Ermelindo Carreira Leal

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Affiliation

Center for Neuroscience and Cell Biology, University of Coimbra

Publications

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Information about journal articles, updated at 28-11-2021, from platform CIÊNCIAVITAE.

Improved diabetic wound healing by bovine lactoferricin is associated with relevant changes in the skin immune response and microbiota

Mouritzen, Michelle V; Petkovic, Marija; Qvist, Katrine; Poulsen, Steen S; Alarico, Susana; Leal, Ermelindo C; Dalgaard, Louise T; et al, Molecular Therapy: Methods & Clinical Development. 2021. https://www.cell.com/molecular-therapy-family/methods/fulltext/S2329-0501(21)00023-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2329050121000231%3Fshowall%3Dtrue . https://doi.org/10.1016/j.omtm.2021.02.008 . in press Molecular Therapy: Methods & Clinical Development

Development of an optimized and scalable method for isolation of umbilical cord blood-derived small extracellular vesicles for future clinical use

Renato M. S. Cardoso; Silvia C. Rodrigues; Claudia F. Gomes; Filipe V. Duarte; Maryse Romao; Ermelindo C. Leal; Patricia C. Freire; Ricardo Neves; Joana Simões-Correia, STEM CELLS Translational Medicine. 2021. https://doi.org/10.1002/sctm.20-0376 . 10.1002/sctm.20-0376 . STEM CELLS Translational Medicine

Lack of lymphocytes impairs macrophage polarization and angiogenesis in diabetic wound healing.

Seraphim PM; Leal EC; Moura J; Gonçalves P; Gonçalves JP; Carvalho E, Life sciences. 2020. http://europepmc.org/abstract/med/32428597 . 10.1016/j.lfs.2020.117813 . Life sciences

Protein tyrosine phosphatase 1B inhibition as a potential therapeutic target for chronic wounds in diabetes.

Figueiredo A; Leal EC; Carvalho E, Pharmacological research. 2020. http://europepmc.org/abstract/med/32504834 . 10.1016/j.phrs.2020.104977 . Pharmacological research

Mechanistic Actions of microRNAs in Diabetic Wound Healing

Marija Petkovic; Anja Elaine Sørensen; Ermelindo Carreira Leal; Eugenia Carvalho; Louise Torp Dalgaard, Cells. 2228 - 2228. 10. 9. 2020. https://doi.org/10.3390/cells9102228 . 10.3390/cells9102228 . Cells

The Kinetics of Small Extracellular Vesicle Delivery Impacts Skin Tissue Regeneration

Henriques-Antunes, Helena; Cardoso, Renato M. S.; Zonari, Alessandra; Correia, Joana; Leal, Ermelindo C.; Jiménez-Balsa, Adrián; Lino, Miguel M.; et al, ACS Nano. 8694 - 8707. 8. 13. 2019. http://dx.doi.org/10.1021/acsnano.9b00376 . 10.1021/acsnano.9b00376 . ACS Nano

microRNA-155 inhibition restores Fibroblast Growth Factor 7 expression in diabetic skin and decreases wound inflammation. *Equal contribution

João Moura*; Anja Sørensen*; Leal, EC*; Rikke Svendsen; Lina Carvalho; Rie Juul Willemoes; Per Trolle Jørgensen; et al, Scientific Reports. 2019. https://doi.org/10.1038/s41598-019-42309-4 . 10.1038/s41598-019-42309-4 . Scientific Reports

Immune aging in diabetes and its implications in wound healing.

Moura, J; Madureira, P; Leal, E C; Fonseca, A C; Carvalho, E, Clinical immunology (Orlando, Fla.). 43 - 54. 200. 2019. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:30735729&KeyUID=MEDLINE:30735729 . 10.1016/j.clim.2019.02.002 . Clinical immunology (Orlando, Fla.)

Early skin aging in diabetes is associated with a decrease in CB1 cannabinoid receptor expression

Leal, E. C.; Pirzgalska, R.; Marques-da-Silva, D.; Moura, L.; Espinoza, D.; Ledent, C.; Kofalvi, A.; Carvalho, E., Diabetologia. S119 - S119. 60. 2017. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000408315001031&KeyUID=WOS:000408315001031 . Diabetologia

Regulation of miRNA-146a and miR-29a during wound healing in a mouse model of type 1 diabetes

Petkovic, M.; Sorensen, A. E.; Leal, E. C.; Moura, J.; Willemoes, R. J.; Jorgensen, P. T.; Wengel, J.; Carvalho, E.; Dalgaard, L. T., Diabetologia. S120 - S120. 60. 2017. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000408315001034&KeyUID=WOS:000408315001034 . Diabetologia

Calcium Dobesilate Is Protective against Inflammation and Oxidative/Nitrosative Stress in the Retina of a Type 1 Diabetic Rat Model

Voabil, P.; Liberal, J.; Leal, E.C.; Bauer, J.; Cunha-Vaz, J.; Santiago, A.R.; Ambrósio, A.F., Ophthalmic Research. 150 - 161. 3. 58. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85027095862&partnerID=MN8TOARS . 10.1159/000478784 . Ophthalmic Research

Mast cells regulate wound healing in diabetes

Tellechea, A.; Leal, E.C.; Kafanas, A.; Auster, M.E.; Kuchibhotla, S.; Ostrovsky, Y.; Tecilazich, F.; et al, Diabetes. 2006 - 2019. 7. 65. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84975889733&partnerID=MN8TOARS . 10.2337/db15-0340 . Diabetes

Diabetic wounds exhibit distinct microstructural and metabolic heterogeneity through label-free multiphoton microscopy

Quinn, K.P.; Leal, E.C.; Tellechea, A.; Kafanas, A.; Auster, M.E.; Veves, A.; Georgakoudi, I., Journal of Investigative Dermatology. 342 - 344. 1. 136. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84959460751&partnerID=MN8TOARS . 10.1038/JID.2015.371 . Journal of Investigative Dermatology

Three-dimensional human tissue models that incorporate diabetic foot ulcer-derived fibroblasts mimic in vivo features of chronic wounds

Maione, A.G.; Brudno, Y.; Stojadinovic, O.; Park, L.K.; Smith, A.; Tellechea, A.; Leal, E.C.; et al, Tissue Engineering - Part C: Methods. 499 - 508. 5. 21. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84928943198&partnerID=MN8TOARS . 10.1089/ten.tec.2014.0414 . Tissue Engineering - Part C: Methods

Substance P promotes wound healing in diabetes by modulating inflammation and macrophage phenotype

Leal, E.C.; Carvalho, E.; Tellechea, A.; Kafanas, A.; Tecilazich, F.; Kearney, C.; Kuchibhotla, S.; et al, American Journal of Pathology. 1638 - 1648. 6. 185. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84929889091&partnerID=MN8TOARS . 10.1016/j.ajpath.2015.02.011 . American Journal of Pathology

Alginate and DNA gels are suitable delivery systems for diabetic wound healing

Tellechea, A.; Silva, E.A.; Min, J.; Leal, E.C.; Auster, M.E.; Pradhan-Nabzdyk, L.; Shih, W.; Mooney, D.J.; Veves, A., International Journal of Lower Extremity Wounds. 146 - 153. 2. 14. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937551409&partnerID=MN8TOARS . 10.1177/1534734615580018 . International Journal of Lower Extremity Wounds

Mast Cell Stabilization: A Potential Treatment for Diabetic Wounds

Tellechea, Ana; Kafanas, Antonios; Leal, Ermelindo C.; Auster, Michael E.; Kuchibhotla, Sarada; Ostrovsky, Yana; Carvalho, Eugenia; Pradhan-Nabzdyk, Leena; Veves, Aristidis, Diabetes. A182 - A183. 64. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000359482700702&KeyUID=WOS:000359482700702 . Diabetes

SP regulates macrophage function in diabetic wound healing

Leal, E. C.; Tellechea, A.; Kuchibhotla, S.; Auster, M. E.; LoGerfo, F. W.; Pradhan-Nabzdyk, L.; Carvalho, E.; Veves, A., Diabetologia. S112 - S112. 57. 2014. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000344386100251&KeyUID=WOS:000344386100251 . Diabetologia

MAST CELL STABILIZATION: A POTENTIAL TREATMENT FOR DIABETIC FOOT ULCERS

Tellechea, A.; Kafanas, A.; Leal, E. C.; Auster, M. E.; Kuchibhotla, S.; Ostrovsky, Y.; Carvalho, E.; Pradhan-Nabzdyk, L.; Veves, A., Wound Repair and Regeneration. A62 - A62. 2. 22. 2014. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000332835400140&KeyUID=WOS:000332835400140 . Wound Repair and Regeneration

Neurotensin-loaded collagen dressings reduce inflammation and improve wound healing in diabetic mice

Moura, L.I.F.; Dias, A.M.A.; Suesca, E.; Casadiegos, S.; Leal, E.C.; Fontanilla, M.R.; Carvalho, L.; de Sousa, H.C.; Carvalho, E., Biochimica et Biophysica Acta - Molecular Basis of Disease. 32 - 43. 1. 1842. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887730276&partnerID=MN8TOARS . 10.1016/j.bbadis.2013.10.009 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Dipeptidyl peptidase-IV inhibition prevents blood-retinal barrier breakdown, inflammation and neuronal cell death in the retina of type 1 diabetic rats

Gonçalves, A.; Marques, C.; Leal, E.; Ribeiro, C.F.; Reis, F.; Ambrósio, A.F.; Fernandes, R., Biochimica et Biophysica Acta - Molecular Basis of Disease. 1454 - 1463. 9. 1842. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903487864&partnerID=MN8TOARS . 10.1016/j.bbadis.2014.04.013 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Impaired wound healing in diabetes through substance p dependent mechanism

Leal, E. C.; Carvalho, E.; Tellechea, A.; Kuchibhotla, S.; Auster, M.; LoGerfo, F. W.; Pradhan, L.; Veves, A., European Journal of Clinical Investigation. 99 - 99. 43. 2013. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000317141000286&KeyUID=WOS:000317141000286 . European Journal of Clinical Investigation

M1/M2 SKIN MACROPHAGE PHENOTYPE IS ALTERED IN DIABETES

Tellechea, A.; Leal, E. C.; Tecilazich, F.; Auster, M.; Nabzdyk, L. Pradhan; Veves, A., Wound Repair and Regeneration. A45 - A45. 2. 21. 2013. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000315914400127&KeyUID=WOS:000315914400127 . Wound Repair and Regeneration

Role of endothelial progenitor cells and inflammatory cytokines in healing of diabetic foot ulcers

Tecilazich, F.; Dinh, T.; Pradhan-Nabzdyk, L.; Leal, E.; Tellechea, A.; Kafanas, A.; Gnardellis, C.; et al, PLoS ONE. 12. 8. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84892726746&partnerID=MN8TOARS . 10.1371/journal.pone.0083314 . PLoS ONE

Increased skin inflammation and blood vessel density in human and experimental diabetes

Tellechea, A.; Kafanas, A.; Leal, E.C.; Tecilazich, F.; Kuchibhotla, S.; Auster, M.E.; Kontoes, I.; et al, International Journal of Lower Extremity Wounds. 4 - 11. 1. 12. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875254399&partnerID=MN8TOARS . 10.1177/1534734612474303 . International Journal of Lower Extremity Wounds

Chitosan-based dressings loaded with neurotensin-an efficient strategy to improve early diabetic wound healing

Moura, L.I.F.; Dias, A.M.A.; Leal, E.C.; Carvalho, L.; de Sousa, H.C.; Carvalho, E., Acta Biomaterialia. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886910358&partnerID=MN8TOARS . 10.1016/j.actbio.2013.09.040 . Acta Biomaterialia

Neurotensin Modulates the Migratory and Inflammatory Response of Macrophages under Hyperglycemic Conditions.

Carvalho E; Cruz MT; Leal EC; Moura LI; Silva L; Tellechea A, 2013. http://europepmc.org/abstract/med/24000330 . 10.1155/2013/941764 .

Protective effects of the dipeptidyl peptidase IV inhibitor sitagliptin in the blood-retinal barrier in a type 2 diabetes animal model

Gonçalves, A.; Leal, E.; Paiva, A.; Teixeira Lemos, E.; Teixeira, F.; Ribeiro, C.F.; Reis, F.; Ambrósio, A.F.; Fernandes, R., Diabetes, Obesity and Metabolism. 454 - 463. 5. 14. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859444000&partnerID=MN8TOARS . 10.1111/j.1463-1326.2011.01548.x . Diabetes, Obesity and Metabolism

Mechanisms Involved in the Development and Healing of Diabetic Foot Ulceration

Doupis, John; Giurini, John E.; Gnardellis, Charalambos; Kafanas, Antonios; Leal, Ermelindo; Lyons, Thomas E.; Pradhan, Leena; et al, Diabetes. 2937 - 2947. 11. 61. 2012. 10.2337/db09-1421 . Diabetes

Heme Oxygenase-1 Protects Retinal Endothelial Cells against High Glucose- and Oxidative/Nitrosative Stress-Induced Toxicity

Ambrosio, Antonio F.; Aveleira, Celia A.; Baptista, Filipa I.; Castilho, Aurea F.; Fernandes, Carolina R.; Leal, Ermelindo C.; Meirinhos, Rita I.; Simoes, Nuria F., Plos One. 8. 7. 2012. 10.1371/journal.pone.0042428 . Plos One

IMPAIRED WOUND HEALING IN DIABETES THROUGH SUBSTANCE P-DEPENDENT MECHANISM

Leal, E. C.; Carvalho, E.; Tellechea, A.; Kuchibhotla, S.; Auster, M.; LoGerfo, F. W.; Pradhan, L.; Veves, A., Wound Repair and Regeneration. A28 - A28. 2. 20. 2012. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000300943100065&KeyUID=WOS:000300943100065 . Wound Repair and Regeneration

MAST CELL DYSFUNCTION IMPAIRS WOUND HEALING IN DIABETES

Tellechea, A.; Leal, E. C.; Kafanas, A.; Kuchibhotla, S.; Auster, M.; Pradhan, L.; Carvalho, E.; Veves, A., Wound Repair and Regeneration. A42 - A42. 2. 20. 2012. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000300943100118&KeyUID=WOS:000300943100118 . Wound Repair and Regeneration

Diabetes impairs the expression of the CB1 cannabinoid receptor, the novel homeostatic regulator of the skin

Carvalho, E.; Espinoza, D.; Koefalvi, A.; Leal, E., Diabetologia. S458 - S458. 54. 2011. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000307671302326&KeyUID=WOS:000307671302326 . Diabetologia

Protein tyrosine phophatase 1B (PTP1B) deficiency promotes wound healing

Zabolotny, J. M.; Tellechea, A.; Leal, E.; Kontoes, I.; Kuchibhotla, S.; Pradhan, L.; Carvalho, E.; Veves, A., Diabetologia. S471 - S471. 54. 2011. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000307671302362&KeyUID=WOS:000307671302362 . Diabetologia

Neurotensin decreases TNF alpha-induced cell death in keratinocytes and macrophages: possible important role in diabetic wound healing

Carvalho, E.; Maio, V.; Leal, E., Diabetologia. S472 - S473. 54. 2011. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000307671302366&KeyUID=WOS:000307671302366 . Diabetologia

Neurotensin and chitosan-based dressings: a new approach for diabetic wound healing treatment

Moura, L.; Dias, A.; Leal, E.; Sousa, H.; Carvalho, E., Diabetologia. S472 - S472. 54. 2011. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000307671302365&KeyUID=WOS:000307671302365 . Diabetologia

Impaired mast cell function affects wound healing in diabetes

Tellechea, A.; Zabolotny, J. M.; Pradhan, L.; Leal, E.; Kafanas, A.; Kuchibhotla, S.; Carvalho, E.; Veves, A., Diabetologia. S471 - S471. 54. 2011. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000307671302361&KeyUID=WOS:000307671302361 . Diabetologia

Methamphetamine transiently increases the blood-brain barrier permeability in the hippocampus: Role of tight junction proteins and matrix metalloproteinase-9

Martins, T.; Baptista, S.; Gonçalves, J.; Leal, E.; Milhazes, N.; Borges, F.; Ribeiro, C.F.; et al, Brain Research. 28 - 40. 1411. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80052037570&partnerID=MN8TOARS . 10.1016/j.brainres.2011.07.013 . Brain Research

The Role of Neurotensin in Wound Healing in Diabetic and iNOS Knockout Mice

Leal, E; Tellechea, A; Moura, L; Veves, A; Carvalho, E, Diabetes. A269 - A269. 59. 2010. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000278844601309&KeyUID=WOS:000278844601309 . Diabetes

High glucose and interleukin-1 beta downregulate interleukin-1 type I receptor (IL-1RI) in retinal endothelial cells by enhancing its degradation by a lysosome-dependent mechanism

Ambrosio, AF; Aveleira, C; Baptista, F; Castilho, A; Fernandes, C; Leal, E; Simoes, N, Cytokine. 279 - 286. 3. 49. 2010. 10.1016/j.cyto.2009.11.014 . Cytokine

The Role of Mast Cells in Wound Healing in Diabetes

Carvalho, E; Leal, E; Tellechea, A; Pradhan, L; Kuchibhotla, S; Logerfo, FW; Veves, A, Diabetes. A327 - A327. 59. 2010. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000278844601526&KeyUID=WOS:000278844601526 . Diabetes

Angiogenic and Inflammatory Markers in Diabetic Wound Healing

Tellechea, A; Carvalho, E; Leal, E; Kuchibhotla, S; Pradhan, L; Logerfo, FW; Veves, A, Diabetes. A325 - A325. 59. 2010. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000278844601517&KeyUID=WOS:000278844601517 . Diabetes

High glucose and oxidative/nitrosative stress conditions induce apoptosis in retinal endothelial cells by a caspase-independent pathway

Leal, E.C.; Aveleira, C.A.; Castilho, A.F.; Serra, A.M.; Baptista, F.I.; Hosoya, K.-I.; Forrester, J.V.; Ambrósio, A.F., Experimental Eye Research. 983 - 991. 5. 88. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-64849101327&partnerID=MN8TOARS . 10.1016/j.exer.2008.12.010 . Experimental Eye Research

Muller cells do not influence leukocyte adhesion to retinal endothelial cells

Ambrosio, AF; Aveleira, CA; Baptista, FI; Castilho, AF; Leal, EC, Ocular Immunology and Inflammation. 173 - 179. 4. 16. 2008. 10.1080/09273940802204535 . Ocular Immunology and Inflammation

Inducible nitric oxide synthase isoform is a key mediator of leukostasis and blood-retinal barrier breakdown in diabetic retinopathy

Leal, E.C.; Manivannan, A.; Hosoya, K.-I.; Terasaki, T.; Cunha-Vaz, J.; Ambrósio, A.F.; Forrester, J.V., Investigative Ophthalmology and Visual Science. 5257 - 5265. 11. 48. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-38449108616&partnerID=MN8TOARS . 10.1167/iovs.07-0112 . Investigative Ophthalmology and Visual Science

Leukocyte adhesion and blood retinal barrier (BRB) breakdown in diabetic retinopathy (DR): Role of nitric oxide (NO)

Leal, EC; Manivannana, A; Aveleira, C; Serra, A; Castilho, A; Terasaki, T; Hosoya, KI; et al, Investigative Ophthalmology & Visual Science. 46. 2005. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000227980400417&KeyUID=WOS:000227980400417 . Investigative Ophthalmology & Visual Science

Old and new drug targets in diabetic retinopathy: From biochemical changes to inflammation and neurodegeneration

Leal, E.C.; Santiago, A.R.; Ambrósio, A.F., Current Drug Targets: CNS and Neurological Disorders. 421 - 434. 4. 4. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-23144443684&partnerID=MN8TOARS . 10.2174/1568007054546162 . Current Drug Targets: CNS and Neurological Disorders

Rat retinal endothelial cell dysfunction induced by hyperglycemia and oxidative stress: additive effects?

Leal, EC; Aveleira, C; Sa, M; Serra, A; Castilho, A; Terasaki, T; Hosoya, KI; Cunha-Vaz, J; Ambrosio, AF, Investigative Ophthalmology & Visual Science. U88 - U88. 45. 2004. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000223338200430&KeyUID=WOS:000223338200430 . Investigative Ophthalmology & Visual Science

Neurotoxicity induced by antiepileptic drugs in cultured hippocampal neurons: A comparative study between carbamazepine, oxcarbazepine, and two new putative antiepileptic drugs, BIA 2-024 and BIA 2-093

Araújo, I.M.; Ambrósio, A.F.; Leal, E.C.; Verdasca, M.J.; Malva, J.O.; Soares-Da-Silva, P.; Carvalho, A.P.; et al, Epilepsia. 1498 - 1505. 12. 45. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-10644282949&partnerID=MN8TOARS . 10.1111/j.0013-9580.2004.14104.x . Epilepsia

Early calpain-mediated proteolysis following AMPA receptor activation compromises neuronal survival in cultured hippocampal neurons

Araújo, I.M.; Verdasca, M.J.; Leal, E.C.; Bahr, B.A.; Ambrósio, A.F.; Carvalho, A.P.; Carvalho, C.M.; et al, Journal of Neurochemistry. 1322 - 1331. 6. 91. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-10644231739&partnerID=MN8TOARS . 10.1111/j.1471-4159.2004.02811.x . Journal of Neurochemistry

Neuronal nitric oxide synthase proteolysis limits the involvement of nitric oxide in kainate-induced neurotoxicity in hippocampal neurons

Araújo, I.M.; Ambrósio, A.F.; Leal, E.C.; Santos, P.F.; Carvalho, A.P.; Carvalho, C.M., Journal of Neurochemistry. 791 - 800. 3. 85. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-17944400535&partnerID=MN8TOARS . Journal of Neurochemistry

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Information of exclusive responsibility of the researcher 28-11-2021 , from platform CIÊNCIAVITAE.

2017/09/01 - 2020/03/31

Inhibition of macrophage protein tyrosine phosphatase 1B (PTP1B) as a novel therapy for improved wound healing in diabetes

Diabetes UK

Other

University of Aberdeen

Funders: Diabetes UK

2017/03 - 2019/02

Microcare - Microbiome of diabetic wounds: early diagnosis, prognosis and therapy

FIS-FIS-2015-01_DIA_20150630-144

Researcher

Center for Neuroscience and Cell Biology, University of Coimbra, Portugal

Funders: INFARMED - National Authority of Medicines and Health Products

2015/12/01 - 2017/12/31

Combination therapy synergistically accelerates diabetic wound closure

EFSD/Novartis Programme 2015

Researcher

Center for Neuroscience and Cell Biology, University of Coimbra, Portugal

Funders: European Association for the Study of Diabetes

2013/06/01 - 2016/11/30

Anticipating diabetes and diabetic wounding for siblings of Type 2 diabetics.

EXCL/DTP-PIC/0069/2012

Associacao Protectora dos Diabeticos de Portugal; Universidade Nova de Lisboa Faculdade de Ciências Médicas; Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2013/06 - 2016/05

Anticipating diabetes and diabetic wounding for siblings of Type 2 diabetics.

grant.Provided by PTCRIS: 124979

Invited Scientist Fellow

Funders: Stichting Weten

2012/04/01 - 2014/09/30

Neuropeptide release in wounds: a new therapeutic approach for the treatment of diabetic foot ulceration

PTDC/SAU-FAR/121109/2010

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2012/09/01 - 2015/12/31

Promoting endothelial progenitor cell function in diabetic wound healing

EFSD/JDRF/Novo Nordisk European Programme in Type 1 Diabetes Research

Principal investigator

Center for Neuroscience and Cell Biology, University of Coimbra, Portugal

Funders: European Association for the Study of Diabetes

2012/04 - 2014/09

Neuropeptide release in wounds: a new therapeutic approach for the treatment of diabetic foot ulceration

grant.Provided by PTCRIS: 121109

Principal investigator

Center for Neuroscience and Cell Biology, University of Coimbra, Portugal

Funders: Fundação para a Ciência e a Tecnologia

2012/09/01 - 2015/12/31

Promoting endothelial progenitor cell function in diabetic wound healing

EFSD/JDRF/Novo Nordisk European Programme in Type 1 Diabetes Research

Principal investigator

Center for Neuroscience and Cell Biology, University of Coimbra, Portugal

Funders: European Association for the Study of Diabetes

2011/03/01 - 2012/02/29

Characterization of the endothelial dysfunction in the retina of animal models of type 1 diabetes: potential therapeutic effects of sitagliptin

GIFT/SPD/2011

Invited Scientist Fellow

Funders: Sociedade Portuguesa de Diabetologia

2011/09/30 - 2013/03

Mechanisms of Neuropeptides Action in Diabetes

info:eu-repo/grantAgreement/NIH/NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES/1R01DK091949-01A1/US

Funders: National Institutes of Health

2011/09/01 - 2012/12/31

Sitagliptin as a potential therapeutic option for the treatment of diabetic retinopathy: novel insights into the mechanisms of action

EFSD/JDRF/GlaxoSmithKline

Invited Scientist Fellow

Center of Ophthalmology, IBILI, Faculty of Medicine, University of Coimbra, Portugal

Funders: European Association for the Study of Diabetes

2010/05/01 - 2013/10/31

Dissecting the molecular mechanisms of wound healing in diabetes - the role of neuropeptides

PTDC/SAU-MII/098567/2008

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2010/06/01 - 2013/03/01

Role of Neuropeptides in Diabetic Foot Problems

info:eu-repo/grantAgreement/NIH/NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE/5R01NS066205-02/US

Post-doc Fellow

Beth Isrel Deaconess Medical Center, Havard Medical School

Funders: National Institutes of Health

2010/05 - 2013/10

Dissecting the molecular mechanisms of wound healing in diabetes - the role of neuropeptides

grant.Provided by PTCRIS: 98567

Post-doc Fellow

Center for Neurocience and Cell Biology

Funders: Fundação para a Ciência e a Tecnologia

2010/04 - 2013/09

Impact of methamphetamine on the blood-brain barrier: unmasking the underlying mechanisms and the role of neuroinflammation

grant.Provided by PTCRIS: 98685

Invited Scientist Fellow

Faculty of Mecidine, University of Coimbra

Funders: Fundação para a Ciência e a Tecnologia

2009/01/01 - 2013/12/31

DISSECTING THE MECHANISMS OF NEURONAL DYSFUNCTION IN IMPAIRED WOUND HEALING IN DIABETES

SFRH/BPD/46341/2008

Funders: Fundação para a Ciência e a Tecnologia

2008/01/01 - 2008/08/31

Evaluation of the efficacy of a new formula on the prevention of cataract formation in a diabetic rat model

Oystershell, Belgium

Invited Scientist Fellow

Center of Ophthalmology, IBILI, Faculty of Medicine, University of Coimbra, Portugal

Funders: Oystershell

2008/09/01 - 2008/12/31

Nanomedicine and new terapeutic strategies: development of supramolecular structures to the treatment of ophthalmologic diseases

iCentro/NNTS/2008/01

Research Fellow

Center of Ophthalmology, IBILI, Faculty of Medicine, University of Coimbra, Portugal

2008/01/01 - 2008/08/31

Evaluation of the potential protective effect of calcium dobesilate against inflammation and oxidative/nitrosative stress in the retina of a diabetic rat model

PHARMA PROJECT: DX 2008/01

Researcher

Center of Ophthalmology, IBILI, Faculty of Medicine, University of Coimbra, Portugal

2007/06 - 2010/12

Regulation of AMPA receptors by hyperglycemia in the retina

grant.Provided by PTCRIS: 71228

PhD Student Fellow

Funders: Fundação para a Ciência e a Tecnologia

2007/06/01 - 2010/12/31

Regulation of AMPA receptors by hyperglycemia in the retina

PTDC/SAU-NEU/71228/2006

Universidade de Coimbra; Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2005/01/01 - 2005/12/31

Regulation of the expression of the type 1 IL-1 receptor in the retina

GAI 10/05

PhD Student Fellow

Faculty of Mecidine, University of Coimbra

Funders: Faculty of Mecidine, University of Coimbra

2002/10 - 2005/12

Mechanisms of cell degeneration in diabetic retinopathy

grant.Provided by PTCRIS: 38545

PhD Student Fellow

Funders: Fundação para a Ciência e a Tecnologia

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