Innovative Therapies

Advanced Therapies Group

Ageing

Cardiovascular Diseases

Stem Cells

iPSCs Differentiation

Nanomaterials


Research lines

Disease modeling and drug screening programs based on stem cell-based models

Nanomedicine program to modulate the activity of stem cells and their progenies

Overview

The research group of biomaterials and stem cell-based therapeutics was created in January 2008 at CNC. The research group aims at generating fundamental and translational knowledge in the intersection of biomaterials with stem cells. The research group has two main avenues of research:

  1. Disease modeling and drug screening program: in vitro cell/tissue models from human stem cells. Stem cells, in particular induced pluripotent stem cells (iPSCs), may be an excellent source of cells for disease modeling and drug discovery programs related to cardiovascular diseases. The potential of iPSCs to generate disease models led to the creation of several biobanks in USA (Coriell Institute for Medical Research, NIH Center for Regenerative Medicine, ATCC and University owned biobanks), Europe (Cellartis; and an European initiative of Stem cell biobank) and Japan (RIKEN bioresource center) for storage and distribution of iPSC lines originated from patients and healthy controls. In the last 6 years my research group has developed several tissue models from stem cells that may be an important platform for drug discovery programs related to cardiovascular diseases. A particular interest of the group is to develop biomaterials and bioengineering platforms for the efficient maturation/specification of stem cells and their progenies. The research group uses many tools to accomplish this goal, including the design of new biomaterials with relevant biological information, molecular and cell biology, microfluidic systems, high content analysis, and animal experimentation.
  2. Nanomedicine platforms to modulate the activity of stem cells and their progenies. The development of a wide spectrum of nanotechnologies (referred as Nanomedicine by National Institutes of Health for applications in the biomedical area) during the last years are very promising for the study of stem cell biology and to control exogenous and endogenous stem cells for regenerative medicine. Our group is particularly interested to use these tools to induce in vivo stem cell differentiation and to mobilize stem cells from their niches to treat cardiovascular diseases. For this purpose, we are developing nanomaterials that release efficiently biomolecules (small molecules, proteins or non-coding RNAs) to manipulate stem cells or their progenies.

More information about this research group here.

Team

Former members

Publications

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Information about journal articles, updated at 17-12-2023, from platform CIÊNCIAVITAE.

Cellular reprogramming as a tool to model human aging in a dish

Patricia R. Pitrez; Luis M. Monteiro; Oliver Borgogno; Xavier Nissan; Jerome Mertens; Lino Ferreira, 2024. Nature Communications. 2024. https://doi.org/10.1038/s41467-024-46004-5 . 10.1038/s41467-024-46004-5 . Nature Communications

Remodeling of the Cardiac Extracellular Matrix Proteome During Chronological and Pathological Aging

Santinha, Deolinda; Vilaça, Andreia; Estronca, Luís; Schüler, Svenja C.; Bartoli, Catherine; De Sandre-Giovannoli, Annachiara; Figueiredo, Arnaldo; et al, 2024. Mol Cell Proteomics. 1. 23. 2024. 10.1016/j.mcpro.2023.100706 . published Mol Cell Proteomics

Reconstruction of cell-specific models capturing the influence of metabolism on DNA methylation in cancer

Tânia Barata; Vítor Pereira; Ricardo Pires das Neves; Miguel Rocha, 2024. Computers in Biology and Medicine. 2024. https://doi.org/10.1016/j.compbiomed.2024.108052 . 10.1016/j.compbiomed.2024.108052 . Computers in Biology and Medicine

POSEIDON: Peptidic Objects SEquence-based Interaction with cellular DOmaiNs: a new database and predictor

Preto, António J.; Caniceiro, Ana B.; Duarte, Francisco; Fernandes, Hugo; Ferreira, Lino; Mourão, Joana; Moreira, Irina S., 2024. Journal of Cheminformatics. 1. 16. 2024. http://dx.doi.org/10.1186/s13321-024-00810-7 . 10.1186/s13321-024-00810-7 . Journal of Cheminformatics

Nanoparticle-encapsulated retinoic acid for the modulation of bone marrow hematopoietic stem cell niche

Emanuel Quartin; Susana Rosa; Sara Gonzalez-Anton; Laura Mosteo Lopez; Vitor Francisco; Delfim Duarte; Cristina Lo Celso; Ricardo Pires das Neves; Lino Ferreira, 2024. Bioactive Materials. 2024. https://doi.org/10.1016/j.bioactmat.2023.12.017 . 10.1016/j.bioactmat.2023.12.017 . Bioactive Materials

Near-Infrared Light Activated Formulation for the Spatially Controlled Release of CRISPR-Cas9 Ribonucleoprotein for Brain Gene Editing

Simões, Susana; Lino, Miguel; Barrera, Angela; Rebelo, Catarina; Tomatis, Francesca; Vilaça, Andreia; Breunig, Christopher; et al, 2024. Angewandte Chemie International Edition. 2024. http://dx.doi.org/10.1002/anie.202401004 . 10.1002/anie.202401004 . Angewandte Chemie International Edition

Nanoparticle-encapsulated retinoic acid for the modulation of bone marrow hematopoietic stem cell niche

Emanuel Quartin; Susana Rosa; Sara Gonzalez-Anton; Laura Mosteo Lopez; Vitor Francisco; Delfim Duarte; Cristina Lo Celso; Ricardo Pires das Neves; Lino Ferreira, 2024. Bioactive Materials. 2024. https://doi.org/10.1016/j.bioactmat.2023.12.017 . 10.1016/j.bioactmat.2023.12.017 . Bioactive Materials

Acidic sophorolipid and antimicrobial peptide based formulation as antimicrobial and antibiofilm agents.

Seena S; Ferrão R; Pala M; Roelants SLKW; Soetaert W; Stevens CV; Ferreira L; Rai A, 2023. Biomaterials advances. 2023. https://doi.org/10.1016/j.bioadv.2023.213299 . 10.1016/j.bioadv.2023.213299 . Biomaterials advances

Protein-Nanoparticle Interactions Govern the Interfacial Behavior of Polymeric Nanogels: Study of Protein Corona Formation at the Air/Water Interface.

Federico Traldi; Liu P; Inês Maria Cunha Albino; Ferreira L; Ali Zarbakhsh; Marina Resmini, 2023. International journal of molecular sciences. 2023. https://europepmc.org/articles/PMC9917661 . 10.3390/ijms24032810 . International journal of molecular sciences

Imaging platforms to dissect the in vivo communication, biodistribution and controlled release of extracellular vesicles

Banerjee, Arnab; Lino, Miguel; Jesus, Carlos; Ribeiro, Quélia; Abrunhosa, Antero; Ferreira, Lino, 2023. Journal of Controlled Release. 549 - 563. 360. 2023. http://dx.doi.org/10.1016/j.jconrel.2023.06.039 . 10.1016/j.jconrel.2023.06.039 . Journal of Controlled Release

Small extracellular vesicles administered directly in the brain promote neuroprotection and decreased microglia reactivity in a stroke mouse model

Lino, Miguel M.; Rondão, Tiago; Banerjee, Arnab; Aires, Inês; Rodrigues, Magda; Reis, Tiago; Santinha, António; et al, 2023. Nanoscale. 18212 - 18217. 45. 15. 2023. http://dx.doi.org/10.1039/d3nr03861k . 10.1039/d3nr03861k . Nanoscale

Designing Cell Delivery Peptides and SARS-CoV-2-Targeting Small Interfering RNAs: A Comprehensive Bioinformatics Study with Generative Adversarial Network-Based Peptide Design and <i>In Vitro</i> Assays

González, Ricardo D.; Simões, Susana; Ferreira, Lino; Carvalho, Alexandra T. P., 2023. Molecular Pharmaceutics. 6079 - 6089. 12. 20. 2023. http://dx.doi.org/10.1021/acs.molpharmaceut.3c00444 . 10.1021/acs.molpharmaceut.3c00444 . Molecular Pharmaceutics

The evolution of blood brain barrier permeability changes after stroke, and its implications on clinical outcome: a systematic review and meta-analysis.

Sara Bernardo-Castro; João André Sousa; Martins E; Helena Donato; Nunes CA; d'Almeida OC; Miguel Castelo-Branco; et al, 2023. International journal of stroke : official journal of the International Stroke Society. 2023. https://doi.org/10.1177/17474930231166306 . 10.1177/17474930231166306 . International journal of stroke : official journal of the International Stroke Society

Retinoic Acid-Loaded Nanoparticles Promote Neurovascular Protection in Stroke.

Marta Pereira; Alba Grayston; Miguel García-Gabilondo; Vitor Francisco; Ana Clara Cristovao; João Pedro Marto; Helena L. A. Vieira; et al, 2023. Stroke. 2023. https://doi.org/10.1161/STROKEAHA.122.041839 . 10.1161/strokeaha.122.041839 . Stroke

Engineering optical tools for remotely controlled brain stimulation and regeneration

Artur Filipe Rodrigues; Catarina Rebelo; Tiago Reis; Susana Simões; Liliana Bernardino; João Peça; Lino Ferreira, 2023. Biomaterials Science. 2023. https://doi.org/10.1039/D2BM02059A . 10.1039/D2BM02059A . Biomaterials Science

Engineering graphene-based electrodes for optical neural stimulation

Artur Filipe Rodrigues; Ana P. M. Tavares; Susana Simões; Rui P. F. F. Silva; Tomás Sobrino; Bruno R. Figueiredo; Goreti Sales; Lino Ferreira, 2023. Nanoscale. 2023. https://doi.org/10.1039/D2NR05256C . 10.1039/D2NR05256C . Nanoscale

Each Cellular Compartment Has a Characteristic Protein Reactive Cysteine Ratio Determining Its Sensitivity to Oxidation

Ricardo Pires das Neves; Mónica Chagoyen; Antonio Martinez-Lorente; Carlos Iñiguez; Ana Calatrava; Juana Calabuig; Francisco J. Iborra, 2023. Antioxidants. 2023. https://doi.org/10.3390/antiox12061274 . 10.3390/antiox12061274 . Antioxidants

Reconsidering the role of blood-brain barrier in Alzheimer's disease: From delivery to target.

Sousa JA; Bernardes C; Bernardo-Castro S; Lino M; Albino I; Ferreira L; Brás J; et al, 2023. Frontiers in aging neuroscience. 2023. https://europepmc.org/articles/PMC9978015 . 10.3389/fnagi.2023.1102809 . Frontiers in aging neuroscience

Author Correction: Efficient spatially targeted gene editing using a near-infrared activatable protein-conjugated nanoparticle for brain applications

Catarina Rebelo; Tiago Reis; Joana Guedes; Cláudia Saraiva; Artur Filipe Rodrigues; Susana Simões; Liliana Bernardino; et al, 2023. Nature Communications. 2023. https://doi.org/10.1038/s41467-023-39976-3 . 10.1038/s41467-023-39976-3 . Nature Communications

A Polymeric Nanoparticle Formulation for Targeted mRNA Delivery to Fibroblasts

Artur Filipe Rodrigues; Catarina Rebelo; Susana Simões; Cristiana Paulo; Sónia Pinho; Vítor Francisco; Lino Ferreira, 2022. Advanced Science. 2022. https://doi.org/10.1002/advs.202205475 . 10.1002/advs.202205475 . Advanced Science

Unraveling the potential of endothelial progenitor cells as a treatment following ischemic stroke.

Custodia A; Ouro A; Sargento-Freitas J; Aramburu-Núñez M; Pías-Peleteiro JM; Pablo Hervella; Rosell A; et al, 2022. Frontiers in neurology. 2022. https://europepmc.org/articles/PMC9492921 . 10.3389/fneur.2022.940682 . Frontiers in neurology

MicroRNA-124-3p-enriched small extracellular vesicles as a therapeutic approach for Parkinson’s disease

2022. Molecular Therapy. 2022. http://dx.doi.org/10.1016/j.ymthe.2022.06.003 . 10.1016/j.ymthe.2022.06.003 . Molecular Therapy

Efficient spatially targeted gene editing using a near-infrared activatable protein-conjugated nanoparticle for brain applications

Catarina Rebelo; Tiago Reis; Joana Guedes; Cláudia Saraiva; Artur Filipe Rodrigues; Susana Simões; Liliana Bernardino; et al, 2022. Nature Communications. 2022. https://doi.org/10.1038/s41467-022-31791-6 . 10.1038/s41467-022-31791-6 . Nature Communications

(Epi)transcriptomics in cardiovascular and neurological complications of COVID-19.

Jusic A; Stellos K; Ferreira L; Baker AH; Devaux Y, 2022. Journal of molecular and cellular cardiology plus. 2022. https://europepmc.org/articles/PMC9330360 . 10.1016/j.jmccpl.2022.100013 . Journal of molecular and cellular cardiology plus

Antimicrobial Peptide-Tether Dressing Able to Enhance Wound Healing by Tissue Contact

Akhilesh Rai; Rafaela Ferrão; Denise Marta; Andreia Vilaça; Miguel Lino; Tiago Rondão; Jian Ji; Artur Paiva; Lino Ferreira, 2022. ACS Applied Materials & Interfaces. 2022. https://doi.org/10.1021/acsami.2c06601 . 10.1021/acsami.2c06601 . ACS Applied Materials & Interfaces

A NIR-II emissive polymer AIEgen for imaging-guided photothermal elimination of bacterial infection

2022. Biomaterials. 121579 - 121579. 286. 2022. http://dx.doi.org/10.1016/j.biomaterials.2022.121579 . 10.1016/j.biomaterials.2022.121579 . Biomaterials

Antimicrobial peptide-based materials: opportunities and challenges

Akhilesh Rai; Rafaela Ferrão; Paulo Palma; Tatiana Patricio; Paula Parreira; Elsa Anes; Chiara Tonda-Turo; et al, 2022. Journal of Materials Chemistry B. 2022. https://doi.org/10.1039/D1TB02617H . 10.1039/D1TB02617H . Journal of Materials Chemistry B

Reconstruction of tissue-specific genome-scale metabolic models for human cancer stem cells

Barata, Tânia; Vieira, Vítor; Rodrigues, Rúben; Neves, Ricardo Pires das; Rocha, Miguel, 2022. Computers in Biology and Medicine. 142. 2022. http://dx.doi.org/10.1016/j.compbiomed.2021.105177 . 10.1016/j.compbiomed.2021.105177 . Computers in Biology and Medicine

Extracellular vesicles enriched with an endothelial cell pro-survival microRNA affects skin tissue regeneration

2022. Molecular Therapy - Nucleic Acids. 307 - 327. 28. 2022. http://dx.doi.org/10.1016/j.omtn.2022.03.018 . 10.1016/j.omtn.2022.03.018 . Molecular Therapy - Nucleic Acids

Multi-parametric surface plasmon resonance-based intake quantification of label-free light-activated nanoparticles by therapeutic limbal stem cells for corneal blindness

2022. Nano Select. 2022. http://dx.doi.org/10.1002/nano.202200027 . 10.1002/nano.202200027 . Nano Select

Intercellular transfer of miR-200c-3p impairs the angiogenic capacity of cardiac endothelial cells

2022. Molecular Therapy. 2257 - 2273. 6. 30. 2022. http://dx.doi.org/10.1016/j.ymthe.2022.03.002 . 10.1016/j.ymthe.2022.03.002 . Molecular Therapy

Strategies and challenges for non-viral delivery of non-coding RNAs to the heart.

Vilaça A; de Windt LJ; Hugo Fernandes; Ferreira L, 2022. Trends in molecular medicine. 2022. https://doi.org/10.1016/j.molmed.2022.10.002 . 10.1016/j.molmed.2022.10.002 . Trends in molecular medicine

Re-Use of Caco-2 Monolayers in Permeability Assays—Validation Regarding Cell Monolayer Integrity

Pires, Cristiana L.; Praça, Catarina; Martins, Patrícia A. T.; Batista de Carvalho, Ana L. M.; Ferreira, Lino; Marques, Maria Paula M.; Moreno, Maria João, 2021. Pharmaceutics. 10. 13. 2021. http://dx.doi.org/10.3390/pharmaceutics13101563 . 10.3390/pharmaceutics13101563 . Pharmaceutics

Human Extracellular-Matrix Functionalization of 3D hiPSC-Based Cardiac Tissues Improves Cardiomyocyte Maturation

Almeida, Henrique V.; Tenreiro, Miguel F.; Louro, Ana F.; Abecasis, Bernardo; Santinha, Deolinda; Calmeiro, Tomás; Fortunato, Elvira; et al, 2021. ACS Applied Bio Materials. 1888 - 1899. 2. 4. 2021. http://dx.doi.org/10.1021/acsabm.0c01490 . 10.1021/acsabm.0c01490 . ACS Applied Bio Materials

Interindividual heterogeneity affects the outcome of human cardiac tissue decellularization

Tenreiro, Miguel F.; Almeida, Henrique V.; Calmeiro, Tomás; Fortunato, Elvira; Ferreira, Lino; Alves, Paula M.; Serra, Margarida, 2021. Scientific Reports. 1. 11. 2021. http://dx.doi.org/10.1038/s41598-021-00226-5 . 10.1038/s41598-021-00226-5 . Scientific Reports

Engineered extracellular vesicles as brain therapeutics

Lino, Miguel M.; Simões, Susana; Tomatis, Francesca; Albino, Inês; Barrera, Angela; Vivien, Denis; Sobrino, Tomas; Ferreira, Lino, 2021. Journal of Controlled Release. 472 - 485. 338. 2021. http://dx.doi.org/10.1016/j.jconrel.2021.08.037 . 10.1016/j.jconrel.2021.08.037 . Journal of Controlled Release

Therapeutic Nanoparticles for the Different Phases of Ischemic Stroke

Bernardo-Castro, Sara; Albino, Inês; Barrera-Sandoval, Ángela María; Tomatis, Francesca; Sousa, João André; Martins, Emanuel; Simões, Susana; et al, 2021. Life. 6. 11. 2021. http://dx.doi.org/10.3390/life11060482 . 10.3390/life11060482 . Life

Exogenous loading of miRNAs into small extracellular vesicles

Abreu, Ricardo C.; Ramos, Cristiana V.; Becher, Clarissa; Lino, Miguel; Jesus, Carlos; Costa Martins, Paula A.; Martins, Patrícia A. T.; et al, 2021. Journal of Extracellular Vesicles. 10. 10. 2021. http://dx.doi.org/10.1002/jev2.12111 . 10.1002/jev2.12111 . Journal of Extracellular Vesicles

Refinement of a differentiation protocol using neuroblastoma SH-SY5Y cells for use in neurotoxicology research

Rui F. Simões; Rafaela Ferrão; Margarida R. Silva; Sonia L.C. Pinho; Lino Ferreira; Paulo J. Oliveira; Teresa Cunha-Oliveira, 2021. Food and Chemical Toxicology. 111967 - 111967. 149. 2021. https://doi.org/10.1016/j.fct.2021.111967 . 10.1016/j.fct.2021.111967 . Food and Chemical Toxicology

Antimicrobial and pro-angiogenic properties of soluble and nanoparticle-immobilized LL37 peptides

Michela Comune; Akhilesh Rai; Paulo Palma; Chiara TondaTuro; Lino Ferreira, 2021. Biomaterials Science. 2021. https://doi.org/10.1039/D1BM01034D . 10.1039/D1BM01034D . Biomaterials Science

High-throughput screening of nanoparticles in drug delivery

Inês Tomé; Vitor Francisco; Hugo Fernandes; Lino Ferreira, 2021. APL Bioengineering. 2021. https://doi.org/10.1063/5.0057204 . 10.1063/5.0057204 . APL Bioengineering

Toxicological Profile of Umbilical Cord Blood-Derived Small Extracellular Vesicles

Rodrigues, Silvia C.; Cardoso, Renato M. S.; Gomes, Claudia F.; Duarte, Filipe V.; Freire, Patricia C.; Neves, Ricardo; Simoes-Correia, Joana, 2021. Membranes. 9. 11. 2021. http://dx.doi.org/10.3390/membranes11090647 . 10.3390/membranes11090647 . Membranes

Biomedical applications of the peptide decorated gold nanoparticles

Rai, Akhilesh; Ferreira, Lino, 2021. Critical Reviews in Biotechnology. 186 - 215. 2. 41. 2021. http://dx.doi.org/10.1080/07388551.2020.1853031 . 10.1080/07388551.2020.1853031 . Critical Reviews in Biotechnology

Induced pluripotent stem cell-derived vascular networks to screen nano–bio interactions

Estronca, Luís; Francisco, Vitor; Pitrez, Patrícia; Honório, Inês; Carvalho, Lara; Vazão, Helena; Blersch, Josephine; et al, 2021. Nanoscale Horizons. 2021. http://dx.doi.org/10.1039/d0nh00550a . 10.1039/d0nh00550a . published Nanoscale Horizons

Immunomodulatory Properties of Umbilical Cord Blood-Derived Small Extracellular Vesicles and Their Therapeutic Potential for Inflammatory Skin Disorders

Sílvia C. Rodrigues; Renato M. S. Cardoso; Patricia C. Freire; Cláudia F. Gomes; Filipe V. Duarte; Ricardo Pires das Neves; Joana Simões-Correia, 2021. International Journal of Molecular Sciences. 2021. https://doi.org/10.3390/ijms22189797 . 10.3390/ijms22189797 . International Journal of Molecular Sciences

Screening for Colorectal Cancer Leading into a New Decade: The “Roaring ‘20s” for Epigenetic Biomarkers?

Almeida-Lousada, Hélder; Mestre, André; Ramalhete, Sara; Price, Aryeh J.; de Mello, Ramon Andrade; Marreiros, Ana D.; Neves, Ricardo Pires das; Castelo-Branco, Pedro, 2021. Current Oncology. 4874 - 4893. 6. 28. 2021. http://dx.doi.org/10.3390/curroncol28060411 . 10.3390/curroncol28060411 . Current Oncology

Identification of colorectal cancer associated biomarkers: an integrated analysis of miRNA expression

Fonseca, André; Ramalhete, Sara Ventura; Mestre, André; Pires das Neves, Ricardo; Marreiros, Ana; Castelo-Branco, Pedro; Roberto, Vânia Palma, 2021. Aging. 21991 - 22029. 18. 13. 2021. http://dx.doi.org/10.18632/aging.203556 . 10.18632/aging.203556 . Aging

Revisiting gene delivery to the brain: silencing and editing

João Conniot; Sepehr Talebian; Susana Simões; Lino Ferreira; João Conde, 2021. Biomaterials Science. 1065 - 1087. 4. 9. 2021. https://doi.org/10.1039/D0BM01278E . 10.1039/D0BM01278E . Biomaterials Science

Development of an optimized and scalable method for isolation of umbilical cord blood-derived small extracellular vesicles for future clinical use

Renato M. S. Cardoso; Silvia C. Rodrigues; Claudia F. Gomes; Filipe V. Duarte; Maryse Romao; Ermelindo C. Leal; Patricia C. Freire; Ricardo Neves; Joana Simões-Correia, 2021. STEM CELLS Translational Medicine. 2021. https://doi.org/10.1002/sctm.20-0376 . 10.1002/sctm.20-0376 . STEM CELLS Translational Medicine

Correction to: In vitro mechanistic studies on a-amanitin and its putative antidotes

Daniela Ferreira Rodrigues; Ricardo Pires das Neves; Alexandra T. P. Carvalho; Maria Lourdes Bastos; Vera M. Costa; Félix Carvalho, 2020. Archives of Toxicology. 2020. https://doi.org/10.1007/s00204-020-02735-0 . 10.1007/s00204-020-02735-0 . Archives of Toxicology

In vitro mechanistic studies on a-amanitin and its putative antidotes

Daniela Ferreira Rodrigues; Ricardo Pires das Neves; Alexandra T. P. Carvalho; Maria Lourdes Bastos; Vera M. Costa; Félix Carvalho, 2020. Archives of Toxicology. 2020. https://doi.org/10.1007/s00204-020-02718-1 . 10.1007/s00204-020-02718-1 . Archives of Toxicology

A high-throughput screening platform to identify nanocarriers for efficient delivery of RNA-based therapies

Francisco, Vitor; Rebelo, Catarina; Rodrigues, Artur Filipe; Blersch, Josephine; Fernandes, Hugo; Ferreira, Lino, 2020. Methods. 2020. http://dx.doi.org/10.1016/j.ymeth.2020.12.002 . 10.1016/j.ymeth.2020.12.002 . Methods

A Light-Triggerable Nanoparticle Library for the Controlled Release of Non-Coding RNAs

Blersch, Josephine; Francisco, Vitor; Rebelo, Catarina; Jiménez-Balsa, Adrian; Antunes, Helena; Gonzato, Carlo; Pinto, Sandra; et al, 2020. Angewandte Chemie International Edition. 1985 - 1991. 5. 59. 2020. http://dx.doi.org/10.1002/anie.201911398 . 10.1002/anie.201911398 . Angewandte Chemie International Edition

Pathophysiology of Blood–Brain Barrier Permeability Throughout the Different Stages of Ischemic Stroke and Its Implication on Hemorrhagic Transformation and Recovery

Bernardo-Castro, Sara; Sousa, João André; Brás, Ana; Cecília, Carla; Rodrigues, Bruno; Almendra, Luciano; Machado, Cristina; et al, 2020. Frontiers in Neurology. 11. 2020. http://dx.doi.org/10.3389/fneur.2020.594672 . 10.3389/fneur.2020.594672 . Frontiers in Neurology

A light-triggerable formulation to control the stability of pro-angiogenic transcription factor hypoxia inducible factor-1a (HIF-1a)

Josephine Blersch; Vitor Francisco; Catarina Rebelo; Adrian Jiménez-Balsa; Helena Antunes; Sandra Pinto; Susana Simões; Akhilesh Rai; Lino Ferreira, 2020. Nanoscale. 2020. https://doi.org/10.1039/C9NR10503D . 10.1039/C9NR10503D . Nanoscale

Native and bioengineered extracellular vesicles for cardiovascular therapeutics.

de Abreu RC; Fernandes H; da Costa Martins PA; Sahoo S; Emanueli C; Ferreira L, 2020. Nature reviews. Cardiology. 2020. http://europepmc.org/abstract/med/32483304 . 10.1038/s41569-020-0389-5 . Nature reviews. Cardiology

Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine

Raquel Ferreira; Joseph Napoli; Tariq Enver; Liliana Bernardino; Lino Ferreira, 2020. Nature Communications. 2020. https://doi.org/10.1038/s41467-020-18042-2 . 10.1038/s41467-020-18042-2 . Nature Communications

Spatially resolved analysis of FFPE tissue proteomes by quantitative mass spectrometry.

Buczak K; Kirkpatrick JM; Truckenmueller F; Santinha D; Ferreira L; Roessler S; Singer S; Beck M; Ori A, 2020. Nature protocols. 2020. http://europepmc.org/abstract/med/32737464 . 10.1038/s41596-020-0356-y . Nature protocols

Permeability of the blood brain barrier through the phases of ischemic stroke and relation with clinical outcome: protocol for a systematic review

Ferreira, Lino, 2020. BMJ Open. 9. 10. 2020. published BMJ Open

Vulnerability of progeroid smooth muscle cells to biomechanical forces is mediated by MMP13.

Pitrez PR; Estronca L; Monteiro LM; Colell G; Vazão H; Santinha D; Harhouri K; et al, 2020. Nature communications. 2020. http://europepmc.org/abstract/med/32807790 . 10.1038/s41467-020-17901-2 . Nature communications

What human blood-brain barrier models can tell us about BBB function and drug discovery?

Ferreira, Lino, 2019. Expert opinion on drug discovery. 2019. https://doi.org/10.1080/17460441.2019.1646722 . 10.1080/17460441.2019.1646722 . Expert opinion on drug discovery

Functional characterization of iPSC-derived arterial- and venous-like endothelial cells

Ferreira, Lino, 2019. Scientific Reports. 2019. http://dx.doi.org/10.1038/s41598-019-40417-9 . 10.1038/s41598-019-40417-9 . Scientific Reports

A High-Throughput Screening Method to Identify Compounds Displaying Human Vascular Embryonic Toxicity

Ferreira, Lino, 2019. Current Protocols in Stem Cell Biology. 2019. http://dx.doi.org/10.1002/cpsc.93 . 10.1002/cpsc.93 . Current Protocols in Stem Cell Biology

Derivation of Brain Capillary-like Endothelial Cells from Human Pluripotent Stem Cell-Derived Endothelial Progenitor Cells.

Ferreira, Lino, 2019. Stem cell reports. 2019. https://europepmc.org/articles/PMC6829749 . 10.1016/j.stemcr.2019.08.002 . Stem cell reports

A light-triggerable nanoparticle library for the controlled release of non-coding RNAs.

Ferreira, Lino, 2019. Angewandte Chemie (International ed. in English). 2019. https://doi.org/10.1002/anie.201911398 . 10.1002/anie.201911398 . Angewandte Chemie (International ed. in English)

A near infrared light-triggerable modular formulation for the delivery of small biomolecules

Ferreira, Lino, 2019. Journal of Nanobiotechnology. 2019. http://dx.doi.org/10.1186/s12951-019-0530-y . 10.1186/s12951-019-0530-y . Journal of Nanobiotechnology

A positron-emission tomography (PET)/magnetic resonance imaging (MRI) platform to track in vivo small extracellular vesicles

Arnab Banerjee; Vitor Alves; Tiago Rondão; José Sereno; Ângela Neves; Miguel Lino; Andreia Ribeiro; Antero J. Abrunhosa; Lino S. Ferreira, 2019. Nanoscale. 13243 - 13248. 28. 11. 2019. https://doi.org/10.1039/C9NR02512J . 10.1039/C9NR02512J . Nanoscale

A photodynamic antibacterial spray-coating based on the host–guest immobilization of the photosensitizer methylene blue

Tian-tian Yao; Jing Wang; Yun-fan Xue; Wei-jiang Yu; Qiang Gao; Lino Ferreira; Ke-Feng Ren; Jian Ji, 2019. Journal of Materials Chemistry B. 2019. https://doi.org/10.1039/C9TB01069F . 10.1039/C9TB01069F . Journal of Materials Chemistry B

Bioprocess decision support tool for scalable manufacture of extracellular vesicles

Ferreira, Lino, 2019. Biotechnology and Bioengineering. 2019. http://dx.doi.org/10.1002/bit.26809 . 10.1002/bit.26809 . Biotechnology and Bioengineering

The Kinetics of Small Extracellular Vesicle Delivery Impacts Skin Tissue Regeneration

Ferreira, Lino, 2019. ACS Nano. 2019. http://dx.doi.org/10.1021/acsnano.9b00376 . 10.1021/acsnano.9b00376 . ACS Nano

Spatially Confining Surface Roughness on Exponentially Growing Polyelectrolyte Multilayer Films

Ferreira, Lino, 2019. Advanced Materials Interfaces. 2019. http://dx.doi.org/10.1002/admi.201900702 . 10.1002/admi.201900702 . Advanced Materials Interfaces

Unveiling the molecular crosstalk in a human induced pluripotent stem cell-derived cardiac model

Bernardo Abecasis; Patrícia Gomes-Alves; Susana Rosa; Pedro J. Gouveia; Lino Ferreira; Margarida Serra; Paula M. Alves, 2019. Biotechnology and Bioengineering. 1245 - 1252. 5. 116. 2019. https://doi.org/10.1002/bit.26929 . 10.1002/bit.26929 . Biotechnology and Bioengineering

Soft culture substrates favor stem-like cellular phenotype and facilitate reprogramming of human mesenchymal stem/stromal cells (hMSCs) through mechanotransduction

Neves, Ricardo, 2019. Scientific Reports. 2019. http://dx.doi.org/10.1038/s41598-019-45352-3 . 10.1038/s41598-019-45352-3 . Scientific Reports

A nanoformulation for the preferential accumulation in adult neurogenic niches

Ferreira, Lino, 2018. Journal of Controlled Release. 2018. http://dx.doi.org/10.1016/j.jconrel.2018.06.013 . 10.1016/j.jconrel.2018.06.013 . Journal of Controlled Release

Intravenous administration of retinoic acid-loaded polymeric nanoparticles prevents ischemic injury in the immature brain

Ferreira, Lino, 2018. Neuroscience Letters. 2018. http://dx.doi.org/10.1016/j.neulet.2018.02.066 . 10.1016/j.neulet.2018.02.066 . Neuroscience Letters

Mitochondrial levels determine variability in cell death by modulating apoptotic gene expression

Márquez-Jurado, S.; Díaz-Colunga, J.; Das Neves, R.P.; Martinez-Lorente, A.; Almazán, F.; Guantes, R.; Iborra, F.J., 2018. Nature Communications. 1. 9. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85041107950&partnerID=MN8TOARS . 10.1038/s41467-017-02787-4 . Nature Communications

Validating the RedMIT/GFP-LC3 Mouse Model by Studying Mitophagy in Autosomal Dominant Optic Atrophy Due to the OPA1Q285STOP Mutation

Neves, Ricardo, 2018. Frontiers in Cell and Developmental Biology. 2018. http://dx.doi.org/10.3389/fcell.2018.00103 . 10.3389/fcell.2018.00103 . Frontiers in Cell and Developmental Biology

Atomistic-Level Investigation of a LL37-Conjugated Gold Nanoparticle By Well-Tempered Metadynamics

André F. Ferreira; Michela Comune; Akhilesh Rai; Lino Ferreira; Pedro N. Simões, 2018. The Journal of Physical Chemistry B. 2018. https://doi.org/10.1021/acs.jpcb.8b05717 . 10.1021/acs.jpcb.8b05717 . The Journal of Physical Chemistry B

Osmotic modulation of chromatin impacts on efficiency and kinetics of cell fate modulation

Neves, Ricardo, 2018. Scientific Reports. 2018. http://dx.doi.org/10.1038/s41598-018-25517-2 . 10.1038/s41598-018-25517-2 . Scientific Reports

STROKE34 Study Protocol: A Randomized Controlled Phase IIa Trial of Intra-Arterial CD34+ Cells in Acute Ischemic Stroke

Ferreira, Lino, 2018. Frontiers in Neurology. 2018. http://dx.doi.org/10.3389/fneur.2018.00302 . 10.3389/fneur.2018.00302 . Frontiers in Neurology

MicroRNA-124-loaded nanoparticles increase survival and neuronal differentiation of neural stem cells in vitro but do not contribute to stroke outcome in vivo

Ferreira, Lino, 2018. PLOS ONE. 2018. http://dx.doi.org/10.1371/journal.pone.0193609 . 10.1371/journal.pone.0193609 . PLOS ONE

Cooperative Transcription Factor Induction Mediates Hemogenic Reprogramming

Ferreira, Lino, 2018. Cell Reports. 2018. http://dx.doi.org/10.1016/j.celrep.2018.11.032 . 10.1016/j.celrep.2018.11.032 . Cell Reports

Osmotic modulation of chromatin impacts on efficiency and kinetics of cell fate modulation

Ferreira, Lino, 2018. Scientific Reports. 2018. http://dx.doi.org/10.1038/s41598-018-25517-2 . 10.1038/s41598-018-25517-2 . Scientific Reports

Endothelial progenitor cells enhance blood-brain barrier permeability in subacute stroke.

Sargento-Freitas J; Aday S; Nunes C; Cordeiro M; Gouveia A; Silva F; Machado C; et al, 2018. Neurology. 2018. http://europepmc.org/abstract/med/29237797 . 10.1212/wnl.0000000000004801 . Neurology

Endothelial Progenitor Cells influence acute and subacute stroke hemodynamics

Ferreira, Lino, 2018. Journal of the Neurological Sciences. 2018. http://dx.doi.org/10.1016/j.jns.2017.12.028 . 10.1016/j.jns.2017.12.028 . Journal of the Neurological Sciences

Stem cells as vehicles and targets of nanoparticles.

Pinho S; Macedo MH; Rebelo C; Sarmento B; Ferreira L, 2018. Drug discovery today. 2018. http://europepmc.org/abstract/med/29337203 . 10.1016/j.drudis.2018.01.030 . Drug discovery today

Substrate Topography Modulates Cell Aging on a Progeria Cell Model

Patricia R. Pitrez; Luís Estronca; Helena Vazão; Anne-Laure Egesipe; Amélie Le Corf; Claire Navarro; Nicolas Lévy; et al, 2018. ACS Biomaterials Science & Engineering. 2018. https://doi.org/10.1021/acsbiomaterials.8b00224 . 10.1021/acsbiomaterials.8b00224 . ACS Biomaterials Science & Engineering

Light-triggerable formulations for the intracellular controlled release of biomolecules.

Lino MM; Ferreira L, 2018. Drug discovery today. 2018. http://europepmc.org/abstract/med/29326080 . 10.1016/j.drudis.2018.01.019 . Drug discovery today

Nanoparticles Conjugated with Photocleavable Linkers for the Intracellular Delivery of Biomolecules

Adrián Jiménez-Balsa; Sandra Pinto; Emanuel Quartin; Miguel M. Lino; Vitor Francisco; Lino Ferreira, 2018. Bioconjugate Chemistry. 2018. https://doi.org/10.1021/acs.bioconjchem.7b00820 . 10.1021/acs.bioconjchem.7b00820 . Bioconjugate Chemistry

Cecropin-Melittin Functionalized Polyurethane Surfaces Prevent Staphylococcus epidermidis Adhesion without Inducing Platelet Adhesion and Activation

Ferreira, Lino, 2018. Advanced Materials Interfaces. 2018. http://dx.doi.org/10.1002/admi.201801390 . 10.1002/admi.201801390 . Advanced Materials Interfaces

Modulation of Angiogenic Activity by Light-Activatable miRNA-Loaded Nanocarriers

Miguel M. Lino; Susana Simões; Andreia Vilaça; Helena Antunes; Alessandra Zonari; Lino Ferreira, 2018. ACS Nano. 2018. https://doi.org/10.1021/acsnano.7b07538 . 10.1021/acsnano.7b07538 . ACS Nano

Findings on the interaction of the antimicrobial peptide cecropin-melittin with a gold surface from molecular dynamics studies

Ferreira, Lino, 2017. European Biophysics Journal. 2017. http://dx.doi.org/10.1007/s00249-016-1160-z . 10.1007/s00249-016-1160-z . European Biophysics Journal

Challenging the great vascular wall: Can we envision a simple yet comprehensive therapy for stroke?

Machado-Pereira M; Santos T; Ferreira L; Bernardino L; Ferreira R, 2017. Journal of tissue engineering and regenerative medicine. 2017. http://europepmc.org/abstract/med/28182332 . 10.1002/term.2427 . Journal of tissue engineering and regenerative medicine

Anti-Inflammatory Strategy for M2 Microglial Polarization Using Retinoic Acid-Loaded Nanoparticles

Ferreira, Lino, 2017. Mediators of Inflammation. 2017. http://dx.doi.org/10.1155/2017/6742427 . 10.1155/2017/6742427 . Mediators of Inflammation

Restoring heart function and electrical integrity: closing the circuit.

Monteiro LM; Vasques-Nóvoa F; Ferreira L; Pinto-do-Ó P; Nascimento DS, 2017. NPJ Regenerative medicine. 2017. http://europepmc.org/abstract/med/29302345 . 10.1038/s41536-017-0015-2 . NPJ Regenerative medicine

Flexible nanofilms coated with aligned piezoelectric microfibers preserve the contractility of cardiomyocytes

Gouveia, P.J.; Rosa, S.; Ricotti, L.; Abecasis, B.; Almeida, H.V.; Monteiro, L.; Nunes, J.; et al, 2017. Biomaterials. 213 - 228. 139. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85020728965&partnerID=MN8TOARS . 10.1016/j.biomaterials.2017.05.048 . Biomaterials

Biomechanical Strain Exacerbates Inflammation on a Progeria-on-a-Chip Model.

Ribas J; Zhang YS; Pitrez PR; Leijten J; Miscuglio M; Rouwkema J; Dokmeci MR; et al, 2017. Small (Weinheim an der Bergstrasse, Germany). 2017. http://europepmc.org/abstract/med/28211642 . 10.1002/smll.201603737 . Small (Weinheim an der Bergstrasse, Germany)

Prolonged intracellular accumulation of light-inducible nanoparticles in leukemia cells allows their remote activation

Boto, C.; Quartin, E.; Cai, Y.; Martín-Lorenzo, A.; Cenador, M.B.G.; Pinto, S.; Gupta, R.; et al, 2017. Nature Communications. 8. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85026559803&partnerID=MN8TOARS . 10.1038/ncomms15204 . Nature Communications

Erratum: Restoring heart function and electrical integrity: Closing the circuit.

Monteiro LM; Vasques-Nóvoa F; Ferreira L; Pinto-do-Ó P; Nascimento DS, 2017. NPJ Regenerative medicine. 2017. http://europepmc.org/abstract/med/29303158 . 10.1038/s41536-017-0020-5 . NPJ Regenerative medicine

Intracellular delivery of more than one protein with spatio-temporal control

Miguel M. Lino; Susana Simões; Sónia Pinho; Lino Ferreira; Lino MM; Simões S; Pinho S; Ferreira L, 2017. Nanoscale. 18668 - 18680. 47. 9. 2017. https://doi.org/10.1039/C7NR02414B . 10.1039/C7NR02414B . Nanoscale

Synthetic microparticles conjugated with VEGF165 improve the survival of endothelial progenitor cells via microRNA-17 inhibition.

Aday S; Zoldan J; Besnier M; Carreto L; Saif J; Fernandes R; Santos T; et al, 2017. Nature communications. 2017. http://europepmc.org/abstract/med/28963481 . 10.1038/s41467-017-00746-7 . Nature communications

Flexible nanofilms coated with aligned piezoelectric microfibers preserve the contractility of cardiomyocytes.

Gouveia PJ; Rosa S; Ricotti L; Abecasis B; Almeida HV; Monteiro L; Nunes J; et al, 2017. Biomaterials. 2017. http://europepmc.org/abstract/med/28622605 . 10.1016/j.biomaterials.2017.05.048 . Biomaterials

Prolonged intracellular accumulation of light-inducible nanoparticles in leukemia cells allows their remote activation

Boto, Carlos; Quartin, Emanuel; Cai, Yijun; Martín-Lorenzo, Alberto; Cenador, María Begoña García; Pinto, Sandra; Gupta, Rajeev; et al, 2017. Nature Communications. 1. 8. 2017. http://dx.doi.org/10.1038/ncomms15204 . 10.1038/ncomms15204 . Nature Communications

Blue light potentiates neurogenesis induced by retinoic acid-loaded responsive nanoparticles.

Santos T; Ferreira R; Quartin E; Boto C; Saraiva C; Bragança J; Peça J; et al, 2017. Acta biomaterialia. 2017. http://europepmc.org/abstract/med/28673742 . 10.1016/j.actbio.2017.06.044 . Acta biomaterialia

Antimicrobial peptide-gold nanoscale therapeutic formulation with high skin regenerative potential.

Comune M; Rai A; Chereddy KK; Pinto S; Aday S; Ferreira AF; Zonari A; et al, 2017. Journal of controlled release : official journal of the Controlled Release Society. 2017. http://europepmc.org/abstract/med/28694030 . 10.1016/j.jconrel.2017.07.007 . Journal of controlled release : official journal of the Controlled Release Society

Exosomes secreted by cardiomyocytes subjected to ischaemia promote cardiac angiogenesis.

Ribeiro-Rodrigues TM; Laundos TL; Pereira-Carvalho R; Batista-Almeida D; Pereira R; Coelho-Santos V; Silva AP; et al, 2017. Cardiovascular research. 2017. http://europepmc.org/abstract/med/28859292 . 10.1093/cvr/cvx118 . Cardiovascular research

High-throughput identification of small molecules that affect human embryonic vascular development.

Vazão H; Rosa S; Barata T; Costa R; Pitrez PR; Honório I; de Vries MR; et al, 2017. Proceedings of the National Academy of Sciences of the United States of America. 2017. http://europepmc.org/abstract/med/28348206 . 10.1073/pnas.1617451114 . Proceedings of the National Academy of Sciences of the United States of America

High-density antimicrobial peptide coating with broad activity and low cytotoxicity against human cells.

Rai A; Pinto S; Evangelista MB; Gil H; Kallip S; Ferreira MG; Ferreira L, 2016. Acta biomaterialia. 2016. http://europepmc.org/abstract/med/26821340 . 10.1016/j.actbio.2016.01.035 . Acta biomaterialia

Nanoparticle-mediated brain drug delivery: Overcoming blood-brain barrier to treat neurodegenerative diseases.

Saraiva C; Praça C; Ferreira R; Santos T; Ferreira L; Bernardino L, 2016. Journal of controlled release : official journal of the Controlled Release Society. 2016. http://europepmc.org/abstract/med/27208862 . 10.1016/j.jconrel.2016.05.044 . Journal of controlled release : official journal of the Controlled Release Society

MicroRNA-124 loaded nanoparticles enhance brain repair in Parkinson's disease.

Saraiva C; Paiva J; Santos T; Ferreira L; Bernardino L, 2016. Journal of controlled release : official journal of the Controlled Release Society. 2016. http://europepmc.org/abstract/med/27269730 . 10.1016/j.jconrel.2016.06.005 . Journal of controlled release : official journal of the Controlled Release Society

Retinoic acid-loaded polymeric nanoparticles enhance vascular regulation of neural stem cell survival and differentiation after ischaemia.

Ferreira R; Fonseca MC; Santos T; Sargento-Freitas J; Tjeng R; Paiva F; Castelo-Branco M; Ferreira LS; Bernardino L, 2016. Nanoscale. 2016. http://europepmc.org/abstract/med/27025400 . 10.1039/c5nr09077f . Nanoscale

Cardiovascular Organ-on-a-Chip Platforms for Drug Discovery and Development

Ferreira, Lino, 2016. Applied In Vitro Toxicology. 2016. http://dx.doi.org/10.1089/aivt.2016.0002 . 10.1089/aivt.2016.0002 . Applied In Vitro Toxicology

Nanomedicine Approaches to Modulate Neural Stem Cells in Brain Repair.

Santos T; Boto C; Saraiva CM; Bernardino L; Ferreira L, 2016. Trends in biotechnology. 2016. http://europepmc.org/abstract/med/26917252 . 10.1016/j.tibtech.2016.02.003 . Trends in biotechnology

High Antimicrobial Activity and Low Human Cell Cytotoxicity of Core-Shell Magnetic Nanoparticles Functionalized with an Antimicrobial Peptide.

Maleki H; Rai A; Pinto S; Evangelista M; Cardoso RM; Paulo C; Carvalheiro T; et al, 2016. ACS applied materials & interfaces. 2016. http://europepmc.org/abstract/med/27074633 . 10.1021/acsami.6b03355 . ACS applied materials & interfaces

Drug screening on Hutchinson Gilford progeria pluripotent stem cells reveals aminopyrimidines as new modulators of farnesylation.

Blondel S; Egesipe AL; Picardi P; Jaskowiak AL; Notarnicola M; Ragot J; Tournois J; et al, 2016. Cell death & disease. 2016. http://europepmc.org/abstract/med/26890144 . 10.1038/cddis.2015.374 . Cell death & disease

Traceable microRNA-124 loaded nanoparticles as a new promising therapeutic tool for Parkinson's disease.

Saraiva C; Ferreira L; Bernardino L, 2016. Neurogenesis (Austin, Tex.). 2016. http://europepmc.org/abstract/med/28405588 . 10.1080/23262133.2016.1256855 . Neurogenesis (Austin, Tex.)

Stem Cell-Based Human Blood-Brain Barrier Models for Drug Discovery and Delivery.

Aday S; Cecchelli R; Hallier-Vanuxeem D; Dehouck MP; Ferreira L, 2016. Trends in biotechnology. 2016. http://europepmc.org/abstract/med/26838094 . 10.1016/j.tibtech.2016.01.001 . Trends in biotechnology

One-step synthesis of high-density peptide-conjugated gold nanoparticles with antimicrobial efficacy in a systemic infection model.

Rai A; Pinto S; Velho TR; Ferreira AF; Moita C; Trivedi U; Evangelista M; et al, 2016. Biomaterials. 2016. http://europepmc.org/abstract/med/26866877 . 10.1016/j.biomaterials.2016.01.051 . Biomaterials

Retinoic acid-loaded polymeric nanoparticles induce neuroprotection in a mouse model for Parkinson's disease.

Esteves M; Cristóvão AC; Saraiva T; Rocha SM; Baltazar G; Ferreira L; Bernardino L, 2015. 2015. http://europepmc.org/abstract/med/25798108 . 10.3389/fnagi.2015.00020 .

Development of a SMCs model from HGPS-iPS and proofs of principle.

Ferreira L, 2015. Orphanet journal of rare diseases. 2015. http://europepmc.org/abstract/PMC/PMC4652490 . 10.1186/1750-1172-10-s2-o3 . Orphanet journal of rare diseases

Global variability in gene expression and alternative splicing is modulated by mitochondrial content

Guantes, R.; Rastrojo, A.; Neves, R.; Lima, A.; Aguado, B.; Iborra, F.J., 2015. Genome Research. 633 - 644. 5. 125. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84929660832&partnerID=MN8TOARS . 10.1101/gr.178426.114 . Genome Research

An overview of new translational, clinical and therapeutic perspectives in laminopathies and other nuclear envelope-related diseases.  Proceedings of the 1st French-Italian meeting on laminopathies & other nuclear envelope-related diseases

Ferreira, Lino, 2015. Orphanet Journal of Rare Diseases . 2015. 10.1186/1750-1172-10-S2-I1 . Orphanet Journal of Rare Diseases

Vascular disease modeling using induced pluripotent stem cells: focus in Hutching-Gilford progeria syndrome.

Pitrez P; Rosa SC; Almeida C; Ferreira L, 2015. 2015. http://europepmc.org/abstract/med/26474704 .

Lysophosphatidic acid enhances survival of human CD34(+) cells in ischemic conditions.

Kostic I; Fidalgo-Carvalho I; Aday S; Vazão H; Carvalheiro T; Grãos M; Duarte A; et al, 2015. Scientific reports. 2015. http://europepmc.org/abstract/med/26553339 . 10.1038/srep16406 . Scientific reports

Boron nitride nanotube-mediated stimulation modulates F/G-actin ratio and mechanical properties of human dermal fibroblasts

Ricotti, L.; Das Neves, R.P.; Ciofani, G.; Canale, C.; Nitti, S.; Mattoli, V.; Mazzolai, B.; Ferreira, L.; Menciassi, A., 2014. Journal of Nanoparticle Research. 2. 16. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84894539117&partnerID=MN8TOARS . 10.1007/s11051-014-2247-z . Journal of Nanoparticle Research

A stable and reproducible human blood-brain barrier model derived from hematopoietic stem cells

Cecchelli, R.; Aday, S.; Sevin, E.; Almeida, C.; Culot, M.; Dehouck, L.; Coisne, C.; et al, 2014. PLoS ONE. 6. 9. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903316132&partnerID=MN8TOARS . 10.1371/journal.pone.0099733 . PLoS ONE

PLGA nanoparticles loaded with host defense peptide LL37 promote wound healing.

Chereddy KK; Her CH; Comune M; Moia C; Lopes A; Porporato PE; Vanacker J; et al, 2014. 2014. http://europepmc.org/abstract/med/25173841 . 10.1016/j.jconrel.2014.08.016 .

Boron nitride nanotube-mediated stimulation modulates F/G-actin ratio and mechanical properties of human dermal fibroblasts

Ricotti, L.; Das Neves, R.P.; Ciofani, G.; Canale, C.; Nitti, S.; Mattoli, V.; Mazzolai, B.; Ferreira, L.; Menciassi, A., 2014. Journal of Nanoparticle Research. 2. 16. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84894539117&partnerID=MN8TOARS . 10.1007/s11051-014-2247-z . Journal of Nanoparticle Research

Interaction of fullerene nanoparticles with biomembranes: From the partition in lipid membranes to effects on mitochondrial bioenergetics

Santos, S.M.; Dinis, A.M.; Peixoto, F.; Ferreira, L.; Jurado, A.S.; Videira, R.A., 2014. Toxicological Sciences. 117 - 129. 1. 138. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84894311599&partnerID=MN8TOARS . 10.1093/toxsci/kft327 . Toxicological Sciences

Combined Surface Micropatterning and Reactive Chemistry Maximizes Tissue Adhesion with Minimal Inflammation

Pereira, M.J.N.; Sundback, C.A.; Lang, N.; Cho, W.K.; Pomerantseva, I.; Ouyang, B.; Tao, S.L.; et al, 2014. Advanced Healthcare Materials. 565 - 571. 4. 3. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84898634094&partnerID=MN8TOARS . 10.1002/adhm.201300264 . Advanced Healthcare Materials

Inflammatory modulation of stem cells by Magnetic Resonance Imaging (MRI)-detectable nanoparticles

Ferreira, Lino, 2014. RSC Adv.. 2014. http://dx.doi.org/10.1039/c4ra04041d . 10.1039/c4ra04041d . RSC Adv.

A blood-resistant surgical glue for minimally invasive repair of vessels and heart defects

Lang, N.; Pereira, M.J.; Lee, Y.; Friehs, I.; Vasilyev, N.V.; Feins, E.N.; Ablasser, K.; et al, 2014. Science Translational Medicine. 218. 6. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84892553926&partnerID=MN8TOARS . 10.1126/scitranslmed.3006557 . Science Translational Medicine

Efficient pro-survival/angiogenic miRNA delivery by an MRI-detectable nanomaterial

Gomes, R.S.M.; Neves, R.P.D.; Cochlin, L.; Lima, A.; Carvalho, R.; Korpisalo, P.; Dragneva, G.; et al, 2013. ACS Nano. 3362 - 3372. 4. 7. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876588539&partnerID=MN8TOARS . 10.1021/nn400171w . ACS Nano

Efficient pro-survival/angiogenic miRNA delivery by an MRI-detectable nanomaterial

Gomes, R.S.M.; Neves, R.P.D.; Cochlin, L.; Lima, A.; Carvalho, R.; Korpisalo, P.; Dragneva, G.; et al, 2013. ACS Nano. 3362 - 3372. 4. 7. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876588539&partnerID=MN8TOARS . 10.1021/nn400171w . ACS Nano

Differential internalization of amphotericin B - Conjugated nanoparticles in human cells and the expression of heat shock protein 70

Paulo, C.S.O.; Lino, M.M.; Matos, A.A.; Ferreira, L.S., 2013. Biomaterials. 5281 - 5293. 21. 34. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84877046831&partnerID=MN8TOARS . 10.1016/j.biomaterials.2013.03.048 . Biomaterials

Antifungal activity of dental resins containing amphotericin B-conjugated nanoparticles

Lino, M.M.; Paulo, C.S.O.; Vale, A.C.; Vaz, M.F.; Ferreira, L.S., 2013. Dental Materials. 10. 29. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884143064&partnerID=MN8TOARS . 10.1016/j.dental.2013.07.023 . Dental Materials

A highly tunable biocompatible and multifunctional biodegradable elastomer

Pereira, M.J.N.; Ouyang, B.; Sundback, C.A.; Lang, N.; Friehs, I.; Mureli, S.; Pomerantseva, I.; et al, 2013. Advanced Materials. 1209 - 1215. 8. 25. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874103151&partnerID=MN8TOARS . 10.1002/adma.201203824 . Advanced Materials

Boron Nitride Nanotube-Mediated Stimulation of Cell Co-Culture on Micro-Engineered Hydrogels

Ricotti, L.; Fujie, T.; Vazão, H.; Ciofani, G.; Marotta, R.; Brescia, R.; Filippeschi, C.; et al, 2013. PLoS ONE. 8. 8. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84881503335&partnerID=MN8TOARS . 10.1371/journal.pone.0071707 . PLoS ONE

Nanomedicine boosts neurogenesis: New strategies for brain repair

Santos, T.; Maia, J.; Agasse, F.; Xapelli, S.; Ferreira, L.; Bernardino, L., 2012. Integrative Biology (United Kingdom). 973 - 981. 9. 4. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870939373&partnerID=MN8TOARS . 10.1039/c2ib20129a . Integrative Biology (United Kingdom)

Mitochondrial variability as a source of extrinsic cellular noise

Johnston, I.G.; Gaal, B.; das Neves, R.P.; Enver, T.; Iborra, F.J.; Jones, N.S., 2012. PLoS Computational Biology. 3. 8. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861161954&partnerID=MN8TOARS . 10.1371/journal.pcbi.1002416 . PLoS Computational Biology

VEGF-functionalized dextran has longer intracellular bioactivity than VEGF in endothelial cells

Maia, J.; Vazão, H.; Pedroso, D.C.S.; Jesus, C.S.H.; Brito, R.M.M.; Grãos, M.; Gil, M.H.; Ferreira, L., 2012. Biomacromolecules. 2906 - 2916. 9. 13. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866111153&partnerID=MN8TOARS . 10.1021/bm3009268 . Biomacromolecules

Nanoparticles and surfaces presenting antifungal, antibacterial and antiviral properties

Botequim, D.; Maia, J.; Lino, M.M.F.; Lopes, L.M.F.; Simões, P.N.; Ilharco, L.M.; Ferreira, L., 2012. Langmuir. 7646 - 7656. 20. 28. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861396966&partnerID=MN8TOARS . 10.1021/la300948n . Langmuir

Proliferation and skeletal myotube formation capability of C2C12 and H9c2 cells on isotropic and anisotropic electrospun nanofibrous PHB scaffolds

Ricotti, L.; Polini, A.; Genchi, G.G.; Ciofani, G.; Iandolo, D.; Vazão, H.; Mattoli, V.; et al, 2012. Biomedical Materials. 3. 7. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860717976&partnerID=MN8TOARS . 10.1088/1748-6041/7/3/035010 . Biomedical Materials

Polymeric nanoparticles to control the differentiation of neural stem cells in the subventricular zone of the brain

Santos, T.; Ferreira, R.; Maia, J.; Agasse, F.; Xapelli, S.; Cortes, L.; Bragancia, J.; et al, 2012. ACS Nano. 10463 - 10474. 12. 6. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84871596644&partnerID=MN8TOARS . 10.1021/nn304541h . ACS Nano

Epigenetic engineering to reverse the Parkinson's expression state

Valente, A.X.C.N.; das Neves, R.P.; Oliveira, P.J., 2012. Parkinsonism and Related Disorders. 717 - 721. 6. 18. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862191970&partnerID=MN8TOARS . 10.1016/j.parkreldis.2012.04.018 . Parkinsonism and Related Disorders

Histamine modulates microglia function.

Ferreira R; Santos T; Gonçalves J; Baltazar G; Ferreira L; Agasse F; Bernardino L, 2012. 2012. http://europepmc.org/abstract/med/22569158 . 10.1186/1742-2094-9-90 .

Histamine stimulates neurogenesis in the rodent subventricular zone

Bernardino, L.; Eiriz, M.F.; Santos, T.; Xapelli, S.; Grade, S.; Rosa, A.I.; Cortes, L.; et al, 2012. Stem Cells. 773 - 784. 4. 30. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859512101&partnerID=MN8TOARS . 10.1002/stem.1042 . Stem Cells

Nanoparticles for intracellular-targeted drug delivery

Paulo, C.S.O.; Pires Das Neves, R.; Ferreira, L.S., 2011. Nanotechnology. 49. 22. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-81855212480&partnerID=MN8TOARS . 10.1088/0957-4484/22/49/494002 . Nanotechnology

Three-dimensional biomaterials for the study of human pluripotent stem cells

Kraehenbuehl, T.P.; Langer, R.; Ferreira, L.S., 2011. Nature Methods. 731 - 736. 9. 8. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80052294065&partnerID=MN8TOARS . 10.1038/nmeth.1671 . Nature Methods

Human embryonic stem cell-derived microvascular grafts for cardiac tissue preservation after myocardial infarction

Kraehenbuehl, T.P.; Ferreira, L.S.; Hayward, A.M.; Nahrendorf, M.; van der Vlies, A.J.; Vasile, E.; Weissleder, R.; Langer, R.; Hubbell, J.A., 2011. Biomaterials. 1102 - 1109. 4. 32. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-78649446021&partnerID=MN8TOARS . 10.1016/j.biomaterials.2010.10.005 . Biomaterials

Controlling the neuronal differentiation of stem cells by the intracellular delivery of retinoic acid-loaded nanoparticles

Maia, J.; Santos, T.; Aday, S.; Agasse, F.; Cortes, L.; Malva, J.O.; Bernardino, L.; Ferreira, L., 2011. ACS Nano. 97 - 106. 1. 5. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955113748&partnerID=MN8TOARS . 10.1021/nn101724r . ACS Nano

Sensing the cardiac environment: Exploiting cues for regeneration

Pereira, M.J.N.; Carvalho, I.F.; Karp, J.M.; Ferreira, L.S., 2011. Journal of Cardiovascular Translational Research. 616 - 630. 5. 4. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-81855221996&partnerID=MN8TOARS . 10.1007/s12265-011-9299-6 . Journal of Cardiovascular Translational Research

Towards the maturation and characterization of smooth muscle cells derived from human embryonic stem cells

Vazão, H.; das Neves, R.P.; Grãos, M.; Ferreira, L., 2011. PLoS ONE. 3. 6. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952523704&partnerID=MN8TOARS . 10.1371/journal.pone.0017771 . PLoS ONE

a-MSH regulates intergenic splicing of MC1R and TUBB3 in human melanocytes

Dalziel, M.; Kolesnichenko, M.; Das Neves, R.P.; Iborra, F.; Goding, C.; Furger, A., 2011. Nucleic Acids Research. 2378 - 2392. 6. 39. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953710861&partnerID=MN8TOARS . 10.1093/nar/gkq1125 . Nucleic Acids Research

Towards the maturation and characterization of smooth muscle cells derived from human embryonic stem cells

Vazão, H.; das Neves, R.P.; Grãos, M.; Ferreira, L., 2011. PLoS ONE. 3. 6. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952523704&partnerID=MN8TOARS . 10.1371/journal.pone.0017771 . PLoS ONE

Nanoparticles for intracellular-targeted drug delivery

Paulo, C.S.O.; Pires Das Neves, R.; Ferreira, L.S., 2011. Nanotechnology. 49. 22. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-81855212480&partnerID=MN8TOARS . 10.1088/0957-4484/22/49/494002 . Nanotechnology

Improved survival, vascular differentiation and wound healing potential of stem cells co-cultured with endothelial cells

Pedroso, D.C.S.; Tellechea, A.; Moura, L.; Fidalgo-Carvalho, I.; Duarte, J.; Carvalho, E.; Ferreira, L., 2011. PLoS ONE. 1. 6. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79551528768&partnerID=MN8TOARS . 10.1371/journal.pone.0016114 . PLoS ONE

Antifungal nanoparticles and surfaces

Paulo, C.S.O.; Vidal, M.; Ferreira, L.S., 2010. Biomacromolecules. 2810 - 2817. 10. 11. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957868674&partnerID=MN8TOARS . 10.1021/bm100893r . Biomacromolecules

Stem cell-based therapies for heart regeneration: What did the bench teach us?

Ferreira, L.; Pedroso, D.C.S.; Vazão, H.; Gomes, R.S.M., 2010. Cardiovascular and Hematological Disorders - Drug Targets. 173 - 185. 3. 10. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-78549255903&partnerID=MN8TOARS . Cardiovascular and Hematological Disorders - Drug Targets

MicroRNA-210 regulates mitochondrial free radical response to hypoxia and krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU

Favaro, E.; Ramachandran, A.; McCormick, R.; Gee, H.; Blancher, C.; Crosby, M.; Devlin, C.; et al, 2010. PLoS ONE. 4. 5. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956402239&partnerID=MN8TOARS . 10.1371/journal.pone.0010345 . PLoS ONE

Connecting variability in global transcription rate to mitochondrial variability

das Neves, R.P.; Jones, N.S.; Andreu, L.; Gupta, R.; Enver, T.; Iborra, F.J., 2010. PLoS Biology. 12. 8. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650442826&partnerID=MN8TOARS . 10.1371/journal.pbio.1000560 . PLoS Biology

Vascular differentiation of human embryonic stem cells in bioactive hydrogel-based scaffolds.

Gerecht, S.; Ferreira, L.S.; Langer, R.; Gerecht S; Ferreira LS; Langer R, 2010. Methods in molecular biology (Clifton, N.J.). 333 - 354. 584. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-75649126900&partnerID=MN8TOARS . 10.1007/978-1-60761-369-5_18 . Methods in molecular biology (Clifton, N.J.)

Isolation, differentiation and characterization of vascular cells derived from human embryonic stem cells.

Levenberg, S.; Ferreira, L.S.; Chen-Konak, L.; Kraehenbuehl, T.P.; Langer, R., 2010. Nature protocols. 1115 - 1126. 6. 5. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956696064&partnerID=MN8TOARS . 10.1038/nprot.2010.31 . Nature protocols

Nanoparticles as tools to study and control stem cells

Ferreira, L., 2009. Journal of Cellular Biochemistry. 746 - 752. 4. 108. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-70350435073&partnerID=MN8TOARS . 10.1002/jcb.22303 . Journal of Cellular Biochemistry

Non-leaching surfaces capable of killing microorganisms on contact

Ferreira, L.; Zumbuehl, A., 2009. Journal of Materials Chemistry. 7796 - 7806. 42. 19. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-70350722395&partnerID=MN8TOARS . 10.1039/b905668h . Journal of Materials Chemistry

Cell-responsive hydrogel for encapsulation of vascular cells

Kraehenbuehl, T.P.; Ferreira, L.S.; Zammaretti, P.; Hubbell, J.A.; Langer, R., 2009. Biomaterials. 4318 - 4324. 26. 30. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-67650596617&partnerID=MN8TOARS . 10.1016/j.biomaterials.2009.04.057 . Biomaterials

A biodegradable and biocompatible gecko-inspired tissue adhesive

Mahdavi, A.; Ferreira, L.; Sundback, C.; Nichol, J.W.; Chan, E.P.; Carter, D.J.D.; Bettinger, C.J.; et al, 2008. Proceedings of the National Academy of Sciences of the United States of America. 2307 - 2312. 7. 105. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-40649128784&partnerID=MN8TOARS . 10.1073/pnas.0712117105 . Proceedings of the National Academy of Sciences of the United States of America

Intracellular delivery of core-shell fluorescent silica nanoparticles

Fuller, J.E.; Zugates, G.T.; Ferreira, L.S.; Ow, H.S.; Nguyen, N.N.; Wiesner, U.B.; Langer, R.S., 2008. Biomaterials. 1526 - 1532. 10. 29. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-38549088954&partnerID=MN8TOARS . 10.1016/j.biomaterials.2007.11.025 . Biomaterials

Association between active genes occurs at nuclear speckles and is modulated by chromatin environment

Brown, J.M.; Green, J.; Das Neves, R.P.; Neves, R.P.D.; Wallace, H.A.C.; Smith, A.J.H.; Hughes, J.; et al, 2008. Chemtracts. 411 - 413. 10. 21. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-66849113444&partnerID=MN8TOARS . 10.1083/jcb.200803174 . Chemtracts

Human embryoid bodies containing nano- And microparticulate delivery vehicles

Ferreira, L.; Squier, T.; Park, H.; Choe, H.; Kohane, D.S.; Langer, R., 2008. Advanced Materials. 2285 - 2291. 12. 20. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-48349136691&partnerID=MN8TOARS . 10.1002/adma.200702404 . Advanced Materials

New Opportunities: The Use of Nanotechnologies to Manipulate and Track Stem Cells

Ferreira, L.; Karp, J.M.; Nobre, L.; Langer, R., 2008. Cell Stem Cell. 136 - 146. 2. 3. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-48349135069&partnerID=MN8TOARS . 10.1016/j.stem.2008.07.020 . Cell Stem Cell

Repeated administration of d-amphetamine results in a time-dependent and dose-independent sustained increase in urinary excretion of p-hydroxyamphetamine in mice

Carvalho, F.; Soares, M.E.; Fernandes, E.; Remião, F.; Carvalho, M.; Duarte, J.A.; Pires-das-Neves, R.; Pereira, M.D.L.; Bastos, M.D.L., 2007. Journal of Health Science. 371 - 377. 4. 53. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34547566233&partnerID=MN8TOARS . 10.1248/jhs.53.371 . Journal of Health Science

Antifungal hydrogels

Zumbuehl, A.; Ferreira, L.; Kuhn, D.; Astashkina, A.; Long, L.; Yeo, Y.; Iaconis, T.; et al, 2007. Proceedings of the National Academy of Sciences of the United States of America. 12994 - 12998. 32. 104. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548767010&partnerID=MN8TOARS . 10.1073/pnas.0705250104 . Proceedings of the National Academy of Sciences of the United States of America

Synthesis and characterization of photocurable elastomers from poly(glycerol-co-sebacate)

Nijst, C.L.E.; Bruggeman, J.P.; Karp, J.M.; Ferreira, L.; Zumbuehl, A.; Bettinger, C.J.; Langer, R., 2007. Biomacromolecules. 3067 - 3073. 10. 8. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-35548988907&partnerID=MN8TOARS . 10.1021/bm070423u . Biomacromolecules

Vascular progenitor cells isolated from human embryonic stem cells give rise to endothelial and smooth muscle-like cells and form vascular networks in vivo

Ferreira, L.S.; Gerecht, S.; Shieh, H.F.; Watson, N.; Rupnick, M.A.; Dallabrida, S.M.; Vunjak-Novakovic, G.; Langer, R., 2007. Circulation Research. 286 - 294. 3. 101. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548335261&partnerID=MN8TOARS . 10.1161/CIRCRESAHA.107.150201 . Circulation Research

Bioactive hydrogel scaffolds for controllable vascular differentiation of human embryonic stem cells

Ferreira, L.S.; Gerecht, S.; Fuller, J.; Shieh, H.F.; Vunjak-Novakovic, G.; Langer, R., 2007. Biomaterials. 2706 - 2717. 17. 28. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947253443&partnerID=MN8TOARS . 10.1016/j.biomaterials.2007.01.021 . Biomaterials

Hyaluronic acid hydrogel for controlled self-renewal and differentiation of human embryonic stem cells

Gerecht, S.; Burdick, J.A.; Ferreira, L.S.; Townsend, S.A.; Langer, R.; Vunjak-Novakovic, G., 2007. Proceedings of the National Academy of Sciences of the United States of America. 11298 - 11303. 27. 104. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34547479732&partnerID=MN8TOARS . 10.1073/pnas.0703723104 . Proceedings of the National Academy of Sciences of the United States of America

Structural analysis of dextran-based hydrogels obtained chemoenzymatically

Ferreira, L.; Figueirecio, M.M.; Gil, M.H.; Ramos, M.A., 2006. Journal of Biomedical Materials Research - Part B Applied Biomaterials. 55 - 64. 1. 77. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33645418697&partnerID=MN8TOARS . 10.1002/jbm.b.30394 . Journal of Biomedical Materials Research - Part B Applied Biomaterials

Co-culture of human embryonic stem cells with murine embryonic fibroblasts on microwell-patterned substrates

Khademhosseini, A.; Ferreira, L.; Blumling III, J.; Yeh, J.; Karp, J.M.; Fukuda, J.; Langer, R., 2006. Biomaterials. 5968 - 5977. 36. 27. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748769776&partnerID=MN8TOARS . 10.1016/j.biomaterials.2006.06.035 . Biomaterials

Cultivation of human embryonic stem cells without the embryoid body step enhances osteogenesis in vitro

Karp, J.M.; Ferreira, L.S.; Khademhosseini, A.; Kwon, A.H.; Yeh, J.; Langer, R.S., 2006. Stem Cells. 835 - 843. 4. 24. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745504422&partnerID=MN8TOARS . 10.1634/stemcells.2005-0383 . Stem Cells

Synthesis and characterization of new injectable and degradable dextran-based hydrogels

Maia, J.; Ferreira, L.; Carvalho, R.; Ramos, M.A.; Gil, M.H., 2005. Polymer. 9604 - 9614. 23. 46. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-26844528911&partnerID=MN8TOARS . 10.1016/j.polymer.2005.07.089 . Polymer

Improving the adhesion of poly(ethylene terephthalate) fibers to poly(hydroxyethyl methacrylate) hydrogels by ozone treatment: Surface characterization and pull-out tests

Ferreira, L.; Evangelista, M.B.; Martins, M.C.L.; Granja, P.L.; Esteves, J.L.; Barbosa, M.A., 2005. Polymer. 9840 - 9850. 23. 46. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-26844540116&partnerID=MN8TOARS . 10.1016/j.polymer.2005.08.033 . Polymer

Biocatalytic synthesis of highly ordered degradable dextran-based hydrogels

Ferreira, L.; Gil, M.H.; Cabrita, A.M.S.; Dordick, J.S., 2005. Biomaterials. 4707 - 4716. 23. 26. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-14844303889&partnerID=MN8TOARS . 10.1016/j.biomaterials.2004.11.051 . Biomaterials

Effect of Cr(V) on reproductive organ morphology and sperm parameters: An experimental study in mice

Pereira, M.D.L.; Das Neves, R.P.; Oliveira, H.; Santos, T.M.; De Jesus, J.P., 2005. Environmental Health: A Global Access Science Source. 4. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-23944463762&partnerID=MN8TOARS . 10.1186/1476-069X-4-9 . Environmental Health: A Global Access Science Source

Protective activity of hesperidin and lipoic acid against sodium arsenite acute toxicity in mice

Pires Das Neves, R.N.; Carvalho, F.; Carvalho, M.; Fernandes, E.; Soares, E.; Bastos, M.D.L.; Pereira, M.D.L., 2004. Toxicologic Pathology. 527 - 535. 5. 32. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-4544289287&partnerID=MN8TOARS . 10.1080/01926230490502566 . Toxicologic Pathology

Hypericum androsaemum infusion increases tert-butyl hydroperoxide-induced mice hepatotoxicity in vivo

Valentão, P.; Carvalho, M.; Carvalho, F.; Fernandes, E.; Neves, R.P.D.; Pereira, M.L.; Andrade, P.B.; Seabra, R.M.; Bastos, M.L., 2004. Journal of Ethnopharmacology. 345 - 351. 2-3. 94. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-4344716319&partnerID=MN8TOARS . 10.1016/j.jep.2004.06.012 . Journal of Ethnopharmacology

Biocompatibility of chemoenzymatically derived dextran-acrylate hydrogels

Ferreira, L.; Rafael, A.; Lamghari, M.; Barbosa, M.A.; Gil, M.H.; Cabrita, A.M.S.; Dordick, J.S., 2004. Journal of Biomedical Materials Research - Part A. 584 - 596. 3. 68. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-1342280525&partnerID=MN8TOARS . Journal of Biomedical Materials Research - Part A

Influence of different silica derivatives in the immobilization and stabilization of a Bacillus licheniformis protease (Subtilisin Carlsberg)

Ferreira, L.; Ramos, M.A.; Dordick, J.S.; Gil, M.H., 2003. Journal of Molecular Catalysis B: Enzymatic. 189 - 199. 4-6. 21. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0347297355&partnerID=MN8TOARS . 10.1016/S1381-1177(02)00223-0 . Journal of Molecular Catalysis B: Enzymatic

Effect of 3,4-methylenedioxymethamphetamine ("ecstasy") on body temperature and liver antioxidant status in mice: Influence of ambient temperature

Carvalho, M.; Carvalho, F.; Remião, F.; De Lourdes Pereira, M.; Pires-Das-Neves, R.; De Lourdes Bastos, M., 2002. Archives of Toxicology. 166 - 172. 3. 76. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036214775&partnerID=MN8TOARS . 10.1007/s00204-002-0324-z . Archives of Toxicology

Comparative histological studies on liver of mice exposed to Cr(VI) and Cr(V) compounds

Pires Das Neves, R.; Santos, T.M.; De Lourdes Pereira, M.; Pedrosa De Jesus, J., 2002. Human and Experimental Toxicology. 365 - 369. 7. 21. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036656032&partnerID=MN8TOARS . 10.1191/0960327102ht243oa . Human and Experimental Toxicology

Cr(V) involvement in the toxicity pathway of testicular damage

Pereira, M.L.; Santos, T.M.; Pires das Neves, R.; Costa, F.G.; Pedrosa de Jesus, J., 2002. Asian Journal of Andrology. 153 - 155. 2. 4. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035987253&partnerID=MN8TOARS . Asian Journal of Andrology

Enzymatic synthesis of dextran-containing hydrogels

Ferreira, L.; Gil, M.H.; Dordick, J.S.; Carvalho, R., 2002. Biomaterials. 3957 - 3967. 19. 23. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036020043&partnerID=MN8TOARS . 10.1016/S0142-9612(02)00132-1 . Biomaterials

Biocatalytic polytransesterification of inulin with divinyladipate

Ferreira, L.; Gil, M.H.; Carvalho, R.; Geraldes, C.F.G.C.; Kim, D.-Y.; Dordick, J.S., 2002. Chemistry of Materials. 4009 - 4011. 10. 14. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036799646&partnerID=MN8TOARS . 10.1021/cm020393w . Chemistry of Materials

Exquisite regioselectivity and increased transesterification activity of an immobilized Bacillus subtilis protease

Ferreira, L.; Ramos, M.A.; Gil, M.H.; Dordick, J.S., 2002. Biotechnology Progress. 986 - 993. 5. 18. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036753108&partnerID=MN8TOARS . 10.1021/bp0255457 . Biotechnology Progress

Design of a drug-delivery system based on polyacrylamide hydrogels. Evaluation of structural properties

Ferreira, Lino, 2001. Chemical educator. 2001. http://link.springer.com/article/10.1007%2Fs00897010461a . 10.1007/s00897010461a . Chemical educator

Chromium(VI) induced alterations in mouse spleen cells: A short-term assay

Das Neves, R.P.; Santos, T.M.; Pereira, M.D.L.; De Jesus, J.P., 2001. Cytobios. 27 - 34. 1 SUPPL.. 413. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0348238820&partnerID=MN8TOARS . Cytobios

Evaluation of poly(2-hydroxyethyl methacrylate) gels as drug delivery systems at different pH values

Ferreira, L.; Vidal, M.M.; Gil, M.H., 2000. International Journal of Pharmaceutics. 169 - 180. 2. 194. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033968976&partnerID=MN8TOARS . 10.1016/S0378-5173(99)00375-0 . International Journal of Pharmaceutics

Preparation and characterization of gels based on sucrose modified with glycidyl methacrylate

Ferreira, L.; Vidal, M.M.; Geraldes, C.F.G.C.; Gil, M.H., 2000. Carbohydrate Polymers. 15 - 24. 1. 41. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033908440&partnerID=MN8TOARS . 10.1016/S0144-8617(99)00064-8 . Carbohydrate Polymers

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