A light-triggerable polymeric nanoparticle (NP) library composed of 160 formulations with physicochemical diversity and differential responsiveness to light for delivery of RNA-based therapies.

Physico-chemical diversity: allows the selection of the best NPs considering the cell type being transfected, diminishing the time required for transfection. Some NPs presented cell transfection of 10 min or less.

Differential responsiveness to light: allows the selection of the more efficient NPs in endolysosomal escape after light-triggering the release.