Aging
Hypothalamus
Neuroendocrine peptides
Autophagy
Cellular senescence
Hypothalamic control of Aging
Caloric restriction and related mechanisms as anti-Aging interventions
Neuroendocrine peptides as novel therapeutic interventions to delay aging and age-related disease, including Hutchinson-Gilford Progeria Syndrome, a premature aging disease
Human life expectancy is increasing and so too the socioeconomic burden of age-related diseases. Although the molecular mechanisms underlying aging remain an extremely active area of research, their exact nature remains obscure. Understanding the biological bases of aging is utmost important to future genetic/pharmacological interventions to ameliorate age-related deteriorations and promote a “healthy” and active aging. In recent years hypothalamus has emerged as a key player in whole-body aging. This brain region regulates body homeostasis through specialized neurons that sense and integrate central and peripheral signals to properly coordinate several survival functions, including development, reproduction, circadian rhythms, food intake, metabolism and neuroendocrine axis. Therefore, a decline in hypothalamic neurons responsiveness with age may adversely affect body physiological functions. In line with this, we are focused on better understand the molecular and cellular mechanisms underlying aging and how hypothalamus regulates whole-body aging with the ultimate goal of finding new therapeutic targets to delay the aging process of normal and premature aging diseases and improve “healthy” aging. In our group we use both in vitro and in vivo experimental models and a combination of molecular, cellular, and histological techniques with behavior and bioinformatics analysis to better understand the mechanisms underlying the aging process.
Information about journal articles, updated at 22-05-2022, from platform CIÊNCIAVITAE.
Enhancing ghrelin signaling alleviates aging and extends lifespan of a mouse model of human accelerated aging syndrome (under submission).
Ferreira-Marques, M (EA15-6C9F-F15E); Carvalho, A; Franco, Ana Catarina; Leal, A; Botelho, M; Carmo-Silva, Sara; Águas, R; et al, 2022. 2022. submitted
Ataxin-2 in the hypothalamus at the crossroads between metabolism & circadian rhythm (under revision)
Carmo-Silva, Sara; Ferreira-Marques, M (EA15-6C9F-F15E); Nóbrega, Clévio David Rodrigues ; Botelho M; Costa, D; Aveleira C; Pulst, Stefan; Almeida, Luís Pereira de; Cavadas, Claudia, 2022. Journal of Molecular Endocrinology. 2022. under revision Journal of Molecular Endocrinology
Leptin enhances progerin clearance and ameliorates the senescent phenotype of human Hutchinson-Gilford Progeria Syndrome cells (under submission))
Real, AC; Ferreira-Marques, M (EA15-6C9F-F15E); Cortes, Luisa; Cavadas, Cláudia (D413-2E77-4BDE); Aveleira, Célia A (651B-75AE-BD02), 2022. 2022. submitted
Skin senescence: mechanisms and impact on whole-body aging
Ana Catarina Franco; Aveleira C; Cavadas, Claudia, 2022. Trends Molecular Medicine. 97 - 109. 2. 28. 2022. published Trends Molecular Medicine
Cellular senescence mechanisms in the context of current biomarkers and senotherapies (under submission)
Vasco Lucas; Claudia Cavadas; Aveleira C, 2022. Pharmacological Reviews. 2022. submitted Pharmacological Reviews
PI3K/AKT/MTOR and ERK1/2/MAPK signaling pathways are involved in autophagy stimulation induced by caloric restriction or caloric restriction mimetics in cortical neurons.
Ferreira-Marques, Marisa (EA15-6C9F-F15E); Carvalho, A; Cavadas, Cláudia (D413-2E77-4BDE); Aveleira, Célia A (651B-75AE-BD02), 2021. Aging. 2021. accepted Aging
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
Klionsky D J; Abdel-Aziz A K; ...; Aveleira C; Chun-Kit Tong, 2021. Autophagy. 2021. https://www.tandfonline.com/doi/full/10.1080/15548627.2020.1797280 . published Autophagy
Neuropeptide Y Enhances Progerin Clearance and Ameliorates the Senescent Phenotype of Human Hutchinson-Gilford Progeria Syndrome Cells.
Aveleira, Célia A; Ferreira-Marques, Marisa; Cortes, Luísa; Valero, Jorge; Pereira, Dina; Pereira de Almeida, Luís; Cavadas, Cláudia, 2020. The Journals of Gerontology: Series A. 2020. http://dx.doi.org/10.1093/gerona/glz280 . 10.1093/gerona/glz280 . published The Journals of Gerontology: Series A
Elevated Glucose and Interleukin-1ß Differentially Affect Retinal Microglial Cell Proliferation
Baptista, Filipa I.; Aveleira, Célia A.; Castilho, Áurea F.; Ambrósio, António F., 2017. Mediators of Inflammation. 1 - 11. 2017. 2017. http://dx.doi.org/10.1155/2017/4316316 . 10.1155/2017/4316316 . published Mediators of Inflammation
The pathophysiology of defective proteostasis in the hypothalamus - from obesity to ageing
Cavadas, Cláudia; Aveleira, Célia A.; Souza, Gabriela F. P.; Velloso, Lício A., 2016. Nature Reviews Endocrinology. 723 - 733. 12. 12. 2016. http://dx.doi.org/10.1038/nrendo.2016.107 . 10.1038/nrendo.2016.107 . published Nature Reviews Endocrinology
Caloric restriction stimulates autophagy in rat cortical neurons through neuropeptide Y and ghrelin receptors activation
Ferreira-Marques, Marisa; Aveleira, Célia A.; Carmo-Silva, Sara; Botelho, Mariana; Pereira de Almeida, Luís; Cavadas, Cláudia, 2016. Aging. 1470 - 1484. 7. 8. 2016. http://dx.doi.org/10.18632/aging.100996 . 10.18632/aging.100996 . published Aging
Impaired adrenal medullary function in a mouse model of depression induced by unpredictable chronic stress
Santana, Magda M.; Rosmaninho-Salgado, Joana; Cortez, Vera; Pereira, Frederico C.; Kaster, Manuella P.; Aveleira, Célia A.; Ferreira, Marisa; Álvaro, Ana Rita; Cavadas, Cláudia, 2015. European Neuropsychopharmacology. 1753 - 1766. 10. 25. 2015. http://dx.doi.org/10.1016/j.euroneuro.2015.06.013 . 10.1016/j.euroneuro.2015.06.013 . published European Neuropsychopharmacology
Neuropeptide Y stimulates autophagy in hypothalamic neurons
Aveleira, Célia A.; Botelho, Mariana; Carmo-Silva, Sara; Pascoal, Jorge F.; Ferreira-Marques, Marisa; Nóbrega, Clévio; Cortes, Luísa; et al, 2015. Proceedings of the National Academy of Sciences. E1642 - E1651. 13. 112. 2015. http://dx.doi.org/10.1073/pnas.1416609112 . 10.1073/pnas.1416609112 . published Proceedings of the National Academy of Sciences
NPY/neuropeptide Y enhances autophagy in the hypothalamus: a mechanism to delay aging?
Aveleira, Célia A; Botelho, Mariana; Cavadas, Cláudia, 2015. Autophagy. 1431 - 1433. 8. 11. 2015. http://dx.doi.org/10.1080/15548627.2015.1062202 . 10.1080/15548627.2015.1062202 . Autophagy
Long-term exposure to high glucose increases the content of several exocytotic proteins and of vesicular GABA transporter in cultured retinal neural cells
Baptista, Filipa I.; Castilho, Áurea F.; Gaspar, Joana M.; Liberal, Joana T.; Aveleira, Célia A.; Ambrósio, António F., 2015. Neuroscience Letters. 56 - 61. 602. 2015. http://dx.doi.org/10.1016/j.neulet.2015.06.044 . 10.1016/j.neulet.2015.06.044 . published Neuroscience Letters
Alterations in phospholipidomic profile in the brain of mouse model of depression induced by chronic unpredictable stress
Faria, R.; Santana, M.M.; Aveleira, C.A.; Simões, C.; Maciel, E.; Melo, T.; Santinha, D.; et al, 2014. Neuroscience. 1 - 11. 273. 2014. http://dx.doi.org/10.1016/j.neuroscience.2014.04.042 . 10.1016/j.neuroscience.2014.04.042 . published Neuroscience
Fluoxetine Induces Proliferation and Inhibits Differentiation of Hypothalamic Neuroprogenitor Cells In Vitro
Sousa-Ferreira, Lígia; Aveleira, Célia; Botelho, Mariana; Álvaro, Ana Rita; Pereira de Almeida, Luís; Cavadas, Cláudia, 2014. PLoS ONE. 3. 9. 2014. http://dx.doi.org/10.1371/journal.pone.0088917 . 10.1371/journal.pone.0088917 . published PLoS ONE
Beclin 1 mitigates motor and neuropathological deficits in genetic mouse models of Machado–Joseph disease
Nascimento-Ferreira, Isabel; Nóbrega, Clévio; Vasconcelos-Ferreira, Ana; Onofre, Isabel; Albuquerque, David; Aveleira, Célia; Hirai, Hirokazu; Déglon, Nicole; Pereira de Almeida, Luís, 2013. Brain. 2173 - 2188. 7. 136. 2013. http://dx.doi.org/10.1093/brain/awt144 . 10.1093/brain/awt144 . published Brain
Neuropeptide Y Receptors Y1 and Y2 are Present in Neurons and Glial Cells in Rat Retinal Cells in Culture
Santos-Carvalho, Ana; Aveleira, Célia A.; Elvas, Filipe; Ambrósio, António Francisco; Cavadas, Cláudia, 2013. Investigative Opthalmology & Visual Science. 1. 54. 2013. http://dx.doi.org/10.1167/iovs.12-10776 . 10.1167/iovs.12-10776 . published Investigative Opthalmology & Visual Science
Heme Oxygenase-1 Protects Retinal Endothelial Cells against High Glucose- and Oxidative/Nitrosative Stress-Induced Toxicity
Castilho, Áurea F.; Aveleira, Célia A.; Leal, Ermelindo C.; Simões, Núria F.; Fernandes, Carolina R.; Meirinhos, Rita I.; Baptista, Filipa I.; Ambrósio, António F., 2012. PLoS ONE. 8. 7. 2012. http://dx.doi.org/10.1371/journal.pone.0042428 . 10.1371/journal.pone.0042428 . published PLoS ONE
Proliferative Hypothalamic Neurospheres Express NPY, AGRP, POMC, CART and Orexin-A and Differentiate to Functional Neurons
Sousa-Ferreira, Lígia; Álvaro, Ana Rita; Aveleira, Célia; Santana, Magda; Brandão, Inês; Kügler, Sebastian; Pereira de Almeida, Luís; Cavadas, Cláudia, 2011. PLoS ONE. 5. 6. 2011. http://dx.doi.org/10.1371/journal.pone.0019745 . 10.1371/journal.pone.0019745 . published PLoS ONE
High glucose and interleukin-1ß downregulate interleukin-1 type I receptor (IL-1RI) in retinal endothelial cells by enhancing its degradation by a lysosome-dependent mechanism
Aveleira, Célia; Castilho, Áurea; Baptista, Filipa; Simões, Núria; Fernandes, Carolina; Leal, Ermelindo; Ambrósio, António Francisco, 2010. Cytokine. 279 - 286. 3. 49. 2010. http://dx.doi.org/10.1016/j.cyto.2009.11.014 . 10.1016/j.cyto.2009.11.014 . published Cytokine
TNF- Signals Through PKCz /NF- kB to Alter the Tight Junction Complex and Increase Retinal Endothelial Cell Permeability
Aveleira, C. A.; Lin, C.-M.; Abcouwer, S. F.; Ambrosio, A. F.; Antonetti, D. A., 2010. Diabetes. 2872 - 2882. 11. 59. 2010. http://dx.doi.org/10.2337/db09-1606 . 10.2337/db09-1606 . published Diabetes
High glucose and oxidative/nitrosative stress conditions induce apoptosis in retinal endothelial cells by a caspase-independent pathway
Leal, Ermelindo C.; Aveleira, Célia A.; Castilho, Áurea F.; Serra, Andreia M.; Baptista, Filipa I.; Hosoya, Ken-Ichi; Forrester, John V.; Ambrósio, António F., 2009. Experimental Eye Research. 983 - 991. 5. 88. 2009. http://dx.doi.org/10.1016/j.exer.2008.12.010 . 10.1016/j.exer.2008.12.010 . published Experimental Eye Research
Müller Cells Do Not Influence Leukocyte Adhesion to Retinal Endothelial Cells
Leal, Ermelindo C.; Aveleira, Célia A.; Castilho, Aurea F.; Baptista, Filipa I.; Ambrósio, António F., 2008. Ocular Immunology and Inflammation. 173 - 179. 4. 16. 2008. http://dx.doi.org/10.1080/09273940802204535 . 10.1080/09273940802204535 . published Ocular Immunology and Inflammation
NPY in rat retina is present in neurons, in endothelial cells and also in microglial and Müller cells
Álvaro, Ana Rita; Rosmaninho-Salgado, Joana; Santiago, Ana Raquel; Martins, João; Aveleira, Célia; Santos, Paulo F.; Pereira, Tiago; et al, 2007. Neurochemistry International. 757 - 763. 5. 50. 2007. http://dx.doi.org/10.1016/j.neuint.2007.01.010 . 10.1016/j.neuint.2007.01.010 . published Neurochemistry International
5 26 out of 26 Publications
Janssen Inovação Award (2nd place)
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