Metabolism, Aging and Disease

Cell Signaling and Metabolism in Disease

Metabolism

Inflammation

Mitochondria

Endoplasmic Reticulum

Disease


Research lines

Metabolism, Mitochondria and Hormones in Brain Disorders

Mitochondrial Signaling in Neurodegeneration (mitSiN)

Endoplasmic Reticulum (ER) Stress Response and ER-Mitochondria Axis

β-Secretase-related Cellular Signaling and Therapeutics in Aging Disorders

Innate immunity in inflammation-related diseases

Overview

Our mission is to investigate cellular and molecular mechanisms with potential applications in the diagnosis, prognosis and targeted therapy for metabolic, inflammatory and brain disorders, using both in vitro and in vivo experimental models and also human samples. Major research lines aim to:

  • Elucidate the role of 1) mitochondria and metabolic hormones-mediated signaling pathways in brain changes associated to neurodegenerative and metabolic disorders and 2) hypoxia and reproductive senescence in neurodegenerative events;
  • Understand mitochondrial signaling role in disease, namely: 1) how mitochondrial DAMPs, which trigger sterile pro-inflammatory immune responses, could drive neurodegeneration; 2) how patients gut, blood or brain microbiota could activate neuronal innate immunity through mitochondrial dysfunction; c) whether new therapeutic strategies to avoid mild chronic inflammation can prevent protein oligomers formation and mitochondrial damage;
  • Clarify the biological basis of impaired cellular resilience in neuropsychiatric diseases, focusing how disturbances of ER-mitochondria axis trigger pathological deregulation of stress responses, metabolism and innate immunity, as well as to explore the therapeutic potential of Portuguese natural resources;
    Investigate the mechanisms of pathological programmed cell death, such as regulated necrosis, explore alterations in cellular trafficking that may impact disease progression and develop new BACE1 inhibitors acting as selective multifaceted disease-modifying drugs, preventing brain and peripheral changes;
  • Identify molecular mechanisms involved in peripheral and central inflammation with a special focus on macrophages and dendritic cells and design methodologies to evaluate whether natural/industrial chemicals modulate innate immunity to develop efficient laboratory tests for screening new drugs or potentially immunotoxic chemicals.

Publications

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Information about journal articles, updated at 05-12-2021, from platform CIÊNCIAVITAE.

Structural and Functional Alterations in Mitochondria-Associated Membranes (MAMs) and in Mitochondria Activate Stress Response Mechanisms in an In Vitro Model of Alzheimer's Disease

Tânia Fernandes; Rosa Resende; Diana F. Silva; Ana P. Marques; Armanda E. Santos; Sandra M. Cardoso; M. Rosário Domingues; Paula I. Moreira; Cláudia F. Pereira, 2021. Biomedicines. 881 - 881. 8. 9. 2021. https://doi.org/10.3390/biomedicines9080881 . 10.3390/biomedicines9080881 . Biomedicines

IGF1R Deficiency Modulates Brain Signaling Pathways and Disturbs Mitochondria and Redox Homeostasis

Susana Cardoso; Icíar López; Sergio Piñeiro-Hermida; José Pichel; Paula Moreira, 2021. Biomedicines. 158 - 158. 2. 9. 2021. https://doi.org/10.3390/biomedicines9020158 . 10.3390/biomedicines9020158 . Biomedicines

Intermittent Hypoxic Conditioning Rescues Cognition and Mitochondrial Bioenergetic Profile in the Triple Transgenic Mouse Model of Alzheimer's Disease

Sónia C. Correia; Nuno J. Machado; Marco G. Alves; Pedro F. Oliveira; Paula I. Moreira, 2021. International Journal of Molecular Sciences. 461 - 461. 1. 22. 2021. https://doi.org/10.3390/ijms22010461 . 10.3390/ijms22010461 . International Journal of Molecular Sciences

Mitochondrial Alterations in Fibroblasts of Early Stage Bipolar Disorder Patients

Ana P. Marques; Rosa Resende; Diana F. Silva; Mariana Batista; Daniela Pereira; Brigite Wildenberg; Sofia Morais; et al, 2021. Biomedicines. 2021. https://www.mdpi.com/2227-9059/9/5/522 . 10.3390/biomedicines9050522 . Biomedicines

Structural and Functional Alterations in Mitochondria-Associated Membranes (MAMs) and in Mitochondria Activate Stress Response Mechanisms in an In Vitro Model of Alzheimer’s Disease

Tânia Fernandes; Rosa Resende; Diana F. Silva; Ana P. Marques; Armanda E. Santos; Sandra M. Cardoso; M. Rosário Domingues; Paula I. Moreira; Cláudia F. Pereira, 2021. Biomedicines. 881 - 881. 8. 9. 2021. https://doi.org/10.3390/biomedicines9080881 . 10.3390/biomedicines9080881 . Biomedicines

Therapies for Alzheimer’s disease: a metabolic perspective

Domingues, Raquel; Pereira, Claúdia; Cruz, Maria Teresa; Silva, Ana, 2021. Molecular Genetics and Metabolism. 21. S1096-71. 2021. http://dx.doi.org/10.1016/j.ymgme.2021.01.011 . 10.1016/j.ymgme.2021.01.011 . published Molecular Genetics and Metabolism

Inflammation in Bipolar Disorder (BD): Identification of new therapeutic targets

Pereira, Ana Catarina; Oliveira, Joana; Silva, Sónia; Madeira, Nuno; Pereira, Cláudia M.F.; Cruz, Maria T., 2021. Pharmacological Research. 163. 2021. http://dx.doi.org/10.1016/j.phrs.2020.105325 . 10.1016/j.phrs.2020.105325 . published Pharmacological Research

Antitumor Activity of Fucus vesiculosus-Derived Phlorotannins through Activation of Apoptotic Signals in Gastric and Colorectal Tumor Cell Lines

Marcelo D. Catarino; Iva Fernandes; Hélder Oliveira; Mylene Carrascal; Rita Ferreira; Artur M. S. Silva; Maria Teresa Cruz; Nuno Mateus; Susana M. Cardoso, 2021. International Journal of Molecular Sciences. 7604 - 7604. 14. 22. 2021. https://doi.org/10.3390/ijms22147604 . 10.3390/ijms22147604 . International Journal of Molecular Sciences

Antifungal and Anti-Inflammatory Potential of Bupleurum rigidum subsp. paniculatum (Brot.) H.Wolff Essential Oil

Mónica Zuzarte; Pedro M. P. Correia; Jorge M. Alves-Silva; Maria J. Gonçalves; Carlos Cavaleiro; Teresa Cruz; Lígia Salgueiro, 2021. Antibiotics. 592 - 592. 5. 10. 2021. https://doi.org/10.3390/antibiotics10050592 . 10.3390/antibiotics10050592 . Antibiotics

WWOX: A New Therapeutic Target In Type 2 Diabetes-Associated Neurodegeneration

Carvalho, Cristina; Moreira, Paula I., 2021. Metabolism. 116. 2021. http://dx.doi.org/10.1016/j.metabol.2020.154616 . 10.1016/j.metabol.2020.154616 . Metabolism

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Pereira, Cláudia, 2021. Autophagy. 1 - 382. 8. 2021. published Autophagy

Anti-Inflammatory Activity of Calendula officinalis L. Flower Extract

Diva Silva; Marta Salvador Ferreira; José Manuel Sousa-Lobo; Maria Teresa Cruz; Isabel Filipa Almeida, 2021. Cosmetics. 2021. https://doi.org/10.3390/cosmetics8020031 . 10.3390/cosmetics8020031 . Cosmetics

Role of Coffee Caffeine and Chlorogenic Acids Adsorption to Polysaccharides with Impact on Brew Immunomodulation Effects

Cláudia P. Passos; Rita M. Costa; Sónia S. Ferreira; Guido R. Lopes; Maria T. Cruz; Manuel A. Coimbra, 2021. Foods. 2021. https://doi.org/10.3390/foods10020378 . 10.3390/foods10020378 . Foods

Oxygen Sensing and Signaling in Alzheimer's Disease: A Breathtaking Story!

Sónia C. Correia; Paula I. Moreira, 2021. Cellular and Molecular Neurobiology. 2021. https://doi.org/10.1007/s10571-021-01148-6 . 10.1007/s10571-021-01148-6 . Cellular and Molecular Neurobiology

Longitudinal normative OCT retinal thickness data for wild-type mice, and characterization of changes in the 3×Tg-AD mice model of Alzheimer's disease

Ferreira, Hugo; Martins, João; Moreira, Paula I.; Ambrósio, António Francisco; Castelo-Branco, Miguel; Serranho, Pedro; Bernardes, Rui, 2021. Aging. 2021. http://dx.doi.org/10.18632/aging.202916 . 10.18632/aging.202916 . Aging

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

Klionsky, Daniel J.; Abdel-Aziz, Amal Kamal; Abdelfatah, Sara; Abdellatif, Mahmoud; Abdoli, Asghar; Abel, Steffen; Abeliovich, Hagai; et al, 2021. Autophagy. 1 - 382. 1. 17. 2021. http://dx.doi.org/10.1080/15548627.2020.1797280 . 10.1080/15548627.2020.1797280 . Autophagy

Retina and Brain Display Early and Differential Molecular and Cellular Changes in the 3xTg-AD Mouse Model of Alzheimer's Disease

Rodrigues-Neves, Ana Catarina; Carecho, Rafael; Correia, Sónia Catarina; Carvalho, Cristina; Campos, Elisa Julião; Baptista, Filipa Isabel; Moreira, Paula Isabel; Ambrósio, António Francisco, 2021. Molecular Neurobiology. 2021. http://dx.doi.org/10.1007/s12035-021-02316-x . 10.1007/s12035-021-02316-x . Molecular Neurobiology

In vitro evaluation of potential benefits of a silica-rich thermal water (Monfortinho Thermal Water) in hyperkeratotic skin conditions

Ana Sofia Oliveira; Cátia Vicente Vaz; Ana Silva; Sara Correia; Raquel Ferreira; Luiza Breitenfeld; José Martinez-de-Oliveira; et al, 2020. International Journal of Biometeorology. 2020. https://doi.org/10.1007/s00484-020-01986-x . 10.1007/s00484-020-01986-x . International Journal of Biometeorology

Characterization and Cytotoxicity Assessment of the Lipophilic Fractions of Different Morphological Parts of Acacia dealbata

Cátia S. D. Oliveira; Patrícia Moreira; Judite Resende; Maria T. Cruz; Cláudia M. F. Pereira; Artur M. S. Silva; Sónia A. O. Santos; Armando J. D. Silvestre, 2020. International Journal of Molecular Sciences. 1814 - 1830. 5. 21. 2020. https://doi.org/10.3390/ijms21051814 . 10.3390/ijms21051814 . International Journal of Molecular Sciences

Pharmacological combination of nivolumab with dendritic cell vaccines in cancer immunotherapy: An overview

Calmeiro, Joao; Carrascal, Mylene A; Tavares, Adriana Ramos; Ferreira, Daniel Alexandre; Gomes, Celia; Cruz, Maria Teresa; Falcao, Amilcar; Neves, Bruno Miguel, 2020. Pharmacological Research. 2020. https://publons.com/publon/35514087/ . 10.1016/J.PHRS.2020.105309 . Pharmacological Research

Mitochondria, endoplasmic reticulum and innate immune dysfunction in mood disorders: Do Mitochondria-Associated Membranes (MAMs) play a role?

R. Resende; T. Fernandes; A.C. Pereira; J. De Pascale; A.P. Marques; P. Oliveira; S. Morais; et al, 2020. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 165752 - 165752. 6. 1866. 2020. https://doi.org/10.1016/j.bbadis.2020.165752 . 10.1016/j.bbadis.2020.165752 . published Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Chemical composition of Crithmum maritimum L. essential oil and hydrodistillation residual water by GC-MS and HPLC-DAD-MS/MS, and their biological activities

Jorge M. Alves-Silva; Inês Guerra; Maria José Gonçalves; Carlos Cavaleiro; Maria Teresa Cruz; Artur Figueirinha; Lígia Salgueiro, 2020. Industrial Crops and Products. 112329 - 112329. 149. 2020. https://doi.org/10.1016/j.indcrop.2020.112329 . 10.1016/j.indcrop.2020.112329 . Industrial Crops and Products

Dendritic Cell Vaccines for Cancer Immunotherapy: The Role of Human Conventional Type 1 Dendritic Cells

Calmeiro, João; Carrascal, Mylène A.; Tavares, Adriana Ramos; Ferreira, Daniel Alexandre; Gomes, Célia; Falcão, Amílcar; Cruz, Maria Teresa; et al, 2020. Pharmaceutics. 2. 12. 2020. http://dx.doi.org/10.3390/pharmaceutics12020158 . 10.3390/pharmaceutics12020158 . Pharmaceutics

Combining Virtual Screening Protocol and In Vitro Evaluation towards the Discovery of BACE1 Inhibitors

Coimbra, Judite R. M.; Baptista, Salete J.; Dinis, Teresa C. P.; Silva, Maria M. C.; Moreira, Paula I.; Santos, Armanda E.; Salvador, Jorge A. R., 2020. Biomolecules. 4. 10. 2020. http://dx.doi.org/10.3390/biom10040535 . 10.3390/biom10040535 . Biomolecules

Allergic contact dermatitis: From pathophysiology to development of new preventive strategies

Gonçalo Sousa Brites; Isabel Ferreira; Ana Isabel Sebastião; Ana Silva; Mylene Carrascal; Bruno Miguel Neves; Maria T. Cruz, 2020. Pharmacological Research. 105282 - 105282. 2020. https://doi.org/10.1016/j.phrs.2020.105282 . 10.1016/j.phrs.2020.105282 . Pharmacological Research

Mitochondria, endoplasmic reticulum and innate immune dysfunction in mood disorders: Do Mitochondria-Associated Membranes (MAMs) play a role?

Resende, R.; Fernandes, T.; Pereira, A.C.; De Pascale, J.; Marques, A.P.; Oliveira, P.; Morais, S.; et al, 2020. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 6. 1866. 2020. http://dx.doi.org/10.1016/j.bbadis.2020.165752 . 10.1016/j.bbadis.2020.165752 . Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Calcium Modulation, Anti-Oxidant and Anti-Inflammatory Effect of Skin Allergens Targeting the Nrf2 Signaling Pathway in Alzheimer’s Disease Cellular Models

Ana Silva; Marta Pereira; Mylène Carrascal; Brites, G; Neves BM; Patrícia Moreira; Rosa Resende; et al, 2020. International Journal of Molecular Sciences. 2020. https://www.mdpi.com/1422-0067/21/20/7791 . 10.3390/ijms21207791 . International Journal of Molecular Sciences

Characterization and Cytotoxicity Assessment of the Lipophilic Fractions of Different Morphological Parts of Acacia dealbata

Oliveira, Catia S. D.; Moreira, Patricia; Resende, Judite; Cruz, Maria T.; Pereira, Claudia M. F.; Silva, Artur M. S.; Santos, Sonia A. O.; Silvestre, Armando J. D., 2020. International Journal of Molecular Sciences. 2020. https://publons.com/publon/32969534/ . 10.3390/IJMS21051814 . International Journal of Molecular Sciences

Giardia lamblia Decreases NF-kappa B p65(RelA) Protein Levels and Modulates LPS-Induced Pro-Inflammatory Response in Macrophages

Faria, Clarissa Perez; Neves, Bruno Miguel; Lourenco, Agata; Cruz, Maria Teresa; Martins, Joao D.; Silva, Ana; Pereira, Sonia; Sousa, Maria do Ceu, 2020. Scientific Reports. 2020. https://publons.com/publon/932727/ . 10.1038/S41598-020-63231-0 . Scientific Reports

Inflammation in Bipolar Disorder (BD): Identification of New Therapeutic Targets

Ana Catarina Pereira; Joana Oliveira; Sónia Silva; Nuno Madeira; Cláudia MF Pereira; Maria T Cruz; Oliveira, Joana; et al, 2020. Pharmacological Research. 2020. https://publons.com/publon/34012396/ . 10.1016/J.PHRS.2020.105325 . Pharmacological Research

Crepis vesicaria L. subsp. taraxacifolia Leaves: Nutritional Profile, Phenolic Composition and Biological Properties

Sónia Pedreiro; Sandrine da Ressurreição; Maria Lopes; Maria Teresa Cruz; Teresa Batista; Artur Figueirinha; Fernando Ramos, 2020. International Journal of Environmental Research and Public Health. 2020. https://doi.org/10.3390/ijerph18010151 . 10.3390/ijerph18010151 . International Journal of Environmental Research and Public Health

In vitro evaluation of potential benefits of a silica-rich thermal water (Monfortinho Thermal Water) in hyperkeratotic skin conditions

Ana Sofia Oliveira; Cátia Vicente Vaz; Ana Silva; Sara Correia; Raquel Ferreira; Luiza Breitenfeld; José Martinez-de-Oliveira; et al, 2020. International Journal of Biometeorology. 2020. https://doi.org/10.1007/s00484-020-01986-x . 10.1007/s00484-020-01986-x . International Journal of Biometeorology

Calcium Signaling in Aging and Neurodegenerative Diseases 2019

Luísa Cortes; João Malva; Ana Cristina Rego; Cláudia F. Pereira, 2020. International Journal of Molecular Sciences. 1125 - 1125. 3. 21. 2020. https://doi.org/10.3390/ijms21031125 . 10.3390/ijms21031125 . International Journal of Molecular Sciences

Phlorotannins from Fucus vesiculosus: Modulation of Inflammatory Response by Blocking NF-¿B Signaling Pathway

Marcelo D. Catarino; Ana Silva; Maria T. Cruz; Nuno Mateus; Artur M.S. Silva; Susana M. Cardoso, 2020. International Journal of Molecular Sciences. 2020. https://doi.org/10.3390/ijms21186897 . 10.3390/ijms21186897 . International Journal of Molecular Sciences

PINK1/PARKIN signalling in neurodegeneration and neuroinflammation

Quinn, Peter M. J.; Moreira, Paula I.; Ambrósio, António Francisco; Alves, C. Henrique, 2020. Acta Neuropathologica Communications. 1. 8. 2020. http://dx.doi.org/10.1186/s40478-020-01062-w . 10.1186/s40478-020-01062-w . published Acta Neuropathologica Communications

The interplay between redox signalling and proteostasis in neurodegeneration: In vivo effects of a mitochondria-targeted antioxidant in Huntington's disease mice

Pinho, Brígida R.; Duarte, Ana I.; Canas, Paula M.; Moreira, Paula I.; Murphy, Michael P.; Oliveira, Jorge M.A., 2020. Free Radical Biology and Medicine. 372 - 382. 146. 2020. http://dx.doi.org/10.1016/j.freeradbiomed.2019.11.021 . 10.1016/j.freeradbiomed.2019.11.021 . Free Radical Biology and Medicine

Associations between Trace Elements and Cognitive Decline: An Exploratory 5-Year Follow-Up Study of an Elderly Cohort

Bianca Gerardo; Marina Cabral Pinto; Joana Nogueira; Paula Pinto; Agostinho Almeida; Edgar Pinto; Paula Marinho-Reis; et al, 2020. International Journal of Environmental Research and Public Health. 2020. https://doi.org/10.3390/ijerph17176051 . 10.3390/ijerph17176051 . International Journal of Environmental Research and Public Health

New BACE1 Chimeric Peptide Inhibitors Selectively Prevent AßPPß Cleavage Decreasing Amyloid-ß Production and Accumulation in Alzheimer’s Disease Models

Resende, Rosa; Ferreira-Marques, Marisa; Moreira, Patrícia; Coimbra, Judite R.M.; Baptista, Salete J.; Isidoro, Ciro; Salvador, Jorge A.R.; et al, 2020. Journal of Alzheimer's Disease. 1317 - 1337. 6. 70. 2020. http://dx.doi.org/10.3233/jad-200381 . 10.3233/jad-200381 . published Journal of Alzheimer's Disease

NLRP3 Inflammasome and Allergic Contact Dermatitis: A Connection to Demystify

Ana Isabel Sebastião; Isabel Ferreira; Gonçalo Brites; Ana Silva; Bruno Miguel Neves; Maria Teresa Cruz, 2020. Pharmaceutics. 867 - 867. 9. 12. 2020. https://doi.org/10.3390/pharmaceutics12090867 . 10.3390/pharmaceutics12090867 . Pharmaceutics

Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing

Cunnane, Stephen C.; Trushina, Eugenia; Morland, Cecilie; Prigione, Alessandro; Casadesus, Gemma; Andrews, Zane B.; Beal, M. Flint; et al, 2020. Nature Reviews Drug Discovery. 2020. http://dx.doi.org/10.1038/s41573-020-0072-x . 10.1038/s41573-020-0072-x . Nature Reviews Drug Discovery

Anti-inflammatory potential of Portuguese thermal waters

Silva, A.; Oliveira, A. S.; Vaz, C. V.; Correia, S.; Ferreira, R.; Breitenfeld, L.; Martinez-de-Oliveira, J.; et al, 2020. Scientific Reports. 1. 10. 2020. http://dx.doi.org/10.1038/s41598-020-79394-9 . 10.1038/s41598-020-79394-9 . published Scientific Reports

Chemical signature and antimicrobial activity of Central Portuguese Natural Mineral Waters against selected skin pathogens

Oliveira, Ana Sofia; Vaz, Catia Vicente; Silva, Ana; Ferreira, Sandra Saraiva; Correia, Sara; Ferreira, Raquel; Breitenfeld, Luiza; et al, 2020. Environmental Geochemistry and Health. 2020. https://publons.com/publon/30841014/ . 10.1007/S10653-019-00473-6 . Environmental Geochemistry and Health

Characterization of the retinal changes of the 3×Tg-AD mouse model of Alzheimer's disease

Ferreira, Hugo; Martins, João; Nunes, Ana; Moreira, Paula I.; Castelo-Branco, Miguel; Ambrósio, António Francisco; Serranho, Pedro; Bernardes, Rui, 2020. Health and Technology. 2020. http://dx.doi.org/10.1007/s12553-020-00413-w . 10.1007/s12553-020-00413-w . Health and Technology

Calcium Modulation, Anti-Oxidant and Anti-Inflammatory Effect of Skin Allergens Targeting the Nrf2 Signaling Pathway in Alzheimer’s Disease Cellular Models

Silva, Ana; Pereira, Marta; Carrascal, Mylène A.; Brites, Gonçalo; Neves, Bruno; Moreira, Patrícia; Resende, Rosa; et al, 2020. International Journal of Molecular Sciences. 20. 21. 2020. http://dx.doi.org/10.3390/ijms21207791 . 10.3390/ijms21207791 . International Journal of Molecular Sciences

APOE ¿4-TOMM40L Haplotype Increases the Risk of Mild Cognitive Impairment Conversion to Alzheimer’s Disease

Cardoso, Remy; Lemos, Carolina; Oliveiros, Bárbara; Almeida, Maria Rosário; Baldeiras, Inês; Pereira, Cláudia Fragão; Santos, Ana; et al, 2020. Journal of Alzheimer's Disease. 587 - 601. 2. 78. 2020. http://dx.doi.org/10.3233/jad-200556 . 10.3233/jad-200556 . published Journal of Alzheimer's Disease

Liraglutide Protects Against Brain Amyloid-ß1-42 Accumulation in Female Mice with Early Alzheimer's Disease-Like Pathology by Partially Rescuing Oxidative/Nitrosative Stress and Inflammation

Ana I. Duarte; Emanuel Candeias; Inês N. Alves; Débora Mena; Daniela F. Silva; Nuno J. Machado; Elisa J. Campos; et al, 2020. International Journal of Molecular Sciences. 2020. https://doi.org/10.3390/ijms21051746 . 10.3390/ijms21051746 . International Journal of Molecular Sciences

Can the retina show similar molecular and cellular changes as the brain in an animal model of Alzheimer's disease?

Rodrigues-Neves, Ana Catarina; Carecho, Rafael; Baptista, Filipa; Moreira, Paula; Ambrósio, António, 2019. Frontiers in Cellular Neuroscience. 13. 2019. http://dx.doi.org/10.3389/conf.fncel.2019.01.00020 . 10.3389/conf.fncel.2019.01.00020 . Frontiers in Cellular Neuroscience

Células Estaminais Pluripotentes Induzidas no Tratamento da Doença de Alzheimer

Cruz, Maria Teresa; Marinheira, Joana; Silva, Sónia; Marinheira, Joana Filipa Rodrigues, 2019. 2019. http://www.actafarmaceuticaportuguesa.com/index.php/afp/article/view/190 .

Is Alzheimer’s disease an inflammasomopathy?

Pereira, Claudia F.; Santos, Armanda E.; Moreira, Paula I.; Pereira, Ana Catarina; Sousa, Fabio J.; Cardoso, Sandra M.; Cruz, M. Teresa, 2019. Ageing Research Reviews. 56. 2019. http://dx.doi.org/10.1016/j.arr.2019.100966 . 10.1016/j.arr.2019.100966 . Ageing Research Reviews

Biomaterial-based platforms for in situ dendritic cell programming and their use in antitumor immunotherapy

Calmeiro, Joao; Carrascal, Mylene; Gomes, Celia; Falcao, Amilcar; Cruz, Maria Teresa; Neves, Bruno Miguel; Calmeiro, J.; et al, 2019. Journal for ImmunoTherapy of Cancer. 1. 7. 2019. https://publons.com/publon/22830157/ . 10.1186/S40425-019-0716-8 . Journal for ImmunoTherapy of Cancer

Ischaemia alters the effects of cardiomyocyte-derived extracellular vesicles on macrophage activation

Paiva, Rafael Almeida; Martins-Marques, Tania; Jesus, Katia; Ribeiro-Rodrigues, Teresa; Zuzarte, Monica; Silva, Ana; Reis, Liliana; et al, 2019. Journal of Cellular and Molecular Medicine. 2019. https://publons.com/publon/18866715/ . 10.1111/JCMM.14014 . Journal of Cellular and Molecular Medicine

Apple Pomace Extract as a Sustainable Food Ingredient

Fernandes, Pedro A. R.; Ferreira, Sonia S.; Bastos, Rita; Ferreira, Isabel; Cruz, Maria T.; Pinto, Antonio; Coelho, Elisabete; et al, 2019. Antioxidants. 2019. https://publons.com/publon/26807092/ . 10.3390/ANTIOX8060189 . Antioxidants

Chemical signature and antimicrobial activity of Central Portuguese Natural Mineral Waters against selected skin pathogens

Oliveira, Ana Sofia; Vaz, Cátia Vicente; Silva, Ana; Ferreira, Sandra Saraiva; Correia, Sara; Ferreira, Raquel; Breitenfeld, Luiza; et al, 2019. Environmental Geochemistry and Health. 2019. http://dx.doi.org/10.1007/s10653-019-00473-6 . 10.1007/s10653-019-00473-6 . published Environmental Geochemistry and Health

Unveiling the Antifungal Potential of Two Iberian Thyme Essential Oils: Effect on C. albicans Germ Tube and Preformed Biofilms

Alves, Melissa; Goncalves, Maria Jose; Zuzarte, Monica; Alves-Silva, Jorge M.; Cavaleiro, Carlos; Cruz, Maria Teresa; Salgueiro, Ligia, 2019. Frontiers in Pharmacology. 2019. https://publons.com/publon/22754016/ . 10.3389/FPHAR.2019.00446 . Frontiers in Pharmacology

Post-translational modifications in brain health and disease

Correia, Sónia C.; Carvalho, Cristina; Cardoso, Susana; Moreira, Paula I., 2019. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1947 - 1948. 8. 1865. 2019. http://dx.doi.org/10.1016/j.bbadis.2019.05.006 . 10.1016/j.bbadis.2019.05.006 . Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Tortuous Paths of Insulin Signaling and Mitochondria in Alzheimer's Disease.

Moreira, PI, 2019. Advances in experimental medicine and biology. 2019. https://doi.org/10.1007/978-981-13-3540-2_9 . 10.1007/978-981-13-3540-2_9 . Advances in experimental medicine and biology

Is Alzheimer's disease an inflammasomopathy?

Pereira, C.F.; Santos, A.E.; Moreira, P.I.; Pereira, A.C.; Sousa, F.J.; Cardoso, S.M.; Cruz, M.T.; et al, 2019. Ageing Research Reviews. 56. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85072809334&partnerID=MN8TOARS . 10.1016/j.arr.2019.100966 . Ageing Research Reviews

Development of a novel dendritic cell-based immunotherapy targeting cancer stem cells

Calmeiro, Joao; Carrascal, Mylene; Mendes, Luis; Duarte, Iola F.; Gomes, Celia; Serra, Joao; Falcao, Amilcar; Cruz, Maria Teresa; Neves, Bruno Miguel, 2019. Journal of Clinical Oncology. 2019. https://publons.com/publon/21604203/ . 10.1200/JCO.2019.37.15_SUPPL.E14009 . Journal of Clinical Oncology

The Retina as a Window or Mirror of the Brain Changes Detected in Alzheimer's Disease: Critical Aspects to Unravel

Chiquita, Samuel; Rodrigues-Neves, Ana C.; Baptista, Filipa I.; Carecho, Rafael; Moreira, Paula I.; Castelo-Branco, Miguel; Ambrósio, António F., 2019. Molecular Neurobiology. 5416 - 5435. 8. 56. 2019. http://dx.doi.org/10.1007/s12035-018-1461-6 . 10.1007/s12035-018-1461-6 . Molecular Neurobiology

The cellular stress response in the immune system

Pereira, Claudia; Pereira, Ana Catarina; Ferreira, Isabel; Neves, Bruno; Morais, Sofia; Madeira, Nuno; Santos, Vitor; Macedo, Antonio; Cruz, Maria Teresa, 2019. European Journal of Clinical Investigation. 2019. https://publons.com/publon/26807090/ . European Journal of Clinical Investigation

Apple pomace extract as a sustainable food ingredient

Fernandes, P.A.R.; Ferreira, S.S.; Bastos, R.; Ferreira, I.; Cruz, M.T.; Pinto, A.; Coelho, E.; et al, 2019. Antioxidants. 6. 8. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85069685332&partnerID=MN8TOARS . 10.3390/antiox8060189 . Antioxidants

Nanostructuring lipid carriers using Ridolfia segetum (L.) Moris essential oil

Miranda, M.; Cruz, M.T.; Vitorino, C.; Cabral, C.; Miranda, Margarida; Cruz, Maria Teresa; Vitorino, Carla; Cabral, Celia, 2019. Materials Science and Engineering C. 103. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85066465144&partnerID=MN8TOARS . 10.1016/j.msec.2019.109804 . Materials Science and Engineering C

Diminished O-GlcNAcylation in Alzheimer's disease is strongly correlated with mitochondrial anomalies

Pinho, Tiffany S.; Correia, Sónia C.; Perry, George; Ambrósio, António Francisco; Moreira, Paula I., 2019. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2048 - 2059. 8. 1865. 2019. http://dx.doi.org/10.1016/j.bbadis.2018.10.037 . 10.1016/j.bbadis.2018.10.037 . Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

A defined approach for skin sensitization potency integrating in silico, in chemico and in vitro cell data

Ferreira, I.; Brites, G.; Silva, A.; Cruz, M. T.; Neves, B. M., 2019. Toxicology Letters. 2019. https://publons.com/publon/26807094/ . Toxicology Letters

Chimeric Antigenic Receptor (CAR) T Cells: A New Immunotherapeutic Strategy

Cruz, Maria Teresa; Mateus, Daniela Marques; Borges, Olga, 2019. 2019. http://revista.farmacoterapia.pt/index.php/rpf/article/view/222 . 10.25756/rpf.v11i2-3.219 .

The Eighth ECS Workshop on “Calcium Signaling in Aging and Neurodegenerative Diseases”

Jan Parys; C Pereira; Carlos Villalobos, 2019. International Journal of Molecular Sciences. 2019. https://www.mdpi.com/1422-0067/20/24/6263 . 10.3390/ijms20246263 . International Journal of Molecular Sciences

Retinal thickness of the triple-transgenic mice model of Alzheimer's disease at the age of one month

Bernardes, Rui; Ferreira, Hugo; Martins, João; Moreira, Paula I.; Castelo-Branco, Miguel; Ambrósio, António F.; Serranho, Pedro, 2019. Acta Ophthalmologica. S263. 97. 2019. http://dx.doi.org/10.1111/j.1755-3768.2019.5467 . 10.1111/j.1755-3768.2019.5467 . Acta Ophthalmologica

Unveiling the bioactive potential of the essential oil of a Portuguese endemism, Santolina impressa

Alves-Silva, J.M.; Zuzarte, M.; Gonçalves, M.J.; Cruz, M.T.; Cavaleiro, C.; Salgueiro, L.; Alves-Silva, J. M.; Goncalves, M. J.; Cruz, M. T., 2019. Journal of Ethnopharmacology. 244. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85070094953&partnerID=MN8TOARS . 10.1016/j.jep.2019.112120 . Journal of Ethnopharmacology

Diabesity and brain disturbances: A metabolic perspective

Susana Cardoso; Paula I. Moreira, 2019. Molecular Aspects of Medicine. 71 - 79. 66. 2019. https://doi.org/10.1016/j.mam.2018.10.002 . 10.1016/j.mam.2018.10.002 . Molecular Aspects of Medicine

An overview of glutaminyl cyclase inhibitors for Alzheimer’s disease

Coimbra, Judite RM; Sobral, Pedro JM; Santos, Armanda E; Moreira, Paula I; Salvador, Jorge AR, 2019. Future Medicinal Chemistry. 3179 - 3194. 24. 11. 2019. http://dx.doi.org/10.4155/fmc-2019-0163 . 10.4155/fmc-2019-0163 . Future Medicinal Chemistry

Oxidized phosphatidylserine mitigates LPS-triggered macrophage inflammatory status through modulation of JNK and NF-kB signaling cascades

Maciel, Elisabete; Neves, Bruno M.; Martins, Joao; Colombo, Simone; Cruz, Maria Teresa; Domingues, Pedro; Domingues, M. Rosario M.; Cruz, Maria Teresa, 2019. Cellular Signalling. 2019. https://publons.com/publon/20224929/ . 10.1016/J.CELLSIG.2019.04.015 . Cellular Signalling

Links between Cognitive Status and Trace Element Levels in Hair for an Environmentally Exposed Population: A Case Study in the Surroundings of the Estarreja Industrial Area

Cabral Pinto, Marina M. S.; Marinho-Reis, Paula; Almeida, Agostinho; Pinto, Edgar; Neves, Orquídia; Inácio, Manuela; Gerardo, Bianca; et al, 2019. International Journal of Environmental Research and Public Health. 22. 16. 2019. http://dx.doi.org/10.3390/ijerph16224560 . 10.3390/ijerph16224560 . International Journal of Environmental Research and Public Health

Is Alzheimer's disease an inflammasomopathy?

Pereira, Claudia F.; Santos, Armanda E.; Moreira, Paula I.; Pereira, Ana Catarina; Sousa, Fabio J.; Cardoso, Sandra M.; Cruz, M. Teresa, 2019. Ageing Research Reviews. 56. 2019. http://dx.doi.org/10.1016/j.arr.2019.100966 . 10.1016/j.arr.2019.100966 . Ageing Research Reviews

Retinal thinning of inner sub-layers is associated with cortical atrophy in a mouse model of Alzheimer's disease: a longitudinal multimodal in vivo study

Chiquita, Samuel; Campos, Elisa J.; Castelhano, João; Ribeiro, Mário; Sereno, José; Moreira, Paula I.; Castelo-Branco, Miguel; Ambrósio, António Francisco, 2019. Alzheimer's Research & Therapy. 1. 11. 2019. http://dx.doi.org/10.1186/s13195-019-0542-8 . 10.1186/s13195-019-0542-8 . Alzheimer's Research & Therapy

A longitudinal multimodal in vivo molecular imaging study of the 3xTg-AD mouse model shows progressive early hippocampal and taurine loss

Chiquita, Samuel; Ribeiro, Mário; Castelhano, João; Oliveira, Francisco; Sereno, José; Batista, Marta; Abrunhosa, Antero; et al, 2019. Human Molecular Genetics. 2174 - 2188. 13. 28. 2019. http://dx.doi.org/10.1093/hmg/ddz045 . 10.1093/hmg/ddz045 . Human Molecular Genetics

Unveiling the antifungal potential of two iberian thyme essential oils: Effect on C. albicans germ tube and preformed biofilms

Alves, M.; Gonçalves, M.J.; Zuzarte, M.; Alves-Silva, J.M.; Cavaleiro, C.; Cruz, M.T.; Salgueiro, L., 2019. Frontiers in Pharmacology. MAY. 10. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85068820197&partnerID=MN8TOARS . 10.3389/fphar.2019.00446 . Frontiers in Pharmacology

The beneficial role of exercise in mitigating doxorubicin-induced Mitochondrionopathy

Marques-Aleixo, I.; Santos-Alves, E.; Oliveira, P.J.; Moreira, P.I.; Magalhães, J.; Ascensão, A., 2018. Biochimica et Biophysica Acta - Reviews on Cancer. 189 - 199. 2. 1869. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85041805508&partnerID=MN8TOARS . 10.1016/j.bbcan.2018.01.002 . Biochimica et Biophysica Acta - Reviews on Cancer

Dual Therapy with Liraglutide and Ghrelin Promotes Brain and Peripheral Energy Metabolism in the R6/2 Mouse Model of Huntington's Disease

Ana I. Duarte; Marie Sjögren; Maria S. Santos; Catarina R. Oliveira; Paula I. Moreira; Maria Björkqvist, 2018. Scientific Reports. 1. 8. 2018. https://doi.org/10.1038/s41598-018-27121-w . 10.1038/s41598-018-27121-w . Scientific Reports

Beneficial effects of white wine polyphenols-enriched diet on Alzheimer's disease-like pathology

Mendes, D.; Oliveira, M.M.; Moreira, P.I.; Coutinho, J.; Nunes, F.M.; Pereira, D.M.; Valentão, P.; Andrade, P.B.; Videira, R.A., 2018. Journal of Nutritional Biochemistry. 165 - 177. 55. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85043298266&partnerID=MN8TOARS . 10.1016/j.jnutbio.2018.02.001 . Journal of Nutritional Biochemistry

New insights on the anti-inflammatory potential and safety profile of Thymus carnosus and Thymus camphoratus essential oils and their main compounds

Zuzarte, M.; Alves-Silva, J.M.; Alves, M.; Cavaleiro, C.; Salgueiro, L.; Cruz, M.T.; Zuzarte, Monica; et al, 2018. Journal of Ethnopharmacology. 10 - 17. 225. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85049324707&partnerID=MN8TOARS . 10.1016/j.jep.2018.06.025 . Journal of Ethnopharmacology

Polyphenolic characterisation and bioactivity of an Oxalis pes-caprae L. leaf extract

Gaspar, M.C.; Fonseca, D.A.; Antunes, M.J.; Frigerio, C.; Gomes, N.G.M.; Vieira, M.; Santos, A.E.; et al, 2018. Natural Product Research. 732 - 738. 6. 32. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021073702&partnerID=MN8TOARS . 10.1080/14786419.2017.1335728 . Natural Product Research

O-GlcNAcylation and neuronal energy status: Implications for Alzheimer's disease

Tiffany S. Pinho; Diogo M. Verde; Sónia C. Correia; Susana M. Cardoso; Paula I. Moreira, 2018. Ageing Research Reviews. 32 - 41. 46. 2018. https://doi.org/10.1016/j.arr.2018.05.003 . 10.1016/j.arr.2018.05.003 . Ageing Research Reviews

Brain insulin signalling, glucose metabolism and females' reproductive aging: A dangerous triad in Alzheimer's disease

Duarte, A.I.; Santos, M.S.; Oliveira, C.R.; Moreira, P.I., 2018. Neuropharmacology. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85044268663&partnerID=MN8TOARS . 10.1016/j.neuropharm.2018.01.044 . Neuropharmacology

Sweet Mitochondria: A Shortcut to Alzheimer's Disease

Moreira, P.I., 2018. Journal of Alzheimer's Disease. 1391 - 1401. 3. 62. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85044360897&partnerID=MN8TOARS . 10.3233/JAD-170931 . Journal of Alzheimer's Disease

Acanthus mollis L. leaves as source of anti-inflammatory and antioxidant phytoconstituents

Cruz, Maria Teresa, 2018. 2018. http://dx.doi.org/10.1080/14786419.2018.1437438 . 10.1080/14786419.2018.1437438 .

Editorial: The Physiology of Inflammation-The Final Common Pathway to Disease

Ferreira Mendes, Alexandrina; Teresa Cruz, Maria; Gualillo, Oreste; Mendes, Alexandrina Ferreira; Cruz, Maria Teresa, 2018. Frontiers in Physiology. 2018. https://publons.com/publon/18596785/ . 10.3389/FPHYS.2018.01741 . Frontiers in Physiology

Nature and kinetics of redox imbalance triggered by respiratory and skin chemical sensitizers on the human monocytic cell line THP-1

Ferreira, Isabel; Silva, Ana; Martins, Joao Demetrio; Neves, Bruno Miguel; Cruz, Maria Teresa; Cruz, Maria Teresa, 2018. Redox Biology. 2018. https://publons.com/publon/16980300/ . 10.1016/J.REDOX.2018.02.002 . Redox Biology

Impact of different GMP media in the production of dendritic cells for next-generation cancer immunotherapy: Functional and metabolic characterization

Calmeiro, J.; Carrascal, M.; Gomes, C.; Falcao, A.; Serra, J.; Cruz, M. T.; Neves, B., 2018. Annals of Oncology. 2018. https://publons.com/publon/26807098/ . Annals of Oncology

Exosomes as adjuvants for the recombinant hepatitis B antigen: First report

Sandra Jesus; Edna Soares; Maria Teresa Cruz; Olga Borges; Jesus, Sandra; Soares, Edna; Cruz, Maria Teresa; Borges, Olga, 2018. European Journal of Pharmaceutics and Biopharmaceutics. 1 - 11. 133. 2018. https://doi.org/10.1016/j.ejpb.2018.09.029 . 10.1016/j.ejpb.2018.09.029 . European Journal of Pharmaceutics and Biopharmaceutics

New Insights into the Anti-Inflammatory and Antioxidant Properties of Nitrated Phospholipids

Melo, Tania; Marques, Sara S.; Ferreira, Isabel; Cruz, Maria Teresa; Domingues, Pedro; Segundo, Marcela A.; Marques Domingues, Maria Rosario; et al, 2018. Lipids. 117 - 131. 1. 53. 2018. https://publons.com/publon/3423064/ . 10.1002/LIPD.12007 . Lipids

Bioactivity of Acanthus mollis – Contribution of benzoxazinoids and phenylpropanoids

Cruz, Maria Teresa, 2018. 2018. http://dx.doi.org/10.1016/j.jep.2018.09.013 . 10.1016/j.jep.2018.09.013 .

Fingernail Trace Element Content in Environmentally Exposed Individuals and Its Influence on Their Cognitive Status in Ageing

Cabral Pinto, Marina M. S.; Marinho-Reis, A. Paula; Almeida, Agostinho; Freitas, Sandra; Simões, Mário R.; Diniz, M. Luísa; Pinto, Edgar; et al, 2018. Exposure and Health. 181 - 194. 3. 11. 2018. http://dx.doi.org/10.1007/s12403-018-0274-1 . 10.1007/s12403-018-0274-1 . Exposure and Health

Contact dermatitis: in pursuit of sensitizer’s molecular targets through proteomics

Guedes, S.; Neves, B.; Vitorino, R.; Domingues, R.; Cruz, M.T.; Domingues, P.; Guedes, Sofia; et al, 2017. Archives of Toxicology. 811 - 825. 2. 91. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-84964645560&partnerID=MN8TOARS . 10.1007/s00204-016-1714-y . Archives of Toxicology

Selenoprotein S Reduces Endoplasmic Reticulum Stress-Induced Phosphorylation of Tau: Potential Role in Selenate Mitigation of Tau Pathology

Rueli, R.H.L.H.; Torres, D.J.; Dewing, A.S.T.; Kiyohara, A.C.; Barayuga, S.M.; Bellinger, M.T.; Uyehara-Lock, J.H.; et al, 2017. Journal of Alzheimer's Disease. 749 - 762. 2. 55. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-84999116043&partnerID=MN8TOARS . 10.3233/JAD-151208 . Journal of Alzheimer's Disease

Insights into the human brain proteome: Disclosing the biological meaning of protein networks in cerebrospinal fluid

Bastos, P.; Ferreira, R.; Manadas, B.; Moreira, P.I.; Vitorino, R., 2017. Critical Reviews in Clinical Laboratory Sciences. 185 - 204. 3. 54. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85019117156&partnerID=MN8TOARS . 10.1080/10408363.2017.1299682 . Critical Reviews in Clinical Laboratory Sciences

Phosphatase 2A Inhibition Affects Endoplasmic Reticulum and Mitochondria Homeostasis Via Cytoskeletal Alterations in Brain Endothelial Cells

Ana I. Plácido; Cláudia M. F. Pereira; Sónia C. Correira; Cristina Carvalho; Catarina R. Oliveira; Paula I. Moreira, 2017. Molecular Neurobiology. 2017. http://dx.doi.org/10.1007/s12035-015-9640-1 . 10.1007/s12035-015-9640-1 . Molecular Neurobiology

Lipophilic Fraction of Cultivated Bifurcaria bifurcata R. Ross: Detailed Composition and In Vitro Prospection of Current Challenging Bioactive Properties

Santos, Sonia A. O.; Trindade, Stephanie S.; Oliveira, Catia S. D.; Parreira, Paula; Rosa, Daniela; Duarte, Maria F.; Ferreira, Isabel; et al, 2017. Marine Drugs. 2017. https://publons.com/publon/4614900/ . 10.3390/MD15110340 . Marine Drugs

Antioxidant, Anti-Inflammatory, and Analgesic Activities of Agrimonia eupatoria L. Infusion

Telmo N. Santos; Gustavo Costa; J. Pinto Ferreira; Joana Liberal; Vera Francisco; António Paranhos; Maria T. Cruz; et al, 2017. Evidence-Based Complementary and Alternative Medicine. 2017. 10.1155/2017/8309894 . Evidence-Based Complementary and Alternative Medicine

Brain GLP-1/IGF-1 Signaling and Autophagy Mediate Exendin-4 Protection Against Apoptosis in Type 2 Diabetic Rats

Candeias, Emanuel; Sebastião, Inês; Cardoso, Susana; Carvalho, Cristina; Santos, Maria Sancha; Oliveira, Catarina Resende; Moreira, Paula I.; Duarte, Ana I., 2017. Molecular Neurobiology. 2017. http://dx.doi.org/10.1007/s12035-017-0622-3 . 10.1007/s12035-017-0622-3 . Molecular Neurobiology

Inflammasome in dendritic cells immunobiology: Implications to diseases and therapeutic strategies

Ferreira, I.; Liberal, J.; Martins, J.D.; Silva, A.; Neves, B.M.; Cruz, M.T., 2017. Current Drug Targets. 1003 - 1018. 9. 18. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85022193483&partnerID=MN8TOARS . 10.2174/1389450117666160921144830 . Current Drug Targets

Antioxidant and anti-inflammatory activities of: Geranium robertianum L. decoctions

Catarino, M.D.; Silva, A.M.S.; Cruz, M.T.; Cardoso, S.M.; Marcelo D. Catarino; Artur M. S. Silva; Maria Teresa Cruz; Susana M. Cardoso, 2017. Food and Function. 3355 - 3365. 9. 8. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85029740286&partnerID=MN8TOARS . 10.1039/c7fo00881c . Food and Function

Chemical composition of Laurencia obtusa extract and isolation of a new C<inf>15</inf>-acetogenin

Esselin, H.; Sutour, S.; Libera, J.; Cruz, M.T.; Salgueiro, L.; Siegler, B.; Freuze, I.; et al, 2017. Molecules. 5. 22. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85020221958&partnerID=MN8TOARS . 10.3390/molecules22050779 . Molecules

Human predisposition to cognitive impairment and its relation with environmental exposure to potentially toxic elements

Cabral Pinto, M.M.S.; Marinho-Reis, A.P.; Almeida, A.; Ordens, C.M.; Silva, M.M.V.G.; Freitas, S.; Simões, M.R.; et al, 2017. Environmental Geochemistry and Health. 1 - 18. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85014615707&partnerID=MN8TOARS . 10.1007/s10653-017-9928-3 . Environmental Geochemistry and Health

Lipophilic fraction of cultivated Bifurcaria bifurcata R. Ross: Detailed composition and in vitro prospection of current challenging bioactive properties

Santos, S.A.O.; Trindade, S.S.; Oliveira, C.S.D.; Parreira, P.; Rosa, D.; Duarte, M.F.; Ferreira, I.; et al, 2017. Marine Drugs. 11. 15. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85036574775&partnerID=MN8TOARS . 10.3390/md15110340 . Marine Drugs

Assessment of safe bioactive doses of Foeniculum vulgare Mill. essential oil from Portugal

Cabral, C.; Miranda, M.; Gonçalves, M.J.; Cavaleiro, C.; Cruz, M.T.; Salgueiro, L., 2017. Natural Product Research. 2654 - 2659. 22. 31. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85014579756&partnerID=MN8TOARS . 10.1080/14786419.2017.1292266 . Natural Product Research

Urolithins impair cell proliferation, arrest the cell cycle and induce apoptosis in UMUC3 bladder cancer cells

Liberal, Joana; Carmo, Analia; Gomes, Celia; Cruz, Maria Teresa; Batista, Maria Teresa; Liberal, J.; Carmo, A.; et al, 2017. Investigational New Drugs. 671 - 681. 6. 35. 2017. https://publons.com/publon/10621860/ . 10.1007/S10637-017-0483-7 . Investigational New Drugs

Valorization of Lipids from Gracilaria sp through Lipidomics and Decoding of Antiproliferative and Anti-Inflammatory Activity

da Costa, Elisabete; Melo, Tania; Moreira, Ana S. P.; Bernardo, Carina; Helguero, Luisa; Ferreira, Isabel; Cruz, Maria Teresa; et al, 2017. Marine Drugs. 2017. https://publons.com/publon/3423052/ . 10.3390/MD15030062 . Marine Drugs

Urtica spp.: Phenolic composition, safety, antioxidant and anti-inflammatory activities

Carvalho, Ana Rita; Costa, Gustavo; Figueirinha, Artur; Liberal, Joana; Prior, Joao A. V.; Lopes, Maria Celeste; Cruz, Maria Teresa; et al, 2017. Food Research International. 485 - 494. 99. 2017. https://publons.com/publon/10621866/ . 10.1016/J.FOODRES.2017.06.008 . Food Research International

Chemical Composition of Laurencia obtusa Extract and Isolation of a New C-15-Acetogenin

Esselin, Helene; Sutour, Sylvain; Liberal, Joana; Cruz, Maria Teresa; Salgueiro, Ligia; Siegler, Benjamin; Freuze, Ingrid; et al, 2017. Molecules. 2017. https://publons.com/publon/10621865/ . 10.3390/MOLECULES22050779 . Molecules

Dendritic cell-based immunotherapy: a basic review and recent advances

Constantino, Joao; Gomes, Celia; Falcao, Amilcar; Neves, Bruno Miguel; Cruz, Maria Teresa; Constantino, J.; Gomes, C.; et al, 2017. Immunologic Research. 798 - 810. 4. 65. 2017. https://publons.com/publon/9962888/ . 10.1007/S12026-017-8931-1 . Immunologic Research

In vitro macrophage nitric oxide production by Pterospartum tridentatum (L.) Willk. inflorescence polysaccharides

Martins, Vitor M. R.; Simoes, Joana; Ferreira, Isabel; Cruz, Maria Teresa; Rosario Domingues, M.; Coimbra, Manuel A.; Martins, V.M.R.; et al, 2017. Carbohydrate Polymers. 176 - 184. 157. 2017. https://publons.com/publon/953728/ . 10.1016/J.CARBPOL.2016.09.079 . Carbohydrate Polymers

Uncoupling Protein 2 Inhibition Exacerbates Glucose Fluctuation-Mediated Neuronal Effects

Cardoso, S.; Seiça, R.M.; Moreira, P.I., 2017. Neurotoxicity Research. 1 - 14. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85028984223&partnerID=MN8TOARS . 10.1007/s12640-017-9805-y . Neurotoxicity Research

Mitochondria as a target for neuroprotection: implications for Alzheimer´s disease

Cardoso, S.; Seiça, R.M.; Moreira, P.I., 2017. Expert Review of Neurotherapeutics. 77 - 91. 1. 17. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85003782022&partnerID=MN8TOARS . 10.1080/14737175.2016.1205488 . Expert Review of Neurotherapeutics

Valorization of lipids from Gracilaria sp. through lipidomics and decoding of antiproliferative and anti-inflammatory activity

Da Costa, E.; Melo, T.; Moreira, A.S.P.; Bernardo, C.; Helguero, L.; Ferreira, I.; Cruz, M.T.; et al, 2017. Marine Drugs. 3. 15. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85016479252&partnerID=MN8TOARS . 10.3390/md15030062 . Marine Drugs

Phosphatase 2A Inhibition Affects Endoplasmic Reticulum and Mitochondria Homeostasis Via Cytoskeletal Alterations in Brain Endothelial Cells

Placido, Ana I.; Pereira, Claudia M. F.; Correira, Sonia C.; Carvalho, Cristina; Oliveira, Catarina R.; Moreira, Paula I., 2017. Molecular Neurobiology. 154 - 168. 1. 54. 2017. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000392133900014&KeyUID=WOS:000392133900014 . 10.1007/s12035-015-9640-1 . Molecular Neurobiology

When, where and how: mitochondrial multifaceted dysfunction in Alzheimer's disease

Oliveira, C. R.; Pereira, C.; Rego, A. C.; Moreira, P. I.; Cardoso, S., 2017. European Journal of Clinical Investigation. 24 - 25. 47. 2017. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000412099900035&KeyUID=WOS:000412099900035 . European Journal of Clinical Investigation

Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

Klionsky, D.J.; Abeliovich, H.; Agostinis, P.; Agrawal, D.K.; Aliev, G.; Askew, D.S.; Baba, M.; et al, 2016. Autophagy. 2. 12. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84975859238&partnerID=MN8TOARS . 10.1080/15548627.2016.1147886 . Autophagy

IMMUNOMODULATORY ACTION OF PROPOLIS ON MAGE-1-INDUCED-CYTOKINE PRODUCTION BY HUMAN MONOCYTES

Santiago, K. B.; Conti, B. J.; Conte, F. L.; Oliveira, L. P. G.; Cardoso, E. O.; Cruz, M. T.; Sforcin, J. M., 2016. Cytokine. 2016. https://publons.com/publon/10621873/ . Cytokine

Mitochondrial traffic jams in Alzheimer's disease - pinpointing the roadblocks

Correia, S.C.; Perry, G.; Moreira, P.I., 2016. Biochimica et Biophysica Acta - Molecular Basis of Disease. 1909 - 1917. 10. 1862. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84979699672&partnerID=MN8TOARS . 10.1016/j.bbadis.2016.07.010 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Alzheimer's Disease: From Mitochondrial Perturbations to Mitochondrial Medicine

Cardoso, S.; Carvalho, C.; Correia, S.C.; Seiça, R.M.; Moreira, P.I., 2016. Brain Pathology. 632 - 647. 5. 26. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84988642816&partnerID=MN8TOARS . 10.1111/bpa.12402 . Brain Pathology

BRAZILIAN PROPOLIS MODULATES CYTOKINE PRODUCTION BY LPS-ACTIVATED HUMAN MONOCYTES

Conti, B. J.; Santiago, K. B.; Conte, F. L.; Cardoso, E. O.; Oliveira, L. P. G.; Cruz, M. T.; Sforcin, J. M., 2016. Cytokine. 2016. https://publons.com/publon/10621855/ . Cytokine

Middle-Aged Diabetic Females and Males Present Distinct Susceptibility to Alzheimer Disease-like Pathology

Candeias, E.; Duarte, A.I.; Sebastião, I.; Fernandes, M.A.; Plácido, A.I.; Carvalho, C.; Correia, S.; et al, 2016. Molecular Neurobiology. 1 - 19. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84991075553&partnerID=MN8TOARS . 10.1007/s12035-016-0155-1 . Molecular Neurobiology

Ziziphora tenuior L. essential oil from Dana Biosphere Reserve (Southern Jordan); Chemical characterization and assessment of biological activities

Abu-Darwish, M.S.; Cabral, C.; Gonçalves, M.J.; Cavaleiro, C.; Cruz, M.T.; Paoli, M.; Tomi, F.; et al, 2016. Journal of Ethnopharmacology. 963 - 970. 194. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-85003967187&partnerID=MN8TOARS . 10.1016/j.jep.2016.10.076 . Journal of Ethnopharmacology

Chemical composition and biological activities of Artemisia judaica essential oil from southern desert of Jordan

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PROPOLIS ACTION IN CYTOKINE PRODUCTION BY RETINOIC ACID-STIMULATED HUMAN MONOCYTES

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Phospholipidomic Profile Variation on THP-1 Cells Exposed to Skin or Respiratory Sensitizers and Respiratory Irriant

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Alzheimer's Disease-Related Misfolded Proteins and Dysfunctional Organelles on Autophagy Menu

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Metabolic fingerprints in testicular biopsies from type 1 diabetic patients

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The role of mitochondrial disturbances in Alzheimer, Parkinson and Huntington diseases

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Cymbopogon citratus industrial waste as a potential source of bioactive compounds.

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A beta and NMDAR activation cause mitochondrial dysfunction involving ER calcium release

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Antifungal and anti-inflammatory claims for wild carrot essential oil

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Loss of proteostasis induced by amyloid beta peptide in brain endothelial cells

Fonseca, Ana Catarina; Oliveira, Catarina R.; Pereira, Claudia F.; Cardoso, Sandra M., 2014. Biochimica Et Biophysica Acta-Molecular Cell Research. 1150 - 1161. 6. 1843. 2014. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000335627900010&KeyUID=WOS:000335627900010 . 10.1016/j.bbamcr.2014.02.016 . Biochimica Et Biophysica Acta-Molecular Cell Research

Oxidative stress-dependent activation of the eIF2a-ATF4 UPR branch by skin sensitizer DNFB modulates dendritic-like cell maturation and inflammatory status in a biphasic manner.

Luís A; Martins JD; Silva A; Ferreira I; Cruz MT; Neves BM, 2014. 2014. http://europepmc.org/abstract/med/25236743 .

The effect of neurotensin in human keratinocytes--implication on impaired wound healing in diabetes.

Moura LI; Cruz MT; Carvalho E, 2014. 2014. http://europepmc.org/abstract/med/24198343 . 10.1177/1535370213510665 .

Detection of phosphatidylserine with a modified polar head group in human keratinocytes exposed to the radical generator AAPH

Cruz, Maria Teresa, 2014. Arch Biochem Biophys. 2014. 10.1016/j.abb.2014.02.002 . Arch Biochem Biophys

Bioactivity of Fragaria vesca leaves through inflammation, proteasome and autophagy modulation.

Liberal J; Francisco V; Costa G; Figueirinha A; Amaral MT; Marques C; Girão H; et al, 2014. 2014. http://europepmc.org/abstract/med/25305515 . 10.1016/j.jep.2014.09.043 .

Respiratory sensitizer hexamethylene diisocyanate inhibits SOD 1 and induces ERK-dependent detoxifying and maturation pathways in dendritic-like cells.

Silva A; Nunes C; Martins J; Dinis TC; Lopes C; Neves B; Cruz T, 2014. 2014. http://europepmc.org/abstract/med/24742817 . 10.1016/j.freeradbiomed.2014.04.005 .

Protective Effect of Leptin and Ghrelin against Toxicity Induced by Amyloid- beta Oligomers in a Hypothalamic cell Line

Gomes, S.; Martins, I.; Fonseca, A. C. R. G.; Oliveira, C. R.; Resende, R.; Pereira, C. M. F., 2014. Journal of Neuroendocrinology. 176 - 185. 3. 26. 2014. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000333329700004&KeyUID=WOS:000333329700004 . 10.1111/jne.12138 . Journal of Neuroendocrinology

MISFOLDED BRI2 ECTODOMAIN ACTIVATES CRITICAL PATHOLOGICAL PATHWAYS INVOLVED IN EARLY STAGES OF ALZHEIMER'S DISEASE

Campo Milan, Marta Del; Pereira, Cláudia; Scheper, W.; Zwart, R.; Hoozemans, Jeroen; Oliveira, Catarina; Teunissen, Charlotte, 2014. Alzheimer's & Dementia. 4. 10. 2014. http://dx.doi.org/10.1016/j.jalz.2014.05.323 . 10.1016/j.jalz.2014.05.323 . published Alzheimer's & Dementia

Assessment of the properties of the essential oil from Ridolfia segetum Moris (Portugal) on cancer cell viability

Pocas, J.; Lemos, M.; Cabral, C.; Cavaleiro, C.; Cruz, M. T.; Salgueiro, L.; Pires, I., 2014. Planta Medica. 1425 - 1426. 16. 80. 2014. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000345550400227&KeyUID=WOS:000345550400227 . 10.1055/S-0034-1394701 . Planta Medica

Bioactive polyphenols from cork industry by-products

Ferreira, I. V.; Liberal, J.; Santos, T.; Silva, S.; Cruz, M. T.; Batista, M. T., 2014. Planta Medica. 1506 - 1506. 16. 80. 2014. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000345550400477&KeyUID=WOS:000345550400477 . 10.1055/S-0034-1394951 . Planta Medica

Anti-inflammatory effects of Thymus zygis subsp sylvestris essential oil in LPS-stimulated macrophages and microglia cells

Rodrigues, V.; Cabral, C.; Evora, L.; Ferreira, I.; Pereira, C.; Cavaleiro, C.; Cruz, M. T.; Salgueiro, L., 2014. Planta Medica. 1436 - 1437. 16. 80. 2014. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000345550400263&KeyUID=WOS:000345550400263 . Planta Medica

Anti-inflammatory potential of the essential oil of the Iberian endemism Thymus carnosus

Alves, M.; Zuzarte, M.; Goncalves, M. J.; Cruz, M. T.; Cavaleiro, C.; Salgueiro, L., 2014. Planta Medica. 1448 - 1448. 16. 80. 2014. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000345550400299&KeyUID=WOS:000345550400299 . 10.1055/S-0034-1394773 . Planta Medica

Antifungal and anti-inflammatory claims for wild carrot essential oil

Valente, J.; Resende, R.; Zuzarte, M.; Goncalves, M. J.; Lopes, M. C.; Cavaleiro, C.; Pereira, C.; Salgueiro, L.; Cruz, M. T., 2014. Planta Medica. 1454 - 1454. 16. 80. 2014. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000345550400318&KeyUID=WOS:000345550400318 . 10.1055/S-0034-1394792 . Planta Medica

Neurotensin decreases the proinflammatory status of human skin fibroblasts and increases epidermal growth factor expression.

Pereira da Silva L; Miguel Neves B; Moura L; Cruz MT; Carvalho E, 2014. 2014. http://europepmc.org/abstract/med/25180119 . 10.1155/2014/248240 .

Drugs inducing T-cell mediated cutaneous adverse reactions and contact sensitizers evoke similar responses in THP-1 cells.

Gonçalo M; Martins J; Silva A; Neves B; Cruz T; Lopes C, 2014. 2014. http://europepmc.org/abstract/PMC/PMC4128176 . 10.1186/2045-7022-4-S3-P50 .

Pre-diabetes alters testicular PGC1-a/SIRT3 axis modulating mitochondrial bioenergetics and oxidative stress

Rato, L.; Duarte, A.I.; Tomás, G.D.; Santos, M.S.; Moreira, P.I.; Socorro, S.; Cavaco, J.E.; Alves, M.G.; Oliveira, P.F., 2014. Biochimica et Biophysica Acta - Bioenergetics. 335 - 344. 3. 1837. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84892411578&partnerID=MN8TOARS . 10.1016/j.bbabio.2013.12.008 . Biochimica et Biophysica Acta - Bioenergetics

Increased susceptibility to amyloid-ß toxicity in rat brain microvascular endothelial cells under hyperglycemic conditions

Carvalho, C.; Katz, P.S.; Dutta, S.; Katakam, P.V.G.; Moreira, P.I.; Busija, D.W., 2014. Journal of Alzheimer's Disease. 75 - 83. 1. 38. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887249119&partnerID=MN8TOARS . 10.3233/JAD-130464 . Journal of Alzheimer's Disease

Metformin in the diabetic brain: friend or foe?

Moreira, PI; Moreira, P.I., 2014. Annals of Translational Medicine. 54 - 56. 6. 2. 2014. http://dx.doi.org/10.3978/j.issn.2305-5839.2014.06.10 . 10.3978/j.issn.2305-5839.2014.06.10 . published Annals of Translational Medicine

Vascular, oxidative, and synaptosomal abnormalities during aging and the progression of type 2 diabetes

Carvalho, C.; Correia, S.C.; Santos, M.S.; Baldeiras, I.; Oliveira, C.R.; Seiça, R.; Moreira, P.I., 2014. Current Neurovascular Research. 330 - 339. 4. 11. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84925786114&partnerID=MN8TOARS . Current Neurovascular Research

Cardiolipin profile changes are associated to the early synaptic mitochondrial dysfunction in Alzheimer's disease

Monteiro-Cardoso, V.F.; Oliveira, M.M.; Melo, T.; Domingues, M.R.M.; Moreira, P.I.; Ferreiro, E.; Peixoto, F.; Videira, R.A., 2014. Journal of Alzheimer's Disease. 1375 - 1392. 4. 43. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84919926803&partnerID=MN8TOARS . 10.3233/JAD-141002 . Journal of Alzheimer's Disease

Insulin therapy modulates mitochondrial dynamics and biogenesis, autophagy and tau protein phosphorylation in the brain of type 1 diabetic rats

Santos, R.X.; Correia, S.C.; Alves, M.G.; Oliveira, P.F.; Cardoso, S.; Carvalho, C.; Duarte, A.I.; Santos, M.S.; Moreira, P.I., 2014. Biochimica et Biophysica Acta - Molecular Basis of Disease. 1154 - 1166. 7. 1842. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84899789863&partnerID=MN8TOARS . 10.1016/j.bbadis.2014.04.011 . Biochimica et Biophysica Acta - Molecular Basis of Disease

The role of endoplasmic reticulum in amyloid precursor protein processing and trafficking: Implications for Alzheimer's disease

Plácido, A.I.; Pereira, C.M.F.; Duarte, A.I.; Candeias, E.; Correia, S.C.; Santos, R.X.; Carvalho, C.; et al, 2014. Biochimica et Biophysica Acta - Molecular Basis of Disease. 1444 - 1453. 9. 1842. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903458925&partnerID=MN8TOARS . 10.1016/j.bbadis.2014.05.003 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Effects of methylglyoxal and pyridoxamine in rat brain mitochondria bioenergetics and oxidative status

Cardoso, S.; Carvalho, C.; Marinho, R.; Simões, A.; Sena, C.M.; Matafome, P.; Santos, M.S.; Seiça, R.M.; Moreira, P.I., 2014. Journal of Bioenergetics and Biomembranes. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901509164&partnerID=MN8TOARS . 10.1007/s10863-014-9551-2 . Journal of Bioenergetics and Biomembranes

Chemical characterization and anti-inflammatory activity of luteolin glycosides isolated from lemongrass

Cruz, Maria Teresa; Francisco, Vera; Figueirinha, Artur; Costa, Gustavo; Liberal, Joana; Lopes, Maria Celeste; Garcia-Rodriguez, Carmen; et al, 2014. Journal of Functional Foods. 436 - 443. 10. 2014. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000342034200047&KeyUID=WOS:000342034200047 . doi:10.1016/j.jff.2014.07.003 . Journal of Functional Foods

Mitochondrial quality control systems sustain brain mitochondrial bioenergetics in early stages of type 2 diabetes

Santos, R.X.; Correia, S.C.; Alves, M.G.; Oliveira, P.F.; Cardoso, S.; Carvalho, C.; Seiça, R.; Santos, M.S.; Moreira, P.I., 2014. Molecular and Cellular Biochemistry. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901561690&partnerID=MN8TOARS . 10.1007/s11010-014-2076-5 . Molecular and Cellular Biochemistry

Metformin and male reproduction: Effects on Sertoli cell metabolism

Alves, M.G.; Martins, A.D.; Vaz, C.V.; Correia, S.; Moreira, P.I.; Oliveira, P.F.; Socorro, S., 2014. British Journal of Pharmacology. 1033 - 1042. 4. 171. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84893042451&partnerID=MN8TOARS . 10.1111/bph.12522 . British Journal of Pharmacology

Amyloid-Beta Disrupts Calcium and Redox Homeostasis in Brain Endothelial Cells

Fonseca, A.C.R.G.; Moreira, P.I.; Oliveira, C.R.; Cardoso, S.M.; Pinton, P.; Pereira, C.F., 2014. Molecular Neurobiology. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901537197&partnerID=MN8TOARS . 10.1007/s12035-014-8740-7 . Molecular Neurobiology

Mechanism of inhibition of mitochondrial ATP synthase by 17ß-Estradiol

Moreno, A.J.M.; Moreira, P.I.; Custódio, J.B.A.; Santos, M.S., 2013. Journal of Bioenergetics and Biomembranes. 261 - 270. 3. 45. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878642515&partnerID=MN8TOARS . 10.1007/s10863-012-9497-1 . Journal of Bioenergetics and Biomembranes

Mitochondrial-targeted protective properties of isolated diterpenoids from sideritis spp. in response to the deleterious changes induced by H 2O2

González-Burgos, E.; Duarte, A.I.; Carretero, M.E.; Moreira, P.I.; Gómez-Serranillos, M.P., 2013. Journal of Natural Products. 933 - 938. 5. 76. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878260967&partnerID=MN8TOARS . 10.1021/np400118d . Journal of Natural Products

Propolis and its constituent caffeic acid suppress LPS-stimulated pro-inflammatory response by blocking NF-¿B and MAPK activation in macrophages

Búfalo, Michelle Cristiane; Ferreira, Isabel; Costa, Gustavo; Francisco, Vera; Liberal, Joana; Cruz, Maria Teresa; Lopes, Maria Celeste; et al, 2013. Journal of Ethnopharmacology. 84 - 92. 1. 149. 2013. http://hdl.handle.net/10316/27433 . 10.1016/j.jep.2013.06.004 . Journal of Ethnopharmacology

Molecular mechanisms beyond glucose transport in diabetes-related male infertility

Alves, M.G.; Martins, A.D.; Rato, L.; Moreira, P.I.; Socorro, S.; Oliveira, P.F., 2013. Biochimica et Biophysica Acta - Molecular Basis of Disease. 626 - 635. 5. 1832. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874414576&partnerID=MN8TOARS . 10.1016/j.bbadis.2013.01.011 . Biochimica et Biophysica Acta - Molecular Basis of Disease

UCP2 and ANT differently modulate proton-leak in brain mitochondria of long-term hyperglycemic and recurrent hypoglycemic rats

Cardoso, S.; Santos, M.S.; Moreno, A.; Moreira, P.I., 2013. Journal of Bioenergetics and Biomembranes. 397 - 407. 4. 45. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84881311117&partnerID=MN8TOARS . 10.1007/s10863-013-9503-2 . Journal of Bioenergetics and Biomembranes

Cymbopogon citratus industrial waste as source of an anti-inflammatory drug

Tavares, F.; Costa, G.; Francisco, V; Cruz, M.; Batista, M., 2013. Planta Medica. 2013. https://publons.com/publon/26807100/ . 10.1055/S-0033-1352214 . Planta Medica

High-sugar diets, type 2 diabetes and Alzheimer's disease

Moreira, P.I., 2013. Current Opinion in Clinical Nutrition and Metabolic Care. 440 - 445. 4. 16. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880326722&partnerID=MN8TOARS . 10.1097/MCO.0b013e328361c7d1 . Current Opinion in Clinical Nutrition and Metabolic Care

Molecular and cellular mechanisms of bone morphogenetic proteins and activins in the skin: Potential benefits for wound healing

Moura, J.; Da Silva, L.; Cruz, M.T.; Carvalho, E., 2013. Archives of Dermatological Research. 557 - 569. 7. 305. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883240109&partnerID=MN8TOARS . 10.1007/s00403-013-1381-2 . Archives of Dermatological Research

Essential oil of common sage (Salvia officinalis L.) from Jordan: Assessment of safety in mammalian cells and its antifungal and anti-inflammatory potential

Abu-Darwish, M.S.; Cabral, C.; Ferreira, I.V.; Gonçalves, M.J.; Cavaleiro, C.; Cruz, M.T.; Al-Bdour, T.H.; Salgueiro, L., 2013. BioMed Research International. 2013. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886511600&partnerID=MN8TOARS . 10.1155/2013/538940 . BioMed Research International

New compounds, chemical composition, antifungal activity and cytotoxicity of the essential oil from Myrtus nivellei Batt. &amp; Trab.; An endemic species of Central Sahara

Bouzabata, A.; Bazzali, O.; Cabral, C.; Gonçalves, M.J.; Cruz, M.T.; Bighelli, A.; Cavaleiro, C.; et al, 2013. Journal of Ethnopharmacology. 613 - 620. 3. 149. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884415386&partnerID=MN8TOARS . 10.1016/j.jep.2013.06.054 . Journal of Ethnopharmacology

Margotia gummifera essential oil as a source of anti-inflammatory drugs

Valente, J.; Zuzarte, M.; Liberal, J.; Gonçalves, M.J.; Lopes, M.C.; Cavaleiro, C.; Cruz, M.T.; Salgueiro, L., 2013. Industrial Crops and Products. 86 - 91. 47. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875590010&partnerID=MN8TOARS . 10.1016/j.indcrop.2013.02.036 . Industrial Crops and Products

Antifungal and anti-inflammatory potential of Lavandula stoechas and Thymus herba-barona essential oils

Zuzarte, M.; Gonçalves, M.J.; Cavaleiro, C.; Cruz, M.T.; Benzarti, A.; Marongiu, B.; Maxia, A.; Piras, A.; Salgueiro, L., 2013. Industrial Crops and Products. 97 - 103. 44. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870480491&partnerID=MN8TOARS . 10.1016/j.indcrop.2012.11.002 . Industrial Crops and Products

Inhibition of mitochondrial cytochrome c oxidase potentiates Aß-induced ER stress and cell death in cortical neurons

Costa, R.O.; Ferreiro, E.; Oliveira, C.R.; Pereira, C.M.F., 2013. Molecular and Cellular Neuroscience. 1 - 8. 52. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870349573&partnerID=MN8TOARS . 10.1016/j.mcn.2012.09.005 . Molecular and Cellular Neuroscience

Exposure to 2,4-dichlorophenoxyacetic acid alters glucose metabolism in immature rat Sertoli cells

Alves, M.G.; Neuhaus-Oliveira, A.; Moreira, P.I.; Socorro, S.; Oliveira, P.F., 2013. Reproductive Toxicology. 81 - 88. 38. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876339594&partnerID=MN8TOARS . 10.1016/j.reprotox.2013.03.005 . Reproductive Toxicology

Leishmania-infected MHC class II<sup>high</sup> dendritic cells polarize CD4<sup>+</sup> T cells toward a nonprotective T-bet<sup>+</sup> IFN-¿<sup>+</sup> IL-10<sup>+</sup> phenotype

Resende, M.; Moreira, D.; Augusto, J.; Cunha, J.; Neves, B.; Cruz, M.T.; Estaquier, J.; Cordeiro-da-Silva, A.; Silvestre, R., 2013. Journal of Immunology. 262 - 273. 1. 191. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879675210&partnerID=MN8TOARS . 10.4049/jimmunol.1203518 . Journal of Immunology

Ellagitannin-enriched fraction from Fragaria vesca leaves induces G2/M cell cycle arrest in the human hepatocellular carcinoma cell line HepG2

Liberal, J. T.; Costa, G.; Carmo, A.; Marques, C.; Cruz, M.; Batista, M., 2013. Planta Medica. 2013. https://publons.com/publon/26807099/ . 10.1055/S-0033-1352234 . Planta Medica

Prospective phospholipid markers for skin sensitization prediction in keratinocytes: A phospholipidomic approach

Santinha, D.R.; Luísa Dória, M.; Neves, B.M.; Maciel, E.A.; Martins, J.; Helguero, L.; Domingues, P.; Teresa Cruz, M.; Rosário Domingues, M., 2013. Archives of Biochemistry and Biophysics. 33 - 41. 1-2. 533. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875667120&partnerID=MN8TOARS . 10.1016/j.abb.2013.02.012 . Archives of Biochemistry and Biophysics

NO radical scavenging and iNOS expression inhibition by Cytisus multiflorus

Saraiva, S. C.; Pereira, O. R.; Liberal, J.; Batista, M. T.; Cruz, M. T.; Cardoso, S. M., 2013. European Journal of Clinical Investigation. 62 - 62. 43. 2013. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000317141000180&KeyUID=WOS:000317141000180 . European Journal of Clinical Investigation

Anti-inflammatory activity of Cymbopogon citratus leaves infusion via proteasome and nuclear factor-¿B pathway inhibition: contribution of chlorogenic acid.

Francisco V; Costa G; Figueirinha A; Marques C; Pereira P; Miguel Neves B; Celeste Lopes M; et al, 2013. 2013. http://europepmc.org/abstract/med/23583902 . 10.1016/j.jep.2013.03.077 .

Development of an in vitro dendritic cell-based test for skin sensitizer identification

Neves, B.M.; Rosa, S.C.; Martins, J.D.; Silva, A.; Goncìalo, M.; Lopes, M.C.; Cruz, M.T., 2013. Chemical Research in Toxicology. 368 - 378. 3. 26. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875168719&partnerID=MN8TOARS . 10.1021/tx300472d . Chemical Research in Toxicology

Antifungal, antioxidant and anti-inflammatory activities of Oenanthe crocata L. essential oil

Cruz, Maria Teresa, 2013. Food Chem Toxicol. 2013. 10.1016/j.fct.2013.08.083 . Food Chem Toxicol

Otanthus maritimus (L.) Hoffmanns. &amp; Link as a source of a bioactive and fragrant oil

Cabral, C.; Cavaleiro, C.; Gonçalves, M.J.; Cruz, M.T.; Lopes, M.C.; Salgueiro, L., 2013. Industrial Crops and Products. 484 - 489. 1. 43. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865287737&partnerID=MN8TOARS . 10.1016/j.indcrop.2012.07.057 . Industrial Crops and Products

Neurotensin modulates the migratory and inflammatory response of macrophages under hyperglycemic conditions

Moura, L.I.F.; Silva, L.; Leal, E.C.; Tellechea, A.; Cruz, M.T.; Carvalho, E., 2013. BioMed Research International. 2013. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884259661&partnerID=MN8TOARS . 10.1155/2013/941764 . BioMed Research International

Is exercise-in-a-bottle likely to proffer new insights into Alzheimer's disease?

Correia, S.C.; Perry, G.; Castellani, R.; Moreira, P.I., 2013. Journal of Neurochemistry. 4 - 6. 1. 127. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884846458&partnerID=MN8TOARS . 10.1111/jnc.12406 . Journal of Neurochemistry

Leptin and ghrelin prevent hippocampal dysfunction induced by Aß oligomers

Martins, I.; Gomes, S.; Costa, R.O.; Otvos, L.; Oliveira, C.R.; Resende, R.; Pereira, C.M.F., 2013. Neuroscience. 41 - 51. 241. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876430099&partnerID=MN8TOARS . 10.1016/j.neuroscience.2013.02.062 . Neuroscience

Hyperglycemia, hypoglycemia and dementia: Role of mitochondria and uncoupling proteins

Cardoso, S.; Correia, S.C.; Santos, R.X.; Carvalho, C.; Candeias, E.; Duarte, A.I.; Plácido, A.I.; Santos, M.S.; Moreira, P.I., 2013. Current Molecular Medicine. 586 - 601. 4. 13. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876735551&partnerID=MN8TOARS . 10.2174/1566524011313040010 . Current Molecular Medicine

Crosstalk between diabetes and brain: Glucagon-like peptide-1 mimetics as a promising therapy against neurodegeneration

Duarte, A.I.; Candeias, E.; Correia, S.C.; Santos, R.X.; Carvalho, C.; Cardoso, S.; Plácido, A.; et al, 2013. Biochimica et Biophysica Acta - Molecular Basis of Disease. 527 - 541. 4. 1832. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873306844&partnerID=MN8TOARS . 10.1016/j.bbadis.2013.01.008 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Insulin-induced recurrent hypoglycemia exacerbates diabetic brain mitochondrial dysfunction and oxidative imbalance

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Effect of a-Synuclein on amyloid ß-Induced toxicity: Relevance to lewy body variant of alzheimer disease

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Neurofilaments are the major neuronal target of hydroxynonenal-mediated protein cross-links

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Defective HIF signaling pathway and brain response to hypoxia in neurodegenera-tive diseases: Not an “Iffy” question!

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Hormonal control of Sertoli cell metabolism regulates spermatogenesis

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Type 2 diabetic and alzheimer's disease mice present similar behavioral, cognitive, and vascular anomalies

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Phosphorylation of tau protein as the link between oxidative stress, mitochondrial dysfunction, and connectivity failure: Implications for Alzheimer's disease

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Mitochondrial abnormalities in a streptozotocin-induced rat model of sporadic Alzheimer's disease

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Control of Sertoli cell metabolism by sex steroid hormones is mediated through modulation in glycolysis-related transporters and enzymes

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Anti-inflammatory potential of Lavandula viridis esential oil

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Antioxidant activity of polyphenol-enriched fractions from Agrimonia Eupatoria L. infusion

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Amyloid-Beta Peptide 1-42 Causes Microtubule Deregulation through N-methyl-D-aspartate Receptors in Mature Hippocampal Cultures

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Insulin signaling, glucose metabolism and mitochondria: Major players in Alzheimer's disease and diabetes interrelation

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Physical exercise as a possible strategy for brain protection: Evidence from mitochondrial-mediated mechanisms

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Nuclear and mitochondrial DNA oxidation in Alzheimer's disease

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Guidelines for the use and interpretation of assays for monitoring autophagy

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Composition and biological activity of the essential oil from Thapsia minor, a new source of geranyl acetate

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Targeting proteasome and autophagy with Fragaria Vesca L

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Immunostimulant activity of Uncaria Tomentosa and its tannins

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Lavandula luisieri essential oil as a source of antifungal drugs

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Intracellular signaling pathways modulated by phenolic compounds: Application for new anti-inflammatory drugs discovery

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Profiling changes triggered during maturation of dendritic cells: A lipidomic approach

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Insulin in central nervous system: More than just a peripheral hormone

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Amyloid-beta peptide 1-42 causes microtubule deregulation through N-methyl-D-aspartate receptors in mature hippocampal cultures

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Androgen-responsive and nonresponsive prostate cancer cells present a distinct glycolytic metabolism profile

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Alzheimer's disease and diabetes: An integrative view of the role of mitochondria, oxidative stress, and insulin

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The impairment of insulin signaling in Alzheimer's disease

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Glycogen synthase kinase 3: A point of integration in alzheimer's disease and a therapeutic target?

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Oxidative damage to RNA in aging and neurodegenerative disorders

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Mitochondrial- and endoplasmic reticulum-associated oxidative stress in Alzheimer's disease: from pathogenesis to biomarkers.

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The role of iron as a mediator of oxidative stress in Alzheimer disease

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Mitochondrial importance in Alzheimer's, Huntington's and Parkinson's diseases

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Neurofilamentopathy in neurodegenerative diseases

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Signal transduction profile of chemical sensitisers in dendritic cells: An endpoint to be included in a cell-based in vitro alternative approach to hazard identification?

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Neurotensin downregulates the pro-inflammatory properties of skin dendritic cells and increases epidermal growth factor expression

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Phytochemical and biological characterization of Agrimonia eupatoria L.: an approach to structure-activity

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Mitophagy in neurodegeneration: An opportunity for therapy?

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Modulation of Sphingosine-1-Receptors expression by LPS and contact allergen PPD

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Impact of STZ-induced hyperglycemia and insulin-induced hypoglycemia in plasma amino acids and cortical synaptosomal neurotransmitters

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An in vitro cell test for skin sensitizers prediction based on the analysis and integration of gene expression and signaling pathways activation

Neves, Bruno; Rosa, Susana; Martins, Joao; Goncalo, Margarida; Lopes, Maria Celeste; Cruz, Maria Teresa, 2011. Journal of Investigative Dermatology. S91 - S91. 131. 2011. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000294361300538&KeyUID=WOS:000294361300538 . Journal of Investigative Dermatology

Epigenetics in neurodegeneration: A new layer of complexity

Marques, S.C.F.; Oliveira, C.R.; Pereira, C.M.F.; Outeiro, T.F., 2011. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 348 - 355. 2. 35. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952900959&partnerID=MN8TOARS . 10.1016/j.pnpbp.2010.08.008 . Progress in Neuro-Psychopharmacology and Biological Psychiatry

Oxidative Stress and Balance in Neurodegenerative Diseases

Collins, G.H.; Mondragón-Rodríguez, S.; Nunomura, A.; Zhu, X.; Moreira, P.I.; Smith, M.A., 2011. Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders: Second Edition. 10 - 12. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886036204&partnerID=MN8TOARS . 10.1002/9781444341256.ch3 . Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders: Second Edition

Mitochondria control NMDA receptor-dependent calcium rise evoked by amyloid-ß 1-42 oligomers in rat cortical neurons

Ferreiro, Elisabete; Ferreira, Ildete Luisa; Cardoso, Joao M.; Pereira, Cláudia; Resende de Oliveira, Catarina; Rego, Ana Cristina Carvalho, 2011. Alzheimer's & Dementia: Journal of Alzheimer's Association. 4. 7. 2011. published Alzheimer's & Dementia: Journal of Alzheimer's Association

Using biology to untie the Gordian knot of Alzheimer's disease

Perry, G.; Smith, M.A.; Casadesus, G.; Lee, H.-G.; Moreira, P.I.; Castellani, R.J.; Zhu, X., 2011. Journal of Alzheimer's Disease. SUPPL. 1. 23. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952176838&partnerID=MN8TOARS . 10.3233/JAD-2011-001433 . Journal of Alzheimer's Disease

New insights into the mechanisms of mitochondrial preconditioning-triggered neuroprotection

Correia, S.C.; Cardoso, S.; Santos, R.X.; Carvalho, C.; Santos, M.S.; Perry, G.; Smith, M.A.; Moreira, P.I., 2011. Current Pharmaceutical Design. 3381 - 3389. 31. 17. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80055089996&partnerID=MN8TOARS . 10.2174/138161211798072490 . Current Pharmaceutical Design

Association of mitochondrial signaling in Alzheimer's disease and hypoxia

Carvalho, C.; Correia, S.C.; Santos, R.X.; Cardoso, S.; Moreira, P.I.; Zhu, X.; Smith, M.A.; Perry, G., 2011. Molecular Aspects of Neurodegeneration and Neuroprotection. 50 - 61. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884443449&partnerID=MN8TOARS . 10.2174/978160805092511101010050 . Molecular Aspects of Neurodegeneration and Neuroprotection

Amyloid-beta oligomers cause microtubule deregulation through NMDA receptors in mature hippocampal neurons

Mota, Sandra Isabel; Ferreira, Ildete Luisa; Resende de Oliveira, Catarina; Pereira, Cláudia; Rego, Ana Cristina Carvalho, 2011. Journal of Neurodegenerative Disorders. Supplement. 1. 2011. published Journal of Neurodegenerative Disorders

Effects of rapamycin and TOR on aging and memory: Implications for Alzheimer's disease

Santos, R.X.; Correia, S.C.; Cardoso, S.; Carvalho, C.; Santos, M.S.; Moreira, P.I., 2011. Journal of Neurochemistry. 927 - 936. 6. 117. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79957971392&partnerID=MN8TOARS . 10.1111/j.1471-4159.2011.07262.x . Journal of Neurochemistry

Injury markers in peripheral blood mononuclear cells from mild cognitive impairment and Alzheimer’s disease patients

Ferreira, Ildete Luisa; Mota, Sandra Isabel; Costa, Rui Miguel Oliveira da; Padovano, C; Fonseca, Ana Catarina Ribeiro da Graça; Letra, Liliana; Resende de Oliveira, Catarina; et al, 2011. Journal of Neurodegenerative Diseases. Supplement. 1. 2011. published Journal of Neurodegenerative Diseases

Mitochondria from distinct tissues are differently affected by 17ß-estradiol and tamoxifen

Moreira, P.I.; Custódio, J.B.A.; Nunes, E.; Oliveira, P.J.; Moreno, A.; Seia, R.; Oliveira, C.R.; Santos, M.S., 2011. Journal of Steroid Biochemistry and Molecular Biology. 8 - 16. 1-2. 123. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650578395&partnerID=MN8TOARS . 10.1016/j.jsbmb.2010.09.004 . Journal of Steroid Biochemistry and Molecular Biology

SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1a Destabilization

Finley, L.; Carracedo, A.; Lee, J.; Souza, A.; Egia, A.; Zhang, J.; Teruya-Feldstein, J.; et al, 2011. Cancer Cell. 416 - 428. 3. 19. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952501323&partnerID=MN8TOARS . 10.1016/j.ccr.2011.02.014 . Cancer Cell

Mitochondria as potential targets in antidiabetic therapy

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Cymbopogon citratus as source of new and safe anti-inflammatory drugs: Bio-guided assay using lipopolysaccharide-stimulated macrophages

Francisco, Vera; Figueirinha, Artur; Neves, Bruno Miguel; García-Rodríguez, Carmen; Lopes, Maria Celeste; Cruz, Maria Teresa; Batista, Maria Teresa; et al, 2011. Journal of Ethnopharmacology. 818 - 827. 2. 133. 2011. http://hdl.handle.net/10316/18004 . 10.1016/j.jep.2010.11.018 . Journal of Ethnopharmacology

Anti-inflammatory activity of cymbopogon citratus leaf infusion in lipopolysaccharide-stimulated dendritic cells: Contribution of the polyphenols

Figueirinha, A.; Cruz, M.T.; Francisco, V.; Lopes, M.C.; Batista, M.T., 2010. Journal of Medicinal Food. 681 - 690. 3. 13. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953730391&partnerID=MN8TOARS . 10.1089/jmf.2009.0115 . Journal of Medicinal Food

Effect of lipopolysaccharide, skin sensitizers and irritants on thioredoxin-1 expression in dendritic cells: Relevance of different signalling pathways

Francisco, V.; Neves, B.M.; Cruz, M.T.; Gonçalo, M.; Figueiredo, A.; Duarte, C.B.; Lopes, M.C., 2010. Archives of Dermatological Research. 271 - 282. 4. 302. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952180893&partnerID=MN8TOARS . 10.1007/s00403-009-0993-z . Archives of Dermatological Research

CXCL12/CXCR4 promotes motility and proliferation of glioma cells

do Carmo, Analia; Patricio, Ines; Cruz, Maria T.; Carvalheiro, Helena; Oliveira, Catarina R.; Lopes, Maria C.; do Carmo A; et al, 2010. Cancer Biology & Therapy. 56 - 65. 1. 9. 2010. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000274578800011&KeyUID=WOS:000274578800011 . 10.4161/cbt.9.1.10342 . Cancer Biology & Therapy

Autophagy in Alzheimers disease

Moreira, P.I.; Santos, R.X.; Zhu, X.; Lee, H.-G.; Smith, M.A.; Casadesus, G.; Perry, G., 2010. Expert Review of Neurotherapeutics. 1209 - 1218. 7. 10. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954196784&partnerID=MN8TOARS . 10.1586/ern.10.84 . Expert Review of Neurotherapeutics

Activation of phosphatidylinositol 3-kinase/akt and impairment of nuclear factor-¿B: Molecular mechanisms behind the arrested maturation/activation state of leishmania infantum-infected dendritic cells

Neves, B.M.; Silvestre, R.; Resende, M.; Ouaissi, A.; Cunha, J.; Tavares, J.; Loureiro, I.; et al, 2010. American Journal of Pathology. 2898 - 2911. 6. 177. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650195216&partnerID=MN8TOARS . 10.2353/ajpath.2010.100367 . American Journal of Pathology

Chemical, antifungal and cytotoxic evaluation of the essential oil of Thymus zygis subsp. sylvestris

Gonçalves, M.J.; Cruz, M.T.; Cavaleiro, C.; Lopes, M.C.; Salgueiro, L., 2010. Industrial Crops and Products. 70 - 75. 1. 32. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954864678&partnerID=MN8TOARS . 10.1016/j.indcrop.2010.03.005 . Industrial Crops and Products

Cholesterol and statins in Alzheimer's disease: Current controversies

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ROLE OF GLYCOGEN SYNTHASE KINASE-3B ON TAU PHOSPHORYLATION IN ALZHEIMER'S DISEASE

Resende, Rosa; Oliveira, Catarina Resende; Pereira, Claudia M. F., 2010. Advances in Medicine and Biology, Vol 2. 197 - 210. 2. 2010. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000278696200007&KeyUID=WOS:000278696200007 . Advances in Medicine and Biology, Vol 2

Role of neuropeptides in skin inflammation and its involvement in diabetic wound healing

Da Silva, L.; Carvalho, E.; Cruz, M.T., 2010. Expert Opinion on Biological Therapy. 1427 - 1439. 10. 10. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956664657&partnerID=MN8TOARS . 10.1517/14712598.2010.515207 . Expert Opinion on Biological Therapy

Multiple Defects in Energy Metabolism in Alzheimer's Disease

Ferreira, I. L.; Resende, R.; Ferreiro, E.; Rego, A. C.; Pereira, C. F., 2010. Current Drug Targets. 1193 - 1206. 10. 11. 2010. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000285183900002&KeyUID=WOS:000285183900002 . Current Drug Targets

Epigenetics and Neurodegeneration: A Connection Overlooked

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Alzheimer's disease: The quest to understand complexity

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Essential oils from Distichoselinum tenuifolium: Chemical composition, cytotoxicity, antifungal and anti-inflammatory properties

Tavares, A.C.; Gonçalves, M.J.; Cruz, M.T.; Cavaleiro, C.; Lopes, M.C.; Canhoto, J.; Salgueiro, L.R.; et al, 2010. Journal of Ethnopharmacology. 593 - 598. 3. 130. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954954559&partnerID=MN8TOARS . 10.1016/j.jep.2010.05.054 . Journal of Ethnopharmacology

Targeting autophagy in the brain: A promising approach?

Santos, R.X.; Cardoso, S.; Correia, S.; Carvalho, C.; Santos, M.S.; Moreira, P.I., 2010. Central Nervous System Agents in Medicinal Chemistry. 158 - 168. 2. 10. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953681716&partnerID=MN8TOARS . Central Nervous System Agents in Medicinal Chemistry

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Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology

Moreira, P.I.; Carvalho, C.; Zhu, X.; Smith, M.A.; Perry, G., 2010. Biochimica et Biophysica Acta - Molecular Basis of Disease. 2 - 10. 1. 1802. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-71749121998&partnerID=MN8TOARS . 10.1016/j.bbadis.2009.10.006 . Biochimica et Biophysica Acta - Molecular Basis of Disease

A synergistic dysfunction of mitochondrial fission/fusion dynamics and mitophagy in Alzheimer's disease

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Detection and localization of markers of oxidative stress by in situ methods: application in the study of Alzheimer disease.

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Chronic hypoxia potentiates age-related oxidative imbalance in brain vessels and synaptosomes

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Hypoxia-inducible factor 1: A new hope to counteract neurodegeneration?

Correia, S.C.; Moreira, P.I., 2010. Journal of Neurochemistry. 1 - 12. 1. 112. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-71649085107&partnerID=MN8TOARS . 10.1111/j.1471-4159.2009.06443.x . Journal of Neurochemistry

Polyphenols from Cymbopogon citratus inhibit iNOS expression and NO production - a promising source of new anti-inflammatory drugs

Francisco, V; Figueirinha, A.; Neves, B.; Garcia-Rodriguez, C.; Lopes, M.; Cruz, M.; Batista, M., 2010. Planta Medica. 2010. https://publons.com/publon/21604165/ . Planta Medica

Effects of estrogen in the brain: Is it a neuroprotective agent in alzheimer's disease?

Correia, S.C.; Santos, R.X.; Cardoso, S.; Carvalho, C.; Santos, M.S.; Oliveira, C.R.; Moreira, P.I., 2010. Current Aging Science. 113 - 126. 2. 3. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953736213&partnerID=MN8TOARS . 10.2174/1874609811003020113 . Current Aging Science

Cortical and hippocampal mitochondria bioenergetics and oxidative status during hyperglycemia and/or insulin-induced hypoglycemia

Cardoso, S.; Santos, M.S.; Seiça, R.; Moreira, P.I., 2010. Biochimica et Biophysica Acta - Molecular Basis of Disease. 942 - 951. 11. 1802. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956710094&partnerID=MN8TOARS . 10.1016/j.bbadis.2010.07.001 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Mitochondria: The missing link between preconditioning and neuroprotection

Correia, S.C.; Santos, R.X.; Perry, G.; Zhu, X.; Moreira, P.I.; Smith, M.A., 2010. Journal of Alzheimer's Disease. SUPPL.2. 20. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956220265&partnerID=MN8TOARS . 10.3233/JAD-2010-100669 . Journal of Alzheimer's Disease

Alzheimer's disease: Diverse aspects of mitochondrial malfunctioning

Santos, R.X.; Correia, S.C.; Wang, X.; Perry, G.; Smith, M.A.; Moreira, P.I.; Zhu, X., 2010. International Journal of Clinical and Experimental Pathology. 570 - 581. 6. 3. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956026971&partnerID=MN8TOARS . International Journal of Clinical and Experimental Pathology

ER stress-mediated apoptotic pathway induced by aß peptide requires the presence of functional mitochondria

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Alzheimer's Disease: An Overview

Moreira, P.I.; Zhu, X.; Smith, M.A.; Perry, G., 2010. Encyclopedia of Neuroscience. 259 - 263. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-84882903387&partnerID=MN8TOARS . 10.1016/B978-008045046-9.00544-1 . Encyclopedia of Neuroscience

Mitochondrial control of autophagic lysosomal pathway in Alzheimer's disease

Cardoso, S.M.; Pereira, C.F.; Moreira, P.I.; Arduino, D.M.; Esteves, A.R.; Oliveira, C.R., 2010. Experimental Neurology. 294 - 298. 2. 223. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952549554&partnerID=MN8TOARS . 10.1016/j.expneurol.2009.06.008 . Experimental Neurology

Potential antioxidant and anti-inflammatory properties in Teucrium salviastrum Schreb

Cabral, C.; Francisco, V; Cruz, M.; Lopes, M.; Salgueiro, L.; Sales, F.; Batista, M., 2010. Planta Medica. 2010. https://publons.com/publon/7273471/ . 10.1055/S-0030-1264535 . Planta Medica

Mitochondrial preconditioning: A potential neuroprotective strategy

Correia, S.C.; Carvalho, C.; Cardoso, S.; Santos, R.X.; Santos, M.S.; Oliveira, C.R.; Perry, G.; et al, 2010. Frontiers in Aging Neuroscience. AUG. 2. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955962818&partnerID=MN8TOARS . 10.3389/fnagi.2010.00138 . Frontiers in Aging Neuroscience

Mitochondria: A therapeutic target in neurodegeneration

Moreira, P.I.; Zhu, X.; Wang, X.; Lee, H.-g.; Nunomura, A.; Petersen, R.B.; Perry, G.; Smith, M.A., 2010. Biochimica et Biophysica Acta - Molecular Basis of Disease. 212 - 220. 1. 1802. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-71849088759&partnerID=MN8TOARS . 10.1016/j.bbadis.2009.10.007 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Mitochondria as a therapeutic target in Alzheimer's disease and diabetes

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CXCL12/CXCR4 MODULATES GLIOMA CELL SURVIVAL AND MOTILITY

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Differential roles of PI3-Kinase, MAPKs and NF-¿B on the manipulation of dendritic cell T<inf>h</inf>1/T<inf>h</inf>2 cytokine/chemokine polarizing profile

Neves, B.M.; Cruz, M.T.; Francisco, V.; Garcia-Rodriguez, C.; Silvestre, R.; Cordeiro-da-Silva, A.; Dinis, A.M.; et al, 2009. Molecular Immunology. 2481 - 2492. 13. 46. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-67650397827&partnerID=MN8TOARS . 10.1016/j.molimm.2009.05.021 . Molecular Immunology

RNA oxidation in Alzheimer disease and related neurodegenerative disorders

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Mitochondria as a therapeutic target in Alzheimer's disease and diabetes

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Altered redox balance in disease: Can we change the new equilibria?

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Doxorubicin: The good, the bad and the ugly effect

Carvalho, C.; Santos, R.X.; Cardoso, S.; Correia, S.; Oliveira, P.J.; Santos, M.S.; Moreira, P.I., 2009. Current Medicinal Chemistry. 3267 - 3285. 25. 16. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-70450215499&partnerID=MN8TOARS . 10.2174/092986709788803312 . Current Medicinal Chemistry

Neuroprotective effects of statins in an in vitro model of alzheimer's disease

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Communication between endoplamic reticulum and mitochondria in the neuronal death induced by amyloid-beta peptide

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Insulin is a two-edged knife on the brain

Cardoso, S.; Correia, S.; Santos, R.X.; Carvalho, C.; Santos, M.S.; Oliveira, C.R.; Perry, G.; et al, 2009. Journal of Alzheimer's Disease. 483 - 507. 3. 18. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-75249106915&partnerID=MN8TOARS . Journal of Alzheimer's Disease

Therapeutic opportunities in Alzheimer disease: Current concepts

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Statins prevent beta-amyloid-induced toxicity in cortical neurons

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An integrative view of the role of oxidative stress, mitochondria and insulin in Alzheimer's disease

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Natural oxidant balance in Parkinson disease

Perry, G.; Moreira, P.I.; Siedlak, S.L.; Nunomura, A.; Zhu, X.; Smith, M.A., 2009. Archives of Neurology. 12. 66. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-73549092919&partnerID=MN8TOARS . 10.1001/archneurol.2009.261 . Archives of Neurology

Inhibition of LPS-induced nuclear factor NF-kappa B activation by Cymbopogon citratus leaves in macrophages: a strategy to develop new anti-inflammatory drugs

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Role of mitochondrial-mediated signaling pathways in Alzheimer disease and hypoxia

Carvalho, C.; Correia, S.C.; Santos, R.X.; Cardoso, S.; Moreira, P.I.; Clark, T.A.; Zhu, X.; Smith, M.A.; Perry, G., 2009. Journal of Bioenergetics and Biomembranes. 433 - 440. 5. 41. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-70449397210&partnerID=MN8TOARS . 10.1007/s10863-009-9247-1 . Journal of Bioenergetics and Biomembranes

Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease

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Metformin promotes isolated rat liver mitochondria impairment

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Neurotoxic effect of oligomeric and fibrillar species of amyloid-beta peptide 1-42: Involvement of endoplasmic reticulum calcium release in oligomer-induced cell death

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ER stress is involved in Aß-induced GSK-3ß activation and tau phosphorylation

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Alzheimer disease and the role of free radicals in the pathogenesis of the disease

Moreira, P.I.; Santos, M.S.; Oliveira, C.R.; Shenk, J.C.; Nunomura, A.; Smith, M.A.; Zhu, X.; Perry, G., 2008. CNS and Neurological Disorders - Drug Targets. 3 - 10. 1. 7. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-42049116923&partnerID=MN8TOARS . 10.2174/187152708783885156 . CNS and Neurological Disorders - Drug Targets

Sublethal RNA oxidation as a mechanism for neurodegenerative disease

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Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

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Oxidative stress signaling in Alzheimer's disease

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Differential modulation of CXCR4 and CD40 protein levels by skin sensitizers and irritants in the FSDC cell line

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Amyloid-ß overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

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Cross-talk between endoplasmic reticulum and mitochondria in the neurotoxicity induced by Alzheimer's disease–associated beta-amyloid peptide

Pereira, Cláudia; Ferreiro, Elisabete; Costa, Rui Miguel Oliveira da; Resende, Rosa; Morais Cardoso, Sandra; Resende de Oliveira, Catarina, 2008. Alzheimer’s and Dementia . T345 - T345. 4. 4. 2008. published Alzheimer’s and Dementia

Antioxidant therapy in Alzheimer's disease: theory and practice.

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Doxorubicin increases the susceptibility of brain mitochondria to Ca2+-induced permeability transition and oxidative damage

Cardoso, S.; Santos, R.X.; Carvalho, C.; Correia, S.; Pereira, G.C.; Pereira, S.S.; Oliveira, P.J.; et al, 2008. Free Radical Biology and Medicine. 1395 - 1402. 10. 45. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-54349099428&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2008.08.008 . Free Radical Biology and Medicine

Essential oil of Daucus carota subsp. halophilus: Composition, antifungal activity and cytotoxicity

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Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease

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Nucleic acid oxidation in Alzheimer disease

Moreira, P.I.; Nunomura, A.; Nakamura, M.; Takeda, A.; Shenk, J.C.; Aliev, G.; Smith, M.A.; Perry, G., 2008. Free Radical Biology and Medicine. 1493 - 1505. 8. 44. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-41149166082&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2008.01.002 . Free Radical Biology and Medicine

The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway

Ferreiro, E.; Oliveira, C.R.; Pereira, C.M.F., 2008. Neurobiology of Disease. 331 - 342. 3. 30. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-43649083316&partnerID=MN8TOARS . 10.1016/j.nbd.2008.02.003 . Neurobiology of Disease

Mechanisms of action of metformin in type 2 diabetes and associated complications: an overview.

Correia, S.; Carvalho, C.; Santos, M.S.; Seiça, R.; Oliveira, C.R.; Moreira, P.I., 2008. Mini reviews in medicinal chemistry. 1343 - 1354. 13. 8. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-58149377770&partnerID=MN8TOARS . 10.2174/138955708786369546 . Mini reviews in medicinal chemistry

Involvement of mitochondria in endoplasmic reticulum stress-induced apoptotic cell death pathway triggered by the prion peptide PrP 106-126

Ferreiro, E.; Costa, R.; Marques, S.; Cardoso, S.M.; Oliveira, C.R.; Pereira, C.M.F., 2008. Journal of Neurochemistry. 766 - 776. 3. 104. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-38049162500&partnerID=MN8TOARS . 10.1111/j.1471-4159.2007.05048.x . Journal of Neurochemistry

CXCR4 expression mediates the survival and proliferation of glioma cells

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Metformin protects the brain against the oxidative imbalance promoted by type 2 diabetes

Correia, S.; Carvalho, C.; Santos, M.S.; Proença, T.; Nunes, E.; Duarte, A.I.; Monteiro, P.; et al, 2008. Medicinal Chemistry. 358 - 364. 4. 4. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-50049125341&partnerID=MN8TOARS . 10.2174/157340608784872299 . Medicinal Chemistry

Oxidative RNA damage and neurodegeneration

Nunomura, A.; Moreira, P.I.; Takeda, A.; Smith, M.A.; Perry, G., 2007. Current Medicinal Chemistry. 2968 - 2975. 28. 14. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-36849076772&partnerID=MN8TOARS . 10.2174/092986707782794078 . Current Medicinal Chemistry

Bcl-2 overexpression protects against amyloid-beta and prion toxicity in GT1-7 neural cells

Ferreiro, Elisabete; Eufrasio, Ana; Pereira, Claudia; Oliveira, Catarina R.; Rego, A. Cristina; Ferreiro, E.; Eufrásio, A.; et al, 2007. Journal of Alzheimers Disease. 223 - 228. 3. 12. 2007. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000252300000003&KeyUID=WOS:000252300000003 . Journal of Alzheimers Disease

Alzheimer's disease: A lesson from mitochondrial dysfunction

Moreira, P.I.; Santos, M.S.; Oliveira, C.R., 2007. Antioxidants and Redox Signaling. 1621 - 1630. 10. 9. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34648831384&partnerID=MN8TOARS . 10.1089/ars.2007.1703 . Antioxidants and Redox Signaling

Neurodegeneration in Alzheimer's disease: Inter-organelle cross-talk and oxidative stress in cell life and death decisions

Ferreiro, Elisabete; Resende, Rosa; Costa, Rui Miguel Oliveira da; Moreira, Paula Isabel; Morais Cardoso, Sandra; Pereira, Cláudia; Resende de Oliveira, Catarina; et al, 2007. Free Radical Research. S11 - S11. 41. 2007. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000252296300021&KeyUID=WOS:000252296300021 . Free Radical Research

Iron: The redox-active center of oxidative stress in Alzheimer disease

Castellani, R.J.; Moreira, P.I.; Liu, G.; Dobson, J.; Perry, G.; Smith, M.A.; Zhu, X., 2007. Neurochemical Research. 1640 - 1645. 10. 32. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548744723&partnerID=MN8TOARS . 10.1007/s11064-007-9360-7 . Neurochemical Research

Does mitochondria impairment affect endoplasmic reticulum function during amyloid-beta toxicity?

Costa, R.; Ferreiro, E.; Oliveira, C. R.; Pereira, C.; Costa, Rui Miguel Oliveira da; Ferreiro, Elisabete; Resende de Oliveira, Catarina; Pereira, Cláudia, 2007. Journal of Neurochemistry. 68 - 69. Supplement. 102. 2007. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000248991600162&KeyUID=WOS:000248991600162 . published Journal of Neurochemistry

Lipoic acid and N-acetyl cysteine decrease mitochondrial-related oxidative stress in Alzheimer disease patient fibroblasts

Moreira, P.I.; Harris, P.L.R.; Zhu, X.; Santos, M.S.; Oliveira, C.R.; Smith, M.A.; Perry, G., 2007. Journal of Alzheimer's Disease. 195 - 206. 2. 12. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34848890388&partnerID=MN8TOARS . Journal of Alzheimer's Disease

Neuropathology and treatment of Alzheimer disease: Did we lose the forest for the trees?

Castellani, R.J.; Zhu, X.; Lee, H.-G.; Moreira, P.I.; Perry, G.; Smith, M.A., 2007. Expert Review of Neurotherapeutics. 473 - 485. 5. 7. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34248326079&partnerID=MN8TOARS . 10.1586/14737175.7.5.473 . Expert Review of Neurotherapeutics

Estradiol affects liver mitochondrial function in ovariectomized and tamoxifen-treated ovariectomized female rats

Moreira, P.I.; Custódio, J.B.A.; Nunes, E.; Moreno, A.; Seiça, R.; Oliveira, C.R.; Santos, M.S., 2007. Toxicology and Applied Pharmacology. 102 - 110. 1. 221. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34247869542&partnerID=MN8TOARS . 10.1016/j.taap.2007.02.006 . Toxicology and Applied Pharmacology

Effect of skin sensitizers on inducible nitric oxide synthase expression and nitric oxide production in skin dendritic cells: Role of different immunosuppressive drugs

Cruz, M.T.; Neves, B.M.; Gonçalo, M.; Figueiredo, A.; Duarte, C.B.; Lopes, M.C., 2007. Immunopharmacology and Immunotoxicology. 225 - 241. 2. 29. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548553284&partnerID=MN8TOARS . 10.1080/08923970701512304 . Immunopharmacology and Immunotoxicology

Differential CXCR4 expression induced by skin sensitizers or irritants in dendritic cell models

Neves, B.; Cruz, M. T.; Goncalo, M.; Figueiredo, A.; Duarte, C. B.; Lopes, M. C., 2007. Journal of Investigative Dermatology. S5 - S5. 127. 2007. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000249933400026&KeyUID=WOS:000249933400026 . Journal of Investigative Dermatology

Indices of metabolic dysfunction and oxidative stress

Casadesus, G.; Moreira, P.I.; Nunomura, A.; Siedlak, S.L.; Bligh-Glover, W.; Balraj, E.; Petot, G.; Smith, M.A.; Perry, G., 2007. Neurochemical Research. 717 - 722. 4-5. 32. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947593456&partnerID=MN8TOARS . 10.1007/s11064-007-9296-y . Neurochemical Research

Erratum: Increased autophagic degradation of mitochondria in Alzheimer disease (Autophagy)

Moreira, P.I.; Siedlak, S.L.; Wang, X.; Santos, M.S.; Oliveira, C.R.; Tabaton, M.; Nunomura, A.; et al, 2007. Autophagy. 614 - 615. 6. 3. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-35848931249&partnerID=MN8TOARS . Autophagy

Soybean oil treatment impairs glucose-stimulated insulin secretion and changes fatty acid composition of normal and diabetic islets

Nunes, E.; Peixoto, F.; Louro, T.; Sena, C.M.; Santos, M.S.; Matafome, P.; Moreira, P.I.; Seiça, R., 2007. Acta Diabetologica. 121 - 130. 3. 44. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548177719&partnerID=MN8TOARS . 10.1007/s00592-007-0252-8 . Acta Diabetologica

Vascular oxidative stress in Alzheimer disease

Zhu, X.; Smith, M.A.; Honda, K.; Aliev, G.; Moreira, P.I.; Nunomura, A.; Casadesus, G.; et al, 2007. Journal of the Neurological Sciences. 240 - 246. 1-2. 257. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34249776958&partnerID=MN8TOARS . 10.1016/j.jns.2007.01.039 . Journal of the Neurological Sciences

Autophagocytosis of mitochondria is prominent in Alzheimer disease

Moreira, P.I.; Siedlak, S.L.; Wang, X.; Santos, M.S.; Oliveira, C.R.; Tabaton, M.; Nunomura, A.; et al, 2007. Journal of Neuropathology and Experimental Neurology. 525 - 532. 6. 66. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34249881080&partnerID=MN8TOARS . 10.1097/01.jnen.0000240476.73532.b0 . Journal of Neuropathology and Experimental Neurology

Erratum: Autophagocytosis of mitochondria is prominent in Alzheimer disease (Journal of Neuropathology and Experimental Neurology (2007) 66, (525-532))

Moreira, P.I.; Siedlak, S.L.; Wang, X.; Santos, M.S.; Oliveira, C.R.; Tabaton, M.; Nunomura, A.; et al, 2007. Journal of Neuropathology and Experimental Neurology. 7. 66. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34447321588&partnerID=MN8TOARS . 10.1097/01.jnen.0000263876.99435.cb . Journal of Neuropathology and Experimental Neurology

The key role of oxidative stress in alzheimer's disease

Moreira, P.I.; Nunomura, A.; Honda, K.; Aliev, G.; Casadesus, G.; Zhu, X.; Smith, M.A.; Perry, G., 2007. Oxidative Stress and Neurodegenerative Disorders. 267 - 281. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-84882487316&partnerID=MN8TOARS . 10.1016/B978-044452809-4/50153-8 . Oxidative Stress and Neurodegenerative Disorders

Neuronal death and survival under oxidative stress in Alzheimer and Parkinson diseases

Nunomura, A.; Moreira, P.I.; Lee, H.G.; Zhu, X.; Castellani, R.J.; Smith, M.A.; Perry, G., 2007. CNS and Neurological Disorders - Drug Targets. 411 - 423. 6. 6. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-41749088686&partnerID=MN8TOARS . 10.2174/187152707783399201 . CNS and Neurological Disorders - Drug Targets

Brain mitochondrial dysfunction as a link between Alzheimer's disease and diabetes

Moreira, P.I.; Santos, M.S.; Seiça, R.; Oliveira, C.R., 2007. Journal of the Neurological Sciences. 206 - 214. 1-2. 257. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34249821079&partnerID=MN8TOARS . 10.1016/j.jns.2007.01.017 . Journal of the Neurological Sciences

Susceptibility of hippocampal neurons to Aß peptide toxicity is associated with perturbation of Ca2+ homeostasis

Resende, R.; Pereira, C.; Agostinho, P.; Vieira, A.P.; Malva, J.O.; Oliveira, C.R., 2007. Brain Research. 11 - 21. 1. 1143. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947303240&partnerID=MN8TOARS . 10.1016/j.brainres.2007.01.071 . Brain Research

Prevention and treatment of Alzheimer disease and aging: Antioxidants

Liu, Q.; Xie, F.; Rolston, R.; Moreira, P.I.; Nunomura, A.; Zhu, X.; Smith, M.A.; Perry, G., 2007. Mini-Reviews in Medicinal Chemistry. 171 - 180. 2. 7. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-33847776693&partnerID=MN8TOARS . 10.2174/138955707779802552 . Mini-Reviews in Medicinal Chemistry

Neuropathology in Alzheimer's disease: awaking from a hundred-year-old dream.

Nunomura, A.; Castellani, R.J.; Lee, H.G.; Moreira, P.I.; Zhu, X.; Perry, G.; Smith, M.A., 2006. Science of aging knowledge environment : SAGE KE. 8. 2006. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33744531637&partnerID=MN8TOARS . 10.1126/sageke.2006.8.pe10 . Science of aging knowledge environment : SAGE KE

Foreword: Mitochondria in Alzheimer disease

Moreira, P.I.; Oliveira, C., 2006. Journal of Alzheimer's Disease. 2. 9. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33746065622&partnerID=MN8TOARS . Journal of Alzheimer's Disease

Mitochondrial abnormalities and oxidative imbalance in Alzheimer disease

Zhu, X.; Perry, G.; Moreira, P.I.; Aliev, G.; Cash, A.D.; Hirai, K.; Smith, M.A., 2006. Journal of Alzheimer's Disease. 147 - 153. 2. 9. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33746089859&partnerID=MN8TOARS . Journal of Alzheimer's Disease

Presenilin mutation: A deadly first hit in Alzheimer disease - A commentary on "aging sensitizes towards ROS formation and lipid peroxidation in PS1M146L transgenic mice"

Zhu, X.; Lee, H.-G.; Moreira, P.I.; Smith, M.A.; Perry, G., 2006. Free Radical Biology and Medicine. 737 - 739. 5. 40. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644659794&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2005.12.028 . Free Radical Biology and Medicine

Tamoxifen and estradiol interact with the flavin mononucleotide site of complex I leading to mitochondrial failure

Moreira, P.I.; Custódio, J.; Moreno, A.; Oliveira, C.R.; Santos, M.S., 2006. Journal of Biological Chemistry. 10143 - 10152. 15. 281. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33744518169&partnerID=MN8TOARS . 10.1074/jbc.M510249200 . Journal of Biological Chemistry

Insulin attenuates diabetes-related mitochondrial alterations: A comparative study

Moreira, P.I.; Rolo, A.P.; Sena, C.; Seiça, R.; Oliveira, C.R.; Santos, M.S., 2006. Medicinal Chemistry. 299 - 308. 3. 2. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33746153746&partnerID=MN8TOARS . 10.2174/157340606776930754 . Medicinal Chemistry

Telomeres and telomerase in Alzheimer's disease: Epiphenomena or a new focus for therapeutic strategy?

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Therapeutic options in Alzheimer's disease

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The key role of mitochondria in Alzheimer's disease

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Brain and brawn: Parallels in oxidative strength

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Insulin protects against amyloid ß-peptide toxicity in brain mitochondria of diabetic rats

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Therapeutic opportunities in Alzheimer Disease: One for all or all for one?

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Brain mitochondrial injury induced by oxidative stress-related events is prevented by tamoxifen

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Mitogen- and stress-activated protein kinase 1: Convergence of the ERK and p38 pathways in Alzheimer's disease

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Tau phosphorylation in Alzheimer's disease: Pathogen or protector?

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CoQ10 therapy attenuates amyloid ß-peptide toxicity in brain mitochondria isolated from aged diabetic rats

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Hydroxytamoxifen protects against oxidative stress in brain mitochondria

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The Sensitizers Nickel Sulfate and 2,4-dinitrofluorobenzene Increase CD40 and IL-12 Receptor Expression in a Fetal Skin Dendritic Cell Line

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Neurofilament proteins in neurodegenerative diseases

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The Sensitizer 2,4-Dinitrofluorobenzene Activates Caspase-3 and Induces Cell Death in a Skin Dendritic Cell Line

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Increased vulnerability of brain mitochondria in diabetic (goto-kakizaki) rats with aging and amyloid-ß exposure

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Dexamethasone prevents granulocyte-macrophage colony-stimulating factor-induced nuclear factor-¿B activation, inducible nitric oxide synthase expression and nitric oxide production in a skin dendritic cell line

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Cruz, M.T.; Duarte, C.B.; Gonçalo, M.; Carvalho, A.P.; Lopes, M.C., 2001. Nitric Oxide - Biology and Chemistry. 53 - 61. 1. 5. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035708551&partnerID=MN8TOARS . 10.1006/niox.2000.0320 . Nitric Oxide - Biology and Chemistry

Granulocyte-macrophage colony-stimulating factor activates the transcription of nuclear factor kappa B and induces the expression of nitric oxide synthase in a skin dendritic cell line

Cruz, M.T.; Duarte, C.B.; Gonçalo, M.; Figueiredo, A.; Carvalho, A.P.; Lopes, M.C., 2001. Immunology and Cell Biology. 590 - 596. 6. 79. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035176476&partnerID=MN8TOARS . 10.1046/j.1440-1711.2001.01041.x . Immunology and Cell Biology

Effect of zinc ions on the cytotoxicity induced by the amyloid ß- peptide

Moreira, P.; Pereira, C.; Santos, M.S.; Oliveira, C., 2000. Antioxidants and Redox Signaling. 317 - 325. 2. 2. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033949740&partnerID=MN8TOARS . Antioxidants and Redox Signaling

Susceptibility to ß-amyloid-induced toxicity is decreased in Goto- Kakizaki diabetic rats: Involvement of oxidative stress

Pereira, C.; Moreira, P.; Seiça, R.; Santos, M.S.; Oliveira, C.R., 2000. Experimental Neurology. 383 - 391. 1. 161. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034051172&partnerID=MN8TOARS . 10.1006/exnr.1999.7270 . Experimental Neurology

Effect of zinc ions on the cytotoxicity induced by the amyloid ß- peptide

Moreira, P.; Pereira, C.; Santos, M.S.; Oliveira, C., 2000. Antioxidants and Redox Signaling. 317 - 325. 2. 2. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033949740&partnerID=MN8TOARS . Antioxidants and Redox Signaling

Oxidative glutamate toxicity involves mitochondrial dysfunction and perturbation of intracellular Ca2+ homeostasis

Pereira, CF; de Oliveira, CR, 2000. Neuroscience Research. 227 - 236. 3. 37. 2000. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000088427400008&KeyUID=WOS:000088427400008 . 10.1016/S0168-0102(00)00124-3 . Neuroscience Research

Synaptosomal response to oxidative stress: Effect of vinpocetine

Santos, M.S.; Duarte, A.I.; Moreira, P.I.; Oliveira, C.R., 2000. Free Radical Research. 57 - 66. 1. 32. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033988559&partnerID=MN8TOARS . Free Radical Research

Effect of Zinc Ions on the Cytotoxicity Induced by the Amyloid beta-Peptide

Moreira, Paula; Pereira, Claudia; Santos, Maria S.; Oliveira, Catarina, 2000. Antioxidants & Redox Signaling. 317 - 325. 2. 2. 2000. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000207500700014&KeyUID=WOS:000207500700014 . 10.1089/ars.2000.2.2-317 . Antioxidants & Redox Signaling

Susceptibility to ß-amyloid-induced toxicity is decreased in Goto- Kakizaki diabetic rats: Involvement of oxidative stress

Pereira, C.; Moreira, P.; Seiça, R.; Santos, M.S.; Oliveira, C.R., 2000. Experimental Neurology. 383 - 391. 1. 161. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034051172&partnerID=MN8TOARS . 10.1006/exnr.1999.7270 . Experimental Neurology

Vinpocetine attenuates the metabolic dysfunction induced by amyloid beta-peptides in PC12 cells

Pereira, C; Agostinho, P; Oliveira, CR; Pereira, C.; Agostinho, P.; Oliveira, C.R., 2000. Free Radical Research. 497 - 506. 5. 33. 2000. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000166441800006&KeyUID=WOS:000166441800006 . 10.1080/10715760000301041 . Free Radical Research

Involvement of oxidative stress on the impairment of energy metabolism induced by Aß peptides on PC12 cells: Protection by antioxidants

Pereira, C.; Santos, M.S.; Oliveira, C., 1999. Neurobiology of Disease. 209 - 219. 3. 6. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033022771&partnerID=MN8TOARS . 10.1006/nbdi.1999.0241 . Neurobiology of Disease

Involvement of JAK2 and MAPK on type II nitric oxide synthase expression in skin-derived dendritic cells

Cruz, M.T.; Duarte, C.B.; Gonçalo, M.; Carvalho, A.P.; Lopes, M.G.; Cruz, M. T.; Duarte, C. B.; et al, 1999. American Journal of Physiology - Cell Physiology. C1050 - C1057. 6 46-6. 277. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033373205&partnerID=MN8TOARS . 10.1152/AJPCELL.1999.277.6.C1050 . American Journal of Physiology - Cell Physiology

Mitochondrial function is differentially affected upon oxidative stress

Cardoso, S.M.; Pereira, C.; Oliveira, C.R., 1999. Free Radical Biology and Medicine. 3 - 13. 1-2. 26. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0345222531&partnerID=MN8TOARS . 10.1016/S0891-5849(98)00205-6 . Free Radical Biology and Medicine

Photosensitization of lymphoblastoid cells with phthalocyanines at different saturating incubation times

Gomes, E. R.; Cruz, T.; Lopes, C. F.; Carvalho, A. P.; Duarte, C. B.; Gomes, E.R.; Lopes, C.F.; Carvalho, A.P.; Duarte, C.B., 1999. Cell Biology and Toxicology. 249 - 260. 4. 15. 1999. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000084642800005&KeyUID=WOS:000084642800005 . 10.1023/a:1007615813184 . Cell Biology and Toxicology

Calcium-dependent nitric oxide synthase activity in rat thymocytes

Cruz, M.T.; Carmo, A.; Carvalho, A.P.; Lopes, M.C., 1998. Biochemical and Biophysical Research Communications. 98 - 103. 1. 248. 1998. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032499870&partnerID=MN8TOARS . 10.1006/bbrc.1998.8865 . Biochemical and Biophysical Research Communications

Metabolic inhibition increases glutamate susceptibility on a PC12 cell line

Pereira, C; Santos, MS; Oliveira, C; Pereira, C.; Santos, M.S.; Oliveira, C., 1998. Journal of Neuroscience Research. 360 - 370. 3. 51. 1998. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000071805700009&KeyUID=WOS:000071805700009 . 10.1002/(SICI)1097-4547(19980201)51:3<360::AID-JNR9>3.3.CO;2-7 . Journal of Neuroscience Research

Mitochondrial function impairment induced by amyloid beta-peptide on PC12 cells

Pereira, C; Santos, MS; Oliveira, C; Pereira, C.; Santos, M.S.; Oliveira, C., 1998. Neuroreport. 1749 - 1755. 8. 9. 1998. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000074198700015&KeyUID=WOS:000074198700015 . 10.1097/00001756-199806010-00015 . Neuroreport

The protective effect of vitamin E, idebenone and reduced glutathione on free radical mediated injury in rat brain synaptosomes

Cardoso, S.M.; Pereira, C.; Oliveira, C.R., 1998. Biochemical and Biophysical Research Communications. 703 - 710. 3. 246. 1998. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032577242&partnerID=MN8TOARS . 10.1006/bbrc.1998.8563 . Biochemical and Biophysical Research Communications

Interaction between polyalkylcyanoacrylate nanoparticles and peritoneal macrophages: MTT metabolism, NBT reduction, and NO production

Cruz, T.; Gaspar, R.; Donato, A.; Lopes, C., 1997. Pharmaceutical Research. 73 - 79. 1. 14. 1997. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031042535&partnerID=MN8TOARS . 10.1023/A:1012059501947 . Pharmaceutical Research

Glutamate toxicity on a PC12 cell line involves glutathione (GSH) depletion and oxidative stress

Pereira, C.M.F.; Oliveira, C.R., 1997. Free Radical Biology and Medicine. 637 - 647. 4. 23. 1997. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030757990&partnerID=MN8TOARS . 10.1016/S0891-5849(97)00020-8 . Free Radical Biology and Medicine

Contribution of plasma membrane and endoplasmic reticulum Ca2+-ATPases to the synaptosomal [Ca2+]i increase during oxidative stress

Pereira, C.; Ferreira, C.; Carvalho, C.; Oliveira, C., 1996. Brain Research. 269 - 277. 1-2. 713. 1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029928472&partnerID=MN8TOARS . 10.1016/0006-8993(95)01554-X . Brain Research

Effect of lipid peroxidation on [Ca2+]i of rat synaptosomes

Pereira, Cláudia; Resende de Oliveira, Catarina, 1993. Journal of Neurochemistry. S151D - S151D. supplement. 1993. published Journal of Neurochemistry

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