Neuroscience and Disease

Synapse Biology

Excitatory Synapses

Neuronal Excitability

Synaptic Plasticy

Synaptic Dysfunction

Neuropsychiatric Disorders

Overview

Memories, thoughts and behavior are encoded in changes in the strength of synaptic communication. These changes constitute the cellular and molecular basis of information processing underlying brain function. However, the functional transformations used by synapses to encode and process information are still poorly understood. We are interested in the cellular and molecular mechanisms of synaptic function and plasticity, and in how synaptic dysfunction underlies neuropsychiatric and neurodegenerative disorders.

We use a combination of techniques like primary cultures of dissociated neurons and brain slices, biochemistry, molecular and cellular biology, mouse molecular genetics, electrophysiology and behavior analysis to address the role of molecular players and of neuromodulatory processes that regulate neurotransmitter receptors and synaptic function and plasticity.

This fundamental research has strong implications to cognitive disorders, since genetic variants in multiple synaptic proteins are linked to intellectual disability, schizophrenia and autism spectrum disorders, and age-associated neurodegenerative disorders are at their initial stages originated by defects in synaptic transmission. We focus on disease-related alterations in synaptic function, either genetic, triggered by experience or by antibodies produced by autoimmune synaptic encephalitis patients, to understand how synaptic dysfunction underlies disease pathogenesis. Our cellular and molecular studies and the animal models that we are generating can also contribute to the rational development of therapies for these diseases.

Featured Articles

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Information about journal articles, updated at 21-11-2021, from platform CIÊNCIAVITAE.

MicroRNA-186-5p controls GluA2 surface expression and synaptic scaling in hippocampal neurons

Mariline M. Silva; Beatriz Rodrigues; Joana Fernandes; Sandra D. Santos; Laura Carreto; Manuel A. S. Santos; Paulo Pinheiro; et al, 2019. Proceedings of the National Academy of Sciences. 5727 - 5736. 12. 116. 2019. https://doi.org/10.1073/pnas.1900338116 . 10.1073/pnas.1900338116 . published Proceedings of the National Academy of Sciences

Disrupted AMPA Receptor Function upon Genetic- or Antibody-Mediated Loss of Autism-Associated CASPR2

Dominique Fernandes; Sandra D Santos; Ester Coutinho; Jessica L Whitt; Nuno Beltrão; Tiago Rondão; M Isabel Leite; et al, 2019. Cerebral Cortex. 2019. https://doi.org/10.1093/cercor/bhz032 . 10.1093/cercor/bhz032 . Cerebral Cortex

Ataxin-3 phosphorylation decreases neuronal defects in spinocerebellar ataxia type 3 models

Matos, C.A.; Nóbrega, C.; Louros, S.R.; Almeida, B.; Ferreiro, E.; Valero, J.; De Almeida, L.P.; Macedo-Ribeiro, S.; Carvalho, A.L., 2016. Journal of Cell Biology. 465 - 480. 4. 212. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84959536774&partnerID=MN8TOARS . 10.1083/jcb.201506025 . Journal of Cell Biology

Ghrelin triggers the synaptic incorporation of AMPA receptors in the hippocampus

Ribeiro, L.F.; Catarino, T.; Santos, S.D.; Benoist, M.; Van Leeuwen, J.F.; Esteban, J.A.; Carvalho, A.L., 2014. Proceedings of the National Academy of Sciences of the United States of America. 1. 111. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84891958005&partnerID=MN8TOARS . 10.1073/pnas.1313798111 . Proceedings of the National Academy of Sciences of the United States of America

New insights on synaptic dysfunction in neuropsychiatric disorders

Lima Caldeira, G.; Peça, J.; Carvalho, A.L., 2019. Current Opinion in Neurobiology. 62 - 70. 57. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85061115086&partnerID=MN8TOARS . 10.1016/j.conb.2019.01.004 . Current Opinion in Neurobiology


Publications

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Information about journal articles, updated at 21-11-2021, from platform CIÊNCIAVITAE.

Ligand-independent activity of the ghrelin receptor modulates AMPA receptor trafficking and supports memory formation

Ribeiro, Luís F.; Catarino, Tatiana; Carvalho, Mário; Cortes, Luísa; Santos, Sandra D.; Opazo, Patricio O.; Ribeiro, Lyn Rosenbrier; et al, 2021. Science Signaling. 670. 14. 2021. http://dx.doi.org/10.1126/scisignal.abb1953 . 10.1126/scisignal.abb1953 . Science Signaling

Abnormal mGluR-mediated synaptic plasticity and autism-like behaviours in Gprasp2 mutant mice

Edfawy, Mohamed; Guedes, Joana R.; Pereira, Marta I.; Laranjo, Mariana; Carvalho, Mário J.; Gao, Xian; Ferreira, Pedro A.; et al, 2019. Nature Communications. 1. 10. 2019. http://dx.doi.org/10.1038/s41467-019-09382-9 . 10.1038/s41467-019-09382-9 . Nature Communications

Disrupted AMPA Receptor Function upon Genetic- or Antibody-Mediated Loss of Autism-Associated CASPR2

Dominique Fernandes; Sandra D Santos; Ester Coutinho; Jessica L Whitt; Nuno Beltrão; Tiago Rondão; M Isabel Leite; et al, 2019. Cerebral Cortex. 2019. https://doi.org/10.1093/cercor/bhz032 . 10.1093/cercor/bhz032 . Cerebral Cortex

The role of ghrelin in regulating synaptic function and plasticity of feeding-associated circuits

Serrenho, D.; Santos, S.D.; Carvalho, A.L., 2019. Frontiers in Cellular Neuroscience. 13. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85068476880&partnerID=MN8TOARS . 10.3389/fncel.2019.00205 . Frontiers in Cellular Neuroscience

New insights on synaptic dysfunction in neuropsychiatric disorders

Lima Caldeira, G.; Peça, J.; Carvalho, A.L., 2019. Current Opinion in Neurobiology. 62 - 70. 57. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85061115086&partnerID=MN8TOARS . 10.1016/j.conb.2019.01.004 . Current Opinion in Neurobiology

MicroRNA-186-5p controls GluA2 surface expression and synaptic scaling in hippocampal neurons

Mariline M. Silva; Beatriz Rodrigues; Joana Fernandes; Sandra D. Santos; Laura Carreto; Manuel A. S. Santos; Paulo Pinheiro; et al, 2019. Proceedings of the National Academy of Sciences. 5727 - 5736. 12. 116. 2019. https://doi.org/10.1073/pnas.1900338116 . 10.1073/pnas.1900338116 . published Proceedings of the National Academy of Sciences

Differential Nanoscale Topography and Functional Role of GluN2-NMDA Receptor Subtypes at Glutamatergic Synapses

Kellermayer, B.; Ferreira, J.S.; Dupuis, J.; Levet, F.; Grillo-Bosch, D.; Bard, L.; Linarès-Loyez, J.; et al, 2018. Neuron. 106 - 119.e7. 1. 100. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85054706658&partnerID=MN8TOARS . 10.1016/j.neuron.2018.09.012 . Neuron

Metabotropic glutamate type 5 receptor requires contactin-associated protein 1 to control memory formation

Morató, X.; Luján, R.; Gonçalves, N.; Watanabe, M.; Altafaj, X.; Carvalho, A.L.; Fernández-Dueñas, V.; Cunha, R.A.; Ciruela, F., 2018. Human Molecular Genetics. 3528 - 3541. 20. 27. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85054354803&partnerID=MN8TOARS . 10.1093/hmg/ddy264 . Human Molecular Genetics

Stargazin Dephosphorylation Mediates Homeostatic Synaptic Downscaling of Excitatory Synapses

Louros, S.R.; Caldeira, G.L.; Carvalho, A.L., 2018. Frontiers in Molecular Neuroscience. 11. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85054810796&partnerID=MN8TOARS . 10.3389/fnmol.2018.00328 . Frontiers in Molecular Neuroscience

Multiple domains in the C-terminus of NMDA receptor GluN2B subunit contribute to neuronal death following in vitro ischemia

Vieira, M.M.; Schmidt, J.; Ferreira, J.S.; She, K.; Oku, S.; Mele, M.; Santos, A.E.; et al, 2016. Neurobiology of Disease. 223 - 234. 89. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84959360132&partnerID=MN8TOARS . 10.1016/j.nbd.2015.11.007 . Neurobiology of Disease

Ataxin-3 phosphorylation decreases neuronal defects in spinocerebellar ataxia type 3 models

Matos, C.A.; Nóbrega, C.; Louros, S.R.; Almeida, B.; Ferreiro, E.; Valero, J.; De Almeida, L.P.; Macedo-Ribeiro, S.; Carvalho, A.L., 2016. Journal of Cell Biology. 465 - 480. 4. 212. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84959536774&partnerID=MN8TOARS . 10.1083/jcb.201506025 . Journal of Cell Biology

7th ISN special neurochemistry conference ‘Synaptic function and dysfunction in brain diseases’

Carlos B. Duarte; Ana Luisa Carvalho, 2016. Journal of Neurochemistry. 2016. http://dx.doi.org/10.1111/jnc.13839 . 10.1111/jnc.13839 . Journal of Neurochemistry

Mechanisms of homeostatic plasticity in the excitatory synapse

Dominique Fernandes; Ana Luísa Carvalho, 2016. Journal of Neurochemistry. 2016. http://dx.doi.org/10.1111/jnc.13687 . 10.1111/jnc.13687 . Journal of Neurochemistry

Biotinylation and Purification of Plasma Membrane-associated Proteins from Rodent Cultured Neurons

Caldeira, Margarida; Ferreira, Joana; Carvalho, Ana; Duarte, Carlos, 2016. BIO-PROTOCOL. 10. 6. 2016. http://dx.doi.org/10.21769/bioprotoc.1807 . 10.21769/bioprotoc.1807 . BIO-PROTOCOL

GluN2B-containing NMDA receptors regulate AMPA receptor traffic through anchoring of the synaptic proteasome

Ferreira, J.S.; Schmidt, J.; Rio, P.; Águas, R.; Rooyakkers, A.; Li, K.W.; Smit, A.B.; Craig, A.M.; Carvalho, A.L., 2015. Journal of Neuroscience. 8462 - 8479. 22. 35. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930427217&partnerID=MN8TOARS . 10.1523/JNEUROSCI.3567-14.2015 . Journal of Neuroscience

SUMOylation of the brain-predominant Ataxin-3 isoform modulates its interaction with p97

Almeida, B.; Abreu, I.A.; Matos, C.A.; Fraga, J.S.; Fernandes, S.; Macedo, M.G.; Gutiérrez-Gallego, R.; et al, 2015. Biochimica et Biophysica Acta - Molecular Basis of Disease. 1950 - 1959. 9. 1852. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84955513053&partnerID=MN8TOARS . 10.1016/j.bbadis.2015.06.010 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Aß and NMDAR activation cause mitochondrial dysfunction involving ER calcium release

Ferreira, I.L.; Ferreiro, E.; Schmidt, J.; Cardoso, J.M.; Pereira, C.M.F.; Carvalho, A.L.; Oliveira, C.R.; Rego, A.C., 2015. Neurobiology of Aging. 680 - 692. 2. 36. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84922927392&partnerID=MN8TOARS . 10.1016/j.neurobiolaging.2014.09.006 . Neurobiology of Aging

Impaired Src signaling and post-synaptic actin polymerization in Alzheimer's disease mice hippocampus - Linking NMDA receptors and the reelin pathway

Mota, S.I.; Ferreira, I.L.; Valero, J.; Ferreiro, E.; Carvalho, A.L.; Oliveira, C.R.; Rego, A.C., 2014. Experimental Neurology. 698 - 709. 261. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84908339906&partnerID=MN8TOARS . 10.1016/j.expneurol.2014.07.023 . Experimental Neurology

Ghrelin triggers the synaptic incorporation of AMPA receptors in the hippocampus

Ribeiro, L.F.; Catarino, T.; Santos, S.D.; Benoist, M.; Van Leeuwen, J.F.; Esteban, J.A.; Carvalho, A.L., 2014. Proceedings of the National Academy of Sciences of the United States of America. 1. 111. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84891958005&partnerID=MN8TOARS . 10.1073/pnas.1313798111 . Proceedings of the National Academy of Sciences of the United States of America

Ischemic insults induce necroptotic cell death in hippocampal neurons through the up-regulation of endogenous RIP3

Vieira, M.; Fernandes, J.; Carreto, L.; Anuncibay-Soto, B.; Santos, M.; Han, J.; Fernández-López, A.; et al, 2014. Neurobiology of Disease. 26 - 36. 68. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84899850247&partnerID=MN8TOARS . 10.1016/j.nbd.2014.04.002 . Neurobiology of Disease

In vitro ischemia triggers a transcriptional response to down-regulate synaptic proteins in hippocampal neurons

Fernandes, J.; Vieira, M.; Carreto, L.; Santos, M.A.S.; Duarte, C.B.; Carvalho, A.L.; Santos, A.E., 2014. PLoS ONE. 6. 9. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903512303&partnerID=MN8TOARS . 10.1371/journal.pone.0099958 . PLoS ONE

Diabetes causes transient changes in the composition and phosphorylation of a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors and interaction with auxiliary proteins in the rat retina

Castilho, A.F.; Liberal, J.T.; Baptista, F.I.; Gaspar, J.M.; Carvalho, A.L.; Ambrósio, A.F., 2014. Molecular Vision. 894 - 907. 20. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903118075&partnerID=MN8TOARS . Molecular Vision

A role for stargazin in experience-dependent plasticity

Louros, S.; Hooks, B.; Litvina, L.; Carvalho, A.; Chen, C., 2014. Cell Reports. 1614 - 1625. 5. 7. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84902344846&partnerID=MN8TOARS . 10.1016/j.celrep.2014.04.054 . Cell Reports

Regulation of synapse composition by protein acetylation: The role of acetylated cortactin

Catarino, T.; Ribeiro, L.; Santos, S.D.; Carvalho, A.L., 2013. Journal of Cell Science. 149 - 162. 1. 126. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875621271&partnerID=MN8TOARS . 10.1242/jcs.110742 . Journal of Cell Science

Contactin-associated protein 1 (Caspr1) regulates the traffic and synaptic content of a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors

Santos, S.D.; Iuliano, O.; Ribeiro, L.; Veran, J.; Ferreira, J.S.; Rio, P.; Mulle, C.; Duarte, C.B.; Carvalho, A.L., 2012. Journal of Biological Chemistry. 6868 - 6877. 9. 287. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857468361&partnerID=MN8TOARS . 10.1074/jbc.M111.322909 . Journal of Biological Chemistry

Elevated glucose concentration changes the content and cellular localization of AMPA receptors in the retina but not in the hippocampus

Castilho, A.F.; Liberal, J.T.; Baptista, F.I.; Gaspar, J.M.; Carvalho, A.L.; Ambrósio, A.F., 2012. Neuroscience. 23 - 32. 219. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864022057&partnerID=MN8TOARS . 10.1016/j.neuroscience.2012.05.056 . Neuroscience

Glutamate Binding to the GluN2B Subunit Controls Surface Trafficking of N-Methyl-D-aspartate (NMDA) Receptors

She, Kevin; Ferreira, Joana S.; Carvalho, Ana Luisa; Craig, Ann Marie, 2012. Journal of Biological Chemistry. 27432 - 27445. 33. 287. 2012. 10.1074/jbc.M112.345108 . Journal of Biological Chemistry

Cleavage of the vesicular glutamate transporters under excitotoxic conditions

Lobo, A.C.; Gomes, J.R.; Catarino, T.; Mele, M.; Fernandez, P.; Inácio, A.R.; Bahr, B.A.; et al, 2011. Neurobiology of Disease. 292 - 303. 3. 44. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80053269066&partnerID=MN8TOARS . 10.1016/j.nbd.2011.07.010 . Neurobiology of Disease

Polyglutamine diseases: The special case of ataxin-3 and Machado-Joseph disease

Matos, C.A.; de Macedo-Ribeiro, S.; Carvalho, A.L., 2011. Progress in Neurobiology. 26 - 48. 1. 95. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960668226&partnerID=MN8TOARS . 10.1016/j.pneurobio.2011.06.007 . Progress in Neurobiology

Activity and protein kinase C regulate synaptic accumulation of N-Methyl-D-aspartate (NMDA) receptors independently of GluN1 splice variant

Ferreira, J.S.; Rooyakkers, A.; She, K.; Ribeiro, L.; Carvalho, A.L.; Craig, A.M., 2011. Journal of Biological Chemistry. 28331 - 28342. 32. 286. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80051515440&partnerID=MN8TOARS . 10.1074/jbc.M111.222539 . Journal of Biological Chemistry

Proteomic analysis of an interactome for long-form AMPA receptor subunits

Santos, S.D.; Manadas, B.; Duarte, C.B.; Carvalho, A.L., 2010. Journal of Proteome Research. 1670 - 1682. 4. 9. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77950666645&partnerID=MN8TOARS . 10.1021/pr900766r . Journal of Proteome Research

Excitotoxicity through Ca2+-permeable AMPA receptors requires Ca2+-dependent JNK activation

Vieira, M.; Fernandes, J.; Burgeiro, A.; Thomas, G.M.; Huganir, R.L.; Duarte, C.B.; Carvalho, A.L.; Santos, A.E., 2010. Neurobiology of Disease. 645 - 655. 3. 40. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957795389&partnerID=MN8TOARS . 10.1016/j.nbd.2010.08.008 . Neurobiology of Disease

Leptin regulates AMPA receptor trafficking via PTEN inhibition

Moult, P.R.; Cross, A.; Santos, S.D.; Carvalho, A.-L.; Lindsay, Y.; Connolly, C.N.; Irving, A.J.; Leslie, N.R.; Harvey, J., 2010. Journal of Neuroscience. 4088 - 4101. 11. 30. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77949725839&partnerID=MN8TOARS . 10.1523/JNEUROSCI.3614-09.2010 . Journal of Neuroscience

Nucleocytoplasmic shuttling activity of ataxin-3

Macedo-Ribeiro, S.; Cortes, L.; Maciel, P.; Carvalho, A.L., 2009. PLoS ONE. 6. 4. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-67149129949&partnerID=MN8TOARS . 10.1371/journal.pone.0005834 . PLoS ONE

Regulation of AMPA receptors and synaptic plasticity

Santos, S.D.; Carvalho, A.L.; Caldeira, M.V.; Duarte, C.B., 2009. Neuroscience. 105 - 125. 1. 158. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-58149467917&partnerID=MN8TOARS . 10.1016/j.neuroscience.2008.02.037 . Neuroscience

African swine fever virus p10 protein exhibits nuclear import capacity and accumulates in the nucleus during viral infection

Nunes-Correia, I.; Rodríguez, J.M.; Eulálio, A.; Carvalho, A.L.; Citovsky, V.; Simões, S.; Faro, C.; Salas, M.L.; Pedroso de Lima, M.C., 2008. Veterinary Microbiology. 47 - 59. 1-2. 130. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-46549086170&partnerID=MN8TOARS . 10.1016/j.vetmic.2007.12.010 . Veterinary Microbiology

Striatal and nigral pathology in a lentiviral rat model of Machado-Joseph disease

Alves, S.; Régulier, E.; Nascimento-Ferreira, I.; Hassig, R.; Dufour, N.; Koeppen, A.; Carvalho, A.L.; et al, 2008. Human Molecular Genetics. 2071 - 2083. 14. 17. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-46249122383&partnerID=MN8TOARS . 10.1093/hmg/ddn106 . Human Molecular Genetics

Characterization of alternatively spliced isoforms of AMPA receptor subunits encoding truncated receptors

Gomes, A.R.; Ferreira, J.S.; Paternain, A.V.; Lerma, J.; Duarte, C.B.; Carvalho, A.L., 2008. Molecular and Cellular Neuroscience. 323 - 334. 2. 37. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-38749131588&partnerID=MN8TOARS . 10.1016/j.mcn.2007.10.008 . Molecular and Cellular Neuroscience

Role of the brain-derived neurotrophic factor at glutamatergic synapses

Carvalho, A.L.; Caldeira, M.V.; Santos, S.D.; Duarte, C.B., 2008. British Journal of Pharmacology. SUPPL. 1. 153. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-40349114504&partnerID=MN8TOARS . 10.1038/sj.bjp.0707509 . British Journal of Pharmacology

PKC anchoring to GluR4 AMPA receptor subunit modulates PKC-driven receptor phosphorylation and surface expression

Gomes, A.R.; Correia, S.S.; Esteban, J.A.; Duarte, C.B.; Carvalho, A.L., 2007. Traffic. 259 - 269. 3. 8. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34247490214&partnerID=MN8TOARS . 10.1111/j.1600-0854.2006.00521.x . Traffic

Erratum: Brain-derived neurotrophic factor regulates the expression and synaptic delivery of a-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunits in hippocampal neurons (Journal of Biological Chemistry (2007) 282, (12619-12628))

Caldeira, M.V.; Melo, C.V.; Pereira, D.B.; Carvalho, R.; Correia, S.S.; Backos, D.S.; Carvalho, A.L.; Esteban, J.A.; Duarte, C.B., 2007. Journal of Biological Chemistry. 37. 282. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34848900818&partnerID=MN8TOARS . Journal of Biological Chemistry

BDNF regulates the expression and traffic of NMDA receptors in cultured hippocampal neurons

Caldeira, M.V.; Melo, C.V.; Pereira, D.B.; Carvalho, R.F.; Carvalho, A.L.; Duarte, C.B., 2007. Molecular and Cellular Neuroscience. 208 - 219. 2. 35. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34249712975&partnerID=MN8TOARS . 10.1016/j.mcn.2007.02.019 . Molecular and Cellular Neuroscience

NPY in rat retina is present in neurons, in endothelial cells and also in microglial and Müller cells

Álvaro, A.R.; Rosmaninho-Salgado, J.; Santiago, A.R.; Martins, J.; Aveleira, C.; Santos, P.F.; Pereira, T.; et al, 2007. Neurochemistry International. 757 - 763. 5. 50. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947389655&partnerID=MN8TOARS . 10.1016/j.neuint.2007.01.010 . Neurochemistry International

Brain-derived neurotrophic factor regulates the expression and synaptic delivery of a-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunits in hippocampal neurons

Caldeira, M.V.; Melo, C.V.; Pereira, D.B.; Carvalho, R.; Correia, S.S.; Backos, D.S.; Carvalho, A.L.; Esteban, J.A.; Duarte, C.B., 2007. Journal of Biological Chemistry. 12619 - 12628. 17. 282. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34250329980&partnerID=MN8TOARS . 10.1074/jbc.M700607200 . Journal of Biological Chemistry

NEDD8: A new ataxin-3 interactor

Ferro, A.; Carvalho, A.L.; Teixeira-Castro, A.; Almeida, C.; Tomé, R.J.; Cortes, L.; Rodrigues, A.-J.; et al, 2007. Biochimica et Biophysica Acta - Molecular Cell Research. 1619 - 1627. 11. 1773. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-35548938484&partnerID=MN8TOARS . 10.1016/j.bbamcr.2007.07.012 . Biochimica et Biophysica Acta - Molecular Cell Research

Excitotoxicity mediated by Ca2+-permeable GluR4-containing AMPA receptors involves the AP-1 transcription factor

Santos, A.E.; Duarte, C.B.; Iizuka, M.; Barsoumian, E.L.; Ham, J.; Lopes, M.C.; Carvalho, A.P.; Carvalho, A.L., 2006. Cell Death and Differentiation. 652 - 660. 4. 13. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644935364&partnerID=MN8TOARS . 10.1038/sj.cdd.4401785 . Cell Death and Differentiation

Purification of a novel aminopeptidase from the pollen of Parietaria judaica that alters epithelial integrity and degrades neuropeptides

Cortes, L.; Carvalho, A.L.; Todo-Bom, A.; Faro, C.; Pires, E.; Veríssimo, P., 2006. Journal of Allergy and Clinical Immunology. 878 - 884. 4. 118. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33749349447&partnerID=MN8TOARS . 10.1016/j.jaci.2006.05.029 . Journal of Allergy and Clinical Immunology

Nuclear export of African swine fever virus p37 protein occurs through two distinct pathways and is mediated by three independent signals

Eulálio, A.; Nunes-Correia, I.; Carvalho, A.L.; Faro, C.; Citovsky, V.; Salas, J.; Salas, M.L.; Simões, S.; Pedroso De Lima, M.C., 2006. Journal of Virology. 1393 - 1404. 3. 80. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-31144441675&partnerID=MN8TOARS . 10.1128/JVI.80.3.1393-1404.2006 . Journal of Virology

Metabotropic glutamate and dopamine receptors co-regulate AMPA receptor activity through PKA in cultured chick retinal neurones: Effect on GluR4 phosphorylation and surface expression

Gomes, A.R.; Cunha, P.; Nuriya, M.; Faro, C.J.; Huganir, R.L.; Pires, E.V.; Carvalho, A.L.; Duarte, C.B., 2004. Journal of Neurochemistry. 673 - 682. 3. 90. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-3342901599&partnerID=MN8TOARS . 10.1111/j.1471-4159.2004.02519.x . Journal of Neurochemistry

Downregulation of retinal GLUT1 in diabetes by ubiquitinylation

Fernandes, R.; Carvalho, A.L.; Kumagai, A.; Seica, R.; Hosoya, K.-I.; Terasaki, T.; Murta, J.; Pereira, P.; Faro, C., 2004. Molecular Vision. 618 - 628. 10. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-16544391719&partnerID=MN8TOARS . Molecular Vision

Two African swine fever virus proteins derived from a common precursor exhibit different nucleocytoplasmic transport activities

Eulálio, A.; Nunes-Correia, I.; Carvalho, A.L.; Faro, C.; Citovsky, V.; Simões, S.; De Lima, M.C.P., 2004. Journal of Virology. 9731 - 9739. 18. 78. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-4444281591&partnerID=MN8TOARS . 10.1128/JVI.78.18.9731-9739.2004 . Journal of Virology

Protein kinase C¿ associates directly with the GluR4 a-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subunit: Effect on receptor phosphorylation

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Regulation of AMPA receptor activity, synaptic targeting and recycling: Role in synaptic plasticity

Gomes, A.R.; Correia, S.S.; Carvalho, A.L.; Duarte, C.B., 2003. Neurochemical Research. 1459 - 1473. 10. 28. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0141705374&partnerID=MN8TOARS . 10.1023/A:1025610122776 . Neurochemical Research

Phosphorylation of GluR4 AMPA-type glutamate receptor subunit by protein kinase C in cultured retina amacrine neurons

Carvalho, A.L.; Correia, S.; Faro, C.J.; Duarte, C.B.; Carvalho, A.P.; Pires, E.M.V., 2002. European Journal of Neuroscience. 465 - 474. 3. 15. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036456320&partnerID=MN8TOARS . 10.1046/j.0953-816x.2001.01881.x . European Journal of Neuroscience

Differential postreceptor signaling events triggered by excitotoxic stimulation of different ionotropic glutamate receptors in retinal Neurons

Santos, A.E.; Carvalho, A.L.; Lopes, M.C.; Carvalho, A.P., 2001. Journal of Neuroscience Research. 643 - 655. 4. 66. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035889524&partnerID=MN8TOARS . 10.1002/jnr.10036 . Journal of Neuroscience Research

Regulation of AMPA Receptors by Phosphorylation

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Characterization of phosphorylation sites on the glutamate receptor 4 subunit of the AMPA receptors

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Calcium influx through AMPA receptors and through calcium channels is regulated by protein kinase C in cultured retina amacrine-like cells

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Glutamate in life and death of retinal amacrine cells

Duarte, C.B.; Ferreira, I.L.; Santos, P.F.; Carvalho, A.L.; Agostinho, P.M.; Carvalho, A.P., 1998. General Pharmacology. 289 - 295. 3. 30. 1998. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032033584&partnerID=MN8TOARS . 10.1016/S0306-3623(97)00360-1 . General Pharmacology

Photoacoustic measurements of porphyrin triplet-state quantum yields and singlet-oxygen efficiencies

Pineiro, M.; Carvalho, A.L.; Pereira, M.M.; Rocha Gonsalves, A.M.D'A.; Arnaut, L.G.; Formosinho, S.J.; Pineiro, M; et al, 1998. Chemistry - A European Journal. 2299 - 2307. 11. 4. 1998. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031742441&partnerID=MN8TOARS . 10.1002/(SICI)1521-3765(19981102)4:11<2299::AID-CHEM2299>3.0.CO;2-H . Chemistry - A European Journal

Differential acetylcholine and GABA release from cultured chick retina cells

Santos, P.F.; Carvalho, A.L.; Carvalho, A.P.; Duarte, C.B., 1998. European Journal of Neuroscience. 2723 - 2730. 8. 10. 1998. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031927252&partnerID=MN8TOARS . 10.1046/j.1460-9568.1998.00281.x . European Journal of Neuroscience

In vivo and in vitro experiments show that betaxolol is a retinal neuroprotective agent

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