Alzheimer disease
Diabetes
Mitochondria
Redox status
Pharmacological and non-pharmacological strategies
Exploring the mitochondrial mechanisms underlying type 2 diabetes-associated brain damage
Clarifying the role of oxygen sensing and signaling in the pathophysiology of Alzheimer disease (AD)
Elucidating the role of sexual dimorphism in the predisposition to AD
Evaluating the benefits of mitochondrial modulators in AD
Our research group aims to elucidate the role of mitochondria-linked mechanisms, hypoxic stress signaling and sex dimorphism in brain changes associated to diabetes and age-related neurodegenerative diseases, particularly Alzheimer disease. We are also interested in studying the preventive and/or therapeutic potential of some pharmacological and non-pharmacological strategies. To achieve our goals, we use several experimental models such as human brain and peripheral blood samples and in vitro and in vivo/ex vivo models of the above-mentioned diseases. In our studies we mainly use biochemistry and cell and molecular biology methods and techniques.
Information about journal articles, updated at 03-11-2024, from platform CIÊNCIAVITAE.
Protective effects of 2,4-dinitrophenol in okadaic acid-induced cellular model of Alzheimer's disease
Cardoso, Susana; Carvalho, Cristina; Correia, Sónia C.; Moreira, Paula I., 2024. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 6. 1870. 2024. http://dx.doi.org/10.1016/j.bbadis.2024.167222 . 10.1016/j.bbadis.2024.167222 . Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
MitoTempo protects against ne-carboxymethyl lysine-induced mitochondrial dyshomeostasis and neuronal cells injury
Carvalho, Cristina; Moreira, Paula I., 2024. Free Radical Biology and Medicine. 192 - 206. 220. 2024. http://dx.doi.org/10.1016/j.freeradbiomed.2024.05.011 . 10.1016/j.freeradbiomed.2024.05.011 . Free Radical Biology and Medicine
Fueling Alzheimer’s Disease: Where Does Immunometabolism Stand?
Correia, Sónia C.; Perry, George; Moreira, Paula I., 2024. Journal of Alzheimer's Disease. S363 - S385. s1. 100. 2024. http://dx.doi.org/10.3233/jad-240787 . 10.3233/jad-240787 . Journal of Alzheimer's Disease
Mapping the lipidome in mitochondria-associated membranes (MAMs) in an in vitro model of Alzheimer's disease
Fernandes, Tânia; Melo, Tânia; Conde, Tiago; Neves, Bruna; Domingues, Pedro; Resende, Rosa; Pereira, Cláudia F.; Moreira, Paula I.; Domingues, Maria Rosário, 2024. Journal of Neurochemistry. 2024. http://dx.doi.org/10.1111/jnc.16072 . 10.1111/jnc.16072 . Journal of Neurochemistry
A Perspective on the Link between Mitochondria-Associated Membranes (MAMs) and Lipid Droplets Metabolism in Neurodegenerative Diseases
Tânia Fernandes; M. Rosário Domingues; Paula I. Moreira; Cláudia F. Pereira, 2023. Biology. 2023. https://doi.org/10.3390/biology12030414 . 10.3390/biology12030414 . Biology
Current Advances in Mitochondrial Targeted Interventions in Alzheimer's Disease
Tiago Sousa; Paula I. Moreira; Susana Cardoso, 2023. Biomedicines. 2023. https://doi.org/10.3390/biomedicines11092331 . 10.3390/biomedicines11092331 . Biomedicines
Therapeutic potential of glutaminyl cyclases: Current status and emerging trends
Coimbra, Judite R.M.; Moreira, Paula I.; Santos, Armanda E.; Salvador, Jorge A.R., 2023. Drug Discovery Today. 2023. http://dx.doi.org/10.1016/j.drudis.2023.103644 . 10.1016/j.drudis.2023.103644 . Drug Discovery Today
Retinal imaging in animal models: Searching for biomarkers of neurodegeneration
Batista, Ana; Guimarães, Pedro; Serranho, Pedro; Nunes, Ana; Martins, João; Moreira, Paula I.; Ambrósio, António Francisco; et al, 2023. Frontiers in Ophthalmology. 3. 2023. http://dx.doi.org/10.3389/fopht.2023.1156605 . 10.3389/fopht.2023.1156605 . Frontiers in Ophthalmology
Redox signalling and proteostasis in neurodegeneration: In vivo effects of the mitochondria-targeted antioxidant MitoQ in Huntington's disease mice
Pinho, Brígida R.; Duarte, Ana I.; Canas, Paula M.; Moreira, Paula I.; Murphy, Michael P.; Oliveira, Jorge M.A., 2023. Free Radical Biology and Medicine. S5 - S6. 198. 2023. http://dx.doi.org/10.1016/j.freeradbiomed.2022.12.030 . 10.1016/j.freeradbiomed.2022.12.030 . Free Radical Biology and Medicine
Normative mice retinal thickness: 16-month longitudinal characterization of wild-type mice and changes in a model of Alzheimer's disease
Batista, Ana; Guimarães, Pedro; Martins, João; Moreira, Paula I.; Ambrósio, António Francisco; Castelo-Branco, Miguel; Serranho, Pedro; Bernardes, Rui, 2023. Frontiers in Aging Neuroscience. 15. 2023. http://dx.doi.org/10.3389/fnagi.2023.1161847 . 10.3389/fnagi.2023.1161847 . Frontiers in Aging Neuroscience
Metabolic defects shared by Alzheimer's disease and diabetes: A focus on mitochondria
Cristina Carvalho; Paula I. Moreira, 2023. Current Opinion in Neurobiology. 2023. https://doi.org/10.1016/j.conb.2023.102694 . 10.1016/j.conb.2023.102694 . Current Opinion in Neurobiology
WWOX inhibition by Zfra1-31 restores mitochondrial homeostasis and viability of neuronal cells exposed to high glucose
Cristina Carvalho; Sónia C. Correia; Raquel Seiça; Paula I. Moreira, 2022. Cellular and Molecular Life Sciences. 2022. https://doi.org/10.1007/s00018-022-04508-7 . 10.1007/s00018-022-04508-7 . Cellular and Molecular Life Sciences
ER-mitochondria communication is involved in NLRP3 inflammasome activation under stress conditions in the innate immune system
Pereira, Ana Catarina; De Pascale, Jessica; Resende, Rosa; Cardoso, Susana; Ferreira, Isabel; Neves, Bruno Miguel; Carrascal, Mylène A.; et al, 2022. Cellular and Molecular Life Sciences. 4. 79. 2022. http://dx.doi.org/10.1007/s00018-022-04211-7 . 10.1007/s00018-022-04211-7 . Cellular and Molecular Life Sciences
Hypoxic preconditioning averts sporadic Alzheimer’s disease-like phenotype in rats: a focus on mitochondria
Correia, Sónia C.; Alves, Marco G.; Oliveira, Pedro F.; Casadesus, Gemma; LaManna, Joseph; Perry, George; Moreira, Paula I., 2022. Antioxidants & Redox Signaling. 2022. http://dx.doi.org/10.1089/ars.2019.8007 . 10.1089/ars.2019.8007 . Antioxidants & Redox Signaling
Retinal Aging in 3× Tg-AD Mice Model of Alzheimer's Disease
Guimarães, Pedro; Serranho, Pedro; Martins, João; Moreira, Paula I.; Ambrósio, António Francisco; Castelo-Branco, Miguel; Bernardes, Rui, 2022. Frontiers in Aging Neuroscience. 14. 2022. http://dx.doi.org/10.3389/fnagi.2022.832195 . 10.3389/fnagi.2022.832195 . Frontiers in Aging Neuroscience
Longitudinal OCT texture analysis to assess the retinal changes in the triple-transgenic mouse model of Alzheimer's disease
Bernardes, Rui; Ghalati, Maryam; Ferreira, Hugo; Martins, João; Guimarães, Pedro; Moreira, Paula; Ambrósio, António; Castelo-Branco, Miguel; Serranho, Pedro, 2022. Acta Ophthalmologica. S275. 100. 2022. http://dx.doi.org/10.1111/j.1755-3768.2022.0173 . 10.1111/j.1755-3768.2022.0173 . Acta Ophthalmologica
Stage-independent biomarkers for Alzheimer’s disease from the living retina: an animal study
Ferreira, Hugo; Serranho, Pedro; Guimarães, Pedro; Trindade, Rita; Martins, João; Moreira, Paula I.; Ambrósio, António Francisco; Castelo-Branco, Miguel; Bernardes, Rui, 2022. Scientific Reports. 1. 12. 2022. http://dx.doi.org/10.1038/s41598-022-18113-y . 10.1038/s41598-022-18113-y . Scientific Reports
Type 2 Diabetes Induces a Pro-Oxidative Environment in Rat Epididymis by Disrupting SIRT1/PGC-1a/SIRT3 Pathway
Antónia Diniz; Marco G. Alves; Emanuel Candeias; Ana I. Duarte; Paula I. Moreira; Branca M. Silva; Pedro F. Oliveira; Luís Rato, 2022. International Journal of Molecular Sciences. 2022. https://doi.org/10.3390/ijms23168912 . 10.3390/ijms23168912 . International Journal of Molecular Sciences
WWOX: A New Therapeutic Target In Type 2 Diabetes-Associated Neurodegeneration
Carvalho, Cristina; Moreira, Paula I., 2021. Metabolism. 116. 2021. http://dx.doi.org/10.1016/j.metabol.2020.154616 . 10.1016/j.metabol.2020.154616 . Metabolism
IGF1R Deficiency Modulates Brain Signaling Pathways and Disturbs Mitochondria and Redox Homeostasis
Susana Cardoso; Icíar López; Sergio Piñeiro-Hermida; José Pichel; Paula Moreira, 2021. Biomedicines. 158 - 158. 2. 9. 2021. https://doi.org/10.3390/biomedicines9020158 . 10.3390/biomedicines9020158 . Biomedicines
Oxygen Sensing and Signaling in Alzheimer's Disease: A Breathtaking Story!
Sónia C. Correia; Paula I. Moreira, 2021. Cellular and Molecular Neurobiology. 2021. https://doi.org/10.1007/s10571-021-01148-6 . 10.1007/s10571-021-01148-6 . Cellular and Molecular Neurobiology
Intermittent Hypoxic Conditioning Rescues Cognition and Mitochondrial Bioenergetic Profile in the Triple Transgenic Mouse Model of Alzheimer's Disease
Sónia C. Correia; Nuno J. Machado; Marco G. Alves; Pedro F. Oliveira; Paula I. Moreira, 2021. International Journal of Molecular Sciences. 461 - 461. 1. 22. 2021. https://doi.org/10.3390/ijms22010461 . 10.3390/ijms22010461 . International Journal of Molecular Sciences
Structural and Functional Alterations in Mitochondria-Associated Membranes (MAMs) and in Mitochondria Activate Stress Response Mechanisms in an In Vitro Model of Alzheimer's Disease
Tânia Fernandes; Rosa Resende; Diana F. Silva; Ana P. Marques; Armanda E. Santos; Sandra M. Cardoso; M. Rosário Domingues; Paula I. Moreira; Cláudia F. Pereira, 2021. Biomedicines. 881 - 881. 8. 9. 2021. https://doi.org/10.3390/biomedicines9080881 . 10.3390/biomedicines9080881 . Biomedicines
Longitudinal normative OCT retinal thickness data for wild-type mice, and characterization of changes in the 3×Tg-AD mice model of Alzheimer's disease
Ferreira, Hugo; Martins, João; Moreira, Paula I.; Ambrósio, António Francisco; Castelo-Branco, Miguel; Serranho, Pedro; Bernardes, Rui, 2021. Aging. 2021. http://dx.doi.org/10.18632/aging.202916 . 10.18632/aging.202916 . Aging
Insulin-Induced Recurrent Hypoglycemia Up-Regulates Glucose Metabolism in the Brain Cortex of Chemically Induced Diabetic Rats
Susana Cardoso; Paula I. Moreira, 2021. International Journal of Molecular Sciences. 2021. https://doi.org/10.3390/ijms222413470 . 10.3390/ijms222413470 . International Journal of Molecular Sciences
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
Klionsky, Daniel J.; Abdel-Aziz, Amal Kamal; Abdelfatah, Sara; Abdellatif, Mahmoud; Abdoli, Asghar; Abel, Steffen; Abeliovich, Hagai; et al, 2021. Autophagy. 1 - 382. 1. 17. 2021. http://dx.doi.org/10.1080/15548627.2020.1797280 . 10.1080/15548627.2020.1797280 . Autophagy
The interplay between redox signalling and proteostasis in neurodegeneration: In vivo effects of a mitochondria-targeted antioxidant in Huntington's disease mice
Pinho, Brígida R.; Duarte, Ana I.; Canas, Paula M.; Moreira, Paula I.; Murphy, Michael P.; Oliveira, Jorge M.A., 2020. Free Radical Biology and Medicine. 372 - 382. 146. 2020. http://dx.doi.org/10.1016/j.freeradbiomed.2019.11.021 . 10.1016/j.freeradbiomed.2019.11.021 . Free Radical Biology and Medicine
Liraglutide Protects Against Brain Amyloid-ß1-42 Accumulation in Female Mice with Early Alzheimer's Disease-Like Pathology by Partially Rescuing Oxidative/Nitrosative Stress and Inflammation
Ana I. Duarte; Emanuel Candeias; Inês N. Alves; Débora Mena; Daniela F. Silva; Nuno J. Machado; Elisa J. Campos; et al, 2020. International Journal of Molecular Sciences. 2020. https://doi.org/10.3390/ijms21051746 . 10.3390/ijms21051746 . International Journal of Molecular Sciences
Associations between Trace Elements and Cognitive Decline: An Exploratory 5-Year Follow-Up Study of an Elderly Cohort
Bianca Gerardo; Marina Cabral Pinto; Joana Nogueira; Paula Pinto; Agostinho Almeida; Edgar Pinto; Paula Marinho-Reis; et al, 2020. International Journal of Environmental Research and Public Health. 2020. https://doi.org/10.3390/ijerph17176051 . 10.3390/ijerph17176051 . International Journal of Environmental Research and Public Health
Combining Virtual Screening Protocol and In Vitro Evaluation towards the Discovery of BACE1 Inhibitors
Coimbra, Judite R. M.; Baptista, Salete J.; Dinis, Teresa C. P.; Silva, Maria M. C.; Moreira, Paula I.; Santos, Armanda E.; Salvador, Jorge A. R., 2020. Biomolecules. 4. 10. 2020. http://dx.doi.org/10.3390/biom10040535 . 10.3390/biom10040535 . Biomolecules
Characterization of the retinal changes of the 3×Tg-AD mouse model of Alzheimer's disease
Ferreira, Hugo; Martins, João; Nunes, Ana; Moreira, Paula I.; Castelo-Branco, Miguel; Ambrósio, António Francisco; Serranho, Pedro; Bernardes, Rui, 2020. Health and Technology. 1816 - 1821. 2020. http://dx.doi.org/10.1007/s12553-020-00413-w . 10.1007/s12553-020-00413-w . Health and Technology
Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing
Cunnane, Stephen C.; Trushina, Eugenia; Morland, Cecilie; Prigione, Alessandro; Casadesus, Gemma; Andrews, Zane B.; Beal, M. Flint; et al, 2020. Nature Reviews Drug Discovery. 2020. http://dx.doi.org/10.1038/s41573-020-0072-x . 10.1038/s41573-020-0072-x . Nature Reviews Drug Discovery
Characterization of the retina of the triple-transgenic mice model of Alzheimer's disease: onset and progression of the disease
Bernardes, Rui; Ferreira, Hugo; Martins, Joao; Moreira, Paula; Francisco Ambrosio, Antonio; Castelo-Branco, Miguel; Serranho, Pedro, 2020. Neurology. 2020. https://publons.com/wos-op/publon/40788837/ . Neurology
PINK1/PARKIN signalling in neurodegeneration and neuroinflammation
Quinn, Peter M. J.; Moreira, Paula I.; Ambrósio, António Francisco; Alves, C. Henrique, 2020. Acta Neuropathologica Communications. 1. 8. 2020. http://dx.doi.org/10.1186/s40478-020-01062-w . 10.1186/s40478-020-01062-w . published Acta Neuropathologica Communications
Mitochondria, endoplasmic reticulum and innate immune dysfunction in mood disorders: Do Mitochondria-Associated Membranes (MAMs) play a role?
Resende, R.; Fernandes, T.; Pereira, A.C.; De Pascale, J.; Marques, A.P.; Oliveira, P.; Morais, S.; et al, 2020. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 6. 1866. 2020. http://dx.doi.org/10.1016/j.bbadis.2020.165752 . 10.1016/j.bbadis.2020.165752 . Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Texture biomarkers of Alzheimer's disease: human vs. mouse model of disease
Nunes, Ana; Ambrósio, António Francisco; Santana, Isabel; Santiago, Beatriz; Moreira, Paula; Castelo-Branco, Miguel; Bernardes, Rui, 2020. Alzheimer's Research & Therapy. 2020. submitted Alzheimer's Research & Therapy
Tortuous Paths of Insulin Signaling and Mitochondria in Alzheimer's Disease.
Moreira, PI, 2019. Advances in experimental medicine and biology. 2019. https://doi.org/10.1007/978-981-13-3540-2_9 . 10.1007/978-981-13-3540-2_9 . Advances in experimental medicine and biology
Diabesity and brain disturbances: A metabolic perspective
Susana Cardoso; Paula I. Moreira, 2019. Molecular Aspects of Medicine. 71 - 79. 66. 2019. https://doi.org/10.1016/j.mam.2018.10.002 . 10.1016/j.mam.2018.10.002 . Molecular Aspects of Medicine
The Retina as a Window or Mirror of the Brain Changes Detected in Alzheimer's Disease: Critical Aspects to Unravel
Chiquita, Samuel; Rodrigues-Neves, Ana C.; Baptista, Filipa I.; Carecho, Rafael; Moreira, Paula I.; Castelo-Branco, Miguel; Ambrósio, António F., 2019. Molecular Neurobiology. 5416 - 5435. 8. 56. 2019. http://dx.doi.org/10.1007/s12035-018-1461-6 . 10.1007/s12035-018-1461-6 . Molecular Neurobiology
Retinal thinning of inner sub-layers is associated with cortical atrophy in a mouse model of Alzheimer's disease: a longitudinal multimodal in vivo study
Chiquita, Samuel; Campos, Elisa J.; Castelhano, João; Ribeiro, Mário; Sereno, José; Moreira, Paula I.; Castelo-Branco, Miguel; Ambrósio, António Francisco, 2019. Alzheimer's Research & Therapy. 1. 11. 2019. http://dx.doi.org/10.1186/s13195-019-0542-8 . 10.1186/s13195-019-0542-8 . Alzheimer's Research & Therapy
A longitudinal multimodal in vivo molecular imaging study of the 3xTg-AD mouse model shows progressive early hippocampal and taurine loss
Chiquita, Samuel; Ribeiro, Mário; Castelhano, João; Oliveira, Francisco; Sereno, José; Batista, Marta; Abrunhosa, Antero; et al, 2019. Human Molecular Genetics. 2174 - 2188. 13. 28. 2019. http://dx.doi.org/10.1093/hmg/ddz045 . 10.1093/hmg/ddz045 . Human Molecular Genetics
Diminished O-GlcNAcylation in Alzheimer's disease is strongly correlated with mitochondrial anomalies
Pinho, Tiffany S.; Correia, Sónia C.; Perry, George; Ambrósio, António Francisco; Moreira, Paula I., 2019. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2048 - 2059. 8. 1865. 2019. http://dx.doi.org/10.1016/j.bbadis.2018.10.037 . 10.1016/j.bbadis.2018.10.037 . Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Retinal thickness of the triple-transgenic mice model of Alzheimer's disease at the age of one month
Bernardes, Rui; Ferreira, Hugo; Martins, João; Moreira, Paula I.; Castelo-Branco, Miguel; Ambrósio, António F.; Serranho, Pedro, 2019. Acta Ophthalmologica. S263. 97. 2019. http://dx.doi.org/10.1111/j.1755-3768.2019.5467 . 10.1111/j.1755-3768.2019.5467 . Acta Ophthalmologica
Can the retina show similar molecular and cellular changes as the brain in an animal model of Alzheimer's disease?
Rodrigues-Neves, Ana Catarina; Carecho, Rafael; Baptista, Filipa; Moreira, Paula; Ambrósio, António, 2019. Frontiers in Cellular Neuroscience. 13. 2019. http://dx.doi.org/10.3389/conf.fncel.2019.01.00020 . 10.3389/conf.fncel.2019.01.00020 . Frontiers in Cellular Neuroscience
Is Alzheimer's disease an inflammasomopathy?
Pereira, Claudia F.; Santos, Armanda E.; Moreira, Paula I.; Pereira, Ana Catarina; Sousa, Fabio J.; Cardoso, Sandra M.; Cruz, M. Teresa, 2019. Ageing Research Reviews. 56. 2019. http://dx.doi.org/10.1016/j.arr.2019.100966 . 10.1016/j.arr.2019.100966 . Ageing Research Reviews
Links between Cognitive Status and Trace Element Levels in Hair for an Environmentally Exposed Population: A Case Study in the Surroundings of the Estarreja Industrial Area
Cabral Pinto, Marina M. S.; Marinho-Reis, Paula; Almeida, Agostinho; Pinto, Edgar; Neves, Orquídia; Inácio, Manuela; Gerardo, Bianca; et al, 2019. International Journal of Environmental Research and Public Health. 22. 16. 2019. http://dx.doi.org/10.3390/ijerph16224560 . 10.3390/ijerph16224560 . International Journal of Environmental Research and Public Health
An overview of glutaminyl cyclase inhibitors for Alzheimer’s disease
Coimbra, Judite RM; Sobral, Pedro JM; Santos, Armanda E; Moreira, Paula I; Salvador, Jorge AR, 2019. Future Medicinal Chemistry. 3179 - 3194. 24. 11. 2019. http://dx.doi.org/10.4155/fmc-2019-0163 . 10.4155/fmc-2019-0163 . Future Medicinal Chemistry
Post-translational modifications in brain health and disease
Correia, Sónia C.; Carvalho, Cristina; Cardoso, Susana; Moreira, Paula I., 2019. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1947 - 1948. 8. 1865. 2019. http://dx.doi.org/10.1016/j.bbadis.2019.05.006 . 10.1016/j.bbadis.2019.05.006 . Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Sweet Mitochondria: A Shortcut to Alzheimer's Disease
Moreira, P.I., 2018. Journal of Alzheimer's Disease. 1391 - 1401. 3. 62. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85044360897&partnerID=MN8TOARS . 10.3233/JAD-170931 . Journal of Alzheimer's Disease
The beneficial role of exercise in mitigating doxorubicin-induced Mitochondrionopathy
Marques-Aleixo, I.; Santos-Alves, E.; Oliveira, P.J.; Moreira, P.I.; Magalhães, J.; Ascensão, A., 2018. Biochimica et Biophysica Acta - Reviews on Cancer. 189 - 199. 2. 1869. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85041805508&partnerID=MN8TOARS . 10.1016/j.bbcan.2018.01.002 . Biochimica et Biophysica Acta - Reviews on Cancer
Brain insulin signalling, glucose metabolism and females' reproductive aging: A dangerous triad in Alzheimer's disease
Duarte, A.I.; Santos, M.S.; Oliveira, C.R.; Moreira, P.I., 2018. Neuropharmacology. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85044268663&partnerID=MN8TOARS . 10.1016/j.neuropharm.2018.01.044 . Neuropharmacology
Dual Therapy with Liraglutide and Ghrelin Promotes Brain and Peripheral Energy Metabolism in the R6/2 Mouse Model of Huntington's Disease
Ana I. Duarte; Marie Sjögren; Maria S. Santos; Catarina R. Oliveira; Paula I. Moreira; Maria Björkqvist, 2018. Scientific Reports. 1. 8. 2018. https://doi.org/10.1038/s41598-018-27121-w . 10.1038/s41598-018-27121-w . Scientific Reports
Fingernail Trace Element Content in Environmentally Exposed Individuals and Its Influence on Their Cognitive Status in Ageing
Cabral Pinto, Marina M. S.; Marinho-Reis, A. Paula; Almeida, Agostinho; Freitas, Sandra; Simões, Mário R.; Diniz, M. Luísa; Pinto, Edgar; et al, 2018. Exposure and Health. 181 - 194. 3. 11. 2018. http://dx.doi.org/10.1007/s12403-018-0274-1 . 10.1007/s12403-018-0274-1 . Exposure and Health
O-GlcNAcylation and neuronal energy status: Implications for Alzheimer's disease
Tiffany S. Pinho; Diogo M. Verde; Sónia C. Correia; Susana M. Cardoso; Paula I. Moreira, 2018. Ageing Research Reviews. 32 - 41. 46. 2018. https://doi.org/10.1016/j.arr.2018.05.003 . 10.1016/j.arr.2018.05.003 . Ageing Research Reviews
Beneficial effects of white wine polyphenols-enriched diet on Alzheimer's disease-like pathology
Mendes, D.; Oliveira, M.M.; Moreira, P.I.; Coutinho, J.; Nunes, F.M.; Pereira, D.M.; Valentão, P.; Andrade, P.B.; Videira, R.A., 2018. Journal of Nutritional Biochemistry. 165 - 177. 55. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85043298266&partnerID=MN8TOARS . 10.1016/j.jnutbio.2018.02.001 . Journal of Nutritional Biochemistry
Selenoprotein S Reduces Endoplasmic Reticulum Stress-Induced Phosphorylation of Tau: Potential Role in Selenate Mitigation of Tau Pathology
Rueli, R.H.L.H.; Torres, D.J.; Dewing, A.S.T.; Kiyohara, A.C.; Barayuga, S.M.; Bellinger, M.T.; Uyehara-Lock, J.H.; et al, 2017. Journal of Alzheimer's Disease. 749 - 762. 2. 55. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-84999116043&partnerID=MN8TOARS . 10.3233/JAD-151208 . Journal of Alzheimer's Disease
Mitochondria as a target for neuroprotection: implications for Alzheimer´s disease
Cardoso, S.; Seiça, R.M.; Moreira, P.I., 2017. Expert Review of Neurotherapeutics. 77 - 91. 1. 17. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85003782022&partnerID=MN8TOARS . 10.1080/14737175.2016.1205488 . Expert Review of Neurotherapeutics
Uncoupling Protein 2 Inhibition Exacerbates Glucose Fluctuation-Mediated Neuronal Effects
Cardoso, S.; Seiça, R.M.; Moreira, P.I., 2017. Neurotoxicity Research. 1 - 14. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85028984223&partnerID=MN8TOARS . 10.1007/s12640-017-9805-y . Neurotoxicity Research
Phosphatase 2A Inhibition Affects Endoplasmic Reticulum and Mitochondria Homeostasis Via Cytoskeletal Alterations in Brain Endothelial Cells
Ana I. Plácido; Cláudia M. F. Pereira; Sónia C. Correira; Cristina Carvalho; Catarina R. Oliveira; Paula I. Moreira, 2017. Molecular Neurobiology. 2017. http://dx.doi.org/10.1007/s12035-015-9640-1 . 10.1007/s12035-015-9640-1 . Molecular Neurobiology
Brain GLP-1/IGF-1 Signaling and Autophagy Mediate Exendin-4 Protection Against Apoptosis in Type 2 Diabetic Rats
Candeias, Emanuel; Sebastião, Inês; Cardoso, Susana; Carvalho, Cristina; Santos, Maria Sancha; Oliveira, Catarina Resende; Moreira, Paula I.; Duarte, Ana I., 2017. Molecular Neurobiology. 2017. http://dx.doi.org/10.1007/s12035-017-0622-3 . 10.1007/s12035-017-0622-3 . Molecular Neurobiology
Human predisposition to cognitive impairment and its relation with environmental exposure to potentially toxic elements
Cabral Pinto, M.M.S.; Marinho-Reis, A.P.; Almeida, A.; Ordens, C.M.; Silva, M.M.V.G.; Freitas, S.; Simões, M.R.; et al, 2017. Environmental Geochemistry and Health. 1 - 18. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85014615707&partnerID=MN8TOARS . 10.1007/s10653-017-9928-3 . Environmental Geochemistry and Health
Insights into the human brain proteome: Disclosing the biological meaning of protein networks in cerebrospinal fluid
Bastos, P.; Ferreira, R.; Manadas, B.; Moreira, P.I.; Vitorino, R., 2017. Critical Reviews in Clinical Laboratory Sciences. 185 - 204. 3. 54. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85019117156&partnerID=MN8TOARS . 10.1080/10408363.2017.1299682 . Critical Reviews in Clinical Laboratory Sciences
Mitochondrial traffic jams in Alzheimer's disease - pinpointing the roadblocks
Correia, S.C.; Perry, G.; Moreira, P.I., 2016. Biochimica et Biophysica Acta - Molecular Basis of Disease. 1909 - 1917. 10. 1862. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84979699672&partnerID=MN8TOARS . 10.1016/j.bbadis.2016.07.010 . Biochimica et Biophysica Acta - Molecular Basis of Disease
Middle-Aged Diabetic Females and Males Present Distinct Susceptibility to Alzheimer Disease-like Pathology
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Alzheimer's Disease: From Mitochondrial Perturbations to Mitochondrial Medicine
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Alzheimer's disease-related misfolded proteins and dysfunctional organelles on autophagy menu
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Cerebrovascular and mitochondrial abnormalities in Alzheimer’s disease: a brief overview
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Type 2 diabetes aggravates alzheimer's disease-associated vascular alterations of the aorta in mice
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Daily consumption of white tea (Camellia sinensis (L.)) improves the cerebral cortex metabolic and oxidative profile in prediabetic Wistar rats
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Kaurane diterpenes as mitochondrial alterations preventive agents under experimental oxidative stress conditions
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Physical exercise improves brain cortex and cerebellum mitochondrial bioenergetics and alters apoptotic, dynamic and auto(mito)phagy markers
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The role of mitochondrial disturbances in Alzheimer, Parkinson and Huntington diseases
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Testosterone deficiency induced by progressive stages of diabetes mellitus impairs glucose metabolism and favors glycogenesis in mature rat Sertoli cells
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Alzheimer's disease and type 2 diabetes-related alterations in brain mitochondria, autophagy and synaptic markers
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Metabolic fingerprints in testicular biopsies from type 1 diabetic patients
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Modulation of endoplasmic reticulum stress: An opportunity to prevent neurodegeneration?
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Metformin in the diabetic brain: friend or foe?
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Can tea consumption be a safe and effective therapy against diabetes mellitus-induced neurodegeneration?
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The role of endoplasmic reticulum in amyloid precursor protein processing and trafficking: Implications for Alzheimer's disease
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Insulin therapy modulates mitochondrial dynamics and biogenesis, autophagy and tau protein phosphorylation in the brain of type 1 diabetic rats
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Enhanced Amyloidogenic Processing of Amyloid Precursor Protein and Cell Death Under Prolonged Endoplasmic Reticulum Stress in Brain Endothelial Cells
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Effects of methylglyoxal and pyridoxamine in rat brain mitochondria bioenergetics and oxidative status
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Cardiolipin profile changes are associated to the early synaptic mitochondrial dysfunction in Alzheimer's disease
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Vascular, oxidative, and synaptosomal abnormalities during aging and the progression of type 2 diabetes
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Insulin as a bridge between type 2 diabetes and alzheimer disease - how anti-diabetics could be a solution for dementia
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Pre-diabetes alters testicular PGC1-a/SIRT3 axis modulating mitochondrial bioenergetics and oxidative stress
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Increased susceptibility to amyloid-ß toxicity in rat brain microvascular endothelial cells under hyperglycemic conditions
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Mitochondrial quality control systems sustain brain mitochondrial bioenergetics in early stages of type 2 diabetes
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Amyloid-Beta Disrupts Calcium and Redox Homeostasis in Brain Endothelial Cells
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Metformin and male reproduction: Effects on Sertoli cell metabolism
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Perspectives on mitochondrial uncoupling proteins-mediated neuroprotection
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Defective HIF signaling pathway and brain response to hypoxia in neurodegenera-tive diseases: Not an Iffy question!
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Insulin-induced recurrent hypoglycemia exacerbates diabetic brain mitochondrial dysfunction and oxidative imbalance
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Mitochondrial-targeted protective properties of isolated diterpenoids from sideritis spp. in response to the deleterious changes induced by H 2O2
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Molecular mechanisms beyond glucose transport in diabetes-related male infertility
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Crosstalk between diabetes and brain: Glucagon-like peptide-1 mimetics as a promising therapy against neurodegeneration
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Hyperglycemia, hypoglycemia and dementia: Role of mitochondria and uncoupling proteins
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Type 2 diabetic and alzheimer's disease mice present similar behavioral, cognitive, and vascular anomalies
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Exposure to 2,4-dichlorophenoxyacetic acid alters glucose metabolism in immature rat Sertoli cells
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Control of Sertoli cell metabolism by sex steroid hormones is mediated through modulation in glycolysis-related transporters and enzymes
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Phosphorylation of tau protein as the link between oxidative stress, mitochondrial dysfunction, and connectivity failure: Implications for Alzheimer's disease
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Neurofilaments are the major neuronal target of hydroxynonenal-mediated protein cross-links
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High-sugar diets, type 2 diabetes and Alzheimer's disease
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Hormonal control of Sertoli cell metabolism regulates spermatogenesis
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UCP2 and ANT differently modulate proton-leak in brain mitochondria of long-term hyperglycemic and recurrent hypoglycemic rats
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Mechanism of inhibition of mitochondrial ATP synthase by 17ß-Estradiol
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Mitochondrial abnormalities in a streptozotocin-induced rat model of sporadic Alzheimer's disease
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Mitochondrial DNA oxidative damage and repair in aging and Alzheimer's disease
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Is exercise-in-a-bottle likely to proffer new insights into Alzheimer's disease?
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Androgen-responsive and nonresponsive prostate cancer cells present a distinct glycolytic metabolism profile
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Hydroxynonenal-generated crosslinking fluorophore accumulation in Alzheimer disease reveals a dichotomy of protein turnover
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The role of iron as a mediator of oxidative stress in Alzheimer disease
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Cyanide preconditioning protects brain endothelial and NT2 neuron-like cells against glucotoxicity: Role of mitochondrial reactive oxygen species and HIF-1a
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Impact of diabetes in blood-testis and blood-brain barriers: Resemblances and differences
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Physical exercise as a possible strategy for brain protection: Evidence from mitochondrial-mediated mechanisms
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Nuclear and mitochondrial DNA oxidation in Alzheimer's disease
Santos, R.X.; Correia, S.C.; Zhu, X.; Lee, H.-G.; Petersen, R.B.; Nunomura, A.; Smith, M.A.; Perry, G.; Moreira, P.I., 2012. Free Radical Research. 565 - 576. 4. 46. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863229887&partnerID=MN8TOARS . 10.3109/10715762.2011.648188 . Free Radical Research
Guidelines for the use and interpretation of assays for monitoring autophagy
Klionsky, D.J.; Abdalla, F.C.; Abeliovich, H.; Abraham, R.T.; Acevedo-Arozena, A.; Adeli, K.; Agholme, L.; et al, 2012. Autophagy. 445 - 544. 4. 8. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862295360&partnerID=MN8TOARS . 10.4161/auto.19496 . Autophagy
The impairment of insulin signaling in Alzheimer's disease
Candeias, E.; Duarte, A.I.; Carvalho, C.; Correia, S.C.; Cardoso, S.; Santos, R.X.; Plácido, A.I.; Perry, G.; Moreira, P.I., 2012. IUBMB Life. 951 - 957. 12. 64. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870197271&partnerID=MN8TOARS . 10.1002/iub.1098 . IUBMB Life
Insulin signaling, glucose metabolism and mitochondria: Major players in Alzheimer's disease and diabetes interrelation
Correia, S.C.; Santos, R.X.; Carvalho, C.; Cardoso, S.; Candeias, E.; Santos, M.S.; Oliveira, C.R.; Moreira, P.I., 2012. Brain Research. 64 - 78. 1441. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857788978&partnerID=MN8TOARS . 10.1016/j.brainres.2011.12.063 . Brain Research
Alzheimer's disease and diabetes: An integrative view of the role of mitochondria, oxidative stress, and insulin
Moreira, P.I., 2012. Journal of Alzheimer's Disease. SUPPL.2. 30. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863002103&partnerID=MN8TOARS . 10.3233/JAD-2011-111127 . Journal of Alzheimer's Disease
Metabolic alterations induced by sucrose intake and Alzheimer's disease promote similar brain mitochondrial abnormalities
Carvalho, C.; Cardoso, S.; Correia, S.C.; Santos, R.X.; Santos, M.S.; Baldeiras, I.; Oliveira, C.R.; Moreira, P.I., 2012. Diabetes. 1234 - 1242. 5. 61. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860599622&partnerID=MN8TOARS . 10.2337/db11-1186 . Diabetes
Glycogen synthase kinase 3: A point of integration in alzheimer's disease and a therapeutic target?
Mondragón-Rodríguez, S.; Perry, G.; Zhu, X.; Moreira, P.I.; Williams, S., 2012. International Journal of Alzheimer's Disease. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863697825&partnerID=MN8TOARS . 10.1155/2012/276803 . International Journal of Alzheimer's Disease
Alzheimer disease as a vascular disorder: Where do mitochondria fit?
Correia, S.C.; Santos, R.X.; Cardoso, S.; Carvalho, C.; Candeias, E.; Duarte, A.I.; Plácido, A.I.; Santos, M.S.; Moreira, P.I., 2012. Experimental Gerontology. 878 - 886. 11. 47. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867725518&partnerID=MN8TOARS . 10.1016/j.exger.2012.07.006 . Experimental Gerontology
Insulin in central nervous system: More than just a peripheral hormone
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Mitochondrial importance in Alzheimer's, Huntington's and Parkinson's diseases
Correia, S.C.; Santos, R.X.; Perry, G.; Zhu, X.; Moreira, P.I.; Smith, M.A., 2012. Advances in Experimental Medicine and Biology. 205 - 221. 724. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859514171&partnerID=MN8TOARS . 10.1007/978-1-4614-0653-2_16 . Advances in Experimental Medicine and Biology
Oxidative damage to RNA in aging and neurodegenerative disorders
Nunomura, A.; Moreira, P.I.; Castellani, R.J.; Lee, H.-G.; Zhu, X.; Smith, M.A.; Perry, G., 2012. Neurotoxicity Research. 231 - 248. 3. 22. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865407887&partnerID=MN8TOARS . 10.1007/s12640-012-9331-x . Neurotoxicity Research
Impact of STZ-induced hyperglycemia and insulin-induced hypoglycemia in plasma amino acids and cortical synaptosomal neurotransmitters
Cardoso, S.; Carvalho, C.; Santos, R.; Correia, S.; Santos, M.S.; Seiça, R.; Oliveira, C.R.; Moreira, P.I., 2011. Synapse. 457 - 466. 6. 65. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953276927&partnerID=MN8TOARS . 10.1002/syn.20863 . Synapse
SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1a Destabilization
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New insights into the mechanisms of mitochondrial preconditioning-triggered neuroprotection
Correia, S.C.; Cardoso, S.; Santos, R.X.; Carvalho, C.; Santos, M.S.; Perry, G.; Smith, M.A.; Moreira, P.I., 2011. Current Pharmaceutical Design. 3381 - 3389. 31. 17. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80055089996&partnerID=MN8TOARS . 10.2174/138161211798072490 . Current Pharmaceutical Design
Mitophagy in neurodegeneration: An opportunity for therapy?
Santos, R.X.; Correia, S.C.; Carvalho, C.; Cardoso, S.; Santos, M.S.; Moreira, P.I., 2011. Current Drug Targets. 790 - 799. 6. 12. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955585040&partnerID=MN8TOARS . 10.2174/138945011795528813 . Current Drug Targets
Oxidative Stress and Balance in Neurodegenerative Diseases
Collins, G.H.; Mondragón-Rodríguez, S.; Nunomura, A.; Zhu, X.; Moreira, P.I.; Smith, M.A., 2011. Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders: Second Edition. 10 - 12. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886036204&partnerID=MN8TOARS . 10.1002/9781444341256.ch3 . Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders: Second Edition
Mitochondria as potential targets in antidiabetic therapy
Moreira, P.I.; Oliveira, C.R., 2011. Handbook of Experimental Pharmacology. 331 - 356. 203. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955615960&partnerID=MN8TOARS . 10.1007/978-3-642-17214-4-14 . Handbook of Experimental Pharmacology
Association of mitochondrial signaling in Alzheimer's disease and hypoxia
Carvalho, C.; Correia, S.C.; Santos, R.X.; Cardoso, S.; Moreira, P.I.; Zhu, X.; Smith, M.A.; Perry, G., 2011. Molecular Aspects of Neurodegeneration and Neuroprotection. 50 - 61. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884443449&partnerID=MN8TOARS . 10.2174/978160805092511101010050 . Molecular Aspects of Neurodegeneration and Neuroprotection
Neurofilamentopathy in neurodegenerative diseases
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Using biology to untie the Gordian knot of Alzheimer's disease
Perry, G.; Smith, M.A.; Casadesus, G.; Lee, H.-G.; Moreira, P.I.; Castellani, R.J.; Zhu, X., 2011. Journal of Alzheimer's Disease. SUPPL. 1. 23. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952176838&partnerID=MN8TOARS . 10.3233/JAD-2011-001433 . Journal of Alzheimer's Disease
Mitochondria from distinct tissues are differently affected by 17ß-estradiol and tamoxifen
Moreira, P.I.; Custódio, J.B.A.; Nunes, E.; Oliveira, P.J.; Moreno, A.; Seia, R.; Oliveira, C.R.; Santos, M.S., 2011. Journal of Steroid Biochemistry and Molecular Biology. 8 - 16. 1-2. 123. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650578395&partnerID=MN8TOARS . 10.1016/j.jsbmb.2010.09.004 . Journal of Steroid Biochemistry and Molecular Biology
Effects of rapamycin and TOR on aging and memory: Implications for Alzheimer's disease
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Mitochondrial preconditioning: A potential neuroprotective strategy
Correia, S.C.; Carvalho, C.; Cardoso, S.; Santos, R.X.; Santos, M.S.; Oliveira, C.R.; Perry, G.; et al, 2010. Frontiers in Aging Neuroscience. AUG. 2. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955962818&partnerID=MN8TOARS . 10.3389/fnagi.2010.00138 . Frontiers in Aging Neuroscience
Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology
Moreira, P.I.; Carvalho, C.; Zhu, X.; Smith, M.A.; Perry, G., 2010. Biochimica et Biophysica Acta - Molecular Basis of Disease. 2 - 10. 1. 1802. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-71749121998&partnerID=MN8TOARS . 10.1016/j.bbadis.2009.10.006 . Biochimica et Biophysica Acta - Molecular Basis of Disease
Alzheimer's Disease: An Overview
Moreira, P.I.; Zhu, X.; Smith, M.A.; Perry, G.; Castellani, R.J., 2010. Encyclopedia of Neuroscience. 259 - 263. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-84882903387&partnerID=MN8TOARS . 10.1016/B978-008045046-9.00544-1 . Encyclopedia of Neuroscience
Mitochondrial control of autophagic lysosomal pathway in Alzheimer's disease
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Targeting autophagy in the brain: A promising approach?
Santos, R.X.; Cardoso, S.; Correia, S.; Carvalho, C.; Santos, M.S.; Moreira, P.I., 2010. Central Nervous System Agents in Medicinal Chemistry. 158 - 168. 2. 10. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953681716&partnerID=MN8TOARS . Central Nervous System Agents in Medicinal Chemistry
Detection and localization of markers of oxidative stress by in situ methods: application in the study of Alzheimer disease.
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Mitochondria: A therapeutic target in neurodegeneration
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Cortical and hippocampal mitochondria bioenergetics and oxidative status during hyperglycemia and/or insulin-induced hypoglycemia
Cardoso, S.; Santos, M.S.; Seiça, R.; Moreira, P.I., 2010. Biochimica et Biophysica Acta - Molecular Basis of Disease. 942 - 951. 11. 1802. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956710094&partnerID=MN8TOARS . 10.1016/j.bbadis.2010.07.001 . Biochimica et Biophysica Acta - Molecular Basis of Disease
Alzheimer's disease: Diverse aspects of mitochondrial malfunctioning
Santos, R.X.; Correia, S.C.; Wang, X.; Perry, G.; Smith, M.A.; Moreira, P.I.; Zhu, X., 2010. International Journal of Clinical and Experimental Pathology. 570 - 581. 6. 3. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956026971&partnerID=MN8TOARS . International Journal of Clinical and Experimental Pathology
Autophagy in Alzheimers disease
Moreira, P.I.; Santos, R.X.; Zhu, X.; Lee, H.-G.; Smith, M.A.; Casadesus, G.; Perry, G., 2010. Expert Review of Neurotherapeutics. 1209 - 1218. 7. 10. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954196784&partnerID=MN8TOARS . 10.1586/ern.10.84 . Expert Review of Neurotherapeutics
Effects of estrogen in the brain: Is it a neuroprotective agent in alzheimer's disease?
Correia, S.C.; Santos, R.X.; Cardoso, S.; Carvalho, C.; Santos, M.S.; Oliveira, C.R.; Moreira, P.I., 2010. Current Aging Science. 113 - 126. 2. 3. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953736213&partnerID=MN8TOARS . 10.2174/1874609811003020113 . Current Aging Science
Hypoxia-inducible factor 1: A new hope to counteract neurodegeneration?
Correia, S.C.; Moreira, P.I., 2010. Journal of Neurochemistry. 1 - 12. 1. 112. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-71649085107&partnerID=MN8TOARS . 10.1111/j.1471-4159.2009.06443.x . Journal of Neurochemistry
Mitochondrial dysfunction and oxidative stress in Alzheimer's disease
Moreira, P.I., 2010. European Neurological Review. 17 - 21. 1. 5. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-84858166678&partnerID=MN8TOARS . European Neurological Review
Chronic hypoxia potentiates age-related oxidative imbalance in brain vessels and synaptosomes
Carvalho, C.; Santos, M.S.; Baldeiras, I.; Oliveira, C.R.; Seiça, R.; Moreira, P.I., 2010. Current Neurovascular Research. 288 - 300. 4. 7. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650657043&partnerID=MN8TOARS . Current Neurovascular Research
A synergistic dysfunction of mitochondrial fission/fusion dynamics and mitophagy in Alzheimer's disease
Santos, R.X.; Correia, S.C.; Wang, X.; Perry, G.; Smith, M.A.; Moreira, P.I.; Zhu, X., 2010. Journal of Alzheimer's Disease. SUPPL.2. 20. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956199031&partnerID=MN8TOARS . 10.3233/JAD-2010-100666 . Journal of Alzheimer's Disease
Mitochondria: The missing link between preconditioning and neuroprotection
Correia, S.C.; Santos, R.X.; Perry, G.; Zhu, X.; Moreira, P.I.; Smith, M.A., 2010. Journal of Alzheimer's Disease. SUPPL.2. 20. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956220265&partnerID=MN8TOARS . 10.3233/JAD-2010-100669 . Journal of Alzheimer's Disease
Role of mitochondrial-mediated signaling pathways in Alzheimer disease and hypoxia
Carvalho, C.; Correia, S.C.; Santos, R.X.; Cardoso, S.; Moreira, P.I.; Clark, T.A.; Zhu, X.; Smith, M.A.; Perry, G., 2009. Journal of Bioenergetics and Biomembranes. 433 - 440. 5. 41. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-70449397210&partnerID=MN8TOARS . 10.1007/s10863-009-9247-1 . Journal of Bioenergetics and Biomembranes
Mitochondria as a therapeutic target in Alzheimer's disease and diabetes
Moreira, P.I.; Cardoso, S.M.; Pereira, C.M.; Santos, M.S.; Oliveira, C.R., 2009. CNS and Neurological Disorders - Drug Targets. 492 - 511. 6. 8. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-75849136180&partnerID=MN8TOARS . 10.2174/187152709789824651 . CNS and Neurological Disorders - Drug Targets
Altered redox balance in disease: Can we change the new equilibria?
Perry, G.; Xiongvei, Z.; Moreira, P.I.; Smith, M.A., 2009. Annals of Neurology. 121 - 122. 2. 65. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-62549117802&partnerID=MN8TOARS . 10.1002/ana.21608 . Annals of Neurology
Natural oxidant balance in Parkinson disease
Perry, G.; Moreira, P.I.; Siedlak, S.L.; Nunomura, A.; Zhu, X.; Smith, M.A., 2009. Archives of Neurology. 12. 66. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-73549092919&partnerID=MN8TOARS . 10.1001/archneurol.2009.261 . Archives of Neurology
Food deprivation promotes oxidative imbalance in rat brain
Santos, R.X.; Cardoso, S.; Silva, S.; Correia, S.; Carvalho, C.; Crisóstomo, J.; Rodrigues, L.; et al, 2009. Journal of Food Science. 1. 74. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-58649112769&partnerID=MN8TOARS . 10.1111/j.1750-3841.2008.00982.x . Journal of Food Science
An integrative view of the role of oxidative stress, mitochondria and insulin in Alzheimer's disease
Moreira, P.I.; Duarte, A.I.; Santos, M.S.; Rego, A.C.; Oliveira, C.R., 2009. Journal of Alzheimer's Disease. 741 - 761. 4. 16. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-67649687039&partnerID=MN8TOARS . 10.3233/JAD-2009-0972 . Journal of Alzheimer's Disease
Insulin is a two-edged knife on the brain
Cardoso, S.; Correia, S.; Santos, R.X.; Carvalho, C.; Santos, M.S.; Oliveira, C.R.; Perry, G.; et al, 2009. Journal of Alzheimer's Disease. 483 - 507. 3. 18. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-75249106915&partnerID=MN8TOARS . Journal of Alzheimer's Disease
Doxorubicin: The good, the bad and the ugly effect
Carvalho, C.; Santos, R.X.; Cardoso, S.; Correia, S.; Oliveira, P.J.; Santos, M.S.; Moreira, P.I., 2009. Current Medicinal Chemistry. 3267 - 3285. 25. 16. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-70450215499&partnerID=MN8TOARS . 10.2174/092986709788803312 . Current Medicinal Chemistry
RNA oxidation in Alzheimer disease and related neurodegenerative disorders
Nunomura, A.; Hofer, T.; Moreira, P.I.; Castellani, R.J.; Smith, M.A.; Perry, G., 2009. Acta Neuropathologica. 151 - 166. 1. 118. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-67349251839&partnerID=MN8TOARS . 10.1007/s00401-009-0508-1 . Acta Neuropathologica
Therapeutic opportunities in Alzheimer disease: Current concepts
Marlatt, M.W.; Moreira, P.I.; Lee, H.-g.; Casadesus, G.; Castellani, R.J.; Takeda, A.; Nunomura, A.; et al, 2009. Frontiers in Medicinal Chemistry. 767 - 788. 1. 4. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880176698&partnerID=MN8TOARS . Frontiers in Medicinal Chemistry
Oxidative stress signaling in Alzheimer's disease
Su, B.; Wang, X.; Nunomura, A.; Moreira, P.I.; Lee, H.-G.; Perry, G.; Smith, M.A.; Zhu, X., 2008. Current Alzheimer Research. 525 - 532. 6. 5. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-58049202374&partnerID=MN8TOARS . 10.2174/156720508786898451 . Current Alzheimer Research
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
Klionsky, D.J.; Abeliovich, H.; Agostinis, P.; Agrawal, D.K.; Aliev, G.; Askew, D.S.; Baba, M.; et al, 2008. Autophagy. 151 - 175. 2. 4. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-38949108670&partnerID=MN8TOARS . Autophagy
Metformin protects the brain against the oxidative imbalance promoted by type 2 diabetes
Correia, S.; Carvalho, C.; Santos, M.S.; Proença, T.; Nunes, E.; Duarte, A.I.; Monteiro, P.; et al, 2008. Medicinal Chemistry. 358 - 364. 4. 4. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-50049125341&partnerID=MN8TOARS . 10.2174/157340608784872299 . Medicinal Chemistry
Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease
Resende, R.; Moreira, P.I.; Proença, T.; Deshpande, A.; Busciglio, J.; Pereira, C.; Oliveira, C.R., 2008. Free Radical Biology and Medicine. 2051 - 2057. 12. 44. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-43849096294&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2008.03.012 . Free Radical Biology and Medicine
Sublethal RNA oxidation as a mechanism for neurodegenerative disease
Castellani, R.J.; Nunomura, A.; Rolston, R.K.; Moreira, P.I.; Takeda, A.; Perry, G.; Smith, M.A., 2008. International Journal of Molecular Sciences. 789 - 806. 5. 9. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-44649138016&partnerID=MN8TOARS . 10.3390/ijms9050789 . International Journal of Molecular Sciences
Mechanisms of action of metformin in type 2 diabetes and associated complications: an overview.
Correia, S.; Carvalho, C.; Santos, M.S.; Seiça, R.; Oliveira, C.R.; Moreira, P.I., 2008. Mini reviews in medicinal chemistry. 1343 - 1354. 13. 8. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-58149377770&partnerID=MN8TOARS . 10.2174/138955708786369546 . Mini reviews in medicinal chemistry
Nucleic acid oxidation in Alzheimer disease
Moreira, P.I.; Nunomura, A.; Nakamura, M.; Takeda, A.; Shenk, J.C.; Aliev, G.; Smith, M.A.; Perry, G., 2008. Free Radical Biology and Medicine. 1493 - 1505. 8. 44. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-41149166082&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2008.01.002 . Free Radical Biology and Medicine
Alzheimer disease and the role of free radicals in the pathogenesis of the disease
Moreira, P.I.; Santos, M.S.; Oliveira, C.R.; Shenk, J.C.; Nunomura, A.; Smith, M.A.; Zhu, X.; Perry, G., 2008. CNS and Neurological Disorders - Drug Targets. 3 - 10. 1. 7. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-42049116923&partnerID=MN8TOARS . 10.2174/187152708783885156 . CNS and Neurological Disorders - Drug Targets
Doxorubicin increases the susceptibility of brain mitochondria to Ca2+-induced permeability transition and oxidative damage
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Antioxidant therapy in Alzheimer's disease: theory and practice.
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Metformin promotes isolated rat liver mitochondria impairment
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Amyloid-ß overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins
Wang, X.; Su, B.; Siedlak, S.L.; Moreira, P.I.; Fujioka, H.; Wang, Y.; Casadesus, G.; Zhu, X., 2008. Proceedings of the National Academy of Sciences of the United States of America. 19318 - 19323. 49. 105. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-58049218922&partnerID=MN8TOARS . 10.1073/pnas.0804871105 . Proceedings of the National Academy of Sciences of the United States of America
Neuropathology and treatment of Alzheimer disease: Did we lose the forest for the trees?
Castellani, R.J.; Zhu, X.; Lee, H.-G.; Moreira, P.I.; Perry, G.; Smith, M.A., 2007. Expert Review of Neurotherapeutics. 473 - 485. 5. 7. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34248326079&partnerID=MN8TOARS . 10.1586/14737175.7.5.473 . Expert Review of Neurotherapeutics
Indices of metabolic dysfunction and oxidative stress
Casadesus, G.; Moreira, P.I.; Nunomura, A.; Siedlak, S.L.; Bligh-Glover, W.; Balraj, E.; Petot, G.; Smith, M.A.; Perry, G., 2007. Neurochemical Research. 717 - 722. 4-5. 32. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947593456&partnerID=MN8TOARS . 10.1007/s11064-007-9296-y . Neurochemical Research
Prevention and treatment of Alzheimer disease and aging: Antioxidants
Liu, Q.; Xie, F.; Rolston, R.; Moreira, P.I.; Nunomura, A.; Zhu, X.; Smith, M.A.; Perry, G., 2007. Mini-Reviews in Medicinal Chemistry. 171 - 180. 2. 7. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-33847776693&partnerID=MN8TOARS . 10.2174/138955707779802552 . Mini-Reviews in Medicinal Chemistry
Vascular oxidative stress in Alzheimer disease
Zhu, X.; Smith, M.A.; Honda, K.; Aliev, G.; Moreira, P.I.; Nunomura, A.; Casadesus, G.; et al, 2007. Journal of the Neurological Sciences. 240 - 246. 1-2. 257. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34249776958&partnerID=MN8TOARS . 10.1016/j.jns.2007.01.039 . Journal of the Neurological Sciences
Estradiol affects liver mitochondrial function in ovariectomized and tamoxifen-treated ovariectomized female rats
Moreira, P.I.; Custódio, J.B.A.; Nunes, E.; Moreno, A.; Seiça, R.; Oliveira, C.R.; Santos, M.S., 2007. Toxicology and Applied Pharmacology. 102 - 110. 1. 221. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34247869542&partnerID=MN8TOARS . 10.1016/j.taap.2007.02.006 . Toxicology and Applied Pharmacology
Iron: The redox-active center of oxidative stress in Alzheimer disease
Castellani, R.J.; Moreira, P.I.; Liu, G.; Dobson, J.; Perry, G.; Smith, M.A.; Zhu, X., 2007. Neurochemical Research. 1640 - 1645. 10. 32. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548744723&partnerID=MN8TOARS . 10.1007/s11064-007-9360-7 . Neurochemical Research
Soybean oil treatment impairs glucose-stimulated insulin secretion and changes fatty acid composition of normal and diabetic islets
Nunes, E.; Peixoto, F.; Louro, T.; Sena, C.M.; Santos, M.S.; Matafome, P.; Moreira, P.I.; Seiça, R., 2007. Acta Diabetologica. 121 - 130. 3. 44. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548177719&partnerID=MN8TOARS . 10.1007/s00592-007-0252-8 . Acta Diabetologica
Erratum: Autophagocytosis of mitochondria is prominent in Alzheimer disease (Journal of Neuropathology and Experimental Neurology (2007) 66, (525-532))
Moreira, P.I.; Siedlak, S.L.; Wang, X.; Santos, M.S.; Oliveira, C.R.; Tabaton, M.; Nunomura, A.; et al, 2007. Journal of Neuropathology and Experimental Neurology. 7. 66. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34447321588&partnerID=MN8TOARS . 10.1097/01.jnen.0000263876.99435.cb . Journal of Neuropathology and Experimental Neurology
Neuronal death and survival under oxidative stress in Alzheimer and Parkinson diseases
Nunomura, A.; Moreira, P.I.; Lee, H.G.; Zhu, X.; Castellani, R.J.; Smith, M.A.; Perry, G., 2007. CNS and Neurological Disorders - Drug Targets. 411 - 423. 6. 6. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-41749088686&partnerID=MN8TOARS . 10.2174/187152707783399201 . CNS and Neurological Disorders - Drug Targets
Erratum: Increased autophagic degradation of mitochondria in Alzheimer disease (Autophagy)
Moreira, P.I.; Siedlak, S.L.; Wang, X.; Santos, M.S.; Oliveira, C.R.; Tabaton, M.; Nunomura, A.; et al, 2007. Autophagy. 614 - 615. 6. 3. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-35848931249&partnerID=MN8TOARS . Autophagy
Lipoic acid and N-acetyl cysteine decrease mitochondrial-related oxidative stress in Alzheimer disease patient fibroblasts
Moreira, P.I.; Harris, P.L.R.; Zhu, X.; Santos, M.S.; Oliveira, C.R.; Smith, M.A.; Perry, G., 2007. Journal of Alzheimer's Disease. 195 - 206. 2. 12. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34848890388&partnerID=MN8TOARS . Journal of Alzheimer's Disease
The key role of oxidative stress in alzheimer's disease
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Autophagocytosis of mitochondria is prominent in Alzheimer disease
Moreira, P.I.; Siedlak, S.L.; Wang, X.; Santos, M.S.; Oliveira, C.R.; Tabaton, M.; Nunomura, A.; et al, 2007. Journal of Neuropathology and Experimental Neurology. 525 - 532. 6. 66. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34249881080&partnerID=MN8TOARS . 10.1097/01.jnen.0000240476.73532.b0 . Journal of Neuropathology and Experimental Neurology
Brain mitochondrial dysfunction as a link between Alzheimer's disease and diabetes
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Oxidative RNA damage and neurodegeneration
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Neurodegeneration in Alzheimer's disease: Inter-organelle cross-talk and oxidative stress in cell life and death decisions
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Alzheimer's disease: A lesson from mitochondrial dysfunction
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Compensatory responses induced by oxidative stress in Alzheimer disease
Moreira, P.I.; Zhu, X.; Liu, Q.; Honda, K.; Siedlak, S.L.; Harris, P.L.; Smith, M.A.; Perry, G., 2006. Biological Research. 7 - 13. 1. 39. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745840777&partnerID=MN8TOARS . Biological Research
Mitochondrial abnormalities and oxidative imbalance in Alzheimer disease
Zhu, X.; Perry, G.; Moreira, P.I.; Aliev, G.; Cash, A.D.; Hirai, K.; Smith, M.A., 2006. Journal of Alzheimer's Disease. 147 - 153. 2. 9. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33746089859&partnerID=MN8TOARS . Journal of Alzheimer's Disease
Presenilin mutation: A deadly first hit in Alzheimer disease - A commentary on "aging sensitizes towards ROS formation and lipid peroxidation in PS1M146L transgenic mice"
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The (un)balance between metabolic and oxidative abnormalities and cellular compensatory responses in Alzheimer disease
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Neuropathology in Alzheimer's disease: awaking from a hundred-year-old dream.
Nunomura, A.; Castellani, R.J.; Lee, H.G.; Moreira, P.I.; Zhu, X.; Perry, G.; Smith, M.A., 2006. Science of aging knowledge environment : SAGE KE. 8. 2006. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33744531637&partnerID=MN8TOARS . 10.1126/sageke.2006.8.pe10 . Science of aging knowledge environment : SAGE KE
Involvement of oxidative stress in Alzheimer disease
Nunomura, A.; Castellani, R.J.; Zhu, X.; Moreira, P.I.; Perry, G.; Smith, M.A., 2006. Journal of Neuropathology and Experimental Neurology. 631 - 641. 7. 65. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33747861696&partnerID=MN8TOARS . 10.1097/01.jnen.0000228136.58062.bf . Journal of Neuropathology and Experimental Neurology
Brain and brawn: Parallels in oxidative strength
Moreira, P.I.; Honda, K.; Zhu, X.; Nunomura, A.; Casadesus, G.; Smith, M.A.; Perry, G., 2006. Neurology. 2 SUPPL. 1. 66. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644850568&partnerID=MN8TOARS . Neurology
Telomeres and telomerase in Alzheimer's disease: Epiphenomena or a new focus for therapeutic strategy?
Franco, S.; Blasco, M.A.; Siedlak, S.L.; Harris, P.L.R.; Moreira, P.I.; Perry, G.; Smith, M.A., 2006. Alzheimer's and Dementia. 164 - 168. 3. 2. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33744931650&partnerID=MN8TOARS . 10.1016/j.jalz.2006.03.001 . Alzheimer's and Dementia
Insulin attenuates diabetes-related mitochondrial alterations: A comparative study
Moreira, P.I.; Rolo, A.P.; Sena, C.; Seiça, R.; Oliveira, C.R.; Santos, M.S., 2006. Medicinal Chemistry. 299 - 308. 3. 2. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33746153746&partnerID=MN8TOARS . 10.2174/157340606776930754 . Medicinal Chemistry
The key role of mitochondria in Alzheimer's disease
Moreira, P.I.; Cardoso, S.M.; Santos, M.S.; Oliveira, C.R., 2006. Journal of Alzheimer's Disease. 101 - 110. 2. 9. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33746066329&partnerID=MN8TOARS . Journal of Alzheimer's Disease
Therapeutic options in Alzheimer's disease
Moreira, P.I.; Zhu, X.; Nunomura, A.; Smith, M.A.; Perry, G., 2006. Expert Review of Neurotherapeutics. 897 - 910. 6. 6. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745486884&partnerID=MN8TOARS . 10.1586/14737175.6.6.897 . Expert Review of Neurotherapeutics
Foreword: Mitochondria in Alzheimer disease
Moreira, P.I.; Oliveira, C., 2006. Journal of Alzheimer's Disease. 2. 9. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33746065622&partnerID=MN8TOARS . Journal of Alzheimer's Disease
Tamoxifen and estradiol interact with the flavin mononucleotide site of complex I leading to mitochondrial failure
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Oxidative stress mechanisms and potential therapeutics in Alzheimer disease
Moreira, P.I.; Siedlak, S.L.; Aliev, G.; Zhu, X.; Cash, A.D.; Smith, M.A.; Perry, G., 2005. Journal of Neural Transmission. 921 - 932. 7. 112. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-20944449836&partnerID=MN8TOARS . 10.1007/s00702-004-0242-8 . Journal of Neural Transmission
Mitogen- and stress-activated protein kinase 1: Convergence of the ERK and p38 pathways in Alzheimer's disease
Webber, K.M.; Smith, M.A.; Lee, H.-G.; Harris, P.L.; Moreira, P.; Perry, G.; Zhu, X., 2005. Journal of Neuroscience Research. 554 - 560. 4. 79. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-14144250344&partnerID=MN8TOARS . 10.1002/jnr.20380 . Journal of Neuroscience Research
Chronological primacy of oxidative stress in Alzheimer disease
Smith, M.A.; Nunomura, A.; Lee, H.-G.; Zhu, X.; Moreira, P.I.; Avila, J.; Perry, G., 2005. Neurobiology of Aging. 579 - 580. 5. 26. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-13644249113&partnerID=MN8TOARS . 10.1016/j.neurobiolaging.2004.09.021 . Neurobiology of Aging
Alzheimer's disease and oxidative stress: The old problem remains unsolved
Moreira, P.I.; Honda, K.; Liu, Q.; Aliev, G.; Oliveira, C.R.; Santos, M.S.; Zhu, X.; Smith, M.A.; Perry, G., 2005. Current Medicinal Chemistry - Central Nervous System Agents. 51 - 62. 1. 5. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-15344351142&partnerID=MN8TOARS . Current Medicinal Chemistry - Central Nervous System Agents
Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations
Liu, Q.; Smith, M.A.; Avilá, J.; DeBernardis, J.; Kansal, M.; Takeda, A.; Zhu, X.; et al, 2005. Free Radical Biology and Medicine. 746 - 754. 6. 38. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-13844267510&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2004.11.005 . Free Radical Biology and Medicine
Oxidative damage and Alzheimer's disease: Are antioxidant therapies useful?
Moreira, P.I.; Smith, M.A.; Zhu, X.; Honda, K.; Lee, H.-G.; Aliev, G.; Perry, G., 2005. Drug News and Perspectives. 13 - 19. 1. 18. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-17444377148&partnerID=MN8TOARS . 10.1358/dnp.2005.18.1.877165 . Drug News and Perspectives
A second look into the oxidant mechanisms in Alzheimer's disease
Moreira, P.I.; Oliveira, C.R.; Santos, M.S.; Nunomura, A.; Honda, K.; Zhu, X.; Smith, M.A.; Perry, G., 2005. Current Neurovascular Research. 179 - 184. 2. 2. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-18744402471&partnerID=MN8TOARS . 10.2174/1567202053586758 . Current Neurovascular Research
Tau phosphorylation in Alzheimer's disease: Pathogen or protector?
Lee, H.-G.; Perry, G.; Moreira, P.I.; Garrett, M.R.; Liu, Q.; Zhu, X.; Takeda, A.; Nunomura, A.; Smith, M.A., 2005. Trends in Molecular Medicine. 164 - 169. 4. 11. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-17044435830&partnerID=MN8TOARS . 10.1016/j.molmed.2005.02.008 . Trends in Molecular Medicine
Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron
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Therapeutic opportunities in Alzheimer Disease: One for all or all for one?
Marlatt, M.W.; Webber, K.M.; Moreira, P.I.; Lee, H.-G.; Casadesus, G.; Honda, K.; Zhu, X.; Perry, G.; Smith, M.A., 2005. Current Medicinal Chemistry. 1137 - 1147. 10. 12. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-18544380930&partnerID=MN8TOARS . 10.2174/0929867053764644 . Current Medicinal Chemistry
Alzheimer's disease: An intracellular movement disorder?
Zhu, X.; Moreira, P.I.; Smith, M.A.; Perry, G., 2005. Trends in Molecular Medicine. 391 - 393. 9. 11. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-24344483065&partnerID=MN8TOARS . 10.1016/j.molmed.2005.07.002 . Trends in Molecular Medicine
CoQ10 therapy attenuates amyloid ß-peptide toxicity in brain mitochondria isolated from aged diabetic rats
Moreira, P.I.; Santos, M.S.; Sena, C.; Nunes, E.; Seiça, R.; Oliveira, C.R., 2005. Experimental Neurology. 112 - 119. 1. 196. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-26244447857&partnerID=MN8TOARS . 10.1016/j.expneurol.2005.07.012 . Experimental Neurology
Oxidative stress: The old enemy in Alzheimer's disease pathophysiology
Moreira, P.I.; Honda, K.; Liu, Q.; Santos, M.S.; Oliveira, C.R.; Aliev, G.; Nunomura, A.; et al, 2005. Current Alzheimer Research. 403 - 408. 4. 2. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-24644443839&partnerID=MN8TOARS . 10.2174/156720505774330537 . Current Alzheimer Research
Redox active iron at the center of oxidative stress in Alzheimer disease
Honda, K.; Moreira, P.I.; Liu, Q.; Siedlak, S.L.; Zhu, X.; Smith, M.A.; Perry, G., 2005. Letters in Drug Design and Discovery. 479 - 482. 6. 2. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-24744432930&partnerID=MN8TOARS . 10.2174/1570180054771545 . Letters in Drug Design and Discovery
Oxidative stress and neurodegeneration
Moreira, P.I.; Smith, M.A.; Zhu, X.; Nunomura, A.; Castellani, R.J.; Perry, G., 2005. Annals of the New York Academy of Sciences. 545 - 552. 1043. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-23744439419&partnerID=MN8TOARS . 10.1196/annals.1333.062 . Annals of the New York Academy of Sciences
Metal ions and oxidative protein modification in neurological disease
Sayre, L.M.; Moreira, P.I.; Smith, M.A.; Perry, G., 2005. Annali dell'Istituto Superiore di Sanita. 143 - 164. 2. 41. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-31644435822&partnerID=MN8TOARS . Annali dell'Istituto Superiore di Sanita
Alzheimer's disease-associated neurotoxic mechanisms and neuroprotective strategies
Pereira, C.; Agostinho, P.; Moreira, P.I.; Cardoso, S.M.; Oliveira, C.R., 2005. Current Drug Targets: CNS and Neurological Disorders. 383 - 403. 4. 4. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-23144463734&partnerID=MN8TOARS . 10.2174/1568007054546117 . Current Drug Targets: CNS and Neurological Disorders
Brain mitochondrial injury induced by oxidative stress-related events is prevented by tamoxifen
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Neurodegenerative pathways in Parkinson's disease: Therapeutic strategies
Cardoso, S.M.; Moreira, P.I.; Agostinho, P.; Pereira, C.; Oliveira, C.R., 2005. Current Drug Targets: CNS and Neurological Disorders. 405 - 419. 4. 4. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-23144431757&partnerID=MN8TOARS . 10.2174/1568007054546072 . Current Drug Targets: CNS and Neurological Disorders
Redox metals and oxidative abnormalities in human prion diseases
Petersen, R.B.; Siedlak, S.L.; Lee, H.-G.; Kim, Y.-S.; Nunomura, A.; Tagliavini, F.; Ghetti, B.; et al, 2005. Acta Neuropathologica. 232 - 238. 3. 110. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-26444549058&partnerID=MN8TOARS . 10.1007/s00401-005-1034-4 . Acta Neuropathologica
Insulin protects against amyloid ß-peptide toxicity in brain mitochondria of diabetic rats
Moreira, P.I.; Santos, M.S.; Sena, C.; Seiça, R.; Oliveira, C.R., 2005. Neurobiology of Disease. 628 - 637. 3. 18. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-14744294296&partnerID=MN8TOARS . 10.1016/j.nbd.2004.10.017 . Neurobiology of Disease
Neurofilament proteins in neurodegenerative diseases
Liu, Q.; Xie, F.; Siedlak, S.L.; Nunomura, A.; Honda, K.; Moreira, P.I.; Zhua, X.; Smith, M.A.; Perry, G., 2004. Cellular and Molecular Life Sciences. 3057 - 3075. 24. 61. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-12144265815&partnerID=MN8TOARS . 10.1007/s00018-004-4268-8 . Cellular and Molecular Life Sciences
Staying connected: Synapses in alzheimer disease
Lee, H.-G.; Moreira, P.I.; Zhu, X.; Smith, M.A.; Perry, G., 2004. American Journal of Pathology. 1461 - 1464. 5. 165. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-7244252913&partnerID=MN8TOARS . American Journal of Pathology
Therapeutic potential of oxidant mechanisms in Alzheimer's disease
Moreira, P.I.; Smith, M.A.; Zhu, X.; Santos, M.S.; Oliveira, C.R.; Perry, G., 2004. Expert Review of Neurotherapeutics. 995 - 1004. 6. 4. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-8344235899&partnerID=MN8TOARS . 10.1586/14737175.4.6.995 . Expert Review of Neurotherapeutics
Effect of streptozotocin-induced diabetes on rat brain mitochondria
Moreira, P.I.; Santos, M.S.; Moreno, A.M.; Proença, T.; Seiça, R.; de Oliveira, C.R., 2004. Journal of Neuroendocrinology. 32 - 38. 1. 16. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-0742324515&partnerID=MN8TOARS . 10.1111/j.1365-2826.2004.01107.x . Journal of Neuroendocrinology
Hydroxytamoxifen protects against oxidative stress in brain mitochondria
Moreira, P.I.; Custódio, J.B.; Oliveira, C.R.; Santos, M.S., 2004. Biochemical Pharmacology. 195 - 204. 1. 68. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-2942568021&partnerID=MN8TOARS . 10.1016/j.bcp.2004.03.019 . Biochemical Pharmacology
Neuroprotection strategies: Effect of vinpocetinein in vitro oxidative stress models | Estratégias de neuroprotecção: Efeito da vimpocetina em modelos in vitro de stresse oxidativo
Pereira, C.; Agostinho, P.; Moreira, P.I.; Duarte, A.I.; Santos, M.S.; Oliveira, C.R., 2003. Acta Medica Portuguesa. 401 - 406. 6. 16. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-9644310235&partnerID=MN8TOARS . Acta Medica Portuguesa
Increased vulnerability of brain mitochondria in diabetic (goto-kakizaki) rats with aging and amyloid-ß exposure
Moreira, P.I.; Santos, M.S.; Moreno, A.M.; Seiça, R.; Oliveira, C.R., 2003. Diabetes. 1449 - 1456. 6. 52. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038321341&partnerID=MN8TOARS . 10.2337/diabetes.52.6.1449 . Diabetes
Effect of amyloid ß-peptide on permeability transition pore: A comparative study
Moreira, P.I.; Santos, M.S.; Moreno, A.; Rego, A.C.; Oliveira, C., 2002. Journal of Neuroscience Research. 257 - 267. 2. 69. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037100213&partnerID=MN8TOARS . 10.1002/jnr.10282 . Journal of Neuroscience Research
Amyloid ß-peptide promotes permeability transition pore in brain mitochondria
Moreira, P.I.; Santos, M.S.; Moreno, A.; Oliveira, C., 2001. Bioscience Reports. 789 - 800. 6. 21. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035780141&partnerID=MN8TOARS . 10.1023/A:1015536808304 . Bioscience Reports
Synaptosomal response to oxidative stress: Effect of vinpocetine
Santos, M.S.; Duarte, A.I.; Moreira, P.I.; Oliveira, C.R., 2000. Free Radical Research. 57 - 66. 1. 32. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033988559&partnerID=MN8TOARS . Free Radical Research
Effect of zinc ions on the cytotoxicity induced by the amyloid ß- peptide
Moreira, P.; Pereira, C.; Santos, M.S.; Oliveira, C., 2000. Antioxidants and Redox Signaling. 317 - 325. 2. 2. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033949740&partnerID=MN8TOARS . Antioxidants and Redox Signaling
Susceptibility to ß-amyloid-induced toxicity is decreased in Goto- Kakizaki diabetic rats: Involvement of oxidative stress
Pereira, C.; Moreira, P.; Seiça, R.; Santos, M.S.; Oliveira, C.R., 2000. Experimental Neurology. 383 - 391. 1. 161. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034051172&partnerID=MN8TOARS . 10.1006/exnr.1999.7270 . Experimental Neurology
Effect of Zinc Ions on the Cytotoxicity Induced by the Amyloid beta-Peptide
Moreira, Paula; Pereira, Claudia; Santos, Maria S.; Oliveira, Catarina, 2000. Antioxidants & Redox Signaling. 317 - 325. 2. 2. 2000. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000207500700014&KeyUID=WOS:000207500700014 . 10.1089/ars.2000.2.2-317 . Antioxidants & Redox Signaling
5 243 out of 243 Publications
Stimulus to Research Prize, Calouste Gulbenkian Foundation (PMoreira);
Best Poster Presentation Prize; Physiological Society Spring workshop, The Physiological Society (PMoreira);
L’Oreal for Women in Science, L’Oreal Portugal, UNESCO and Fundação para a Ciência e a Tecnologia (PMoreira);
ASN Neuro Poster Prize, The American Society of Neurochemistry (SCorreia);
“Best Scientific Paper in Basic Science” Prize, Faculty of Medicine, University of Coimbra (SCardoso)
Honorable Mention Pedro Eurico Lisboa / SPD (CCarvalho)
Rosalind Franklin Society Special Award in Science 2022 (PMoreira)
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