Diana Filipa Ferreira da Silva

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Researcher

Gut-Brain Axis

Publications

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Information about journal articles, updated at 21-11-2021, from platform CIÊNCIAVITAE.

Microbial BMAA elicits mitochondrial dysfunction, innate immunity activation, and Alzheimer’s disease features in cortical neurons

Silva DF; Candeias, Emanuel; Ana Raquel Esteves; João D Magalhães; I Luisa Ferreira; Daniela Nunes-Costa; A Cristina Rego; Nuno Empadinhas, Journal of Neuroinflammation. 17. 2020. https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-020-02004-y#Abs1 . published Journal of Neuroinflammation

Donepezil-based hybrids as multifunctional anti-Alzheimer's disease chelating agents: Effect of positional isomerization

Costa, Marina; Josselin, Romane; Silva, Diana F.; Cardoso, Sandra M.; May, Nóra V.; Chaves, Sílvia; Santos, M. Amélia, Journal of Inorganic Biochemistry. 2020. http://dx.doi.org/10.1016/j.jinorgbio.2020.111039 . 10.1016/j.jinorgbio.2020.111039 . Journal of Inorganic Biochemistry

The Role of Beclin-1 Acetylation on Autophagic Flux in Alzheimer’s Disease

Esteves, A. Raquel; Filipe, Filipa; Magalhães, João D.; Silva, Diana F.; Cardoso, Sandra M., Molecular Neurobiology. 5654 - 5670. 8. 56. 2019. http://dx.doi.org/10.1007/s12035-019-1483-8 . 10.1007/s12035-019-1483-8 . Molecular Neurobiology

Acetylation as a major determinant to microtubule-dependent autophagy: Relevance to Alzheimer's and Parkinson disease pathology

Esteves, A.R.; Palma, A.M.; Gomes, R.; Santos, D.; Silva, D.F.; Cardoso, S.M., Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2008 - 2023. 8. 1865. 2019. http://dx.doi.org/10.1016/j.bbadis.2018.11.014 . 10.1016/j.bbadis.2018.11.014 . Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Novel tacrine–benzofuran hybrids as potential multi-target drug candidates for the treatment of Alzheimer’s Disease

Fancellu, Gaia; Chand, Karam; Tomás, Daniel; Orlandini, Elisabetta; Piemontese, Luca; Silva, Diana F.; Cardoso, Sandra M.; Chaves, Sílvia; Santos, M. Amélia, Journal of Enzyme Inhibition and Medicinal Chemistry. 211 - 226. 1. 35. 2019. http://dx.doi.org/10.1080/14756366.2019.1689237 . 10.1080/14756366.2019.1689237 . Journal of Enzyme Inhibition and Medicinal Chemistry

Mitochondrial Metabolism Regulates Microtubule Acetylome and Autophagy Trough Sirtuin-2: Impact for Parkinson’s Disease

Esteves, Ana R.; Arduíno, Daniela M.; Silva, Diana F.; Viana, Sofia D.; Pereira, Frederico C.; Cardoso, Sandra M., Molecular Neurobiology. 1440 - 1462. 2. 55. 2017. http://dx.doi.org/10.1007/s12035-017-0420-y . 10.1007/s12035-017-0420-y . Molecular Neurobiology

Mitochondrial Metabolism Power SIRT2-Dependent Deficient Traffic Causing Alzheimer’s-Disease Related Pathology

Silva, D. F.; Esteves, A. R.; Oliveira, C. R.; Cardoso, S. M., Molecular Neurobiology. 4021 - 4040. 6. 54. 2016. http://dx.doi.org/10.1007/s12035-016-9951-x . 10.1007/s12035-016-9951-x . Molecular Neurobiology

Bioenergetic flux, mitochondrial mass and mitochondrial morphology dynamics in AD and MCI cybrid cell lines

Silva, D. F.; Selfridge, J. E.; Lu, J.; E, L.; Roy, N.; Hutfles, L.; Burns, J. M.; et al, Human Molecular Genetics. 3931 - 3946. 19. 22. 2013. http://dx.doi.org/10.1093/hmg/ddt247 . 10.1093/hmg/ddt247 . Human Molecular Genetics

Multifunctional iron-chelators with protective roles against neurodegenerative diseases

Nunes, Andreia; Marques, Sérgio M.; Quintanova, Catarina; Silva, Diana F.; Cardoso, Sandra M.; Chaves, Sílvia; Santos, M. Amélia, Dalton Transactions. 17. 42. 2013. http://dx.doi.org/10.1039/c3dt50406a . 10.1039/c3dt50406a . Dalton Transactions

Prodromal Metabolic Phenotype in MCI Cybrids: Implications for Alzheimer’s Disease

F. Silva, D.; Santana, I.; R. Esteves, A.; Baldeiras, I.; M. Arduino, D.; R. Oliveira, C.; M. Cardoso, S., Current Alzheimer Research. 180 - 190. 2. 10. 2013. http://dx.doi.org/10.2174/1567205011310020008 . 10.2174/1567205011310020008 . Current Alzheimer Research

Mitochondrial metabolism in Parkinson's disease impairs quality control autophagy by hampering microtubule-dependent traffic

Arduíno, Daniela M.; Raquel Esteves, A.; Cortes, Luísa; Silva, Diana F.; Patel, Bindi; Grazina, Manuela; Swerdlow, Russell H.; Oliveira, Catarina R.; Cardoso, Sandra M., Human Molecular Genetics. 4680 - 4702. 21. 21. 2012. http://dx.doi.org/10.1093/hmg/dds309 . 10.1093/hmg/dds309 . Human Molecular Genetics

Therapeutic Intervention at Cellular Quality Control Systems in Alzheimers and Parkinsons Diseases

M. Arduino, Daniela; Raquel Esteves, A.; F.F. Silva, Diana; Martins-Branco, Diogo; Santos, Daniel; F. Gomes Pimentel, Diana; M. Cardoso, Sandra, Current Pharmaceutical Design. 3446 - 3459. 31. 17. 2011. http://dx.doi.org/10.2174/138161211798072481 . 10.2174/138161211798072481 . Current Pharmaceutical Design

Amyloid-ß-Induced Mitochondrial Dysfunction Impairs the Autophagic Lysosomal Pathway in a Tubulin Dependent Pathway

Silva, Diana F.F.; Esteves, A. Raquel; Arduino, Daniela M.; Oliveira, Catarina R.; Cardoso, Sandra M., Journal of Alzheimer's Disease. 565 - 581. 3. 26. 2011. http://dx.doi.org/10.3233/jad-2011-110423 . 10.3233/jad-2011-110423 . Journal of Alzheimer's Disease

Mitochondrial Dysfunction: The Road to Alpha-Synuclein Oligomerization in PD

Esteves, A. R.; Arduíno, D. M.; Silva, D. F. F.; Oliveira, C. R.; Cardoso, S. M., Parkinson's Disease. 1 - 20. 2011. 2011. http://dx.doi.org/10.4061/2011/693761 . 10.4061/2011/693761 . Parkinson's Disease

Mitochondria: The Common Upstream Driver of Amyloid-ß and Tau Pathology in Alzheimer's Disease

F.F. Silva, Diana; Raquel Esteves, A.; R. Oliveira, Catarina; M. Cardoso, Sandra, Current Alzheimer Research. 1 - 10. 999. 999. 2011. http://dx.doi.org/10.2174/1567211212443562050 . 10.2174/1567211212443562050 . Current Alzheimer Research

Cross-talk between mitochondria and proteasome in Parkinson’s disease pathogenesis

Branco, Diogo Martins, Frontiers in Aging Neuroscience. 2010. http://dx.doi.org/10.3389/fnagi.2010.00017 . 10.3389/fnagi.2010.00017 . Frontiers in Aging Neuroscience

All projects

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Information of exclusive responsibility of the researcher 21-11-2021 , from platform CIÊNCIAVITAE.

2021 - 2023

The Gut-Brain-Immune system axis in Parkinson´s disease.

PTDC/MED-NEU/3644/2020

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2019 - 2021

The role of quality control mechanisms in the loss of proteostasis in age-dependent neurodegenerative disorders

PTDC/MED-NEU/30712/2017

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2018 - 2021

The ups and downs of cellular stress: the "MAM hypothesis" for Bipolar disorder pathophysiology.

PTDC/MED-NEU/28214/2017

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2017 - 2020

The toxinogenic gut microbiome in sporadic Parkinson’s Disease: a quest for new “antiPDbiotics”.

Prémio Santa Casa Mantero Belard 2016

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Santa Casa da Misericórdia de Lisboa

2014 - 2014

Validate tau acetylation as an AD biomarker.

Project GAI

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Universidade de Coimbra Faculdade de Medicina

2010 - 2012

Mitochondrial-dependent impairment of intracellular trafficking in Parkinson’s disease

PTDC/SAU-NEU/102710/2008

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2010 - 2011

Early Diagnosis of Alzheimer’s Disease: evaluation of recent classification criteria and proposal of new diagnostic tools

PIC/IC/83206/2007

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular; Centro Hospitalar e Universitário de Coimbra EPE

Funders: Fundação para a Ciência e a Tecnologia

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