Ana Ledo

Team icon

Researcher

Affiliation

Faculty of Pharmacy, University of Coimbra

Publications

Show less

Information about journal articles, updated at 28-11-2021, from platform CIÊNCIAVITAE.

Microelectrode Sensor for Real-Time Measurements of Nitrite in the Living Brain, in the Presence of Ascorbate

Monteiro, Tiago; Dias, Cândida; Lourenço, Cátia F.; Ledo, Ana; Barbosa, Rui M.; Almeida, M. Gabriela, Biosensors. 8. 11. 2021. http://dx.doi.org/10.3390/bios11080277 . 10.3390/bios11080277 . Biosensors

The bioactivity of neuronal-derived nitric oxide in aging and neurodegeneration: Switching signaling to degeneration

Ledo, A.; Lourenço, C.F.; Cadenas, E.; Barbosa, R.M.; Laranjinha, J., Free Radical Biology and Medicine. 500 - 513. 162. 2021. http://dx.doi.org/10.1016/j.freeradbiomed.2020.11.005 . 10.1016/j.freeradbiomed.2020.11.005 . Free Radical Biology and Medicine

A High Fat/Cholesterol Diet Recapitulates Some Alzheimer's Disease-Like Features in Mice: Focus on Hippocampal Mitochondrial Dysfunction

Mancini, Gianni; Dias, Candida; Lourenço, Catia F.; Laranjinha, Joao; de Bem, Andreza; Ledo, Ana, Journal of Alzheimer's Disease. 1 - 15. 2021. http://dx.doi.org/10.3233/jad-210122 . 10.3233/jad-210122 . Journal of Alzheimer's Disease

The Peculiar Facets of Nitric Oxide as a Cellular Messenger: From Disease-Associated Signaling to the Regulation of Brain Bioenergetics and Neurovascular Coupling

Laranjinha, João; Nunes, Carla; Ledo, Ana; Lourenço, Cátia; Rocha, Bárbara; Barbosa, Rui M., Neurochemical Research. 64 - 76. 1. 46. 2021. http://dx.doi.org/10.1007/s11064-020-03015-0 . 10.1007/s11064-020-03015-0 . published Neurochemical Research

Electrochemical Evaluation of a Multi-Site Clinical Depth Recording Electrode for Monitoring Cerebral Tissue Oxygen

Ledo, Ana; Fernandes, Eliana; Quintero, Jorge E.; Gerhardt, Greg A.; Barbosa, Rui M., Micromachines. 7. 11. 2020. http://dx.doi.org/10.3390/mi11070632 . 10.3390/mi11070632 . Micromachines

An optimized spectrophotometric assay reveals increased activity of enzymes involved in 2-arachidonoyl glycerol turnover in the cerebral cortex of a rat model of Alzheimer’s disease

Rodrigues, Matilde S.; Ferreira, Cláudia; Dias, Cândida; Pliássova, Anna; Souza, Lisiane; Ledo, Ana; Laranjinha, João; Cunha, Rodrigo A.; Köfalvi, Attila, European Journal of Neuroscience. 2020. http://dx.doi.org/10.1111/ejn.14944 . 10.1111/ejn.14944 . European Journal of Neuroscience

Enhanced Selectivity and Stability of Ruthenium Purple-Modified Carbon Fiber Microelectrodes for Detection of Hydrogen Peroxide in Brain Tissue

Ledo, Ana; Fernandes, Eliana; Brett, Christopher M.A.; Barbosa, Rui M.; Ledo, Ana; Brett, Christopher, Sensors and Actuators B: Chemical. 2020. http://dx.doi.org/10.1016/j.snb.2020.127899 . 10.1016/j.snb.2020.127899 . published Sensors and Actuators B: Chemical

Platinized carbon fiber-based glucose microbiosensor designed for metabolic studies in brain slices

Lourenço, Cátia F.; Caetano, Miguel; Ledo, Ana; Barbosa, Rui M., Bioelectrochemistry. 130. 2019. http://dx.doi.org/10.1016/j.bioelechem.2019.06.010 . 10.1016/j.bioelechem.2019.06.010 . Bioelectrochemistry

Concurrent measurements of neurochemical and electrophysiological activity with microelectrode arrays: New perspectives for constant potential amperometry

Ana Ledo; Cátia F. Lourenço; João Laranjinha; Greg A. Gerhardt; Rui M. Barbosa, Current Opinion in Electrochemistry. 129 - 140. 12. 2018. https://www.sciencedirect.com/science/article/pii/S2451910318300073?via%3Dihub . 10.1016/j.coelec.2018.05.018Get . Current Opinion in Electrochemistry

Real-time detection of nitrite in the brain using carbon fiber microelectrodes

Monteiro, Tiago; Dias, Cândida; Lourenço, Cátia F; Ledo, Ana; Laranjinha, João; Barbosa, Rui M.; Almeida, M. Gabriela, Annals of Medicine. S29 - S30. S1. 50. 2018. published Annals of Medicine

Analysis of respiratory capacity in brain tissue preparations: high-resolution respirometry for intact hippocampal slices

Dias, Cândida; Lourenço, Cátia F.; Barbosa, Rui M.; Laranjinha, João; Ledo, Ana, Analytical Biochemistry. 43 - 50. 551. 2018. http://dx.doi.org/10.1016/j.ab.2018.05.010 . 10.1016/j.ab.2018.05.010 . published Analytical Biochemistry

Age-Dependent Impairment of Neurovascular and Neurometabolic Coupling in the Hippocampus

Lourenço, Cátia F.; Ledo, Ana; Caetano, Miguel; Barbosa, Rui M.; Laranjinha, João, Frontiers in Physiology. 9. 2018. http://dx.doi.org/10.3389/fphys.2018.00913 . 10.3389/fphys.2018.00913 . published Frontiers in Physiology

Simultaneous measurements of ascorbate and glutamate in vivo in the rat brain using carbon fiber nanocomposite sensors and microbiosensor arrays

Ferreira, N.R.; Ledo, A.; Laranjinha, J.; Gerhardt, G.A.; Barbosa, R.M., Bioelectrochemistry. 142 - 150. 121. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85041463844&partnerID=MN8TOARS . 10.1016/j.bioelechem.2018.01.009 . published Bioelectrochemistry

Combined in vivo amperometric oximetry and electrophysiology in a single sensor: A tool for epilepsy research

Ledo, A.; Lourenço, C.F.; Laranjinha, J.; Gerhardt, G.A.; Barbosa, R.M., Analytical Chemistry. 12383 - 12390. 21. 89. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85034812431&partnerID=MN8TOARS . 10.1021/acs.analchem.7b03452 . published Analytical Chemistry

Ceramic-Based Multisite Platinum Microelectrode Arrays: Morphological Characteristics and Electrochemical Performance for Extracellular Oxygen Measurements in Brain Tissue

Ledo, A.; Lourenço, C.F.; Laranjinha, J.; Brett, C.M.A.; Gerhardt, G.A.; Barbosa, R.M., Analytical Chemistry. 1674 - 1683. 3. 89. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85026352061&partnerID=MN8TOARS . 10.1021/acs.analchem.6b03772 . published Analytical Chemistry

Neurovascular uncoupling in the triple transgenic model of Alzheimer's disease: Impaired cerebral blood flow response to neuronal-derived nitric oxide signaling

Lourenço, C.F.; Ledo, A.; Barbosa, R.M.; Laranjinha, J., Experimental Neurology. 36 - 43. 291. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85011654048&partnerID=MN8TOARS . 10.1016/j.expneurol.2017.01.013 . published Experimental Neurology

Neurovascular-neuroenergetic coupling axis in the brain: master regulation by nitric oxide and consequences in aging and neurodegeneration

Lourenço, C.F.; Ledo, A.; Barbosa, R.M.; Laranjinha, J., Free Radical Biology and Medicine. 668 - 682. 108. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85018262522&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2017.04.026 . published Free Radical Biology and Medicine

Neurometabolic and electrophysiological changes during cortical spreading depolarization: Multimodal approach based on a lactate-glucose dual microbiosensor arrays

Lourenço, C.F.; Ledo, A.; Gerhardt, G.A.; Laranjinha, J.; Barbosa, R.M., Scientific Reports. 1. 7. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85026399048&partnerID=MN8TOARS . 10.1038/s41598-017-07119-6 . published Scientific Reports

Age-dependent changes in the glutamate-nitric oxide pathway in the hippocampus of the triple transgenic model of Alzheimer's disease: implications for neurometabolic regulation

Dias, Cândida; Lourenço, Cátia F; Ferreiro, Elisabete; Barbosa, Rui M; Laranjinha, João; Ledo, Ana, Neurobiology of Aging. 84 - 95. 1. 46. 2016. 10.1016/j.neurobiolaging.2016.06.012 . published Neurobiology of Aging

Microelectrode array biosensor for high-resolution measurements of extracellular glucose in the brain

Lourenço, Cátia F; Ledo, Ana; Laranjinha, João; Gerhardt, Greg A.; Barbosa, Rui M, Sensors and Actuators B: Chemical. 298 - 307. 1. 237. 2016. 10.1016/j.snb.2016.06.083 . published Sensors and Actuators B: Chemical

Neurovascular and neurometabolic derailment in aging and Alzheimer's disease

Lourenço, Cátia F.; Ledo, Ana; Dias, Cândida; Barbosa, Rui M; Laranjinha, João, Frontiers in Aging Neuroscience. 1 - 8. 103. 7. 2015. 10.3389/fnagi.2015.00103 . published Frontiers in Aging Neuroscience

Age-Associated Changes of Nitric Oxide Concentration Dynamics in the Central Nervous System of Fisher 344 Rats

Ledo, Ana; Lourenço, Cátia F; Caetano, Miguel; Barbosa, Rui M; Laranjinha, João, Cellular and Molecular Neurobiology. 33 - 44. 1. 35. 2014. 10.1007/s10571-014-0115-0 . published Cellular and Molecular Neurobiology

Nitric oxide signaling in the brain: translation of dynamics into respiration control and neurovascular coupling

Laranjinha, João; Santos, Ricardo M.; Lourenço, Cátia F.; Ledo, Ana; Barbosa, Rui M., Annals of the New York Academy of Sciences. 10 - 18. 1. 1259. 2012. 10.1111/j.1749-6632.2012.06582.x . published Annals of the New York Academy of Sciences

Nitric Oxide Inactivation Mechanisms in the Brain: Role in Bioenergetics and Neurodegeneration

Santos, Ricardo M.; Lourenço, Cátia F.; Ledo, Ana; Barbosa, Rui M.; Laranjinha, João, International Journal of Cell Biology. 1 - 13. na. 2012. 2012. 10.1155/2012/391914 . published International Journal of Cell Biology

Preparation, Standardization and Measurement of Nitric Oxide Solutions

Barbosa, Rui M; Jesus, António J.; Santos, Ricardo; Pereira, Cassilda; Lourenço, Cátia F; Rocha, Bárbara; Ferreira, Nuno Ricardo; Ledo, Ana; Laranjinha, Joao, Global Journal of Analytical Chemsitry. 1 - 26. -. 2011. published Global Journal of Analytical Chemsitry

Dynamic and Interacting profiles of ·NO and O2 in rat hippocampal slices

Ledo, Ana; Barbosa, Rui M; Cadenas, Enrique; Laranjinha, Joao, Free Radical Biology and Medicine. 1044 - 1050. 8. 48. 2010. http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T38-4Y7P6TR-4&_user=2656661&_coverDate=04%2F15%2F2010&_rdoc=1&_fmt=high&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000057391&_version=1&_urlVersion=0&_userid=2656661&md5=2c67ecc3f4fd88742b1810 . 10.1016/j.freeradbiomed.2010.01.024 . published Free Radical Biology and Medicine

Coordination of physiologic and toxic pathways in hippocampus by nitric oxide and mitochondria.

Laranjinha, Joao; Ledo, Ana, Frontiers in Bioscience. 1094 - 1106. 1. 12. 2007. http://www.bioscience.org/2007/v12/af/2129/fulltext.htm . 10.2741/2129 . published Frontiers in Bioscience

Regulation in Nitric Oxide Dynamics in Hippocampus by NMDA and AMPA Glutamate Receptors

Ledo, Ana; Frade, João; Barbosa, Rui M; Laranjinha, Joao, Current Topics in Pharmacology. 55 - 70. 2. 10. 2006. published Current Topics in Pharmacology

Electrochemical measurement of endogenously produced nitric oxide in brain slices using Nafion/o-phenylenediamine modified carbon fiber microelectrodes

Ferreira, N.R.; Ledo, A.; Frade, J.G.; Gerhardt, G.A.; Laranjinha, J.; Barbosa, R.M., Analytica Chimica Acta. 1 - 7. 1-2. 535. 2005. 10.1016/j.aca.2004.12.017 . published Analytica Chimica Acta

Concentration dynamics of nitric oxide in rat hippocampal subregions evoked by stimulation of the NMDA glutamate receptor.

Ledo, Ana; Barbosa, Rui M; Gerhardt, G.; Cadenas, Enrique; Laranjinha, Joao, Proceedings of the National Academy of Sciences of the United States of America. 17483 - 17488. 48. 102. 2005. http://www.pnas.org/content/102/48/17483.long . 10.1073/pnas.0503624102 . published Proceedings of the National Academy of Sciences of the United States of America

Nitric oxide in brain: diffusion, targets and concentration dynamics in hippocampal subregions.

Ledo, Ana; Frade, João; Barbosa, Rui M; Laranjinha, Joao, Molecular Aspects in Medicine. 75 - 89. 1-2. 25. 2004. http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T9P-4BY3ND9-2&_user=2656661&_coverDate=04%2F30%2F2004&_rdoc=1&_fmt=high&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=2656661&md5=4c0c44937c20af5c5eb3ae . 10.1016/j.mam.2004.02.010 . published Molecular Aspects in Medicine

Nitric oxide monitoring in hippocampal brain slices using electrochemical methods

Ledo, Ana; Barbosa, Rui M.; Frade, João; Laranjinha, João, Methods in Enzymology. 111 - 125. 359. 2002. published Methods in Enzymology

All projects

Show less

Information of exclusive responsibility of the researcher 28-11-2021 , from platform CIÊNCIAVITAE.

2018/07 -

Cognitive enhancement in aged brain and vascular dementia in humans through improving neurovascular coupling: a mechanism based approach driven by nitrite and ascorbic acid from diet

POCI-01-0145-FEDER-29090

Researcher

CNC.IBILI; Faculdade de Farmacia, Universidade de Coimbra

Funders: Fundação para a Ciência e a Tecnologia; COMPETE2020

2018/07 - 2021/07

Monitoring neurometabolic markers in vivo using microelectrode-based biosensors

POCI-01-0145-FEDER-028261

Researcher

Faculdade de Farmacia, Universidade de Coimbra; CNC.IBILI

Funders: Fundação para a Ciência e a Tecnologia; COMPETE2020

2017/05 - 2019/01

HealthyAging 2020

CENTRO-01-0145-FEDER-000012

Post-doc Fellow

Universidade de Coimbra; CNC.IBILI

Funders: CENTRO2020; PORTUGAL2020; Fundo Europeu de Desenvolvimento Regional

2013/07 - 2015/09

Nitric oxide is a master regulator of brain energetic metabolism: resolving aerobic glycolysis

PTDC/BBB-BQB/3217/2012

Researcher

Funders: Fundação para a Ciência e a Tecnologia; COMPETE2020

2013/05 - 2015/04

A Hipercolesterolemia como factor de risco na doença de Alzheimer: impacto na biodisponibilidade e bioactividade do NO

CAPES/FCT: Bioquimica - 323/13

Principal investigator

Centro de Neurociências e Biologia Celular; Universidade Federal de Santa Catarina

Funders: Fundação para a Ciência e a Tecnologia; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

2012/04 - 2015/03

Nitric Oxide in Alzheimer´s Disease - Signaling Molecule and Mediator of Pathogenesis

PTDC/BIA-BCM/116576/2010

Principal investigator

CNC.IBILI

Funders: Fundação para a Ciência e a Tecnologia; COMPETE2020

2010/04 - 2012/03

Development of a micro-probe for capillary laser Doppler flowmetry in rat brain

PTDC/SAU-NEU/101726/2008

Researcher

Universidade de Coimbra Departamento de Física

Funders: Fundação para a Ciência e a Tecnologia; COMPETE2020

2010/05 - 2013/10

Neurovascular coupling between neuronal activity and blood flow in brain mediated by nitric oxide

PTDC/SAU-NEU/108992/2008

Researcher

CNC.IBILI

Funders: Fundação para a Ciência e a Tecnologia; COMPETE2020

2010/05 - 2013/10

Design of composite chemical sensors and biosensors for real-time and simultaneous monitoring of nitric oxide and oxygen in vivo in the brain.

PTDC/SAU-BEB/103228/2008

Researcher

CNC.IBILI; Universidade de Coimbra

Funders: Fundação para a Ciência e a Tecnologia; COMPETE2020

2010/06 - 2013/06

In vivo dynamics of nitric oxide in the brain: regulation of cellular respiration and implications for Alzheimer´s disease and aging

PTDC/SAU-NEU/103538/2008

Researcher

CNC.IBILI

Funders: Fundação para a Ciência e a Tecnologia; COMPETE2020

2002/03 - 2006/01

Real-time measurement of nitric oxide in hippocampal brain slices: modulation by tissue redox state with implications for neuronal degeneration

POCTI/BCI/42365/2001

PhD Student Fellow

CNC.IBILI; Universidade de Coimbra Faculdade de Farmácia

Funders: Fundação para a Ciência e a Tecnologia

We use cookies to improve your visit to our website.