Susana Isabel Elias Alarico

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Researcher

Overview

Graduation in Biology from the University of Aveiro (Portugal), Master degree in Cell Biology (2003) and PhD in Biology (specialty in Microbiology, 2009) from FCTUC, University of Coimbra (Portugal). Since 2019, PhD Researcher at Center for Neuroscience and Cell Biology, University of Coimbra (CNC/UC). Formerly, a six-year postdoc fellow initiated on April 2009, focused on mycobacterial biosynthetic pathways as potential targets for new anti-tuberculosis therapies and a three-years postdoc fellow initiated on October 2015, focused on nontuberculous mycobacteria as emergent opportunistic pathogens and on the microbiome impact for human health. Co-author in 27 publications: 26 papers in International Peer Review Journals (10 as first author), 1 Book Chapter in ¿Marine enzymes for biocatalysis¿ and 2 papers in Journals of International Scientific Meetings (conference papers). (Scopus Author ID: 8368537600: h-index of 12, total citations 311 by 225 documents). Since 2002, participated in 3 research projects with international funding and in 13 projects with national financial support. Team member of 2 awarded scientific research projects: Prémio Neurociências Mantero Belard 2016, Santa Casa da Misericórdia de Lisboa and Prémio Thomé Villar/Boehringer Ingelheim 2017, Portuguese Society of Pneumology. Supervision and co-supervision of graduation projects, master and PhD national and foreign students and mentorship of StartUp Voucher projects (IAPMEI). Since 2011, Invited Professor at Escola Superior de Enfermagem de Coimbra (Curricular Unit of Microbiology and Parasitology) and collaborator with Instituto de Educação e Cidadania (IEC, Mamarrosa) as volunteer, teaching Experimental Advance Courses on Microbiology. Awarded Projects: PROTOTRANSFER, INESPO III 2018 - FEDER, 2014-2020 POCTEP; ARRISCA C 2018 (Business Idea Typology - Honorable mention); EIT Health Innostars Award 2019 and Caixa Impulse 2019. Member of the multidisciplinary and volunteer team of the Scientific Communication project - ICATE (certificated by PEA UNESCO) that promotes basic education for health for all, to combat HIV/AIDS, malaria and tuberculosis spread in compliance with Goals of UN 2030 Agenda for Sustainable Development. ICATE is coordinate by the non-profit Association AWISHE ¿ Assoc. for World Innovation in Science and Health Education. ICATE counts with pedagogical publications (manuals, digital apps and other didactic materials) in Copyright and ISBN process and with oral communications in National and International Meetings and Conferences.

Affiliation

CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal

Publications

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Information about journal articles, updated at 28-11-2021, from platform CIÊNCIAVITAE.

Improved diabetic wound healing by bovine lactoferricin is associated with relevant changes in the skin immune response and microbiota

MV Mouritzen; Petkovic, Marija; K Qvist; SS Poulsen; Alarico, Susana; Leal, EC; LT Dalgaard; et al, Molecular Therapy - Methods & Clinical Development . 2021. accepted Molecular Therapy - Methods & Clinical Development

A genuine mycobacterial thermophile: Mycobacterium hassiacum growth, survival and GpgS stability at near-pasteurization temperatures

Susana Alarico; Daniela Nunes-Costa; Alexandra Silva; Mafalda Costa; Sandra Macedo-Ribeiro; Nuno Empadinhas, Microbiology. 474 - 483. 166. 2020. https://doi.org/10.1099/mic.0.000898 . 10.1099/mic.0.000898 . published Microbiology

Studies of antimicrobial resistance in rare mycobacteria from a nosocomial environment

Pereira, S.G.; Alarico, S.; Tiago, I.; Reis, D.; Nunes-Costa, D.; Cardoso, O.; Maranha, A.; Empadinhas, N., BMC Microbiology. 1. 19. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85063152478&partnerID=MN8TOARS . 10.1186/s12866-019-1428-4 . published BMC Microbiology

High-quality draft genome sequences of rare nontuberculous mycobacteria isolated from surfaces of a hospital

Tiago, I.; Alarico, S.; Maranha, A.; Coelho, C.; Pereira, S.G.; Empadinhas, N., Microbiology Resource Announcements. 21. 8. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85067244749&partnerID=MN8TOARS . 10.1128/MRA.00496-19 . published Microbiology Resource Announcements

The structural characterization of a glucosylglycerate hydrolase provides insights into the molecular mechanism of mycobacterial recovery from nitrogen starvation

Tatiana Barros Cereija; Susana Alarico; Eva C. Lourenço; José António Manso; M. Rita Ventura; Nuno Empadinhas; Sandra Macedo-Ribeiro; Pedro José Barbosa Pereira, IUCrJ. 572 - 585. 4. 6. 2019. https://doi.org/10.1107/S2052252519005372 . 10.1107/S2052252519005372 . published IUCrJ

Are nurses uniforms a reservoir for Methicillin-resistant Staphylococcus aureus? Lessons to be learned from Portugal

Fernandes, E.; Costa, P.; Graveto, J.; Santos, C.; Osório, N.; Alarico, S.; Albano, H.; Oliveira, V.; Ferreira, S., International Journal of Infectious Diseases. 260 - 261. 73. 2018. http://dx.doi.org/10.1016/j.ijid.2018.04.4008 . 10.1016/j.ijid.2018.04.4008 . published International Journal of Infectious Diseases

Hand hygiene management among nurses: collective health challenges

Graveto, J.M.; Santos, C.; Costa, P.S.; Fernandes, E.; Alarico, S.; Osório, N.; Albano, H.; Oliveira, V., Revista brasileira de enfermagem. 562 - 567. 71. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85054031940&partnerID=MN8TOARS . 10.1590/0034-7167-2017-0538 . published Revista brasileira de enfermagem

Methicillin-resistant Staphylococcus aureus spreading through medical devices used in nursing care: what can we learn from Portugal?

Costa, P.; Graveto, J.; Santos, C.; Fernandes, E.; Albano, H.; Osório, N.; Alarico, S.; Oliveira, V.; Ferreira, S., International Journal of Infectious Diseases. 292 - 293. 73. 2018. http://dx.doi.org/10.1016/j.ijid.2018.04.4081 . 10.1016/j.ijid.2018.04.4081 . published International Journal of Infectious Diseases

ICATE: infection control awareness through education

Soares, R.; Carvalho, A.; Roxo, I.; Lourenço, P.; Ferreira, P.; Marques, R.; Alarico, S.; Ferreira, S., International Journal of Infectious Diseases. 73. 2018. http://dx.doi.org/10.1016/j.ijid.2018.04.3817 . 10.1016/j.ijid.2018.04.3817 . published International Journal of Infectious Diseases

Production, crystallization and structure determination of a mycobacterial glucosylglycerate hydrolase

Cereija, T.B.; Alarico, S.; Empadinhas, N.; Pereira, P.J.B., Acta Crystallographica Section:F Structural Biology Communications. 536 - 540. 9. 73. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85028856991&partnerID=MN8TOARS . 10.1107/S2053230X17012419 . published Acta Crystallographica Section:F Structural Biology Communications

Hospital microbial surface colonization revealed during monitoring of Klebsiella spp., Pseudomonas aeruginosa, and non-tuberculous mycobacteria

Geadas Farias, P.; Gama, F.; Reis, D.; Alarico, S.; Empadinhas, N.; Martins, J.C.; de Almeida, A.F.; Morais, P.V., Antonie van Leeuwenhoek, International Journal of General and Molecular Microbiology. 1 - 14. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85015912782&partnerID=MN8TOARS . 10.1007/s10482-017-0857-z . published Antonie van Leeuwenhoek, International Journal of General and Molecular Microbiology

Glucosylglycerate metabolism, bioversatility and mycobacterial survival

Nunes-Costa, D.; Maranha, A.; Costa, M.; Alarico, S.; Empadinhas, N., Glycobiology. 213 - 227. 3. 27. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85015842532&partnerID=MN8TOARS . 10.1093/glycob/cww132 . Glycobiology

The looming tide of nontuberculous mycobacterial infections in Portugal and Brazil

Nunes-Costa, D.; Alarico, S.; Dalcolmo, M.P.; Correia-Neves, M.; Empadinhas, N., Tuberculosis. 107 - 119. 96. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84954422186&partnerID=MN8TOARS . 10.1016/j.tube.2015.09.006 . published Tuberculosis

Molecular details of sugar biosynthesis in mycobacteria

Fraga, Joana; Silva, Alexandra; Maranha, Ana; Mendes, Vitor; Alarico, Susana; Empadinhas, Nuno; Pereira, Pedro; Macedo-Ribeiro, Sandra, Acta Crystallographica Section A Foundations and Advances. C1659 - C1659. a1. 70. 2014. http://dx.doi.org/10.1107/s2053273314083405 . 10.1107/s2053273314083405 . Acta Crystallographica Section A Foundations and Advances

The molecular biology of mycobacterial trehalose in the quest for advanced tuberculosis therapies

Nobre, A.; Alarico, S.; Maranha, A.; Mendes, V.; Empadinhas, N., Microbiology (United Kingdom). 1547 - 1570. PART 8. 160. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84905216311&partnerID=MN8TOARS . 10.1099/mic.0.075895-0 . published Microbiology (United Kingdom)

Mycobacterium hassiacum recovers from nitrogen starvation with up-regulation of a novel glucosylglycerate hydrolase and depletion of the accumulated glucosylglycerate

Alarico, S.; Costa, M.; Sousa, M.S.; Maranha, A.; Lourenço, E.C.; Faria, T.Q.; Ventura, M.R.; Empadinhas, N., Scientific Reports. 4. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84925854243&partnerID=MN8TOARS . 10.1038/srep06766 . published Scientific Reports

A new bacterial hydrolase specific for the compatible solutes a-d-mannopyranosyl-(1¿2)-d-glycerate and a-d-glucopyranosyl-(1¿2)-d-glycerate

Alarico, S.; Empadinhas, N.; da Costa, M.S., Enzyme and Microbial Technology. 77 - 83. 2. 52. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84871684186&partnerID=MN8TOARS . 10.1016/j.enzmictec.2012.10.008 . published Enzyme and Microbial Technology

Genome sequence of Mycobacterium hassiacum DSM 44199, a rare source of heat-stable mycobacterial proteins

Tiago, I.; Maranha, A.; Mendes, V.; Alarico, S.; Moynihan, P.J.; Clarke, A.J.; Macedo-Ribeiro, S.; Pereira, P.J.B.; Empadinhas, N., Journal of Bacteriology. 7010 - 7011. 24. 194. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870688429&partnerID=MN8TOARS . 10.1128/JB.01880-12 . published Journal of Bacteriology

Biosynthesis of mycobacterial methylglucose lipopolysaccharides

Mendes, V.; Maranha, A.; Alarico, S.; Empadinhas, N., Natural Product Reports. 834 - 844. 8. 29. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863933998&partnerID=MN8TOARS . 10.1039/c2np20014g . published Natural Product Reports

Mycobacterium tuberculosis Rv2419c, the missing glucosyl-3-phosphoglycerate phosphatase for the second step in methylglucose lipopolysaccharide biosynthesis

Mendes, V.; Maranha, A.; Alarico, S.; Da Costa, M.S.; Empadinhas, N., Scientific Reports. 1. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859749065&partnerID=MN8TOARS . 10.1038/srep00177 . published Scientific Reports

A unique combination of genetic systems for the synthesis of trehalose in Rubrobacter xylanophilus: Properties of a rare actinobacterial TreT

Nobre, A.; Alarico, S.; Fernandes, C.; Empadinhas, N.; Da Costa, M.S., Journal of Bacteriology. 7939 - 7946. 24. 190. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-57349146679&partnerID=MN8TOARS . 10.1128/JB.01055-08 . published Journal of Bacteriology

Molecular and physiological role of the trehalose-hydrolyzing a-glucosidase from Thermus thermophilus HB27

Alarico, S.; Da Costa, M.S.; Empadinhas, N., Journal of Bacteriology. 2298 - 2305. 7. 190. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-41549086172&partnerID=MN8TOARS . 10.1128/JB.01794-07 . published Journal of Bacteriology

Mannosylglycerate is essential for osmotic adjustment in Thermus thermophilus strains HB27 and RQ-1

Alarico, S.; Empadinhas, N.; Mingote, A.; Simões, C.; Santos, M.S.; Da Costa, M.S., Extremophiles. 833 - 840. 6. 11. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-35748948644&partnerID=MN8TOARS . 10.1007/s00792-007-0106-x . published Extremophiles

Trehalose biosynthesis in Thermus thermophilus RQ-1: Biochemical properties of the trehalose-6-phosphate synthase and trehalose-6-phosphate phosphatase

Silva, Z.; Alarico, S.; Da Costa, M.S., Extremophiles. 29 - 36. 1. 9. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-14644419634&partnerID=MN8TOARS . 10.1007/s00792-004-0421-4 . published Extremophiles

Distribution of genes for synthesis of trehalose and mannosylglycerate in Thermus spp. and direct correlation of these genes with halotolerance

Alarico, S.; Empadinhas, N.; Simões, C.; Silva, Z.; Henne, A.; Mingote, A.; Santos, H.; Da Costa, M.S., Applied and Environmental Microbiology. 2460 - 2466. 5. 71. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-18444382346&partnerID=MN8TOARS . 10.1128/AEM.71.5.2460-2466.2005 . published Applied and Environmental Microbiology

Osmotic adaptation of Thermus thermophilus RQ-1: Lesson from a mutant deficient in synthesis of trehalose

Silva, Z.; Alarico, S.; Nobre, A.; Horlacher, R.; Marugg, J.; Boos, W.; Mingote, A.I.; Da Costa, M.S., Journal of Bacteriology. 5943 - 5952. 20. 185. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0141960378&partnerID=MN8TOARS . 10.1128/JB.185.20.5943-5952.2003 . published Journal of Bacteriology

Rubritepida flocculans gen. nov., sp. nov., a new slightly thermophilic member of the a-1 subclass of the Proteobacteria

Alarico, S.; Rainey, F.A.; Empadinhas, N.; Schumann, P.; Nobre, M.F.; Da Costa, M.S., Systematic and Applied Microbiology. 198 - 206. 2. 25. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036671222&partnerID=MN8TOARS . published Systematic and Applied Microbiology

All projects

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Information of exclusive responsibility of the researcher 28-11-2021 , from platform CIÊNCIAVITAE.

2022/01/01 - 2025

Nontuberculous mycobacteria from drinking water: beyond the lung disease epidemic

PTDC/BIA-MIC/0122/2021

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2021 - 2024

STOPD - The Gut-Immune-Brain Axis in Parkinson disease

PTDC/MED-NEU/3644/2020

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2020/10/01 -

Sustainable and dual function polymeric edible films: a probiotic and antioxidant delivery food packaging system

PT0038.J.04 - Projeto COVID - Edible Films

Researcher

Universidade de Coimbra Departamento de Engenharia Quimica

Funders: Universidade de Coimbra - Banco Santander

2018 - 2019

PROTOTRANSFER - Projeto INESPO III

2014-2020 POCTEP

Funders: University of Coimbra, FEDER, 2014-2020 POCTEP

2018/07 -

STERILAEROGEL: Green method to prepare sterilized biopolymers based aerogel

POCI-01-0145-FEDER-032625

Researcher

Funders: Fundação para a Ciência e a Tecnologia

2018 - 2019

PROTOTRANSFER - Projeto INESPO III

2014-2020 POCTEP

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: University of Coimbra, FEDER, 2014-2020 POCTEP

2017 - 2019

Microcare - Microbiome of diabetic ulcers: early diagnosis, prognosis and therapy

FIS-FIS-2015-01_DIA_20150630-144

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundo para a Investigação em Saúde, INFARMED

2015 - 2018

Defining the missing links in mycobacterial methylglucose lipopolysaccharide biosynthesis

SFRH/BPD/108299/2015

Post-doc Fellow

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2014 - 2015

Produção e comercialização global de compostos microbianos essenciais para investigação

INOV.C - Mais Centro / CCDRC

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Comissão de Coordenação e Desenvolvimento Regional do Centro

2013/07 - 2015/06

Ambiguity and virulence in a human pathogen

125271

Researcher

Instituto de Biologia Molecular e Celular - IBMC, Instituto para a Investigação e Inovação em Saúde - i3S

Funders: Fundação para a Ciência e a Tecnologia, I.P.

2013/05 - 2015/04

Bioprospecting metagenome from Porcellio dilatatus (Crustacea,Isopoda) guts for plant biomass hydrolytic enzymes

130318

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia, I.P.

2013/07 - 2015/06

Biosynthesis of rare methylmannose polysaccharides in nontuberculous mycobacteria

128742

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia, I.P.

2012 - 2013

“Unravelling the early steps in the biosynthesis of the mycobacterial MGLP”

Ref 120123

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Mizutani Foundation for Glycoscience

2012 - 2015

The early steps in methylglucose lipopolysaccharide biosynthesis in mycobacteria

SFRH/BPD/43321/2008

Post-doc Fellow

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2011/04 - 2013/09

The enigmatic mycobacterial maltokinase

Provided by PTCRIS: 112459

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia, I.P.

2011/01 - 2014/06

Pathway for the synthesis of the mycobacterial MGLP. Biochemical and structural characterization of the key enzymes

Provided by PTCRIS: 110523

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia, I.P.

2009 - 2012

DECIPHERING THE REGULATORY MECHANISMS CONTROLLING COMPATIBLE SOLUTES BIOSYNTHESIS IN THERMUS THERMOPHILUS OSMO- AND THERMOADAPTATION

info:eu-repo/grantAgreement/FCT/SFRH/SFRH2%FBPD2%F433212%F2008/PT

Post-doc Fellow

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2008 - 2010

Cloning, expression and regulation of genes for the synthesis of compatible solutes in Thermus thermophilus

Acção Nº E-9/08

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Conselho de Reitores das Universidades Portuguesas, Portugal

2005/01 - 2008/04

Nature´s shields to environmental stress. Biosynthesis of compatible solutes in extremely radiation-resistant Rubrobacter spp.

Provided by PTCRIS: 56511

Other

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia, I.P.

2004 - 2008

PhD Thesis: Relevance of mannosylglycerate and trehalose accumulation in the osmoadaptation of Thermus thermophilus

SFRH/BD/14140/2003

PhD Student Fellow

Universidade de Coimbra Centro de Neurociências e Biologia Celular

2004 - 2006

“Hotsolutes - New applications of compatible solutes from hyperthermophiles”

CRAFT, COOP-CT-2003-508644

Other

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: European Commission Sixth Framework Programme

2002 - 2005

“Hypersolutes - Exploiting new solutes from hyperthermophiles for the preservation of biomaterials: cell factories for production of hypersolutes”

QLK3-CT-2000-00640

Other

Funders: European Commission Sixth Framework Programme

2002 - 2003

EXTREMELY GAMMA RADIATION-RESISTANT BACTERIA: TAXONOMY, DIVERSITY AND PHYSIOLOGY

POCTI/BSE/35029/99

Research Technician Fellow

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2001 - 2002

Exploração de solutos de organismos hipertermofílicos com vista à sua utilização como estabilizantes de enzimas

PRAXIS/P/BIO/12 082/1998

Research Technician Fellow

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2001 - 2002

Exploração de solutos de organismos hipertermofílicos com vista à sua utilização como estabilizantes de enzimas

PRAXIS/P/BIO/12 082/1998

Research Technician Fellow

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

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