Neuroscience and Disease

Neuroendocronology and Aging

Aging

Hypothalamus

Biological Clocks

Autofagia

Inflammation


Research lines

Neuroendocrine axis and aging

Hypothalamus: a target to delay aging and age-related disorders

New drugs to target hallmarks of aging and age-related diseases

Circadian Rhythms in aging and age-related diseases

Overview

The Mission of Neuroendocrinology and Aging Group is to contribute to develop new knowledge in the aging field, namely to demonstrate that neuroendocrine system and related mechanisms can be targeted in experimental models to delay, stop, and in some examples, reverse manifestations of aging and age-related disorders.

The knowledge generated by our group has been contributing to the hypothesis that aging and age-related disorders could be controlled by using neuroendocrine strategies. These strategies are based on targeting the main brain area involved in the neuroendocrine system - the hypothalamus -, its main functions (circadian rhythm, sleep, food intake, metabolism), and also the hypothalamus-periphery axis.

Objectives

  • To investigate the neuroendocrine axis contribution to ageing and age-related disorders;
  • To investigate new strategies to delay aging and age-related disorders by targeting the hypothalamus or by targeting hypothalamic related mechanisms;
  • To use caloric restriction mimetic approaches, as neuropeptides, new sirtuins-1 activators, circadian rhythm reestablishment to prevent aging and age-related diseases or disabilities (metabolism dysfunction, osteoarthrite (OA), sleep dysfunctions, neurodegenerative diseases);
  • To understand if and how obstructive sleep apnea (OSA), insomnia or obesity induce or accelerate molecular mechanisms of ageing.

The group members have complementary expertise: establishment of cellular and animal models of aging and age-related disorders (progeria, neurodegenerative disorders, OSA, OA, insomnia, metabolic dysfunction and obesity), evaluation of physiology, cellular and molecular aging markers (namely autophagy, senescence, inflammation), gene transfer approaches, circadian rhythm analysis, medicinal chemistry and histopathological methodologies. Moreover, the group has expertise to organize pre-clinical studies and public engagement activities.

Publications

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Information about journal articles, updated at 05-12-2021, from platform CIÊNCIAVITAE.

Cellular senescence mechanisms in the context of current biomarkers and senotherapies

Vasco Lucas; Claudia Cavadas; Aveleira C, 2021. Aging Research Reviews. 2021. under revision Aging Research Reviews

PI3K/AKT/MTOR and ERK1/2/MAPK signaling pathways are involved in autophagy stimulation induced by caloric restriction or caloric restriction mimetics in cortical neurons.

Ferreira-Marques, Marisa (EA15-6C9F-F15E); Carvalho, A; Cavadas, Cláudia (D413-2E77-4BDE); Aveleira, Célia A (651B-75AE-BD02), 2021. Aging. 2021. accepted Aging

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Klionsky D J; Abdel-Aziz A K; ...; Aveleira C; Chun-Kit Tong, 2021. Autophagy. 2021. https://www.tandfonline.com/doi/full/10.1080/15548627.2020.1797280 . published Autophagy

Common risk factors and therapeutic targets in obstructive sleep apnea and osteoarthritis: An unexpectable link?

Gaspar, Laetitia S.; Sousa, Cátia; Álvaro, Ana Rita; Cavadas, Cláudia; Mendes, Alexandrina Ferreira, 2021. Pharmacological Research. 164. 2021. http://dx.doi.org/10.1016/j.phrs.2020.105369 . 10.1016/j.phrs.2020.105369 . Pharmacological Research

Long-term Continuous Positive Airway Pressure Treatment Ameliorates Biological Clock Disruptions in Obstructive Sleep Apnea

C014-4DE9-206C; Janina Hesse; Müge Yalçin; 0F1A-8AFD-63A0; Catarina Carvalhas-Almeida; Mafalda Ferreira; B01F-45DC-F6D7; et al, 2021. Ebiomedicine. 2021. in press Ebiomedicine

Common risk factors and therapeutic targets in obstructive sleep apnea and osteoarthritis: An unexpectable link?

Laetitia S. Gaspar; Cátia Sousa; Ana Rita Álvaro; Cláudia Cavadas; Alexandrina Ferreira Mendes, 2021. Pharmacological Research. 105369 - 105369. 2021. https://doi.org/10.1016/j.phrs.2020.105369 . 10.1016/j.phrs.2020.105369 . Pharmacological Research

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Mendes, Alexandrina Ferreira , 2021. Autophagy. 2021. https://www.tandfonline.com/doi/full/10.1080/15548627.2020.1797280 . 10.1080/15548627.2020.1797280 . published Autophagy

Elucidation of the Mechanism Underlying the Anti-Inflammatory Properties of (S)-(+)-Carvone Identifies a Novel Class of Sirtuin-1 Activators in a Murine Macrophage Cell Line

Cátia Sousa; Bruno Miguel Neves; Alcino Jorge Leitão; Alexandrina Ferreira Mendes, 2021. Biomedicines. 777 - 777. 7. 9. 2021. https://doi.org/10.3390/biomedicines9070777 . 10.3390/biomedicines9070777 . Biomedicines

Standardised comparison of limonene-derived monoterpenes identifies structural determinants of anti-inflammatory activity

Mendes, Alexandrina Ferreira , 2020. Scientific Reports. 10. 2020. https://rdcu.be/b3Rts . published Scientific Reports

The Superpowers of Our Sleep

Gaspar, Laetitia S.; Santos, Bárbara; Barros-Viegas, Ana Teresa; Cardoso, João; Varela Amaral, Sara; Carvalhas-Almeida, Catarina; Santos-Carvalho, Ana; Cavadas, Cláudia; Álvaro, Ana Rita, 2020. Frontiers for Young Minds. 8. 2020. http://dx.doi.org/10.3389/frym.2020.540052 . 10.3389/frym.2020.540052 . Frontiers for Young Minds

Expression and function of the nonclassical estrogen receptor, GPR30, in human cartilage and chondrocytes

Madalena Ribeiro; Cátia Sousa; Ana T. Rufino; Fernando Judas; Alexandrina F. Mendes, 2020. Journal of Cellular Physiology. 2020. https://doi.org/10.1002/jcp.29691 . 10.1002/jcp.29691 . Journal of Cellular Physiology

Neuropeptide Y Enhances Progerin Clearance and Ameliorates the Senescent Phenotype of Human Hutchinson-Gilford Progeria Syndrome Cells.

Aveleira, Célia A; Ferreira-Marques, Marisa; Cortes, Luísa; Valero, Jorge; Pereira, Dina; Pereira de Almeida, Luís; Cavadas, Cláudia, 2020. The Journals of Gerontology: Series A. 2020. http://dx.doi.org/10.1093/gerona/glz280 . 10.1093/gerona/glz280 . published The Journals of Gerontology: Series A

Dichotomous Sirtuins: Implications for Drug Discovery in Neurodegenerative and Cardiometabolic Diseases

Mendes, Alexandrina Ferreira , 2019. Trends in Pharmacological Sciences. 2019. http://dx.doi.org/10.1016/j.tips.2019.09.003 . 10.1016/j.tips.2019.09.003 . Trends in Pharmacological Sciences

The importance of determining circadian parameters in pharmacological studies

Mendes, Alexandrina, 2019. British Journal of Pharmacology. 2019. http://dx.doi.org/10.1111/bph.14712 . 10.1111/bph.14712 . British Journal of Pharmacology

The importance of determining circadian parameters in pharmacological studies

Laetitia S. Gaspar; Ana Rita Álvaro; Sara Carmo-Silva; Alexandrina Ferreira Mendes; Angela Relógio; Cláudia Cavadas, 2019. British Journal of Pharmacology. 2827 - 2847. 16. 176. 2019. https://doi.org/10.1111/bph.14712 . 10.1111/bph.14712 . British Journal of Pharmacology

The “Journal of Functional Morphology and Kinesiology” Journal Club Series: Highlights on Recent Papers in Exercise-Induced Immune Response

Mendes, Alexandrina, 2018. Journal of Functional Morphology and Kinesiology. 2018. http://www.mdpi.com/2411-5142/3/3/42 . 10.3390/jfmk3030042 . Journal of Functional Morphology and Kinesiology

Loss of hierarchical imprinting regulation at the Prader-Willi/Angelman syndrome locus in human iPSCs.

Pólvora-Brandão D; Joaquim M; Godinho I; Aprile D; Álvaro AR; Onofre I; Raposo AC; et al, 2018. Human molecular genetics. 2018. http://europepmc.org/abstract/med/30102380 . 10.1093/hmg/ddy274 . Human molecular genetics

Editorial: The Physiology of Inflammation—The Final Common Pathway to Disease

Mendes, Alexandrina, 2018. Frontiers in Physiology. 2018. 10.3389/fphys.2018.01741 . Frontiers in Physiology

Elevated Glucose and Interleukin-1ß Differentially Affect Retinal Microglial Cell Proliferation

Baptista, Filipa I.; Aveleira, Célia A.; Castilho, Áurea F.; Ambrósio, António F., 2017. Mediators of Inflammation. 1 - 11. 2017. 2017. http://dx.doi.org/10.1155/2017/4316316 . 10.1155/2017/4316316 . published Mediators of Inflammation

Obstructive Sleep Apnea and Hallmarks of Aging

Gaspar, L.S.; Álvaro, A.R.; Moita, J.; Cavadas, C., 2017. Trends in Molecular Medicine. 675 - 692. 8. 23. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85025131167&partnerID=MN8TOARS . 10.1016/j.molmed.2017.06.006 . Trends in Molecular Medicine

Hyperglycemia and Hyperinsulinemia-Like Conditions Independently Induce Inflammatory Responses in Human Chondrocytes

Rufino, Ana; Ribeiro, Madalena; Pinto Ferreira, João; Judas, Fernando; Mendes, Alexandrina, 2017. Journal of Functional Morphology and Kinesiology. 2. 2. 2017. http://dx.doi.org/10.3390/jfmk2020015 . 10.3390/jfmk2020015 . Journal of Functional Morphology and Kinesiology

The pathophysiology of defective proteostasis in the hypothalamus - from obesity to ageing

Cavadas, Cláudia; Aveleira, Célia A.; Souza, Gabriela F. P.; Velloso, Lício A., 2016. Nature Reviews Endocrinology. 723 - 733. 12. 12. 2016. http://dx.doi.org/10.1038/nrendo.2016.107 . 10.1038/nrendo.2016.107 . published Nature Reviews Endocrinology

The “Journal of Functional Morphology and Kinesiology” Journal Club Series: Highlights on Recent Papers in Articular Cartilage Tissue Engineering and Mechanical Stimulation

Mendes, Alexandrina, 2016. Journal of Functional Morphology and Kinesiology. 2016. http://www.mdpi.com/2411-5142/1/2/162 . 10.3390/jfmk1020162 . Journal of Functional Morphology and Kinesiology

Caloric restriction stimulates autophagy in rat cortical neurons through neuropeptide Y and ghrelin receptors activation

Ferreira-Marques, Marisa; Aveleira, Célia A.; Carmo-Silva, Sara; Botelho, Mariana; Pereira de Almeida, Luís; Cavadas, Cláudia, 2016. Aging. 1470 - 1484. 7. 8. 2016. http://dx.doi.org/10.18632/aging.100996 . 10.18632/aging.100996 . published Aging

Diabetes-accelerated experimental osteoarthritis is prevented by autophagy activation

Ribeiro, M.; López de Figueroa, P.; Nogueira-Recalde, U.; Centeno, A.; Mendes, A.F.; Blanco, F.J.; Caramés, B., 2016. Osteoarthritis and Cartilage. 2116 - 2125. 12. 24. 2016. http://dx.doi.org/10.1016/j.joca.2016.06.019 . 10.1016/j.joca.2016.06.019 . Osteoarthritis and Cartilage

Assessment of cell line competence for studies of pharmacological GPR30 modulation

Sousa, Cátia; Ribeiro, Madalena; Rufino, Ana Teresa; Leitão, Alcino Jorge; Mendes, Alexandrina Ferreira, 2016. Journal of Receptors and Signal Transduction. 181 - 188. 2. 37. 2016. http://dx.doi.org/10.1080/10799893.2016.1203943 . 10.1080/10799893.2016.1203943 . Journal of Receptors and Signal Transduction

Insulin decreases autophagy and leads to cartilage degradation

Ribeiro, M.; López de Figueroa, P.; Blanco, F.J.; Mendes, A.F.; Caramés, B., 2016. Osteoarthritis and Cartilage. 731 - 739. 4. 24. 2016. http://dx.doi.org/10.1016/j.joca.2015.10.017 . 10.1016/j.joca.2015.10.017 . Osteoarthritis and Cartilage

Copper induced apoptosis in Caco-2 and Hep-G2 cells: Expression of caspases 3, 8 and 9, AIF and p53

Santos, S.; Silva, A.M.; Matos, M.; Monteiro, S.M.; Álvaro, A.R., 2016. Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology. 138 - 146. 185-186. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84963665511&partnerID=MN8TOARS . 10.1016/j.cbpc.2016.03.010 . Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology

Evaluation of the anti-inflammatory, anti-catabolic and pro-anabolic effects of E-caryophyllene, myrcene and limonene in a cell model of osteoarthritis

Rufino, A.T.; Ribeiro, M.; Sousa, C.; Judas, F.; Salgueiro, L.; Cavaleiro, C.; Mendes, A.F., 2015. European Journal of Pharmacology. 141 - 150. 750. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84922572075&partnerID=MN8TOARS . 10.1016/j.ejphar.2015.01.018 . European Journal of Pharmacology

Impaired adrenal medullary function in a mouse model of depression induced by unpredictable chronic stress

Santana, M.M.; Rosmaninho-Salgado, J.; Cortez, V.; Pereira, F.C.; Kaster, M.P.; Aveleira, C.A.; Ferreira, M.; Álvaro, A.R.; Cavadas, C., 2015. European Neuropsychopharmacology. 1753 - 1766. 10. 25. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84943267584&partnerID=MN8TOARS . 10.1016/j.euroneuro.2015.06.013 . European Neuropsychopharmacology

Neuropeptide Y stimulates autophagy in hypothalamic neurons

Aveleira, Célia A.; Botelho, Mariana; Carmo-Silva, Sara; Pascoal, Jorge F.; Ferreira-Marques, Marisa; Nóbrega, Clévio; Cortes, Luísa; et al, 2015. Proceedings of the National Academy of Sciences. E1642 - E1651. 13. 112. 2015. http://dx.doi.org/10.1073/pnas.1416609112 . 10.1073/pnas.1416609112 . published Proceedings of the National Academy of Sciences

NPY/neuropeptide Y enhances autophagy in the hypothalamus: a mechanism to delay aging?

Aveleira, Célia A; Botelho, Mariana; Cavadas, Cláudia, 2015. Autophagy. 1431 - 1433. 8. 11. 2015. http://dx.doi.org/10.1080/15548627.2015.1062202 . 10.1080/15548627.2015.1062202 . Autophagy

Evaluation of the anti-inflammatory, anti-catabolic and pro-anabolic effects of E-caryophyllene, myrcene and limonene in a cell model of osteoarthritis

Mendes, Alexandrina, 2015. European Journal of Pharmacology. 2015. http://www.sciencedirect.com/science/article/pii/S0014299915000412 . http://dx.doi.org/10.1016/j.ejphar.2015.01.018 . European Journal of Pharmacology

Long-term exposure to high glucose increases the content of several exocytotic proteins and of vesicular GABA transporter in cultured retinal neural cells

Baptista, Filipa I.; Castilho, Áurea F.; Gaspar, Joana M.; Liberal, Joana T.; Aveleira, Célia A.; Ambrósio, António F., 2015. Neuroscience Letters. 56 - 61. 602. 2015. http://dx.doi.org/10.1016/j.neulet.2015.06.044 . 10.1016/j.neulet.2015.06.044 . published Neuroscience Letters

Impaired adrenal medullary function in a mouse model of depression induced by unpredictable chronic stress

Santana, Magda M.; Rosmaninho-Salgado, Joana; Cortez, Vera; Pereira, Frederico C.; Kaster, Manuella P.; Aveleira, Célia A.; Ferreira, Marisa; Álvaro, Ana Rita; Cavadas, Cláudia, 2015. European Neuropsychopharmacology. 1753 - 1766. 10. 25. 2015. http://dx.doi.org/10.1016/j.euroneuro.2015.06.013 . 10.1016/j.euroneuro.2015.06.013 . published European Neuropsychopharmacology

Neuropeptide Y stimulates autophagy in hypothalamic neurons

Aveleira, Célia A.; Botelho, Mariana; Carmo-Silva, Sara; Pascoal, Jorge F.; Ferreira-Marques, Marisa; Nóbrega, Clévio; Cortes, Luísa; et al, 2015. Proceedings of the National Academy of Sciences. E1642 - E1651. 13. 112. 2015. 10.1073/pnas.1416609112 . published Proceedings of the National Academy of Sciences

Tissue Engineered Cartilage in Unconfined Compression: Biomechanical Analysis

Cátia Bandeiras; António Completo; António Ramos; Ana Teresa Rufino; Madalena Ribeiro; João Pinto Ferreira; Alexandrina Ferreira Mendes, 2015. Materials Today: Proceedings. 355 - 364. 1. 2. 2015. https://doi.org/10.1016%2Fj.matpr.2015.04.032 . 10.1016/j.matpr.2015.04.032 . Materials Today: Proceedings

Differential effects of the essential oils of Lavandula luisieri and Eryngium duriaei subsp. juresianum in cell models of two chronic inflammatory diseases

Rufino, Ana T.; Ferreira, Isabel; Judas, Fernando; Salgueiro, Lígia; Lopes, M. Celeste; Cavaleiro, Carlos; Mendes, Alexandrina F., 2015. Pharmaceutical Biology. 1220 - 1230. 8. 53. 2015. http://dx.doi.org/10.3109/13880209.2014.970701 . 10.3109/13880209.2014.970701 . Pharmaceutical Biology

Diabetes-induced osteoarthritis: role of hyperglycemia in joint destruction

Alexandrina F Mendes; Susana C Rosa; Ana T Rufino; Madalena Ribeiro; Fernando Judas, 2015. BMC Musculoskeletal Disorders. S1. 16. 2015. https://doi.org/10.1186%2F1471-2474-16-s1-s1 . 10.1186/1471-2474-16-s1-s1 . BMC Musculoskeletal Disorders

Anti-inflammatory and Chondroprotective Activity of (+)-a-Pinene: Structural and Enantiomeric Selectivity

Mendes, Alexandrina, 2014. Journal of Natural Products. 2014. 10.1021/np400828x . Journal of Natural Products

Emerging novel roles of neuropeptide Y in the retina: From neuromodulation to neuroprotection

Santos-Carvalho, Ana; ¿?lvaro, Ana Rita; Martins, João; Ambrósio, António Francisco; Cavadas, Cláudia, 2014. Progress in Neurobiology. 70 - 79. Jan. 112. 2014. 10.1016/j.pneurobio.2013.10.002 . published Progress in Neurobiology

Fluoxetine induces proliferation and inhibits differentiation of hypothalamic neuroprogenitor cells in vitro

Sousa-Ferreira, L; Aveleira, C.; Botelho, M; Álvaro, Ana Rita Costa Silva; de Almeida, P.L.; Cavadas, C., 2014. PLoS One. eCollection2014 - eCollection2014. 3. 9. 2014. 10.1371/journal.pone.0088917 . published PLoS One

Alterations in phospholipidomic profile in the brain of mouse model of depression induced by chronic unpredictable stress

Faria, R.; Santana, M.M.; Aveleira, C.A.; Simões, C.; Maciel, E.; Melo, T.; Santinha, D.; et al, 2014. Neuroscience. 1 - 11. 273. 2014. http://dx.doi.org/10.1016/j.neuroscience.2014.04.042 . 10.1016/j.neuroscience.2014.04.042 . published Neuroscience

Fluoxetine Induces Proliferation and Inhibits Differentiation of Hypothalamic Neuroprogenitor Cells In Vitro

Sousa-Ferreira, Lígia; Aveleira, Célia; Botelho, Mariana; Álvaro, Ana Rita; Pereira de Almeida, Luís; Cavadas, Cláudia, 2014. PLoS ONE. 3. 9. 2014. http://dx.doi.org/10.1371/journal.pone.0088917 . 10.1371/journal.pone.0088917 . published PLoS ONE

Resveratrol Modulates Cytokine-Induced JAK/STAT Activation More Efficiently than 5-Aminosalicylic Acid: An In Vitro Approach

Mendes, Alexandrina, 2014. PlosOne. 2014. 10.1371/journal.pone.0109048 . PlosOne

Neuropeptide Y receptors activation protects rat retinal neural cells against necrotic and apoptotic cell death induced by glutamate

Santos-Carvalho, A; Elvas, F; ¿?lvaro, A R; Ambrósio, A F; Cavadas, C., 2013. Cell Death and Disease. e636 - e636. 5. 4. 2013. 10.1038/cddis.2013.160 . published Cell Death and Disease

Beclin 1 mitigates motor and neuropathological deficits in genetic mouse models of Machado–Joseph disease

Nascimento-Ferreira, Isabel; Nóbrega, Clévio; Vasconcelos-Ferreira, Ana; Onofre, Isabel; Albuquerque, David; Aveleira, Célia; Hirai, Hirokazu; Déglon, Nicole; Pereira de Almeida, Luís, 2013. Brain. 2173 - 2188. 7. 136. 2013. http://dx.doi.org/10.1093/brain/awt144 . 10.1093/brain/awt144 . published Brain

Neuropeptide Y Receptors Y1 and Y2 are Present in Neurons and Glial Cells in Rat Retinal Cells in Culture

Santos-Carvalho, Ana; Aveleira, Célia A.; Elvas, Filipe; Ambrósio, António Francisco; Cavadas, Cláudia, 2013. Investigative Opthalmology & Visual Science. 1. 54. 2013. http://dx.doi.org/10.1167/iovs.12-10776 . 10.1167/iovs.12-10776 . published Investigative Opthalmology & Visual Science

Expression and function of K(ATP) channels in normal and osteoarthritic human chondrocytes: Possible role in glucose sensing

Rufino, A.T.; Rosa, S.C.; Judas, F.; Mobasheri, A.; Lopes, M.C.; Mendes, A.F., 2013. Journal of Cellular Biochemistry. 1879 - 1889. 8. 114. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879133940&partnerID=MN8TOARS . 10.1002/jcb.24532 . Journal of Cellular Biochemistry

Physiology and pathophysiology of musculoskeletal aging: current research trends and future priorities

Mobasheri, Ali; Mendes, Alexandrina F., 2013. Frontiers in Physiology. 4. 2013. http://dx.doi.org/10.3389/fphys.2013.00073 . 10.3389/fphys.2013.00073 . Frontiers in Physiology

Physiology and pathophysiology of musculoskeletal aging: Current research trends and future priorities

Mobasheri, A.; Mendes, A.F., 2013. Frontiers in Physiology. 4 APR. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883809771&partnerID=MN8TOARS . 10.3389/fphys.2013.00073 . Frontiers in Physiology

Heme Oxygenase-1 Protects Retinal Endothelial Cells against High Glucose- and Oxidative/Nitrosative Stress-Induced Toxicity

Castilho, Áurea F.; Aveleira, Célia A.; Leal, Ermelindo C.; Simões, Núria F.; Fernandes, Carolina R.; Meirinhos, Rita I.; Baptista, Filipa I.; Ambrósio, António F., 2012. PLoS ONE. 8. 7. 2012. http://dx.doi.org/10.1371/journal.pone.0042428 . 10.1371/journal.pone.0042428 . published PLoS ONE

Potassium channels in articular chondrocytes

Mobasheri, A.; Lewis, R.; Ferreira-Mendes, A.; Rufino, A.; Dart, C.; Barrett-Jolley, R., 2012. Channels. 416 - 425. 6. 6. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84871438042&partnerID=MN8TOARS . 10.4161/chan.22340 . Channels

Moderate Long-Term modulation of Neuropeptide Y in hypothalamic arcuate nucleus induces energy balance alterations in adult rats

Sousa-Ferreira, L.; Garrido, M.; Nascimento-Ferreira, I.; Nobrega, C.; Santos-Carvalho, A.; Álvaro, A.R.; Rosmaninho-Salgado, J.; et al, 2011. PLoS ONE. 7. 6. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960672953&partnerID=MN8TOARS . 10.1371/journal.pone.0022333 . PLoS ONE

Proliferative Hypothalamic Neurospheres Express NPY, AGRP, POMC, CART and Orexin-A and Differentiate to Functional Neurons

Sousa-Ferreira, Lígia; ¿?lvaro, Ana Rita; Aveleira, Célia; Santana, Magda; Brandão, Inês; Kügler, Sebastian; Pereira de Almeida, Luís; Cavadas, Cláudia, 2011. PLoS ONE. 19745 - 19745. 5. 6. 2011. http://www.ncbi.nlm.nih.gov/pubmed/21589937 . 10.1371/journal.pone.0019745 . published PLoS ONE

Proliferative Hypothalamic Neurospheres Express NPY, AGRP, POMC, CART and Orexin-A and Differentiate to Functional Neurons

Sousa-Ferreira, Lígia; Álvaro, Ana Rita; Aveleira, Célia; Santana, Magda; Brandão, Inês; Kügler, Sebastian; Pereira de Almeida, Luís; Cavadas, Cláudia, 2011. PLoS ONE. 5. 6. 2011. http://dx.doi.org/10.1371/journal.pone.0019745 . 10.1371/journal.pone.0019745 . published PLoS ONE

Role of glucose as a modulator of anabolic and catabolic gene expression in normal and osteoarthritic human chondrocytes

Rosa, Susana C.; Rufino, Ana T.; Judas, Fernando M.; Tenreiro, Carlos; Lopes, M. Celeste; Mendes, Alexandrina Ferreira, 2011. Journal of Cellular Biochemistry. 2813 - 2824. 10. 112. 2011. 10.1002/jcb.23196 . published Journal of Cellular Biochemistry

Expression and function of the insulin receptor in normal and osteoarthritic human chondrocytes: modulation of anabolic gene expression, glucose transport and GLUT-1 content by insulin

Rosa, Susana C.; Rufino, Ana T.; Judas, Fernando M.; Tenreiro, Carlos; Lopes, M. Celeste; Mendes, Alexandrina Ferreira, 2011. Osteoarthritis and Cartilage. 719 - 727. 6. 19. 2011. 10.1016/j.joca.2011.02.004 . published Osteoarthritis and Cartilage

Cortical strut allografting in reconstructive orthopaedic surgery

Judas, F.; Saavedra, M.J.; Mendes, A.F.; Dias, R., 2011. Acta Reumatologica Portuguesa. 24 - 28. 1. 36. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955647442&partnerID=MN8TOARS . Acta Reumatologica Portuguesa

TNF-  Signals Through PKCz /NF- kB to Alter the Tight Junction Complex and Increase Retinal Endothelial Cell Permeability

Aveleira, C. A.; Lin, C.-M.; Abcouwer, S. F.; Ambrosio, A. F.; Antonetti, D. A., 2010. Diabetes. 2872 - 2882. 11. 59. 2010. http://dx.doi.org/10.2337/db09-1606 . 10.2337/db09-1606 . published Diabetes

Screening of Five Essential Oils for Identification of Potential Inhibitors of IL-1-induced Nf-¿B Activation and NO Production in Human Chondrocytes: Characterization of the Inhibitory Activity of a -Pinene

Neves, Ângela; Rosa, Susana C.; Gonçalves, Juliana; Rufino, Ana T.; Judas, Fernando M.; Salgueiro, Lígia; Lopes, M. Celeste; Cavaleiro, Carlos; Mendes, Alexandrina Ferreira, 2010. Planta Medica. 303 - 308. 03. 76. 2010. 10.1055/s-0029-1186085 . published Planta Medica

High glucose and interleukin-1ß downregulate interleukin-1 type I receptor (IL-1RI) in retinal endothelial cells by enhancing its degradation by a lysosome-dependent mechanism

Aveleira, Célia; Castilho, Áurea; Baptista, Filipa; Simões, Núria; Fernandes, Carolina; Leal, Ermelindo; Ambrósio, António Francisco, 2010. Cytokine. 279 - 286. 3. 49. 2010. http://dx.doi.org/10.1016/j.cyto.2009.11.014 . 10.1016/j.cyto.2009.11.014 . published Cytokine

Regulation of catecholamine release and tyrosine hydroxylase in human adrenal chromaffin cells by interleukin-1ß: Role of neuropeptide y and nitric oxide

Rosmaninho-Salgado, J.; Araújo, I.M.; ¿?lvaro, A.R.; Mendes, A.F.; Ferreira, L.; Grouzmann, E.; Mota, A.; et al, 2009. Journal of Neurochemistry. 911 - 922. 3. 109. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-64149092206&partnerID=MN8TOARS . 10.1111/j.1471-4159.2009.06023.x . published Journal of Neurochemistry

Neuropeptide Y inhibits [Ca 2+]i changes in rat retinal neurons through NPY Y1 , Y4 and Y5 receptors

Álvaro, Ana Rita ; Rosmaninho-Salgado, Joana; Ambrósio, António F.; Cavadas, Cláudia, 2009. Journal of Neurochemistry. 1508 - 1515. 5. 109. 2009. http://www.ncbi.nlm.nih.gov/pubmed/19344373 . 10.1111/j.1471-4159.2009.06079.x . published Journal of Neurochemistry

Assessment of strategies to increase chondrocyte viability in cryopreserved human osteochondral allografts: evaluation of the glycosylated hydroquinone, arbutin

Rosa, Susana C.; Gonçalves, Juliana; Judas, Fernando M.; Lopes, M. Celeste; Mendes, Alexandrina Ferreira, 2009. Osteoarthritis and Cartilage. 1657 - 1661. 12. 17. 2009. 10.1016/j.joca.2009.08.016 . published Osteoarthritis and Cartilage

Regulation of catecholamine release and tyrosine hydroxylase in human adrenal chromaffin cells by interleukin-1ß: role of neuropeptide Y and nitric oxide

Rosmaninho-Salgado, Joana; Araújo, Inês M.; ¿?lvaro, Ana Rita; Mendes, Alexandrina Ferreira; Ferreira, Lígia; Grouzmann, Eric; Mota, Alfredo; Duarte, Emília. P.; Cavadas, Cláudia, 2009. Journal of Neurochemistry. 911 - 922. 3. 109. 2009. 10.1111/j.1471-4159.2009.06023.x . published Journal of Neurochemistry

High glucose and oxidative/nitrosative stress conditions induce apoptosis in retinal endothelial cells by a caspase-independent pathway

Leal, Ermelindo C.; Aveleira, Célia A.; Castilho, Áurea F.; Serra, Andreia M.; Baptista, Filipa I.; Hosoya, Ken-Ichi; Forrester, John V.; Ambrósio, António F., 2009. Experimental Eye Research. 983 - 991. 5. 88. 2009. http://dx.doi.org/10.1016/j.exer.2008.12.010 . 10.1016/j.exer.2008.12.010 . published Experimental Eye Research

Impaired glucose transporter-1 degradation and increased glucose transport and oxidative stress in response to high glucose in chondrocytes from osteoarthritic versus normal human cartilage

Rosa, Susana C.; Gonçalves, Juliana; Judas, Fernando M.; Ali Mobasheri; Lopes, M. Celeste; Mendes, Alexandrina Ferreira, 2009. Arthritis Research & Therapy. 1 - 11. R80. 11. 2009. http://arthritis-research.com/content/11/3/R80 . 10.1186/ar2713 . published Arthritis Research & Therapy

Nitric oxide synthase isoforms and NF-¿B activity in normal and osteoarthritic human chondrocytes: Regulation by inducible nitric oxide

Rosa, Susana C.; Judas, Fernando M.; Lopes, M. Celeste; Mendes, Alexandrina Ferreira, 2008. Nitric Oxide. 276 - 283. 3. 19. 2008. 10.1016/j.niox.2008.07.005 . published Nitric Oxide

Neuropeptide Y stimulates retinal neural cell proliferation - involvement of nitric oxide

¿?lvaro, Ana Rita; Martins, João; Araújo, Inês M.; Rosmaninho-Salgado, Joana; Ambrósio, António F.; Cavadas, Cláudia, 2008. Journal of Neurochemistry. 2501 - 2510. 6. 105. 2008. http://www.ncbi.nlm.nih.gov/pubmed/18331583 . 10.1111/j.1471-4159.2008.05334.x . published Journal of Neurochemistry

Müller Cells Do Not Influence Leukocyte Adhesion to Retinal Endothelial Cells

Leal, Ermelindo C.; Aveleira, Célia A.; Castilho, Aurea F.; Baptista, Filipa I.; Ambrósio, António F., 2008. Ocular Immunology and Inflammation. 173 - 179. 4. 16. 2008. http://dx.doi.org/10.1080/09273940802204535 . 10.1080/09273940802204535 . published Ocular Immunology and Inflammation

Neuropeptide Y protects retinal neural cells against cell death induced by ecstasy

Álvaro, A. R.; Martins, J.; Costa, A.C.; Fernandes, E.; Carvalho, F.; Ambrósio, A.F.; Cavadas, C., 2008. Neuroscience. 97 - 105. 1. 152. 2008. http://www.ncbi.nlm.nih.gov/pubmed/18249070 . 10.1016/j.neuroscience.2007.12.027 . published Neuroscience

Facilitative glucose transporters in articular chondrocytes. Expression, distribution and functional regulation of GLUT isoforms by hypoxia, hypoxia mimetics, growth factors and pro-inflammatory cytokines.

Mobasheri, A.; Bondy, C.A.; Moley, K.; Mendes, A.F.; Rosa, S.C.; Richardson, S.M.; Hoyland, J.A.; Barrett-Jolley, R.; Shakibaei, M., 2008. Advances in anatomy, embryology, and cell biology. 200. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-58149170369&partnerID=MN8TOARS . Advances in anatomy, embryology, and cell biology

Chondrocyte Viability in Fresh and Frozen Large Human Osteochondral Allografts: Effect of Cryoprotective Agents

Judas, Fernando M.; Rosa, Susana C.; TEIXEIRA, L; Lopes, M. Celeste; Mendes, Alexandrina Ferreira, 2007. Transplantation Proceedings. 2531 - 2534. 8. 39. 2007. 10.1016/j.transproceed.2007.07.028 . published Transplantation Proceedings

NPY in rat retina is present in neurons, in endothelial cells and also in microglial and Müller cells

¿?lvaro, Ana Rita; Rosmaninho-Salgado, Joana; Santiago, Ana Raquel; Martins, João; Aveleira, Célia; Santos, Paulo F.; Pereira, Tiago; et al, 2007. Neurochemistry International. 757 - 763. 5. 50. 2007. http://www.ncbi.nlm.nih.gov/pubmed/17353067 . 10.1016/j.neuint.2007.01.010 . published Neurochemistry International

Neuropeptide Y regulates catecholamine release evoked by interleukin-1ß in mouse chromaffin cells

Rosmaninho-Salgado, Joana; ¿?lvaro, Ana Rita; Grouzmann, Eric; Duarte, Emilia P.; Cavadas, Cláudia, 2007. Peptides. 310 - 314. 2. 28. 2007. http://www.ncbi.nlm.nih.gov/pubmed/17207896 . 10.1016/j.peptides.2006.11.015 . published Peptides

Intracellular signaling mechanisms mediating catecholamine release upon activation of NPY Y1 receptors in mouse chromaffin cells

Rosmaninho-Salgado, J.; Araújo, I.M.; ¿?lvaro, A.R.; Duarte, E.P.; Cavadas, C.; Álvaro, A.R., 2007. Journal of Neurochemistry. 896 - 903. 3. 103. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-35248895279&partnerID=MN8TOARS . 10.1111/j.1471-4159.2007.04899.x . published Journal of Neurochemistry

Unaltered hepatic oxidative phosphorylation and mitochondrial permeability transition in wistar rats treated with nimesulide: Relevance for nimesulide toxicity characterization

Moreno, António J.; Oliveira, Paulo J.; Nova, Carlos D.; ¿?lvaro, Ana R.; Moreira, Renata A.; Santos, Sandra M. D.; Macedo, Tice, 2007. Journal of Biochemical and Molecular Toxicology. 53 - 61. 2. 21. 2007. http://www.ncbi.nlm.nih.gov/pubmed/17427176 . 10.1002/jbt.20159 . published Journal of Biochemical and Molecular Toxicology

NPY in rat retina is present in neurons, in endothelial cells and also in microglial and Müller cells

Álvaro, Ana Rita; Rosmaninho-Salgado, Joana; Santiago, Ana Raquel; Martins, João; Aveleira, Célia; Santos, Paulo F.; Pereira, Tiago; et al, 2007. Neurochemistry International. 757 - 763. 5. 50. 2007. http://dx.doi.org/10.1016/j.neuint.2007.01.010 . 10.1016/j.neuint.2007.01.010 . published Neurochemistry International

Dexamethasone prevents interleukin-1ß-induced nuclear factor-¿B activation by upregulating I¿B-a synthesis, in lymphoblastic cells

Castro-caldas, M.; Mendes, Alexandrina Ferreira; Carvalho, A. Pato; Duarte, C. B.; Lopes, M. Celeste, 2003. Mediators of Inflammation. 37 - 46. 1. 12. 2003. 10.1080/0962935031000096953 . published Mediators of Inflammation

Dexamethasone-induced and estradiol-induced CREB activation and annexin 1 expression in CCRF-CEM lymphoblastic cells: evidence for the involvement of cAMP and p38 MAPK

Castro-caldas, M.; Mendes, Alexandrina Ferreira; Duarte, C. B.; Lopes, M. Celeste, 2003. Mediators of Inflammation. 329 - 337. 6. 12. 2003. 10.1080/09629350310001633351 . published Mediators of Inflammation

Hydrogen peroxide mediates interleukin-1ß-induced AP-1 activation in articular chondrocytes: Implications for the regulation of iNOS expression

Mendes, Alexandrina Ferreira; Caramona, M. Margarida; Carvalho, A. Pato; Lopes, M. Celeste, 2003. Cell Biology and Toxicology. 203 - 214. 4. 19. 2003. 10.1023/B:CBTO.0000003730.21261.fa . published Cell Biology and Toxicology

Differential roles of hydrogen peroxide and superoxide in mediating IL-1-induced NF-kB activation and iNOS expression in bovine articular chondrocytes

Mendes, Alexandrina Ferreira; Caramona, M. Margarida; Carvalho, A. Pato; Lopes, M. Celeste, 2003. Journal of Cellular Biochemistry. 783 - 793. 4. 88. 2003. 10.1002/jcb.10428 . published Journal of Cellular Biochemistry

Diacerhein and Rhein Prevent Interleukin-1beta-Induced Nuclear Factor-kappaB Activation by Inhibiting the Degradation of Inhibitor kappaB-alpha

Mendes, Alexandrina Ferreira; Caramona, M. Margarida; Carvalho, A. Pato; Lopes, M. Celeste, 2002. Pharmacology and Toxicology. 22 - 28. 1. 91. 2002. 10.1034/j.1600-0773.2002.910104.x . published Pharmacology and Toxicology

Role of Mitogen-Activated Protein Kinases and Tyrosine Kinases on IL-1-Induced NF-¿B Activation and iNOS Expression in Bovine Articular Chondrocytes

Mendes, Alexandrina Ferreira; Caramona, M. Margarida; Carvalho, A. Pato; Lopes, M. Celeste, 2002. Nitric Oxide. 35 - 44. 1. 6. 2002. 10.1006/niox.2001.0378 . published Nitric Oxide

Role of nitric oxide in the activation of NF-kB, AP-1 and NOS II expression in articular chondrocytes

Mendes, Alexandrina Ferreira; Carvalho, A. Pato; Caramona, M. Margarida; Lopes, M. Celeste, 2002. Inflammation Research. 369 - 375. 7. 51. 2002. 10.1007/PL00000317 . published Inflammation Research

Role of nitric oxide in the activation of NF-¿B, AP-1 and NOS II expression in articular chondrocytes

Mendes, A.F.; Carvalho, A.P.; Caramona, M.M.; Lopes, M.C., 2002. Inflammation Research. 369 - 375. 7. 51. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036019462&partnerID=MN8TOARS . Inflammation Research

Diphenyleneiodonium inhibits NF-¿B activation and iNOS expression induced by IL-1ß: involvement of reactive oxygen species

Mendes, Alexandrina Ferreira; Carvalho, A. Pato; Caramona, M. Margarida; Lopes, M. Celeste, 2001. Mediators of Inflammation. 209 - 215. 4. 10. 2001. 10.1080/09629350120080401 . published Mediators of Inflammation

Changes in the subcellular distribution of the rat uterus oestrogen receptor as induced by oestradiol, tamoxifen and ZD 182, 780

Ferreira Mendes, A.; Caramona, M.M.; Celeste Lopes, M., 1996. Journal of Pharmacy and Pharmacology. 302 - 305. 3. 48. 1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029891372&partnerID=MN8TOARS . Journal of Pharmacy and Pharmacology

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