Publications
Information about journal articles, updated at 15-12-2024, from platform CIÊNCIAVITAE.
Real-time Neurochemical Sensing of Hydrogen Peroxide Production in Brain Tissue using Advanced Nanostructured Au Microelectrodes Functionalized with Ruthenium Purple Film
Ledo, A.; Fernandes, E.; Barbosa, RM., Electrochimica Acta. 512. 2025. https://doi.org/10.1016/j.electacta.2024.145447 . 10.1016/j.electacta.2024.145447 . Electrochimica Acta
Modulation of oxidative neurometabolism in ischemia/reperfusion by nitrite
Dias, Cândida; Lourenço, Cátia F.; Laranjinha, João; Ledo, Ana, Free Radical Biology and Medicine. 218. 2024. http://dx.doi.org/10.1016/j.freeradbiomed.2024.04.172 . 10.1016/j.freeradbiomed.2024.04.172 . Free Radical Biology and Medicine
A biosensor-based approach for the determination of hydrogen peroxide in biological samples
Ledo, Ana; Laranjinha, João; Barbosa, Rui M., Free Radical Biology and Medicine. 218. 2024. http://dx.doi.org/10.1016/j.freeradbiomed.2024.04.112 . 10.1016/j.freeradbiomed.2024.04.112 . Free Radical Biology and Medicine
Amperometric bio-sensing of lactate and oxygen concurrently with local field potentials during status epilepticus
Fernandes, Eliana; Ledo, Ana; Gerhardt, Greg A.; Barbosa, Rui M., Talanta. 268. 2024. http://dx.doi.org/10.1016/j.talanta.2023.125302 . 10.1016/j.talanta.2023.125302 . Talanta
Determination of Hydrogen Peroxide Concentration in Biological Samples: a Biosensor-Based Approach
Ledo, Ana; Baldeiras, Inês; Laranjinha, João; Barbosa, Rui M., Free Radical Biology and Medicine. 41 - 42. 201. 2023. http://dx.doi.org/10.1016/j.freeradbiomed.2023.03.171 . 10.1016/j.freeradbiomed.2023.03.171 . Free Radical Biology and Medicine
Astrocytic Aerobic Glycolysis Provides Lactate to Support Neuronal Oxidative Metabolism in the Hippocampus
Dias, Cândida; Fernandes, Eliana; Barbosa, Rui M.; Laranjinha, João; Ledo, Ana, Biofactors. 2023. in press Biofactors
Design and Evaluation of a Lactate Microbiosensor: Toward Multianalyte Monitoring of Neurometabolic Markers In Vivo in the Brain
Fernandes, Eliana; Ledo, Ana; Barbosa, Rui M., Molecules. 2. 27. 2022. http://dx.doi.org/10.3390/molecules27020514 . 10.3390/molecules27020514 . Molecules
In vivo hydrogen peroxide diffusivity in brain tissue supports volume signaling activity
Ledo, A.; Fernandes, E.; Salvador, A.; Laranjinha, J.; Barbosa, R.M., Redox Biology. 2022. http://dx.doi.org/10.1016/j.redox.2022.102250 . 10.1016/j.redox.2022.102250 . in press Redox Biology
Highly sensitive and selective nanostructured microbiosensors for glucose and lactate simultaneous measurements in blood serum and in vivo in brain tissue
Regiart, Matias; Ledo, Ana; Fernandes, Eliana; Messina, German A.; Brett, Christopher M.A.; Bertotti, Mauro; Barbosa, Rui M., Biosensors and Bioelectronics. 199. 2022. http://dx.doi.org/10.1016/j.bios.2021.113874 . 10.1016/j.bios.2021.113874 . Biosensors and Bioelectronics
A Platinized Carbon Fiber Microelectrode-Based Oxidase Biosensor for Amperometric Monitoring of Lactate in Brain Slices
Dias, Cândida; Fernandes, Eliana; Barbosa, Rui M.; Ledo, Ana, Sensors. 18. 22. 2022. http://dx.doi.org/10.3390/s22187011 . 10.3390/s22187011 . Sensors
Modulation of oxidative neurometabolism in ischemia/reperfusion by nitrite
Dias, C.; Lourenço, C.F.; Laranjinha, J.; Ledo, A., Free Radical Biology and Medicine. 779 - 786. 193. 2022. http://dx.doi.org/10.1016/j.freeradbiomed.2022.11.021 . 10.1016/j.freeradbiomed.2022.11.021 . Free Radical Biology and Medicine
Microelectrode Sensor for Real-Time Measurements of Nitrite in the Living Brain, in the Presence of Ascorbate
Monteiro, Tiago; Dias, Cândida; Lourenço, Cátia F.; Ledo, Ana; Barbosa, Rui M.; Almeida, M. Gabriela, Biosensors. 8. 11. 2021. http://dx.doi.org/10.3390/bios11080277 . 10.3390/bios11080277 . Biosensors
The bioactivity of neuronal-derived nitric oxide in aging and neurodegeneration: Switching signaling to degeneration
Ledo, A.; Lourenço, C.F.; Cadenas, E.; Barbosa, R.M.; Laranjinha, J., Free Radical Biology and Medicine. 500 - 513. 162. 2021. http://dx.doi.org/10.1016/j.freeradbiomed.2020.11.005 . 10.1016/j.freeradbiomed.2020.11.005 . Free Radical Biology and Medicine
A High Fat/Cholesterol Diet Recapitulates Some Alzheimer's Disease-Like Features in Mice: Focus on Hippocampal Mitochondrial Dysfunction
Mancini, Gianni; Dias, Candida; Lourenço, Catia F.; Laranjinha, Joao; de Bem, Andreza; Ledo, Ana, Journal of Alzheimer's Disease. 1 - 15. 2021. http://dx.doi.org/10.3233/jad-210122 . 10.3233/jad-210122 . Journal of Alzheimer's Disease
The Peculiar Facets of Nitric Oxide as a Cellular Messenger: From Disease-Associated Signaling to the Regulation of Brain Bioenergetics and Neurovascular Coupling
Laranjinha, João; Nunes, Carla; Ledo, Ana; Lourenço, Cátia; Rocha, Bárbara; Barbosa, Rui M., Neurochemical Research. 64 - 76. 1. 46. 2021. http://dx.doi.org/10.1007/s11064-020-03015-0 . 10.1007/s11064-020-03015-0 . published Neurochemical Research
Diffusion and Removal Kinetics of Hydrogen Peroxide in Brain Tissue
Ledo, Ana; Fernandes, Eliana; Laranjinha, João; Barbosa, Rui M., Free Radical Biology and Medicine. 165. 2021. http://dx.doi.org/10.1016/j.freeradbiomed.2020.12.326 . 10.1016/j.freeradbiomed.2020.12.326 . published Free Radical Biology and Medicine
Electrochemical Evaluation of a Multi-Site Clinical Depth Recording Electrode for Monitoring Cerebral Tissue Oxygen
Ledo, Ana; Fernandes, Eliana; Quintero, Jorge E.; Gerhardt, Greg A.; Barbosa, Rui M., Micromachines. 7. 11. 2020. http://dx.doi.org/10.3390/mi11070632 . 10.3390/mi11070632 . Micromachines
An optimized spectrophotometric assay reveals increased activity of enzymes involved in 2-arachidonoyl glycerol turnover in the cerebral cortex of a rat model of Alzheimer’s disease
Rodrigues, Matilde S.; Ferreira, Cláudia; Dias, Cândida; Pliássova, Anna; Souza, Lisiane; Ledo, Ana; Laranjinha, João; Cunha, Rodrigo A.; Köfalvi, Attila, European Journal of Neuroscience. 1051 - 1062. 4. 55. 2020. http://dx.doi.org/10.1111/ejn.14944 . 10.1111/ejn.14944 . European Journal of Neuroscience
Enhanced Selectivity and Stability of Ruthenium Purple-Modified Carbon Fiber Microelectrodes for Detection of Hydrogen Peroxide in Brain Tissue
Ledo, Ana; Fernandes, Eliana; Brett, Christopher M.A.; Barbosa, Rui M.; Brett, Christopher, Sensors and Actuators B: Chemical. 2020. http://dx.doi.org/10.1016/j.snb.2020.127899 . 10.1016/j.snb.2020.127899 . published Sensors and Actuators B: Chemical
Platinized carbon fiber-based glucose microbiosensor designed for metabolic studies in brain slices
Lourenço, Cátia F.; Caetano, Miguel; Ledo, Ana; Barbosa, Rui M., Bioelectrochemistry. 130. 2019. http://dx.doi.org/10.1016/j.bioelechem.2019.06.010 . 10.1016/j.bioelechem.2019.06.010 . Bioelectrochemistry
Simultaneous measurements of ascorbate and glutamate in vivo in the rat brain using carbon fiber nanocomposite sensors and microbiosensor arrays
Ferreira, N.R.; Ledo, A.; Laranjinha, J.; Gerhardt, G.A.; Barbosa, R.M., Bioelectrochemistry. 142 - 150. 121. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85041463844&partnerID=MN8TOARS . 10.1016/j.bioelechem.2018.01.009 . published Bioelectrochemistry
Concurrent measurements of neurochemical and electrophysiological activity with microelectrode arrays: New perspectives for constant potential amperometry
Ana Ledo; Cátia F. Lourenço; João Laranjinha; Greg A. Gerhardt; Rui M. Barbosa, Current Opinion in Electrochemistry. 129 - 140. 12. 2018. https://www.sciencedirect.com/science/article/pii/S2451910318300073?via%3Dihub . 10.1016/j.coelec.2018.05.018Get . Current Opinion in Electrochemistry
Age-Dependent Impairment of Neurovascular and Neurometabolic Coupling in the Hippocampus
Lourenço, Cátia F.; Ledo, Ana; Caetano, Miguel; Barbosa, Rui M.; Laranjinha, João, Frontiers in Physiology. 9. 2018. http://dx.doi.org/10.3389/fphys.2018.00913 . 10.3389/fphys.2018.00913 . published Frontiers in Physiology
Real-time detection of nitrite in the brain using carbon fiber microelectrodes
Monteiro, Tiago; Dias, Cândida; Lourenço, Cátia F; Ledo, Ana; Laranjinha, João; Barbosa, Rui M.; Almeida, M. Gabriela, Annals of Medicine. S29 - S30. S1. 50. 2018. published Annals of Medicine
Analysis of respiratory capacity in brain tissue preparations: high-resolution respirometry for intact hippocampal slices
Dias, Cândida; Lourenço, Cátia F.; Barbosa, Rui M.; Laranjinha, João; Ledo, Ana, Analytical Biochemistry. 43 - 50. 551. 2018. http://dx.doi.org/10.1016/j.ab.2018.05.010 . 10.1016/j.ab.2018.05.010 . published Analytical Biochemistry
Neurometabolic and electrophysiological changes during cortical spreading depolarization: Multimodal approach based on a lactate-glucose dual microbiosensor arrays
Lourenço, C.F.; Ledo, A.; Gerhardt, G.A.; Laranjinha, J.; Barbosa, R.M., Scientific Reports. 1. 7. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85026399048&partnerID=MN8TOARS . 10.1038/s41598-017-07119-6 . published Scientific Reports
Neurovascular-neuroenergetic coupling axis in the brain: master regulation by nitric oxide and consequences in aging and neurodegeneration
Lourenço, C.F.; Ledo, A.; Barbosa, R.M.; Laranjinha, J., Free Radical Biology and Medicine. 668 - 682. 108. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85018262522&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2017.04.026 . published Free Radical Biology and Medicine
Neurovascular uncoupling in the triple transgenic model of Alzheimer's disease: Impaired cerebral blood flow response to neuronal-derived nitric oxide signaling
Lourenço, C.F.; Ledo, A.; Barbosa, R.M.; Laranjinha, J., Experimental Neurology. 36 - 43. 291. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85011654048&partnerID=MN8TOARS . 10.1016/j.expneurol.2017.01.013 . published Experimental Neurology
Ceramic-Based Multisite Platinum Microelectrode Arrays: Morphological Characteristics and Electrochemical Performance for Extracellular Oxygen Measurements in Brain Tissue
Ledo, A.; Lourenço, C.F.; Laranjinha, J.; Brett, C.M.A.; Gerhardt, G.A.; Barbosa, R.M., Analytical Chemistry. 1674 - 1683. 3. 89. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85026352061&partnerID=MN8TOARS . 10.1021/acs.analchem.6b03772 . published Analytical Chemistry
Combined in vivo amperometric oximetry and electrophysiology in a single sensor: A tool for epilepsy research
Ledo, A.; Lourenço, C.F.; Laranjinha, J.; Gerhardt, G.A.; Barbosa, R.M., Analytical Chemistry. 12383 - 12390. 21. 89. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85034812431&partnerID=MN8TOARS . 10.1021/acs.analchem.7b03452 . published Analytical Chemistry
Microelectrode array biosensor for high-resolution measurements of extracellular glucose in the brain
Lourenço, Cátia F; Ledo, Ana; Laranjinha, João; Gerhardt, Greg A.; Barbosa, Rui M, Sensors and Actuators B: Chemical. 298 - 307. 1. 237. 2016. 10.1016/j.snb.2016.06.083 . published Sensors and Actuators B: Chemical
Age-dependent changes in the glutamate-nitric oxide pathway in the hippocampus of the triple transgenic model of Alzheimer's disease: implications for neurometabolic regulation
Dias, Cândida; Lourenço, Cátia F; Ferreiro, Elisabete; Barbosa, Rui M; Laranjinha, João; Ledo, Ana, Neurobiology of Aging. 84 - 95. 1. 46. 2016. 10.1016/j.neurobiolaging.2016.06.012 . published Neurobiology of Aging
Neurovascular and neurometabolic derailment in aging and Alzheimer's disease
Lourenço, Cátia F.; Ledo, Ana; Dias, Cândida; Barbosa, Rui M; Laranjinha, João, Frontiers in Aging Neuroscience. 1 - 8. 103. 7. 2015. 10.3389/fnagi.2015.00103 . published Frontiers in Aging Neuroscience
Age-Associated Changes of Nitric Oxide Concentration Dynamics in the Central Nervous System of Fisher 344 Rats
Ledo, Ana; Lourenço, Cátia F; Caetano, Miguel; Barbosa, Rui M; Laranjinha, João, Cellular and Molecular Neurobiology. 33 - 44. 1. 35. 2014. 10.1007/s10571-014-0115-0 . published Cellular and Molecular Neurobiology
Nitric Oxide Inactivation Mechanisms in the Brain: Role in Bioenergetics and Neurodegeneration
Santos, Ricardo M.; Lourenço, Cátia F.; Ledo, Ana; Barbosa, Rui M.; Laranjinha, João, International Journal of Cell Biology. 1 - 13. na. 2012. 2012. 10.1155/2012/391914 . published International Journal of Cell Biology
Nitric oxide signaling in the brain: translation of dynamics into respiration control and neurovascular coupling
Laranjinha, João; Santos, Ricardo M.; Lourenço, Cátia F.; Ledo, Ana; Barbosa, Rui M., Annals of the New York Academy of Sciences. 10 - 18. 1. 1259. 2012. 10.1111/j.1749-6632.2012.06582.x . published Annals of the New York Academy of Sciences
Preparation, Standardization and Measurement of Nitric Oxide Solutions
Barbosa, Rui M; Jesus, António J.; Santos, Ricardo; Pereira, Cassilda; Lourenço, Cátia F; Rocha, Bárbara; Ferreira, Nuno Ricardo; Ledo, Ana; Laranjinha, Joao, Global Journal of Analytical Chemsitry. 1 - 26. -. 2011. published Global Journal of Analytical Chemsitry
Dynamic and Interacting profiles of ·NO and O2 in rat hippocampal slices
Ledo, Ana; Barbosa, Rui M; Cadenas, Enrique; Laranjinha, Joao, Free Radical Biology and Medicine. 1044 - 1050. 8. 48. 2010. http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T38-4Y7P6TR-4&_user=2656661&_coverDate=04%2F15%2F2010&_rdoc=1&_fmt=high&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000057391&_version=1&_urlVersion=0&_userid=2656661&md5=2c67ecc3f4fd88742b1810 . 10.1016/j.freeradbiomed.2010.01.024 . published Free Radical Biology and Medicine
Coordination of physiologic and toxic pathways in hippocampus by nitric oxide and mitochondria.
Laranjinha, Joao; Ledo, Ana, Frontiers in Bioscience. 1094 - 1106. 1. 12. 2007. http://www.bioscience.org/2007/v12/af/2129/fulltext.htm . 10.2741/2129 . published Frontiers in Bioscience
Regulation in Nitric Oxide Dynamics in Hippocampus by NMDA and AMPA Glutamate Receptors
Ledo, Ana; Frade, João; Barbosa, Rui M; Laranjinha, Joao, Current Topics in Pharmacology. 55 - 70. 2. 10. 2006. published Current Topics in Pharmacology
Concentration dynamics of nitric oxide in rat hippocampal subregions evoked by stimulation of the NMDA glutamate receptor.
Ledo, Ana; Barbosa, Rui M; Gerhardt, G.; Cadenas, Enrique; Laranjinha, Joao, Proceedings of the National Academy of Sciences of the United States of America. 17483 - 17488. 48. 102. 2005. http://www.pnas.org/content/102/48/17483.long . 10.1073/pnas.0503624102 . published Proceedings of the National Academy of Sciences of the United States of America
Electrochemical measurement of endogenously produced nitric oxide in brain slices using Nafion/o-phenylenediamine modified carbon fiber microelectrodes
Ferreira, N.R.; Ledo, A.; Frade, J.G.; Gerhardt, G.A.; Laranjinha, J.; Barbosa, R.M., Analytica Chimica Acta. 1 - 7. 1-2. 535. 2005. 10.1016/j.aca.2004.12.017 . published Analytica Chimica Acta
Nitric oxide in brain: diffusion, targets and concentration dynamics in hippocampal subregions.
Ledo, Ana; Frade, João; Barbosa, Rui M; Laranjinha, Joao, Molecular Aspects in Medicine. 75 - 89. 1-2. 25. 2004. http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T9P-4BY3ND9-2&_user=2656661&_coverDate=04%2F30%2F2004&_rdoc=1&_fmt=high&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=2656661&md5=4c0c44937c20af5c5eb3ae . 10.1016/j.mam.2004.02.010 . published Molecular Aspects in Medicine
Nitric oxide monitoring in hippocampal brain slices using electrochemical methods
Ledo, Ana; Barbosa, Rui M.; Frade, João; Laranjinha, João, Methods in Enzymology. 111 - 125. 359. 2002. published Methods in Enzymology
5 44 out of 44 Publications
All projects
Information of exclusive responsibility of the researcher 15-12-2024 , from platform CIÊNCIAVITAE.
2023/03/01 -
The Neurovascular Coupling as a biomarker and a target for cognitive enhancement in aging and vascular dementia through an innovative dietary nitrate-driven nitric oxide redox cycle: a translational study
-
Researcher
Funders: Fundação para a Ciência e a Tecnologia
2021/01/01 - 2025/12/31
Center for Innovative Biomedicine and Biotechnology - Associate Laboratory
LA/P/0058/2020
Universidade de Coimbra
Funders: Fundação para a Ciência e a Tecnologia
2019/01/01 - 2019/12/31
CNC. IBILI
UID/NEU/04539/2019
Universidade de Coimbra Centro de Neurociências e Biologia Celular; Universidade de Coimbra; Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde; Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra
Funders: Fundação para a Ciência e a Tecnologia
2018/07/26 - 2021/07/25
Melhoria cognitiva no cérebro idoso e demência vascular em humanos através da funcionalização do acoplamento neurovascular: uma estratégia mecanística molecular promovida por nitrito e ácido ascórbico da dieta
PTDC/MED-NEU/29099/2017
Universidade de Coimbra; Centro Hospitalar e Universitário de Coimbra EPE; Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Fundação para a Ciência e a Tecnologia
2018/07 -
Cognitive enhancement in aged brain and vascular dementia in humans through improving neurovascular coupling: a mechanism based approach driven by nitrite and ascorbic acid from diet
POCI-01-0145-FEDER-29090
Researcher
CNC.IBILI; Faculdade de Farmacia, Universidade de Coimbra
Funders: Fundação para a Ciência e a Tecnologia; COMPETE2020
2018/07 - 2021/07
Monitoring neurometabolic markers in vivo using microelectrode-based biosensors
POCI-01-0145-FEDER-028261
Researcher
Faculdade de Farmacia, Universidade de Coimbra; CNC.IBILI
Funders: Fundação para a Ciência e a Tecnologia; COMPETE2020
2017/05 - 2019/01
HealthyAging 2020
CENTRO-01-0145-FEDER-000012
Post-doc Fellow
Universidade de Coimbra; CNC.IBILI
Funders: CENTRO2020; PORTUGAL2020; Fundo Europeu de Desenvolvimento Regional
2013/07 - 2015/09
Nitric oxide is a master regulator of brain energetic metabolism: resolving aerobic glycolysis
PTDC/BBB-BQB/3217/2012
Researcher
Funders: Fundação para a Ciência e a Tecnologia; COMPETE2020
2013/05 - 2015/04
A Hipercolesterolemia como factor de risco na doença de Alzheimer: impacto na biodisponibilidade e bioactividade do NO
CAPES/FCT: Bioquimica - 323/13
Principal investigator
Centro de Neurociências e Biologia Celular; Universidade Federal de Santa Catarina
Funders: Fundação para a Ciência e a Tecnologia; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
2012/04 - 2015/03
Nitric Oxide in Alzheimer´s Disease - Signaling Molecule and Mediator of Pathogenesis
PTDC/BIA-BCM/116576/2010
Principal investigator
CNC.IBILI
Funders: Fundação para a Ciência e a Tecnologia; COMPETE2020
2011/01/01 - 2012/12/31
Strategic Project - LA 1 - 2011-2012
PEst-C/SAU/LA0001/2011
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Fundação para a Ciência e a Tecnologia
2010/04 - 2012/03
Development of a micro-probe for capillary laser Doppler flowmetry in rat brain
PTDC/SAU-NEU/101726/2008
Researcher
Universidade de Coimbra Departamento de Física
Funders: Fundação para a Ciência e a Tecnologia; COMPETE2020
2010/05 - 2013/10
Neurovascular coupling between neuronal activity and blood flow in brain mediated by nitric oxide
PTDC/SAU-NEU/108992/2008
Researcher
CNC.IBILI
Funders: Fundação para a Ciência e a Tecnologia; COMPETE2020
2010/05 - 2013/10
Design of composite chemical sensors and biosensors for real-time and simultaneous monitoring of nitric oxide and oxygen in vivo in the brain.
PTDC/SAU-BEB/103228/2008
Researcher
CNC.IBILI; Universidade de Coimbra
Funders: Fundação para a Ciência e a Tecnologia; COMPETE2020
2010/06 - 2013/06
In vivo dynamics of nitric oxide in the brain: regulation of cellular respiration and implications for Alzheimer´s disease and aging
PTDC/SAU-NEU/103538/2008
Researcher
CNC.IBILI
Funders: Fundação para a Ciência e a Tecnologia; COMPETE2020
2002/03 - 2006/01
Real-time measurement of nitric oxide in hippocampal brain slices: modulation by tissue redox state with implications for neuronal degeneration
POCTI/BCI/42365/2001
PhD Student Fellow
CNC.IBILI; Universidade de Coimbra Faculdade de Farmácia
Funders: Fundação para a Ciência e a Tecnologia
5 16 out of 16 projects
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