, J.P.; Oliveira, C.R.; Agostinho, P., Cell Cycle. 97 - 104. 1. 8. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-60749123603&partnerID=MN8TOARS . Cell Cycle

Galantamine protects against oxidative stress induced by amyloid-beta peptide in cortical neurons

Melo, J.B.; Sousa, C.; Garção, P.; Oliveira, C.R.; Agostinho, P., European Journal of Neuroscience. 455 - 464. 3. 29. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-59149090400&partnerID=MN8TOARS . 10.1111/j.1460-9568.2009.06612.x . European Journal of Neuroscience

Activation of Cell Cycle Proteins in Transgenic Mice in Response to Neuronal Loss but not Amyloid-ß and Tau Pathology

Lopes, Joao P.; Blurton-Jones, Mathew; Yamasaki, Tritia R.; Agostinho, Paula; LaFerla, Frank M., Journal of Alzheimer's Disease. 541 - 549. 3. 16. 2009. http://dx.doi.org/10.3233/jad-2009-0993 . 10.3233/jad-2009-0993 . Journal of Alzheimer's Disease

Overactivation of calcineurin induced by amyloid-beta and prion proteins

Agostinho, P.; Lopes, J.P.; Velez, Z.; Oliveira, C.R., Neurochemistry International. 1226 - 1233. 6. 52. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-40949104298&partnerID=MN8TOARS . 10.1016/j.neuint.2008.01.005 . Neurochemistry International

Amyloid-beta peptide decreases glutamate uptake in cultured astrocytes: Involvement of oxidative stress and mitogen-activated protein kinase cascades

Matos, M.; Augusto, E.; Oliveira, C.R.; Agostinho, P., Neuroscience. 898 - 910. 4. 156. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-53949085542&partnerID=MN8TOARS . 10.1016/j.neuroscience.2008.08.022 . Neuroscience

Prion Protein Aggregation and Neurotoxicity in Cortical Neurons

MELO, J. B.; AGOSTINHO, P.; OLIVEIRA, C. R., Annals of the New York Academy of Sciences. 220 - 229. 1. 1096. 2007. http://dx.doi.org/10.1196/annals.1397.088 . 10.1196/annals.1397.088 . Annals of the New York Academy of Sciences

Susceptibility of hippocampal neurons to Aß peptide toxicity is associated with perturbation of Ca<sup>2+</sup> homeostasis

Resende, R.; Pereira, C.; Agostinho, P.; Vieira, A.P.; Malva, J.O.; Oliveira, C.R., Brain Research. 11 - 21. 1. 1143. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947303240&partnerID=MN8TOARS . 10.1016/j.brainres.2007.01.071 . Brain Research

Role of cyclin-dependent kinase 5 in the neurodegenerative process triggered by amyloid-beta and prion peptides: Implications for Alzheimer's disease and prion-related encephalopathies

Lopes, J.P.; Oliveira, C.R.; Agostinho, P., Cellular and Molecular Neurobiology. 943 - 957. 7. 27. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-37549015597&partnerID=MN8TOARS . 10.1007/s10571-007-9224-3 . Cellular and Molecular Neurobiology

Expression and subcellular localization of a novel nuclear acetylcholinesterase protein

Santos, S.C.R.; Vala, I.; Miguel, C.; Barata, J.T.; Garção, P.; Agostinho, P.; Mendes, M.; et al, Journal of Biological Chemistry. 25597 - 25603. 35. 282. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548490497&partnerID=MN8TOARS . 10.1074/jbc.M700569200 . Journal of Biological Chemistry

Comparative study of microglia activation induced by amyloid-beta and prion peptides: Role in neurodegeneration

Garção, P.; Oliveira, C.R.; Agostinho, P., Journal of Neuroscience Research. 182 - 193. 1. 84. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745782720&partnerID=MN8TOARS . 10.1002/jnr.20870 . Journal of Neuroscience Research

Alzheimer's disease-associated neurotoxic mechanisms and neuroprotective strategies

Pereira, C.; Agostinho, P.; Moreira, P.I.; Cardoso, S.M.; Oliveira, C.R., Current Drug Targets: CNS and Neurological Disorders. 383 - 403. 4. 4. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-23144463734&partnerID=MN8TOARS . 10.2174/1568007054546117 . Current Drug Targets: CNS and Neurological Disorders

Neurodegenerative pathways in Parkinson's disease: Therapeutic strategies

Cardoso, S.M.; Moreira, P.I.; Agostinho, P.; Pereira, C.; Oliveira, C.R., Current Drug Targets: CNS and Neurological Disorders. 405 - 419. 4. 4. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-23144431757&partnerID=MN8TOARS . 10.2174/1568007054546072 . Current Drug Targets: CNS and Neurological Disorders

Involvement of oxidative stress in the enhancement of acetylcholinesterase activity induced by amyloid beta-peptide

Melo, J.B.; Agostinho, P.; Oliveira, C.R., Neuroscience Research. 117 - 127. 1. 45. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037219182&partnerID=MN8TOARS . 10.1016/S0168-0102(02)00201-8 . Neuroscience Research

Neuroprotection strategies: Effect of vinpocetinein in vitro oxidative stress models,Estratégias de neuroprotecção: Efeito da vimpocetina em modelos in vitro de stresse oxidativo

Pereira, C.; Agostinho, P.; Moreira, P.I.; Duarte, A.I.; Santos, M.S.; Oliveira, C.R., Acta Medica Portuguesa. 401 - 406. 6. 16. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-9644310235&partnerID=MN8TOARS . Acta Medica Portuguesa

Involvement of calcineurin in the neurotoxic effects induced by amyloid-beta and prion peptides

Agostinho, P.; Oliveira, C.R., European Journal of Neuroscience. 1189 - 1196. 6. 17. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037363599&partnerID=MN8TOARS . 10.1046/j.1460-9568.2003.02546.x . European Journal of Neuroscience

Amyloid beta-peptide 25-35 reduces [3H]acetylcholine release in retinal neurons. Involvement of metabolic dysfunction

Melo, J.B.; Agostinho, P.; Oliveira, C.R., Amyloid. 221 - 228. 4. 9. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036971111&partnerID=MN8TOARS . Amyloid

Adenosine A(2A) receptors regulate the extracellular accumulation of excitatory amino acids upon metabolic dysfunction in chick cultured retinal cells

Rego, A.C.; Agostinho, P.; Melo, J.; Cunha, R.A.; Oliveira, C.R., Experimental Eye Research. 577 - 587. 5. 70. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033623815&partnerID=MN8TOARS . 10.1006/exer.1999.0815 . Experimental Eye Research

Vinpocetine attenuates the metabolic dysfunction induced by amyloid ß-peptides in PC12 cells

Pereira, C.; Agostinho, P.; Oliveira, C.R., Free Radical Research. 497 - 506. 5. 33. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034492706&partnerID=MN8TOARS . Free Radical Research

Adenosine modulation of D-[<sup>3</sup>H]aspartate release in cultured retina cells exposed to oxidative stress

Agostinho, P.; Caseiro, P.; Rego, A.C.; Duarte, E.P.; Cunha, R.A.; Oliveira, C.R., Neurochemistry International. 255 - 265. 3. 36. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033979263&partnerID=MN8TOARS . 10.1016/S0197-0186(99)00113-8 . Neurochemistry International

Glutamate in life and death of retinal amacrine cells

Duarte, C.B.; Ferreira, I.L.; Santos, P.F.; Carvalho, A.L.; Agostinho, P.M.; Carvalho, A.P., General Pharmacology. 289 - 295. 3. 30. 1998. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032033584&partnerID=MN8TOARS . 10.1016/S0306-3623(97)00360-1 . General Pharmacology

Oxidative stress affects the selective ion permeability of voltage-sensitive Ca<sup>2+</sup> channels in cultured retinal cells

Agostinho, P.; Duarte, C.B.; Carvalho, A.P.; Oliveira, C.R., Neuroscience Research. 323 - 334. 4. 27. 1997. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030951140&partnerID=MN8TOARS . 10.1016/S0168-0102(96)01165-0 . Neuroscience Research

Impairment of excitatory amino acid transporter activity by oxidative stress conditions in retinal cells: Effect of antioxidants

Agostinho, P.; Duarte, C.B.; Oliveira, C.R., FASEB Journal. 154 - 163. 2. 11. 1997. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031027249&partnerID=MN8TOARS . FASEB Journal

Activity of ionotropic glutamate receptors in retinal cells: Effect of ascorbate/Fe2+-induced oxidative stress

Agostinho, P.; Duarte, C.B.; Oliveira, C.R., Journal of Neurochemistry. 1153 - 1163. 3. 67. 1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029801193&partnerID=MN8TOARS . Journal of Neurochemistry

Intracellular free Na<sup>+</sup> concentration increases in cultured retinal cells under oxidative stress conditions

Agostinho, P.; Duarte, C.B.; Oliveira, C.R., Neuroscience Research. 343 - 351. 4. 25. 1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029770633&partnerID=MN8TOARS . 10.1016/S0168-0102(96)01058-9 . Neuroscience Research

Modulation of N-methyl-d-aspartate receptor activity by oxidative stress conditions in chick retinal cells

Agostinho, P.; Duarte, C.B.; Carvalho, A.P.; Oliveira, C.R., Neuroscience Letters. 193 - 196. 3. 198. 1995. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028973020&partnerID=MN8TOARS . Neuroscience Letters

Influence of oxidative stress on membrane potential and on K+ channels in neuronal cells

Agostinho, P.; Duarte, C.B.; Oliveira, C.R., Bioelectrochemistry and Bioenergetics. 297 - 305. 2. 38. 1995. http://www.scopus.com/inward/record.url?eid=2-s2.0-0343743141&partnerID=MN8TOARS . 10.1016/0302-4598(95)01850-E . Bioelectrochemistry and Bioenergetics

Effect of oxidative stress on the release of [<sup>3</sup>H]GABA in cultured chick retina cells

Agostinho, P.; Duarte, C.B.; Carvalho, A.P.; Oliveira, C.R., Brain Research. 213 - 221. 1-2. 655. 1994. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027931845&partnerID=MN8TOARS . 10.1016/0006-8993(94)91616-0 . Brain Research

Survival of allochthonous bacteria in still mineral water bottled in polyvinyl chloride (PVC) and glass

Moreira, L.; Agostinho, P.; Vasconcellos, P.; Morais, V.; Da Costa, M.S., Journal of Applied Bacteriology. 334 - 339. 3. 77. 1994. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027953776&partnerID=MN8TOARS . Journal of Applied Bacteriology

Reactive oxygen species on GABA release

Oliveira, C.R.; Agostinho, P.; Caseiro, P.; Duarte, C.B.; Carvalho, A.P., Annals of the New York Academy of Sciences. 130 - 140. 738. 1994. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028609848&partnerID=MN8TOARS . Annals of the New York Academy of Sciences

All projects

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Information of exclusive responsibility of the researcher 21-11-2021 , from platform CIÊNCIAVITAE.

2019/10/01 - 2021/09/30

Adenosine A2A receptors as a new opportunity to manage and detail the neurobiology of emotional distress

La Caixa HR17-00523

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: LaCaixa Foundation

2018/07/01 - 2021/06/30

Adenosine A2A receptors as triggers of memory dysfunction in Alzheimer's disease: mechanisms and therapeutic prospects

PTDC/MED-NEU/31274/2017

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2016/05 - 2019/10

Role of astrocytes on the control of memory-focus on adenosine A2A receptors

PTDC/NEU-NMC/4154/2014

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Ministério da Ciência, Tecnologia e Ensino Superior

2013/07 - 2015/11

Transcriptome, epigenome and proteome dysregulation in human circuits regulating reward, fear, and habit learning

DARPA-BAA-10-55

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Defense Advanced Research Projects Agency Defense Sciences Office

2012/04 - 2014/09

Role of accumbens and amygdala in the control of chronic stress neuropathology

Provided by PTCRIS: 122254

Funders: Fundação para a Ciência e a Tecnologia, I.P.

2012/05 - 2014/08

Physiopathological role of ecto-5`-nucleotidase - a new target for neuroprotection

122005

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia, I.P.

2011/08 - 2013/12

Localization and metabolism of APP controlling synaptic degeneration in animal models of Alzheimer's disease

114810

Funders: Fundação para a Ciência e a Tecnologia, I.P.

2010/03 - 2012/09

Role of ATP and its P2Y1 receptors in neuroprotection

Provided by PTCRIS: 100423

Funders: Fundação para a Ciência e a Tecnologia, I.P.

2010/04 - 2014/11

New treatments for stress-induced dysregulation of circuits regulating reward, fear, and habit learning

DARPA-BAA-009-68

Funders: Defense Advanced Research Projects Agency Defense Sciences Office

2010/03 - 2012/02

Role of adenosine A2A receptors in microglia and glutamatergic synapses in the control of synaptic plasticity and brain damage

108668

Funders: Fundação para a Ciência e a Tecnologia, I.P.

2007/08 - 2011/07

Design, synthesis and biological assessment of multifunctional compounds as anti-Alzheimer drugs

Provided by PTCRIS: 64151

Funders: Fundação para a Ciência e a Tecnologia, I.P.

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