The research group was created in January 2008 at the University of Coimbra. The research group aims at generating knowledge to better understand and treat age-related diseases, namely cardiovascular diseases.
The research group has two main avenues of research:
Aging and disease modeling, and drug screening programs: to identify new therapeutic targets. A particular interest of the group is to study age-related diseases, particularly the ones related with the cardiovascular system, using in vitro human tissues created by induced pluripotent stem cells (iPSCs). The tissues can also be used for drug screening programs to identify new therapeutic targets.
Nanomedicine research program: to deliver more efficiently pharmacological interventions in living systems. Another interest of the group is in the development of advanced formulations for the controlled delivery of drugs to enhance tissue/organ regeneration and control aging processes.
In the coming years, the group will contribute to several fronts including: (i) the investigation of cardiac ageing; (ii) to develop new strategies to deliver efficiently anti-aging drugs to the heart; (iii) to develop new interventions to prevent or slow down vascular ageing; (iv) to develop new therapeutic formulations to reprogram aged cells into functional cells. The group will contribute for curricular units of the PhD in Experimental Biology and Biomedicine (BEB) and PhD in Health Sciences, both at the University of Coimbra. In addition, the group will coordinate a curricular unit named as “Regenerative Medicine” at the Integrated Master of Biomedical Engineering and in the Master of Cell and Molecular Biology.
More about the group here.
Information about journal articles, updated at 03-11-2024, from platform CIÊNCIAVITAE.
Remodeling of the Cardiac Extracellular Matrix Proteome During Chronological and Pathological Aging
Santinha, Deolinda; Vilaça, Andreia; Estronca, Luís; Schüler, Svenja C.; Bartoli, Catherine; De Sandre-Giovannoli, Annachiara; Figueiredo, Arnaldo; et al, 2024. Mol Cell Proteomics. 1. 23. 2024. 10.1016/j.mcpro.2023.100706 . published Mol Cell Proteomics
Nanoparticle-encapsulated retinoic acid for the modulation of bone marrow hematopoietic stem cell niche
Emanuel Quartin; Susana Rosa; Sara Gonzalez-Anton; Laura Mosteo Lopez; Vitor Francisco; Delfim Duarte; Cristina Lo Celso; Ricardo Pires das Neves; Lino Ferreira, 2024. Bioactive Materials. 2024. https://doi.org/10.1016/j.bioactmat.2023.12.017 . 10.1016/j.bioactmat.2023.12.017 . Bioactive Materials
Nanoparticle-encapsulated retinoic acid for the modulation of bone marrow hematopoietic stem cell niche
Emanuel Quartin; Susana Rosa; Sara Gonzalez-Anton; Laura Mosteo Lopez; Vitor Francisco; Delfim Duarte; Cristina Lo Celso; Ricardo Pires das Neves; Lino Ferreira, 2024. Bioactive Materials. 2024. https://doi.org/10.1016/j.bioactmat.2023.12.017 . 10.1016/j.bioactmat.2023.12.017 . Bioactive Materials
Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule
Kelly, George; Kataura, Tetsushi; Panek, Johan; Ma, Gailing; Salmonowicz, Hanna; Davis, Ashley; Kendall, Hannah; et al, 2024. Developmental Cell. 2024. http://dx.doi.org/10.1016/j.devcel.2024.04.020 . 10.1016/j.devcel.2024.04.020 . Developmental Cell
Extracellular vesicle transfer of lncRNA H19 splice variants to cardiac cells
Andreia Vilaça; Carlos Jesus; Miguel Lino; Danika Hayman; Costanza Emanueli; Cesare M. Terracciano; Hugo Fernandes; Leon J. de Windt; Lino Ferreira, 2024. Molecular Therapy - Nucleic Acids. 2024. https://doi.org/10.1016/j.omtn.2024.102233 . 10.1016/j.omtn.2024.102233 . Molecular Therapy - Nucleic Acids
Near-Infrared Light Activated Formulation for the Spatially Controlled Release of CRISPR-Cas9 Ribonucleoprotein for Brain Gene Editing
Simões, Susana; Lino, Miguel; Barrera, Angela; Rebelo, Catarina; Tomatis, Francesca; Vilaça, Andreia; Breunig, Christopher; et al, 2024. Angewandte Chemie International Edition. 2024. http://dx.doi.org/10.1002/anie.202401004 . 10.1002/anie.202401004 . Angewandte Chemie International Edition
Cellular reprogramming as a tool to model human aging in a dish
Patricia R. Pitrez; Luis M. Monteiro; Oliver Borgogno; Xavier Nissan; Jerome Mertens; Lino Ferreira, 2024. Nature Communications. 2024. https://doi.org/10.1038/s41467-024-46004-5 . 10.1038/s41467-024-46004-5 . Nature Communications
Reconstruction of cell-specific models capturing the influence of metabolism on DNA methylation in cancer
Tânia Barata; Vítor Pereira; Ricardo Pires das Neves; Miguel Rocha, 2024. Computers in Biology and Medicine. 2024. https://doi.org/10.1016/j.compbiomed.2024.108052 . 10.1016/j.compbiomed.2024.108052 . Computers in Biology and Medicine
POSEIDON: Peptidic Objects SEquence-based Interaction with cellular DOmaiNs: a new database and predictor
Preto, António J.; Caniceiro, Ana B.; Duarte, Francisco; Fernandes, Hugo; Ferreira, Lino; Mourão, Joana; Moreira, Irina S., 2024. Journal of Cheminformatics. 1. 16. 2024. http://dx.doi.org/10.1186/s13321-024-00810-7 . 10.1186/s13321-024-00810-7 . Journal of Cheminformatics
Imaging platforms to dissect the in vivo communication, biodistribution and controlled release of extracellular vesicles
Banerjee, Arnab; Lino, Miguel; Jesus, Carlos; Ribeiro, Quélia; Abrunhosa, Antero; Ferreira, Lino, 2023. Journal of Controlled Release. 549 - 563. 360. 2023. http://dx.doi.org/10.1016/j.jconrel.2023.06.039 . 10.1016/j.jconrel.2023.06.039 . Journal of Controlled Release
Small extracellular vesicles administered directly in the brain promote neuroprotection and decreased microglia reactivity in a stroke mouse model
Lino, Miguel M.; Rondão, Tiago; Banerjee, Arnab; Aires, Inês; Rodrigues, Magda; Reis, Tiago; Santinha, António; et al, 2023. Nanoscale. 18212 - 18217. 45. 15. 2023. http://dx.doi.org/10.1039/d3nr03861k . 10.1039/d3nr03861k . Nanoscale
Retinoic Acid-Loaded Nanoparticles Promote Neurovascular Protection in Stroke.
Marta Pereira; Alba Grayston; Miguel García-Gabilondo; Vitor Francisco; Ana Clara Cristovao; João Pedro Marto; Helena L. A. Vieira; et al, 2023. Stroke. 2023. https://doi.org/10.1161/STROKEAHA.122.041839 . 10.1161/strokeaha.122.041839 . Stroke
Reconsidering the role of blood-brain barrier in Alzheimer's disease: From delivery to target.
Sousa JA; Bernardes C; Bernardo-Castro S; Lino M; Albino I; Ferreira L; Brás J; et al, 2023. Frontiers in aging neuroscience. 2023. https://europepmc.org/articles/PMC9978015 . 10.3389/fnagi.2023.1102809 . Frontiers in aging neuroscience
Engineering optical tools for remotely controlled brain stimulation and regeneration
Artur Filipe Rodrigues; Catarina Rebelo; Tiago Reis; Susana Simões; Liliana Bernardino; João Peça; Lino Ferreira, 2023. Biomaterials Science. 2023. https://doi.org/10.1039/D2BM02059A . 10.1039/D2BM02059A . Biomaterials Science
Author Correction: Efficient spatially targeted gene editing using a near-infrared activatable protein-conjugated nanoparticle for brain applications
Catarina Rebelo; Tiago Reis; Joana Guedes; Cláudia Saraiva; Artur Filipe Rodrigues; Susana Simões; Liliana Bernardino; et al, 2023. Nature Communications. 2023. https://doi.org/10.1038/s41467-023-39976-3 . 10.1038/s41467-023-39976-3 . Nature Communications
Acidic sophorolipid and antimicrobial peptide based formulation as antimicrobial and antibiofilm agents.
Seena S; Ferrão R; Pala M; Roelants SLKW; Soetaert W; Stevens CV; Ferreira L; Rai A, 2023. Biomaterials advances. 2023. https://doi.org/10.1016/j.bioadv.2023.213299 . 10.1016/j.bioadv.2023.213299 . Biomaterials advances
Designing Cell Delivery Peptides and SARS-CoV-2-Targeting Small Interfering RNAs: A Comprehensive Bioinformatics Study with Generative Adversarial Network-Based Peptide Design and <i>In Vitro</i> Assays
González, Ricardo D.; Simões, Susana; Ferreira, Lino; Carvalho, Alexandra T. P., 2023. Molecular Pharmaceutics. 6079 - 6089. 12. 20. 2023. http://dx.doi.org/10.1021/acs.molpharmaceut.3c00444 . 10.1021/acs.molpharmaceut.3c00444 . Molecular Pharmaceutics
The evolution of blood brain barrier permeability changes after stroke, and its implications on clinical outcome: a systematic review and meta-analysis.
Sara Bernardo-Castro; João André Sousa; Martins E; Helena Donato; Nunes CA; d'Almeida OC; Miguel Castelo-Branco; et al, 2023. International journal of stroke : official journal of the International Stroke Society. 2023. https://doi.org/10.1177/17474930231166306 . 10.1177/17474930231166306 . International journal of stroke : official journal of the International Stroke Society
Protein-Nanoparticle Interactions Govern the Interfacial Behavior of Polymeric Nanogels: Study of Protein Corona Formation at the Air/Water Interface.
Federico Traldi; Liu P; Inês Maria Cunha Albino; Ferreira L; Ali Zarbakhsh; Marina Resmini, 2023. International journal of molecular sciences. 2023. https://europepmc.org/articles/PMC9917661 . 10.3390/ijms24032810 . International journal of molecular sciences
Each Cellular Compartment Has a Characteristic Protein Reactive Cysteine Ratio Determining Its Sensitivity to Oxidation
Ricardo Pires das Neves; Mónica Chagoyen; Antonio Martinez-Lorente; Carlos Iñiguez; Ana Calatrava; Juana Calabuig; Francisco J. Iborra, 2023. Antioxidants. 2023. https://doi.org/10.3390/antiox12061274 . 10.3390/antiox12061274 . Antioxidants
Engineering graphene-based electrodes for optical neural stimulation
Artur Filipe Rodrigues; Ana P. M. Tavares; Susana Simões; Rui P. F. F. Silva; Tomás Sobrino; Bruno R. Figueiredo; Goreti Sales; Lino Ferreira, 2023. Nanoscale. 2023. https://doi.org/10.1039/D2NR05256C . 10.1039/D2NR05256C . Nanoscale
(Epi)transcriptomics in cardiovascular and neurological complications of COVID-19.
Jusic A; Stellos K; Ferreira L; Baker AH; Devaux Y, 2022. Journal of molecular and cellular cardiology plus. 2022. https://europepmc.org/articles/PMC9330360 . 10.1016/j.jmccpl.2022.100013 . Journal of molecular and cellular cardiology plus
MicroRNA-124-3p-enriched small extracellular vesicles as a therapeutic approach for Parkinson’s disease
2022. Molecular Therapy. 2022. http://dx.doi.org/10.1016/j.ymthe.2022.06.003 . 10.1016/j.ymthe.2022.06.003 . Molecular Therapy
Antimicrobial peptide-based materials: opportunities and challenges
Akhilesh Rai; Rafaela Ferrão; Paulo Palma; Tatiana Patricio; Paula Parreira; Elsa Anes; Chiara Tonda-Turo; et al, 2022. Journal of Materials Chemistry B. 2022. https://doi.org/10.1039/D1TB02617H . 10.1039/D1TB02617H . Journal of Materials Chemistry B
Reconstruction of tissue-specific genome-scale metabolic models for human cancer stem cells
Barata, Tânia; Vieira, Vítor; Rodrigues, Rúben; Neves, Ricardo Pires das; Rocha, Miguel, 2022. Computers in Biology and Medicine. 142. 2022. http://dx.doi.org/10.1016/j.compbiomed.2021.105177 . 10.1016/j.compbiomed.2021.105177 . Computers in Biology and Medicine
Antimicrobial Peptide-Tether Dressing Able to Enhance Wound Healing by Tissue Contact
Akhilesh Rai; Rafaela Ferrão; Denise Marta; Andreia Vilaça; Miguel Lino; Tiago Rondão; Jian Ji; Artur Paiva; Lino Ferreira, 2022. ACS Applied Materials & Interfaces. 2022. https://doi.org/10.1021/acsami.2c06601 . 10.1021/acsami.2c06601 . ACS Applied Materials & Interfaces
Unraveling the potential of endothelial progenitor cells as a treatment following ischemic stroke.
Custodia A; Ouro A; Sargento-Freitas J; Aramburu-Núñez M; Pías-Peleteiro JM; Pablo Hervella; Rosell A; et al, 2022. Frontiers in neurology. 2022. https://europepmc.org/articles/PMC9492921 . 10.3389/fneur.2022.940682 . Frontiers in neurology
Strategies and challenges for non-viral delivery of non-coding RNAs to the heart.
Vilaça A; de Windt LJ; Hugo Fernandes; Ferreira L, 2022. Trends in molecular medicine. 2022. https://doi.org/10.1016/j.molmed.2022.10.002 . 10.1016/j.molmed.2022.10.002 . Trends in molecular medicine
Efficient spatially targeted gene editing using a near-infrared activatable protein-conjugated nanoparticle for brain applications
Catarina Rebelo; Tiago Reis; Joana Guedes; Cláudia Saraiva; Artur Filipe Rodrigues; Susana Simões; Liliana Bernardino; et al, 2022. Nature Communications. 2022. https://doi.org/10.1038/s41467-022-31791-6 . 10.1038/s41467-022-31791-6 . Nature Communications
A Polymeric Nanoparticle Formulation for Targeted mRNA Delivery to Fibroblasts
Artur Filipe Rodrigues; Catarina Rebelo; Susana Simões; Cristiana Paulo; Sónia Pinho; Vítor Francisco; Lino Ferreira, 2022. Advanced Science. 2022. https://doi.org/10.1002/advs.202205475 . 10.1002/advs.202205475 . Advanced Science
Intercellular transfer of miR-200c-3p impairs the angiogenic capacity of cardiac endothelial cells
2022. Molecular Therapy. 2257 - 2273. 6. 30. 2022. http://dx.doi.org/10.1016/j.ymthe.2022.03.002 . 10.1016/j.ymthe.2022.03.002 . Molecular Therapy
Extracellular vesicles enriched with an endothelial cell pro-survival microRNA affects skin tissue regeneration
2022. Molecular Therapy - Nucleic Acids. 307 - 327. 28. 2022. http://dx.doi.org/10.1016/j.omtn.2022.03.018 . 10.1016/j.omtn.2022.03.018 . Molecular Therapy - Nucleic Acids
Multi-parametric surface plasmon resonance-based intake quantification of label-free light-activated nanoparticles by therapeutic limbal stem cells for corneal blindness
2022. Nano Select. 2022. http://dx.doi.org/10.1002/nano.202200027 . 10.1002/nano.202200027 . Nano Select
A NIR-II emissive polymer AIEgen for imaging-guided photothermal elimination of bacterial infection
2022. Biomaterials. 121579 - 121579. 286. 2022. http://dx.doi.org/10.1016/j.biomaterials.2022.121579 . 10.1016/j.biomaterials.2022.121579 . Biomaterials
Interindividual heterogeneity affects the outcome of human cardiac tissue decellularization
Tenreiro, Miguel F.; Almeida, Henrique V.; Calmeiro, Tomás; Fortunato, Elvira; Ferreira, Lino; Alves, Paula M.; Serra, Margarida, 2021. Scientific Reports. 1. 11. 2021. http://dx.doi.org/10.1038/s41598-021-00226-5 . 10.1038/s41598-021-00226-5 . Scientific Reports
Engineered extracellular vesicles as brain therapeutics
Lino, Miguel M.; Simões, Susana; Tomatis, Francesca; Albino, Inês; Barrera, Angela; Vivien, Denis; Sobrino, Tomas; Ferreira, Lino, 2021. Journal of Controlled Release. 472 - 485. 338. 2021. http://dx.doi.org/10.1016/j.jconrel.2021.08.037 . 10.1016/j.jconrel.2021.08.037 . Journal of Controlled Release
Re-Use of Caco-2 Monolayers in Permeability Assays—Validation Regarding Cell Monolayer Integrity
Pires, Cristiana L.; Praça, Catarina; Martins, Patrícia A. T.; Batista de Carvalho, Ana L. M.; Ferreira, Lino; Marques, Maria Paula M.; Moreno, Maria João, 2021. Pharmaceutics. 10. 13. 2021. http://dx.doi.org/10.3390/pharmaceutics13101563 . 10.3390/pharmaceutics13101563 . Pharmaceutics
Human Extracellular-Matrix Functionalization of 3D hiPSC-Based Cardiac Tissues Improves Cardiomyocyte Maturation
Almeida, Henrique V.; Tenreiro, Miguel F.; Louro, Ana F.; Abecasis, Bernardo; Santinha, Deolinda; Calmeiro, Tomás; Fortunato, Elvira; et al, 2021. ACS Applied Bio Materials. 1888 - 1899. 2. 4. 2021. http://dx.doi.org/10.1021/acsabm.0c01490 . 10.1021/acsabm.0c01490 . ACS Applied Bio Materials
Toxicological Profile of Umbilical Cord Blood-Derived Small Extracellular Vesicles
Rodrigues, Silvia C.; Cardoso, Renato M. S.; Gomes, Claudia F.; Duarte, Filipe V.; Freire, Patricia C.; Neves, Ricardo; Simoes-Correia, Joana, 2021. Membranes. 9. 11. 2021. http://dx.doi.org/10.3390/membranes11090647 . 10.3390/membranes11090647 . Membranes
Therapeutic Nanoparticles for the Different Phases of Ischemic Stroke
Bernardo-Castro, Sara; Albino, Inês; Barrera-Sandoval, Ángela María; Tomatis, Francesca; Sousa, João André; Martins, Emanuel; Simões, Susana; et al, 2021. Life. 6. 11. 2021. http://dx.doi.org/10.3390/life11060482 . 10.3390/life11060482 . Life
Immunomodulatory Properties of Umbilical Cord Blood-Derived Small Extracellular Vesicles and Their Therapeutic Potential for Inflammatory Skin Disorders
Sílvia C. Rodrigues; Renato M. S. Cardoso; Patricia C. Freire; Cláudia F. Gomes; Filipe V. Duarte; Ricardo Pires das Neves; Joana Simões-Correia, 2021. International Journal of Molecular Sciences. 2021. https://doi.org/10.3390/ijms22189797 . 10.3390/ijms22189797 . International Journal of Molecular Sciences
Screening for Colorectal Cancer Leading into a New Decade: The “Roaring ‘20s” for Epigenetic Biomarkers?
Almeida-Lousada, Hélder; Mestre, André; Ramalhete, Sara; Price, Aryeh J.; de Mello, Ramon Andrade; Marreiros, Ana D.; Neves, Ricardo Pires das; Castelo-Branco, Pedro, 2021. Current Oncology. 4874 - 4893. 6. 28. 2021. http://dx.doi.org/10.3390/curroncol28060411 . 10.3390/curroncol28060411 . Current Oncology
Identification of colorectal cancer associated biomarkers: an integrated analysis of miRNA expression
Fonseca, André; Ramalhete, Sara Ventura; Mestre, André; Pires das Neves, Ricardo; Marreiros, Ana; Castelo-Branco, Pedro; Roberto, Vânia Palma, 2021. Aging. 21991 - 22029. 18. 13. 2021. http://dx.doi.org/10.18632/aging.203556 . 10.18632/aging.203556 . Aging
Development of an optimized and scalable method for isolation of umbilical cord blood-derived small extracellular vesicles for future clinical use
Renato M. S. Cardoso; Silvia C. Rodrigues; Claudia F. Gomes; Filipe V. Duarte; Maryse Romao; Ermelindo C. Leal; Patricia C. Freire; Ricardo Neves; Joana Simões-Correia, 2021. STEM CELLS Translational Medicine. 2021. https://doi.org/10.1002/sctm.20-0376 . 10.1002/sctm.20-0376 . STEM CELLS Translational Medicine
Revisiting gene delivery to the brain: silencing and editing
João Conniot; Sepehr Talebian; Susana Simões; Lino Ferreira; João Conde, 2021. Biomaterials Science. 1065 - 1087. 4. 9. 2021. https://doi.org/10.1039/D0BM01278E . 10.1039/D0BM01278E . Biomaterials Science
Biomedical applications of the peptide decorated gold nanoparticles
Rai, Akhilesh; Ferreira, Lino, 2021. Critical Reviews in Biotechnology. 186 - 215. 2. 41. 2021. http://dx.doi.org/10.1080/07388551.2020.1853031 . 10.1080/07388551.2020.1853031 . Critical Reviews in Biotechnology
Induced pluripotent stem cell-derived vascular networks to screen nano–bio interactions
Estronca, Luís; Francisco, Vitor; Pitrez, Patrícia; Honório, Inês; Carvalho, Lara; Vazão, Helena; Blersch, Josephine; et al, 2021. Nanoscale Horizons. 2021. http://dx.doi.org/10.1039/d0nh00550a . 10.1039/d0nh00550a . published Nanoscale Horizons
Exogenous loading of miRNAs into small extracellular vesicles
Abreu, Ricardo C.; Ramos, Cristiana V.; Becher, Clarissa; Lino, Miguel; Jesus, Carlos; Costa Martins, Paula A.; Martins, Patrícia A. T.; et al, 2021. Journal of Extracellular Vesicles. 10. 10. 2021. http://dx.doi.org/10.1002/jev2.12111 . 10.1002/jev2.12111 . Journal of Extracellular Vesicles
High-throughput screening of nanoparticles in drug delivery
Inês Tomé; Vitor Francisco; Hugo Fernandes; Lino Ferreira, 2021. APL Bioengineering. 2021. https://doi.org/10.1063/5.0057204 . 10.1063/5.0057204 . APL Bioengineering
Antimicrobial and pro-angiogenic properties of soluble and nanoparticle-immobilized LL37 peptides
Michela Comune; Akhilesh Rai; Paulo Palma; Chiara TondaTuro; Lino Ferreira, 2021. Biomaterials Science. 2021. https://doi.org/10.1039/D1BM01034D . 10.1039/D1BM01034D . Biomaterials Science
Refinement of a differentiation protocol using neuroblastoma SH-SY5Y cells for use in neurotoxicology research
Rui F. Simões; Rafaela Ferrão; Margarida R. Silva; Sonia L.C. Pinho; Lino Ferreira; Paulo J. Oliveira; Teresa Cunha-Oliveira, 2021. Food and Chemical Toxicology. 111967 - 111967. 149. 2021. https://doi.org/10.1016/j.fct.2021.111967 . 10.1016/j.fct.2021.111967 . Food and Chemical Toxicology
Spatially resolved analysis of FFPE tissue proteomes by quantitative mass spectrometry.
Buczak K; Kirkpatrick JM; Truckenmueller F; Santinha D; Ferreira L; Roessler S; Singer S; Beck M; Ori A, 2020. Nature protocols. 2020. http://europepmc.org/abstract/med/32737464 . 10.1038/s41596-020-0356-y . Nature protocols
A Light-Triggerable Nanoparticle Library for the Controlled Release of Non-Coding RNAs
Blersch, Josephine; Francisco, Vitor; Rebelo, Catarina; Jiménez-Balsa, Adrian; Antunes, Helena; Gonzato, Carlo; Pinto, Sandra; et al, 2020. Angewandte Chemie International Edition. 1985 - 1991. 5. 59. 2020. http://dx.doi.org/10.1002/anie.201911398 . 10.1002/anie.201911398 . Angewandte Chemie International Edition
Native and bioengineered extracellular vesicles for cardiovascular therapeutics.
de Abreu RC; Fernandes H; da Costa Martins PA; Sahoo S; Emanueli C; Ferreira L, 2020. Nature reviews. Cardiology. 2020. http://europepmc.org/abstract/med/32483304 . 10.1038/s41569-020-0389-5 . Nature reviews. Cardiology
Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine
Raquel Ferreira; Joseph Napoli; Tariq Enver; Liliana Bernardino; Lino Ferreira, 2020. Nature Communications. 2020. https://doi.org/10.1038/s41467-020-18042-2 . 10.1038/s41467-020-18042-2 . Nature Communications
Pathophysiology of Blood–Brain Barrier Permeability Throughout the Different Stages of Ischemic Stroke and Its Implication on Hemorrhagic Transformation and Recovery
Bernardo-Castro, Sara; Sousa, João André; Brás, Ana; Cecília, Carla; Rodrigues, Bruno; Almendra, Luciano; Machado, Cristina; et al, 2020. Frontiers in Neurology. 11. 2020. http://dx.doi.org/10.3389/fneur.2020.594672 . 10.3389/fneur.2020.594672 . Frontiers in Neurology
A high-throughput screening platform to identify nanocarriers for efficient delivery of RNA-based therapies
Francisco, Vitor; Rebelo, Catarina; Rodrigues, Artur Filipe; Blersch, Josephine; Fernandes, Hugo; Ferreira, Lino, 2020. Methods. 2020. http://dx.doi.org/10.1016/j.ymeth.2020.12.002 . 10.1016/j.ymeth.2020.12.002 . Methods
Vulnerability of progeroid smooth muscle cells to biomechanical forces is mediated by MMP13.
Pitrez PR; Estronca L; Monteiro LM; Colell G; Vazão H; Santinha D; Harhouri K; et al, 2020. Nature communications. 2020. http://europepmc.org/abstract/med/32807790 . 10.1038/s41467-020-17901-2 . Nature communications
A light-triggerable formulation to control the stability of pro-angiogenic transcription factor hypoxia inducible factor-1a (HIF-1a)
Josephine Blersch; Vitor Francisco; Catarina Rebelo; Adrian Jiménez-Balsa; Helena Antunes; Sandra Pinto; Susana Simões; Akhilesh Rai; Lino Ferreira, 2020. Nanoscale. 2020. https://doi.org/10.1039/C9NR10503D . 10.1039/C9NR10503D . Nanoscale
Permeability of the blood brain barrier through the phases of ischemic stroke and relation with clinical outcome: protocol for a systematic review
Ferreira, Lino, 2020. BMJ Open. 9. 10. 2020. published BMJ Open
Correction to: In vitro mechanistic studies on a-amanitin and its putative antidotes
Daniela Ferreira Rodrigues; Ricardo Pires das Neves; Alexandra T. P. Carvalho; Maria Lourdes Bastos; Vera M. Costa; Félix Carvalho, 2020. Archives of Toxicology. 2020. https://doi.org/10.1007/s00204-020-02735-0 . 10.1007/s00204-020-02735-0 . Archives of Toxicology
In vitro mechanistic studies on a-amanitin and its putative antidotes
Daniela Ferreira Rodrigues; Ricardo Pires das Neves; Alexandra T. P. Carvalho; Maria Lourdes Bastos; Vera M. Costa; Félix Carvalho, 2020. Archives of Toxicology. 2020. https://doi.org/10.1007/s00204-020-02718-1 . 10.1007/s00204-020-02718-1 . Archives of Toxicology
Unveiling the molecular crosstalk in a human induced pluripotent stem cell-derived cardiac model
Bernardo Abecasis; Patrícia Gomes-Alves; Susana Rosa; Pedro J. Gouveia; Lino Ferreira; Margarida Serra; Paula M. Alves, 2019. Biotechnology and Bioengineering. 1245 - 1252. 5. 116. 2019. https://doi.org/10.1002/bit.26929 . 10.1002/bit.26929 . Biotechnology and Bioengineering
A near infrared light-triggerable modular formulation for the delivery of small biomolecules
Ferreira, Lino, 2019. Journal of Nanobiotechnology. 2019. http://dx.doi.org/10.1186/s12951-019-0530-y . 10.1186/s12951-019-0530-y . Journal of Nanobiotechnology
Soft culture substrates favor stem-like cellular phenotype and facilitate reprogramming of human mesenchymal stem/stromal cells (hMSCs) through mechanotransduction
Neves, Ricardo, 2019. Scientific Reports. 2019. http://dx.doi.org/10.1038/s41598-019-45352-3 . 10.1038/s41598-019-45352-3 . Scientific Reports
Bioprocess decision support tool for scalable manufacture of extracellular vesicles
Ferreira, Lino, 2019. Biotechnology and Bioengineering. 2019. http://dx.doi.org/10.1002/bit.26809 . 10.1002/bit.26809 . Biotechnology and Bioengineering
A light-triggerable nanoparticle library for the controlled release of non-coding RNAs.
Ferreira, Lino, 2019. Angewandte Chemie (International ed. in English). 2019. https://doi.org/10.1002/anie.201911398 . 10.1002/anie.201911398 . Angewandte Chemie (International ed. in English)
A High-Throughput Screening Method to Identify Compounds Displaying Human Vascular Embryonic Toxicity
Ferreira, Lino, 2019. Current Protocols in Stem Cell Biology. 2019. http://dx.doi.org/10.1002/cpsc.93 . 10.1002/cpsc.93 . Current Protocols in Stem Cell Biology
Derivation of Brain Capillary-like Endothelial Cells from Human Pluripotent Stem Cell-Derived Endothelial Progenitor Cells.
Ferreira, Lino, 2019. Stem cell reports. 2019. https://europepmc.org/articles/PMC6829749 . 10.1016/j.stemcr.2019.08.002 . Stem cell reports
What human blood-brain barrier models can tell us about BBB function and drug discovery?
Ferreira, Lino, 2019. Expert opinion on drug discovery. 2019. https://doi.org/10.1080/17460441.2019.1646722 . 10.1080/17460441.2019.1646722 . Expert opinion on drug discovery
The Kinetics of Small Extracellular Vesicle Delivery Impacts Skin Tissue Regeneration
Ferreira, Lino, 2019. ACS Nano. 2019. http://dx.doi.org/10.1021/acsnano.9b00376 . 10.1021/acsnano.9b00376 . ACS Nano
A positron-emission tomography (PET)/magnetic resonance imaging (MRI) platform to track in vivo small extracellular vesicles
Arnab Banerjee; Vitor Alves; Tiago Rondão; José Sereno; Ângela Neves; Miguel Lino; Andreia Ribeiro; Antero J. Abrunhosa; Lino S. Ferreira, 2019. Nanoscale. 13243 - 13248. 28. 11. 2019. https://doi.org/10.1039/C9NR02512J . 10.1039/C9NR02512J . Nanoscale
Spatially Confining Surface Roughness on Exponentially Growing Polyelectrolyte Multilayer Films
Ferreira, Lino, 2019. Advanced Materials Interfaces. 2019. http://dx.doi.org/10.1002/admi.201900702 . 10.1002/admi.201900702 . Advanced Materials Interfaces
A photodynamic antibacterial spray-coating based on the host–guest immobilization of the photosensitizer methylene blue
Tian-tian Yao; Jing Wang; Yun-fan Xue; Wei-jiang Yu; Qiang Gao; Lino Ferreira; Ke-Feng Ren; Jian Ji, 2019. Journal of Materials Chemistry B. 2019. https://doi.org/10.1039/C9TB01069F . 10.1039/C9TB01069F . Journal of Materials Chemistry B
Functional characterization of iPSC-derived arterial- and venous-like endothelial cells
Ferreira, Lino, 2019. Scientific Reports. 2019. http://dx.doi.org/10.1038/s41598-019-40417-9 . 10.1038/s41598-019-40417-9 . Scientific Reports
Osmotic modulation of chromatin impacts on efficiency and kinetics of cell fate modulation
Ferreira, Lino, 2018. Scientific Reports. 2018. http://dx.doi.org/10.1038/s41598-018-25517-2 . 10.1038/s41598-018-25517-2 . Scientific Reports
Cooperative Transcription Factor Induction Mediates Hemogenic Reprogramming
Ferreira, Lino, 2018. Cell Reports. 2018. http://dx.doi.org/10.1016/j.celrep.2018.11.032 . 10.1016/j.celrep.2018.11.032 . Cell Reports
A nanoformulation for the preferential accumulation in adult neurogenic niches
Ferreira, Lino, 2018. Journal of Controlled Release. 2018. http://dx.doi.org/10.1016/j.jconrel.2018.06.013 . 10.1016/j.jconrel.2018.06.013 . Journal of Controlled Release
STROKE34 Study Protocol: A Randomized Controlled Phase IIa Trial of Intra-Arterial CD34+ Cells in Acute Ischemic Stroke
Ferreira, Lino, 2018. Frontiers in Neurology. 2018. http://dx.doi.org/10.3389/fneur.2018.00302 . 10.3389/fneur.2018.00302 . Frontiers in Neurology
Intravenous administration of retinoic acid-loaded polymeric nanoparticles prevents ischemic injury in the immature brain
Ferreira, Lino, 2018. Neuroscience Letters. 2018. http://dx.doi.org/10.1016/j.neulet.2018.02.066 . 10.1016/j.neulet.2018.02.066 . Neuroscience Letters
MicroRNA-124-loaded nanoparticles increase survival and neuronal differentiation of neural stem cells in vitro but do not contribute to stroke outcome in vivo
Ferreira, Lino, 2018. PLOS ONE. 2018. http://dx.doi.org/10.1371/journal.pone.0193609 . 10.1371/journal.pone.0193609 . PLOS ONE
Endothelial Progenitor Cells influence acute and subacute stroke hemodynamics
Ferreira, Lino, 2018. Journal of the Neurological Sciences. 2018. http://dx.doi.org/10.1016/j.jns.2017.12.028 . 10.1016/j.jns.2017.12.028 . Journal of the Neurological Sciences
Cecropin-Melittin Functionalized Polyurethane Surfaces Prevent Staphylococcus epidermidis Adhesion without Inducing Platelet Adhesion and Activation
Ferreira, Lino, 2018. Advanced Materials Interfaces. 2018. http://dx.doi.org/10.1002/admi.201801390 . 10.1002/admi.201801390 . Advanced Materials Interfaces
Atomistic-Level Investigation of a LL37-Conjugated Gold Nanoparticle By Well-Tempered Metadynamics
André F. Ferreira; Michela Comune; Akhilesh Rai; Lino Ferreira; Pedro N. Simões, 2018. The Journal of Physical Chemistry B. 2018. https://doi.org/10.1021/acs.jpcb.8b05717 . 10.1021/acs.jpcb.8b05717 . The Journal of Physical Chemistry B
Modulation of Angiogenic Activity by Light-Activatable miRNA-Loaded Nanocarriers
Miguel M. Lino; Susana Simões; Andreia Vilaça; Helena Antunes; Alessandra Zonari; Lino Ferreira, 2018. ACS Nano. 2018. https://doi.org/10.1021/acsnano.7b07538 . 10.1021/acsnano.7b07538 . ACS Nano
Mitochondrial levels determine variability in cell death by modulating apoptotic gene expression
Márquez-Jurado, S.; Díaz-Colunga, J.; Das Neves, R.P.; Martinez-Lorente, A.; Almazán, F.; Guantes, R.; Iborra, F.J., 2018. Nature Communications. 1. 9. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85041107950&partnerID=MN8TOARS . 10.1038/s41467-017-02787-4 . Nature Communications
Stem cells as vehicles and targets of nanoparticles.
Pinho S; Macedo MH; Rebelo C; Sarmento B; Ferreira L, 2018. Drug discovery today. 2018. http://europepmc.org/abstract/med/29337203 . 10.1016/j.drudis.2018.01.030 . Drug discovery today
Validating the RedMIT/GFP-LC3 Mouse Model by Studying Mitophagy in Autosomal Dominant Optic Atrophy Due to the OPA1Q285STOP Mutation
Neves, Ricardo, 2018. Frontiers in Cell and Developmental Biology. 2018. http://dx.doi.org/10.3389/fcell.2018.00103 . 10.3389/fcell.2018.00103 . Frontiers in Cell and Developmental Biology
Nanoparticles Conjugated with Photocleavable Linkers for the Intracellular Delivery of Biomolecules
Adrián Jiménez-Balsa; Sandra Pinto; Emanuel Quartin; Miguel M. Lino; Vitor Francisco; Lino Ferreira, 2018. Bioconjugate Chemistry. 2018. https://doi.org/10.1021/acs.bioconjchem.7b00820 . 10.1021/acs.bioconjchem.7b00820 . Bioconjugate Chemistry
Osmotic modulation of chromatin impacts on efficiency and kinetics of cell fate modulation
Neves, Ricardo, 2018. Scientific Reports. 2018. http://dx.doi.org/10.1038/s41598-018-25517-2 . 10.1038/s41598-018-25517-2 . Scientific Reports
Endothelial progenitor cells enhance blood-brain barrier permeability in subacute stroke.
Sargento-Freitas J; Aday S; Nunes C; Cordeiro M; Gouveia A; Silva F; Machado C; et al, 2018. Neurology. 2018. http://europepmc.org/abstract/med/29237797 . 10.1212/wnl.0000000000004801 . Neurology
Substrate Topography Modulates Cell Aging on a Progeria Cell Model
Patricia R. Pitrez; Luís Estronca; Helena Vazão; Anne-Laure Egesipe; Amélie Le Corf; Claire Navarro; Nicolas Lévy; et al, 2018. ACS Biomaterials Science & Engineering. 2018. https://doi.org/10.1021/acsbiomaterials.8b00224 . 10.1021/acsbiomaterials.8b00224 . ACS Biomaterials Science & Engineering
Light-triggerable formulations for the intracellular controlled release of biomolecules.
Lino MM; Ferreira L, 2018. Drug discovery today. 2018. http://europepmc.org/abstract/med/29326080 . 10.1016/j.drudis.2018.01.019 . Drug discovery today
Intracellular delivery of more than one protein with spatio-temporal control
Miguel M. Lino; Susana Simões; Sónia Pinho; Lino Ferreira; Lino MM; Simões S; Pinho S; Ferreira L, 2017. Nanoscale. 18668 - 18680. 47. 9. 2017. https://doi.org/10.1039/C7NR02414B . 10.1039/C7NR02414B . Nanoscale
Prolonged intracellular accumulation of light-inducible nanoparticles in leukemia cells allows their remote activation
Boto, Carlos; Quartin, Emanuel; Cai, Yijun; Martín-Lorenzo, Alberto; Cenador, María Begoña García; Pinto, Sandra; Gupta, Rajeev; et al, 2017. Nature Communications. 1. 8. 2017. http://dx.doi.org/10.1038/ncomms15204 . 10.1038/ncomms15204 . Nature Communications
Antimicrobial peptide-gold nanoscale therapeutic formulation with high skin regenerative potential.
Comune M; Rai A; Chereddy KK; Pinto S; Aday S; Ferreira AF; Zonari A; et al, 2017. Journal of controlled release : official journal of the Controlled Release Society. 2017. http://europepmc.org/abstract/med/28694030 . 10.1016/j.jconrel.2017.07.007 . Journal of controlled release : official journal of the Controlled Release Society
Findings on the interaction of the antimicrobial peptide cecropin-melittin with a gold surface from molecular dynamics studies
Ferreira, Lino, 2017. European Biophysics Journal. 2017. http://dx.doi.org/10.1007/s00249-016-1160-z . 10.1007/s00249-016-1160-z . European Biophysics Journal
Anti-Inflammatory Strategy for M2 Microglial Polarization Using Retinoic Acid-Loaded Nanoparticles
Ferreira, Lino, 2017. Mediators of Inflammation. 2017. http://dx.doi.org/10.1155/2017/6742427 . 10.1155/2017/6742427 . Mediators of Inflammation
Prolonged intracellular accumulation of light-inducible nanoparticles in leukemia cells allows their remote activation
Boto, C.; Quartin, E.; Cai, Y.; Martín-Lorenzo, A.; Cenador, M.B.G.; Pinto, S.; Gupta, R.; et al, 2017. Nature Communications. 8. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85026559803&partnerID=MN8TOARS . 10.1038/ncomms15204 . Nature Communications
Exosomes secreted by cardiomyocytes subjected to ischaemia promote cardiac angiogenesis.
Ribeiro-Rodrigues TM; Laundos TL; Pereira-Carvalho R; Batista-Almeida D; Pereira R; Coelho-Santos V; Silva AP; et al, 2017. Cardiovascular research. 2017. http://europepmc.org/abstract/med/28859292 . 10.1093/cvr/cvx118 . Cardiovascular research
Erratum: Restoring heart function and electrical integrity: Closing the circuit.
Monteiro LM; Vasques-Nóvoa F; Ferreira L; Pinto-do-Ó P; Nascimento DS, 2017. NPJ Regenerative medicine. 2017. http://europepmc.org/abstract/med/29303158 . 10.1038/s41536-017-0020-5 . NPJ Regenerative medicine
Blue light potentiates neurogenesis induced by retinoic acid-loaded responsive nanoparticles.
Santos T; Ferreira R; Quartin E; Boto C; Saraiva C; Bragança J; Peça J; et al, 2017. Acta biomaterialia. 2017. http://europepmc.org/abstract/med/28673742 . 10.1016/j.actbio.2017.06.044 . Acta biomaterialia
Flexible nanofilms coated with aligned piezoelectric microfibers preserve the contractility of cardiomyocytes.
Gouveia PJ; Rosa S; Ricotti L; Abecasis B; Almeida HV; Monteiro L; Nunes J; et al, 2017. Biomaterials. 2017. http://europepmc.org/abstract/med/28622605 . 10.1016/j.biomaterials.2017.05.048 . Biomaterials
Synthetic microparticles conjugated with VEGF165 improve the survival of endothelial progenitor cells via microRNA-17 inhibition.
Aday S; Zoldan J; Besnier M; Carreto L; Saif J; Fernandes R; Santos T; et al, 2017. Nature communications. 2017. http://europepmc.org/abstract/med/28963481 . 10.1038/s41467-017-00746-7 . Nature communications
High-throughput identification of small molecules that affect human embryonic vascular development.
Vazão H; Rosa S; Barata T; Costa R; Pitrez PR; Honório I; de Vries MR; et al, 2017. Proceedings of the National Academy of Sciences of the United States of America. 2017. http://europepmc.org/abstract/med/28348206 . 10.1073/pnas.1617451114 . Proceedings of the National Academy of Sciences of the United States of America
Biomechanical Strain Exacerbates Inflammation on a Progeria-on-a-Chip Model.
Ribas J; Zhang YS; Pitrez PR; Leijten J; Miscuglio M; Rouwkema J; Dokmeci MR; et al, 2017. Small (Weinheim an der Bergstrasse, Germany). 2017. http://europepmc.org/abstract/med/28211642 . 10.1002/smll.201603737 . Small (Weinheim an der Bergstrasse, Germany)
Challenging the great vascular wall: Can we envision a simple yet comprehensive therapy for stroke?
Machado-Pereira M; Santos T; Ferreira L; Bernardino L; Ferreira R, 2017. Journal of tissue engineering and regenerative medicine. 2017. http://europepmc.org/abstract/med/28182332 . 10.1002/term.2427 . Journal of tissue engineering and regenerative medicine
Restoring heart function and electrical integrity: closing the circuit.
Monteiro LM; Vasques-Nóvoa F; Ferreira L; Pinto-do-Ó P; Nascimento DS, 2017. NPJ Regenerative medicine. 2017. http://europepmc.org/abstract/med/29302345 . 10.1038/s41536-017-0015-2 . NPJ Regenerative medicine
Flexible nanofilms coated with aligned piezoelectric microfibers preserve the contractility of cardiomyocytes
Gouveia, P.J.; Rosa, S.; Ricotti, L.; Abecasis, B.; Almeida, H.V.; Monteiro, L.; Nunes, J.; et al, 2017. Biomaterials. 213 - 228. 139. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85020728965&partnerID=MN8TOARS . 10.1016/j.biomaterials.2017.05.048 . Biomaterials
Traceable microRNA-124 loaded nanoparticles as a new promising therapeutic tool for Parkinson's disease.
Saraiva C; Ferreira L; Bernardino L, 2016. Neurogenesis (Austin, Tex.). 2016. http://europepmc.org/abstract/med/28405588 . 10.1080/23262133.2016.1256855 . Neurogenesis (Austin, Tex.)
Drug screening on Hutchinson Gilford progeria pluripotent stem cells reveals aminopyrimidines as new modulators of farnesylation.
Blondel S; Egesipe AL; Picardi P; Jaskowiak AL; Notarnicola M; Ragot J; Tournois J; et al, 2016. Cell death & disease. 2016. http://europepmc.org/abstract/med/26890144 . 10.1038/cddis.2015.374 . Cell death & disease
Cardiovascular Organ-on-a-Chip Platforms for Drug Discovery and Development
Ferreira, Lino, 2016. Applied In Vitro Toxicology. 2016. http://dx.doi.org/10.1089/aivt.2016.0002 . 10.1089/aivt.2016.0002 . Applied In Vitro Toxicology
Nanoparticle-mediated brain drug delivery: Overcoming blood-brain barrier to treat neurodegenerative diseases.
Saraiva C; Praça C; Ferreira R; Santos T; Ferreira L; Bernardino L, 2016. Journal of controlled release : official journal of the Controlled Release Society. 2016. http://europepmc.org/abstract/med/27208862 . 10.1016/j.jconrel.2016.05.044 . Journal of controlled release : official journal of the Controlled Release Society
High-density antimicrobial peptide coating with broad activity and low cytotoxicity against human cells.
Rai A; Pinto S; Evangelista MB; Gil H; Kallip S; Ferreira MG; Ferreira L, 2016. Acta biomaterialia. 2016. http://europepmc.org/abstract/med/26821340 . 10.1016/j.actbio.2016.01.035 . Acta biomaterialia
Nanomedicine Approaches to Modulate Neural Stem Cells in Brain Repair.
Santos T; Boto C; Saraiva CM; Bernardino L; Ferreira L, 2016. Trends in biotechnology. 2016. http://europepmc.org/abstract/med/26917252 . 10.1016/j.tibtech.2016.02.003 . Trends in biotechnology
Stem Cell-Based Human Blood-Brain Barrier Models for Drug Discovery and Delivery.
Aday S; Cecchelli R; Hallier-Vanuxeem D; Dehouck MP; Ferreira L, 2016. Trends in biotechnology. 2016. http://europepmc.org/abstract/med/26838094 . 10.1016/j.tibtech.2016.01.001 . Trends in biotechnology
Retinoic acid-loaded polymeric nanoparticles enhance vascular regulation of neural stem cell survival and differentiation after ischaemia.
Ferreira R; Fonseca MC; Santos T; Sargento-Freitas J; Tjeng R; Paiva F; Castelo-Branco M; Ferreira LS; Bernardino L, 2016. Nanoscale. 2016. http://europepmc.org/abstract/med/27025400 . 10.1039/c5nr09077f . Nanoscale
High Antimicrobial Activity and Low Human Cell Cytotoxicity of Core-Shell Magnetic Nanoparticles Functionalized with an Antimicrobial Peptide.
Maleki H; Rai A; Pinto S; Evangelista M; Cardoso RM; Paulo C; Carvalheiro T; et al, 2016. ACS applied materials & interfaces. 2016. http://europepmc.org/abstract/med/27074633 . 10.1021/acsami.6b03355 . ACS applied materials & interfaces
MicroRNA-124 loaded nanoparticles enhance brain repair in Parkinson's disease.
Saraiva C; Paiva J; Santos T; Ferreira L; Bernardino L, 2016. Journal of controlled release : official journal of the Controlled Release Society. 2016. http://europepmc.org/abstract/med/27269730 . 10.1016/j.jconrel.2016.06.005 . Journal of controlled release : official journal of the Controlled Release Society
One-step synthesis of high-density peptide-conjugated gold nanoparticles with antimicrobial efficacy in a systemic infection model.
Rai A; Pinto S; Velho TR; Ferreira AF; Moita C; Trivedi U; Evangelista M; et al, 2016. Biomaterials. 2016. http://europepmc.org/abstract/med/26866877 . 10.1016/j.biomaterials.2016.01.051 . Biomaterials
Retinoic acid-loaded polymeric nanoparticles induce neuroprotection in a mouse model for Parkinson's disease.
Esteves M; Cristóvão AC; Saraiva T; Rocha SM; Baltazar G; Ferreira L; Bernardino L, 2015. 2015. http://europepmc.org/abstract/med/25798108 . 10.3389/fnagi.2015.00020 .
Lysophosphatidic acid enhances survival of human CD34(+) cells in ischemic conditions.
Kostic I; Fidalgo-Carvalho I; Aday S; Vazão H; Carvalheiro T; Grãos M; Duarte A; et al, 2015. Scientific reports. 2015. http://europepmc.org/abstract/med/26553339 . 10.1038/srep16406 . Scientific reports
Global variability in gene expression and alternative splicing is modulated by mitochondrial content
Guantes, R.; Rastrojo, A.; Neves, R.; Lima, A.; Aguado, B.; Iborra, F.J., 2015. Genome Research. 633 - 644. 5. 125. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84929660832&partnerID=MN8TOARS . 10.1101/gr.178426.114 . Genome Research
Vascular disease modeling using induced pluripotent stem cells: focus in Hutching-Gilford progeria syndrome.
Pitrez P; Rosa SC; Almeida C; Ferreira L, 2015. 2015. http://europepmc.org/abstract/med/26474704 .
An overview of new translational, clinical and therapeutic perspectives in laminopathies and other nuclear envelope-related diseases. Proceedings of the 1st French-Italian meeting on laminopathies & other nuclear envelope-related diseases
Ferreira, Lino, 2015. Orphanet Journal of Rare Diseases . 2015. 10.1186/1750-1172-10-S2-I1 . Orphanet Journal of Rare Diseases
Development of a SMCs model from HGPS-iPS and proofs of principle.
Ferreira L, 2015. Orphanet journal of rare diseases. 2015. http://europepmc.org/abstract/PMC/PMC4652490 . 10.1186/1750-1172-10-s2-o3 . Orphanet journal of rare diseases
Inflammatory modulation of stem cells by Magnetic Resonance Imaging (MRI)-detectable nanoparticles
Ferreira, Lino, 2014. RSC Adv.. 2014. http://dx.doi.org/10.1039/c4ra04041d . 10.1039/c4ra04041d . RSC Adv.
Interaction of fullerene nanoparticles with biomembranes: From the partition in lipid membranes to effects on mitochondrial bioenergetics
Santos, S.M.; Dinis, A.M.; Peixoto, F.; Ferreira, L.; Jurado, A.S.; Videira, R.A., 2014. Toxicological Sciences. 117 - 129. 1. 138. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84894311599&partnerID=MN8TOARS . 10.1093/toxsci/kft327 . Toxicological Sciences
PLGA nanoparticles loaded with host defense peptide LL37 promote wound healing.
Chereddy KK; Her CH; Comune M; Moia C; Lopes A; Porporato PE; Vanacker J; et al, 2014. 2014. http://europepmc.org/abstract/med/25173841 . 10.1016/j.jconrel.2014.08.016 .
Boron nitride nanotube-mediated stimulation modulates F/G-actin ratio and mechanical properties of human dermal fibroblasts
Ricotti, L.; Das Neves, R.P.; Ciofani, G.; Canale, C.; Nitti, S.; Mattoli, V.; Mazzolai, B.; Ferreira, L.; Menciassi, A., 2014. Journal of Nanoparticle Research. 2. 16. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84894539117&partnerID=MN8TOARS . 10.1007/s11051-014-2247-z . Journal of Nanoparticle Research
A blood-resistant surgical glue for minimally invasive repair of vessels and heart defects
Lang, N.; Pereira, M.J.; Lee, Y.; Friehs, I.; Vasilyev, N.V.; Feins, E.N.; Ablasser, K.; et al, 2014. Science Translational Medicine. 218. 6. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84892553926&partnerID=MN8TOARS . 10.1126/scitranslmed.3006557 . Science Translational Medicine
Boron nitride nanotube-mediated stimulation modulates F/G-actin ratio and mechanical properties of human dermal fibroblasts
Ricotti, L.; Das Neves, R.P.; Ciofani, G.; Canale, C.; Nitti, S.; Mattoli, V.; Mazzolai, B.; Ferreira, L.; Menciassi, A., 2014. Journal of Nanoparticle Research. 2. 16. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84894539117&partnerID=MN8TOARS . 10.1007/s11051-014-2247-z . Journal of Nanoparticle Research
Combined Surface Micropatterning and Reactive Chemistry Maximizes Tissue Adhesion with Minimal Inflammation
Pereira, M.J.N.; Sundback, C.A.; Lang, N.; Cho, W.K.; Pomerantseva, I.; Ouyang, B.; Tao, S.L.; et al, 2014. Advanced Healthcare Materials. 565 - 571. 4. 3. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84898634094&partnerID=MN8TOARS . 10.1002/adhm.201300264 . Advanced Healthcare Materials
A stable and reproducible human blood-brain barrier model derived from hematopoietic stem cells
Cecchelli, R.; Aday, S.; Sevin, E.; Almeida, C.; Culot, M.; Dehouck, L.; Coisne, C.; et al, 2014. PLoS ONE. 6. 9. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903316132&partnerID=MN8TOARS . 10.1371/journal.pone.0099733 . PLoS ONE
Antifungal activity of dental resins containing amphotericin B-conjugated nanoparticles
Lino, M.M.; Paulo, C.S.O.; Vale, A.C.; Vaz, M.F.; Ferreira, L.S., 2013. Dental Materials. 10. 29. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884143064&partnerID=MN8TOARS . 10.1016/j.dental.2013.07.023 . Dental Materials
Efficient pro-survival/angiogenic miRNA delivery by an MRI-detectable nanomaterial
Gomes, R.S.M.; Neves, R.P.D.; Cochlin, L.; Lima, A.; Carvalho, R.; Korpisalo, P.; Dragneva, G.; et al, 2013. ACS Nano. 3362 - 3372. 4. 7. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876588539&partnerID=MN8TOARS . 10.1021/nn400171w . ACS Nano
Differential internalization of amphotericin B - Conjugated nanoparticles in human cells and the expression of heat shock protein 70
Paulo, C.S.O.; Lino, M.M.; Matos, A.A.; Ferreira, L.S., 2013. Biomaterials. 5281 - 5293. 21. 34. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84877046831&partnerID=MN8TOARS . 10.1016/j.biomaterials.2013.03.048 . Biomaterials
A highly tunable biocompatible and multifunctional biodegradable elastomer
Pereira, M.J.N.; Ouyang, B.; Sundback, C.A.; Lang, N.; Friehs, I.; Mureli, S.; Pomerantseva, I.; et al, 2013. Advanced Materials. 1209 - 1215. 8. 25. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874103151&partnerID=MN8TOARS . 10.1002/adma.201203824 . Advanced Materials
Efficient pro-survival/angiogenic miRNA delivery by an MRI-detectable nanomaterial
Gomes, R.S.M.; Neves, R.P.D.; Cochlin, L.; Lima, A.; Carvalho, R.; Korpisalo, P.; Dragneva, G.; et al, 2013. ACS Nano. 3362 - 3372. 4. 7. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876588539&partnerID=MN8TOARS . 10.1021/nn400171w . ACS Nano
Boron Nitride Nanotube-Mediated Stimulation of Cell Co-Culture on Micro-Engineered Hydrogels
Ricotti, L.; Fujie, T.; Vazão, H.; Ciofani, G.; Marotta, R.; Brescia, R.; Filippeschi, C.; et al, 2013. PLoS ONE. 8. 8. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84881503335&partnerID=MN8TOARS . 10.1371/journal.pone.0071707 . PLoS ONE
Histamine modulates microglia function.
Ferreira R; Santos T; Gonçalves J; Baltazar G; Ferreira L; Agasse F; Bernardino L, 2012. 2012. http://europepmc.org/abstract/med/22569158 . 10.1186/1742-2094-9-90 .
Histamine stimulates neurogenesis in the rodent subventricular zone
Bernardino, L.; Eiriz, M.F.; Santos, T.; Xapelli, S.; Grade, S.; Rosa, A.I.; Cortes, L.; et al, 2012. Stem Cells. 773 - 784. 4. 30. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859512101&partnerID=MN8TOARS . 10.1002/stem.1042 . Stem Cells
Polymeric nanoparticles to control the differentiation of neural stem cells in the subventricular zone of the brain
Santos, T.; Ferreira, R.; Maia, J.; Agasse, F.; Xapelli, S.; Cortes, L.; Bragancia, J.; et al, 2012. ACS Nano. 10463 - 10474. 12. 6. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84871596644&partnerID=MN8TOARS . 10.1021/nn304541h . ACS Nano
Proliferation and skeletal myotube formation capability of C2C12 and H9c2 cells on isotropic and anisotropic electrospun nanofibrous PHB scaffolds
Ricotti, L.; Polini, A.; Genchi, G.G.; Ciofani, G.; Iandolo, D.; Vazão, H.; Mattoli, V.; et al, 2012. Biomedical Materials. 3. 7. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860717976&partnerID=MN8TOARS . 10.1088/1748-6041/7/3/035010 . Biomedical Materials
Mitochondrial variability as a source of extrinsic cellular noise
Johnston, I.G.; Gaal, B.; das Neves, R.P.; Enver, T.; Iborra, F.J.; Jones, N.S., 2012. PLoS Computational Biology. 3. 8. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861161954&partnerID=MN8TOARS . 10.1371/journal.pcbi.1002416 . PLoS Computational Biology
Nanoparticles and surfaces presenting antifungal, antibacterial and antiviral properties
Botequim, D.; Maia, J.; Lino, M.M.F.; Lopes, L.M.F.; Simões, P.N.; Ilharco, L.M.; Ferreira, L., 2012. Langmuir. 7646 - 7656. 20. 28. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861396966&partnerID=MN8TOARS . 10.1021/la300948n . Langmuir
VEGF-functionalized dextran has longer intracellular bioactivity than VEGF in endothelial cells
Maia, J.; Vazão, H.; Pedroso, D.C.S.; Jesus, C.S.H.; Brito, R.M.M.; Grãos, M.; Gil, M.H.; Ferreira, L., 2012. Biomacromolecules. 2906 - 2916. 9. 13. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866111153&partnerID=MN8TOARS . 10.1021/bm3009268 . Biomacromolecules
Nanomedicine boosts neurogenesis: New strategies for brain repair
Santos, T.; Maia, J.; Agasse, F.; Xapelli, S.; Ferreira, L.; Bernardino, L., 2012. Integrative Biology (United Kingdom). 973 - 981. 9. 4. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870939373&partnerID=MN8TOARS . 10.1039/c2ib20129a . Integrative Biology (United Kingdom)
Epigenetic engineering to reverse the Parkinson's expression state
Valente, A.X.C.N.; das Neves, R.P.; Oliveira, P.J., 2012. Parkinsonism and Related Disorders. 717 - 721. 6. 18. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862191970&partnerID=MN8TOARS . 10.1016/j.parkreldis.2012.04.018 . Parkinsonism and Related Disorders
Towards the maturation and characterization of smooth muscle cells derived from human embryonic stem cells
Vazão, H.; das Neves, R.P.; Grãos, M.; Ferreira, L., 2011. PLoS ONE. 3. 6. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952523704&partnerID=MN8TOARS . 10.1371/journal.pone.0017771 . PLoS ONE
a-MSH regulates intergenic splicing of MC1R and TUBB3 in human melanocytes
Dalziel, M.; Kolesnichenko, M.; Das Neves, R.P.; Iborra, F.; Goding, C.; Furger, A., 2011. Nucleic Acids Research. 2378 - 2392. 6. 39. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953710861&partnerID=MN8TOARS . 10.1093/nar/gkq1125 . Nucleic Acids Research
Towards the maturation and characterization of smooth muscle cells derived from human embryonic stem cells
Vazão, H.; das Neves, R.P.; Grãos, M.; Ferreira, L., 2011. PLoS ONE. 3. 6. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952523704&partnerID=MN8TOARS . 10.1371/journal.pone.0017771 . PLoS ONE
Sensing the cardiac environment: Exploiting cues for regeneration
Pereira, M.J.N.; Carvalho, I.F.; Karp, J.M.; Ferreira, L.S., 2011. Journal of Cardiovascular Translational Research. 616 - 630. 5. 4. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-81855221996&partnerID=MN8TOARS . 10.1007/s12265-011-9299-6 . Journal of Cardiovascular Translational Research
Three-dimensional biomaterials for the study of human pluripotent stem cells
Kraehenbuehl, T.P.; Langer, R.; Ferreira, L.S., 2011. Nature Methods. 731 - 736. 9. 8. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80052294065&partnerID=MN8TOARS . 10.1038/nmeth.1671 . Nature Methods
Nanoparticles for intracellular-targeted drug delivery
Paulo, C.S.O.; Pires Das Neves, R.; Ferreira, L.S., 2011. Nanotechnology. 49. 22. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-81855212480&partnerID=MN8TOARS . 10.1088/0957-4484/22/49/494002 . Nanotechnology
Controlling the neuronal differentiation of stem cells by the intracellular delivery of retinoic acid-loaded nanoparticles
Maia, J.; Santos, T.; Aday, S.; Agasse, F.; Cortes, L.; Malva, J.O.; Bernardino, L.; Ferreira, L., 2011. ACS Nano. 97 - 106. 1. 5. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955113748&partnerID=MN8TOARS . 10.1021/nn101724r . ACS Nano
Nanoparticles for intracellular-targeted drug delivery
Paulo, C.S.O.; Pires Das Neves, R.; Ferreira, L.S., 2011. Nanotechnology. 49. 22. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-81855212480&partnerID=MN8TOARS . 10.1088/0957-4484/22/49/494002 . Nanotechnology
Human embryonic stem cell-derived microvascular grafts for cardiac tissue preservation after myocardial infarction
Kraehenbuehl, T.P.; Ferreira, L.S.; Hayward, A.M.; Nahrendorf, M.; van der Vlies, A.J.; Vasile, E.; Weissleder, R.; Langer, R.; Hubbell, J.A., 2011. Biomaterials. 1102 - 1109. 4. 32. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-78649446021&partnerID=MN8TOARS . 10.1016/j.biomaterials.2010.10.005 . Biomaterials
Improved survival, vascular differentiation and wound healing potential of stem cells co-cultured with endothelial cells
Pedroso, D.C.S.; Tellechea, A.; Moura, L.; Fidalgo-Carvalho, I.; Duarte, J.; Carvalho, E.; Ferreira, L., 2011. PLoS ONE. 1. 6. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79551528768&partnerID=MN8TOARS . 10.1371/journal.pone.0016114 . PLoS ONE
Connecting variability in global transcription rate to mitochondrial variability
das Neves, R.P.; Jones, N.S.; Andreu, L.; Gupta, R.; Enver, T.; Iborra, F.J., 2010. PLoS Biology. 12. 8. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650442826&partnerID=MN8TOARS . 10.1371/journal.pbio.1000560 . PLoS Biology
Vascular differentiation of human embryonic stem cells in bioactive hydrogel-based scaffolds.
Gerecht, S.; Ferreira, L.S.; Langer, R.; Gerecht S; Ferreira LS; Langer R, 2010. Methods in molecular biology (Clifton, N.J.). 333 - 354. 584. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-75649126900&partnerID=MN8TOARS . 10.1007/978-1-60761-369-5_18 . Methods in molecular biology (Clifton, N.J.)
Isolation, differentiation and characterization of vascular cells derived from human embryonic stem cells.
Levenberg, S.; Ferreira, L.S.; Chen-Konak, L.; Kraehenbuehl, T.P.; Langer, R., 2010. Nature protocols. 1115 - 1126. 6. 5. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956696064&partnerID=MN8TOARS . 10.1038/nprot.2010.31 . Nature protocols
Antifungal nanoparticles and surfaces
Paulo, C.S.O.; Vidal, M.; Ferreira, L.S., 2010. Biomacromolecules. 2810 - 2817. 10. 11. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957868674&partnerID=MN8TOARS . 10.1021/bm100893r . Biomacromolecules
MicroRNA-210 regulates mitochondrial free radical response to hypoxia and krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU
Favaro, E.; Ramachandran, A.; McCormick, R.; Gee, H.; Blancher, C.; Crosby, M.; Devlin, C.; et al, 2010. PLoS ONE. 4. 5. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956402239&partnerID=MN8TOARS . 10.1371/journal.pone.0010345 . PLoS ONE
Stem cell-based therapies for heart regeneration: What did the bench teach us?
Ferreira, L.; Pedroso, D.C.S.; Vazão, H.; Gomes, R.S.M., 2010. Cardiovascular and Hematological Disorders - Drug Targets. 173 - 185. 3. 10. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-78549255903&partnerID=MN8TOARS . Cardiovascular and Hematological Disorders - Drug Targets
Cell-responsive hydrogel for encapsulation of vascular cells
Kraehenbuehl, T.P.; Ferreira, L.S.; Zammaretti, P.; Hubbell, J.A.; Langer, R., 2009. Biomaterials. 4318 - 4324. 26. 30. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-67650596617&partnerID=MN8TOARS . 10.1016/j.biomaterials.2009.04.057 . Biomaterials
Nanoparticles as tools to study and control stem cells
Ferreira, L., 2009. Journal of Cellular Biochemistry. 746 - 752. 4. 108. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-70350435073&partnerID=MN8TOARS . 10.1002/jcb.22303 . Journal of Cellular Biochemistry
Non-leaching surfaces capable of killing microorganisms on contact
Ferreira, L.; Zumbuehl, A., 2009. Journal of Materials Chemistry. 7796 - 7806. 42. 19. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-70350722395&partnerID=MN8TOARS . 10.1039/b905668h . Journal of Materials Chemistry
Association between active genes occurs at nuclear speckles and is modulated by chromatin environment
Brown, J.M.; Green, J.; Das Neves, R.P.; Neves, R.P.D.; Wallace, H.A.C.; Smith, A.J.H.; Hughes, J.; et al, 2008. Chemtracts. 411 - 413. 10. 21. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-66849113444&partnerID=MN8TOARS . 10.1083/jcb.200803174 . Chemtracts
New Opportunities: The Use of Nanotechnologies to Manipulate and Track Stem Cells
Ferreira, L.; Karp, J.M.; Nobre, L.; Langer, R., 2008. Cell Stem Cell. 136 - 146. 2. 3. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-48349135069&partnerID=MN8TOARS . 10.1016/j.stem.2008.07.020 . Cell Stem Cell
A biodegradable and biocompatible gecko-inspired tissue adhesive
Mahdavi, A.; Ferreira, L.; Sundback, C.; Nichol, J.W.; Chan, E.P.; Carter, D.J.D.; Bettinger, C.J.; et al, 2008. Proceedings of the National Academy of Sciences of the United States of America. 2307 - 2312. 7. 105. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-40649128784&partnerID=MN8TOARS . 10.1073/pnas.0712117105 . Proceedings of the National Academy of Sciences of the United States of America
Intracellular delivery of core-shell fluorescent silica nanoparticles
Fuller, J.E.; Zugates, G.T.; Ferreira, L.S.; Ow, H.S.; Nguyen, N.N.; Wiesner, U.B.; Langer, R.S., 2008. Biomaterials. 1526 - 1532. 10. 29. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-38549088954&partnerID=MN8TOARS . 10.1016/j.biomaterials.2007.11.025 . Biomaterials
Human embryoid bodies containing nano- And microparticulate delivery vehicles
Ferreira, L.; Squier, T.; Park, H.; Choe, H.; Kohane, D.S.; Langer, R., 2008. Advanced Materials. 2285 - 2291. 12. 20. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-48349136691&partnerID=MN8TOARS . 10.1002/adma.200702404 . Advanced Materials
Repeated administration of d-amphetamine results in a time-dependent and dose-independent sustained increase in urinary excretion of p-hydroxyamphetamine in mice
Carvalho, F.; Soares, M.E.; Fernandes, E.; Remião, F.; Carvalho, M.; Duarte, J.A.; Pires-das-Neves, R.; Pereira, M.D.L.; Bastos, M.D.L., 2007. Journal of Health Science. 371 - 377. 4. 53. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34547566233&partnerID=MN8TOARS . 10.1248/jhs.53.371 . Journal of Health Science
Antifungal hydrogels
Zumbuehl, A.; Ferreira, L.; Kuhn, D.; Astashkina, A.; Long, L.; Yeo, Y.; Iaconis, T.; et al, 2007. Proceedings of the National Academy of Sciences of the United States of America. 12994 - 12998. 32. 104. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548767010&partnerID=MN8TOARS . 10.1073/pnas.0705250104 . Proceedings of the National Academy of Sciences of the United States of America
Hyaluronic acid hydrogel for controlled self-renewal and differentiation of human embryonic stem cells
Gerecht, S.; Burdick, J.A.; Ferreira, L.S.; Townsend, S.A.; Langer, R.; Vunjak-Novakovic, G., 2007. Proceedings of the National Academy of Sciences of the United States of America. 11298 - 11303. 27. 104. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34547479732&partnerID=MN8TOARS . 10.1073/pnas.0703723104 . Proceedings of the National Academy of Sciences of the United States of America
Bioactive hydrogel scaffolds for controllable vascular differentiation of human embryonic stem cells
Ferreira, L.S.; Gerecht, S.; Fuller, J.; Shieh, H.F.; Vunjak-Novakovic, G.; Langer, R., 2007. Biomaterials. 2706 - 2717. 17. 28. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947253443&partnerID=MN8TOARS . 10.1016/j.biomaterials.2007.01.021 . Biomaterials
Synthesis and characterization of photocurable elastomers from poly(glycerol-co-sebacate)
Nijst, C.L.E.; Bruggeman, J.P.; Karp, J.M.; Ferreira, L.; Zumbuehl, A.; Bettinger, C.J.; Langer, R., 2007. Biomacromolecules. 3067 - 3073. 10. 8. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-35548988907&partnerID=MN8TOARS . 10.1021/bm070423u . Biomacromolecules
Vascular progenitor cells isolated from human embryonic stem cells give rise to endothelial and smooth muscle-like cells and form vascular networks in vivo
Ferreira, L.S.; Gerecht, S.; Shieh, H.F.; Watson, N.; Rupnick, M.A.; Dallabrida, S.M.; Vunjak-Novakovic, G.; Langer, R., 2007. Circulation Research. 286 - 294. 3. 101. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548335261&partnerID=MN8TOARS . 10.1161/CIRCRESAHA.107.150201 . Circulation Research
Co-culture of human embryonic stem cells with murine embryonic fibroblasts on microwell-patterned substrates
Khademhosseini, A.; Ferreira, L.; Blumling III, J.; Yeh, J.; Karp, J.M.; Fukuda, J.; Langer, R., 2006. Biomaterials. 5968 - 5977. 36. 27. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748769776&partnerID=MN8TOARS . 10.1016/j.biomaterials.2006.06.035 . Biomaterials
Structural analysis of dextran-based hydrogels obtained chemoenzymatically
Ferreira, L.; Figueirecio, M.M.; Gil, M.H.; Ramos, M.A., 2006. Journal of Biomedical Materials Research - Part B Applied Biomaterials. 55 - 64. 1. 77. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33645418697&partnerID=MN8TOARS . 10.1002/jbm.b.30394 . Journal of Biomedical Materials Research - Part B Applied Biomaterials
Cultivation of human embryonic stem cells without the embryoid body step enhances osteogenesis in vitro
Karp, J.M.; Ferreira, L.S.; Khademhosseini, A.; Kwon, A.H.; Yeh, J.; Langer, R.S., 2006. Stem Cells. 835 - 843. 4. 24. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745504422&partnerID=MN8TOARS . 10.1634/stemcells.2005-0383 . Stem Cells
Effect of Cr(V) on reproductive organ morphology and sperm parameters: An experimental study in mice
Pereira, M.D.L.; Das Neves, R.P.; Oliveira, H.; Santos, T.M.; De Jesus, J.P., 2005. Environmental Health: A Global Access Science Source. 4. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-23944463762&partnerID=MN8TOARS . 10.1186/1476-069X-4-9 . Environmental Health: A Global Access Science Source
Improving the adhesion of poly(ethylene terephthalate) fibers to poly(hydroxyethyl methacrylate) hydrogels by ozone treatment: Surface characterization and pull-out tests
Ferreira, L.; Evangelista, M.B.; Martins, M.C.L.; Granja, P.L.; Esteves, J.L.; Barbosa, M.A., 2005. Polymer. 9840 - 9850. 23. 46. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-26844540116&partnerID=MN8TOARS . 10.1016/j.polymer.2005.08.033 . Polymer
Synthesis and characterization of new injectable and degradable dextran-based hydrogels
Maia, J.; Ferreira, L.; Carvalho, R.; Ramos, M.A.; Gil, M.H., 2005. Polymer. 9604 - 9614. 23. 46. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-26844528911&partnerID=MN8TOARS . 10.1016/j.polymer.2005.07.089 . Polymer
Biocatalytic synthesis of highly ordered degradable dextran-based hydrogels
Ferreira, L.; Gil, M.H.; Cabrita, A.M.S.; Dordick, J.S., 2005. Biomaterials. 4707 - 4716. 23. 26. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-14844303889&partnerID=MN8TOARS . 10.1016/j.biomaterials.2004.11.051 . Biomaterials
Hypericum androsaemum infusion increases tert-butyl hydroperoxide-induced mice hepatotoxicity in vivo
Valentão, P.; Carvalho, M.; Carvalho, F.; Fernandes, E.; Neves, R.P.D.; Pereira, M.L.; Andrade, P.B.; Seabra, R.M.; Bastos, M.L., 2004. Journal of Ethnopharmacology. 345 - 351. 2-3. 94. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-4344716319&partnerID=MN8TOARS . 10.1016/j.jep.2004.06.012 . Journal of Ethnopharmacology
Biocompatibility of chemoenzymatically derived dextran-acrylate hydrogels
Ferreira, L.; Rafael, A.; Lamghari, M.; Barbosa, M.A.; Gil, M.H.; Cabrita, A.M.S.; Dordick, J.S., 2004. Journal of Biomedical Materials Research - Part A. 584 - 596. 3. 68. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-1342280525&partnerID=MN8TOARS . Journal of Biomedical Materials Research - Part A
Protective activity of hesperidin and lipoic acid against sodium arsenite acute toxicity in mice
Pires Das Neves, R.N.; Carvalho, F.; Carvalho, M.; Fernandes, E.; Soares, E.; Bastos, M.D.L.; Pereira, M.D.L., 2004. Toxicologic Pathology. 527 - 535. 5. 32. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-4544289287&partnerID=MN8TOARS . 10.1080/01926230490502566 . Toxicologic Pathology
Influence of different silica derivatives in the immobilization and stabilization of a Bacillus licheniformis protease (Subtilisin Carlsberg)
Ferreira, L.; Ramos, M.A.; Dordick, J.S.; Gil, M.H., 2003. Journal of Molecular Catalysis B: Enzymatic. 189 - 199. 4-6. 21. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0347297355&partnerID=MN8TOARS . 10.1016/S1381-1177(02)00223-0 . Journal of Molecular Catalysis B: Enzymatic
Biocatalytic polytransesterification of inulin with divinyladipate
Ferreira, L.; Gil, M.H.; Carvalho, R.; Geraldes, C.F.G.C.; Kim, D.-Y.; Dordick, J.S., 2002. Chemistry of Materials. 4009 - 4011. 10. 14. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036799646&partnerID=MN8TOARS . 10.1021/cm020393w . Chemistry of Materials
Effect of 3,4-methylenedioxymethamphetamine ("ecstasy") on body temperature and liver antioxidant status in mice: Influence of ambient temperature
Carvalho, M.; Carvalho, F.; Remião, F.; De Lourdes Pereira, M.; Pires-Das-Neves, R.; De Lourdes Bastos, M., 2002. Archives of Toxicology. 166 - 172. 3. 76. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036214775&partnerID=MN8TOARS . 10.1007/s00204-002-0324-z . Archives of Toxicology
Enzymatic synthesis of dextran-containing hydrogels
Ferreira, L.; Gil, M.H.; Dordick, J.S.; Carvalho, R., 2002. Biomaterials. 3957 - 3967. 19. 23. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036020043&partnerID=MN8TOARS . 10.1016/S0142-9612(02)00132-1 . Biomaterials
Cr(V) involvement in the toxicity pathway of testicular damage
Pereira, M.L.; Santos, T.M.; Pires das Neves, R.; Costa, F.G.; Pedrosa de Jesus, J., 2002. Asian Journal of Andrology. 153 - 155. 2. 4. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035987253&partnerID=MN8TOARS . Asian Journal of Andrology
Comparative histological studies on liver of mice exposed to Cr(VI) and Cr(V) compounds
Pires Das Neves, R.; Santos, T.M.; De Lourdes Pereira, M.; Pedrosa De Jesus, J., 2002. Human and Experimental Toxicology. 365 - 369. 7. 21. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036656032&partnerID=MN8TOARS . 10.1191/0960327102ht243oa . Human and Experimental Toxicology
Exquisite regioselectivity and increased transesterification activity of an immobilized Bacillus subtilis protease
Ferreira, L.; Ramos, M.A.; Gil, M.H.; Dordick, J.S., 2002. Biotechnology Progress. 986 - 993. 5. 18. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036753108&partnerID=MN8TOARS . 10.1021/bp0255457 . Biotechnology Progress
Design of a drug-delivery system based on polyacrylamide hydrogels. Evaluation of structural properties
Ferreira, Lino, 2001. Chemical educator. 2001. http://link.springer.com/article/10.1007%2Fs00897010461a . 10.1007/s00897010461a . Chemical educator
Chromium(VI) induced alterations in mouse spleen cells: A short-term assay
Das Neves, R.P.; Santos, T.M.; Pereira, M.D.L.; De Jesus, J.P., 2001. Cytobios. 27 - 34. 1 SUPPL.. 413. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0348238820&partnerID=MN8TOARS . Cytobios
Evaluation of poly(2-hydroxyethyl methacrylate) gels as drug delivery systems at different pH values
Ferreira, L.; Vidal, M.M.; Gil, M.H., 2000. International Journal of Pharmaceutics. 169 - 180. 2. 194. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033968976&partnerID=MN8TOARS . 10.1016/S0378-5173(99)00375-0 . International Journal of Pharmaceutics
Preparation and characterization of gels based on sucrose modified with glycidyl methacrylate
Ferreira, L.; Vidal, M.M.; Geraldes, C.F.G.C.; Gil, M.H., 2000. Carbohydrate Polymers. 15 - 24. 1. 41. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033908440&partnerID=MN8TOARS . 10.1016/S0144-8617(99)00064-8 . Carbohydrate Polymers
5 200 out of 200 Publications
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