Aim

In today’s environment, diverse and often opposing environmental factors coexist; some promoting human health, others predisposing individuals to a wide range of diseases. Physiological decline results from the dynamic interplay between intrinsic metabolic dysfunction (e.g., energy failure, oxidative stress, impaired repair mechanisms) and extrinsic environmental stressors (e.g., diet, toxins, physical inactivity, circadian disruption). In turn, these environmental exposures that an individual experiences throughout their lifetime, the exposome, can be reshaped by climate changes that act as environmental macro-stressors. Together, these processes establish a feed-forward loop that progressively undermines resilience and accelerates both aging and the onset/ development of multiple diseases, such as cancer, diabetes, obesity, as well as cardiovascular, pulmonary, skin and neurodegenerative diseases. This advanced course is conceived as a forum where an interdisciplinary group of experts will present and critically discuss the latest advances in the field. By integrating molecular, physiological, and clinical perspectives, the course will provide participants with state-of-the-art knowledge and comprehensive frameworks for understanding the multifactorial determinants of health and disease. Ultimately, by fostering interdisciplinary dialogue and critical reflection across disciplines, the course seeks to strengthen participants’ scientific capacity, refine their ability to evaluate emerging evidence, and inspire the development of innovative research directions with biomedical relevance.