Metabolism, Aging and Disease

MitoBD - Mitochondria in Brain Disorders

Alzheimer disease

Diabetes

Mitochondria

Redox status

Pharmacological and non-pharmacological strategies


Research lines

Exploring the mitochondrial mechanisms underlying type 2 diabetes-associated brain damage

Clarifying the role of oxygen sensing and signaling in the pathophysiology of Alzheimer disease (AD)

Elucidating the role of sexual dimorphism in the predisposition to AD

Evaluating the benefits of mitochondrial modulators in AD

Overview

Our research group aims to elucidate the role of mitochondria-linked mechanisms, hypoxic stress signaling and sex dimorphism in brain changes associated to diabetes and age-related neurodegenerative diseases, particularly Alzheimer disease. We are also interested in studying the preventive and/or therapeutic potential of some pharmacological and non-pharmacological strategies. To achieve our goals, we use several experimental models such as human brain and peripheral blood samples and in vitro and in vivo/ex vivo models of the above-mentioned diseases. In our studies we mainly use biochemistry and cell and molecular biology methods and techniques.

Publications

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Information about journal articles, updated at 05-12-2021, from platform CIÊNCIAVITAE.

Structural and Functional Alterations in Mitochondria-Associated Membranes (MAMs) and in Mitochondria Activate Stress Response Mechanisms in an In Vitro Model of Alzheimer's Disease

Tânia Fernandes; Rosa Resende; Diana F. Silva; Ana P. Marques; Armanda E. Santos; Sandra M. Cardoso; M. Rosário Domingues; Paula I. Moreira; Cláudia F. Pereira, 2021. Biomedicines. 881 - 881. 8. 9. 2021. https://doi.org/10.3390/biomedicines9080881 . 10.3390/biomedicines9080881 . Biomedicines

Intermittent Hypoxic Conditioning Rescues Cognition and Mitochondrial Bioenergetic Profile in the Triple Transgenic Mouse Model of Alzheimer's Disease

Sónia C. Correia; Nuno J. Machado; Marco G. Alves; Pedro F. Oliveira; Paula I. Moreira, 2021. International Journal of Molecular Sciences. 461 - 461. 1. 22. 2021. https://doi.org/10.3390/ijms22010461 . 10.3390/ijms22010461 . International Journal of Molecular Sciences

IGF1R Deficiency Modulates Brain Signaling Pathways and Disturbs Mitochondria and Redox Homeostasis

Susana Cardoso; Icíar López; Sergio Piñeiro-Hermida; José Pichel; Paula Moreira, 2021. Biomedicines. 158 - 158. 2. 9. 2021. https://doi.org/10.3390/biomedicines9020158 . 10.3390/biomedicines9020158 . Biomedicines

WWOX: A New Therapeutic Target In Type 2 Diabetes-Associated Neurodegeneration

Carvalho, Cristina; Moreira, Paula I., 2021. Metabolism. 116. 2021. http://dx.doi.org/10.1016/j.metabol.2020.154616 . 10.1016/j.metabol.2020.154616 . Metabolism

Oxygen Sensing and Signaling in Alzheimer's Disease: A Breathtaking Story!

Sónia C. Correia; Paula I. Moreira, 2021. Cellular and Molecular Neurobiology. 2021. https://doi.org/10.1007/s10571-021-01148-6 . 10.1007/s10571-021-01148-6 . Cellular and Molecular Neurobiology

Longitudinal normative OCT retinal thickness data for wild-type mice, and characterization of changes in the 3×Tg-AD mice model of Alzheimer's disease

Ferreira, Hugo; Martins, João; Moreira, Paula I.; Ambrósio, António Francisco; Castelo-Branco, Miguel; Serranho, Pedro; Bernardes, Rui, 2021. Aging. 2021. http://dx.doi.org/10.18632/aging.202916 . 10.18632/aging.202916 . Aging

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

Klionsky, Daniel J.; Abdel-Aziz, Amal Kamal; Abdelfatah, Sara; Abdellatif, Mahmoud; Abdoli, Asghar; Abel, Steffen; Abeliovich, Hagai; et al, 2021. Autophagy. 1 - 382. 1. 17. 2021. http://dx.doi.org/10.1080/15548627.2020.1797280 . 10.1080/15548627.2020.1797280 . Autophagy

Retina and Brain Display Early and Differential Molecular and Cellular Changes in the 3xTg-AD Mouse Model of Alzheimer's Disease

Rodrigues-Neves, Ana Catarina; Carecho, Rafael; Correia, Sónia Catarina; Carvalho, Cristina; Campos, Elisa Julião; Baptista, Filipa Isabel; Moreira, Paula Isabel; Ambrósio, António Francisco, 2021. Molecular Neurobiology. 2021. http://dx.doi.org/10.1007/s12035-021-02316-x . 10.1007/s12035-021-02316-x . Molecular Neurobiology

Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing

Cunnane, Stephen C.; Trushina, Eugenia; Morland, Cecilie; Prigione, Alessandro; Casadesus, Gemma; Andrews, Zane B.; Beal, M. Flint; et al, 2020. Nature Reviews Drug Discovery. 2020. http://dx.doi.org/10.1038/s41573-020-0072-x . 10.1038/s41573-020-0072-x . Nature Reviews Drug Discovery

The interplay between redox signalling and proteostasis in neurodegeneration: In vivo effects of a mitochondria-targeted antioxidant in Huntington's disease mice

Pinho, Brígida R.; Duarte, Ana I.; Canas, Paula M.; Moreira, Paula I.; Murphy, Michael P.; Oliveira, Jorge M.A., 2020. Free Radical Biology and Medicine. 372 - 382. 146. 2020. http://dx.doi.org/10.1016/j.freeradbiomed.2019.11.021 . 10.1016/j.freeradbiomed.2019.11.021 . Free Radical Biology and Medicine

PINK1/PARKIN signalling in neurodegeneration and neuroinflammation

Quinn, Peter M. J.; Moreira, Paula I.; Ambrósio, António Francisco; Alves, C. Henrique, 2020. Acta Neuropathologica Communications. 1. 8. 2020. http://dx.doi.org/10.1186/s40478-020-01062-w . 10.1186/s40478-020-01062-w . published Acta Neuropathologica Communications

Liraglutide Protects Against Brain Amyloid-ß1-42 Accumulation in Female Mice with Early Alzheimer's Disease-Like Pathology by Partially Rescuing Oxidative/Nitrosative Stress and Inflammation

Ana I. Duarte; Emanuel Candeias; Inês N. Alves; Débora Mena; Daniela F. Silva; Nuno J. Machado; Elisa J. Campos; et al, 2020. International Journal of Molecular Sciences. 2020. https://doi.org/10.3390/ijms21051746 . 10.3390/ijms21051746 . International Journal of Molecular Sciences

Associations between Trace Elements and Cognitive Decline: An Exploratory 5-Year Follow-Up Study of an Elderly Cohort

Bianca Gerardo; Marina Cabral Pinto; Joana Nogueira; Paula Pinto; Agostinho Almeida; Edgar Pinto; Paula Marinho-Reis; et al, 2020. International Journal of Environmental Research and Public Health. 2020. https://doi.org/10.3390/ijerph17176051 . 10.3390/ijerph17176051 . International Journal of Environmental Research and Public Health

Mitochondria, endoplasmic reticulum and innate immune dysfunction in mood disorders: Do Mitochondria-Associated Membranes (MAMs) play a role?

Resende, R.; Fernandes, T.; Pereira, A.C.; De Pascale, J.; Marques, A.P.; Oliveira, P.; Morais, S.; et al, 2020. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 6. 1866. 2020. http://dx.doi.org/10.1016/j.bbadis.2020.165752 . 10.1016/j.bbadis.2020.165752 . Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Combining Virtual Screening Protocol and In Vitro Evaluation towards the Discovery of BACE1 Inhibitors

Coimbra, Judite R. M.; Baptista, Salete J.; Dinis, Teresa C. P.; Silva, Maria M. C.; Moreira, Paula I.; Santos, Armanda E.; Salvador, Jorge A. R., 2020. Biomolecules. 4. 10. 2020. http://dx.doi.org/10.3390/biom10040535 . 10.3390/biom10040535 . Biomolecules

Characterization of the retinal changes of the 3×Tg-AD mouse model of Alzheimer's disease

Ferreira, Hugo; Martins, João; Nunes, Ana; Moreira, Paula I.; Castelo-Branco, Miguel; Ambrósio, António Francisco; Serranho, Pedro; Bernardes, Rui, 2020. Health and Technology. 2020. http://dx.doi.org/10.1007/s12553-020-00413-w . 10.1007/s12553-020-00413-w . Health and Technology

Is Alzheimer's disease an inflammasomopathy?

Pereira, Claudia F.; Santos, Armanda E.; Moreira, Paula I.; Pereira, Ana Catarina; Sousa, Fabio J.; Cardoso, Sandra M.; Cruz, M. Teresa, 2019. Ageing Research Reviews. 56. 2019. http://dx.doi.org/10.1016/j.arr.2019.100966 . 10.1016/j.arr.2019.100966 . Ageing Research Reviews

An overview of glutaminyl cyclase inhibitors for Alzheimer’s disease

Coimbra, Judite RM; Sobral, Pedro JM; Santos, Armanda E; Moreira, Paula I; Salvador, Jorge AR, 2019. Future Medicinal Chemistry. 3179 - 3194. 24. 11. 2019. http://dx.doi.org/10.4155/fmc-2019-0163 . 10.4155/fmc-2019-0163 . Future Medicinal Chemistry

Post-translational modifications in brain health and disease

Correia, Sónia C.; Carvalho, Cristina; Cardoso, Susana; Moreira, Paula I., 2019. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1947 - 1948. 8. 1865. 2019. http://dx.doi.org/10.1016/j.bbadis.2019.05.006 . 10.1016/j.bbadis.2019.05.006 . Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Links between Cognitive Status and Trace Element Levels in Hair for an Environmentally Exposed Population: A Case Study in the Surroundings of the Estarreja Industrial Area

Cabral Pinto, Marina M. S.; Marinho-Reis, Paula; Almeida, Agostinho; Pinto, Edgar; Neves, Orquídia; Inácio, Manuela; Gerardo, Bianca; et al, 2019. International Journal of Environmental Research and Public Health. 22. 16. 2019. http://dx.doi.org/10.3390/ijerph16224560 . 10.3390/ijerph16224560 . International Journal of Environmental Research and Public Health

Tortuous Paths of Insulin Signaling and Mitochondria in Alzheimer's Disease.

Moreira, PI, 2019. Advances in experimental medicine and biology. 2019. https://doi.org/10.1007/978-981-13-3540-2_9 . 10.1007/978-981-13-3540-2_9 . Advances in experimental medicine and biology

Retinal thinning of inner sub-layers is associated with cortical atrophy in a mouse model of Alzheimer's disease: a longitudinal multimodal in vivo study

Chiquita, Samuel; Campos, Elisa J.; Castelhano, João; Ribeiro, Mário; Sereno, José; Moreira, Paula I.; Castelo-Branco, Miguel; Ambrósio, António Francisco, 2019. Alzheimer's Research & Therapy. 1. 11. 2019. http://dx.doi.org/10.1186/s13195-019-0542-8 . 10.1186/s13195-019-0542-8 . Alzheimer's Research & Therapy

Diabesity and brain disturbances: A metabolic perspective

Susana Cardoso; Paula I. Moreira, 2019. Molecular Aspects of Medicine. 71 - 79. 66. 2019. https://doi.org/10.1016/j.mam.2018.10.002 . 10.1016/j.mam.2018.10.002 . Molecular Aspects of Medicine

A longitudinal multimodal in vivo molecular imaging study of the 3xTg-AD mouse model shows progressive early hippocampal and taurine loss

Chiquita, Samuel; Ribeiro, Mário; Castelhano, João; Oliveira, Francisco; Sereno, José; Batista, Marta; Abrunhosa, Antero; et al, 2019. Human Molecular Genetics. 2174 - 2188. 13. 28. 2019. http://dx.doi.org/10.1093/hmg/ddz045 . 10.1093/hmg/ddz045 . Human Molecular Genetics

The Retina as a Window or Mirror of the Brain Changes Detected in Alzheimer's Disease: Critical Aspects to Unravel

Chiquita, Samuel; Rodrigues-Neves, Ana C.; Baptista, Filipa I.; Carecho, Rafael; Moreira, Paula I.; Castelo-Branco, Miguel; Ambrósio, António F., 2019. Molecular Neurobiology. 5416 - 5435. 8. 56. 2019. http://dx.doi.org/10.1007/s12035-018-1461-6 . 10.1007/s12035-018-1461-6 . Molecular Neurobiology

Diminished O-GlcNAcylation in Alzheimer's disease is strongly correlated with mitochondrial anomalies

Pinho, Tiffany S.; Correia, Sónia C.; Perry, George; Ambrósio, António Francisco; Moreira, Paula I., 2019. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2048 - 2059. 8. 1865. 2019. http://dx.doi.org/10.1016/j.bbadis.2018.10.037 . 10.1016/j.bbadis.2018.10.037 . Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Retinal thickness of the triple-transgenic mice model of Alzheimer's disease at the age of one month

Bernardes, Rui; Ferreira, Hugo; Martins, João; Moreira, Paula I.; Castelo-Branco, Miguel; Ambrósio, António F.; Serranho, Pedro, 2019. Acta Ophthalmologica. S263. 97. 2019. http://dx.doi.org/10.1111/j.1755-3768.2019.5467 . 10.1111/j.1755-3768.2019.5467 . Acta Ophthalmologica

Can the retina show similar molecular and cellular changes as the brain in an animal model of Alzheimer's disease?

Rodrigues-Neves, Ana Catarina; Carecho, Rafael; Baptista, Filipa; Moreira, Paula; Ambrósio, António, 2019. Frontiers in Cellular Neuroscience. 13. 2019. http://dx.doi.org/10.3389/conf.fncel.2019.01.00020 . 10.3389/conf.fncel.2019.01.00020 . Frontiers in Cellular Neuroscience

O-GlcNAcylation and neuronal energy status: Implications for Alzheimer's disease

Tiffany S. Pinho; Diogo M. Verde; Sónia C. Correia; Susana M. Cardoso; Paula I. Moreira, 2018. Ageing Research Reviews. 32 - 41. 46. 2018. https://doi.org/10.1016/j.arr.2018.05.003 . 10.1016/j.arr.2018.05.003 . Ageing Research Reviews

The beneficial role of exercise in mitigating doxorubicin-induced Mitochondrionopathy

Marques-Aleixo, I.; Santos-Alves, E.; Oliveira, P.J.; Moreira, P.I.; Magalhães, J.; Ascensão, A., 2018. Biochimica et Biophysica Acta - Reviews on Cancer. 189 - 199. 2. 1869. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85041805508&partnerID=MN8TOARS . 10.1016/j.bbcan.2018.01.002 . Biochimica et Biophysica Acta - Reviews on Cancer

Sweet Mitochondria: A Shortcut to Alzheimer's Disease

Moreira, P.I., 2018. Journal of Alzheimer's Disease. 1391 - 1401. 3. 62. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85044360897&partnerID=MN8TOARS . 10.3233/JAD-170931 . Journal of Alzheimer's Disease

Beneficial effects of white wine polyphenols-enriched diet on Alzheimer's disease-like pathology

Mendes, D.; Oliveira, M.M.; Moreira, P.I.; Coutinho, J.; Nunes, F.M.; Pereira, D.M.; Valentão, P.; Andrade, P.B.; Videira, R.A., 2018. Journal of Nutritional Biochemistry. 165 - 177. 55. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85043298266&partnerID=MN8TOARS . 10.1016/j.jnutbio.2018.02.001 . Journal of Nutritional Biochemistry

Brain insulin signalling, glucose metabolism and females' reproductive aging: A dangerous triad in Alzheimer's disease

Duarte, A.I.; Santos, M.S.; Oliveira, C.R.; Moreira, P.I., 2018. Neuropharmacology. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85044268663&partnerID=MN8TOARS . 10.1016/j.neuropharm.2018.01.044 . Neuropharmacology

Dual Therapy with Liraglutide and Ghrelin Promotes Brain and Peripheral Energy Metabolism in the R6/2 Mouse Model of Huntington's Disease

Ana I. Duarte; Marie Sjögren; Maria S. Santos; Catarina R. Oliveira; Paula I. Moreira; Maria Björkqvist, 2018. Scientific Reports. 1. 8. 2018. https://doi.org/10.1038/s41598-018-27121-w . 10.1038/s41598-018-27121-w . Scientific Reports

Fingernail Trace Element Content in Environmentally Exposed Individuals and Its Influence on Their Cognitive Status in Ageing

Cabral Pinto, Marina M. S.; Marinho-Reis, A. Paula; Almeida, Agostinho; Freitas, Sandra; Simões, Mário R.; Diniz, M. Luísa; Pinto, Edgar; et al, 2018. Exposure and Health. 181 - 194. 3. 11. 2018. http://dx.doi.org/10.1007/s12403-018-0274-1 . 10.1007/s12403-018-0274-1 . Exposure and Health

Mitochondria as a target for neuroprotection: implications for Alzheimer´s disease

Cardoso, S.; Seiça, R.M.; Moreira, P.I., 2017. Expert Review of Neurotherapeutics. 77 - 91. 1. 17. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85003782022&partnerID=MN8TOARS . 10.1080/14737175.2016.1205488 . Expert Review of Neurotherapeutics

Phosphatase 2A Inhibition Affects Endoplasmic Reticulum and Mitochondria Homeostasis Via Cytoskeletal Alterations in Brain Endothelial Cells

Ana I. Plácido; Cláudia M. F. Pereira; Sónia C. Correira; Cristina Carvalho; Catarina R. Oliveira; Paula I. Moreira, 2017. Molecular Neurobiology. 2017. http://dx.doi.org/10.1007/s12035-015-9640-1 . 10.1007/s12035-015-9640-1 . Molecular Neurobiology

Uncoupling Protein 2 Inhibition Exacerbates Glucose Fluctuation-Mediated Neuronal Effects

Cardoso, S.; Seiça, R.M.; Moreira, P.I., 2017. Neurotoxicity Research. 1 - 14. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85028984223&partnerID=MN8TOARS . 10.1007/s12640-017-9805-y . Neurotoxicity Research

Insights into the human brain proteome: Disclosing the biological meaning of protein networks in cerebrospinal fluid

Bastos, P.; Ferreira, R.; Manadas, B.; Moreira, P.I.; Vitorino, R., 2017. Critical Reviews in Clinical Laboratory Sciences. 185 - 204. 3. 54. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85019117156&partnerID=MN8TOARS . 10.1080/10408363.2017.1299682 . Critical Reviews in Clinical Laboratory Sciences

Selenoprotein S Reduces Endoplasmic Reticulum Stress-Induced Phosphorylation of Tau: Potential Role in Selenate Mitigation of Tau Pathology

Rueli, R.H.L.H.; Torres, D.J.; Dewing, A.S.T.; Kiyohara, A.C.; Barayuga, S.M.; Bellinger, M.T.; Uyehara-Lock, J.H.; et al, 2017. Journal of Alzheimer's Disease. 749 - 762. 2. 55. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-84999116043&partnerID=MN8TOARS . 10.3233/JAD-151208 . Journal of Alzheimer's Disease

Human predisposition to cognitive impairment and its relation with environmental exposure to potentially toxic elements

Cabral Pinto, M.M.S.; Marinho-Reis, A.P.; Almeida, A.; Ordens, C.M.; Silva, M.M.V.G.; Freitas, S.; Simões, M.R.; et al, 2017. Environmental Geochemistry and Health. 1 - 18. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85014615707&partnerID=MN8TOARS . 10.1007/s10653-017-9928-3 . Environmental Geochemistry and Health

Brain GLP-1/IGF-1 Signaling and Autophagy Mediate Exendin-4 Protection Against Apoptosis in Type 2 Diabetic Rats

Candeias, Emanuel; Sebastião, Inês; Cardoso, Susana; Carvalho, Cristina; Santos, Maria Sancha; Oliveira, Catarina Resende; Moreira, Paula I.; Duarte, Ana I., 2017. Molecular Neurobiology. 2017. http://dx.doi.org/10.1007/s12035-017-0622-3 . 10.1007/s12035-017-0622-3 . Molecular Neurobiology

Alzheimer's Disease: From Mitochondrial Perturbations to Mitochondrial Medicine

Cardoso, S.; Carvalho, C.; Correia, S.C.; Seiça, R.M.; Moreira, P.I., 2016. Brain Pathology. 632 - 647. 5. 26. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84988642816&partnerID=MN8TOARS . 10.1111/bpa.12402 . Brain Pathology

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Klionsky, D.J.; Abdelmohsen, K.; Abe, A.; Abedin, M.J.; Abeliovich, H.; Arozena, A.A.; Adachi, H.; et al, 2016. Autophagy. 1 - 222. 1. 12. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-85013763791&partnerID=MN8TOARS . 10.1080/15548627.2015.1100356 . Autophagy

Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

Klionsky, D.J.; Abeliovich, H.; Agostinis, P.; Agrawal, D.K.; Aliev, G.; Askew, D.S.; Baba, M.; et al, 2016. Autophagy. 2. 12. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84975859238&partnerID=MN8TOARS . 10.1080/15548627.2016.1147886 . Autophagy

Mitochondrial traffic jams in Alzheimer's disease - pinpointing the roadblocks

Correia, S.C.; Perry, G.; Moreira, P.I., 2016. Biochimica et Biophysica Acta - Molecular Basis of Disease. 1909 - 1917. 10. 1862. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84979699672&partnerID=MN8TOARS . 10.1016/j.bbadis.2016.07.010 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Middle-Aged Diabetic Females and Males Present Distinct Susceptibility to Alzheimer Disease-like Pathology

Candeias, E.; Duarte, A.I.; Sebastião, I.; Fernandes, M.A.; Plácido, A.I.; Carvalho, C.; Correia, S.; et al, 2016. Molecular Neurobiology. 1 - 19. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84991075553&partnerID=MN8TOARS . 10.1007/s12035-016-0155-1 . Molecular Neurobiology

Physical exercise mitigates doxorubicin-induced brain cortex and cerebellum mitochondrial alterations and cellular quality control signaling

Marques-Aleixo, I.; Santos-Alves, E.; Balça, M.M.; Moreira, P.I.; Oliveira, P.J.; Magalhães, J.; Ascensão, A., 2016. Mitochondrion. 43 - 57. 26. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84949871382&partnerID=MN8TOARS . 10.1016/j.mito.2015.12.002 . Mitochondrion

Physical exercise improves brain cortex and cerebellum mitochondrial bioenergetics and alters apoptotic, dynamic and auto(mito)phagy markers

Marques-Aleixo, I.; Santos-Alves, E.; Balça, M.M.; Rizo-Roca, D.; Moreira, P.I.; Oliveira, P.J.; Magalhães, J.; Ascensão, A., 2015. Neuroscience. 480 - 495. 301. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84947795323&partnerID=MN8TOARS . 10.1016/j.neuroscience.2015.06.027 . Neuroscience

Modulation of endoplasmic reticulum stress: An opportunity to prevent neurodegeneration?

Plácido, A.I.; Pereira, C.M.F.; Duarte, A.I.; Candeias, E.; Correia, S.C.; Carvalho, C.; Cardoso, S.; Oliveira, C.R.; Moreira, P.I., 2015. CNS and Neurological Disorders - Drug Targets. 518 - 533. 4. 14. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84929628537&partnerID=MN8TOARS . CNS and Neurological Disorders - Drug Targets

Metabolic fingerprints in testicular biopsies from type 1 diabetic patients

Alves, M.G.; Martins, A.D.; Moreira, P.I.; Carvalho, R.A.; Sousa, M.; Barros, A.; Silva, J.; et al, 2015. Cell and Tissue Research. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930607586&partnerID=MN8TOARS . 10.1007/s00441-015-2217-5 . Cell and Tissue Research

Testosterone deficiency induced by progressive stages of diabetes mellitus impairs glucose metabolism and favors glycogenesis in mature rat Sertoli cells

Rato, L.; Alves, M.G.; Duarte, A.I.; Santos, M.S.; Moreira, P.I.; Cavaco, J.E.; Oliveira, P.F., 2015. International Journal of Biochemistry and Cell Biology. 1 - 10. 66. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84936877372&partnerID=MN8TOARS . 10.1016/j.biocel.2015.07.001 . International Journal of Biochemistry and Cell Biology

The role of mitochondrial disturbances in Alzheimer, Parkinson and Huntington diseases

Carvalho, C.; Correia, S.C.; Cardoso, S.; Plácido, A.I.; Candeias, E.; Duarte, A.I.; Moreira, P.I., 2015. Expert Review of Neurotherapeutics. 867 - 884. 8. 15. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937838385&partnerID=MN8TOARS . 10.1586/14737175.2015.1058160 . Expert Review of Neurotherapeutics

Kaurane diterpenes as mitochondrial alterations preventive agents under experimental oxidative stress conditions

González-Burgos, E.; Duarte, A.I.; Carretero, M.E.; Moreira, P.I.; Gómez-Serranillos, M.P., 2015. Pharmaceutical Biology. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84945231706&partnerID=MN8TOARS . 10.3109/13880209.2015.1072829 . Pharmaceutical Biology

Alzheimer's disease and type 2 diabetes-related alterations in brain mitochondria, autophagy and synaptic markers

Carvalho, C.; Santos, M.S.; Oliveira, C.R.; Moreira, P.I., 2015. Biochimica et Biophysica Acta - Molecular Basis of Disease. 1665 - 1675. 8. 1852. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84929430489&partnerID=MN8TOARS . 10.1016/j.bbadis.2015.05.001 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Type 2 diabetes aggravates alzheimer's disease-associated vascular alterations of the aorta in mice

Sena, C.M.; Pereira, A.M.; Carvalho, C.; Fernandes, R.; Seiça, R.M.; Oliveira, C.R.; Moreira, P.I., 2015. Journal of Alzheimer's Disease. 127 - 138. 1. 45. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84924181831&partnerID=MN8TOARS . 10.3233/JAD-141008 . Journal of Alzheimer's Disease

Alzheimer's disease-related misfolded proteins and dysfunctional organelles on autophagy menu

Correia, S.C.; Resende, R.; Moreira, P.I.; Pereira, C.M., 2015. DNA and Cell Biology. 261 - 273. 4. 34. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84926636149&partnerID=MN8TOARS . 10.1089/dna.2014.2757 . DNA and Cell Biology

Age-dependent biochemical dysfunction in skeletal muscle of triple-transgenic mouse model of Alzheimer's disease

Monteiro-Cardoso, V.F.; Castro, M.; Oliveira, M.M.; Moreira, P.I.; Peixoto, F.; Videira, R.A., 2015. Current Alzheimer Research. 100 - 115. 2. 12. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84924862255&partnerID=MN8TOARS . Current Alzheimer Research

Cerebrovascular and mitochondrial abnormalities in Alzheimer’s disease: a brief overview

Carvalho, C.; Correia, S.C.; Perry, G.; Castellani, R.J.; Moreira, P.I., 2015. Journal of Neural Transmission. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84922386380&partnerID=MN8TOARS . 10.1007/s00702-015-1367-7 . Journal of Neural Transmission

Daily consumption of white tea (Camellia sinensis (L.)) improves the cerebral cortex metabolic and oxidative profile in prediabetic Wistar rats

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Increased susceptibility to amyloid-ß toxicity in rat brain microvascular endothelial cells under hyperglycemic conditions

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Amyloid-Beta Disrupts Calcium and Redox Homeostasis in Brain Endothelial Cells

Fonseca, A.C.R.G.; Moreira, P.I.; Oliveira, C.R.; Cardoso, S.M.; Pinton, P.; Pereira, C.F., 2014. Molecular Neurobiology. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901537197&partnerID=MN8TOARS . 10.1007/s12035-014-8740-7 . Molecular Neurobiology

Mitochondrial quality control systems sustain brain mitochondrial bioenergetics in early stages of type 2 diabetes

Santos, R.X.; Correia, S.C.; Alves, M.G.; Oliveira, P.F.; Cardoso, S.; Carvalho, C.; Seiça, R.; Santos, M.S.; Moreira, P.I., 2014. Molecular and Cellular Biochemistry. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901561690&partnerID=MN8TOARS . 10.1007/s11010-014-2076-5 . Molecular and Cellular Biochemistry

Insulin as a bridge between type 2 diabetes and alzheimer disease - how anti-diabetics could be a solution for dementia

Sebastião, I.; Candeias, E.; Santos, M.S.; de Oliveira, C.R.; Moreira, P.I.; Duarte, A.I., 2014. Frontiers in Endocrinology. JUL. 5. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84905437740&partnerID=MN8TOARS . 10.3389/fendo.2014.00110 . Frontiers in Endocrinology

Metformin in the diabetic brain: friend or foe?

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Cardiolipin profile changes are associated to the early synaptic mitochondrial dysfunction in Alzheimer's disease

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Vascular, oxidative, and synaptosomal abnormalities during aging and the progression of type 2 diabetes

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Perspectives on mitochondrial uncoupling proteins-mediated neuroprotection

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Pre-diabetes alters testicular PGC1-a/SIRT3 axis modulating mitochondrial bioenergetics and oxidative stress

Rato, L.; Duarte, A.I.; Tomás, G.D.; Santos, M.S.; Moreira, P.I.; Socorro, S.; Cavaco, J.E.; Alves, M.G.; Oliveira, P.F., 2014. Biochimica et Biophysica Acta - Bioenergetics. 335 - 344. 3. 1837. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84892411578&partnerID=MN8TOARS . 10.1016/j.bbabio.2013.12.008 . Biochimica et Biophysica Acta - Bioenergetics

Metformin and male reproduction: Effects on Sertoli cell metabolism

Alves, M.G.; Martins, A.D.; Vaz, C.V.; Correia, S.; Moreira, P.I.; Oliveira, P.F.; Socorro, S., 2014. British Journal of Pharmacology. 1033 - 1042. 4. 171. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84893042451&partnerID=MN8TOARS . 10.1111/bph.12522 . British Journal of Pharmacology

Can tea consumption be a safe and effective therapy against diabetes mellitus-induced neurodegeneration?

Nunes, A.R.; Alves, M.G.; Moreira, P.I.; Oliveira, P.F.; Silva, B.M., 2014. Current Neuropharmacology. 475 - 489. 6. 12. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84924963252&partnerID=MN8TOARS . Current Neuropharmacology

Effects of methylglyoxal and pyridoxamine in rat brain mitochondria bioenergetics and oxidative status

Cardoso, S.; Carvalho, C.; Marinho, R.; Simões, A.; Sena, C.M.; Matafome, P.; Santos, M.S.; Seiça, R.M.; Moreira, P.I., 2014. Journal of Bioenergetics and Biomembranes. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901509164&partnerID=MN8TOARS . 10.1007/s10863-014-9551-2 . Journal of Bioenergetics and Biomembranes

The role of endoplasmic reticulum in amyloid precursor protein processing and trafficking: Implications for Alzheimer's disease

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Insulin therapy modulates mitochondrial dynamics and biogenesis, autophagy and tau protein phosphorylation in the brain of type 1 diabetic rats

Santos, R.X.; Correia, S.C.; Alves, M.G.; Oliveira, P.F.; Cardoso, S.; Carvalho, C.; Duarte, A.I.; Santos, M.S.; Moreira, P.I., 2014. Biochimica et Biophysica Acta - Molecular Basis of Disease. 1154 - 1166. 7. 1842. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84899789863&partnerID=MN8TOARS . 10.1016/j.bbadis.2014.04.011 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Enhanced Amyloidogenic Processing of Amyloid Precursor Protein and Cell Death Under Prolonged Endoplasmic Reticulum Stress in Brain Endothelial Cells

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UCP2 and ANT differently modulate proton-leak in brain mitochondria of long-term hyperglycemic and recurrent hypoglycemic rats

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Defective HIF signaling pathway and brain response to hypoxia in neurodegenera-tive diseases: Not an “Iffy” question!

Correia, S.C.; Carvalho, C.; Cardoso, S.; Santos, R.X.; Plácido, A.I.; Candeias, E.; Duarte, A.I.; Moreira, P.I., 2013. Current Pharmaceutical Design. 6809 - 6822. 38. 19. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884829985&partnerID=MN8TOARS . Current Pharmaceutical Design

Insulin-induced recurrent hypoglycemia exacerbates diabetic brain mitochondrial dysfunction and oxidative imbalance

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Hyperglycemia, hypoglycemia and dementia: Role of mitochondria and uncoupling proteins

Cardoso, S.; Correia, S.C.; Santos, R.X.; Carvalho, C.; Candeias, E.; Duarte, A.I.; Plácido, A.I.; Santos, M.S.; Moreira, P.I., 2013. Current Molecular Medicine. 586 - 601. 4. 13. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876735551&partnerID=MN8TOARS . 10.2174/1566524011313040010 . Current Molecular Medicine

Crosstalk between diabetes and brain: Glucagon-like peptide-1 mimetics as a promising therapy against neurodegeneration

Duarte, A.I.; Candeias, E.; Correia, S.C.; Santos, R.X.; Carvalho, C.; Cardoso, S.; Plácido, A.; et al, 2013. Biochimica et Biophysica Acta - Molecular Basis of Disease. 527 - 541. 4. 1832. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873306844&partnerID=MN8TOARS . 10.1016/j.bbadis.2013.01.008 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Neurofilaments are the major neuronal target of hydroxynonenal-mediated protein cross-links

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Mitochondrial DNA oxidative damage and repair in aging and Alzheimer's disease

Santos, R.X.; Correia, S.C.; Zhu, X.; Smith, M.A.; Moreira, P.I.; Castellani, R.J.; Nunomura, A.; Perry, G., 2013. Antioxidants and Redox Signaling. 2444 - 2457. 18. 18. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878619863&partnerID=MN8TOARS . 10.1089/ars.2012.5039 . Antioxidants and Redox Signaling

Mechanism of inhibition of mitochondrial ATP synthase by 17ß-Estradiol

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Hormonal control of Sertoli cell metabolism regulates spermatogenesis

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Type 2 diabetic and alzheimer's disease mice present similar behavioral, cognitive, and vascular anomalies

Carvalho, C.; Machado, N.; Mota, P.C.; Correia, S.C.; Cardoso, S.; Santos, R.X.; Santos, M.S.; Oliveira, C.R.; Moreira, P.I., 2013. Journal of Alzheimer's Disease. 623 - 635. 3. 35. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880196052&partnerID=MN8TOARS . 10.3233/JAD-130005 . Journal of Alzheimer's Disease

Phosphorylation of tau protein as the link between oxidative stress, mitochondrial dysfunction, and connectivity failure: Implications for Alzheimer's disease

Mondragón-Rodríguez, S.; Perry, G.; Zhu, X.; Moreira, P.I.; Acevedo-Aquino, M.C.; Williams, S., 2013. Oxidative Medicine and Cellular Longevity. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880863640&partnerID=MN8TOARS . 10.1155/2013/940603 . Oxidative Medicine and Cellular Longevity

Mitochondrial abnormalities in a streptozotocin-induced rat model of sporadic Alzheimer's disease

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Control of Sertoli cell metabolism by sex steroid hormones is mediated through modulation in glycolysis-related transporters and enzymes

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Mitochondrial-targeted protective properties of isolated diterpenoids from sideritis spp. in response to the deleterious changes induced by H 2O2

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Exposure to 2,4-dichlorophenoxyacetic acid alters glucose metabolism in immature rat Sertoli cells

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High-sugar diets, type 2 diabetes and Alzheimer's disease

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Is exercise-in-a-bottle likely to proffer new insights into Alzheimer's disease?

Correia, S.C.; Perry, G.; Castellani, R.; Moreira, P.I., 2013. Journal of Neurochemistry. 4 - 6. 1. 127. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884846458&partnerID=MN8TOARS . 10.1111/jnc.12406 . Journal of Neurochemistry

Molecular mechanisms beyond glucose transport in diabetes-related male infertility

Alves, M.G.; Martins, A.D.; Rato, L.; Moreira, P.I.; Socorro, S.; Oliveira, P.F., 2013. Biochimica et Biophysica Acta - Molecular Basis of Disease. 626 - 635. 5. 1832. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874414576&partnerID=MN8TOARS . 10.1016/j.bbadis.2013.01.011 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Alzheimer's disease and diabetes: An integrative view of the role of mitochondria, oxidative stress, and insulin

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Metabolic alterations induced by sucrose intake and Alzheimer's disease promote similar brain mitochondrial abnormalities

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Alzheimer disease as a vascular disorder: Where do mitochondria fit?

Correia, S.C.; Santos, R.X.; Cardoso, S.; Carvalho, C.; Candeias, E.; Duarte, A.I.; Plácido, A.I.; Santos, M.S.; Moreira, P.I., 2012. Experimental Gerontology. 878 - 886. 11. 47. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867725518&partnerID=MN8TOARS . 10.1016/j.exger.2012.07.006 . Experimental Gerontology

Androgen-responsive and nonresponsive prostate cancer cells present a distinct glycolytic metabolism profile

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The impairment of insulin signaling in Alzheimer's disease

Candeias, E.; Duarte, A.I.; Carvalho, C.; Correia, S.C.; Cardoso, S.; Santos, R.X.; Plácido, A.I.; Perry, G.; Moreira, P.I., 2012. IUBMB Life. 951 - 957. 12. 64. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870197271&partnerID=MN8TOARS . 10.1002/iub.1098 . IUBMB Life

Mitochondrial importance in Alzheimer's, Huntington's and Parkinson's diseases

Correia, S.C.; Santos, R.X.; Perry, G.; Zhu, X.; Moreira, P.I.; Smith, M.A., 2012. Advances in Experimental Medicine and Biology. 205 - 221. 724. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859514171&partnerID=MN8TOARS . 10.1007/978-1-4614-0653-2_16 . Advances in Experimental Medicine and Biology

Glycogen synthase kinase 3: A point of integration in alzheimer's disease and a therapeutic target?

Mondragón-Rodríguez, S.; Perry, G.; Zhu, X.; Moreira, P.I.; Williams, S., 2012. International Journal of Alzheimer's Disease. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863697825&partnerID=MN8TOARS . 10.1155/2012/276803 . International Journal of Alzheimer's Disease

Oxidative damage to RNA in aging and neurodegenerative disorders

Nunomura, A.; Moreira, P.I.; Castellani, R.J.; Lee, H.-G.; Zhu, X.; Smith, M.A.; Perry, G., 2012. Neurotoxicity Research. 231 - 248. 3. 22. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865407887&partnerID=MN8TOARS . 10.1007/s12640-012-9331-x . Neurotoxicity Research

Impact of diabetes in blood-testis and blood-brain barriers: Resemblances and differences

Alves, M.G.; Oliveira, P.F.; Socorro, S.; Moreira, P.I., 2012. Current Diabetes Reviews. 401 - 412. 6. 8. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870183874&partnerID=MN8TOARS . 10.2174/157339912803529896 . Current Diabetes Reviews

Guidelines for the use and interpretation of assays for monitoring autophagy

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The role of iron as a mediator of oxidative stress in Alzheimer disease

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Insulin signaling, glucose metabolism and mitochondria: Major players in Alzheimer's disease and diabetes interrelation

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Physical exercise as a possible strategy for brain protection: Evidence from mitochondrial-mediated mechanisms

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Cyanide preconditioning protects brain endothelial and NT2 neuron-like cells against glucotoxicity: Role of mitochondrial reactive oxygen species and HIF-1a

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Insulin in central nervous system: More than just a peripheral hormone

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Hydroxynonenal-generated crosslinking fluorophore accumulation in Alzheimer disease reveals a dichotomy of protein turnover

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Nuclear and mitochondrial DNA oxidation in Alzheimer's disease

Santos, R.X.; Correia, S.C.; Zhu, X.; Lee, H.-G.; Petersen, R.B.; Nunomura, A.; Smith, M.A.; Perry, G.; Moreira, P.I., 2012. Free Radical Research. 565 - 576. 4. 46. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863229887&partnerID=MN8TOARS . 10.3109/10715762.2011.648188 . Free Radical Research

SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1a Destabilization

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Neurofilamentopathy in neurodegenerative diseases

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Mitophagy in neurodegeneration: An opportunity for therapy?

Santos, R.X.; Correia, S.C.; Carvalho, C.; Cardoso, S.; Santos, M.S.; Moreira, P.I., 2011. Current Drug Targets. 790 - 799. 6. 12. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955585040&partnerID=MN8TOARS . 10.2174/138945011795528813 . Current Drug Targets

Using biology to untie the Gordian knot of Alzheimer's disease

Perry, G.; Smith, M.A.; Casadesus, G.; Lee, H.-G.; Moreira, P.I.; Castellani, R.J.; Zhu, X., 2011. Journal of Alzheimer's Disease. SUPPL. 1. 23. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952176838&partnerID=MN8TOARS . 10.3233/JAD-2011-001433 . Journal of Alzheimer's Disease

Effects of rapamycin and TOR on aging and memory: Implications for Alzheimer's disease

Santos, R.X.; Correia, S.C.; Cardoso, S.; Carvalho, C.; Santos, M.S.; Moreira, P.I., 2011. Journal of Neurochemistry. 927 - 936. 6. 117. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79957971392&partnerID=MN8TOARS . 10.1111/j.1471-4159.2011.07262.x . Journal of Neurochemistry

Mitochondria as potential targets in antidiabetic therapy

Moreira, P.I.; Oliveira, C.R., 2011. Handbook of Experimental Pharmacology. 331 - 356. 203. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955615960&partnerID=MN8TOARS . 10.1007/978-3-642-17214-4-14 . Handbook of Experimental Pharmacology

Oxidative Stress and Balance in Neurodegenerative Diseases

Collins, G.H.; Mondragón-Rodríguez, S.; Nunomura, A.; Zhu, X.; Moreira, P.I.; Smith, M.A., 2011. Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders: Second Edition. 10 - 12. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886036204&partnerID=MN8TOARS . 10.1002/9781444341256.ch3 . Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders: Second Edition

Mitochondria from distinct tissues are differently affected by 17ß-estradiol and tamoxifen

Moreira, P.I.; Custódio, J.B.A.; Nunes, E.; Oliveira, P.J.; Moreno, A.; Seia, R.; Oliveira, C.R.; Santos, M.S., 2011. Journal of Steroid Biochemistry and Molecular Biology. 8 - 16. 1-2. 123. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650578395&partnerID=MN8TOARS . 10.1016/j.jsbmb.2010.09.004 . Journal of Steroid Biochemistry and Molecular Biology

Impact of STZ-induced hyperglycemia and insulin-induced hypoglycemia in plasma amino acids and cortical synaptosomal neurotransmitters

Cardoso, S.; Carvalho, C.; Santos, R.; Correia, S.; Santos, M.S.; Seiça, R.; Oliveira, C.R.; Moreira, P.I., 2011. Synapse. 457 - 466. 6. 65. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953276927&partnerID=MN8TOARS . 10.1002/syn.20863 . Synapse

Association of mitochondrial signaling in Alzheimer's disease and hypoxia

Carvalho, C.; Correia, S.C.; Santos, R.X.; Cardoso, S.; Moreira, P.I.; Zhu, X.; Smith, M.A.; Perry, G., 2011. Molecular Aspects of Neurodegeneration and Neuroprotection. 50 - 61. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884443449&partnerID=MN8TOARS . 10.2174/978160805092511101010050 . Molecular Aspects of Neurodegeneration and Neuroprotection

New insights into the mechanisms of mitochondrial preconditioning-triggered neuroprotection

Correia, S.C.; Cardoso, S.; Santos, R.X.; Carvalho, C.; Santos, M.S.; Perry, G.; Smith, M.A.; Moreira, P.I., 2011. Current Pharmaceutical Design. 3381 - 3389. 31. 17. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80055089996&partnerID=MN8TOARS . 10.2174/138161211798072490 . Current Pharmaceutical Design

Mitochondrial dysfunction and oxidative stress in Alzheimer's disease

Moreira, P.I., 2010. European Neurological Review. 17 - 21. 1. 5. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-84858166678&partnerID=MN8TOARS . European Neurological Review

Mitochondria: The missing link between preconditioning and neuroprotection

Correia, S.C.; Santos, R.X.; Perry, G.; Zhu, X.; Moreira, P.I.; Smith, M.A., 2010. Journal of Alzheimer's Disease. SUPPL.2. 20. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956220265&partnerID=MN8TOARS . 10.3233/JAD-2010-100669 . Journal of Alzheimer's Disease

Mitochondrial preconditioning: A potential neuroprotective strategy

Correia, S.C.; Carvalho, C.; Cardoso, S.; Santos, R.X.; Santos, M.S.; Oliveira, C.R.; Perry, G.; et al, 2010. Frontiers in Aging Neuroscience. AUG. 2. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955962818&partnerID=MN8TOARS . 10.3389/fnagi.2010.00138 . Frontiers in Aging Neuroscience

Chronic hypoxia potentiates age-related oxidative imbalance in brain vessels and synaptosomes

Carvalho, C.; Santos, M.S.; Baldeiras, I.; Oliveira, C.R.; Seiça, R.; Moreira, P.I., 2010. Current Neurovascular Research. 288 - 300. 4. 7. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650657043&partnerID=MN8TOARS . Current Neurovascular Research

Cortical and hippocampal mitochondria bioenergetics and oxidative status during hyperglycemia and/or insulin-induced hypoglycemia

Cardoso, S.; Santos, M.S.; Seiça, R.; Moreira, P.I., 2010. Biochimica et Biophysica Acta - Molecular Basis of Disease. 942 - 951. 11. 1802. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956710094&partnerID=MN8TOARS . 10.1016/j.bbadis.2010.07.001 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Mitochondria: A therapeutic target in neurodegeneration

Moreira, P.I.; Zhu, X.; Wang, X.; Lee, H.-g.; Nunomura, A.; Petersen, R.B.; Perry, G.; Smith, M.A., 2010. Biochimica et Biophysica Acta - Molecular Basis of Disease. 212 - 220. 1. 1802. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-71849088759&partnerID=MN8TOARS . 10.1016/j.bbadis.2009.10.007 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Targeting autophagy in the brain: A promising approach?

Santos, R.X.; Cardoso, S.; Correia, S.; Carvalho, C.; Santos, M.S.; Moreira, P.I., 2010. Central Nervous System Agents in Medicinal Chemistry. 158 - 168. 2. 10. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953681716&partnerID=MN8TOARS . Central Nervous System Agents in Medicinal Chemistry

Effects of estrogen in the brain: Is it a neuroprotective agent in alzheimer's disease?

Correia, S.C.; Santos, R.X.; Cardoso, S.; Carvalho, C.; Santos, M.S.; Oliveira, C.R.; Moreira, P.I., 2010. Current Aging Science. 113 - 126. 2. 3. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953736213&partnerID=MN8TOARS . 10.2174/1874609811003020113 . Current Aging Science

Alzheimer's Disease: An Overview

Moreira, P.I.; Zhu, X.; Smith, M.A.; Perry, G., 2010. Encyclopedia of Neuroscience. 259 - 263. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-84882903387&partnerID=MN8TOARS . 10.1016/B978-008045046-9.00544-1 . Encyclopedia of Neuroscience

Autophagy in Alzheimers disease

Moreira, P.I.; Santos, R.X.; Zhu, X.; Lee, H.-G.; Smith, M.A.; Casadesus, G.; Perry, G., 2010. Expert Review of Neurotherapeutics. 1209 - 1218. 7. 10. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954196784&partnerID=MN8TOARS . 10.1586/ern.10.84 . Expert Review of Neurotherapeutics

Alzheimer's disease: Diverse aspects of mitochondrial malfunctioning

Santos, R.X.; Correia, S.C.; Wang, X.; Perry, G.; Smith, M.A.; Moreira, P.I.; Zhu, X., 2010. International Journal of Clinical and Experimental Pathology. 570 - 581. 6. 3. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956026971&partnerID=MN8TOARS . International Journal of Clinical and Experimental Pathology

A synergistic dysfunction of mitochondrial fission/fusion dynamics and mitophagy in Alzheimer's disease

Santos, R.X.; Correia, S.C.; Wang, X.; Perry, G.; Smith, M.A.; Moreira, P.I.; Zhu, X., 2010. Journal of Alzheimer's Disease. SUPPL.2. 20. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956199031&partnerID=MN8TOARS . 10.3233/JAD-2010-100666 . Journal of Alzheimer's Disease

Hypoxia-inducible factor 1: A new hope to counteract neurodegeneration?

Correia, S.C.; Moreira, P.I., 2010. Journal of Neurochemistry. 1 - 12. 1. 112. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-71649085107&partnerID=MN8TOARS . 10.1111/j.1471-4159.2009.06443.x . Journal of Neurochemistry

Detection and localization of markers of oxidative stress by in situ methods: application in the study of Alzheimer disease.

Moreira, P.I.; Sayre, L.M.; Zhu, X.; Nunomura, A.; Smith, M.A.; Perry, G., 2010. Methods in molecular biology (Clifton, N.J.). 419 - 434. 610. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77449159407&partnerID=MN8TOARS . Methods in molecular biology (Clifton, N.J.)

Mitochondrial control of autophagic lysosomal pathway in Alzheimer's disease

Cardoso, S.M.; Pereira, C.F.; Moreira, P.I.; Arduino, D.M.; Esteves, A.R.; Oliveira, C.R., 2010. Experimental Neurology. 294 - 298. 2. 223. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952549554&partnerID=MN8TOARS . 10.1016/j.expneurol.2009.06.008 . Experimental Neurology

Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology

Moreira, P.I.; Carvalho, C.; Zhu, X.; Smith, M.A.; Perry, G., 2010. Biochimica et Biophysica Acta - Molecular Basis of Disease. 2 - 10. 1. 1802. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-71749121998&partnerID=MN8TOARS . 10.1016/j.bbadis.2009.10.006 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Role of mitochondrial-mediated signaling pathways in Alzheimer disease and hypoxia

Carvalho, C.; Correia, S.C.; Santos, R.X.; Cardoso, S.; Moreira, P.I.; Clark, T.A.; Zhu, X.; Smith, M.A.; Perry, G., 2009. Journal of Bioenergetics and Biomembranes. 433 - 440. 5. 41. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-70449397210&partnerID=MN8TOARS . 10.1007/s10863-009-9247-1 . Journal of Bioenergetics and Biomembranes

Therapeutic opportunities in Alzheimer disease: Current concepts

Marlatt, M.W.; Moreira, P.I.; Lee, H.-g.; Casadesus, G.; Castellani, R.J.; Takeda, A.; Nunomura, A.; et al, 2009. Frontiers in Medicinal Chemistry. 767 - 788. 1. 4. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880176698&partnerID=MN8TOARS . Frontiers in Medicinal Chemistry

Mitochondria as a therapeutic target in Alzheimer's disease and diabetes

Moreira, P.I.; Cardoso, S.M.; Pereira, C.M.; Santos, M.S.; Oliveira, C.R., 2009. CNS and Neurological Disorders - Drug Targets. 492 - 511. 6. 8. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-75849136180&partnerID=MN8TOARS . 10.2174/187152709789824651 . CNS and Neurological Disorders - Drug Targets

Food deprivation promotes oxidative imbalance in rat brain

Santos, R.X.; Cardoso, S.; Silva, S.; Correia, S.; Carvalho, C.; Crisóstomo, J.; Rodrigues, L.; et al, 2009. Journal of Food Science. 1. 74. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-58649112769&partnerID=MN8TOARS . 10.1111/j.1750-3841.2008.00982.x . Journal of Food Science

Insulin is a two-edged knife on the brain

Cardoso, S.; Correia, S.; Santos, R.X.; Carvalho, C.; Santos, M.S.; Oliveira, C.R.; Perry, G.; et al, 2009. Journal of Alzheimer's Disease. 483 - 507. 3. 18. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-75249106915&partnerID=MN8TOARS . Journal of Alzheimer's Disease

RNA oxidation in Alzheimer disease and related neurodegenerative disorders

Nunomura, A.; Hofer, T.; Moreira, P.I.; Castellani, R.J.; Smith, M.A.; Perry, G., 2009. Acta Neuropathologica. 151 - 166. 1. 118. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-67349251839&partnerID=MN8TOARS . 10.1007/s00401-009-0508-1 . Acta Neuropathologica

Altered redox balance in disease: Can we change the new equilibria?

Perry, G.; Xiongvei, Z.; Moreira, P.I.; Smith, M.A., 2009. Annals of Neurology. 121 - 122. 2. 65. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-62549117802&partnerID=MN8TOARS . 10.1002/ana.21608 . Annals of Neurology

Doxorubicin: The good, the bad and the ugly effect

Carvalho, C.; Santos, R.X.; Cardoso, S.; Correia, S.; Oliveira, P.J.; Santos, M.S.; Moreira, P.I., 2009. Current Medicinal Chemistry. 3267 - 3285. 25. 16. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-70450215499&partnerID=MN8TOARS . 10.2174/092986709788803312 . Current Medicinal Chemistry

Natural oxidant balance in Parkinson disease

Perry, G.; Moreira, P.I.; Siedlak, S.L.; Nunomura, A.; Zhu, X.; Smith, M.A., 2009. Archives of Neurology. 12. 66. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-73549092919&partnerID=MN8TOARS . 10.1001/archneurol.2009.261 . Archives of Neurology

An integrative view of the role of oxidative stress, mitochondria and insulin in Alzheimer's disease

Moreira, P.I.; Duarte, A.I.; Santos, M.S.; Rego, A.C.; Oliveira, C.R., 2009. Journal of Alzheimer's Disease. 741 - 761. 4. 16. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-67649687039&partnerID=MN8TOARS . 10.3233/JAD-2009-0972 . Journal of Alzheimer's Disease

Sublethal RNA oxidation as a mechanism for neurodegenerative disease

Castellani, R.J.; Nunomura, A.; Rolston, R.K.; Moreira, P.I.; Takeda, A.; Perry, G.; Smith, M.A., 2008. International Journal of Molecular Sciences. 789 - 806. 5. 9. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-44649138016&partnerID=MN8TOARS . 10.3390/ijms9050789 . International Journal of Molecular Sciences

Mechanisms of action of metformin in type 2 diabetes and associated complications: an overview.

Correia, S.; Carvalho, C.; Santos, M.S.; Seiça, R.; Oliveira, C.R.; Moreira, P.I., 2008. Mini reviews in medicinal chemistry. 1343 - 1354. 13. 8. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-58149377770&partnerID=MN8TOARS . 10.2174/138955708786369546 . Mini reviews in medicinal chemistry

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

Klionsky, D.J.; Abeliovich, H.; Agostinis, P.; Agrawal, D.K.; Aliev, G.; Askew, D.S.; Baba, M.; et al, 2008. Autophagy. 151 - 175. 2. 4. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-38949108670&partnerID=MN8TOARS . Autophagy

Alzheimer disease and the role of free radicals in the pathogenesis of the disease

Moreira, P.I.; Santos, M.S.; Oliveira, C.R.; Shenk, J.C.; Nunomura, A.; Smith, M.A.; Zhu, X.; Perry, G., 2008. CNS and Neurological Disorders - Drug Targets. 3 - 10. 1. 7. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-42049116923&partnerID=MN8TOARS . 10.2174/187152708783885156 . CNS and Neurological Disorders - Drug Targets

Metformin protects the brain against the oxidative imbalance promoted by type 2 diabetes

Correia, S.; Carvalho, C.; Santos, M.S.; Proença, T.; Nunes, E.; Duarte, A.I.; Monteiro, P.; et al, 2008. Medicinal Chemistry. 358 - 364. 4. 4. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-50049125341&partnerID=MN8TOARS . 10.2174/157340608784872299 . Medicinal Chemistry

Nucleic acid oxidation in Alzheimer disease

Moreira, P.I.; Nunomura, A.; Nakamura, M.; Takeda, A.; Shenk, J.C.; Aliev, G.; Smith, M.A.; Perry, G., 2008. Free Radical Biology and Medicine. 1493 - 1505. 8. 44. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-41149166082&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2008.01.002 . Free Radical Biology and Medicine

Oxidative stress signaling in Alzheimer's disease

Su, B.; Wang, X.; Nunomura, A.; Moreira, P.I.; Lee, H.-G.; Perry, G.; Smith, M.A.; Zhu, X., 2008. Current Alzheimer Research. 525 - 532. 6. 5. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-58049202374&partnerID=MN8TOARS . 10.2174/156720508786898451 . Current Alzheimer Research

Doxorubicin increases the susceptibility of brain mitochondria to Ca2+-induced permeability transition and oxidative damage

Cardoso, S.; Santos, R.X.; Carvalho, C.; Correia, S.; Pereira, G.C.; Pereira, S.S.; Oliveira, P.J.; et al, 2008. Free Radical Biology and Medicine. 1395 - 1402. 10. 45. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-54349099428&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2008.08.008 . Free Radical Biology and Medicine

Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease

Resende, R.; Moreira, P.I.; Proença, T.; Deshpande, A.; Busciglio, J.; Pereira, C.; Oliveira, C.R., 2008. Free Radical Biology and Medicine. 2051 - 2057. 12. 44. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-43849096294&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2008.03.012 . Free Radical Biology and Medicine

Antioxidant therapy in Alzheimer's disease: theory and practice.

Aliev, G.; Obrenovich, M.E.; Reddy, V.P.; Shenk, J.C.; Moreira, P.I.; Nunomura, A.; Zhu, X.; Smith, M.A.; Perry, G., 2008. Mini reviews in medicinal chemistry. 1395 - 1406. 13. 8. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-58149374037&partnerID=MN8TOARS . 10.2174/138955708786369582 . Mini reviews in medicinal chemistry

Metformin promotes isolated rat liver mitochondria impairment

Carvalho, C.; Correia, S.; Santos, M.S.; Seiça, R.; Oliveira, C.R.; Moreira, P.I., 2008. Molecular and Cellular Biochemistry. 75 - 83. 1-2. 308. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-38649115973&partnerID=MN8TOARS . 10.1007/s11010-007-9614-3 . Molecular and Cellular Biochemistry

Amyloid-ß overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

Wang, X.; Su, B.; Siedlak, S.L.; Moreira, P.I.; Fujioka, H.; Wang, Y.; Casadesus, G.; Zhu, X., 2008. Proceedings of the National Academy of Sciences of the United States of America. 19318 - 19323. 49. 105. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-58049218922&partnerID=MN8TOARS . 10.1073/pnas.0804871105 . Proceedings of the National Academy of Sciences of the United States of America

Estradiol affects liver mitochondrial function in ovariectomized and tamoxifen-treated ovariectomized female rats

Moreira, P.I.; Custódio, J.B.A.; Nunes, E.; Moreno, A.; Seiça, R.; Oliveira, C.R.; Santos, M.S., 2007. Toxicology and Applied Pharmacology. 102 - 110. 1. 221. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34247869542&partnerID=MN8TOARS . 10.1016/j.taap.2007.02.006 . Toxicology and Applied Pharmacology

Neuronal death and survival under oxidative stress in Alzheimer and Parkinson diseases

Nunomura, A.; Moreira, P.I.; Lee, H.G.; Zhu, X.; Castellani, R.J.; Smith, M.A.; Perry, G., 2007. CNS and Neurological Disorders - Drug Targets. 411 - 423. 6. 6. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-41749088686&partnerID=MN8TOARS . 10.2174/187152707783399201 . CNS and Neurological Disorders - Drug Targets

Erratum: Increased autophagic degradation of mitochondria in Alzheimer disease (Autophagy)

Moreira, P.I.; Siedlak, S.L.; Wang, X.; Santos, M.S.; Oliveira, C.R.; Tabaton, M.; Nunomura, A.; et al, 2007. Autophagy. 614 - 615. 6. 3. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-35848931249&partnerID=MN8TOARS . Autophagy

Autophagocytosis of mitochondria is prominent in Alzheimer disease

Moreira, P.I.; Siedlak, S.L.; Wang, X.; Santos, M.S.; Oliveira, C.R.; Tabaton, M.; Nunomura, A.; et al, 2007. Journal of Neuropathology and Experimental Neurology. 525 - 532. 6. 66. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34249881080&partnerID=MN8TOARS . 10.1097/01.jnen.0000240476.73532.b0 . Journal of Neuropathology and Experimental Neurology

Lipoic acid and N-acetyl cysteine decrease mitochondrial-related oxidative stress in Alzheimer disease patient fibroblasts

Moreira, P.I.; Harris, P.L.R.; Zhu, X.; Santos, M.S.; Oliveira, C.R.; Smith, M.A.; Perry, G., 2007. Journal of Alzheimer's Disease. 195 - 206. 2. 12. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34848890388&partnerID=MN8TOARS . Journal of Alzheimer's Disease

Oxidative RNA damage and neurodegeneration

Nunomura, A.; Moreira, P.I.; Takeda, A.; Smith, M.A.; Perry, G., 2007. Current Medicinal Chemistry. 2968 - 2975. 28. 14. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-36849076772&partnerID=MN8TOARS . 10.2174/092986707782794078 . Current Medicinal Chemistry

The key role of oxidative stress in alzheimer's disease

Moreira, P.I.; Nunomura, A.; Honda, K.; Aliev, G.; Casadesus, G.; Zhu, X.; Smith, M.A.; Perry, G., 2007. Oxidative Stress and Neurodegenerative Disorders. 267 - 281. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-84882487316&partnerID=MN8TOARS . 10.1016/B978-044452809-4/50153-8 . Oxidative Stress and Neurodegenerative Disorders

Vascular oxidative stress in Alzheimer disease

Zhu, X.; Smith, M.A.; Honda, K.; Aliev, G.; Moreira, P.I.; Nunomura, A.; Casadesus, G.; et al, 2007. Journal of the Neurological Sciences. 240 - 246. 1-2. 257. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34249776958&partnerID=MN8TOARS . 10.1016/j.jns.2007.01.039 . Journal of the Neurological Sciences

Iron: The redox-active center of oxidative stress in Alzheimer disease

Castellani, R.J.; Moreira, P.I.; Liu, G.; Dobson, J.; Perry, G.; Smith, M.A.; Zhu, X., 2007. Neurochemical Research. 1640 - 1645. 10. 32. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548744723&partnerID=MN8TOARS . 10.1007/s11064-007-9360-7 . Neurochemical Research

Prevention and treatment of Alzheimer disease and aging: Antioxidants

Liu, Q.; Xie, F.; Rolston, R.; Moreira, P.I.; Nunomura, A.; Zhu, X.; Smith, M.A.; Perry, G., 2007. Mini-Reviews in Medicinal Chemistry. 171 - 180. 2. 7. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-33847776693&partnerID=MN8TOARS . 10.2174/138955707779802552 . Mini-Reviews in Medicinal Chemistry

Alzheimer's disease: A lesson from mitochondrial dysfunction

Moreira, P.I.; Santos, M.S.; Oliveira, C.R., 2007. Antioxidants and Redox Signaling. 1621 - 1630. 10. 9. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34648831384&partnerID=MN8TOARS . 10.1089/ars.2007.1703 . Antioxidants and Redox Signaling

Indices of metabolic dysfunction and oxidative stress

Casadesus, G.; Moreira, P.I.; Nunomura, A.; Siedlak, S.L.; Bligh-Glover, W.; Balraj, E.; Petot, G.; Smith, M.A.; Perry, G., 2007. Neurochemical Research. 717 - 722. 4-5. 32. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947593456&partnerID=MN8TOARS . 10.1007/s11064-007-9296-y . Neurochemical Research

Erratum: Autophagocytosis of mitochondria is prominent in Alzheimer disease (Journal of Neuropathology and Experimental Neurology (2007) 66, (525-532))

Moreira, P.I.; Siedlak, S.L.; Wang, X.; Santos, M.S.; Oliveira, C.R.; Tabaton, M.; Nunomura, A.; et al, 2007. Journal of Neuropathology and Experimental Neurology. 7. 66. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34447321588&partnerID=MN8TOARS . 10.1097/01.jnen.0000263876.99435.cb . Journal of Neuropathology and Experimental Neurology

Brain mitochondrial dysfunction as a link between Alzheimer's disease and diabetes

Moreira, P.I.; Santos, M.S.; Seiça, R.; Oliveira, C.R., 2007. Journal of the Neurological Sciences. 206 - 214. 1-2. 257. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34249821079&partnerID=MN8TOARS . 10.1016/j.jns.2007.01.017 . Journal of the Neurological Sciences

Neuropathology and treatment of Alzheimer disease: Did we lose the forest for the trees?

Castellani, R.J.; Zhu, X.; Lee, H.-G.; Moreira, P.I.; Perry, G.; Smith, M.A., 2007. Expert Review of Neurotherapeutics. 473 - 485. 5. 7. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34248326079&partnerID=MN8TOARS . 10.1586/14737175.7.5.473 . Expert Review of Neurotherapeutics

Soybean oil treatment impairs glucose-stimulated insulin secretion and changes fatty acid composition of normal and diabetic islets

Nunes, E.; Peixoto, F.; Louro, T.; Sena, C.M.; Santos, M.S.; Matafome, P.; Moreira, P.I.; Seiça, R., 2007. Acta Diabetologica. 121 - 130. 3. 44. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548177719&partnerID=MN8TOARS . 10.1007/s00592-007-0252-8 . Acta Diabetologica

Neuropathology in Alzheimer's disease: awaking from a hundred-year-old dream.

Nunomura, A.; Castellani, R.J.; Lee, H.G.; Moreira, P.I.; Zhu, X.; Perry, G.; Smith, M.A., 2006. Science of aging knowledge environment : SAGE KE. 8. 2006. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33744531637&partnerID=MN8TOARS . 10.1126/sageke.2006.8.pe10 . Science of aging knowledge environment : SAGE KE

Telomeres and telomerase in Alzheimer's disease: Epiphenomena or a new focus for therapeutic strategy?

Franco, S.; Blasco, M.A.; Siedlak, S.L.; Harris, P.L.R.; Moreira, P.I.; Perry, G.; Smith, M.A., 2006. Alzheimer's and Dementia. 164 - 168. 3. 2. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33744931650&partnerID=MN8TOARS . 10.1016/j.jalz.2006.03.001 . Alzheimer's and Dementia

Compensatory responses induced by oxidative stress in Alzheimer disease

Moreira, P.I.; Zhu, X.; Liu, Q.; Honda, K.; Siedlak, S.L.; Harris, P.L.; Smith, M.A.; Perry, G., 2006. Biological Research. 7 - 13. 1. 39. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745840777&partnerID=MN8TOARS . Biological Research

The key role of mitochondria in Alzheimer's disease

Moreira, P.I.; Cardoso, S.M.; Santos, M.S.; Oliveira, C.R., 2006. Journal of Alzheimer's Disease. 101 - 110. 2. 9. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33746066329&partnerID=MN8TOARS . Journal of Alzheimer's Disease

Presenilin mutation: A deadly first hit in Alzheimer disease - A commentary on "aging sensitizes towards ROS formation and lipid peroxidation in PS1M146L transgenic mice"

Zhu, X.; Lee, H.-G.; Moreira, P.I.; Smith, M.A.; Perry, G., 2006. Free Radical Biology and Medicine. 737 - 739. 5. 40. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644659794&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2005.12.028 . Free Radical Biology and Medicine

Foreword: Mitochondria in Alzheimer disease

Moreira, P.I.; Oliveira, C., 2006. Journal of Alzheimer's Disease. 2. 9. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33746065622&partnerID=MN8TOARS . Journal of Alzheimer's Disease

Mitochondrial abnormalities and oxidative imbalance in Alzheimer disease

Zhu, X.; Perry, G.; Moreira, P.I.; Aliev, G.; Cash, A.D.; Hirai, K.; Smith, M.A., 2006. Journal of Alzheimer's Disease. 147 - 153. 2. 9. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33746089859&partnerID=MN8TOARS . Journal of Alzheimer's Disease

Therapeutic options in Alzheimer's disease

Moreira, P.I.; Zhu, X.; Nunomura, A.; Smith, M.A.; Perry, G., 2006. Expert Review of Neurotherapeutics. 897 - 910. 6. 6. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745486884&partnerID=MN8TOARS . 10.1586/14737175.6.6.897 . Expert Review of Neurotherapeutics

Insulin attenuates diabetes-related mitochondrial alterations: A comparative study

Moreira, P.I.; Rolo, A.P.; Sena, C.; Seiça, R.; Oliveira, C.R.; Santos, M.S., 2006. Medicinal Chemistry. 299 - 308. 3. 2. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33746153746&partnerID=MN8TOARS . 10.2174/157340606776930754 . Medicinal Chemistry

The (un)balance between metabolic and oxidative abnormalities and cellular compensatory responses in Alzheimer disease

Moreira, P.I.; Zhu, X.; Lee, H.-G.; Honda, K.; Smith, M.A.; Perry, G., 2006. Mechanisms of Ageing and Development. 501 - 506. 6. 127. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33646160622&partnerID=MN8TOARS . 10.1016/j.mad.2006.01.024 . Mechanisms of Ageing and Development

Tamoxifen and estradiol interact with the flavin mononucleotide site of complex I leading to mitochondrial failure

Moreira, P.I.; Custódio, J.; Moreno, A.; Oliveira, C.R.; Santos, M.S., 2006. Journal of Biological Chemistry. 10143 - 10152. 15. 281. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33744518169&partnerID=MN8TOARS . 10.1074/jbc.M510249200 . Journal of Biological Chemistry

Involvement of oxidative stress in Alzheimer disease

Nunomura, A.; Castellani, R.J.; Zhu, X.; Moreira, P.I.; Perry, G.; Smith, M.A., 2006. Journal of Neuropathology and Experimental Neurology. 631 - 641. 7. 65. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33747861696&partnerID=MN8TOARS . 10.1097/01.jnen.0000228136.58062.bf . Journal of Neuropathology and Experimental Neurology

Brain and brawn: Parallels in oxidative strength

Moreira, P.I.; Honda, K.; Zhu, X.; Nunomura, A.; Casadesus, G.; Smith, M.A.; Perry, G., 2006. Neurology. 2 SUPPL. 1. 66. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644850568&partnerID=MN8TOARS . Neurology

Therapeutic opportunities in Alzheimer Disease: One for all or all for one?

Marlatt, M.W.; Webber, K.M.; Moreira, P.I.; Lee, H.-G.; Casadesus, G.; Honda, K.; Zhu, X.; Perry, G.; Smith, M.A., 2005. Current Medicinal Chemistry. 1137 - 1147. 10. 12. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-18544380930&partnerID=MN8TOARS . 10.2174/0929867053764644 . Current Medicinal Chemistry

Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron

Honda, K.; Smithi, M.A.; Zhu, X.; Baus, D.; Merrick, W.C.; Tartakoff, A.M.; Hattier, T.; et al, 2005. Journal of Biological Chemistry. 20978 - 20986. 22. 280. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-20444383489&partnerID=MN8TOARS . 10.1074/jbc.M500526200 . Journal of Biological Chemistry

Tau phosphorylation in Alzheimer's disease: Pathogen or protector?

Lee, H.-G.; Perry, G.; Moreira, P.I.; Garrett, M.R.; Liu, Q.; Zhu, X.; Takeda, A.; Nunomura, A.; Smith, M.A., 2005. Trends in Molecular Medicine. 164 - 169. 4. 11. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-17044435830&partnerID=MN8TOARS . 10.1016/j.molmed.2005.02.008 . Trends in Molecular Medicine

CoQ10 therapy attenuates amyloid ß-peptide toxicity in brain mitochondria isolated from aged diabetic rats

Moreira, P.I.; Santos, M.S.; Sena, C.; Nunes, E.; Seiça, R.; Oliveira, C.R., 2005. Experimental Neurology. 112 - 119. 1. 196. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-26244447857&partnerID=MN8TOARS . 10.1016/j.expneurol.2005.07.012 . Experimental Neurology

Redox active iron at the center of oxidative stress in Alzheimer disease

Honda, K.; Moreira, P.I.; Liu, Q.; Siedlak, S.L.; Zhu, X.; Smith, M.A.; Perry, G., 2005. Letters in Drug Design and Discovery. 479 - 482. 6. 2. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-24744432930&partnerID=MN8TOARS . 10.2174/1570180054771545 . Letters in Drug Design and Discovery

Mitogen- and stress-activated protein kinase 1: Convergence of the ERK and p38 pathways in Alzheimer's disease

Webber, K.M.; Smith, M.A.; Lee, H.-G.; Harris, P.L.; Moreira, P.; Perry, G.; Zhu, X., 2005. Journal of Neuroscience Research. 554 - 560. 4. 79. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-14144250344&partnerID=MN8TOARS . 10.1002/jnr.20380 . Journal of Neuroscience Research

Alzheimer's disease and oxidative stress: The old problem remains unsolved

Moreira, P.I.; Honda, K.; Liu, Q.; Aliev, G.; Oliveira, C.R.; Santos, M.S.; Zhu, X.; Smith, M.A.; Perry, G., 2005. Current Medicinal Chemistry - Central Nervous System Agents. 51 - 62. 1. 5. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-15344351142&partnerID=MN8TOARS . Current Medicinal Chemistry - Central Nervous System Agents

Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations

Liu, Q.; Smith, M.A.; Avilá, J.; DeBernardis, J.; Kansal, M.; Takeda, A.; Zhu, X.; et al, 2005. Free Radical Biology and Medicine. 746 - 754. 6. 38. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-13844267510&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2004.11.005 . Free Radical Biology and Medicine

A second look into the oxidant mechanisms in Alzheimer's disease

Moreira, P.I.; Oliveira, C.R.; Santos, M.S.; Nunomura, A.; Honda, K.; Zhu, X.; Smith, M.A.; Perry, G., 2005. Current Neurovascular Research. 179 - 184. 2. 2. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-18744402471&partnerID=MN8TOARS . 10.2174/1567202053586758 . Current Neurovascular Research

Redox metals and oxidative abnormalities in human prion diseases

Petersen, R.B.; Siedlak, S.L.; Lee, H.-G.; Kim, Y.-S.; Nunomura, A.; Tagliavini, F.; Ghetti, B.; et al, 2005. Acta Neuropathologica. 232 - 238. 3. 110. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-26444549058&partnerID=MN8TOARS . 10.1007/s00401-005-1034-4 . Acta Neuropathologica

Oxidative damage and Alzheimer's disease: Are antioxidant therapies useful?

Moreira, P.I.; Smith, M.A.; Zhu, X.; Honda, K.; Lee, H.-G.; Aliev, G.; Perry, G., 2005. Drug News and Perspectives. 13 - 19. 1. 18. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-17444377148&partnerID=MN8TOARS . 10.1358/dnp.2005.18.1.877165 . Drug News and Perspectives

Oxidative stress: The old enemy in Alzheimer's disease pathophysiology

Moreira, P.I.; Honda, K.; Liu, Q.; Santos, M.S.; Oliveira, C.R.; Aliev, G.; Nunomura, A.; et al, 2005. Current Alzheimer Research. 403 - 408. 4. 2. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-24644443839&partnerID=MN8TOARS . 10.2174/156720505774330537 . Current Alzheimer Research

Alzheimer's disease-associated neurotoxic mechanisms and neuroprotective strategies

Pereira, C.; Agostinho, P.; Moreira, P.I.; Cardoso, S.M.; Oliveira, C.R., 2005. Current Drug Targets: CNS and Neurological Disorders. 383 - 403. 4. 4. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-23144463734&partnerID=MN8TOARS . 10.2174/1568007054546117 . Current Drug Targets: CNS and Neurological Disorders

Oxidative stress and neurodegeneration

Moreira, P.I.; Smith, M.A.; Zhu, X.; Nunomura, A.; Castellani, R.J.; Perry, G., 2005. Annals of the New York Academy of Sciences. 545 - 552. 1043. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-23744439419&partnerID=MN8TOARS . 10.1196/annals.1333.062 . Annals of the New York Academy of Sciences

Brain mitochondrial injury induced by oxidative stress-related events is prevented by tamoxifen

Moreira, P.I.; Custódio, J.B.; Oliveira, C.R.; Santos, M.S., 2005. Neuropharmacology. 435 - 447. 3. 48. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-13844275276&partnerID=MN8TOARS . 10.1016/j.neuropharm.2004.10.012 . Neuropharmacology

Alzheimer's disease: An intracellular movement disorder?

Zhu, X.; Moreira, P.I.; Smith, M.A.; Perry, G., 2005. Trends in Molecular Medicine. 391 - 393. 9. 11. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-24344483065&partnerID=MN8TOARS . 10.1016/j.molmed.2005.07.002 . Trends in Molecular Medicine

Oxidative stress mechanisms and potential therapeutics in Alzheimer disease

Moreira, P.I.; Siedlak, S.L.; Aliev, G.; Zhu, X.; Cash, A.D.; Smith, M.A.; Perry, G., 2005. Journal of Neural Transmission. 921 - 932. 7. 112. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-20944449836&partnerID=MN8TOARS . 10.1007/s00702-004-0242-8 . Journal of Neural Transmission

Metal ions and oxidative protein modification in neurological disease

Sayre, L.M.; Moreira, P.I.; Smith, M.A.; Perry, G., 2005. Annali dell'Istituto Superiore di Sanita. 143 - 164. 2. 41. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-31644435822&partnerID=MN8TOARS . Annali dell'Istituto Superiore di Sanita

Neurodegenerative pathways in Parkinson's disease: Therapeutic strategies

Cardoso, S.M.; Moreira, P.I.; Agostinho, P.; Pereira, C.; Oliveira, C.R., 2005. Current Drug Targets: CNS and Neurological Disorders. 405 - 419. 4. 4. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-23144431757&partnerID=MN8TOARS . 10.2174/1568007054546072 . Current Drug Targets: CNS and Neurological Disorders

Insulin protects against amyloid ß-peptide toxicity in brain mitochondria of diabetic rats

Moreira, P.I.; Santos, M.S.; Sena, C.; Seiça, R.; Oliveira, C.R., 2005. Neurobiology of Disease. 628 - 637. 3. 18. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-14744294296&partnerID=MN8TOARS . 10.1016/j.nbd.2004.10.017 . Neurobiology of Disease

Chronological primacy of oxidative stress in Alzheimer disease

Smith, M.A.; Nunomura, A.; Lee, H.-G.; Zhu, X.; Moreira, P.I.; Avila, J.; Perry, G., 2005. Neurobiology of Aging. 579 - 580. 5. 26. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-13644249113&partnerID=MN8TOARS . 10.1016/j.neurobiolaging.2004.09.021 . Neurobiology of Aging

Hydroxytamoxifen protects against oxidative stress in brain mitochondria

Moreira, P.I.; Custódio, J.B.; Oliveira, C.R.; Santos, M.S., 2004. Biochemical Pharmacology. 195 - 204. 1. 68. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-2942568021&partnerID=MN8TOARS . 10.1016/j.bcp.2004.03.019 . Biochemical Pharmacology

Therapeutic potential of oxidant mechanisms in Alzheimer's disease

Moreira, P.I.; Smith, M.A.; Zhu, X.; Santos, M.S.; Oliveira, C.R.; Perry, G., 2004. Expert Review of Neurotherapeutics. 995 - 1004. 6. 4. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-8344235899&partnerID=MN8TOARS . 10.1586/14737175.4.6.995 . Expert Review of Neurotherapeutics

Staying connected: Synapses in alzheimer disease

Lee, H.-G.; Moreira, P.I.; Zhu, X.; Smith, M.A.; Perry, G., 2004. American Journal of Pathology. 1461 - 1464. 5. 165. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-7244252913&partnerID=MN8TOARS . American Journal of Pathology

Neurofilament proteins in neurodegenerative diseases

Liu, Q.; Xie, F.; Siedlak, S.L.; Nunomura, A.; Honda, K.; Moreira, P.I.; Zhua, X.; Smith, M.A.; Perry, G., 2004. Cellular and Molecular Life Sciences. 3057 - 3075. 24. 61. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-12144265815&partnerID=MN8TOARS . 10.1007/s00018-004-4268-8 . Cellular and Molecular Life Sciences

Effect of streptozotocin-induced diabetes on rat brain mitochondria

Moreira, P.I.; Santos, M.S.; Moreno, A.M.; Proença, T.; Seiça, R.; de Oliveira, C.R., 2004. Journal of Neuroendocrinology. 32 - 38. 1. 16. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-0742324515&partnerID=MN8TOARS . 10.1111/j.1365-2826.2004.01107.x . Journal of Neuroendocrinology

Neuroprotection strategies: Effect of vinpocetinein in vitro oxidative stress models | Estratégias de neuroprotecção: Efeito da vimpocetina em modelos in vitro de stresse oxidativo

Pereira, C.; Agostinho, P.; Moreira, P.I.; Duarte, A.I.; Santos, M.S.; Oliveira, C.R., 2003. Acta Medica Portuguesa. 401 - 406. 6. 16. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-9644310235&partnerID=MN8TOARS . Acta Medica Portuguesa

Increased vulnerability of brain mitochondria in diabetic (goto-kakizaki) rats with aging and amyloid-ß exposure

Moreira, P.I.; Santos, M.S.; Moreno, A.M.; Seiça, R.; Oliveira, C.R., 2003. Diabetes. 1449 - 1456. 6. 52. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038321341&partnerID=MN8TOARS . 10.2337/diabetes.52.6.1449 . Diabetes

Effect of amyloid ß-peptide on permeability transition pore: A comparative study

Moreira, P.I.; Santos, M.S.; Moreno, A.; Rego, A.C.; Oliveira, C., 2002. Journal of Neuroscience Research. 257 - 267. 2. 69. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037100213&partnerID=MN8TOARS . 10.1002/jnr.10282 . Journal of Neuroscience Research

Amyloid ß-peptide promotes permeability transition pore in brain mitochondria

Moreira, P.I.; Santos, M.S.; Moreno, A.; Oliveira, C., 2001. Bioscience Reports. 789 - 800. 6. 21. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035780141&partnerID=MN8TOARS . 10.1023/A:1015536808304 . Bioscience Reports

Synaptosomal response to oxidative stress: Effect of vinpocetine

Santos, M.S.; Duarte, A.I.; Moreira, P.I.; Oliveira, C.R., 2000. Free Radical Research. 57 - 66. 1. 32. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033988559&partnerID=MN8TOARS . Free Radical Research

Effect of zinc ions on the cytotoxicity induced by the amyloid ß- peptide

Moreira, P.; Pereira, C.; Santos, M.S.; Oliveira, C., 2000. Antioxidants and Redox Signaling. 317 - 325. 2. 2. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033949740&partnerID=MN8TOARS . Antioxidants and Redox Signaling

Susceptibility to ß-amyloid-induced toxicity is decreased in Goto- Kakizaki diabetic rats: Involvement of oxidative stress

Pereira, C.; Moreira, P.; Seiça, R.; Santos, M.S.; Oliveira, C.R., 2000. Experimental Neurology. 383 - 391. 1. 161. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034051172&partnerID=MN8TOARS . 10.1006/exnr.1999.7270 . Experimental Neurology

Awards

2003

Stimulus to Research Prize, Calouste Gulbenkian Foundation (PMoreira);

2003

Best Poster Presentation Prize; Physiological Society Spring workshop, The Physiological Society (PMoreira);

2008

L’Oreal for Women in Science, L’Oreal Portugal, UNESCO and Fundação para a Ciência e a Tecnologia (PMoreira);

2010

ASN Neuro Poster Prize, The American Society of Neurochemistry (SCorreia);

2013

“Best Scientific Paper in Basic Science” Prize, Faculty of Medicine, University of Coimbra (SCardoso)

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