Rui Nobre

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Researcher

Publications

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Information about journal articles, updated at 26-06-2022, from platform CIÊNCIAVITAE.

Cerebellar morphometric and spectroscopic biomarkers for Machado-Joseph Disease

Nobre, Rui Jorge; Miranda C; Paiva VH; Duarte JV; Castelhano J; Petrella L; Sereno J; et al, Acta Neuropathologica communications . 2022. https://www.doi.org/10.1186/s40478-022-01329-4 . in press Acta Neuropathologica communications

Highly Specific Blood-Brain Barrier Transmigrating Single-Domain Antibodies Selected by an In Vivo Phage Display Screening

Aguiar, Sandra Isabel; Dias, Joana N. R.; André, Ana Santos; Silva, Marta Lisete; Martins, Diana; Carrapiço, Belmira; Castanho, Miguel; et al, Pharmaceutics. 10. 13. 2021. http://dx.doi.org/10.3390/pharmaceutics13101598 . 10.3390/pharmaceutics13101598 . Pharmaceutics

MiRNA-Mediated Knockdown of ATXN3 Alleviates Molecular Disease Hallmarks in a Mouse Model for Spinocerebellar Ataxia Type 3

Nobre, Rui Jorge; Lobo, Diana D.; Henriques, Carina; Duarte, Sonia P.; Lopes, Sara M.; Silva, Ana C.; Lopes, Miguel M.; et al, Nucleic Acid Therapeutics. 2021. http://dx.doi.org/10.1089/nat.2021.0020 . 10.1089/nat.2021.0020 . Nucleic Acid Therapeutics

Autophagy in Spinocerebellar ataxia type 2, a dysregulated pathway and a target for therapy

Marcelo, Adriana; Rosa, Ana; Alves-Cruzeiro, João; Ferreira, Benedita; Reis, Ricardo; Afonso, Inês; Henriques, Carina; et al, 2021. under revision

The blood-brain barrier is disrupted in Machado-Joseph disease/spinocerebellar ataxia type 3: evidence from transgenic mice and human post-mortem samples

Nobre, Rui Jorge; Duarte Lobo, Diana; Oliveira Miranda, Catarina; Pereira, Dina; Castelhano, João; Sereno, José; Koeppen, Arnulf; Castelo-Branco, Miguel; Pereira de Almeida, Luís, Acta Neuropathologica Communications. 1. 8. 2020. http://dx.doi.org/10.1186/s40478-020-00955-0 . 10.1186/s40478-020-00955-0 . Acta Neuropathologica Communications

Simple and Fast SEC-Based Protocol to Isolate Human Plasma-Derived Extracellular Vesicles for Transcriptional Research

Gaspar, Laetitia S.; Santana, Magda M.; Henriques, Carina; Pinto, Maria M.; Ribeiro-Rodrigues, Teresa M.; Girão, Henrique; Nobre, Rui Jorge; Pereira de Almeida, Luís, Molecular Therapy - Methods & Clinical Development. 723 - 737. 18. 2020. http://dx.doi.org/10.1016/j.omtm.2020.07.012 . 10.1016/j.omtm.2020.07.012 . Molecular Therapy - Methods & Clinical Development

Protocol for the Characterization of the CAG Tract and Flanking Polymorphisms in Machado-Joseph Disease: Impact on Diagnosis and Development of Gene-Based Therapies

Lopes, Sara Monteiro; Faro, Rosário; Lopes, Miguel Monteiro; Onofre, Isabel; Mendonça, Nuno; Ribeiro, Joana; Januário, Cristina; Nobre, Rui Jorge; Pereira de Almeida, Luís, The Journal of Molecular Diagnostics. 2020. http://dx.doi.org/10.1016/j.jmoldx.2020.03.003 . 10.1016/j.jmoldx.2020.03.003 . published The Journal of Molecular Diagnostics

Trehalose alleviates the phenotype of Machado–Joseph disease mouse models

Santana, Magda M.; Paixão, Susana; Cunha-Santos, Janete; Silva, Teresa Pereira; Trevino-Garcia, Allyson; Gaspar, Laetitia S.; Nóbrega, Clévio; et al, Journal of Translational Medicine. 1. 18. 2020. http://dx.doi.org/10.1186/s12967-020-02302-2 . 10.1186/s12967-020-02302-2 . Journal of Translational Medicine

Repeated Mesenchymal Stromal Cell Treatment Sustainably Alleviates Machado-Joseph Disease

Oliveira Miranda, Catarina; Marcelo, Adriana; Silva, Teresa Pereira; Barata, João; Vasconcelos-Ferreira, Ana; Pereira, Dina; Nóbrega, Clévio; et al, Molecular Therapy. 2131 - 2151. 9. 26. 2018. http://dx.doi.org/10.1016/j.ymthe.2018.07.007 . 10.1016/j.ymthe.2018.07.007 . published Molecular Therapy

Hypoxia mimetic induces lipid accumulation through mitochondrial dysfunction and stimulates autophagy in murine preadipocyte cell line

Marques, Ana Patrícia; Rosmaninho-Salgado, Joana; Estrada, Marta; Cortez, Vera; Nobre, Rui Jorge; Cavadas, Cláudia, Biochimica et Biophysica Acta (BBA) - General Subjects. 673 - 682. 3. 1861. 2017. http://dx.doi.org/10.1016/j.bbagen.2016.12.005 . 10.1016/j.bbagen.2016.12.005 . published Biochimica et Biophysica Acta (BBA) - General Subjects

Fibroblasts of Machado Joseph Disease patients reveal autophagy impairment

Onofre, Isabel; Mendonça, Nuno; Lopes, Sara; Nobre, Rui; de Melo, Joana Barbosa; Carreira, Isabel Marques; Januário, Cristina; Gonçalves, António Freire; de Almeida, Luis Pereira, Scientific Reports. 1. 6. 2016. http://dx.doi.org/10.1038/srep28220 . 10.1038/srep28220 . published Scientific Reports

Gephyrin Cleavage in In Vitro Brain Ischemia Decreases GABAA Receptor Clustering and Contributes to Neuronal Death

Costa, João T.; Mele, Miranda; Baptista, Márcio S.; Gomes, João R.; Ruscher, Karsten; Nobre, Rui J.; de Almeida, Luís Pereira; Wieloch, Tadeusz; Duarte, Carlos B., Molecular Neurobiology. 3513 - 3527. 6. 53. 2015. http://dx.doi.org/10.1007/s12035-015-9283-2 . 10.1007/s12035-015-9283-2 . published Molecular Neurobiology

Stimulation of Neural Stem Cell Proliferation by Inhibition of Phosphodiesterase 5

Santos, Ana I.; Carreira, Bruno P.; Nobre, Rui J.; Carvalho, Caetana M.; Araújo, Inês M., Stem Cells International. 1 - 13. 2014. 2014. http://dx.doi.org/10.1155/2014/878397 . 10.1155/2014/878397 . published Stem Cells International

Calpain inhibition reduces ataxin-3 cleavage alleviating neuropathology and motor impairments in mouse models of Machado–Joseph disease

Simões, Ana Teresa; Gonçalves, Nélio; Nobre, Rui Jorge; Duarte, Carlos Bandeira; Pereira de Almeida, Luís, Human Molecular Genetics. 4932 - 4944. 18. 23. 2014. http://dx.doi.org/10.1093/hmg/ddu209 . 10.1093/hmg/ddu209 . published Human Molecular Genetics

Gene Therapy for Parkinsons and Alzheimers Diseases: from the Bench to Clinical Trials

Jorge Nobre, Rui; Pereira de Almeida, Luis, Current Pharmaceutical Design. 3434 - 3445. 31. 17. 2011. http://dx.doi.org/10.2174/138161211798072472 . 10.2174/138161211798072472 . published Current Pharmaceutical Design

Characterization of common and rare human papillomaviruses in Portuguese women by the polymerase chain reaction, restriction fragment length polymorphism and sequencing

Nobre, Rui Jorge; Cruz, Eugénia; Real, Odete; de Almeida, Luís Pereira; Martins, Teresa C., Journal of Medical Virology. 1024 - 1032. 6. 82. 2010. http://dx.doi.org/10.1002/jmv.21756 . 10.1002/jmv.21756 . published Journal of Medical Virology

E7 Oncoprotein of Novel Human Papillomavirus Type 108 Lacking the E6 Gene Induces Dysplasia in Organotypic Keratinocyte Cultures

Nobre, R. J.; Herraez-Hernandez, E.; Fei, J.-W.; Langbein, L.; Kaden, S.; Grone, H.-J.; de Villiers, E.-M., Journal of Virology. 2907 - 2916. 7. 83. 2009. http://dx.doi.org/10.1128/jvi.02490-08 . 10.1128/jvi.02490-08 . published Journal of Virology

Complete genotyping of mucosal human papillomavirus using a restriction fragment length polymorphism analysis and an original typing algorithm

Nobre, Rui Jorge; de Almeida, Luís Pereira; Martins, Teresa C., Journal of Clinical Virology. 13 - 21. 1. 42. 2008. http://dx.doi.org/10.1016/j.jcv.2007.11.021 . 10.1016/j.jcv.2007.11.021 . published Journal of Clinical Virology

All projects

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Information of exclusive responsibility of the researcher 26-06-2022 , from platform CIÊNCIAVITAE.

2020/06/01 - 2020/11/30

Expedited validation and large-scale manufacture of a blowing device for collection with inactivation of samples for detection of SARS-CoV-2

269_596884125

Principal investigator

ViraVector-Unidade de Produção de vetores virais para a transferência de genes; Infogene; Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2020/11/01 - 2025/10/31

Accelerating research & development for advanced therapies

945473

Researcher

Innovative Health Initiative

Funders: European Commission; European Federation of Pharmaceutical Industries and Associations

2019/02 - 2019/09

Targeting ATXN3 for the treatment of Spinocerebellar Ataxia 3 (SCA3) using AAV5 and an artificial microRNA

.

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: uniQure NV

2018/04 -

Targeting mutant ATXN3 for the treatment of Spinocerebellar Ataxia 3 (SCA3) using allele-specific ASOs

.

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Wave Life Sciences

2018/07/01 -

Bloqueio da neurodegenerescência por dispersão de silenciadores génicos

PTDC/BTM-SAL/29716/2017

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Associação para a Inovação e Desenvolvimento da FCT

2018/09 - 2019/06

Exosomes as gene delivery vectors for the treatment of Machado-Joseph disease/Spinocerebellar ataxia type 3

21163

Other

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: AFM-Téléthon

2017/09/01 - 2018/09/05

BrainHealth 2020 - Detecção Precoce, Neuro-modulação e Terapias Avançadas para Neuropatologias

CENTRO-01-0145-FEDER-000008

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Centro 2020

2017 -

Tackling CANcer STEM CELIs: a chanllenge anda n opportunity to advance in anti-cancer therapy

SAICTPAC/0022/2015

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Associação para a Inovação e Desenvolvimento da FCT

2016/04/01 -

Gene repair and repression strategies to alleviate Machado-Joseph disease

PTDC/NEU-NMC/0084/2014

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Associação para a Inovação e Desenvolvimento da FCT

2016/06/01 -

Visualização da terapia génica do sistema nervoso central

PTDC/BBB-NAN/0932/2014

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Associação para a Inovação e Desenvolvimento da FCT

2013/03 - 2014/04

Silencing Machado-Joseph Disease through the systemic route

125367

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Associação para a Inovação e Desenvolvimento da FCT

2012 - 2016

Dissecting the pathogenesis of Machado-Joseph disease in a new human disease model derived from induced pluripotent stem cells

116512

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Associação para a Inovação e Desenvolvimento da FCT

2010 - 2017/08/31

Silencing Machado-Joseph disease trough the systemic route

SFRH/BPD/66705/2009

Post-doc Fellow

Funders: Associação para a Inovação e Desenvolvimento da FCT

2010/04 - 2010/09

HPV home-kit – self-collection kit for HPV detection and other STD agents

.

Principal investigator

Infogene

Funders: Quadro de Referência Estratégica Nacional - QREN; Fundo Europeu de Desenvolvimento Regional

2008/10 - 2010/03

Desenvolvimento e validação clínica de um Kit de auto-colheita de células do colo do útero para rastreio do Papilomavírus Humano – HPV

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Other

Funders: Banco Espírito Santo e Comercial de Lisboa

2005/01 - 2006/03

Análise de Alterações Moleculares Relevantes para a Carcinogénese e Tratamento dos Tumores do Estroma Gastrointestinal

.

Researcher

Laboratório de Patologia Molecular do Centro Regional de Oncologia de Coimbra

Funders: Novartis Oncology

2005/01 - 2006/03

Análise de Alterações Moleculares Relevantes para a Carcinogénese e Tratamento dos Tumores do Estroma Gastrointestinal

.

Researcher

Laboratório de Patologia Molecular do Centro Regional de Oncologia de Coimbra

Funders: Novartis Oncology

2004 - 2008

Unravelling the role of human papillomavirus in the development of cervical cancer: new phylogenetic perspective and new pathogenic concepts

SFRH/BD/19165/2004

PhD Student Fellow

Funders: Associação para a Inovação e Desenvolvimento da FCT

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